ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.03083013
2	nucleobase catabolic process (GO:0046113)	4.33601274
3	retinal ganglion cell axon guidance (GO:0031290)	3.99815345
4	intraciliary transport (GO:0042073)	3.98842156
5	protein K11-linked deubiquitination (GO:0035871)	3.97906687
6	response to pheromone (GO:0019236)	3.96101445
7	protein polyglutamylation (GO:0018095)	3.90882246
8	regulation of cilium movement (GO:0003352)	3.64226997
9	gamma-aminobutyric acid transport (GO:0015812)	3.62094369
10	presynaptic membrane assembly (GO:0097105)	3.56563619
11	replication fork processing (GO:0031297)	3.50778573
12	DNA double-strand break processing (GO:0000729)	3.38614840
13	epithelial cilium movement (GO:0003351)	3.30723470
14	cilium organization (GO:0044782)	3.27526468
15	cilium assembly (GO:0042384)	3.26660594
16	histone H2A acetylation (GO:0043968)	3.24049408
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.22339269
18	axonal fasciculation (GO:0007413)	3.18395633
19	DNA integration (GO:0015074)	3.13649810
20	synapsis (GO:0007129)	3.12627329
21	neuronal action potential propagation (GO:0019227)	3.11820876
22	righting reflex (GO:0060013)	3.10128773
23	protein localization to cilium (GO:0061512)	3.06911325
24	neuron recognition (GO:0008038)	3.04226762
25	cilium morphogenesis (GO:0060271)	3.01111729
26	cilium movement (GO:0003341)	2.99518680
27	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.99477018
28	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.99477018
29	regulation of translation, ncRNA-mediated (GO:0045974)	2.99477018
30	glycosphingolipid biosynthetic process (GO:0006688)	2.98676202
31	oxidative demethylation (GO:0070989)	2.97689183
32	cerebral cortex radially oriented cell migration (GO:0021799)	2.96170549
33	head development (GO:0060322)	2.95622284
34	presynaptic membrane organization (GO:0097090)	2.93808815
35	positive regulation of mitochondrial fission (GO:0090141)	2.93551813
36	behavioral response to ethanol (GO:0048149)	2.93141515
37	acrosome reaction (GO:0007340)	2.91645963
38	regulation of collateral sprouting (GO:0048670)	2.89450854
39	negative regulation of axon guidance (GO:1902668)	2.89440831
40	negative regulation of DNA recombination (GO:0045910)	2.88806630
41	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.87681695
42	centriole replication (GO:0007099)	2.85935071
43	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.85147897
44	neural tube formation (GO:0001841)	2.85099352
45	neuron cell-cell adhesion (GO:0007158)	2.82318303
46	reflex (GO:0060004)	2.82272360
47	axoneme assembly (GO:0035082)	2.79268302
48	neurotransmitter-gated ion channel clustering (GO:0072578)	2.78383593
49	olfactory bulb development (GO:0021772)	2.78145730
50	nonmotile primary cilium assembly (GO:0035058)	2.76215880
51	photoreceptor cell maintenance (GO:0045494)	2.75201071
52	auditory behavior (GO:0031223)	2.73692681
53	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.72843837
54	postsynaptic membrane organization (GO:0001941)	2.71466581
55	cullin deneddylation (GO:0010388)	2.70911689
56	microtubule depolymerization (GO:0007019)	2.69464637
57	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.68052528
58	regulation of telomere maintenance (GO:0032204)	2.66067026
59	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.64989916
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.64634730
61	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.63631189
62	limb bud formation (GO:0060174)	2.63393048
63	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.63158208
64	cell migration in hindbrain (GO:0021535)	2.61933832
65	cellular component assembly involved in morphogenesis (GO:0010927)	2.61550005
66	negative regulation of dendrite development (GO:2000171)	2.61051633
67	DNA ligation (GO:0006266)	2.59425005
68	cilium or flagellum-dependent cell motility (GO:0001539)	2.56325561
69	vocalization behavior (GO:0071625)	2.55333265
70	startle response (GO:0001964)	2.52279545
71	positive regulation of amino acid transport (GO:0051957)	2.51870088
72	resolution of meiotic recombination intermediates (GO:0000712)	2.51637843
73	striatum development (GO:0021756)	2.50588672
74	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.48510165
75	behavioral response to nicotine (GO:0035095)	2.47837898
