ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.56487095
2	neural tube formation (GO:0001841)	4.30673779
3	DNA double-strand break processing (GO:0000729)	4.13442866
4	presynaptic membrane assembly (GO:0097105)	3.72793774
5	behavioral response to nicotine (GO:0035095)	3.69044518
6	nucleobase catabolic process (GO:0046113)	3.68346346
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.51943882
8	response to pheromone (GO:0019236)	3.51827992
9	auditory behavior (GO:0031223)	3.47357366
10	protein localization to cilium (GO:0061512)	3.38688915
11	presynaptic membrane organization (GO:0097090)	3.38218420
12	gamma-aminobutyric acid transport (GO:0015812)	3.25428851
13	L-fucose catabolic process (GO:0042355)	3.24871994
14	fucose catabolic process (GO:0019317)	3.24871994
15	L-fucose metabolic process (GO:0042354)	3.24871994
16	olfactory bulb development (GO:0021772)	3.21647731
17	epithelial cilium movement (GO:0003351)	3.19473016
18	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.18774868
19	forebrain neuron differentiation (GO:0021879)	3.16299281
20	protein polyglutamylation (GO:0018095)	3.13879105
21	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.11476318
22	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.11476318
23	regulation of translation, ncRNA-mediated (GO:0045974)	3.11476318
24	startle response (GO:0001964)	3.11445955
25	cilium morphogenesis (GO:0060271)	3.10001147
26	mechanosensory behavior (GO:0007638)	3.09655588
27	somite development (GO:0061053)	3.05470065
28	reflex (GO:0060004)	3.02585192
29	neuron cell-cell adhesion (GO:0007158)	2.97864552
30	ubiquinone metabolic process (GO:0006743)	2.96052694
31	intraciliary transport (GO:0042073)	2.94190701
32	nonmotile primary cilium assembly (GO:0035058)	2.93800772
33	DNA integration (GO:0015074)	2.89923064
34	negative regulation of DNA recombination (GO:0045910)	2.85218073
35	head development (GO:0060322)	2.85154369
36	regulation of telomere maintenance (GO:0032204)	2.84828706
37	positive regulation of mitochondrial fission (GO:0090141)	2.84090112
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.83719710
39	neuronal action potential propagation (GO:0019227)	2.80754303
40	cochlea development (GO:0090102)	2.80453059
41	innervation (GO:0060384)	2.76969892
42	cilium or flagellum-dependent cell motility (GO:0001539)	2.76620292
43	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.75297951
44	cilium organization (GO:0044782)	2.74596102
45	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.74140669
46	limb bud formation (GO:0060174)	2.73873101
47	synapse assembly (GO:0007416)	2.73729654
48	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.73553733
49	regulation of mitotic spindle checkpoint (GO:1903504)	2.72587459
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.72587459
51	cilium assembly (GO:0042384)	2.70922228
52	protein localization to synapse (GO:0035418)	2.66526122
53	replication fork processing (GO:0031297)	2.65669251
54	cornea development in camera-type eye (GO:0061303)	2.65393318
55	histone H2A acetylation (GO:0043968)	2.64144941
56	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.63863418
57	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.63748514
58	negative regulation of telomere maintenance (GO:0032205)	2.62065644
59	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.61362322
60	indolalkylamine metabolic process (GO:0006586)	2.60815102
61	establishment of protein localization to Golgi (GO:0072600)	2.60504600
62	postsynaptic membrane organization (GO:0001941)	2.59483680
63	protein K11-linked deubiquitination (GO:0035871)	2.58816034
64	retinal ganglion cell axon guidance (GO:0031290)	2.57918737
65	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.57530777
66	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.57460689
67	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.57460689
68	vocalization behavior (GO:0071625)	2.56475555
69	cilium movement (GO:0003341)	2.56207723
70	ncRNA catabolic process (GO:0034661)	2.54929258
71	sympathetic nervous system development (GO:0048485)	2.52951258
72	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.51705609
73	kynurenine metabolic process (GO:0070189)	2.51116733
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.51071053
