ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.29564811
2	neural tube formation (GO:0001841)	5.05230289
3	protein localization to cilium (GO:0061512)	4.20538607
4	pyrimidine nucleobase catabolic process (GO:0006208)	3.94405755
5	behavioral response to ethanol (GO:0048149)	3.87308848
6	intraciliary transport (GO:0042073)	3.73357191
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.66481422
8	nonmotile primary cilium assembly (GO:0035058)	3.53372165
9	cellular ketone body metabolic process (GO:0046950)	3.47964867
10	nucleobase catabolic process (GO:0046113)	3.36422450
11	protein K11-linked deubiquitination (GO:0035871)	3.34978475
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.33229799
13	kidney morphogenesis (GO:0060993)	3.33036565
14	epithelial cilium movement (GO:0003351)	3.32822972
15	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.27388070
16	presynaptic membrane assembly (GO:0097105)	3.26920215
17	response to pheromone (GO:0019236)	3.23421303
18	fucose catabolic process (GO:0019317)	3.17524395
19	L-fucose metabolic process (GO:0042354)	3.17524395
20	L-fucose catabolic process (GO:0042355)	3.17524395
21	prenylation (GO:0097354)	3.16798507
22	protein prenylation (GO:0018342)	3.16798507
23	photoreceptor cell maintenance (GO:0045494)	3.15779409
24	ketone body metabolic process (GO:1902224)	3.15359666
25	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.15279720
26	neuronal action potential (GO:0019228)	3.08181406
27	cilium morphogenesis (GO:0060271)	3.05663382
28	DNA double-strand break processing (GO:0000729)	3.05039232
29	establishment of protein localization to Golgi (GO:0072600)	3.03978908
30	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.03404265
31	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.03404265
32	regulation of translation, ncRNA-mediated (GO:0045974)	3.03404265
33	synaptic transmission, cholinergic (GO:0007271)	3.03357130
34	transmission of nerve impulse (GO:0019226)	3.02410421
35	resolution of meiotic recombination intermediates (GO:0000712)	3.02017880
36	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.01886382
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.01173120
38	presynaptic membrane organization (GO:0097090)	3.00846966
39	regulation of cilium movement (GO:0003352)	2.99841240
40	somite rostral/caudal axis specification (GO:0032525)	2.99061592
41	cilium organization (GO:0044782)	2.99049274
42	cilium assembly (GO:0042384)	2.96940061
43	protein neddylation (GO:0045116)	2.93607587
44	regulation of hexokinase activity (GO:1903299)	2.93240230
45	regulation of glucokinase activity (GO:0033131)	2.93240230
46	cornea development in camera-type eye (GO:0061303)	2.92106700
47	detection of light stimulus involved in visual perception (GO:0050908)	2.79793309
48	detection of light stimulus involved in sensory perception (GO:0050962)	2.79793309
49	axoneme assembly (GO:0035082)	2.77499574
50	indolalkylamine metabolic process (GO:0006586)	2.77416854
51	postsynaptic membrane organization (GO:0001941)	2.76811706
52	photoreceptor cell development (GO:0042461)	2.75208877
53	protein targeting to Golgi (GO:0000042)	2.74516888
54	kynurenine metabolic process (GO:0070189)	2.73156386
55	replication fork processing (GO:0031297)	2.71171471
56	mannosylation (GO:0097502)	2.70310312
57	regulation of telomere maintenance (GO:0032204)	2.70297512
58	cilium movement (GO:0003341)	2.69804848
59	protein polyglutamylation (GO:0018095)	2.66001154
60	cilium or flagellum-dependent cell motility (GO:0001539)	2.65608593
61	respiratory chain complex IV assembly (GO:0008535)	2.61382138
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.61174313
63	retinal cone cell development (GO:0046549)	2.59971083
64	protein complex biogenesis (GO:0070271)	2.59299478
65	reflex (GO:0060004)	2.57890783
66	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.56983725
67	embryonic epithelial tube formation (GO:0001838)	2.56390817
68	indole-containing compound catabolic process (GO:0042436)	2.55389790
69	indolalkylamine catabolic process (GO:0046218)	2.55389790
70	tryptophan catabolic process (GO:0006569)	2.55389790
71	gamma-aminobutyric acid transport (GO:0015812)	2.55358086
72	synapse assembly (GO:0007416)	2.54712898
73	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.54292090
74	olfactory bulb development (GO:0021772)	2.52363648
75	eye photoreceptor cell development (GO:0042462)	2.51614378
76	signal peptide processing (GO:0006465)	2.50216356
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.50191265
78	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.50191265
