ZNF710

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.05960749
2modulation by symbiont of host defense response (GO:0052031)4.92822833
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.92822833
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.92822833
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.92822833
6modulation by symbiont of host immune response (GO:0052553)4.92822833
7positive regulation by symbiont of host defense response (GO:0052509)4.92822833
8positive regulation of gamma-delta T cell activation (GO:0046645)4.80383450
9macrophage activation involved in immune response (GO:0002281)4.55093445
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.49573815
11negative regulation of cell killing (GO:0031342)4.49573815
12negative regulation of interleukin-12 production (GO:0032695)4.23933884
13detection of other organism (GO:0098543)4.18333883
14negative regulation of erythrocyte differentiation (GO:0045647)4.14045107
15detection of bacterium (GO:0016045)3.97080049
16response to muramyl dipeptide (GO:0032495)3.90821628
17neutrophil activation involved in immune response (GO:0002283)3.89490153
18detection of molecule of bacterial origin (GO:0032490)3.70497236
19regulation of gamma-delta T cell activation (GO:0046643)3.67988874
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67662984
21germinal center formation (GO:0002467)3.66628417
22detection of external biotic stimulus (GO:0098581)3.62957287
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57099848
24antigen processing and presentation of endogenous antigen (GO:0019883)3.57057085
25regulation of interferon-beta biosynthetic process (GO:0045357)3.52807665
26cellular extravasation (GO:0045123)3.49606368
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.46517423
28immunoglobulin mediated immune response (GO:0016064)3.43717428
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.43328806
30regulation of mast cell degranulation (GO:0043304)3.32313593
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31619806
32response to host immune response (GO:0052572)3.28122479
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.28122479
34regulation of leukocyte degranulation (GO:0043300)3.25596744
35detection of biotic stimulus (GO:0009595)3.24918811
36regulation of myeloid leukocyte mediated immunity (GO:0002886)3.21319068
37leukocyte aggregation (GO:0070486)3.14655372
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12646685
39response to host (GO:0075136)3.12646685
40response to host defenses (GO:0052200)3.12646685
41macrophage activation (GO:0042116)3.12271087
42regulation of B cell receptor signaling pathway (GO:0050855)3.09224717
43regulation of T-helper 2 cell differentiation (GO:0045628)3.04733359
44positive regulation of cellular amide metabolic process (GO:0034250)3.02598785
45negative regulation of toll-like receptor signaling pathway (GO:0034122)3.00700377
46respiratory burst (GO:0045730)2.99098387
47regulation of mast cell activation involved in immune response (GO:0033006)2.96135887
48regulation of gamma-delta T cell differentiation (GO:0045586)2.94948113
49type I interferon signaling pathway (GO:0060337)2.94430709
50cellular response to type I interferon (GO:0071357)2.94430709
51NIK/NF-kappaB signaling (GO:0038061)2.94419753
52response to type I interferon (GO:0034340)2.93727185
53regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92598803
54granulocyte activation (GO:0036230)2.91044515
55mannose metabolic process (GO:0006013)2.89678702
56myeloid cell activation involved in immune response (GO:0002275)2.89534437
57neutrophil activation (GO:0042119)2.86762517
58regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84963218
59negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.81409724
60interferon-gamma-mediated signaling pathway (GO:0060333)2.80855908
61B cell receptor signaling pathway (GO:0050853)2.79845521
62negative regulation of cytokine production involved in immune response (GO:0002719)2.77117815
63microglial cell activation (GO:0001774)2.77087217
64defense response to protozoan (GO:0042832)2.76736252
65protein localization to endosome (GO:0036010)2.75590672
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73370846
