ZNF707

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.74550884
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.74550884
3sulfur amino acid catabolic process (GO:0000098)6.65198091
4homocysteine metabolic process (GO:0050667)6.41598872
5regulation of plasminogen activation (GO:0010755)5.80117227
6adenosine metabolic process (GO:0046085)5.57170556
7folic acid-containing compound biosynthetic process (GO:0009396)5.53252645
8cysteine metabolic process (GO:0006534)5.48058945
9microtubule nucleation (GO:0007020)5.35369515
10regulation of vitamin D biosynthetic process (GO:0060556)5.23536130
11purine nucleotide salvage (GO:0032261)5.00334220
12white fat cell differentiation (GO:0050872)4.82614271
13phosphatidylglycerol biosynthetic process (GO:0006655)4.73626477
14desmosome organization (GO:0002934)4.30320087
15epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.21686361
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.07870682
17negative regulation of DNA biosynthetic process (GO:2000279)4.06638361
18tRNA modification (GO:0006400)4.04202726
19rRNA methylation (GO:0031167)3.94865247
20mitochondrial RNA metabolic process (GO:0000959)3.93983974
21negative regulation of interleukin-1 beta production (GO:0032691)3.93440396
22positive regulation of gamma-delta T cell activation (GO:0046645)3.89769984
23regulation of vitamin metabolic process (GO:0030656)3.84989131
24behavioral response to nicotine (GO:0035095)3.83896828
25negative regulation of Ras GTPase activity (GO:0034261)3.82661015
26positive regulation of endothelial cell differentiation (GO:0045603)3.79630681
27primary amino compound metabolic process (GO:1901160)3.68047448
28rRNA modification (GO:0000154)3.60009288
29galactose metabolic process (GO:0006012)3.57252199
30negative regulation of interleukin-1 production (GO:0032692)3.54996407
31galactose catabolic process (GO:0019388)3.53658509
32alternative mRNA splicing, via spliceosome (GO:0000380)3.49907231
33adaptation of signaling pathway (GO:0023058)3.47627976
34positive regulation of defense response to virus by host (GO:0002230)3.46850196
35pseudouridine synthesis (GO:0001522)3.39645320
36organic cation transport (GO:0015695)3.36191687
37regulation of gamma-delta T cell activation (GO:0046643)3.27681475
38pteridine-containing compound biosynthetic process (GO:0042559)3.26591481
39regulation of gonadotropin secretion (GO:0032276)3.22506985
40positive regulation of B cell differentiation (GO:0045579)3.19260544
41nucleotide salvage (GO:0043173)3.15763511
42DNA deamination (GO:0045006)3.15133433
43regulation of gamma-delta T cell differentiation (GO:0045586)3.12674269
44negative regulation of cell killing (GO:0031342)3.09714395
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09714395
46regulation of endothelial cell differentiation (GO:0045601)3.09636339
47inner ear receptor cell development (GO:0060119)3.03089442
48protein-chromophore linkage (GO:0018298)3.01333417
49negative regulation of catenin import into nucleus (GO:0035414)2.97945139
50negative regulation of telomerase activity (GO:0051974)2.96898037
51histone H4-K12 acetylation (GO:0043983)2.96346364
52protein-cofactor linkage (GO:0018065)2.95860173
53tolerance induction (GO:0002507)2.95793968
54tryptophan catabolic process (GO:0006569)2.92553967
55indole-containing compound catabolic process (GO:0042436)2.92553967
56indolalkylamine catabolic process (GO:0046218)2.92553967
57cytidine metabolic process (GO:0046087)2.90798464
58cytidine catabolic process (GO:0006216)2.90798464
59cytidine deamination (GO:0009972)2.90798464
60hepatocyte apoptotic process (GO:0097284)2.90643261
61negative regulation of keratinocyte proliferation (GO:0010839)2.90010940
62regulation of sequestering of triglyceride (GO:0010889)2.88311586
63G-protein coupled receptor internalization (GO:0002031)2.88224951
64interferon-gamma production (GO:0032609)2.87909355
65regulation of T cell mediated cytotoxicity (GO:0001914)2.87592616
66positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84245051
67folic acid transport (GO:0015884)2.84243033
68regulation of defense response to virus by host (GO:0050691)2.82614925