79	organelle disassembly (GO:1903008)	2.48997369
80	inner ear receptor stereocilium organization (GO:0060122)	2.48577718
81	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.48162719
82	synapsis (GO:0007129)	2.47806162
83	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.45765550
84	proline transport (GO:0015824)	2.45341035
85	piRNA metabolic process (GO:0034587)	2.45218471
86	magnesium ion transport (GO:0015693)	2.45209475
87	head development (GO:0060322)	2.44626311
88	neuron cell-cell adhesion (GO:0007158)	2.42927610
89	neuronal action potential propagation (GO:0019227)	2.42685342
90	protein localization to Golgi apparatus (GO:0034067)	2.42557636
91	action potential (GO:0001508)	2.41303945
92	epithelial tube formation (GO:0072175)	2.40845724
93	startle response (GO:0001964)	2.40600619
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.40508716
95	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.40473887
96	NADH dehydrogenase complex assembly (GO:0010257)	2.40473887
97	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.40473887
98	platelet dense granule organization (GO:0060155)	2.40290256
99	auditory behavior (GO:0031223)	2.39881135
100	regulation of collateral sprouting (GO:0048670)	2.39371795

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.62733037
2	VDR_22108803_ChIP-Seq_LS180_Human	3.15925900
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.97907142
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.96111275
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.87109031
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.80796542
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.70569517
8	FUS_26573619_Chip-Seq_HEK293_Human	2.48736914
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.48214854
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.41552039
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.38862205
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31757628
13	EWS_26573619_Chip-Seq_HEK293_Human	2.28655684
14	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28333806
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.26527726
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.26216653
17	P300_19829295_ChIP-Seq_ESCs_Human	2.18910737
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.16723650
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03889863
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.90201260
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86131501
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86103592
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.81346286
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.77448507
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76825496
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.73864975
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71346051
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.70211535
29	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68661407
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68512628
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.66215220
32	STAT3_23295773_ChIP-Seq_U87_Human	1.65339533
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65096139
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62887208
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.58961834
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.58221418
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58221418
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57689052
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.57341870
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54972831
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54423157
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54423157
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53759507
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.50750398
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48221169
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47533424
47	TCF4_23295773_ChIP-Seq_U87_Human	1.47230153
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46673154
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46384114
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43875949
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43784318
52	AR_25329375_ChIP-Seq_VCAP_Human	1.43745475
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43451456
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41242631
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40908798