67T-helper 1 type immune response (GO:0042088)2.72301979
68positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71948817
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71918738
70epithelial cell differentiation involved in prostate gland development (GO:0060742)2.71516466
71negative regulation of lymphocyte mediated immunity (GO:0002707)2.71328271
72negative regulation of leukocyte mediated immunity (GO:0002704)2.70754967
73negative regulation of T cell mediated immunity (GO:0002710)2.69801614
74positive regulation of interferon-alpha production (GO:0032727)2.67602515
75regulation of necroptotic process (GO:0060544)2.67592747
76regulation of regulated secretory pathway (GO:1903305)2.66787846
77positive regulation of mast cell activation (GO:0033005)2.65254822
78regulation of interferon-alpha production (GO:0032647)2.64761312
79positive regulation of Cdc42 GTPase activity (GO:0043089)2.64715290
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63884189
81response to protozoan (GO:0001562)2.63761666
82production of molecular mediator involved in inflammatory response (GO:0002532)2.63006568
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62500889
84positive regulation of type 2 immune response (GO:0002830)2.60019005
85positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.57061943
86regulation of macrophage cytokine production (GO:0010935)2.51889210
87regulation of T cell tolerance induction (GO:0002664)2.51737837
88response to laminar fluid shear stress (GO:0034616)2.51723492
89positive thymic T cell selection (GO:0045059)2.51227591
90myeloid dendritic cell differentiation (GO:0043011)2.50087789
91regulation of tolerance induction (GO:0002643)2.49983221
92regulation of mast cell activation (GO:0033003)2.49675224
93positive regulation of B cell differentiation (GO:0045579)2.48080725
94modulation by symbiont of host cellular process (GO:0044068)2.47635014
95regulation of toll-like receptor signaling pathway (GO:0034121)2.46422397
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.46122516
97positive regulation of mast cell degranulation (GO:0043306)2.46122516
98regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45362202
99regulation of antigen processing and presentation (GO:0002577)2.44762063
100negative regulation of interleukin-6 production (GO:0032715)2.43629168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.95124144
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.32628454
3VDR_21846776_ChIP-Seq_THP-1_Human3.12467089
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74271609
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.73236453
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.73008118
7MYC_22102868_ChIP-Seq_BL_Human2.64066119
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60748398
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.59953153
10VDR_24763502_ChIP-Seq_THP-1_Human2.48663462
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46603793
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.46061704
13TCF7_22412390_ChIP-Seq_EML_Mouse2.39164773
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.38521971
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38038614
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.34859516
17LXR_22292898_ChIP-Seq_THP-1_Human2.32140633
18KDM2B_26808549_Chip-Seq_DND41_Human2.26571998
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26504961
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26241061
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22610012
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.17248979
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08543073
24* SPI1_23127762_ChIP-Seq_K562_Human2.06237894
25MAF_26560356_Chip-Seq_TH1_Human1.99537711
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99428602
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96034376
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95993594
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95841148
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.83244900
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82682565
32SCL_19346495_ChIP-Seq_HPC-7_Human1.79763753
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78575685