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82152204
70tRNA processing (GO:0008033)2.81582576
71folic acid-containing compound metabolic process (GO:0006760)2.80840247
72polyamine biosynthetic process (GO:0006596)2.80653800
73cell migration involved in heart development (GO:0060973)2.74970426
74regulation of tight junction assembly (GO:2000810)2.73168829
75purine-containing compound salvage (GO:0043101)2.72699955
76platelet dense granule organization (GO:0060155)2.72556287
77interferon-gamma secretion (GO:0072643)2.71206059
78negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69230565
79kynurenine metabolic process (GO:0070189)2.68832352
80RNA modification (GO:0009451)2.67722700
81positive regulation of fatty acid oxidation (GO:0046321)2.65986078
82multicellular organism reproduction (GO:0032504)2.65755949
83nucleoside transmembrane transport (GO:1901642)2.61270910
84regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.60855907
85negative regulation of innate immune response (GO:0045824)2.60649924
86negative regulation of cell size (GO:0045792)2.58316415
87folic acid metabolic process (GO:0046655)2.58013837
88preassembly of GPI anchor in ER membrane (GO:0016254)2.56604510
89chemokine-mediated signaling pathway (GO:0070098)2.56596032
90acrosome assembly (GO:0001675)2.55689372
91regulation of antigen processing and presentation (GO:0002577)2.55125258
92tetrahydrofolate metabolic process (GO:0046653)2.54877900
93DNA methylation involved in gamete generation (GO:0043046)2.54627890
94tryptophan metabolic process (GO:0006568)2.53419444
95cilium or flagellum-dependent cell motility (GO:0001539)2.51388855
96response to lipoprotein particle (GO:0055094)2.49166848
97negative regulation of blood vessel endothelial cell migration (GO:0043537)2.47941706
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47861141
99muscle atrophy (GO:0014889)2.47333085
100ribosome biogenesis (GO:0042254)2.47282695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.23666168
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.75264834
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.70392771
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.67837778
5VDR_21846776_ChIP-Seq_THP-1_Human2.47410898
6LXR_22292898_ChIP-Seq_THP-1_Human2.36046493
7* P68_20966046_ChIP-Seq_HELA_Human2.34590219
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24482791
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22015014
10* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15215776
11MAF_26560356_Chip-Seq_TH2_Human2.14026051
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.13581507
13MYC_22102868_ChIP-Seq_BL_Human2.11993424
14* BCOR_27268052_Chip-Seq_Bcells_Human2.10210237
15* BCL6_27268052_Chip-Seq_Bcells_Human2.00976567
16YY1_22570637_ChIP-Seq_MALME-3M_Human1.99078812
17* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.95589615
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95587254
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.92611167
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90957485
21* E2F1_20622854_ChIP-Seq_HELA_Human1.86129671
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.85066341
23RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.84949627
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.76368215
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73693367
26MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72673489
27PHF8_20622854_ChIP-Seq_HELA_Human1.69434386
28UTX_26944678_Chip-Seq_JUKART_Human1.66964475
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65048019
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64906548
31* P300_27268052_Chip-Seq_Bcells_Human1.63980047
32ELF1_20517297_ChIP-Seq_JURKAT_Human1.61210464
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59477092
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49129377
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48734695
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47722200
37CTCF_20526341_ChIP-Seq_ESCs_Human1.45292922
38TP53_22127205_ChIP-Seq_IMR90_Human1.44902943
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41285371
40MAF_26560356_Chip-Seq_TH1_Human1.39390381