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.40079840
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.37291073
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36579453
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34050834
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33408253
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.32660957
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29228218
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.27946332
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27835960
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27165462
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24538371
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.23179662
68	ELK1_19687146_ChIP-ChIP_HELA_Human	1.23026398
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22286250
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22286250
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.21994349
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.19948379
73	MYC_18940864_ChIP-ChIP_HL60_Human	1.19795366
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16504246
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14503425
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14356344
77	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.13786236
78	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13144332
79	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.12627532
80	AR_21572438_ChIP-Seq_LNCaP_Human	1.11904000
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11854754
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10232414
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08385474
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08147616
85	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08103086
86	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07664975
87	P300_18555785_Chip-Seq_ESCs_Mouse	1.07346944
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07250657
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07014739
90	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05879998
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.05451337
92	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04872036
93	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03315479
94	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.03176871
95	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.02864801
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02597168
97	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.00239169
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99432026
99	NCOR_22424771_ChIP-Seq_293T_Human	0.99290600
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99267276

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.28239588
2	MP0000569_abnormal_digit_pigmentation	3.06769216
3	MP0003787_abnormal_imprinting	2.98704412
4	MP0006292_abnormal_olfactory_placode	2.76994997
5	MP0003880_abnormal_central_pattern	2.72632141
6	MP0001984_abnormal_olfaction	2.47393722
7	MP0002102_abnormal_ear_morphology	2.41194915
8	MP0006276_abnormal_autonomic_nervous	2.32793522
9	MP0006072_abnormal_retinal_apoptosis	2.31005479
10	MP0003122_maternal_imprinting	2.27728953
11	MP0003121_genomic_imprinting	2.25281501
12	MP0003890_abnormal_embryonic-extraembry	2.24779752
13	MP0002638_abnormal_pupillary_reflex	2.13921699
14	MP0005551_abnormal_eye_electrophysiolog	2.13030126
15	MP0009046_muscle_twitch	2.09386384
16	MP0005253_abnormal_eye_physiology	1.99067648
17	MP0001529_abnormal_vocalization	1.97650557
18	MP0008057_abnormal_DNA_replication	1.86647840
19	MP0009745_abnormal_behavioral_response	1.85320228
20	MP0000778_abnormal_nervous_system	1.84483474
21	MP0001968_abnormal_touch/_nociception	1.84399448
22	MP0008789_abnormal_olfactory_epithelium	1.83759846
23	MP0004147_increased_porphyrin_level	1.77242977
24	MP0000427_abnormal_hair_cycle	1.76481780
25	MP0005499_abnormal_olfactory_system	1.74769112
26	MP0005394_taste/olfaction_phenotype	1.74769112
27	MP0002938_white_spotting	1.68143404
28	MP0004142_abnormal_muscle_tone	1.65815221
29	MP0002653_abnormal_ependyma_morphology	1.63936377
30	MP0002272_abnormal_nervous_system	1.63094608
31	MP0001486_abnormal_startle_reflex	1.61612977
32	MP0002736_abnormal_nociception_after	1.60041844
33	MP0003195_calcinosis	1.57777211
34	MP0004133_heterotaxia	1.57353849
35	MP0000372_irregular_coat_pigmentation	1.56132908
36	MP0004043_abnormal_pH_regulation	1.54481381
37	MP0001188_hyperpigmentation	1.53481608