76	transmission of nerve impulse (GO:0019226)	2.47114392
77	DNA demethylation (GO:0080111)	2.46703029
78	regulation of Rac GTPase activity (GO:0032314)	2.46526941
79	spermatid nucleus differentiation (GO:0007289)	2.45410709
80	glycerophospholipid catabolic process (GO:0046475)	2.44107116
81	protein localization to peroxisome (GO:0072662)	2.43575934
82	protein targeting to peroxisome (GO:0006625)	2.43575934
83	establishment of protein localization to peroxisome (GO:0072663)	2.43575934
84	regulation of heat generation (GO:0031650)	2.43480785
85	protein import into peroxisome matrix (GO:0016558)	2.42364354
86	somite development (GO:0061053)	2.41306581
87	cell wall macromolecule catabolic process (GO:0016998)	2.41114408
88	mechanosensory behavior (GO:0007638)	2.38822282
89	synapse assembly (GO:0007416)	2.38553680
90	hindbrain development (GO:0030902)	2.37338616
91	regulation of microtubule-based movement (GO:0060632)	2.36531696
92	central nervous system projection neuron axonogenesis (GO:0021952)	2.36059891
93	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.35658940
94	regulation of mitotic spindle checkpoint (GO:1903504)	2.35658940
95	regulation of dendritic spine development (GO:0060998)	2.35294900
96	regulation of sarcomere organization (GO:0060297)	2.34770570
97	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.34336889
98	respiratory chain complex IV assembly (GO:0008535)	2.32117063
99	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.30986545
100	piRNA metabolic process (GO:0034587)	2.30604952

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.35402373
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.34654700
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.29409630
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.11495153
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.05883134
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.93559286
7	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.92927539
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.83137829
9	FUS_26573619_Chip-Seq_HEK293_Human	2.68008270
10	VDR_22108803_ChIP-Seq_LS180_Human	2.56423213
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.55233659
12	EWS_26573619_Chip-Seq_HEK293_Human	2.30174006
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23985334
14	P300_19829295_ChIP-Seq_ESCs_Human	2.15126840
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05218689
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.97923067
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94731586
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.89555774
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.89034169
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86748786
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86137608
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.84328944
23	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.82511978
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.82412537
25	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82287607
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.79067816
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77547723
28	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.77349625
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.76459095
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.71662299
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70414396
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.68730163
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.67100625
34	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60915075
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.56983170
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.56647705
37	* STAT3_23295773_ChIP-Seq_U87_Human	1.53570027
38	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.51637403
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.51403979
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51151998
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.49821110
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45334634
43	EZH2_22144423_ChIP-Seq_EOC_Human	1.45222524
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43168723