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39233910
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.39023661
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37097665
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36894473
45* SMC4_20622854_ChIP-Seq_HELA_Human1.36701117
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33971916
47TAF2_19829295_ChIP-Seq_ESCs_Human1.33334503
48PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32651778
49* STAT1_20625510_ChIP-Seq_HELA_Human1.32148703
50SA1_27219007_Chip-Seq_Bcells_Human1.31784590
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29761715
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.29755786
53VDR_24763502_ChIP-Seq_THP-1_Human1.29272811
54CTCF_27219007_Chip-Seq_Bcells_Human1.28987467
55P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.27726828
56ERA_21632823_ChIP-Seq_H3396_Human1.27574371
57CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27157848
58SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26746676
59TP63_22573176_ChIP-Seq_HFKS_Human1.26462528
60MYB_26560356_Chip-Seq_TH2_Human1.25341326
61NANOG_20526341_ChIP-Seq_ESCs_Human1.24250603
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22394769
63ETS1_21867929_ChIP-Seq_TH2_Mouse1.22323955
64OCT4_20526341_ChIP-Seq_ESCs_Human1.21865327
65CTCF_26484167_Chip-Seq_Bcells_Mouse1.21275887
66RARB_24833708_ChIP-Seq_LIVER_Mouse1.21149157
67RAC3_21632823_ChIP-Seq_H3396_Human1.20449437
68SCL_19346495_ChIP-Seq_HPC-7_Human1.20439601
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.19846116
70FLI1_21867929_ChIP-Seq_CD8_Mouse1.19052538
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18190046
72STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18042924
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17290617
74SPI1_23547873_ChIP-Seq_NB4_Human1.15285974
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.15282230
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13761518
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11847998
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11713722
79RARA_24833708_ChIP-Seq_LIVER_Mouse1.11316442
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10144270
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.09370217
82* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09002244
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08029441
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07578677
85FOXH1_21741376_ChIP-Seq_ESCs_Human1.07546216
86RACK7_27058665_Chip-Seq_MCF-7_Human1.07383875
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06172126
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04762923
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04725248
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03504382
91* OCT4_19829295_ChIP-Seq_ESCs_Human1.03412976
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02748580
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02740312
94MYB_26560356_Chip-Seq_TH1_Human1.02633304
95NCOR1_26117541_ChIP-Seq_K562_Human1.01437966
96GATA3_26560356_Chip-Seq_TH2_Human0.99735189
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99054587
98* GABP_19822575_ChIP-Seq_HepG2_Human0.99012345
99TCF7_22412390_ChIP-Seq_EML_Mouse0.98491513
100* FOXP1_21924763_ChIP-Seq_HESCs_Human0.98443354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.74844660
2MP0003724_increased_susceptibility_to3.57673010
3MP0003183_abnormal_peptide_metabolism3.55083921
4MP0005670_abnormal_white_adipose3.17441021
5MP0005646_abnormal_pituitary_gland2.71034314
6MP0000013_abnormal_adipose_tissue2.57065557
7MP0005671_abnormal_response_to2.48565552
8MP0003705_abnormal_hypodermis_morpholog2.45176849
9MP0002138_abnormal_hepatobiliary_system2.41301563
10MP0005377_hearing/vestibular/ear_phenot2.12859897
11MP0003878_abnormal_ear_physiology2.12859897
12MP0001800_abnormal_humoral_immune2.09026739
13MP0008995_early_reproductive_senescence2.08772507
14MP0004381_abnormal_hair_follicle2.01624608
15MP0002254_reproductive_system_inflammat1.99407053
16MP0001986_abnormal_taste_sensitivity1.97594825
17MP0001661_extended_life_span1.92213570