38	MP0004742_abnormal_vestibular_system	1.51325380
39	MP0005645_abnormal_hypothalamus_physiol	1.51071698
40	MP0001485_abnormal_pinna_reflex	1.48994705
41	MP0005423_abnormal_somatic_nervous	1.48708476
42	MP0000631_abnormal_neuroendocrine_gland	1.47601767
43	MP0003635_abnormal_synaptic_transmissio	1.46203314
44	MP0002184_abnormal_innervation	1.39937971
45	MP0002822_catalepsy	1.39337862
46	MP0002572_abnormal_emotion/affect_behav	1.37778102
47	MP0002557_abnormal_social/conspecific_i	1.37704067
48	MP0005646_abnormal_pituitary_gland	1.34467179
49	MP0002735_abnormal_chemical_nociception	1.32579742
50	MP0002067_abnormal_sensory_capabilities	1.31128479
51	MP0001986_abnormal_taste_sensitivity	1.30330353
52	MP0004924_abnormal_behavior	1.26267385
53	MP0005386_behavior/neurological_phenoty	1.26267385
54	MP0002064_seizures	1.22871518
55	MP0002160_abnormal_reproductive_system	1.22771732
56	MP0002752_abnormal_somatic_nervous	1.22536821
57	MP0002063_abnormal_learning/memory/cond	1.21109868
58	MP0004885_abnormal_endolymph	1.20924163
59	MP0005195_abnormal_posterior_eye	1.20579023
60	MP0003646_muscle_fatigue	1.19047704
61	MP0002837_dystrophic_cardiac_calcinosis	1.18631168
62	MP0003011_delayed_dark_adaptation	1.17332397
63	MP0002751_abnormal_autonomic_nervous	1.16483284
64	MP0002909_abnormal_adrenal_gland	1.16356233
65	MP0002734_abnormal_mechanical_nocicepti	1.15970470
66	MP0008872_abnormal_physiological_respon	1.14537698
67	MP0000383_abnormal_hair_follicle	1.14032480
68	MP0001970_abnormal_pain_threshold	1.13885048
69	MP0002876_abnormal_thyroid_physiology	1.12856677
70	MP0010386_abnormal_urinary_bladder	1.10318639
71	MP0002928_abnormal_bile_duct	1.09139503
72	MP0000955_abnormal_spinal_cord	1.02227378
73	MP0001293_anophthalmia	1.00534441
74	MP0002733_abnormal_thermal_nociception	1.00341703
75	MP0001501_abnormal_sleep_pattern	0.99161170
76	MP0004145_abnormal_muscle_electrophysio	0.98193445
77	MP0002882_abnormal_neuron_morphology	0.97950717
78	MP0005391_vision/eye_phenotype	0.97211705
79	MP0005389_reproductive_system_phenotype	0.97114677
80	MP0002254_reproductive_system_inflammat	0.95667268
81	MP0003123_paternal_imprinting	0.94877840
82	MP0003136_yellow_coat_color	0.94050716
83	MP0002229_neurodegeneration	0.92255086
84	MP0001324_abnormal_eye_pigmentation	0.90305783
85	MP0004270_analgesia	0.89402080
86	MP0002234_abnormal_pharynx_morphology	0.89314174
87	MP0003119_abnormal_digestive_system	0.87957783
88	MP0000647_abnormal_sebaceous_gland	0.87848361
89	MP0000026_abnormal_inner_ear	0.87615777
90	MP0002090_abnormal_vision	0.87163007
91	MP0001963_abnormal_hearing_physiology	0.85242179
92	MP0008995_early_reproductive_senescence	0.84927212
93	MP0001919_abnormal_reproductive_system	0.84897439
94	MP0002163_abnormal_gland_morphology	0.84643521
95	MP0004215_abnormal_myocardial_fiber	0.84492289
96	MP0001440_abnormal_grooming_behavior	0.83998843
97	MP0003937_abnormal_limbs/digits/tail_de	0.83366759
98	MP0004859_abnormal_synaptic_plasticity	0.82969956
99	MP0005174_abnormal_tail_pigmentation	0.81999623
100	MP0008058_abnormal_DNA_repair	0.81835408

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.08404324
2	Pancreatic fibrosis (HP:0100732)	4.06821037
3	True hermaphroditism (HP:0010459)	3.60753552
4	Nephronophthisis (HP:0000090)	3.55036787
5	Molar tooth sign on MRI (HP:0002419)	3.47456608
6	Abnormality of midbrain morphology (HP:0002418)	3.47456608
7	Medial flaring of the eyebrow (HP:0010747)	3.30265177
8	Congenital stationary night blindness (HP:0007642)	3.28669211
9	Abnormality of the renal medulla (HP:0100957)	3.09009081
10	Gait imbalance (HP:0002141)	3.02687826
11	Decreased central vision (HP:0007663)	2.97739470
12	Abnormality of the renal cortex (HP:0011035)	2.95549405
13	Type II lissencephaly (HP:0007260)	2.94745378
14	Chronic hepatic failure (HP:0100626)	2.86888691
15	Congenital primary aphakia (HP:0007707)	2.84173345
16	Febrile seizures (HP:0002373)	2.80649121
17	Hyperventilation (HP:0002883)	2.79452663
18	Renal cortical cysts (HP:0000803)	2.68501902
19	Colon cancer (HP:0003003)	2.63772320
20	Attenuation of retinal blood vessels (HP:0007843)	2.62652031
21	Nephrogenic diabetes insipidus (HP:0009806)	2.59654918
22	Cystic liver disease (HP:0006706)	2.59511246
23	Abolished electroretinogram (ERG) (HP:0000550)	2.55082869
24	Genital tract atresia (HP:0001827)	2.49040767
25	Vaginal atresia (HP:0000148)	2.45024025
26	Lipid accumulation in hepatocytes (HP:0006561)	2.44810212
27	Pendular nystagmus (HP:0012043)	2.35035605
28	Lissencephaly (HP:0001339)	2.33842199
29	Progressive cerebellar ataxia (HP:0002073)	2.33770556