45	TCF4_23295773_ChIP-Seq_U87_Human	1.41991561
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41921807
47	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41749977
48	* CBP_20019798_ChIP-Seq_JUKART_Human	1.41749977
49	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41713863
50	AR_25329375_ChIP-Seq_VCAP_Human	1.41456849
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.41390806
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.40687250
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38835175
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36155440
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35553603
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34111511
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34111511
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33891817
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32168841
60	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30252938
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.28421166
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28274134
63	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.26716222
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25523673
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24519534
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.23047815
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22347978
68	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.21158860
69	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20353078
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20350327
71	ELK1_19687146_ChIP-ChIP_HELA_Human	1.17825095
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16685345
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16404557
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16404557
75	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14294721
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.13891905
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13011368
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11195437
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.10628696
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10176560
81	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10161393
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09555288
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07723030
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.07350542
85	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07279672
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06674437
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06657370
88	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.04103425
89	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.03513502
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03089160
91	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02562946
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02369538
93	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00860506
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00139716
95	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.99535797
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98768267
97	JUN_21703547_ChIP-Seq_K562_Human	0.98228902
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98187527
99	VDR_23849224_ChIP-Seq_CD4+_Human	0.97612943
100	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97180133

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.13777478
2	MP0002102_abnormal_ear_morphology	3.11577346
3	MP0001529_abnormal_vocalization	2.92831629
4	MP0003880_abnormal_central_pattern	2.82827638
5	MP0000569_abnormal_digit_pigmentation	2.76366405
6	MP0003122_maternal_imprinting	2.52637386
7	MP0003787_abnormal_imprinting	2.48678847
8	MP0001984_abnormal_olfaction	2.46140575
9	MP0004270_analgesia	2.39915275
10	MP0003121_genomic_imprinting	2.36187900
11	MP0000778_abnormal_nervous_system	2.10736835
12	MP0004859_abnormal_synaptic_plasticity	2.09098105
13	MP0005551_abnormal_eye_electrophysiolog	2.05400696
14	MP0009046_muscle_twitch	1.97050088
15	MP0005084_abnormal_gallbladder_morpholo	1.96306500
16	MP0008058_abnormal_DNA_repair	1.92206492
17	MP0002938_white_spotting	1.82063387
18	MP0008057_abnormal_DNA_replication	1.81685696