18MP0005000_abnormal_immune_tolerance1.91777538
19MP0009785_altered_susceptibility_to1.90814219
20MP0003806_abnormal_nucleotide_metabolis1.90626092
21MP0002723_abnormal_immune_serum1.89427963
22MP0000371_diluted_coat_color1.88871008
23MP0003436_decreased_susceptibility_to1.87770478
24MP0002736_abnormal_nociception_after1.87256838
25MP0005075_abnormal_melanosome_morpholog1.86387208
26MP0002148_abnormal_hypersensitivity_rea1.82107541
27MP0005410_abnormal_fertilization1.69032407
28MP0002452_abnormal_antigen_presenting1.67427691
29MP0001790_abnormal_immune_system1.65031411
30MP0005387_immune_system_phenotype1.65031411
31MP0001968_abnormal_touch/_nociception1.64694425
32MP0002095_abnormal_skin_pigmentation1.63944963
33MP0002132_abnormal_respiratory_system1.61820894
34MP0004885_abnormal_endolymph1.61341154
35MP0005174_abnormal_tail_pigmentation1.60966554
36MP0001835_abnormal_antigen_presentation1.59582070
37MP0005025_abnormal_response_to1.57126925
38MP0009333_abnormal_splenocyte_physiolog1.55209876
39MP0003763_abnormal_thymus_physiology1.51872550
40MP0002420_abnormal_adaptive_immunity1.51267693
41MP0001819_abnormal_immune_cell1.50658183
42MP0002419_abnormal_innate_immunity1.50514634
43MP0000685_abnormal_immune_system1.46894246
44MP0000003_abnormal_adipose_tissue1.43936021
45MP0001533_abnormal_skeleton_physiology1.42021951
46MP0008872_abnormal_physiological_respon1.39379186
47MP0005171_absent_coat_pigmentation1.38499153
48MP0005551_abnormal_eye_electrophysiolog1.36400080
49MP0004130_abnormal_muscle_cell1.35179439
50MP0005083_abnormal_biliary_tract1.34234783
51MP0001764_abnormal_homeostasis1.33310698
52MP0009764_decreased_sensitivity_to1.27446448
53MP0000015_abnormal_ear_pigmentation1.26338115
54MP0002396_abnormal_hematopoietic_system1.25209704
55MP0000716_abnormal_immune_system1.21974414
56MP0002837_dystrophic_cardiac_calcinosis1.21725959
57MP0004947_skin_inflammation1.19726258
58MP0002938_white_spotting1.19138586
59MP0002398_abnormal_bone_marrow1.17513255
60MP0004147_increased_porphyrin_level1.17465100
61MP0000703_abnormal_thymus_morphology1.16765515
62MP0003172_abnormal_lysosome_physiology1.16760463
63MP0001845_abnormal_inflammatory_respons1.16588176
64MP0003646_muscle_fatigue1.16425439
65MP0001873_stomach_inflammation1.15295272
66MP0005332_abnormal_amino_acid1.10916336
67MP0002653_abnormal_ependyma_morphology1.10113948
68MP0002405_respiratory_system_inflammati1.06415176
69MP0008469_abnormal_protein_level1.05570937
70MP0004185_abnormal_adipocyte_glucose1.04710445
71MP0001919_abnormal_reproductive_system1.04457149
72MP0002429_abnormal_blood_cell1.01792173
73MP0002933_joint_inflammation1.01428390
74MP0005310_abnormal_salivary_gland1.01094242
75MP0002075_abnormal_coat/hair_pigmentati0.99771132
76MP0002722_abnormal_immune_system0.98294899
77MP0000689_abnormal_spleen_morphology0.97518097
78MP0003045_fibrosis0.96233352
79MP0005167_abnormal_blood-brain_barrier0.95881865
80MP0003136_yellow_coat_color0.95309738
81MP0001348_abnormal_lacrimal_gland0.93751994
82MP0009643_abnormal_urine_homeostasis0.92146250
83MP0005058_abnormal_lysosome_morphology0.88131907
84MP0000470_abnormal_stomach_morphology0.86746864
85MP0001944_abnormal_pancreas_morphology0.82161009
86MP0001502_abnormal_circadian_rhythm0.81643484
87MP0010155_abnormal_intestine_physiology0.78991588
88MP0005367_renal/urinary_system_phenotyp0.77930273
89MP0000516_abnormal_urinary_system0.77930273
90MP0002163_abnormal_gland_morphology0.77313503
91MP0008875_abnormal_xenobiotic_pharmacok0.77312400
92MP0002693_abnormal_pancreas_physiology0.76460117
93MP0005076_abnormal_cell_differentiation0.76005094
94MP0000372_irregular_coat_pigmentation0.75880092
95MP0004043_abnormal_pH_regulation0.75763758
96MP0000538_abnormal_urinary_bladder0.75287378
97MP0000367_abnormal_coat/_hair0.75194633
98MP0002160_abnormal_reproductive_system0.74608626
99MP0003195_calcinosis0.74515449
100MP0002136_abnormal_kidney_physiology0.72606001

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.84124994
2Abnormality of alanine metabolism (HP:0010916)6.84124994
3Hyperalaninemia (HP:0003348)6.84124994
4Constricted visual fields (HP:0001133)5.30652956