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.74712431
35UTX_26944678_Chip-Seq_JUKART_Human1.70203661
36RACK7_27058665_Chip-Seq_MCF-7_Human1.65380364
37KDM2B_26808549_Chip-Seq_K562_Human1.65256913
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60510438
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60214999
40* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59909388
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59471288
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58848848
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.58527230
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.57844162
45SPI1_23547873_ChIP-Seq_NB4_Human1.56819626
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55367411
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54693181
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51290955
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.50856840
50MAF_26560356_Chip-Seq_TH2_Human1.50279820
51RUNX_20019798_ChIP-Seq_JUKART_Human1.49596372
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48455687
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46185057
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38281332
55VDR_24787735_ChIP-Seq_THP-1_Human1.35940508
56* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35267491
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32983861
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32975160
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31359609
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30528861
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29172214
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25656865
63* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25339978
64* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22690791
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20884641
66* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20658895
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20233072
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17606992
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16910854
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16008873
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15482765
72GATA1_19941826_ChIP-Seq_K562_Human1.14544269
73MYB_26560356_Chip-Seq_TH2_Human1.13990373
74MYB_26560356_Chip-Seq_TH1_Human1.13327264
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12977291
76* SA1_27219007_Chip-Seq_ERYTHROID_Human1.12282996
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10978645
78SMC4_20622854_ChIP-Seq_HELA_Human1.10442370
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09196026
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08390575
81PU_27001747_Chip-Seq_BMDM_Mouse1.07978956
82NCOR1_26117541_ChIP-Seq_K562_Human1.06484737
83* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06152906
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05810325
85BCOR_27268052_Chip-Seq_Bcells_Human1.05723940
86P68_20966046_ChIP-Seq_HELA_Human1.04698141
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02672508
88* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99290732
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98457921
90BCL6_27268052_Chip-Seq_Bcells_Human0.97602216
91RUNX1_27514584_Chip-Seq_MCF-7_Human0.97365337
92* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97217183
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94884922
94TBX20_22328084_ChIP-Seq_HEART_Mouse0.94557975
95TBX20_22080862_ChIP-Seq_HEART_Mouse0.94557975
96GATA1_22025678_ChIP-Seq_K562_Human0.94449050
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94317706
98CREB1_26743006_Chip-Seq_LNCaP_Human0.93781423
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93750952
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.92020906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.47103750
2MP0003436_decreased_susceptibility_to3.72141757
3MP0003724_increased_susceptibility_to3.17159736
4MP0005451_abnormal_body_composition3.06603367
5MP0003300_gastrointestinal_ulcer2.87215598
6MP0005058_abnormal_lysosome_morphology2.77643984
7MP0001835_abnormal_antigen_presentation2.69753414
