ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.60351947
2	protein prenylation (GO:0018342)	5.68573181
3	prenylation (GO:0097354)	5.68573181
4	negative regulation of Ras GTPase activity (GO:0034261)	5.33352076
5	nucleobase catabolic process (GO:0046113)	4.83323419
6	behavioral response to nicotine (GO:0035095)	4.73845349
7	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.68182210
8	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.68182210
9	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.68182210
10	L-fucose catabolic process (GO:0042355)	4.61013393
11	fucose catabolic process (GO:0019317)	4.61013393
12	L-fucose metabolic process (GO:0042354)	4.61013393
13	histone H3-K9 methylation (GO:0051567)	4.20240881
14	coenzyme A biosynthetic process (GO:0015937)	3.92770818
15	acrosome assembly (GO:0001675)	3.85758982
16	neuron cell-cell adhesion (GO:0007158)	3.82170708
17	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	3.80983099
18	protein polyglutamylation (GO:0018095)	3.80588548
19	postsynaptic membrane organization (GO:0001941)	3.73551828
20	presynaptic membrane assembly (GO:0097105)	3.67574466
21	axonal fasciculation (GO:0007413)	3.59046845
22	presynaptic membrane organization (GO:0097090)	3.49898784
23	olfactory bulb development (GO:0021772)	3.49202533
24	protein localization to synapse (GO:0035418)	3.46487475
25	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.44371533
26	negative regulation of Rho protein signal transduction (GO:0035024)	3.43762914
27	neuron recognition (GO:0008038)	3.41875503
28	peptidyl-lysine dimethylation (GO:0018027)	3.40502847
29	metallo-sulfur cluster assembly (GO:0031163)	3.36426980
30	iron-sulfur cluster assembly (GO:0016226)	3.36426980
31	eosinophil chemotaxis (GO:0048245)	3.35728620
32	DNA integration (GO:0015074)	3.35479886
33	regulation of sister chromatid cohesion (GO:0007063)	3.33450289
34	seminiferous tubule development (GO:0072520)	3.32977997
35	synapse assembly (GO:0007416)	3.28863312
36	tachykinin receptor signaling pathway (GO:0007217)	3.25694298
37	negative regulation of circadian rhythm (GO:0042754)	3.20859006
38	neurotransmitter-gated ion channel clustering (GO:0072578)	3.14325217
39	positive regulation of action potential (GO:0045760)	3.12469134
40	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.12010438
41	regulation of feeding behavior (GO:0060259)	3.11530000
42	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.10964490
43	histone H3-K9 modification (GO:0061647)	3.10419089
44	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.08669191
45	protein localization to cilium (GO:0061512)	3.04403576
46	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.03937331
47	forebrain neuron differentiation (GO:0021879)	3.02631329
48	positive regulation of mitochondrial fission (GO:0090141)	3.02041360
49	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	2.99331713
50	eosinophil migration (GO:0072677)	2.98959482
51	organ growth (GO:0035265)	2.98128704
52	regulation of action potential (GO:0098900)	2.95976601
53	regulation of gene silencing by RNA (GO:0060966)	2.91556952
54	regulation of posttranscriptional gene silencing (GO:0060147)	2.91556952
55	regulation of gene silencing by miRNA (GO:0060964)	2.91556952
56	synaptic transmission, cholinergic (GO:0007271)	2.91497508
57	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.90586732
58	oxidative demethylation (GO:0070989)	2.90384270
59	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.90166032
60	gamma-aminobutyric acid transport (GO:0015812)	2.89832487
61	branch elongation of an epithelium (GO:0060602)	2.89775575
62	somite development (GO:0061053)	2.88567111
63	ganglion development (GO:0061548)	2.87511977
64	protein import into peroxisome matrix (GO:0016558)	2.84497059
65	central nervous system projection neuron axonogenesis (GO:0021952)	2.83720149
66	preassembly of GPI anchor in ER membrane (GO:0016254)	2.83390620
67	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.83249477
68	fucosylation (GO:0036065)	2.78612159
69	nonmotile primary cilium assembly (GO:0035058)	2.77766022
70	retinal ganglion cell axon guidance (GO:0031290)	2.77701101
71	spinal cord development (GO:0021510)	2.77561275
72	negative regulation of axon guidance (GO:1902668)	2.76895763
73	vesicle fusion (GO:0006906)	2.76697467