5Congenital sensorineural hearing impairment (HP:0008527)4.98976756
6Spontaneous hematomas (HP:0007420)4.96265971
7Elevated erythrocyte sedimentation rate (HP:0003565)4.64036456
8Decreased electroretinogram (ERG) amplitude (HP:0000654)4.48058062
9Anorexia (HP:0002039)4.17461076
10Attenuation of retinal blood vessels (HP:0007843)4.02765438
11Esophageal varix (HP:0002040)3.99903496
12Myositis (HP:0100614)3.80137003
13White forelock (HP:0002211)3.52975893
14Pendular nystagmus (HP:0012043)3.28760093
15Pulmonary embolism (HP:0002204)3.27287626
16Myocardial infarction (HP:0001658)3.04327694
17Birth length less than 3rd percentile (HP:0003561)2.97486611
18Homocystinuria (HP:0002156)2.96190003
19Abnormality of homocysteine metabolism (HP:0010919)2.96190003
20Patchy hypopigmentation of hair (HP:0011365)2.92496409
21Chronic otitis media (HP:0000389)2.91967743
22Pustule (HP:0200039)2.91643592
23Hemoptysis (HP:0002105)2.84607548
24Chronic hepatic failure (HP:0100626)2.81734109
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80749192
26Pigmentary retinal degeneration (HP:0001146)2.77102206
27Chorioretinal atrophy (HP:0000533)2.73850695
28Arterial thrombosis (HP:0004420)2.71166617
29Congenital stationary night blindness (HP:0007642)2.66333969
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.62331800
31Optic neuritis (HP:0100653)2.59669674
32Retrobulbar optic neuritis (HP:0100654)2.59669674
33Abnormality of the fetal cardiovascular system (HP:0010948)2.49534233
34Abnormal umbilical cord blood vessels (HP:0011403)2.49534233
35Single umbilical artery (HP:0001195)2.49534233
36Orchitis (HP:0100796)2.45059549
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44828898
38Recurrent abscess formation (HP:0002722)2.36749010
39Petechiae (HP:0000967)2.33655372
40Poor speech (HP:0002465)2.32982341
41Abnormality of DNA repair (HP:0003254)2.28947765
42Cheilitis (HP:0100825)2.23347512
43Gastrointestinal infarctions (HP:0005244)2.22200847
44Duplicated collecting system (HP:0000081)2.22065711
45Stomatitis (HP:0010280)2.21053021
46Hypergammaglobulinemia (HP:0010702)2.20764619
47Recurrent bacterial skin infections (HP:0005406)2.20366493
48Fatigue (HP:0012378)2.19124889
49Severe visual impairment (HP:0001141)2.18360124
50Increased cerebral lipofuscin (HP:0011813)2.17585075
51Abnormality of the renal collecting system (HP:0004742)2.16407435
52Conjunctival telangiectasia (HP:0000524)2.12838615
53Oligomenorrhea (HP:0000876)2.12825366
54Premature graying of hair (HP:0002216)2.07208213
55Tetany (HP:0001281)2.07020142
56Generalized aminoaciduria (HP:0002909)2.06650130
57Abnormal rod and cone electroretinograms (HP:0008323)2.05684840
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.04332151
59Hypertensive crisis (HP:0100735)2.03985659
60Thrombophlebitis (HP:0004418)2.03506770
61Biconcave vertebral bodies (HP:0004586)1.93342020
62Myopathic facies (HP:0002058)1.93089573
63Heterochromia iridis (HP:0001100)1.92412430
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90718588
65Granulocytopenia (HP:0001913)1.90528433
66Absent thumb (HP:0009777)1.90349593
67Vasculitis (HP:0002633)1.86659452
68Cortical visual impairment (HP:0100704)1.85524274
69Conjugated hyperbilirubinemia (HP:0002908)1.82714287
70Leukopenia (HP:0001882)1.82342285
71Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82150320
72Visceral angiomatosis (HP:0100761)1.80763805
73Brittle hair (HP:0002299)1.80528371
74Photophobia (HP:0000613)1.77507740
75Microcytic anemia (HP:0001935)1.77438156
76Keratoconus (HP:0000563)1.77239464
77Increased corneal curvature (HP:0100692)1.77239464
78Abnormality of serum amino acid levels (HP:0003112)1.76184649
79Ileus (HP:0002595)1.75089411
80Abnormality of the pericardium (HP:0001697)1.73185157
81Peritonitis (HP:0002586)1.72841764
82Abnormal respiratory motile cilium morphology (HP:0005938)1.72708620
83Abnormal respiratory epithelium morphology (HP:0012253)1.72708620
84Gingival bleeding (HP:0000225)1.69425648
85Decreased subcutaneous fat (HP:0001002)1.68805462
86Cone-rod dystrophy (HP:0000548)1.67517765
87Type II diabetes mellitus (HP:0005978)1.66656058
88Hypopigmentation of the fundus (HP:0007894)1.64926735
89Abnormality of eosinophils (HP:0001879)1.64819107
