ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.80869802
2	fucose catabolic process (GO:0019317)	5.17056929
3	L-fucose metabolic process (GO:0042354)	5.17056929
4	L-fucose catabolic process (GO:0042355)	5.17056929
5	response to pheromone (GO:0019236)	4.08450467
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.77054304
7	indole-containing compound catabolic process (GO:0042436)	3.73228952
8	indolalkylamine catabolic process (GO:0046218)	3.73228952
9	tryptophan catabolic process (GO:0006569)	3.73228952
10	kynurenine metabolic process (GO:0070189)	3.56065731
11	negative regulation of telomere maintenance (GO:0032205)	3.55273020
12	indolalkylamine metabolic process (GO:0006586)	3.53130281
13	cellular ketone body metabolic process (GO:0046950)	3.53086279
14	DNA deamination (GO:0045006)	3.52731275
15	piRNA metabolic process (GO:0034587)	3.51486900
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.41810725
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.34621582
18	detection of light stimulus involved in visual perception (GO:0050908)	3.34621582
19	sulfation (GO:0051923)	3.33097377
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.30413370
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23677127
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23677127
23	NADH dehydrogenase complex assembly (GO:0010257)	3.23677127
24	platelet dense granule organization (GO:0060155)	3.20606226
25	protein-cofactor linkage (GO:0018065)	3.18225994
26	respiratory chain complex IV assembly (GO:0008535)	3.17686167
27	ketone body metabolic process (GO:1902224)	3.17640010
28	amine catabolic process (GO:0009310)	3.16275601
29	cellular biogenic amine catabolic process (GO:0042402)	3.16275601
30	protein complex biogenesis (GO:0070271)	3.14703468
31	negative regulation of mast cell activation (GO:0033004)	3.14183605
32	tryptophan metabolic process (GO:0006568)	3.12676263
33	reflex (GO:0060004)	3.12557378
34	epithelial cilium movement (GO:0003351)	3.09876057
35	retinal cone cell development (GO:0046549)	3.02274815
36	gamma-aminobutyric acid transport (GO:0015812)	3.01272199
37	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.01044027
38	axoneme assembly (GO:0035082)	3.01035183
39	rRNA catabolic process (GO:0016075)	2.98262294
40	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91648191
41	protein polyglutamylation (GO:0018095)	2.91134591
42	nonmotile primary cilium assembly (GO:0035058)	2.91016941
43	ubiquinone biosynthetic process (GO:0006744)	2.89815978
44	neuronal action potential (GO:0019228)	2.85589362
45	cilium morphogenesis (GO:0060271)	2.84964994
46	auditory receptor cell stereocilium organization (GO:0060088)	2.84297050
47	regulation of neurotransmitter uptake (GO:0051580)	2.83366711
48	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81995580
49	regulation of action potential (GO:0098900)	2.81176063
50	multicellular organism reproduction (GO:0032504)	2.80598852
51	protein localization to cilium (GO:0061512)	2.80336602
52	cytochrome complex assembly (GO:0017004)	2.79241235
53	kidney morphogenesis (GO:0060993)	2.79234016
54	DNA methylation involved in gamete generation (GO:0043046)	2.75492929
55	regulation of cilium movement (GO:0003352)	2.74131139
56	ubiquinone metabolic process (GO:0006743)	2.73814820
57	rhodopsin mediated signaling pathway (GO:0016056)	2.73510227
58	nephron tubule morphogenesis (GO:0072078)	2.73401660
59	nephron epithelium morphogenesis (GO:0072088)	2.73401660
60	indole-containing compound metabolic process (GO:0042430)	2.73341865
61	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.70116036
62	male meiosis (GO:0007140)	2.68799624
63	regulation of memory T cell differentiation (GO:0043380)	2.67514910
64	protein K11-linked deubiquitination (GO:0035871)	2.67426243
65	cornea development in camera-type eye (GO:0061303)	2.65058953
66	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.64822310
67	neural tube formation (GO:0001841)	2.64714968
68	male meiosis I (GO:0007141)	2.64249441
69	adaptation of signaling pathway (GO:0023058)	2.63843906
70	inner ear receptor stereocilium organization (GO:0060122)	2.63449180
71	synaptic transmission, cholinergic (GO:0007271)	2.60236020
72	replication fork processing (GO:0031297)	2.60129119
73	cilium organization (GO:0044782)	2.58045782
