ZNF718

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.02562465
2behavioral response to nicotine (GO:0035095)4.30901649
3negative regulation of telomere maintenance (GO:0032205)4.29343679
4protein neddylation (GO:0045116)4.12033676
5kinetochore assembly (GO:0051382)3.97438568
6somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.87479871
7isotype switching (GO:0045190)3.87479871
8somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.87479871
9response to pheromone (GO:0019236)3.87466979
10chromatin remodeling at centromere (GO:0031055)3.77095359
11kinetochore organization (GO:0051383)3.73521776
12DNA deamination (GO:0045006)3.67202518
13replication fork processing (GO:0031297)3.66611626
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.63920015
15regulation of mitotic spindle checkpoint (GO:1903504)3.61943693
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61943693
17CENP-A containing nucleosome assembly (GO:0034080)3.60379514
18nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51999073
19regulation of telomere maintenance via telomerase (GO:0032210)3.44367873
20L-fucose metabolic process (GO:0042354)3.43343783
21L-fucose catabolic process (GO:0042355)3.43343783
22fucose catabolic process (GO:0019317)3.43343783
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40429695
24nonmotile primary cilium assembly (GO:0035058)3.33988180
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.32643894
26regulation of translation, ncRNA-mediated (GO:0045974)3.32643894
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.32643894
28regulation of telomere maintenance (GO:0032204)3.31621339
29platelet dense granule organization (GO:0060155)3.30871912
30histone exchange (GO:0043486)3.28095089
31somatic hypermutation of immunoglobulin genes (GO:0016446)3.18323680
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18323680
33recombinational repair (GO:0000725)3.17624426
34double-strand break repair via homologous recombination (GO:0000724)3.16011543
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.14489626
36DNA catabolic process, exonucleolytic (GO:0000738)3.13945759
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.12792123
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10810399
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10810399
40regulation of posttranscriptional gene silencing (GO:0060147)3.10483208
41regulation of gene silencing by miRNA (GO:0060964)3.10483208
42regulation of gene silencing by RNA (GO:0060966)3.10483208
43regulation of cilium movement (GO:0003352)3.08008851
44somatic recombination of immunoglobulin gene segments (GO:0016447)3.07664348
45intraciliary transport (GO:0042073)3.05948654
46preassembly of GPI anchor in ER membrane (GO:0016254)3.05056220
47somite development (GO:0061053)2.98473110
48somatic diversification of immunoglobulins (GO:0016445)2.96034779
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95372809
50centriole replication (GO:0007099)2.94773947
51maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93735245
52synapsis (GO:0007129)2.92881792
53peptidyl-histidine modification (GO:0018202)2.81347125
54DNA ligation (GO:0006266)2.81117698
55somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.80929502
56somatic cell DNA recombination (GO:0016444)2.80929502
57negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.80189249
58cilium morphogenesis (GO:0060271)2.77045268
59kidney morphogenesis (GO:0060993)2.76164715
60mannosylation (GO:0097502)2.76135047
61DNA replication checkpoint (GO:0000076)2.75760358
62pyrimidine nucleobase catabolic process (GO:0006208)2.74902898
63somatic diversification of immune receptors (GO:0002200)2.74758272
64microtubule depolymerization (GO:0007019)2.68738881
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.68166808
66DNA replication-dependent nucleosome organization (GO:0034723)2.67858422
67DNA replication-dependent nucleosome assembly (GO:0006335)2.67858422
68reciprocal DNA recombination (GO:0035825)2.67470453
69reciprocal meiotic recombination (GO:0007131)2.67470453
70ncRNA catabolic process (GO:0034661)2.67069851