75	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50901518
76	histone H3-K9 methylation (GO:0051567)	2.49099234
77	organelle disassembly (GO:1903008)	2.47231678
78	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.46710442
79	ubiquinone biosynthetic process (GO:0006744)	2.46258582
80	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45950220
81	axoneme assembly (GO:0035082)	2.45136382
82	microtubule anchoring (GO:0034453)	2.44126610
83	glycosphingolipid biosynthetic process (GO:0006688)	2.44022007
84	regulation of collateral sprouting (GO:0048670)	2.40773425
85	dendritic spine morphogenesis (GO:0060997)	2.40203780
86	prenylation (GO:0097354)	2.39459212
87	protein prenylation (GO:0018342)	2.39459212
88	protein targeting to Golgi (GO:0000042)	2.37602068
89	transmission of nerve impulse (GO:0019226)	2.37586102
90	GPI anchor metabolic process (GO:0006505)	2.37301419
91	regulation of cilium movement (GO:0003352)	2.37283543
92	axonal fasciculation (GO:0007413)	2.36502173
93	platelet dense granule organization (GO:0060155)	2.36239640
94	resolution of meiotic recombination intermediates (GO:0000712)	2.35661400
95	behavioral response to ethanol (GO:0048149)	2.34207195
96	neurotransmitter-gated ion channel clustering (GO:0072578)	2.33615740
97	central nervous system projection neuron axonogenesis (GO:0021952)	2.33606410
98	DNA deamination (GO:0045006)	2.33303475
99	neuron recognition (GO:0008038)	2.33258636
100	regulation of development, heterochronic (GO:0040034)	2.32531952

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.69123273
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.25901824
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.09705095
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.02333835
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.01050860
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.96022378
7	VDR_22108803_ChIP-Seq_LS180_Human	2.90655990
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.86044852
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69545877
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.62730975
11	FUS_26573619_Chip-Seq_HEK293_Human	2.49263822
12	EWS_26573619_Chip-Seq_HEK293_Human	2.44996980
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.31350278
14	P300_19829295_ChIP-Seq_ESCs_Human	2.30485769
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28464923
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.26018878
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11632912
18	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.00746303
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00033190
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96716256
21	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92421696
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.87390115
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.82334030
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79058825
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.70657425
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67311536
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66974502
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65322588
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65236579
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64815645
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63097413
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.59954638
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56174940
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.54461974
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54461974
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54161530
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.54059726
38	STAT3_23295773_ChIP-Seq_U87_Human	1.53996366
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.52795094
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49982975
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49484451
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47965378
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45877905
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45877905
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45548347