74	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.56355112
75	behavioral response to ethanol (GO:0048149)	2.55999534
76	fucosylation (GO:0036065)	2.54906261
77	alanine transport (GO:0032328)	2.54250890
78	photoreceptor cell maintenance (GO:0045494)	2.54186963
79	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.54050603
80	proline transport (GO:0015824)	2.53168481
81	cilium movement (GO:0003341)	2.52284276
82	primary amino compound metabolic process (GO:1901160)	2.51814136
83	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.51364512
84	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.51137804
85	dopamine transport (GO:0015872)	2.51107108
86	recombinational repair (GO:0000725)	2.49283761
87	mannosylation (GO:0097502)	2.49118727
88	cilium assembly (GO:0042384)	2.48915295
89	thyroid hormone metabolic process (GO:0042403)	2.47055674
90	photoreceptor cell development (GO:0042461)	2.46732568
91	positive regulation of defense response to virus by host (GO:0002230)	2.46258058
92	cellular response to ATP (GO:0071318)	2.45251136
93	DNA double-strand break processing (GO:0000729)	2.43842094
94	double-strand break repair via homologous recombination (GO:0000724)	2.43571811
95	neurofilament cytoskeleton organization (GO:0060052)	2.41929828
96	reciprocal DNA recombination (GO:0035825)	2.41460421
97	reciprocal meiotic recombination (GO:0007131)	2.41460421
98	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.37587266
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.37587266
100	organic cation transport (GO:0015695)	2.37283949

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	4.22289934
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.02177747
3	* VDR_22108803_ChIP-Seq_LS180_Human	2.92122664
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.89675286
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70370638
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.66477603
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52060461
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52036811
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.23824942
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18730365
11	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13540343
12	EWS_26573619_Chip-Seq_HEK293_Human	2.12655240
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11074380
14	* IGF1R_20145208_ChIP-Seq_DFB_Human	2.02942822
15	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02651769
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.98295969
17	P300_19829295_ChIP-Seq_ESCs_Human	1.94438945
18	FUS_26573619_Chip-Seq_HEK293_Human	1.92202847
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.79610283
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.78612858
21	* ER_23166858_ChIP-Seq_MCF-7_Human	1.74899102
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72420205
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72155584
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69891250
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.66027123
26	* BCAT_22108803_ChIP-Seq_LS180_Human	1.57119482
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54463609
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51284143
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50064406
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48965986
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48744130
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.48672283
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48672283
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.47432180
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46175491
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.45585100
37	* STAT3_23295773_ChIP-Seq_U87_Human	1.45009651
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43413980
39	AR_25329375_ChIP-Seq_VCAP_Human	1.43359831
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40463356
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39695906
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.39134775
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38175572
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38175572
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37782020
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37782020