19	MP0001968_abnormal_touch/_nociception	1.75225554
20	MP0005394_taste/olfaction_phenotype	1.72314681
21	MP0005499_abnormal_olfactory_system	1.72314681
22	MP0008789_abnormal_olfactory_epithelium	1.69591669
23	MP0000631_abnormal_neuroendocrine_gland	1.67905574
24	MP0006292_abnormal_olfactory_placode	1.64869899
25	MP0009745_abnormal_behavioral_response	1.63309668
26	MP0005253_abnormal_eye_physiology	1.58510842
27	MP0001293_anophthalmia	1.57680261
28	MP0001486_abnormal_startle_reflex	1.57154737
29	MP0006072_abnormal_retinal_apoptosis	1.56408845
30	MP0003635_abnormal_synaptic_transmissio	1.49794108
31	MP0002735_abnormal_chemical_nociception	1.47125597
32	MP0003718_maternal_effect	1.46708109
33	MP0005248_abnormal_Harderian_gland	1.44590999
34	MP0002734_abnormal_mechanical_nocicepti	1.44432116
35	MP0001986_abnormal_taste_sensitivity	1.41313451
36	MP0010094_abnormal_chromosome_stability	1.40407973
37	MP0004142_abnormal_muscle_tone	1.38861378
38	MP0005367_renal/urinary_system_phenotyp	1.38518100
39	MP0000516_abnormal_urinary_system	1.38518100
40	MP0002736_abnormal_nociception_after	1.38514546
41	MP0005423_abnormal_somatic_nervous	1.37107937
42	MP0002837_dystrophic_cardiac_calcinosis	1.37093750
43	MP0002638_abnormal_pupillary_reflex	1.35052017
44	MP0004924_abnormal_behavior	1.34564616
45	MP0005386_behavior/neurological_phenoty	1.34564616
46	MP0002063_abnormal_learning/memory/cond	1.33788410
47	MP0004133_heterotaxia	1.33629785
48	MP0000427_abnormal_hair_cycle	1.30966564
49	MP0002928_abnormal_bile_duct	1.30672961
50	MP0002272_abnormal_nervous_system	1.28148505
51	MP0002233_abnormal_nose_morphology	1.27610362
52	MP0002572_abnormal_emotion/affect_behav	1.26353260
53	MP0008995_early_reproductive_senescence	1.26097455
54	MP0002751_abnormal_autonomic_nervous	1.24894922
55	MP0006276_abnormal_autonomic_nervous	1.22393471
56	MP0002557_abnormal_social/conspecific_i	1.21582610
57	MP0003786_premature_aging	1.16075135
58	MP0002822_catalepsy	1.15582734
59	MP0003195_calcinosis	1.11538456
60	MP0003937_abnormal_limbs/digits/tail_de	1.09619502
61	MP0002184_abnormal_innervation	1.08141767
62	MP0002064_seizures	1.06936478
63	MP0003698_abnormal_male_reproductive	1.06719724
64	MP0004147_increased_porphyrin_level	1.06580417
65	MP0005646_abnormal_pituitary_gland	1.05555298
66	MP0000955_abnormal_spinal_cord	1.00978309
67	MP0002234_abnormal_pharynx_morphology	1.00221470
68	MP0001501_abnormal_sleep_pattern	0.99583293
69	MP0001929_abnormal_gametogenesis	0.99550092
70	MP0004811_abnormal_neuron_physiology	0.99472677
71	MP0001485_abnormal_pinna_reflex	0.98967079
72	MP0000647_abnormal_sebaceous_gland	0.97778007
73	MP0003137_abnormal_impulse_conducting	0.97486982
74	MP0002752_abnormal_somatic_nervous	0.95397609
75	MP0005391_vision/eye_phenotype	0.94552679
76	MP0003861_abnormal_nervous_system	0.94293225
77	MP0002882_abnormal_neuron_morphology	0.93321505
78	MP0001177_atelectasis	0.93067474
79	MP0002067_abnormal_sensory_capabilities	0.92621937
80	MP0002152_abnormal_brain_morphology	0.91353984
81	MP0005187_abnormal_penis_morphology	0.90744826
82	MP0003119_abnormal_digestive_system	0.87304329
83	MP0002090_abnormal_vision	0.86576754
84	MP0004043_abnormal_pH_regulation	0.85633088
85	MP0005195_abnormal_posterior_eye	0.85041854
86	MP0004215_abnormal_myocardial_fiber	0.85005067
87	MP0010678_abnormal_skin_adnexa	0.83659541
88	MP0001905_abnormal_dopamine_level	0.83480513
89	MP0002160_abnormal_reproductive_system	0.82811627
90	MP0008872_abnormal_physiological_respon	0.78045913
91	MP0003755_abnormal_palate_morphology	0.77638907
92	MP0010234_abnormal_vibrissa_follicle	0.76921184
93	MP0009697_abnormal_copulation	0.76549347
94	MP0000653_abnormal_sex_gland	0.74812088
95	MP0005410_abnormal_fertilization	0.74536936
96	MP0002210_abnormal_sex_determination	0.73712957
97	MP0000383_abnormal_hair_follicle	0.73689567
98	MP0001970_abnormal_pain_threshold	0.73603409
99	MP0005395_other_phenotype	0.72398511
100	MP0002876_abnormal_thyroid_physiology	0.71887826

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	4.21471024
2	Pancreatic cysts (HP:0001737)	4.00933656
3	Pancreatic fibrosis (HP:0100732)	3.76950882
4	Abnormality of midbrain morphology (HP:0002418)	3.65217296
5	Molar tooth sign on MRI (HP:0002419)	3.65217296