71negative regulation of DNA recombination (GO:0045910)2.66431940
72histone mRNA metabolic process (GO:0008334)2.66424999
73regulation of centriole replication (GO:0046599)2.63615954
74DNA replication-independent nucleosome organization (GO:0034724)2.61350744
75DNA replication-independent nucleosome assembly (GO:0006336)2.61350744
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60401073
77respiratory chain complex IV assembly (GO:0008535)2.59644876
78sulfation (GO:0051923)2.58569908
79protein-cofactor linkage (GO:0018065)2.56500411
80mismatch repair (GO:0006298)2.55507854
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55308268
82photoreceptor cell maintenance (GO:0045494)2.53990837
83DNA damage response, detection of DNA damage (GO:0042769)2.53459680
84DNA recombination (GO:0006310)2.51020835
85DNA integration (GO:0015074)2.50996508
86protein prenylation (GO:0018342)2.49139276
87prenylation (GO:0097354)2.49139276
88protein K6-linked ubiquitination (GO:0085020)2.48807515
89neural tube formation (GO:0001841)2.48657551
90GPI anchor metabolic process (GO:0006505)2.48590595
91isoprenoid biosynthetic process (GO:0008299)2.48480027
92DNA demethylation (GO:0080111)2.48079257
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43888407
94centrosome organization (GO:0051297)2.42938344
95regulation of helicase activity (GO:0051095)2.42909989
96epithelial cilium movement (GO:0003351)2.42789722
97resolution of meiotic recombination intermediates (GO:0000712)2.42499962
98regulation of mesoderm development (GO:2000380)2.40596780
99cilium organization (GO:0044782)2.40203201
100ubiquinone metabolic process (GO:0006743)2.39866139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZNF274_21170338_ChIP-Seq_K562_Hela3.79330996
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74006780
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73767661
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.69790769
5IGF1R_20145208_ChIP-Seq_DFB_Human2.66326114
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64699473
7GBX2_23144817_ChIP-Seq_PC3_Human2.63598856
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.62136318
9TAF15_26573619_Chip-Seq_HEK293_Human2.55990703
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.55539491
11FUS_26573619_Chip-Seq_HEK293_Human2.50959014
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49120366
13EWS_26573619_Chip-Seq_HEK293_Human2.44231871
14VDR_22108803_ChIP-Seq_LS180_Human2.41230446
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38631435
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36814485
17ELK1_19687146_ChIP-ChIP_HELA_Human2.34562509
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34429369
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.32746642
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27352480
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16437550
22E2F7_22180533_ChIP-Seq_HELA_Human2.12539193
23IRF1_19129219_ChIP-ChIP_H3396_Human2.06491837
24P300_19829295_ChIP-Seq_ESCs_Human1.98577939
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92145575
26* VDR_23849224_ChIP-Seq_CD4+_Human1.88562563
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85461761
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84296621
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82523426
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82172431
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81765415
32MYC_18940864_ChIP-ChIP_HL60_Human1.78569450
33* ER_23166858_ChIP-Seq_MCF-7_Human1.76976641
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74185163
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54512662
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52022530
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51303818
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.48859815
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.48423193
40FOXP3_21729870_ChIP-Seq_TREG_Human1.48121994
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47136327
42* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44896504
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39618412