8MP0002419_abnormal_innate_immunity2.67490814
9MP0004510_myositis2.52075372
10MP0005387_immune_system_phenotype2.44363113
11MP0001790_abnormal_immune_system2.44363113
12MP0005025_abnormal_response_to2.44217990
13MP0005000_abnormal_immune_tolerance2.33935214
14MP0003705_abnormal_hypodermis_morpholog2.32878504
15MP0009278_abnormal_bone_marrow2.32187405
16MP0006082_CNS_inflammation2.31447420
17MP0003191_abnormal_cellular_cholesterol2.30188951
18MP0003172_abnormal_lysosome_physiology2.29860647
19MP0000685_abnormal_immune_system2.27706811
20MP0009785_altered_susceptibility_to2.26837713
21MP0005671_abnormal_response_to2.16313096
22MP0001800_abnormal_humoral_immune2.13189002
23MP0002148_abnormal_hypersensitivity_rea2.05581907
24MP0002452_abnormal_antigen_presenting2.03078844
25MP0002723_abnormal_immune_serum2.02156828
26MP0008260_abnormal_autophagy1.98434052
27MP0001533_abnormal_skeleton_physiology1.93011397
28MP0002420_abnormal_adaptive_immunity1.90099046
29MP0001819_abnormal_immune_cell1.89668483
30MP0004947_skin_inflammation1.89335270
31MP0009840_abnormal_foam_cell1.86519488
32MP0003828_pulmonary_edema1.85554577
33MP0005464_abnormal_platelet_physiology1.70879002
34MP0003075_altered_response_to1.66685909
35MP0002998_abnormal_bone_remodeling1.66075583
36MP0003763_abnormal_thymus_physiology1.58849148
37MP0010155_abnormal_intestine_physiology1.56000101
38MP0002405_respiratory_system_inflammati1.54693587
39MP0000858_altered_metastatic_potential1.49907560
40MP0003453_abnormal_keratinocyte_physiol1.44810466
41MP0005076_abnormal_cell_differentiation1.44262384
42MP0001845_abnormal_inflammatory_respons1.42157457
43MP0009333_abnormal_splenocyte_physiolog1.40133953
44MP0000716_abnormal_immune_system1.39847389
45MP0001545_abnormal_hematopoietic_system1.39325593
46MP0005397_hematopoietic_system_phenotyp1.39325593
47MP0002398_abnormal_bone_marrow1.33314329
48MP0003690_abnormal_glial_cell1.31500667
49MP0001849_ear_inflammation1.30350186
50MP0003091_abnormal_cell_migration1.30222366
51MP0002332_abnormal_exercise_endurance1.30147796
52MP0008004_abnormal_stomach_pH1.28639147
53MP0000343_altered_response_to1.27372032
54MP0008469_abnormal_protein_level1.25276576
55MP0005166_decreased_susceptibility_to1.20789278
56MP0000604_amyloidosis1.16939070
57MP0003183_abnormal_peptide_metabolism1.16678321
58MP0009764_decreased_sensitivity_to1.16068293
59MP0004858_abnormal_nervous_system1.13904975
60MP0005167_abnormal_blood-brain_barrier1.13094978
61MP0005409_darkened_coat_color1.12660429
62MP0002429_abnormal_blood_cell1.09261496
63MP0005310_abnormal_salivary_gland1.07001114
64MP0002722_abnormal_immune_system1.06531809
65MP0003566_abnormal_cell_adhesion1.05895966
66MP0003646_muscle_fatigue1.04700244
67MP0001853_heart_inflammation1.04125491
68MP0004130_abnormal_muscle_cell1.03998460
69MP0004381_abnormal_hair_follicle1.02441097
70MP0000689_abnormal_spleen_morphology1.02091435
71MP0000747_muscle_weakness1.00598300
72MP0001851_eye_inflammation0.98554184
73MP0000465_gastrointestinal_hemorrhage0.96858650
74MP0003448_altered_tumor_morphology0.96256823
75MP0004808_abnormal_hematopoietic_stem0.92951115
76MP0004233_abnormal_muscle_weight0.91593572
77MP0000751_myopathy0.88776601
78MP0000703_abnormal_thymus_morphology0.86463139
79MP0004185_abnormal_adipocyte_glucose0.86099209
80MP0004883_abnormal_blood_vessel0.85803818
81MP0005666_abnormal_adipose_tissue0.83885969
82MP0005390_skeleton_phenotype0.83027766
83MP0002396_abnormal_hematopoietic_system0.82937056
84MP0003656_abnormal_erythrocyte_physiolo0.82445578
85MP0003221_abnormal_cardiomyocyte_apopto0.80253676
86MP0004036_abnormal_muscle_relaxation0.78794849
87MP0003045_fibrosis0.78696353
88MP0000750_abnormal_muscle_regeneration0.78650773
89MP0008874_decreased_physiological_sensi0.77636088
90MP0003329_amyloid_beta_deposits0.77210401
91MP0003279_aneurysm0.77132645
92MP0002132_abnormal_respiratory_system0.77085807
93MP0003866_abnormal_defecation0.76482182
94MP0002254_reproductive_system_inflammat0.76325751
95MP0004087_abnormal_muscle_fiber0.75964025
96MP0000249_abnormal_blood_vessel0.74289118
97MP0005164_abnormal_response_to0.73789540
98MP0010234_abnormal_vibrissa_follicle0.72707255
99MP0000767_abnormal_smooth_muscle0.70796524