74	DNA damage response, detection of DNA damage (GO:0042769)	2.75852755
75	positive regulation of calcium ion import (GO:0090280)	2.74126762
76	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.73717984
77	head development (GO:0060322)	2.72908912
78	peptidyl-lysine trimethylation (GO:0018023)	2.69924689
79	regulation of mononuclear cell migration (GO:0071675)	2.69770172
80	non-recombinational repair (GO:0000726)	2.68607367
81	double-strand break repair via nonhomologous end joining (GO:0006303)	2.68607367
82	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.67374566
83	behavioral response to ethanol (GO:0048149)	2.66907802
84	positive regulation of chromosome segregation (GO:0051984)	2.61406899
85	retinal cone cell development (GO:0046549)	2.61355067
86	protein sumoylation (GO:0016925)	2.60553387
87	auditory behavior (GO:0031223)	2.58802548
88	vocalization behavior (GO:0071625)	2.56898851
89	establishment of mitochondrion localization (GO:0051654)	2.56384775
90	regulation of uterine smooth muscle contraction (GO:0070472)	2.53139606
91	transmission of nerve impulse (GO:0019226)	2.52210539
92	mitochondrial RNA metabolic process (GO:0000959)	2.52145100
93	hippocampus development (GO:0021766)	2.51823236
94	protein K11-linked deubiquitination (GO:0035871)	2.51364185
95	cell migration in hindbrain (GO:0021535)	2.51018910
96	protein targeting to vacuole (GO:0006623)	2.49636154
97	protein targeting to lysosome (GO:0006622)	2.49636154
98	establishment of protein localization to vacuole (GO:0072666)	2.49636154
99	lipid particle organization (GO:0034389)	2.48618998
100	neuron migration (GO:0001764)	2.48599035

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.01567032
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.30322764
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.43918514
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.42063311
5	VDR_22108803_ChIP-Seq_LS180_Human	3.24055162
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.06770632
7	* ZNF274_21170338_ChIP-Seq_K562_Hela	2.79516027
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74886499
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59053558
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44916822
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.27418998
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20588963
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.15375311
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.09617032
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.07563978
16	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.04863366
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04863366
18	REST_21632747_ChIP-Seq_MESCs_Mouse	1.99814474
19	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.97843409
20	RNF2_27304074_Chip-Seq_NSC_Mouse	1.97014842
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92105793
22	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.86268493
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.82494635
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77492517
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.77441367
26	GATA1_22025678_ChIP-Seq_K562_Human	1.75410016
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.71737156
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.69044803
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.67428478
30	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.65064442
31	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.62416465
32	FUS_26573619_Chip-Seq_HEK293_Human	1.59657166
33	P300_19829295_ChIP-Seq_ESCs_Human	1.59534294
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.59100473
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.50513972
36	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.49139822
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.47774260
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47642774
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46964777
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.38551854
41	EWS_26573619_Chip-Seq_HEK293_Human	1.35621247
42	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.34145486
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32097730
44	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.31657231