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37278068
45BCAT_22108803_ChIP-Seq_LS180_Human1.36473502
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34407887
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32949388
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32518634
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.30991158
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.28995914
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28426882
52CBP_20019798_ChIP-Seq_JUKART_Human1.28426882
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28111821
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27475424
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.26048737
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.23885524
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.23572910
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.23418294
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22246223
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22246223
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19726692
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19719991
63TP53_22573176_ChIP-Seq_HFKS_Human1.18520737
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17545128
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16162294
66SOX2_19829295_ChIP-Seq_ESCs_Human1.15415768
67NANOG_19829295_ChIP-Seq_ESCs_Human1.15415768
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14102148
69AR_25329375_ChIP-Seq_VCAP_Human1.13830002
70TCF4_22108803_ChIP-Seq_LS180_Human1.13139082
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12566185
72* STAT3_23295773_ChIP-Seq_U87_Human1.10751305
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.10640717
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10640717
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10147039
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08603302
77EZH2_22144423_ChIP-Seq_EOC_Human1.07831869
78RUNX2_22187159_ChIP-Seq_PCA_Human1.07116869
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05727866
80TCF4_23295773_ChIP-Seq_U87_Human1.05341188
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04324899
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.04261543
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03753662
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02938237
85P53_22387025_ChIP-Seq_ESCs_Mouse1.01832517
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.01432023
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98990230
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.98786709
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97818187
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95636847
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95234357
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.93433137
93HOXB7_26014856_ChIP-Seq_BT474_Human0.93126274
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92929703
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.92751548
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.92737060
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.91199322
98RNF2_27304074_Chip-Seq_NSC_Mouse0.90851355
99AR_20517297_ChIP-Seq_VCAP_Human0.90119883
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88658176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.20348271
2MP0008877_abnormal_DNA_methylation3.09507187
3MP0006292_abnormal_olfactory_placode3.08194847
4MP0010094_abnormal_chromosome_stability2.62936132
5MP0008058_abnormal_DNA_repair2.56113785
6MP0006072_abnormal_retinal_apoptosis2.40967623
7MP0009697_abnormal_copulation2.37993127
8MP0001529_abnormal_vocalization2.35508146
9MP0004147_increased_porphyrin_level2.30569203
10MP0008789_abnormal_olfactory_epithelium2.29624488
11MP0005394_taste/olfaction_phenotype2.08335075
12MP0005499_abnormal_olfactory_system2.08335075
13MP0002938_white_spotting2.07907715
14MP0000372_irregular_coat_pigmentation1.95506605
15MP0001188_hyperpigmentation1.92077613
16MP0001293_anophthalmia1.92069895
17MP0005075_abnormal_melanosome_morpholog1.88965266