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37725690
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37608712
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.36656128
50	* TCF4_23295773_ChIP-Seq_U87_Human	1.36330806
51	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.35643068
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35012016
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34700025
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34700025
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30556161
56	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.29658493
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28806143
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28580205
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27283651
60	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.26426021
61	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25986773
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25934927
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25884055
64	* TCF4_22108803_ChIP-Seq_LS180_Human	1.25812028
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25133739
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23397889
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22755665
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21546256
69	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.19446638
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19138049
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18831625
72	NCOR_22424771_ChIP-Seq_293T_Human	1.18768184
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18310948
74	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.18058011
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17864489
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16257871
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16033932
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15657411
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15145993
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14665982
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13170497
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12186723
83	AR_20517297_ChIP-Seq_VCAP_Human	1.10979595
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07530133
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06879923
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06390127
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05866695
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03927345
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02383722
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00967249
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99032741
92	VDR_23849224_ChIP-Seq_CD4+_Human	0.98362936
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97524209
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97520826
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96005005
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.94501231
97	* CDX2_22108803_ChIP-Seq_LS180_Human	0.94260343
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92934145
99	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92386717
100	* AR_21572438_ChIP-Seq_LNCaP_Human	0.90936615

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	2.92911502
2	MP0008877_abnormal_DNA_methylation	2.90038151
3	MP0002102_abnormal_ear_morphology	2.64586662
4	MP0005551_abnormal_eye_electrophysiolog	2.49320417
5	MP0008875_abnormal_xenobiotic_pharmacok	2.43240236
6	MP0001968_abnormal_touch/_nociception	2.42307726
7	MP0001986_abnormal_taste_sensitivity	2.39929440
8	MP0008872_abnormal_physiological_respon	2.33041769
9	MP0002876_abnormal_thyroid_physiology	2.30999300
10	MP0009046_muscle_twitch	2.30385353
11	MP0000569_abnormal_digit_pigmentation	2.29878432
12	MP0003787_abnormal_imprinting	2.12554522
13	MP0002736_abnormal_nociception_after	2.09830799
14	MP0006072_abnormal_retinal_apoptosis	2.07196038
15	MP0002653_abnormal_ependyma_morphology	2.06394797
16	MP0004885_abnormal_endolymph	2.05234333
17	MP0006292_abnormal_olfactory_placode	2.04485495
18	MP0003646_muscle_fatigue	1.97857157
19	MP0003136_yellow_coat_color	1.94453411
20	MP0009745_abnormal_behavioral_response	1.94068339
21	MP0002837_dystrophic_cardiac_calcinosis	1.91807198