45	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.31332770
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30724038
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.30534911
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30167256
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.27729462
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25740702
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.24520059
52	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.22995347
53	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.22995347
54	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.21952540
55	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.21803100
56	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.21321931
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.20396059
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19084449
59	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18840470
60	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18791531
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.16995872
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16813821
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15544394
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.15544394
65	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.14388710
66	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.12008739
67	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.11759674
68	STAT3_23295773_ChIP-Seq_U87_Human	1.11639405
69	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11153359
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08941600
71	* BCAT_22108803_ChIP-Seq_LS180_Human	1.08673402
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08425953
73	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.06030484
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05856720
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.05850452
76	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04995842
77	AR_25329375_ChIP-Seq_VCAP_Human	1.03841512
78	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.02844404
79	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02090286
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.00995181
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00658649
82	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99086930
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.98751289
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.97998455
85	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96582584
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.96557735
87	SOX9_26525672_Chip-Seq_HEART_Mouse	0.96214918
88	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.95994270
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95283273
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95096619
91	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.94773508
92	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94186822
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93964942
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93889564
95	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.93698384
96	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.93448812
97	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.93274735
98	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.93225641
99	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.92943331
100	MYC_18940864_ChIP-ChIP_HL60_Human	0.92922826

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	3.62504602
2	MP0003880_abnormal_central_pattern	3.55753281
3	MP0002822_catalepsy	3.32233017
4	MP0006276_abnormal_autonomic_nervous	2.95147159
5	MP0000778_abnormal_nervous_system	2.65439954
6	MP0003787_abnormal_imprinting	2.47130345
7	MP0001529_abnormal_vocalization	2.46076990
8	MP0002751_abnormal_autonomic_nervous	2.44219950
9	MP0004270_analgesia	2.26386211
10	MP0004133_heterotaxia	2.24993272
11	MP0008789_abnormal_olfactory_epithelium	2.20926647
12	MP0005394_taste/olfaction_phenotype	2.20759067
13	MP0005499_abnormal_olfactory_system	2.20759067
14	MP0008877_abnormal_DNA_methylation	2.18096194
15	MP0002638_abnormal_pupillary_reflex	2.06776936
16	MP0002102_abnormal_ear_morphology	2.05004755