18MP0001984_abnormal_olfaction1.86744160
19MP0003011_delayed_dark_adaptation1.83516938
20MP0005646_abnormal_pituitary_gland1.80566778
21MP0003890_abnormal_embryonic-extraembry1.72534146
22MP0003787_abnormal_imprinting1.69777540
23MP0003718_maternal_effect1.67126804
24MP0005174_abnormal_tail_pigmentation1.66261129
25MP0005253_abnormal_eye_physiology1.64331586
26MP0003136_yellow_coat_color1.60327924
27MP0005084_abnormal_gallbladder_morpholo1.57453294
28MP0000427_abnormal_hair_cycle1.55269263
29MP0002736_abnormal_nociception_after1.54769207
30MP0008057_abnormal_DNA_replication1.49983615
31MP0005551_abnormal_eye_electrophysiolog1.46644724
32MP0002751_abnormal_autonomic_nervous1.43967371
33MP0002234_abnormal_pharynx_morphology1.43802099
34MP0003693_abnormal_embryo_hatching1.42711408
35MP0002837_dystrophic_cardiac_calcinosis1.41790214
36MP0002653_abnormal_ependyma_morphology1.40952503
37MP0001968_abnormal_touch/_nociception1.40558279
38MP0000383_abnormal_hair_follicle1.40254973
39MP0004133_heterotaxia1.38632780
40MP0003195_calcinosis1.35835942
41MP0003111_abnormal_nucleus_morphology1.34781891
42MP0003937_abnormal_limbs/digits/tail_de1.31981025
43MP0002095_abnormal_skin_pigmentation1.29680085
44MP0000631_abnormal_neuroendocrine_gland1.28662796
45MP0003567_abnormal_fetal_cardiomyocyte1.28044821
46MP0002233_abnormal_nose_morphology1.27431573
47MP0003119_abnormal_digestive_system1.25363440
48MP0000569_abnormal_digit_pigmentation1.24597979
49MP0001485_abnormal_pinna_reflex1.24117005
50MP0008932_abnormal_embryonic_tissue1.22666752
51MP0008007_abnormal_cellular_replicative1.21138363
52MP0001986_abnormal_taste_sensitivity1.18719542
53MP0008995_early_reproductive_senescence1.16309472
54MP0008872_abnormal_physiological_respon1.15634135
55MP0005248_abnormal_Harderian_gland1.14686117
56MP0003283_abnormal_digestive_organ1.13846416
57MP0004885_abnormal_endolymph1.13252570
58MP0004142_abnormal_muscle_tone1.13236676
59MP0006276_abnormal_autonomic_nervous1.10926647
60MP0003121_genomic_imprinting1.07831250
61MP0002163_abnormal_gland_morphology1.03999475
62MP0001929_abnormal_gametogenesis1.01962330
63MP0005391_vision/eye_phenotype1.00406760
64MP0010386_abnormal_urinary_bladder1.00007218
65MP0000647_abnormal_sebaceous_gland0.98885661
66MP0003941_abnormal_skin_development0.98866771
67MP0002160_abnormal_reproductive_system0.98784648
68MP0003077_abnormal_cell_cycle0.98119479
69MP0002210_abnormal_sex_determination0.94344461
70MP0001486_abnormal_startle_reflex0.94082775
71MP0001764_abnormal_homeostasis0.92539309
72MP0003786_premature_aging0.91782240
73MP0001919_abnormal_reproductive_system0.91766772
74MP0005410_abnormal_fertilization0.91652466
75MP0004215_abnormal_myocardial_fiber0.90011856
76MP0000778_abnormal_nervous_system0.89893243
77MP0005389_reproductive_system_phenotype0.89623696
78MP0003698_abnormal_male_reproductive0.87141244
79MP0009745_abnormal_behavioral_response0.86997623
80MP0005187_abnormal_penis_morphology0.86378733
81MP0000653_abnormal_sex_gland0.85744964
82MP0006035_abnormal_mitochondrial_morpho0.85695975
83MP0000049_abnormal_middle_ear0.84627070
84MP0002009_preneoplasia0.83478616
85MP0001145_abnormal_male_reproductive0.83221539
86MP0005645_abnormal_hypothalamus_physiol0.82880457
87MP0003880_abnormal_central_pattern0.82241541
88MP0001119_abnormal_female_reproductive0.82033245
89MP0001286_abnormal_eye_development0.82012093
90MP0002277_abnormal_respiratory_mucosa0.80593216
91MP0005195_abnormal_posterior_eye0.79426672
92MP0009046_muscle_twitch0.79285819
93MP0000566_synostosis0.78895202
94MP0002638_abnormal_pupillary_reflex0.78597884
95MP0005379_endocrine/exocrine_gland_phen0.78179770
96MP0002272_abnormal_nervous_system0.75314308
97MP0004957_abnormal_blastocyst_morpholog0.74493135
98MP0002557_abnormal_social/conspecific_i0.73720151
99MP0004197_abnormal_fetal_growth/weight/0.73671510
100MP0004742_abnormal_vestibular_system0.72419181

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.68134222
2Pancreatic cysts (HP:0001737)3.55402525
3Nephronophthisis (HP:0000090)3.40676515
4Pancreatic fibrosis (HP:0100732)3.34520733
5Molar tooth sign on MRI (HP:0002419)3.29858687