22	MP0005645_abnormal_hypothalamus_physiol	1.89725542
23	MP0004142_abnormal_muscle_tone	1.89389850
24	MP0005253_abnormal_eye_physiology	1.75333231
25	MP0004043_abnormal_pH_regulation	1.72453324
26	MP0005646_abnormal_pituitary_gland	1.70914276
27	MP0002938_white_spotting	1.69640453
28	MP0002272_abnormal_nervous_system	1.67000450
29	MP0002735_abnormal_chemical_nociception	1.63022761
30	MP0004133_heterotaxia	1.62990602
31	MP0002638_abnormal_pupillary_reflex	1.62228949
32	MP0008995_early_reproductive_senescence	1.61559546
33	MP0001984_abnormal_olfaction	1.57820872
34	MP0006276_abnormal_autonomic_nervous	1.56818471
35	MP0004147_increased_porphyrin_level	1.55111266
36	MP0004742_abnormal_vestibular_system	1.54872412
37	MP0000427_abnormal_hair_cycle	1.54219495
38	MP0003880_abnormal_central_pattern	1.53960274
39	MP0000372_irregular_coat_pigmentation	1.52861462
40	MP0001486_abnormal_startle_reflex	1.48634560
41	MP0001501_abnormal_sleep_pattern	1.42953965
42	MP0001485_abnormal_pinna_reflex	1.39884773
43	MP0000631_abnormal_neuroendocrine_gland	1.36980955
44	MP0005174_abnormal_tail_pigmentation	1.36744720
45	MP0002572_abnormal_emotion/affect_behav	1.31837520
46	MP0002064_seizures	1.28867298
47	MP0001970_abnormal_pain_threshold	1.26347031
48	MP0002163_abnormal_gland_morphology	1.25982644
49	MP0001529_abnormal_vocalization	1.25864629
50	MP0002733_abnormal_thermal_nociception	1.23772342
51	MP0002557_abnormal_social/conspecific_i	1.23304601
52	MP0005389_reproductive_system_phenotype	1.21467814
53	MP0003011_delayed_dark_adaptation	1.20890818
54	MP0003718_maternal_effect	1.19746290
55	MP0002160_abnormal_reproductive_system	1.18872394
56	MP0002067_abnormal_sensory_capabilities	1.17404184
57	MP0005085_abnormal_gallbladder_physiolo	1.15899251
58	MP0005084_abnormal_gallbladder_morpholo	1.14895063
59	MP0005386_behavior/neurological_phenoty	1.13732380
60	MP0004924_abnormal_behavior	1.13732380
61	MP0005410_abnormal_fertilization	1.12246222
62	MP0003252_abnormal_bile_duct	1.11692330
63	MP0005379_endocrine/exocrine_gland_phen	1.08064154
64	MP0010386_abnormal_urinary_bladder	1.06204961
65	MP0001905_abnormal_dopamine_level	1.06004046
66	MP0002234_abnormal_pharynx_morphology	1.05753921
67	MP0005423_abnormal_somatic_nervous	1.04082789
68	MP0002928_abnormal_bile_duct	1.03195639
69	MP0004145_abnormal_muscle_electrophysio	1.01790400
70	MP0002734_abnormal_mechanical_nocicepti	0.99122739
71	MP0005075_abnormal_melanosome_morpholog	0.97579870
72	MP0002063_abnormal_learning/memory/cond	0.97353625
73	MP0005195_abnormal_posterior_eye	0.97109408
74	MP0000230_abnormal_systemic_arterial	0.96111142
75	MP0001919_abnormal_reproductive_system	0.95895477
76	MP0002095_abnormal_skin_pigmentation	0.94768524
77	MP0003283_abnormal_digestive_organ	0.94472064
78	MP0003635_abnormal_synaptic_transmissio	0.94256407
79	MP0002277_abnormal_respiratory_mucosa	0.92541268
80	MP0005360_urolithiasis	0.91698256
81	MP0008775_abnormal_heart_ventricle	0.91673312
82	MP0003890_abnormal_embryonic-extraembry	0.91423029
83	MP0003698_abnormal_male_reproductive	0.89703494
84	MP0000026_abnormal_inner_ear	0.88498631
85	MP0005332_abnormal_amino_acid	0.87415231
86	MP0002751_abnormal_autonomic_nervous	0.86529528
87	MP0002909_abnormal_adrenal_gland	0.86147016
88	MP0002752_abnormal_somatic_nervous	0.85755384
89	MP0005167_abnormal_blood-brain_barrier	0.85555422
90	MP0003121_genomic_imprinting	0.85391386
91	MP0001440_abnormal_grooming_behavior	0.83916128
92	MP0008789_abnormal_olfactory_epithelium	0.83901494
93	MP0002693_abnormal_pancreas_physiology	0.83616722
94	MP0001929_abnormal_gametogenesis	0.82915014
95	MP0004215_abnormal_myocardial_fiber	0.82549387
96	MP0000538_abnormal_urinary_bladder	0.82432465
97	MP0002254_reproductive_system_inflammat	0.81116592
98	MP0002210_abnormal_sex_determination	0.80739534
99	MP0002138_abnormal_hepatobiliary_system	0.79687413
100	MP0002229_neurodegeneration	0.78927294

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.59321360
2	Congenital stationary night blindness (HP:0007642)	4.23664588
3	Molar tooth sign on MRI (HP:0002419)	4.21839208
4	Abnormality of midbrain morphology (HP:0002418)	4.21839208
5	Pancreatic fibrosis (HP:0100732)	4.12745802
6	True hermaphroditism (HP:0010459)	3.98082506
7	Nephronophthisis (HP:0000090)	3.63564545
8	Abnormality of the renal cortex (HP:0011035)	3.39023176