17	MP0002736_abnormal_nociception_after	2.01296992
18	MP0001984_abnormal_olfaction	1.95964743
19	MP0003122_maternal_imprinting	1.94094089
20	MP0004859_abnormal_synaptic_plasticity	1.88712306
21	MP0003303_peritoneal_inflammation	1.87700351
22	MP0003635_abnormal_synaptic_transmissio	1.75766945
23	MP0002735_abnormal_chemical_nociception	1.74475777
24	MP0002184_abnormal_innervation	1.74081417
25	MP0001968_abnormal_touch/_nociception	1.69631460
26	MP0002653_abnormal_ependyma_morphology	1.68602043
27	MP0002876_abnormal_thyroid_physiology	1.60038422
28	MP0006292_abnormal_olfactory_placode	1.58025133
29	MP0002734_abnormal_mechanical_nocicepti	1.58019606
30	MP0003121_genomic_imprinting	1.57785915
31	MP0009046_muscle_twitch	1.57526377
32	MP0001293_anophthalmia	1.57275702
33	MP0000955_abnormal_spinal_cord	1.57120935
34	MP0005423_abnormal_somatic_nervous	1.56527771
35	MP0002272_abnormal_nervous_system	1.55766127
36	MP0005645_abnormal_hypothalamus_physiol	1.53653324
37	MP0004142_abnormal_muscle_tone	1.51681701
38	MP0010386_abnormal_urinary_bladder	1.51197533
39	MP0009745_abnormal_behavioral_response	1.49652568
40	MP0002063_abnormal_learning/memory/cond	1.48655273
41	MP0000049_abnormal_middle_ear	1.44522820
42	MP0002163_abnormal_gland_morphology	1.43978639
43	MP0000631_abnormal_neuroendocrine_gland	1.42496125
44	MP0003937_abnormal_limbs/digits/tail_de	1.41400780
45	MP0002572_abnormal_emotion/affect_behav	1.41007048
46	MP0004145_abnormal_muscle_electrophysio	1.38877763
47	MP0002752_abnormal_somatic_nervous	1.34990592
48	MP0002882_abnormal_neuron_morphology	1.33902956
49	MP0005253_abnormal_eye_physiology	1.31478087
50	MP0004811_abnormal_neuron_physiology	1.30895753
51	MP0002557_abnormal_social/conspecific_i	1.30683368
52	MP0006072_abnormal_retinal_apoptosis	1.28174247
53	MP0000534_abnormal_ureter_morphology	1.26005463
54	MP0002234_abnormal_pharynx_morphology	1.22470435
55	MP0003646_muscle_fatigue	1.22385653
56	MP0003861_abnormal_nervous_system	1.20667919
57	MP0005187_abnormal_penis_morphology	1.16633651
58	MP0001919_abnormal_reproductive_system	1.13783785
59	MP0001486_abnormal_startle_reflex	1.11730689
60	MP0002152_abnormal_brain_morphology	1.11320126
61	MP0003115_abnormal_respiratory_system	1.10891519
62	MP0001970_abnormal_pain_threshold	1.08833729
63	MP0002064_seizures	1.08589030
64	MP0002067_abnormal_sensory_capabilities	1.07541250
65	MP0000026_abnormal_inner_ear	1.07042959
66	MP0005195_abnormal_posterior_eye	1.04620079
67	MP0003119_abnormal_digestive_system	1.03095056
68	MP0000372_irregular_coat_pigmentation	1.02725829
69	MP0001286_abnormal_eye_development	1.02535268
70	MP0002733_abnormal_thermal_nociception	1.01895570
71	MP0002938_white_spotting	1.00090193
72	MP0002837_dystrophic_cardiac_calcinosis	0.98130522
73	MP0005551_abnormal_eye_electrophysiolog	0.98023205
74	MP0005391_vision/eye_phenotype	0.94185316
75	MP0000569_abnormal_digit_pigmentation	0.93419933
76	MP0002233_abnormal_nose_morphology	0.92611774
77	MP0005386_behavior/neurological_phenoty	0.92609561
78	MP0004924_abnormal_behavior	0.92609561
79	MP0005646_abnormal_pituitary_gland	0.91248360
80	MP0001664_abnormal_digestion	0.83457513
81	MP0001188_hyperpigmentation	0.83385815
82	MP0003385_abnormal_body_wall	0.82584318
83	MP0002081_perinatal_lethality	0.82298086
84	MP0003942_abnormal_urinary_system	0.82275987
85	MP0001963_abnormal_hearing_physiology	0.80775387
86	MP0003935_abnormal_craniofacial_develop	0.80612416
87	MP0001501_abnormal_sleep_pattern	0.79542354
88	MP0000383_abnormal_hair_follicle	0.77321887
89	MP0005389_reproductive_system_phenotype	0.76781883
90	MP0002066_abnormal_motor_capabilities/c	0.75342879
91	MP0005379_endocrine/exocrine_gland_phen	0.73306772
92	MP0002697_abnormal_eye_size	0.73126432
93	MP0002928_abnormal_bile_duct	0.73124386
94	MP0010368_abnormal_lymphatic_system	0.72441856
95	MP0002109_abnormal_limb_morphology	0.71446789
96	MP0000467_abnormal_esophagus_morphology	0.71214552
97	MP0002210_abnormal_sex_determination	0.70872831
98	MP0003329_amyloid_beta_deposits	0.70491663
99	MP0008058_abnormal_DNA_repair	0.70178805
100	MP0003755_abnormal_palate_morphology	0.70157079

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retinal dysplasia (HP:0007973)	4.20249730
2	Broad-based gait (HP:0002136)	4.17525698
3	Adactyly (HP:0009776)	3.87513439
4	Hypoplastic pelvis (HP:0008839)	3.64619230