6Abnormality of midbrain morphology (HP:0002418)3.29858687
7True hermaphroditism (HP:0010459)3.22442999
8Medial flaring of the eyebrow (HP:0010747)3.07478767
9Abnormality of the renal medulla (HP:0100957)2.99252518
10Abnormality of the labia minora (HP:0012880)2.85977090
11Congenital primary aphakia (HP:0007707)2.83210480
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.77576935
13Gait imbalance (HP:0002141)2.72868748
14Chronic hepatic failure (HP:0100626)2.66759224
15Nephrogenic diabetes insipidus (HP:0009806)2.63359864
16Abnormality of the ileum (HP:0001549)2.62243737
17Abnormality of chromosome stability (HP:0003220)2.58097896
18Meckel diverticulum (HP:0002245)2.55129509
19Abnormality of the renal cortex (HP:0011035)2.44545636
20Vaginal atresia (HP:0000148)2.39443699
21Genital tract atresia (HP:0001827)2.38357703
22Abolished electroretinogram (ERG) (HP:0000550)2.37406548
23Aplasia/Hypoplasia of the tongue (HP:0010295)2.34076552
24Hyperglycinemia (HP:0002154)2.30454266
25IgG deficiency (HP:0004315)2.27176531
26Bile duct proliferation (HP:0001408)2.26648221
27Abnormal biliary tract physiology (HP:0012439)2.26648221
28Renal cortical cysts (HP:0000803)2.26163932
29Poor coordination (HP:0002370)2.24988759
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24655302
31Birth length less than 3rd percentile (HP:0003561)2.22265816
32Pendular nystagmus (HP:0012043)2.21318207
33Ectopic kidney (HP:0000086)2.18969674
34Postaxial foot polydactyly (HP:0001830)2.17642084
35Abnormality of the preputium (HP:0100587)2.15893222
36Inability to walk (HP:0002540)2.15574284
37Stomach cancer (HP:0012126)2.13525505
38Anencephaly (HP:0002323)2.12422992
39Chromsome breakage (HP:0040012)2.11638292
40Volvulus (HP:0002580)2.08581526
41Bilateral microphthalmos (HP:0007633)2.08165362
42Clubbing of toes (HP:0100760)2.05861064
43Duodenal stenosis (HP:0100867)2.04855586
44Small intestinal stenosis (HP:0012848)2.04855586
45Thyroiditis (HP:0100646)2.03442143
46Triphalangeal thumb (HP:0001199)2.02694039
47Intestinal atresia (HP:0011100)2.01866138
48Postaxial hand polydactyly (HP:0001162)2.01009392
49Sloping forehead (HP:0000340)2.00518592
50Preaxial hand polydactyly (HP:0001177)1.99713418
51Aplasia/Hypoplasia of the tibia (HP:0005772)1.97628755
52Panhypogammaglobulinemia (HP:0003139)1.97294996
53Lissencephaly (HP:0001339)1.95634030
54Sclerocornea (HP:0000647)1.95576118
55Congenital hepatic fibrosis (HP:0002612)1.95057569
56Lipid accumulation in hepatocytes (HP:0006561)1.93948074
57Cystic liver disease (HP:0006706)1.91842687
58Type II lissencephaly (HP:0007260)1.91306209
59Acute encephalopathy (HP:0006846)1.90876159
60Abnormality of the duodenum (HP:0002246)1.90323788
61Acute necrotizing encephalopathy (HP:0006965)1.90315951
62Optic nerve hypoplasia (HP:0000609)1.88980029
63Progressive inability to walk (HP:0002505)1.86221679
64Absent thumb (HP:0009777)1.84402642
65Short tibia (HP:0005736)1.83044428
66Abnormality of the metopic suture (HP:0005556)1.82235083
67Abnormal glycosylation (HP:0012345)1.82192255
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82192255
69Abnormal protein N-linked glycosylation (HP:0012347)1.82192255
70Abnormal protein glycosylation (HP:0012346)1.82192255
71Neoplasm of the adrenal cortex (HP:0100641)1.81851133
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81755984
73Broad foot (HP:0001769)1.81505811
74Retinal dysplasia (HP:0007973)1.80971350
75Methylmalonic acidemia (HP:0002912)1.80342363
76Progressive macrocephaly (HP:0004481)1.78632366
77Type I transferrin isoform profile (HP:0003642)1.77962893
78Attenuation of retinal blood vessels (HP:0007843)1.77940552
79Median cleft lip (HP:0000161)1.77698428
80Increased hepatocellular lipid droplets (HP:0006565)1.77366673
81Specific learning disability (HP:0001328)1.76275805
82High anterior hairline (HP:0009890)1.76127887
83Abnormality of the carotid arteries (HP:0005344)1.75918403
84Congenital stationary night blindness (HP:0007642)1.75456170
85Bifid tongue (HP:0010297)1.74183672
86Abnormality of the pons (HP:0007361)1.73856011
873-Methylglutaconic aciduria (HP:0003535)1.73523394