6	True hermaphroditism (HP:0010459)	3.56534528
7	Nephronophthisis (HP:0000090)	3.42359330
8	Medial flaring of the eyebrow (HP:0010747)	3.33341418
9	Volvulus (HP:0002580)	3.07232810
10	Gait imbalance (HP:0002141)	3.04808837
11	Tubulointerstitial nephritis (HP:0001970)	2.99291136
12	Absent speech (HP:0001344)	2.99216244
13	Congenital primary aphakia (HP:0007707)	2.96026326
14	Genital tract atresia (HP:0001827)	2.90668120
15	Abnormality of the renal medulla (HP:0100957)	2.90648135
16	Abnormality of the labia minora (HP:0012880)	2.88092630
17	Progressive inability to walk (HP:0002505)	2.81668934
18	Nephrogenic diabetes insipidus (HP:0009806)	2.79758209
19	Vaginal atresia (HP:0000148)	2.79659415
20	Abnormality of the renal cortex (HP:0011035)	2.74374180
21	Renal cortical cysts (HP:0000803)	2.70191616
22	Methylmalonic acidemia (HP:0002912)	2.58947540
23	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.55624755
24	Type II lissencephaly (HP:0007260)	2.50734491
25	Neoplasm of the oral cavity (HP:0100649)	2.48351162
26	Narrow forehead (HP:0000341)	2.47308059
27	Bile duct proliferation (HP:0001408)	2.45681949
28	Abnormal biliary tract physiology (HP:0012439)	2.45681949
29	Lissencephaly (HP:0001339)	2.42923760
30	Cystic liver disease (HP:0006706)	2.38800591
31	Large for gestational age (HP:0001520)	2.35135980
32	Hyperventilation (HP:0002883)	2.35037617
33	Occipital encephalocele (HP:0002085)	2.32902610
34	Hip dysplasia (HP:0001385)	2.29494449
35	Postaxial foot polydactyly (HP:0001830)	2.24980780
36	Intestinal atresia (HP:0011100)	2.21558836
37	Postaxial hand polydactyly (HP:0001162)	2.20663567
38	Amyotrophic lateral sclerosis (HP:0007354)	2.20317565
39	Retinal dysplasia (HP:0007973)	2.19788142
40	Osteomalacia (HP:0002749)	2.19247225
41	Exotropia (HP:0000577)	2.18589934
42	Drooling (HP:0002307)	2.13039495
43	Abnormality of the dental root (HP:0006486)	2.12107609
44	Taurodontia (HP:0000679)	2.12107609
45	Abnormality of permanent molar morphology (HP:0011071)	2.12107609
46	Methylmalonic aciduria (HP:0012120)	2.11112390
47	Abnormality of renal resorption (HP:0011038)	2.10396487
48	Poor coordination (HP:0002370)	2.05977908
49	Inability to walk (HP:0002540)	2.05668483
50	Preaxial hand polydactyly (HP:0001177)	2.03571324
51	Hypothermia (HP:0002045)	2.03365951
52	Proximal tubulopathy (HP:0000114)	2.02995887
53	Abnormality of vitamin metabolism (HP:0100508)	2.00537585
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.99377396
55	Abnormality of vitamin B metabolism (HP:0004340)	1.99051358
56	Anencephaly (HP:0002323)	1.98712648
57	Focal motor seizures (HP:0011153)	1.97868897
58	Aplasia/Hypoplasia of the lens (HP:0008063)	1.97270019
59	Prominent nasal bridge (HP:0000426)	1.95160682
60	Optic nerve coloboma (HP:0000588)	1.94387355
61	Abnormality of the dental pulp (HP:0006479)	1.94082256
62	Colon cancer (HP:0003003)	1.91853049
63	Highly arched eyebrow (HP:0002553)	1.91846555
64	Brushfield spots (HP:0001088)	1.91819333
65	Excessive salivation (HP:0003781)	1.91075790
66	Abnormality of molar (HP:0011077)	1.90920109
67	Abnormality of molar morphology (HP:0011070)	1.90920109
68	Protruding tongue (HP:0010808)	1.90118848
69	Abnormal lung lobation (HP:0002101)	1.87078872
70	Sclerocornea (HP:0000647)	1.86513478
71	Polyphagia (HP:0002591)	1.84606934
72	Abnormal ciliary motility (HP:0012262)	1.83435561
73	Congenital stationary night blindness (HP:0007642)	1.83387934
74	Optic nerve hypoplasia (HP:0000609)	1.81656984
75	Tubulointerstitial abnormality (HP:0001969)	1.81526133
76	Oligodactyly (hands) (HP:0001180)	1.81299646
77	Broad-based gait (HP:0002136)	1.80095060
78	Progressive cerebellar ataxia (HP:0002073)	1.79419628
79	Cupped ear (HP:0000378)	1.77662018
80	Febrile seizures (HP:0002373)	1.76896237
81	Short tibia (HP:0005736)	1.76748654
82	Oculomotor apraxia (HP:0000657)	1.76745831
83	Limb dystonia (HP:0002451)	1.76708029
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.76070480
85	Absent/shortened dynein arms (HP:0200106)	1.76070480
86	Furrowed tongue (HP:0000221)	1.75937907
87	Poor suck (HP:0002033)	1.75413243
88	Widely spaced teeth (HP:0000687)	1.75166276
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.75135752
90	Renal hypoplasia (HP:0000089)	1.74974061
91	Tubular atrophy (HP:0000092)	1.74116203