5	Lissencephaly (HP:0001339)	3.48967649
6	Long foot (HP:0001833)	3.40984770
7	Polymicrogyria (HP:0002126)	3.34590731
8	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.24400166
9	Severe muscular hypotonia (HP:0006829)	3.09880540
10	Type II lissencephaly (HP:0007260)	3.06243652
11	Duplicated collecting system (HP:0000081)	3.04247984
12	Limb dystonia (HP:0002451)	3.03223437
13	Chronic hepatic failure (HP:0100626)	2.98250113
14	Abnormality of the renal collecting system (HP:0004742)	2.96377208
15	Medial flaring of the eyebrow (HP:0010747)	2.95484305
16	Pachygyria (HP:0001302)	2.93518137
17	Drooling (HP:0002307)	2.90783674
18	Gait imbalance (HP:0002141)	2.90026228
19	Molar tooth sign on MRI (HP:0002419)	2.86334082
20	Abnormality of midbrain morphology (HP:0002418)	2.86334082
21	Cortical dysplasia (HP:0002539)	2.81765423
22	Nephronophthisis (HP:0000090)	2.78225270
23	Hyperventilation (HP:0002883)	2.75780728
24	Pancreatic fibrosis (HP:0100732)	2.74129515
25	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.73657372
26	Hypoplasia of the brainstem (HP:0002365)	2.73657372
27	Acute lymphatic leukemia (HP:0006721)	2.71468132
28	Nephrogenic diabetes insipidus (HP:0009806)	2.66566645
29	Excessive salivation (HP:0003781)	2.62796827
30	Congenital primary aphakia (HP:0007707)	2.62380920
31	Large for gestational age (HP:0001520)	2.61004808
32	Abnormality of the lower motor neuron (HP:0002366)	2.60160553
33	Amyotrophic lateral sclerosis (HP:0007354)	2.52136191
34	Polyphagia (HP:0002591)	2.48293063
35	Genital tract atresia (HP:0001827)	2.46879724
36	Focal seizures (HP:0007359)	2.36092834
37	Abnormality of the labia minora (HP:0012880)	2.35628807
38	True hermaphroditism (HP:0010459)	2.35370593
39	Chorioretinal coloboma (HP:0000567)	2.34661630
40	Focal motor seizures (HP:0011153)	2.34199091
41	Amblyopia (HP:0000646)	2.33197775
42	Pulmonary artery stenosis (HP:0004415)	2.33101242
43	Vaginal atresia (HP:0000148)	2.29385696
44	Abnormality of the renal medulla (HP:0100957)	2.26892241
45	Spastic tetraplegia (HP:0002510)	2.23497077
46	Inability to walk (HP:0002540)	2.21373892
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.18587814
48	Hypoplastic iliac wings (HP:0002866)	2.18378414
49	Hypoplastic nipples (HP:0002557)	2.18352732
50	Agitation (HP:0000713)	2.18294245
51	Pancreatic cysts (HP:0001737)	2.13115767
52	Anencephaly (HP:0002323)	2.12485626
53	Hemiparesis (HP:0001269)	2.09360768
54	Absent speech (HP:0001344)	2.07267579
55	Short tibia (HP:0005736)	2.05362858
56	Sclerocornea (HP:0000647)	2.05257138
57	Cerebellar dysplasia (HP:0007033)	2.03638168
58	Genetic anticipation (HP:0003743)	2.03040283
59	Febrile seizures (HP:0002373)	2.00362852
60	Specific learning disability (HP:0001328)	2.00087772
61	Postaxial hand polydactyly (HP:0001162)	1.94849699
62	Decreased testicular size (HP:0008734)	1.94767701
63	Protruding tongue (HP:0010808)	1.93777449
64	Decreased muscle mass (HP:0003199)	1.92209319
65	Short philtrum (HP:0000322)	1.92112335
66	Optic nerve hypoplasia (HP:0000609)	1.92028803
67	Brushfield spots (HP:0001088)	1.91554949
68	Micropenis (HP:0000054)	1.90280480
69	Occipital encephalocele (HP:0002085)	1.88550991
70	Hypoplasia of the corpus callosum (HP:0002079)	1.85370722
71	Anterior segment dysgenesis (HP:0007700)	1.85121452
72	Esotropia (HP:0000565)	1.84543068
73	Decreased lacrimation (HP:0000633)	1.84472917
74	Progressive inability to walk (HP:0002505)	1.84230120
75	Narrow forehead (HP:0000341)	1.82810563
76	Hip dysplasia (HP:0001385)	1.82767208
77	Urinary urgency (HP:0000012)	1.80952486
78	Exotropia (HP:0000577)	1.79469266
79	Progressive cerebellar ataxia (HP:0002073)	1.76154752
80	Thyroid-stimulating hormone excess (HP:0002925)	1.76140933
81	Rimmed vacuoles (HP:0003805)	1.75655509
82	Widely spaced teeth (HP:0000687)	1.75405297
83	Postaxial foot polydactyly (HP:0001830)	1.73832591
84	Wrist flexion contracture (HP:0001239)	1.72960915
85	Renal hypoplasia (HP:0000089)	1.71818814
86	Peripheral hypomyelination (HP:0007182)	1.70963778
87	Meningocele (HP:0002435)	1.70264885
88	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.70027156
89	Gaze-evoked nystagmus (HP:0000640)	1.69766177
90	Dialeptic seizures (HP:0011146)	1.68924478
91	Steppage gait (HP:0003376)	1.68264876
92	Renal dysplasia (HP:0000110)	1.67767776