88Male pseudohermaphroditism (HP:0000037)1.73495676
89Thyroid-stimulating hormone excess (HP:0002925)1.73013183
90Hyperglycinuria (HP:0003108)1.72738915
91Astigmatism (HP:0000483)1.72225692
92Dandy-Walker malformation (HP:0001305)1.72196377
93Gaze-evoked nystagmus (HP:0000640)1.71990486
94Decreased central vision (HP:0007663)1.71641762
95Aganglionic megacolon (HP:0002251)1.70435375
96Biliary tract neoplasm (HP:0100574)1.69439329
97Furrowed tongue (HP:0000221)1.69281324
98Abnormality of serine family amino acid metabolism (HP:0010894)1.67638650
99Abnormality of glycine metabolism (HP:0010895)1.67638650
100Mitochondrial inheritance (HP:0001427)1.67139542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.47473341
2ZAK3.49539505
3MAP4K23.17555119
4BMPR1B3.07267678
5FRK2.66163600
6WNK32.38734470
7NUAK12.31855547
8MAP3K42.01206803
9TRIM282.00527648
10MAP2K71.97470697
11PINK11.92204111
12EIF2AK31.89638596
13CDC71.82718515
14ADRBK21.66665045
15SRPK11.65126174
16MKNK21.59889860
17TLK11.58371762
18CASK1.53621748
19ACVR1B1.50909467
20GRK11.49203828
21ERBB31.47454464
22MST41.44179095
23MKNK11.43233390
24TIE11.42391154
25VRK11.41646120
26PLK41.37883011
27TNIK1.34766778
28DYRK31.32183510
29PLK31.29001590
30BRSK21.28989061
31MAPK131.28050297
32TSSK61.26174997
33CSNK1G31.25795496
34BUB11.24956479
35CSNK1G11.22406669
36TGFBR11.20187173
37CSNK1A1L1.19702521
38CSNK1G21.19032977
39TXK1.12382742
40BCR1.09359253
41CDK81.07344204
42TTK1.06330497
43PASK1.02902013
44FLT30.98772409
45DYRK20.98725264
46INSRR0.96706362
47TAF10.94826809
48WEE10.94815072
49RPS6KA40.90547517
50PLK10.89346400
51STK38L0.88013379
52FGFR20.82010681
53NLK0.81850795
54NEK20.79889041
55BCKDK0.76903261
56PLK20.76703934
57ATR0.75922066
58STK30.75316514
59NTRK20.73452450
60PNCK0.72237097
61VRK20.71699828
62PRKCE0.71061659
63MARK30.70214728
64TEC0.69657989
65PIK3CA0.69515512
66ATM0.63547669
67RPS6KA50.62320330
68WNK40.62154964
69CHEK20.62044003
70PAK30.58088316
71AURKB0.57209681
72CDK30.56819314
73TNK20.55405647
74STK160.55124368
75LATS10.53363877
76OXSR10.52105522
77PBK0.51293942
78OBSCN0.50870537
79EIF2AK10.49902192
80KDR0.48704206
81PRKCQ0.46046265
82EPHA30.45838375
83CCNB10.43438639
84KIT0.43307413
85NEK10.41087403
86PRKCG0.40105932
87ADRBK10.37741446
88CSNK1A10.37421296
89EGFR0.35600404
90CSNK1D0.35393682
91YES10.31662774
92MYLK0.31650037
93SGK20.31602514
94CSNK2A10.30220876
95MAP2K40.29456811
96SYK0.28291680
97FGFR10.27328892
98MATK0.26239182
99IGF1R0.25141225
100EIF2AK20.24854143

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.09058883
2Homologous recombination_Homo sapiens_hsa034403.07155546
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.99619950
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.57787708
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51447748
6Protein export_Homo sapiens_hsa030602.48113068
7RNA polymerase_Homo sapiens_hsa030202.45263008
8Basal transcription factors_Homo sapiens_hsa030222.37496074
9Phototransduction_Homo sapiens_hsa047442.35265629
10DNA replication_Homo sapiens_hsa030302.35080521
11Mismatch repair_Homo sapiens_hsa034302.27600746
12Butanoate metabolism_Homo sapiens_hsa006502.16694811
13Non-homologous end-joining_Homo sapiens_hsa034502.08956487
14Steroid biosynthesis_Homo sapiens_hsa001002.08305044
15Proteasome_Homo sapiens_hsa030502.02666114
16RNA degradation_Homo sapiens_hsa030181.91378380
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89390177
18Propanoate metabolism_Homo sapiens_hsa006401.83632418
19Oxidative phosphorylation_Homo sapiens_hsa001901.80998665
20Selenocompound metabolism_Homo sapiens_hsa004501.76692204
21Nucleotide excision repair_Homo sapiens_hsa034201.76600144
22Nitrogen metabolism_Homo sapiens_hsa009101.65477981
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63935783
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60535417
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56650620
26Parkinsons disease_Homo sapiens_hsa050121.48552201
27RNA transport_Homo sapiens_hsa030131.44354762
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42738729
29Nicotine addiction_Homo sapiens_hsa050331.41310595