90Action tremor (HP:0002345)1.64556801
91Concave nail (HP:0001598)1.61844138
92Abolished electroretinogram (ERG) (HP:0000550)1.61752177
93Type I diabetes mellitus (HP:0100651)1.61552022
94Vacuolated lymphocytes (HP:0001922)1.61335173
95Abnormality of the hepatic vasculature (HP:0006707)1.59309462
96Hypergonadotropic hypogonadism (HP:0000815)1.58816289
97Arteriovenous malformation (HP:0100026)1.57683836
98Recurrent fungal infections (HP:0002841)1.57570588
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.57186132
100Chronic sinusitis (HP:0011109)1.57153163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K34.42178223
2MAP3K34.02398281
3MAP4K13.67088164
4JAK33.17554255
5TXK3.09250255
6ACVR1B2.69542863
7TLK12.43198706
8FRK2.38424079
9ADRBK22.38015375
10MAPK152.26223711
11FGR2.23271571
12IKBKB2.06035773
13CDK91.74617430
14RPS6KB21.74184675
15IRAK41.71815391
16GRK61.57984893
17SIK21.57286806
18MAP4K21.53053159
19MAP3K111.51489420
20ERN11.45714506
21IRAK31.41963630
22NTRK21.41023009
23ADRBK11.39662793
24TBK11.39225325
25TAOK31.38829333
26MAP3K141.38403487
27SIK11.26330923
28ZAK1.22330579
29TRIB31.20546091
30GRK11.20402731
31TNK21.20269279
32INSRR1.19539210
33TESK21.12522108
34BLK1.09452832
35IKBKE1.09316371
36MAP2K61.02717456
37MAP3K131.01770964
38TYRO30.99844117
39CHUK0.98629865
40WNK40.96323638
41BTK0.95375526
42SYK0.94491628
43ZAP700.93788943
44PRKCI0.93539804
45CSK0.92603973
46PRKD20.91401081
47LCK0.90422407
48PRKCQ0.89389119
49MUSK0.88783758
50SGK4940.87763750
51SGK2230.87763750
52MAP2K20.87470996
53PIM20.86165536
54KDR0.84505911
55ITK0.83953626
56PTK60.82017279
57RPS6KA60.81532124
58MAP2K10.77691807
59PASK0.76766516
60IRAK10.74233948
61EPHB20.72152959
62HIPK20.71872769
63RPS6KA10.71679386
64LYN0.68454645
65RPS6KL10.67294782
66RPS6KC10.67294782
67GRK70.65636038
68CDC42BPA0.65614317
69FES0.65475223
70SMG10.64607030
71MTOR0.63464939
72MAPK110.63268393
73SIK30.59114600
74KIT0.58007893
75RIPK40.57924323
76PDPK10.57729880
77EPHA20.55588909
78TYK20.53099953
79NEK60.52565472
80SGK30.51785597
81JAK20.48734161
82SGK20.47391421
83PRKCD0.47358268
84DYRK1B0.46660604
85TEC0.46204084
86IRAK20.46020292
87BMPR1B0.45646429
88BCKDK0.44966054
89CAMKK10.44419515
90HCK0.44166135
91CSNK1A10.42455916
92PIM10.41971312
93RPS6KA20.41883702
94PINK10.40833444
95PRKAA20.37548317
96PRKD10.37463621
97PDK10.37454376
98PRKCH0.36895652
99CDK70.35605745
100NUAK10.35399633

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.36591301
2One carbon pool by folate_Homo sapiens_hsa006703.12396659
3Other glycan degradation_Homo sapiens_hsa005112.90598747
4Primary immunodeficiency_Homo sapiens_hsa053402.58286526
5Collecting duct acid secretion_Homo sapiens_hsa049662.54940893
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34206870
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14738795
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.11717941
9Sulfur metabolism_Homo sapiens_hsa009202.07598030
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93960272
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.93349549
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.90156331
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.86405431
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85090064
15Selenocompound metabolism_Homo sapiens_hsa004501.82673989
16Graft-versus-host disease_Homo sapiens_hsa053321.80035048
17Morphine addiction_Homo sapiens_hsa050321.77741581
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63096857
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58197724
20Rheumatoid arthritis_Homo sapiens_hsa053231.58118863
21Osteoclast differentiation_Homo sapiens_hsa043801.54843379
22Arginine biosynthesis_Homo sapiens_hsa002201.47276506
23Regulation of autophagy_Homo sapiens_hsa041401.47209878
24Galactose metabolism_Homo sapiens_hsa000521.45966408
25Allograft rejection_Homo sapiens_hsa053301.44019306
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41568461
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40707574
28Autoimmune thyroid disease_Homo sapiens_hsa053201.33021598
29T cell receptor signaling pathway_Homo sapiens_hsa046601.32663944