100MP0010630_abnormal_cardiac_muscle0.70531761

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.21052759
2Recurrent bacterial skin infections (HP:0005406)4.48160437
3Recurrent abscess formation (HP:0002722)4.40242288
4Abnormality of macrophages (HP:0004311)4.35077969
5Orchitis (HP:0100796)3.64253239
6Myositis (HP:0100614)3.61755158
7Recurrent gram-negative bacterial infections (HP:0005420)3.58300218
8Abnormality of liposaccharide metabolism (HP:0010968)3.42203567
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.42203567
10Abnormality of glycolipid metabolism (HP:0010969)3.42203567
11Optic neuritis (HP:0100653)3.27514926
12Retrobulbar optic neuritis (HP:0100654)3.27514926
13Mediastinal lymphadenopathy (HP:0100721)3.23889476
14Spontaneous hematomas (HP:0007420)3.14966473
15Increased cerebral lipofuscin (HP:0011813)3.07139611
16Increased IgE level (HP:0003212)2.95074395
17Centrally nucleated skeletal muscle fibers (HP:0003687)2.94128696
18Chronic obstructive pulmonary disease (HP:0006510)2.86193370
19Obstructive lung disease (HP:0006536)2.86193370
20Gingivitis (HP:0000230)2.85673166
21Recurrent fungal infections (HP:0002841)2.82987560
22Recurrent skin infections (HP:0001581)2.81939887
23Cellulitis (HP:0100658)2.80118191
24Exercise-induced myalgia (HP:0003738)2.75112486
25Meningitis (HP:0001287)2.71036982
26Systemic lupus erythematosus (HP:0002725)2.68598805
27Dysostosis multiplex (HP:0000943)2.65135811
28Loss of speech (HP:0002371)2.62614423
29Colitis (HP:0002583)2.61626056
30Asymmetric septal hypertrophy (HP:0001670)2.60968584
31Amyloidosis (HP:0011034)2.52477201
32Gastrointestinal infarctions (HP:0005244)2.48825553
33Chronic mucocutaneous candidiasis (HP:0002728)2.43852984
34Recurrent cutaneous fungal infections (HP:0011370)2.43852984
35Stomatitis (HP:0010280)2.43648303
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.43013617
37Increased connective tissue (HP:0009025)2.39980347
38Muscle fiber inclusion bodies (HP:0100299)2.36149311
39Keratoconjunctivitis sicca (HP:0001097)2.35491122
40Distal lower limb muscle weakness (HP:0009053)2.34749981
41Recurrent viral infections (HP:0004429)2.32350603
42Vasculitis (HP:0002633)2.32179011
43Difficulty running (HP:0009046)2.30602728
44Abnormality of skeletal muscle fiber size (HP:0012084)2.29903766
45Gastrointestinal inflammation (HP:0004386)2.28951083
46Nemaline bodies (HP:0003798)2.28948001
47Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.28897291
48Urticaria (HP:0001025)2.27953570
49Elevated erythrocyte sedimentation rate (HP:0003565)2.27166699
50Inflammation of the large intestine (HP:0002037)2.24267750
51Vacuolated lymphocytes (HP:0001922)2.21290989
52Chest pain (HP:0100749)2.20844270
53Axonal loss (HP:0003447)2.20611441
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.18371717
55Increased variability in muscle fiber diameter (HP:0003557)2.17381160
56Disinhibition (HP:0000734)2.17236373
57Muscle fiber splitting (HP:0003555)2.15420326
58Neuronal loss in central nervous system (HP:0002529)2.10330446
59Distal lower limb amyotrophy (HP:0008944)2.10296976
60Type 1 muscle fiber predominance (HP:0003803)2.09779705
61Hemoptysis (HP:0002105)2.07752457
62Obstructive sleep apnea (HP:0002870)2.07614660
63Keratoconjunctivitis (HP:0001096)2.04893345
64Arterial thrombosis (HP:0004420)2.04102041
65Pulmonary infiltrates (HP:0002113)2.03146438
66Interstitial pulmonary disease (HP:0006530)2.01879300
67Purpura (HP:0000979)2.01830402
68Myopathic facies (HP:0002058)2.01366710
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01318971
70Abnormality of polysaccharide metabolism (HP:0011012)2.01318971
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01318971
72Encephalitis (HP:0002383)2.00233974
73Cerebral aneurysm (HP:0004944)1.99863990
74Increased serum ferritin (HP:0003281)1.98052582
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95959189
76Mucopolysacchariduria (HP:0008155)1.94498458
77Urinary glycosaminoglycan excretion (HP:0003541)1.94498458
78Hyporeflexia of lower limbs (HP:0002600)1.93349612
79Prolonged bleeding time (HP:0003010)1.93249465
80Segmental peripheral demyelination/remyelination (HP:0003481)1.92939343
81Abnormality of the endocardium (HP:0004306)1.92517359
82Epistaxis (HP:0000421)1.92319239