9	Type II lissencephaly (HP:0007260)	3.33199079
10	Hyperventilation (HP:0002883)	3.18831648
11	Abnormality of the renal medulla (HP:0100957)	3.14044372
12	Medial flaring of the eyebrow (HP:0010747)	3.02838336
13	Attenuation of retinal blood vessels (HP:0007843)	2.95672123
14	Abnormal rod and cone electroretinograms (HP:0008323)	2.90529959
15	Inability to walk (HP:0002540)	2.89557584
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.86418687
17	Abnormality of alanine metabolism (HP:0010916)	2.86418687
18	Hyperalaninemia (HP:0003348)	2.86418687
19	Cystic liver disease (HP:0006706)	2.81237424
20	Tubular atrophy (HP:0000092)	2.79927199
21	Large for gestational age (HP:0001520)	2.72997423
22	Pendular nystagmus (HP:0012043)	2.72496061
23	Abolished electroretinogram (ERG) (HP:0000550)	2.70066000
24	Renal cortical cysts (HP:0000803)	2.57526205
25	Chronic hepatic failure (HP:0100626)	2.49010760
26	Increased corneal curvature (HP:0100692)	2.47588134
27	Keratoconus (HP:0000563)	2.47588134
28	Duplicated collecting system (HP:0000081)	2.44152794
29	Polydipsia (HP:0001959)	2.43951534
30	Abnormal drinking behavior (HP:0030082)	2.43951534
31	Gait imbalance (HP:0002141)	2.41273071
32	Abnormality of the renal collecting system (HP:0004742)	2.38836604
33	Gaze-evoked nystagmus (HP:0000640)	2.37815038
34	Sclerocornea (HP:0000647)	2.36309881
35	Progressive inability to walk (HP:0002505)	2.35083451
36	Congenital primary aphakia (HP:0007707)	2.34645145
37	Congenital, generalized hypertrichosis (HP:0004540)	2.34103051
38	Furrowed tongue (HP:0000221)	2.31438659
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.26851703
40	Lissencephaly (HP:0001339)	2.25606892
41	Cerebellar dysplasia (HP:0007033)	2.23868384
42	Stomach cancer (HP:0012126)	2.22948960
43	Nephrogenic diabetes insipidus (HP:0009806)	2.20537653
44	Absent/shortened dynein arms (HP:0200106)	2.18869077
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18869077
46	Anencephaly (HP:0002323)	2.16717916
47	Decreased central vision (HP:0007663)	2.15848948
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.13708547
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13650434
50	Broad-based gait (HP:0002136)	2.07509771
51	Severe muscular hypotonia (HP:0006829)	2.06974537
52	Male pseudohermaphroditism (HP:0000037)	2.06626939
53	Congenital sensorineural hearing impairment (HP:0008527)	2.06337315
54	Progressive cerebellar ataxia (HP:0002073)	2.05168151
55	Hypoplasia of the fovea (HP:0007750)	2.04980047
56	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.04980047
57	Optic nerve hypoplasia (HP:0000609)	2.02285799
58	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.01874403
59	Congenital hepatic fibrosis (HP:0002612)	2.01619068
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.01554850
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01408168
62	Concave nail (HP:0001598)	2.00025434
63	Genital tract atresia (HP:0001827)	2.00003201
64	Polyuria (HP:0000103)	1.99874797
65	Abnormality of the pons (HP:0007361)	1.97977067
66	Abnormal biliary tract physiology (HP:0012439)	1.96807081
67	Bile duct proliferation (HP:0001408)	1.96807081
68	Postaxial foot polydactyly (HP:0001830)	1.94713907
69	Febrile seizures (HP:0002373)	1.92635211
70	Acute necrotizing encephalopathy (HP:0006965)	1.92461635
71	Hypothermia (HP:0002045)	1.92117582
72	Mitochondrial inheritance (HP:0001427)	1.91432859
73	Absent thumb (HP:0009777)	1.90942156
74	Vaginal atresia (HP:0000148)	1.90855548
75	Increased CSF lactate (HP:0002490)	1.89791399
76	Genetic anticipation (HP:0003743)	1.89377165
77	Hemiparesis (HP:0001269)	1.89300081
78	Clumsiness (HP:0002312)	1.88333245
79	Thyroid-stimulating hormone excess (HP:0002925)	1.87485198
80	Hypoplasia of the pons (HP:0012110)	1.86912380
81	Decreased circulating renin level (HP:0003351)	1.86402022
82	Abnormal respiratory motile cilium morphology (HP:0005938)	1.85364764
83	Abnormal respiratory epithelium morphology (HP:0012253)	1.85364764
84	3-Methylglutaconic aciduria (HP:0003535)	1.84407925
85	Pachygyria (HP:0001302)	1.83744521
86	Abnormality of the ileum (HP:0001549)	1.82689993
87	Intestinal atresia (HP:0011100)	1.81923238
88	Chorioretinal atrophy (HP:0000533)	1.81015525
89	Bony spicule pigmentary retinopathy (HP:0007737)	1.80899350
90	Methylmalonic acidemia (HP:0002912)	1.80693095