92	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.73645770
93	Pachygyria (HP:0001302)	1.73588813
94	Midline defect of the nose (HP:0004122)	1.73314050
95	Meckel diverticulum (HP:0002245)	1.72390425
96	Cerebellar dysplasia (HP:0007033)	1.72243650
97	Abnormality of the ileum (HP:0001549)	1.70354083
98	Pendular nystagmus (HP:0012043)	1.69950102
99	Congenital hepatic fibrosis (HP:0002612)	1.67837654
100	Stomach cancer (HP:0012126)	1.66824687

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.10328956
2	FRK	4.06876913
3	MAP3K4	2.77746764
4	CASK	2.66698893
5	EPHA4	2.52166085
6	TRIM28	2.49809732
7	MARK1	2.41700179
8	PNCK	2.34929652
9	TNIK	2.34893759
10	BMPR1B	2.22464806
11	MAP2K7	2.21012716
12	BCR	2.19038977
13	BRD4	2.17677312
14	MAPK13	2.15287454
15	MKNK2	2.14801984
16	MAP4K2	2.13146935
17	ERBB3	1.92114050
18	EIF2AK3	1.78751330
19	BRSK2	1.77928153
20	SRPK1	1.64917187
21	PLK4	1.63178727
22	FGFR2	1.59945662
23	CCNB1	1.51069202
24	ACVR1B	1.47130165
25	WEE1	1.41632939
26	MINK1	1.41062666
27	PLK3	1.40811816
28	MKNK1	1.39706483
29	CSNK1G1	1.27695204
30	CSNK1G2	1.26827713
31	NUAK1	1.23348140
32	TIE1	1.21316581
33	CSNK1G3	1.19474218
34	DYRK2	1.16731666
35	PINK1	1.13413891
36	CAMKK2	1.12051712
37	ZAK	1.11912577
38	TSSK6	1.11584053
39	INSRR	1.10262424
40	CSNK1A1L	1.08823444
41	STK39	1.05306599
42	ADRBK2	0.99979728
43	PAK3	0.99579028
44	GRK1	0.96144231
45	NTRK3	0.92806933
46	PRKCG	0.91455337
47	MARK3	0.88806083
48	PLK1	0.87688370
49	PLK2	0.85007553
50	STK3	0.84581827
51	NTRK2	0.84069489
52	PRKCE	0.83812339
53	OXSR1	0.82970345
54	STK16	0.81346790
55	TTK	0.81149172
56	STK38L	0.78374328
57	TGFBR1	0.75619330
58	DYRK1A	0.74691915
59	EPHA3	0.70258083
60	KSR1	0.69092382
61	TAOK3	0.66820080
62	VRK1	0.66171306
63	DYRK3	0.62503741
64	ATR	0.61155092
65	CDK5	0.59678234
66	STK11	0.58427987
67	MAP2K4	0.57793283
68	ATM	0.56063296
69	UHMK1	0.52771806
70	PKN1	0.52377198
71	PRKCZ	0.50703882
72	CAMK2A	0.49832682
73	CAMK1G	0.48984592
74	DAPK2	0.48127573
75	TAOK1	0.47758433
76	CSNK1D	0.46005110
77	CSNK1A1	0.45903321
78	CDK14	0.43453555
79	BUB1	0.42880790
80	EIF2AK2	0.41535836
81	CDK18	0.39779504
82	STK38	0.39389630
83	FLT3	0.38557498
84	WNK4	0.38239955
85	CDK9	0.35648987
86	OBSCN	0.35489928
87	ADRBK1	0.34778537
88	PHKG1	0.34667442
89	PHKG2	0.34667442
90	CSNK1E	0.34494940
91	PRKACB	0.33758228
92	CDK15	0.33402735
93	CDC7	0.33072962
94	PRKCI	0.31697628
95	PRKAA1	0.30789401
96	CDK1	0.30355914
97	RPS6KA4	0.30170558
98	PRKACA	0.29668742
99	BRSK1	0.28892348
100	FGFR1	0.28691520

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.88079023
2	Phototransduction_Homo sapiens_hsa04744	2.85251781
3	Protein export_Homo sapiens_hsa03060	2.70704928
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.67659843
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.66646319
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.60660370
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.47845417
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.41109724
9	Nicotine addiction_Homo sapiens_hsa05033	2.38499385
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.27740450
11	Butanoate metabolism_Homo sapiens_hsa00650	2.25208058
12	Propanoate metabolism_Homo sapiens_hsa00640	2.07003625
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.77752700
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.74008599
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.62492994
16	Taste transduction_Homo sapiens_hsa04742	1.54969514
17	GABAergic synapse_Homo sapiens_hsa04727	1.54389087
18	Homologous recombination_Homo sapiens_hsa03440	1.53966151
19	RNA degradation_Homo sapiens_hsa03018	1.52230572
20	Basal transcription factors_Homo sapiens_hsa03022	1.49230426
21	Circadian rhythm_Homo sapiens_hsa04710	1.47698050
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.46219762
23	Circadian entrainment_Homo sapiens_hsa04713	1.43294593
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.41556102
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.41043533
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38441496
27	Morphine addiction_Homo sapiens_hsa05032	1.34713405
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34613968
29	Dopaminergic synapse_Homo sapiens_hsa04728	1.33226727
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.24180786