30Primary immunodeficiency_Homo sapiens_hsa053401.40425395
31Base excision repair_Homo sapiens_hsa034101.37061971
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33613170
33One carbon pool by folate_Homo sapiens_hsa006701.31719298
34Purine metabolism_Homo sapiens_hsa002301.29663715
35Pyrimidine metabolism_Homo sapiens_hsa002401.28322045
36Spliceosome_Homo sapiens_hsa030401.28203590
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24807456
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22638974
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21664591
40Olfactory transduction_Homo sapiens_hsa047401.21621223
41Peroxisome_Homo sapiens_hsa041461.19754469
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16801161
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16083935
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.14362664
45Cell cycle_Homo sapiens_hsa041101.06050101
46Taste transduction_Homo sapiens_hsa047421.03483957
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.00379972
48Linoleic acid metabolism_Homo sapiens_hsa005910.97002308
49Huntingtons disease_Homo sapiens_hsa050160.96217630
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90095144
51Systemic lupus erythematosus_Homo sapiens_hsa053220.89425362
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89035285
53Alcoholism_Homo sapiens_hsa050340.87198276
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.83121676
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82127848
56Regulation of autophagy_Homo sapiens_hsa041400.80777605
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80458673
58Alzheimers disease_Homo sapiens_hsa050100.80077345
59Oocyte meiosis_Homo sapiens_hsa041140.74025500
60mRNA surveillance pathway_Homo sapiens_hsa030150.73271249
61Fatty acid elongation_Homo sapiens_hsa000620.71453999
62Hedgehog signaling pathway_Homo sapiens_hsa043400.70269775
63Metabolic pathways_Homo sapiens_hsa011000.68097750
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.67430554
65Ribosome_Homo sapiens_hsa030100.67397084
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64901768
67Tryptophan metabolism_Homo sapiens_hsa003800.64415383
68Chemical carcinogenesis_Homo sapiens_hsa052040.63202538
69GABAergic synapse_Homo sapiens_hsa047270.62161346
70Ether lipid metabolism_Homo sapiens_hsa005650.58661726
71Arachidonic acid metabolism_Homo sapiens_hsa005900.57990110
72Retinol metabolism_Homo sapiens_hsa008300.57246763
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56520540
74Collecting duct acid secretion_Homo sapiens_hsa049660.55324454
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54794905
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53357483
77p53 signaling pathway_Homo sapiens_hsa041150.51504852
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51414185
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49544065
80Circadian entrainment_Homo sapiens_hsa047130.48143046
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47270481
82TGF-beta signaling pathway_Homo sapiens_hsa043500.45067805
83Caffeine metabolism_Homo sapiens_hsa002320.44981114
84Morphine addiction_Homo sapiens_hsa050320.44231422
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40643461
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39500029
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38613974
88Serotonergic synapse_Homo sapiens_hsa047260.37891029
89Pyruvate metabolism_Homo sapiens_hsa006200.37203391
90Circadian rhythm_Homo sapiens_hsa047100.36597670
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36277851
92ABC transporters_Homo sapiens_hsa020100.35492290
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33827147
94Basal cell carcinoma_Homo sapiens_hsa052170.32531117
95Asthma_Homo sapiens_hsa053100.31744459
96Fatty acid metabolism_Homo sapiens_hsa012120.31480440
97beta-Alanine metabolism_Homo sapiens_hsa004100.30497801
98Cardiac muscle contraction_Homo sapiens_hsa042600.29760993
99Glutathione metabolism_Homo sapiens_hsa004800.27179594
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26352374

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