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44823706
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42733462
48	AR_25329375_ChIP-Seq_VCAP_Human	1.41727059
49	TCF4_23295773_ChIP-Seq_U87_Human	1.38362520
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35297808
51	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.34638652
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34398138
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34229314
54	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.33840259
55	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.32631508
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.31386748
57	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.31309829
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30792270
59	* MYC_18940864_ChIP-ChIP_HL60_Human	1.30433304
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30321472
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29593605
62	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29250106
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28743200
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28615563
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28119104
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27715879
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25883765
68	BCAT_22108803_ChIP-Seq_LS180_Human	1.23713256
69	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23226343
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.21465153
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20403182
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20236568
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.18726425
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17839578
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17691192
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.16539201
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15811809
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15811809
79	VDR_23849224_ChIP-Seq_CD4+_Human	1.13284338
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12639773
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11768160
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10340326
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10324255
84	JUN_21703547_ChIP-Seq_K562_Human	1.09655373
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09123163
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07923625
87	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07308015
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05015987
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04722561
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01613353
91	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01172857
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00805127
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00225753
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99059003
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98844965
96	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.97936037
97	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.97699591
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97123647
99	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97005744
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96641957

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.35266542
2	MP0003787_abnormal_imprinting	3.27992641
3	MP0003122_maternal_imprinting	3.01614992
4	MP0005645_abnormal_hypothalamus_physiol	2.95833346
5	MP0003121_genomic_imprinting	2.81600319
6	MP0003880_abnormal_central_pattern	2.68033381
7	MP0002102_abnormal_ear_morphology	2.50570102
8	MP0001984_abnormal_olfaction	2.35170230
9	MP0000569_abnormal_digit_pigmentation	2.28308097
10	MP0006072_abnormal_retinal_apoptosis	2.13842596
11	MP0008995_early_reproductive_senescence	2.12371847
12	MP0001529_abnormal_vocalization	2.07961885
13	MP0006276_abnormal_autonomic_nervous	2.01084387
14	MP0000778_abnormal_nervous_system	1.98540392
15	MP0009046_muscle_twitch	1.96807187
16	MP0004133_heterotaxia	1.90653658
17	MP0003890_abnormal_embryonic-extraembry	1.88790266
18	MP0005253_abnormal_eye_physiology	1.80465496
19	MP0001486_abnormal_startle_reflex	1.78935632