31	Peroxisome_Homo sapiens_hsa04146	1.23723810
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.20595644
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19086178
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.17497312
35	Oocyte meiosis_Homo sapiens_hsa04114	1.11509615
36	Sulfur metabolism_Homo sapiens_hsa00920	1.08962587
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.07238540
38	Folate biosynthesis_Homo sapiens_hsa00790	1.05110207
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03397400
40	Insulin secretion_Homo sapiens_hsa04911	1.03387232
41	Regulation of autophagy_Homo sapiens_hsa04140	1.02812330
42	Caffeine metabolism_Homo sapiens_hsa00232	0.97943173
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96120759
44	Olfactory transduction_Homo sapiens_hsa04740	0.94632937
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.94507376
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93935663
47	Amphetamine addiction_Homo sapiens_hsa05031	0.91948547
48	Cocaine addiction_Homo sapiens_hsa05030	0.91666965
49	Base excision repair_Homo sapiens_hsa03410	0.90126939
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89409839
51	Mismatch repair_Homo sapiens_hsa03430	0.89365641
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88181976
53	p53 signaling pathway_Homo sapiens_hsa04115	0.87886306
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86873437
55	Long-term depression_Homo sapiens_hsa04730	0.83502559
56	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.79696106
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78471945
58	RNA transport_Homo sapiens_hsa03013	0.78448779
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77934122
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74126613
61	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.72761967
62	ABC transporters_Homo sapiens_hsa02010	0.72520663
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.71899758
64	Lysine degradation_Homo sapiens_hsa00310	0.71009292
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67862708
66	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67831759
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67539031
68	Purine metabolism_Homo sapiens_hsa00230	0.66100071
69	Salivary secretion_Homo sapiens_hsa04970	0.63832151
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62874130
71	Fatty acid elongation_Homo sapiens_hsa00062	0.62598722
72	Oxidative phosphorylation_Homo sapiens_hsa00190	0.61810105
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60394149
74	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.60191627
75	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.59390071
76	Hippo signaling pathway_Homo sapiens_hsa04390	0.58962814
77	Serotonergic synapse_Homo sapiens_hsa04726	0.58254417
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57581145
79	Cell cycle_Homo sapiens_hsa04110	0.57066214
80	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55950216
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55691217
82	Metabolic pathways_Homo sapiens_hsa01100	0.55552485
83	Axon guidance_Homo sapiens_hsa04360	0.55113298
84	RNA polymerase_Homo sapiens_hsa03020	0.55004718
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52308947
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.52293196
87	Renin secretion_Homo sapiens_hsa04924	0.51981665
88	Parkinsons disease_Homo sapiens_hsa05012	0.51321734
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50752298
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50153535
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.49548944
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.48915980
93	Huntingtons disease_Homo sapiens_hsa05016	0.47761860
94	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.46434699
95	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45757918
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44654180
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.44216061
98	Retinol metabolism_Homo sapiens_hsa00830	0.44133830
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.43472856
100	Cholinergic synapse_Homo sapiens_hsa04725	0.40048000

ZNF709

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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