93	Preaxial hand polydactyly (HP:0001177)	1.67194599
94	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.67106136
95	Fibular aplasia (HP:0002990)	1.66709573
96	Hypoplasia of the pons (HP:0012110)	1.66388558
97	Intestinal atresia (HP:0011100)	1.65335606
98	Scrotal hypoplasia (HP:0000046)	1.64055305
99	Poor coordination (HP:0002370)	1.63903250
100	Failure to thrive in infancy (HP:0001531)	1.63067282

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK2	7.88764642
2	MKNK1	4.67959183
3	TAOK1	4.05941880
4	CASK	3.38703164
5	MARK1	3.25124025
6	TAOK2	3.10652509
7	MAP2K7	2.72336311
8	MAP4K2	2.42486216
9	MAP3K4	2.38052303
10	MAP3K11	2.24205097
11	BCR	2.07415131
12	DYRK2	1.75276690
13	DYRK1A	1.68178770
14	MAP3K3	1.65462799
15	WNK3	1.64807429
16	NTRK2	1.61448416
17	CSNK1G2	1.59294483
18	MAPK13	1.50266795
19	TRIM28	1.44545565
20	SRPK1	1.39671590
21	MAP2K3	1.34826384
22	CSNK1G3	1.34363489
23	FRK	1.31410636
24	PINK1	1.26715466
25	EPHA4	1.24154197
26	SIK2	1.21304460
27	ADRBK2	1.20003294
28	CSNK1G1	1.18292917
29	ABL2	1.16697018
30	DYRK3	1.10465498
31	CSNK1A1L	1.10003349
32	ZAK	1.06298667
33	BCKDK	1.01829647
34	PAK3	1.00017922
35	TIE1	0.98900661
36	MAP3K5	0.89511438
37	PHKG1	0.86316582
38	PHKG2	0.86316582
39	NUAK1	0.82667799
40	NTRK1	0.78875957
41	PNCK	0.76904526
42	TAF1	0.75893016
43	PRKCG	0.75657982
44	EPHB2	0.73806307
45	GRK1	0.72434844
46	MINK1	0.69701689
47	NTRK3	0.68589253
48	LIMK1	0.66161653
49	TNIK	0.66142420
50	LMTK2	0.64910697
51	CHEK2	0.64310319
52	CDK19	0.61413261
53	MAP2K4	0.59556245
54	PKN1	0.58437016
55	DYRK1B	0.57014565
56	JAK3	0.56485966
57	CAMK1G	0.54693118
58	EPHA3	0.51727950
59	PIM2	0.50659306
60	PRKCE	0.46446275
61	PLK4	0.45163947
62	STK11	0.42146318
63	CDK5	0.41391187
64	CAMK1D	0.40987764
65	VRK1	0.37988092
66	PRKAA1	0.36561274
67	CSNK1A1	0.36403255
68	WNK4	0.35544613
69	OBSCN	0.34351318
70	SGK223	0.33558923
71	SGK494	0.33558923
72	UHMK1	0.32834066
73	BMPR1B	0.32489261
74	MAPK15	0.31086454
75	ERBB3	0.31024815
76	TLK1	0.30085762
77	CCNB1	0.28881620
78	INSRR	0.28685354
79	TESK2	0.28667822
80	ACVR1B	0.28635470
81	PAK6	0.28607152
82	PLK1	0.28185464
83	MAP3K10	0.28039022
84	RPS6KA5	0.26765516
85	CAMK4	0.26183244
86	RAF1	0.25790034
87	DAPK2	0.25215793
88	PRKCQ	0.24952729
89	BRD4	0.24735755
90	CDK14	0.23779512
91	CAMK2A	0.22611468
92	CAMKK2	0.21852605
93	STK38L	0.21617749
94	PRKD2	0.21537130
95	PRKD3	0.20478630
96	TYRO3	0.20381364
97	PRKCZ	0.20274291
98	CSNK1D	0.20131443
99	PRKACA	0.19484609
100	RPS6KA4	0.19385801

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.88631292
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.48903222
3	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	3.01516406
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.94829571
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.53355273
6	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.50949700
7	Taste transduction_Homo sapiens_hsa04742	2.49638599
8	RNA polymerase_Homo sapiens_hsa03020	2.36904362
9	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.00487825
10	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.99541786
11	Butanoate metabolism_Homo sapiens_hsa00650	1.93331830
12	Basal transcription factors_Homo sapiens_hsa03022	1.92680172
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.91567447
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90885667
15	GABAergic synapse_Homo sapiens_hsa04727	1.88538346
16	Phototransduction_Homo sapiens_hsa04744	1.83831883
17	Axon guidance_Homo sapiens_hsa04360	1.80649447
18	Morphine addiction_Homo sapiens_hsa05032	1.76453972
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.71322107
20	Lysine degradation_Homo sapiens_hsa00310	1.59784089
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.51691504
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.45824369
23	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.43928930
24	Fatty acid elongation_Homo sapiens_hsa00062	1.40441562
25	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.38553116
26	Basal cell carcinoma_Homo sapiens_hsa05217	1.37955548
27	Dopaminergic synapse_Homo sapiens_hsa04728	1.35864913
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.31338580
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.28779200
30	Cocaine addiction_Homo sapiens_hsa05030	1.26236140