20	MP0009745_abnormal_behavioral_response	1.78754355
21	MP0001968_abnormal_touch/_nociception	1.76957868
22	MP0005551_abnormal_eye_electrophysiolog	1.73238557
23	MP0006292_abnormal_olfactory_placode	1.70699967
24	MP0002272_abnormal_nervous_system	1.68999330
25	MP0004142_abnormal_muscle_tone	1.67718740
26	MP0002736_abnormal_nociception_after	1.62537135
27	MP0008789_abnormal_olfactory_epithelium	1.61922797
28	MP0003635_abnormal_synaptic_transmissio	1.60214617
29	MP0005423_abnormal_somatic_nervous	1.55299183
30	MP0002751_abnormal_autonomic_nervous	1.53289672
31	MP0004147_increased_porphyrin_level	1.51477079
32	MP0005394_taste/olfaction_phenotype	1.50643265
33	MP0005499_abnormal_olfactory_system	1.50643265
34	MP0002572_abnormal_emotion/affect_behav	1.49445095
35	MP0008058_abnormal_DNA_repair	1.49229164
36	MP0000631_abnormal_neuroendocrine_gland	1.47614900
37	MP0004859_abnormal_synaptic_plasticity	1.47103332
38	MP0002653_abnormal_ependyma_morphology	1.46960509
39	MP0001188_hyperpigmentation	1.46837575
40	MP0002735_abnormal_chemical_nociception	1.44181121
41	MP0002063_abnormal_learning/memory/cond	1.43299395
42	MP0004885_abnormal_endolymph	1.41574586
43	MP0002638_abnormal_pupillary_reflex	1.40923373
44	MP0002064_seizures	1.34380660
45	MP0002067_abnormal_sensory_capabilities	1.33681233
46	MP0002557_abnormal_social/conspecific_i	1.31843589
47	MP0001485_abnormal_pinna_reflex	1.30590159
48	MP0003195_calcinosis	1.28873678
49	MP0004270_analgesia	1.28753545
50	MP0001986_abnormal_taste_sensitivity	1.28735513
51	MP0002184_abnormal_innervation	1.26894018
52	MP0000427_abnormal_hair_cycle	1.25842533
53	MP0003136_yellow_coat_color	1.24955039
54	MP0002734_abnormal_mechanical_nocicepti	1.23420979
55	MP0003119_abnormal_digestive_system	1.21787384
56	MP0002234_abnormal_pharynx_morphology	1.21338523
57	MP0005386_behavior/neurological_phenoty	1.20995443
58	MP0004924_abnormal_behavior	1.20995443
59	MP0004742_abnormal_vestibular_system	1.18325021
60	MP0003567_abnormal_fetal_cardiomyocyte	1.16781178
61	MP0004043_abnormal_pH_regulation	1.16367452
62	MP0000955_abnormal_spinal_cord	1.15440942
63	MP0001293_anophthalmia	1.15410621
64	MP0003937_abnormal_limbs/digits/tail_de	1.15279519
65	MP0000372_irregular_coat_pigmentation	1.14975162
66	MP0002837_dystrophic_cardiac_calcinosis	1.13301430
67	MP0008872_abnormal_physiological_respon	1.08681493
68	MP0002752_abnormal_somatic_nervous	1.06830542
69	MP0001501_abnormal_sleep_pattern	1.05218710
70	MP0000049_abnormal_middle_ear	1.03902931
71	MP0005187_abnormal_penis_morphology	1.02539975
72	MP0002882_abnormal_neuron_morphology	1.01276571
73	MP0000647_abnormal_sebaceous_gland	1.00122012
74	MP0001970_abnormal_pain_threshold	0.99540602
75	MP0003221_abnormal_cardiomyocyte_apopto	0.99122386
76	MP0003786_premature_aging	0.99091930
77	MP0001502_abnormal_circadian_rhythm	0.98187941
78	MP0008057_abnormal_DNA_replication	0.96746693
79	MP0009697_abnormal_copulation	0.96011087
80	MP0002938_white_spotting	0.95717351
81	MP0002928_abnormal_bile_duct	0.94878558
82	MP0002233_abnormal_nose_morphology	0.94654401
83	MP0002733_abnormal_thermal_nociception	0.93762675
84	MP0005646_abnormal_pituitary_gland	0.92995115
85	MP0004811_abnormal_neuron_physiology	0.92917130
86	MP0001177_atelectasis	0.92621979
87	MP0005195_abnormal_posterior_eye	0.92090896
88	MP0005391_vision/eye_phenotype	0.90264058
89	MP0003698_abnormal_male_reproductive	0.86893729
90	MP0002152_abnormal_brain_morphology	0.86500921
91	MP0005367_renal/urinary_system_phenotyp	0.85829158
92	MP0000516_abnormal_urinary_system	0.85829158
93	MP0004215_abnormal_myocardial_fiber	0.85716979
94	MP0003646_muscle_fatigue	0.83697878
95	MP0002095_abnormal_skin_pigmentation	0.83524384
96	MP0003137_abnormal_impulse_conducting	0.83159782
97	MP0000026_abnormal_inner_ear	0.82930326
98	MP0003861_abnormal_nervous_system	0.81412242
99	MP0002822_catalepsy	0.81288067
100	MP0000383_abnormal_hair_follicle	0.80807415

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.70067304
2	True hermaphroditism (HP:0010459)	3.41845117
3	Pancreatic fibrosis (HP:0100732)	3.35841464
4	Molar tooth sign on MRI (HP:0002419)	3.19524135
5	Abnormality of midbrain morphology (HP:0002418)	3.19524135
6	Colon cancer (HP:0003003)	3.13009466