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91866042
84Neurofibrillary tangles (HP:0002185)1.91394066
85Pustule (HP:0200039)1.91216368
86Gastrointestinal stroma tumor (HP:0100723)1.87365494
87Restrictive lung disease (HP:0002091)1.86668621
88EMG: myopathic abnormalities (HP:0003458)1.86585824
89Osteomyelitis (HP:0002754)1.84046905
90Thoracic kyphosis (HP:0002942)1.83333732
91Thin bony cortex (HP:0002753)1.82864932
92Pulmonary embolism (HP:0002204)1.82742186
93Abnormality of the fingertips (HP:0001211)1.82222962
94Bulbar palsy (HP:0001283)1.80657310
95Autoimmune thrombocytopenia (HP:0001973)1.78761915
96Slow saccadic eye movements (HP:0000514)1.78241074
97Polygenic inheritance (HP:0010982)1.77885035
98Malnutrition (HP:0004395)1.75387573
99Hematochezia (HP:0002573)1.75099318
100Upper motor neuron abnormality (HP:0002127)1.74986773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.27682386
2ERN13.13002282
3PRPF4B3.10494428
4TRIB32.98756241
5MAP2K32.63686253
6MAP4K12.49174501
7BLK2.42496538
8TYK22.25361884
9IRAK32.17891333
10IRAK42.02540106
11RIPK11.97369644
12CSK1.93569627
13TTN1.81814036
14SIK11.78496710
15MAP3K131.77902323
16MAP3K141.77290921
17TAOK11.70783726
18SMG11.64384529
19ZAP701.63567898
20MAP3K31.62156832
21TBK11.58762412
22FGR1.51639459
23EPHB11.50296541
24ICK1.46563436
25FES1.44319294
26MAP3K111.43684533
27CDK121.43426404
28CDC42BPA1.39414727
29JAK31.37750459
30MAP3K11.37055032
31TNK21.36123313
32MARK21.26941120
33FGFR41.26922023
34KSR21.24695847
35TAOK21.22110959
36TGFBR21.17824274
37MAP3K101.17342620
38MATK1.15879807
39EEF2K1.14936493
40OBSCN1.14544119
41IRAK21.14251985
42IKBKE1.13761927
43HCK1.12626009
44BTK1.12209120
45JAK11.05639710
46CSF1R1.03021602
47MAPK121.01540532
48PKN20.99655826
49SYK0.94158668
50PDPK10.92198600
51MOS0.91458497
52JAK20.90875639
53PTK60.89307705
54SIK20.89121767
55SIK30.85600810
56GRK60.83543140
57PRKD20.80092428
58PDK10.79279958
59MAP3K70.78151663
60MAPK70.75809753
61RPS6KA20.75473410
62RPS6KC10.74966470
63RPS6KL10.74966470
64IKBKB0.74429036
65LYN0.73865673
66MAP3K60.73398125
67SGK30.72385025
68CAMK1D0.71585094
69MARK30.71531953
70GRK70.66917962
71ARAF0.64275920
72DDR20.64127552
73LCK0.64091304
74HIPK20.63986706
75NME20.62868069
76IRAK10.61837771
77FGFR30.61425321
78DYRK1B0.58077048
79RET0.56287329
80RPS6KA60.55431647
81STK100.54986019
82YES10.54221045
83LRRK20.51203258
84KIT0.50613239
85MTOR0.49780855
86PDGFRA0.49074510
87TYRO30.49003161
88TESK20.48601107
89ITK0.47423788
90CHUK0.46446903
91BMX0.42264129
92PRKG20.42211543
93PDGFRB0.41756038
94MAP2K60.40970208
95MAPK40.40714785
96CDK40.40410634
97PIK3CG0.40032267
98MAP2K40.40001347
99MAP3K80.39493184
100FYN0.39465694

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.59825214
2Leishmaniasis_Homo sapiens_hsa051402.41423032
3Other glycan degradation_Homo sapiens_hsa005112.32319965
4Staphylococcus aureus infection_Homo sapiens_hsa051502.21816515
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11587281
6B cell receptor signaling pathway_Homo sapiens_hsa046622.10011279
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91550944
8Tuberculosis_Homo sapiens_hsa051521.89606882
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87487816
10Acute myeloid leukemia_Homo sapiens_hsa052211.79073235
11Graft-versus-host disease_Homo sapiens_hsa053321.56189643
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55906987
13Malaria_Homo sapiens_hsa051441.54271090
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.52834955
15Allograft rejection_Homo sapiens_hsa053301.51684086
16Toxoplasmosis_Homo sapiens_hsa051451.49885627
17TNF signaling pathway_Homo sapiens_hsa046681.47312444
18Influenza A_Homo sapiens_hsa051641.46619819
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40805938
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39402875
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39335683
22VEGF signaling pathway_Homo sapiens_hsa043701.37539828
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34676904
24Lysosome_Homo sapiens_hsa041421.34350681
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34117828
26Viral myocarditis_Homo sapiens_hsa054161.33774781
27Chronic myeloid leukemia_Homo sapiens_hsa052201.31583687