91	Hyperglycinuria (HP:0003108)	1.78238932
92	Disproportionate short-trunk short stature (HP:0003521)	1.77113570
93	Acute encephalopathy (HP:0006846)	1.76113688
94	Progressive macrocephaly (HP:0004481)	1.75395314
95	Meckel diverticulum (HP:0002245)	1.74762479
96	Absent speech (HP:0001344)	1.73526874
97	Retinal dysplasia (HP:0007973)	1.72319534
98	Patellar aplasia (HP:0006443)	1.71704382
99	Optic disc pallor (HP:0000543)	1.70946853
100	Fair hair (HP:0002286)	1.67804803

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.33368926
2	TAOK3	3.73313691
3	ADRBK2	3.65697653
4	MAP4K2	3.04619754
5	BMPR1B	2.77900540
6	ACVR1B	2.75637367
7	ZAK	2.75059645
8	GRK1	2.74780167
9	WNK3	2.62115014
10	WNK4	2.42545544
11	NUAK1	2.31760742
12	TLK1	2.30414558
13	TXK	2.18329531
14	PINK1	2.07709534
15	MAPK13	1.95176641
16	CASK	1.84908513
17	INSRR	1.63258951
18	OXSR1	1.48224431
19	TRIM28	1.44472216
20	STK39	1.43523516
21	MAP3K4	1.38368655
22	NTRK3	1.37270911
23	DAPK2	1.34999590
24	BCKDK	1.32003229
25	PNCK	1.22845286
26	CAMKK2	1.21910014
27	MKNK2	1.21803410
28	ADRBK1	1.15544873
29	PAK3	1.09976208
30	TIE1	1.08069158
31	VRK1	1.04535890
32	MAPKAPK3	1.04534874
33	PRKCG	0.98704778
34	TGFBR1	0.98358179
35	PRKCE	0.96955127
36	DYRK2	0.96192459
37	MAPK15	0.91298468
38	MARK1	0.91176110
39	PHKG1	0.91055494
40	PHKG2	0.91055494
41	TNIK	0.89402293
42	STK16	0.86499101
43	MAP2K7	0.76745374
44	CSNK1G1	0.76121471
45	CSNK1G2	0.75734389
46	FGFR2	0.73182738
47	CSNK1G3	0.71896189
48	MAP2K6	0.71539110
49	PLK2	0.71095807
50	VRK2	0.70762490
51	TEC	0.69895926
52	ITK	0.68810482
53	PTK2B	0.66543915
54	PIK3CA	0.65220750
55	MAP4K1	0.64912815
56	BRSK2	0.63699630
57	IKBKB	0.63543026
58	STK38L	0.62689781
59	BCR	0.62024685
60	MAPKAPK5	0.61692303
61	STK3	0.60966276
62	EPHA4	0.60862105
63	ERBB3	0.60489569
64	IRAK1	0.59433018
65	PLK3	0.57319139
66	PRKCI	0.56185781
67	MST4	0.55116041
68	MUSK	0.54810815
69	CSNK1A1L	0.54537024
70	WEE1	0.53807492
71	NTRK2	0.52828987
72	PRKCQ	0.51318497
73	MKNK1	0.50082532
74	CAMK2A	0.49273633
75	PLK4	0.48069370
76	RPS6KA5	0.46857337
77	PKN1	0.44150196
78	NLK	0.43742794
79	STK11	0.43361254
80	NEK2	0.42726730
81	PRKACA	0.41494894
82	EIF2AK3	0.40257304
83	GRK7	0.39309979
84	PRKCZ	0.37072629
85	CAMK1	0.36799039
86	CSNK1A1	0.33307089
87	PRKCA	0.32223582
88	TSSK6	0.30871941
89	TRPM7	0.30851958
90	EPHA3	0.30581421
91	CSNK1D	0.30450363
92	KIT	0.29646111
93	PRKAA1	0.29429524
94	CHUK	0.29192703
95	OBSCN	0.28172838
96	IGF1R	0.27954661
97	PRKG1	0.27930705
98	GRK5	0.27454987
99	SYK	0.27444400
100	PRKAA2	0.27400494

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.80451697
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.60589495
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.57774970
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.54021801
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.50350374
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.40978186
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.33901382
8	Butanoate metabolism_Homo sapiens_hsa00650	2.31627615
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.23464083
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.11522817
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10679000
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.08662486
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.03231410
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.98731132
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95898794
16	Nicotine addiction_Homo sapiens_hsa05033	1.95483374
17	Caffeine metabolism_Homo sapiens_hsa00232	1.89959394
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.88154328
19	Basal transcription factors_Homo sapiens_hsa03022	1.76425731
20	Protein export_Homo sapiens_hsa03060	1.74493858
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.69856516
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.67689540
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62369726
24	RNA polymerase_Homo sapiens_hsa03020	1.56422350
25	Homologous recombination_Homo sapiens_hsa03440	1.49415827
26	Parkinsons disease_Homo sapiens_hsa05012	1.48402254
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.37621753
28	Taste transduction_Homo sapiens_hsa04742	1.36500125
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32967742