7	Abnormality of the labia minora (HP:0012880)	3.06066809
8	Chronic hepatic failure (HP:0100626)	3.03592043
9	Polyphagia (HP:0002591)	3.03409901
10	Medial flaring of the eyebrow (HP:0010747)	2.99192025
11	Nephronophthisis (HP:0000090)	2.98823700
12	Gait imbalance (HP:0002141)	2.82619233
13	Intestinal atresia (HP:0011100)	2.72341356
14	Hyperventilation (HP:0002883)	2.71861177
15	Congenital primary aphakia (HP:0007707)	2.69869401
16	Abnormality of the renal medulla (HP:0100957)	2.69133510
17	Nephrogenic diabetes insipidus (HP:0009806)	2.62056518
18	Abnormality of the renal cortex (HP:0011035)	2.57166737
19	Febrile seizures (HP:0002373)	2.54994598
20	Progressive inability to walk (HP:0002505)	2.53600228
21	Lissencephaly (HP:0001339)	2.48203316
22	Drooling (HP:0002307)	2.46878295
23	Genital tract atresia (HP:0001827)	2.45764791
24	Vaginal atresia (HP:0000148)	2.45362252
25	Volvulus (HP:0002580)	2.42345879
26	Failure to thrive in infancy (HP:0001531)	2.42183737
27	Broad-based gait (HP:0002136)	2.36201250
28	Inability to walk (HP:0002540)	2.33966033
29	Thyroid-stimulating hormone excess (HP:0002925)	2.31015808
30	Renal cortical cysts (HP:0000803)	2.29809619
31	Progressive cerebellar ataxia (HP:0002073)	2.29136681
32	Absent speech (HP:0001344)	2.28830294
33	Optic nerve hypoplasia (HP:0000609)	2.26960404
34	Atonic seizures (HP:0010819)	2.26580629
35	Type II lissencephaly (HP:0007260)	2.26098665
36	Excessive salivation (HP:0003781)	2.24599767
37	Sclerocornea (HP:0000647)	2.23942790
38	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.22100551
39	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.22100551
40	Genetic anticipation (HP:0003743)	2.17785551
41	Hypothermia (HP:0002045)	2.17607251
42	Abnormal hair whorl (HP:0010721)	2.17392065
43	Gaze-evoked nystagmus (HP:0000640)	2.16803373
44	Protruding tongue (HP:0010808)	2.15119817
45	Focal motor seizures (HP:0011153)	2.14816095
46	Congenital stationary night blindness (HP:0007642)	2.14530473
47	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.11934786
48	Oligodactyly (hands) (HP:0001180)	2.11111893
49	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.10876083
50	Abnormality of alanine metabolism (HP:0010916)	2.10876083
51	Hyperalaninemia (HP:0003348)	2.10876083
52	Pendular nystagmus (HP:0012043)	2.09015770
53	Glioma (HP:0009733)	2.08608131
54	Specific learning disability (HP:0001328)	2.03099810
55	Retinal dysplasia (HP:0007973)	2.02943861
56	Methylmalonic acidemia (HP:0002912)	2.01612088
57	Cystic liver disease (HP:0006706)	2.01272602
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.01156108
59	Dialeptic seizures (HP:0011146)	2.00302810
60	Abnormality of the astrocytes (HP:0100707)	2.00259928
61	Astrocytoma (HP:0009592)	2.00259928
62	Poor coordination (HP:0002370)	2.00130022
63	Narrow forehead (HP:0000341)	1.98913427
64	Small hand (HP:0200055)	1.98505111
65	Limb dystonia (HP:0002451)	1.97246481
66	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.96146254
67	Abolished electroretinogram (ERG) (HP:0000550)	1.94337177
68	Anencephaly (HP:0002323)	1.93569355
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.92864463
70	Stomach cancer (HP:0012126)	1.92405977
71	Abnormality of the corticospinal tract (HP:0002492)	1.89750730
72	Hepatoblastoma (HP:0002884)	1.88988529
73	Neoplasm of the adrenal cortex (HP:0100641)	1.88175200
74	Postaxial hand polydactyly (HP:0001162)	1.87602510
75	Postaxial foot polydactyly (HP:0001830)	1.86697986
76	Amyotrophic lateral sclerosis (HP:0007354)	1.85971139
77	Medulloblastoma (HP:0002885)	1.85938395
78	Septo-optic dysplasia (HP:0100842)	1.84655902
79	Focal seizures (HP:0007359)	1.82496174
80	Male pseudohermaphroditism (HP:0000037)	1.80961004
81	Patellar aplasia (HP:0006443)	1.80322978
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.79617797
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.79617797
84	Hyperglycinemia (HP:0002154)	1.78302377
85	Abnormality of chromosome stability (HP:0003220)	1.78109956
86	Abnormality of the ileum (HP:0001549)	1.77024545
87	Epileptic encephalopathy (HP:0200134)	1.76631981
88	Dyskinesia (HP:0100660)	1.75913330
89	Congenital hepatic fibrosis (HP:0002612)	1.75389629
90	3-Methylglutaconic aciduria (HP:0003535)	1.75377874
91	Dandy-Walker malformation (HP:0001305)	1.73534234