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28569406
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25656506
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19539646
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19218685
34TNF signaling pathway_Homo sapiens_hsa046681.14228630
35Type I diabetes mellitus_Homo sapiens_hsa049401.12581923
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11869982
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11714187
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.10283681
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08741330
40ABC transporters_Homo sapiens_hsa020101.08120847
41Hematopoietic cell lineage_Homo sapiens_hsa046401.07050693
42Lysosome_Homo sapiens_hsa041421.06008971
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.05649789
44Measles_Homo sapiens_hsa051621.02060881
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02030430
46Chemokine signaling pathway_Homo sapiens_hsa040620.98746580
47GABAergic synapse_Homo sapiens_hsa047270.98384930
48Phototransduction_Homo sapiens_hsa047440.97791408
49Antigen processing and presentation_Homo sapiens_hsa046120.95736736
50B cell receptor signaling pathway_Homo sapiens_hsa046620.94907015
51Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94452949
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.92926079
53Linoleic acid metabolism_Homo sapiens_hsa005910.92748520
54Sphingolipid metabolism_Homo sapiens_hsa006000.92644042
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91576356
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87089102
57Ether lipid metabolism_Homo sapiens_hsa005650.85818082
58Asthma_Homo sapiens_hsa053100.85379499
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83732161
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81698474
61Influenza A_Homo sapiens_hsa051640.79501778
62Fatty acid biosynthesis_Homo sapiens_hsa000610.78329954
63Vitamin digestion and absorption_Homo sapiens_hsa049770.77946999
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77674243
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76209822
66Herpes simplex infection_Homo sapiens_hsa051680.73198052
67Serotonergic synapse_Homo sapiens_hsa047260.73013554
68Nicotine addiction_Homo sapiens_hsa050330.72417278
69Leishmaniasis_Homo sapiens_hsa051400.72179703
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69407834
71Nitrogen metabolism_Homo sapiens_hsa009100.68522134
72Staphylococcus aureus infection_Homo sapiens_hsa051500.66260800
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65491600
74Legionellosis_Homo sapiens_hsa051340.64883124
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.64562739
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.64001362
77African trypanosomiasis_Homo sapiens_hsa051430.62175767
78Taste transduction_Homo sapiens_hsa047420.60485876
79Acute myeloid leukemia_Homo sapiens_hsa052210.60366094
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59903172
81Olfactory transduction_Homo sapiens_hsa047400.58350936
82Homologous recombination_Homo sapiens_hsa034400.58136043
83Cholinergic synapse_Homo sapiens_hsa047250.57878256
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57618946
85Tuberculosis_Homo sapiens_hsa051520.52930957
86Basal transcription factors_Homo sapiens_hsa030220.52836931
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.52025536
88Fanconi anemia pathway_Homo sapiens_hsa034600.50861367
89Pertussis_Homo sapiens_hsa051330.47165856
90Malaria_Homo sapiens_hsa051440.45674896
91Apoptosis_Homo sapiens_hsa042100.43190933
92Vibrio cholerae infection_Homo sapiens_hsa051100.42419511
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41535249
94mRNA surveillance pathway_Homo sapiens_hsa030150.40869123
95Tryptophan metabolism_Homo sapiens_hsa003800.40867019
96Glutamatergic synapse_Homo sapiens_hsa047240.38842657
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37755302
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36883164
99Circadian entrainment_Homo sapiens_hsa047130.36029871
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34577244

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