30	Propanoate metabolism_Homo sapiens_hsa00640	1.31851880
31	Morphine addiction_Homo sapiens_hsa05032	1.26987070
32	Olfactory transduction_Homo sapiens_hsa04740	1.26871462
33	Peroxisome_Homo sapiens_hsa04146	1.26639288
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25802370
35	RNA degradation_Homo sapiens_hsa03018	1.20393964
36	Regulation of autophagy_Homo sapiens_hsa04140	1.15675918
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14647464
38	ABC transporters_Homo sapiens_hsa02010	1.14025266
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11867561
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.09982716
41	Insulin secretion_Homo sapiens_hsa04911	1.07875475
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07022400
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06006016
44	Fat digestion and absorption_Homo sapiens_hsa04975	1.05114943
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01273580
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99392035
47	GABAergic synapse_Homo sapiens_hsa04727	0.95873263
48	Sulfur metabolism_Homo sapiens_hsa00920	0.95721793
49	Serotonergic synapse_Homo sapiens_hsa04726	0.94703364
50	Retinol metabolism_Homo sapiens_hsa00830	0.91987607
51	One carbon pool by folate_Homo sapiens_hsa00670	0.91194104
52	Huntingtons disease_Homo sapiens_hsa05016	0.90690185
53	Asthma_Homo sapiens_hsa05310	0.89699469
54	Circadian entrainment_Homo sapiens_hsa04713	0.89621802
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86909551
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86566253
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85121946
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.83529236
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83269487
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.83226803
61	Alzheimers disease_Homo sapiens_hsa05010	0.81408749
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78065006
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75017244
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.74095652
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73050363
66	Histidine metabolism_Homo sapiens_hsa00340	0.72014471
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71218548
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69952735
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69652996
70	Salivary secretion_Homo sapiens_hsa04970	0.69069531
71	Purine metabolism_Homo sapiens_hsa00230	0.64976452
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.64398009
73	Metabolic pathways_Homo sapiens_hsa01100	0.61707831
74	Mineral absorption_Homo sapiens_hsa04978	0.61543183
75	Graft-versus-host disease_Homo sapiens_hsa05332	0.60105276
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.59945997
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.58896586
78	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.57216502
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55058379
80	Allograft rejection_Homo sapiens_hsa05330	0.52905182
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52296599
82	Sulfur relay system_Homo sapiens_hsa04122	0.50247623
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49707595
84	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49687570
85	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49298512
86	Proteasome_Homo sapiens_hsa03050	0.48103542
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48054651
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47979217
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.46707219
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46505459
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46188112
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45937893
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.44672938
94	Circadian rhythm_Homo sapiens_hsa04710	0.38196512
95	Cocaine addiction_Homo sapiens_hsa05030	0.37485509
96	Fatty acid degradation_Homo sapiens_hsa00071	0.34531312
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.33581220
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32914017
99	Long-term depression_Homo sapiens_hsa04730	0.31128566
100	Amphetamine addiction_Homo sapiens_hsa05031	0.29936433

ZNF716

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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