92	Broad foot (HP:0001769)	1.73463195
93	Abnormal biliary tract physiology (HP:0012439)	1.72869669
94	Bile duct proliferation (HP:0001408)	1.72869669
95	Micropenis (HP:0000054)	1.72249498
96	Pachygyria (HP:0001302)	1.71962744
97	Meckel diverticulum (HP:0002245)	1.71843857
98	Supernumerary spleens (HP:0009799)	1.70923232
99	Attenuation of retinal blood vessels (HP:0007843)	1.70586327
100	Agitation (HP:0000713)	1.70411593

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.52592205
2	TRIM28	3.19597442
3	CASK	3.17210247
4	MAP3K4	3.08887566
5	BCR	3.07970164
6	WNK3	2.98212226
7	MAP2K7	2.58400791
8	MAPK13	2.34722715
9	MARK1	2.34073375
10	BMPR1B	2.30868913
11	MAP4K2	2.24876646
12	MKNK2	2.21100375
13	NUAK1	1.98120515
14	ZAK	1.80366478
15	ERBB3	1.80087258
16	SRPK1	1.76318258
17	ACVR1B	1.73200239
18	PINK1	1.71312166
19	ADRBK2	1.60667443
20	TNIK	1.56458284
21	MKNK1	1.51926814
22	SIK3	1.44525206
23	DYRK2	1.40332433
24	CSNK1G2	1.38855635
25	TAOK3	1.38080328
26	PAK3	1.31709166
27	CSNK1G1	1.31413836
28	CSNK1A1L	1.29254025
29	CSNK1G3	1.27827041
30	GRK1	1.24401781
31	PNCK	1.21895076
32	EPHA4	1.18755292
33	CAMKK2	1.18401455
34	DYRK3	1.16243528
35	MINK1	1.13883248
36	MAP2K4	1.13306439
37	WNK4	1.12516350
38	NTRK2	1.10413532
39	INSRR	1.06693773
40	STK38L	1.05383375
41	OXSR1	1.05340657
42	TSSK6	1.04348174
43	EPHA3	1.01562812
44	PLK2	0.96739905
45	STK39	0.96199697
46	PKN1	0.92992976
47	DAPK2	0.89693305
48	PIK3CA	0.85062218
49	NTRK3	0.84549847
50	PLK3	0.84123355
51	PLK4	0.83490756
52	DYRK1A	0.82517970
53	TXK	0.81647907
54	VRK1	0.81113998
55	BRSK2	0.79390135
56	PRKCE	0.76778442
57	AKT3	0.74494021
58	PRKCG	0.74292528
59	UHMK1	0.74017538
60	BCKDK	0.72421106
61	BRD4	0.71649429
62	WEE1	0.68016962
63	SGK2	0.67780405
64	RPS6KA4	0.60680974
65	FGFR2	0.60026648
66	CAMK2A	0.58117850
67	ATR	0.54396645
68	SGK223	0.53426120
69	SGK494	0.53426120
70	CDK19	0.53052310
71	MAP3K6	0.50526805
72	PLK1	0.48631380
73	ADRBK1	0.46287132
74	TAF1	0.45431172
75	CAMK1	0.45422898
76	CSNK1D	0.45356917
77	ATM	0.45115395
78	CAMK4	0.44569040
79	CDK5	0.43129227
80	CSNK1A1	0.41374950
81	CDC7	0.40178885
82	TGFBR1	0.40009104
83	ERBB2	0.38958952
84	TEC	0.37369540
85	IRAK1	0.36292692
86	KSR1	0.35557960
87	PRKCQ	0.35439569
88	PRKACA	0.34731067
89	NLK	0.34357409
90	TLK1	0.33381280
91	FER	0.33215611
92	TIE1	0.31801797
93	PRKG1	0.31737955
94	DYRK1B	0.30888977
95	EIF2AK3	0.30040857
96	SIK2	0.29792381
97	FGFR1	0.29012628
98	RPS6KA5	0.28969643
99	CAMK1G	0.28602424
100	STK11	0.27598193

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.98781518
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.10427395
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.64126098
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.63515932
5	Phototransduction_Homo sapiens_hsa04744	2.48613548
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.42805167
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.41469975
8	Protein export_Homo sapiens_hsa03060	2.39200174
9	Butanoate metabolism_Homo sapiens_hsa00650	2.38590144
10	GABAergic synapse_Homo sapiens_hsa04727	2.18360212
11	Basal transcription factors_Homo sapiens_hsa03022	2.15190637
12	Steroid biosynthesis_Homo sapiens_hsa00100	2.11559988
13	Morphine addiction_Homo sapiens_hsa05032	1.96795302
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.95793900
15	Propanoate metabolism_Homo sapiens_hsa00640	1.95415814
16	Taste transduction_Homo sapiens_hsa04742	1.92128002
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89143428
18	Homologous recombination_Homo sapiens_hsa03440	1.75676847
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.72828342
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71665187
21	RNA degradation_Homo sapiens_hsa03018	1.70766915
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.62034191
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60947229
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.58134412
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51530678
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50460457
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.48125940
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.39833742
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.33412943
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.32045610