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.26038532
32	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.23931720
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.22439389
34	Circadian entrainment_Homo sapiens_hsa04713	1.19310119
35	Protein export_Homo sapiens_hsa03060	1.11085263
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10013923
37	Base excision repair_Homo sapiens_hsa03410	1.09908107
38	Cholinergic synapse_Homo sapiens_hsa04725	1.03117214
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99860103
40	Serotonergic synapse_Homo sapiens_hsa04726	0.99032654
41	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.95923518
42	Regulation of autophagy_Homo sapiens_hsa04140	0.95154338
43	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92083239
44	Circadian rhythm_Homo sapiens_hsa04710	0.91336117
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88689768
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.88593067
47	Hippo signaling pathway_Homo sapiens_hsa04390	0.88188408
48	Alcoholism_Homo sapiens_hsa05034	0.86988813
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84737154
50	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.83035348
51	Propanoate metabolism_Homo sapiens_hsa00640	0.79812699
52	Long-term depression_Homo sapiens_hsa04730	0.78807403
53	Type II diabetes mellitus_Homo sapiens_hsa04930	0.78039284
54	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.77419253
55	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.75324975
56	RNA transport_Homo sapiens_hsa03013	0.73574694
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.73143045
58	Gap junction_Homo sapiens_hsa04540	0.73133385
59	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.72704144
60	RNA degradation_Homo sapiens_hsa03018	0.72373493
61	Parkinsons disease_Homo sapiens_hsa05012	0.69412700
62	Olfactory transduction_Homo sapiens_hsa04740	0.68667534
63	Insulin secretion_Homo sapiens_hsa04911	0.66653922
64	Huntingtons disease_Homo sapiens_hsa05016	0.63268834
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62955588
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62720971
67	Wnt signaling pathway_Homo sapiens_hsa04310	0.62131683
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62071153
69	Peroxisome_Homo sapiens_hsa04146	0.61813953
70	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.60363321
71	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.57453790
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.57056261
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.56562877
74	AMPK signaling pathway_Homo sapiens_hsa04152	0.55862492
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.55223349
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.54603754
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.53822765
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53216607
79	Tryptophan metabolism_Homo sapiens_hsa00380	0.52445053
80	Purine metabolism_Homo sapiens_hsa00230	0.52428753
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51490747
82	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48822232
83	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47912258
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.47875027
85	Salivary secretion_Homo sapiens_hsa04970	0.47608085
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.46320668
87	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45748492
88	ABC transporters_Homo sapiens_hsa02010	0.45536821
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44653316
90	Amphetamine addiction_Homo sapiens_hsa05031	0.44454285
91	Oocyte meiosis_Homo sapiens_hsa04114	0.43527608
92	Ras signaling pathway_Homo sapiens_hsa04014	0.43491339
93	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43151618
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42698120
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.41396057
96	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.41223175
97	Notch signaling pathway_Homo sapiens_hsa04330	0.41073319
98	MicroRNAs in cancer_Homo sapiens_hsa05206	0.40188080
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35389799
100	Rap1 signaling pathway_Homo sapiens_hsa04015	0.34934517

ZNF71

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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