28Chemokine signaling pathway_Homo sapiens_hsa040621.30971475
29Notch signaling pathway_Homo sapiens_hsa043301.30374755
30Pertussis_Homo sapiens_hsa051331.29930504
31Non-small cell lung cancer_Homo sapiens_hsa052231.29025303
32Autoimmune thyroid disease_Homo sapiens_hsa053201.28819681
33T cell receptor signaling pathway_Homo sapiens_hsa046601.25953888
34Measles_Homo sapiens_hsa051621.25506598
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.21502231
36Legionellosis_Homo sapiens_hsa051341.21316451
37Hepatitis C_Homo sapiens_hsa051601.18835886
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16412428
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.15263748
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14315365
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.13850454
42Hepatitis B_Homo sapiens_hsa051611.13095865
43Pancreatic cancer_Homo sapiens_hsa052121.12202985
44Salmonella infection_Homo sapiens_hsa051321.12087377
45Antigen processing and presentation_Homo sapiens_hsa046121.11073229
46Phagosome_Homo sapiens_hsa041451.04666015
47Amoebiasis_Homo sapiens_hsa051461.02696684
48Renal cell carcinoma_Homo sapiens_hsa052111.02096778
49Herpes simplex infection_Homo sapiens_hsa051681.02040595
50Bladder cancer_Homo sapiens_hsa052190.99815282
51Hematopoietic cell lineage_Homo sapiens_hsa046400.99594709
52Platelet activation_Homo sapiens_hsa046110.97255080
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.96979699
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.96743777
55GnRH signaling pathway_Homo sapiens_hsa049120.96707994
56Rheumatoid arthritis_Homo sapiens_hsa053230.95992658
57Endometrial cancer_Homo sapiens_hsa052130.95883083
58Prolactin signaling pathway_Homo sapiens_hsa049170.95262776
59Asthma_Homo sapiens_hsa053100.94658380
60African trypanosomiasis_Homo sapiens_hsa051430.91517004
61Apoptosis_Homo sapiens_hsa042100.91098270
62Type I diabetes mellitus_Homo sapiens_hsa049400.90385019
63Shigellosis_Homo sapiens_hsa051310.87784673
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.85384222
65Primary immunodeficiency_Homo sapiens_hsa053400.85312560
66Prion diseases_Homo sapiens_hsa050200.84660928
67Insulin signaling pathway_Homo sapiens_hsa049100.84452454
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.83614969
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.82411904
70Insulin resistance_Homo sapiens_hsa049310.81517047
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78210686
72mTOR signaling pathway_Homo sapiens_hsa041500.77512921
73ErbB signaling pathway_Homo sapiens_hsa040120.73473629
74HIF-1 signaling pathway_Homo sapiens_hsa040660.70036958
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69490329
76Endocytosis_Homo sapiens_hsa041440.69414990
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68890257
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68122644
79Choline metabolism in cancer_Homo sapiens_hsa052310.68071156
80Estrogen signaling pathway_Homo sapiens_hsa049150.67961186
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67657432
82Glioma_Homo sapiens_hsa052140.65199488
83FoxO signaling pathway_Homo sapiens_hsa040680.64702936
84HTLV-I infection_Homo sapiens_hsa051660.58597871
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58219646
86Dorso-ventral axis formation_Homo sapiens_hsa043200.57728309
87Viral carcinogenesis_Homo sapiens_hsa052030.57470504
88Prostate cancer_Homo sapiens_hsa052150.56256271
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56067867
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.55972305
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55927195
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55720739
93Type II diabetes mellitus_Homo sapiens_hsa049300.55529237
94MAPK signaling pathway_Homo sapiens_hsa040100.55147260
95Colorectal cancer_Homo sapiens_hsa052100.54501414
96Inositol phosphate metabolism_Homo sapiens_hsa005620.53912174
97Epstein-Barr virus infection_Homo sapiens_hsa051690.52264576
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52072958
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50781708
100Rap1 signaling pathway_Homo sapiens_hsa040150.49971154

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