31	Circadian entrainment_Homo sapiens_hsa04713	1.31942175
32	RNA polymerase_Homo sapiens_hsa03020	1.31222674
33	Olfactory transduction_Homo sapiens_hsa04740	1.30446640
34	Dopaminergic synapse_Homo sapiens_hsa04728	1.28522832
35	Regulation of autophagy_Homo sapiens_hsa04140	1.22292459
36	Serotonergic synapse_Homo sapiens_hsa04726	1.22127849
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.18831526
38	Peroxisome_Homo sapiens_hsa04146	1.14931069
39	Oxidative phosphorylation_Homo sapiens_hsa00190	1.13053730
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12994664
41	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.00550603
42	Amphetamine addiction_Homo sapiens_hsa05031	0.96844945
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96328463
44	Parkinsons disease_Homo sapiens_hsa05012	0.94927261
45	Cocaine addiction_Homo sapiens_hsa05030	0.94661542
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.93841291
47	mRNA surveillance pathway_Homo sapiens_hsa03015	0.92682901
48	RNA transport_Homo sapiens_hsa03013	0.91431674
49	Insulin secretion_Homo sapiens_hsa04911	0.89174792
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88884127
51	Caffeine metabolism_Homo sapiens_hsa00232	0.84926326
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84645356
53	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.82702688
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76141865
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76017391
56	Oocyte meiosis_Homo sapiens_hsa04114	0.75004635
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.74773743
58	Axon guidance_Homo sapiens_hsa04360	0.74527406
59	Long-term depression_Homo sapiens_hsa04730	0.74270745
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74128439
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73142903
62	ABC transporters_Homo sapiens_hsa02010	0.67806625
63	Huntingtons disease_Homo sapiens_hsa05016	0.64337412
64	Mismatch repair_Homo sapiens_hsa03430	0.63699055
65	Spliceosome_Homo sapiens_hsa03040	0.62626339
66	Circadian rhythm_Homo sapiens_hsa04710	0.61299974
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58079394
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.57121877
69	Alcoholism_Homo sapiens_hsa05034	0.55347673
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54495286
71	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.53882426
72	Salivary secretion_Homo sapiens_hsa04970	0.52187350
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.51413187
74	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50983932
75	Purine metabolism_Homo sapiens_hsa00230	0.48288715
76	Cholinergic synapse_Homo sapiens_hsa04725	0.48271228
77	Basal cell carcinoma_Homo sapiens_hsa05217	0.48139796
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.48139713
79	Lysine degradation_Homo sapiens_hsa00310	0.47899821
80	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.47883488
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47817578
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.47272496
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.46811671
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.44824631
85	Base excision repair_Homo sapiens_hsa03410	0.43684461
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41996412
87	Metabolic pathways_Homo sapiens_hsa01100	0.41942762
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40732595
89	Retinol metabolism_Homo sapiens_hsa00830	0.39716799
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.38641095
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35107737
92	Alzheimers disease_Homo sapiens_hsa05010	0.34253845
93	One carbon pool by folate_Homo sapiens_hsa00670	0.32900593
94	Cardiac muscle contraction_Homo sapiens_hsa04260	0.32863219
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32447218
96	Cell cycle_Homo sapiens_hsa04110	0.30195940
97	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29884129
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.29812563
99	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.29050764
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28804254

ZNF708

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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