30	Retinal dysplasia (HP:0007973)	2.31502213
31	Abnormality of the labia minora (HP:0012880)	2.30947004
32	Pachygyria (HP:0001302)	2.30646866
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.30359955
34	Gaze-evoked nystagmus (HP:0000640)	2.29800574
35	Intestinal atresia (HP:0011100)	2.28798918
36	Genetic anticipation (HP:0003743)	2.27831645
37	Inability to walk (HP:0002540)	2.27115042
38	Polyphagia (HP:0002591)	2.25568902
39	Methylmalonic acidemia (HP:0002912)	2.24034801
40	Poor coordination (HP:0002370)	2.23151817
41	Drooling (HP:0002307)	2.22690113
42	Hypothermia (HP:0002045)	2.19328024
43	Broad-based gait (HP:0002136)	2.18908265
44	Progressive inability to walk (HP:0002505)	2.18820953
45	Increased hepatocellular lipid droplets (HP:0006565)	2.17125745
46	Sclerocornea (HP:0000647)	2.15113940
47	Anencephaly (HP:0002323)	2.12540498
48	Absent speech (HP:0001344)	2.12115447
49	Congenital hepatic fibrosis (HP:0002612)	2.09958739
50	Postaxial foot polydactyly (HP:0001830)	2.09818158
51	Atonic seizures (HP:0010819)	2.08325552
52	Tubulointerstitial nephritis (HP:0001970)	2.07604318
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.06132168
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.05932325
55	Dialeptic seizures (HP:0011146)	2.04381712
56	Focal seizures (HP:0007359)	2.03282188
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.01334348
58	Postaxial hand polydactyly (HP:0001162)	2.00318949
59	Protruding tongue (HP:0010808)	2.00276348
60	Rib fusion (HP:0000902)	1.98946765
61	Limb dystonia (HP:0002451)	1.98767153
62	Optic nerve hypoplasia (HP:0000609)	1.98290240
63	Excessive salivation (HP:0003781)	1.97238774
64	Oligodactyly (hands) (HP:0001180)	1.96043392
65	Narrow forehead (HP:0000341)	1.93083173
66	Tubular atrophy (HP:0000092)	1.92228723
67	Bile duct proliferation (HP:0001408)	1.91233405
68	Abnormal biliary tract physiology (HP:0012439)	1.91233405
69	Focal motor seizures (HP:0011153)	1.90552255
70	Male pseudohermaphroditism (HP:0000037)	1.89744821
71	Astigmatism (HP:0000483)	1.86513604
72	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85769000
73	Specific learning disability (HP:0001328)	1.85530390
74	Mitochondrial inheritance (HP:0001427)	1.85410049
75	Agitation (HP:0000713)	1.84325817
76	Acute necrotizing encephalopathy (HP:0006965)	1.83542376
77	Abnormal drinking behavior (HP:0030082)	1.82086404
78	Polydipsia (HP:0001959)	1.82086404
79	Cerebellar dysplasia (HP:0007033)	1.80611549
80	Occipital encephalocele (HP:0002085)	1.79351921
81	Increased CSF lactate (HP:0002490)	1.79238494
82	Methylmalonic aciduria (HP:0012120)	1.78468802
83	Progressive macrocephaly (HP:0004481)	1.77585257
84	Dyskinesia (HP:0100660)	1.77183365
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76738354
86	Keratoconus (HP:0000563)	1.76380794
87	Increased corneal curvature (HP:0100692)	1.76380794
88	Hypoplasia of the pons (HP:0012110)	1.75371019
89	Dandy-Walker malformation (HP:0001305)	1.73737726
90	Abnormality of the pons (HP:0007361)	1.73469087
91	Hyperglycinemia (HP:0002154)	1.71931443
92	Tubulointerstitial abnormality (HP:0001969)	1.71224725
93	Furrowed tongue (HP:0000221)	1.70651794
94	Thyroiditis (HP:0100646)	1.68997736
95	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.68672083
96	Growth hormone deficiency (HP:0000824)	1.67401565
97	Absence seizures (HP:0002121)	1.67142396
98	Widely spaced teeth (HP:0000687)	1.67036918
99	Neoplasm of the adrenal cortex (HP:0100641)	1.65828982
100	Fair hair (HP:0002286)	1.64490686

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.30693651
2	MAP3K4	2.98535142
3	BMPR1B	2.95617638
4	WNK3	2.78423024
5	NUAK1	2.53615886
6	MAP4K2	2.44479965
7	CASK	2.35727299
8	TNIK	2.34430757
9	TRIM28	2.30465330
10	ACVR1B	2.27073520
11	ADRBK2	2.16962431
12	MAPK13	2.03814695
13	MARK1	2.03434110
14	BCR	1.95413157
15	WNK4	1.76640667
16	MAP2K7	1.71451888
17	ZAK	1.69250536
18	GRK1	1.66142069
19	PINK1	1.64267541
20	LATS1	1.62875455
21	ERBB3	1.52397272
22	PAK3	1.52373682
23	CAMKK2	1.45725376
24	MKNK2	1.42013560
25	FGFR2	1.41650123
26	INSRR	1.36921971
27	DYRK3	1.31407175
28	AKT3	1.25247433
29	OXSR1	1.24910261
30	DYRK2	1.24481582
31	STK39	1.20079174
32	STK38L	1.07008056
33	CAMK1D	1.04515498
34	STK3	1.04039593
35	PLK2	1.02723274
36	TAF1	1.01859601
37	SIK2	0.99708502
38	PRKCE	0.95589919
39	MKNK1	0.93322012
40	CSNK1G2	0.93255248
41	TAOK3	0.92848447
42	TGFBR1	0.88351234
43	IRAK1	0.87846456
44	EPHA3	0.86833086
45	PIK3CA	0.86255039
46	NTRK2	0.85642445
47	NTRK3	0.85494239
48	PRKCG	0.83895561
49	TXK	0.79959958
50	DYRK1A	0.79282191
51	ADRBK1	0.79279739
52	TLK1	0.75290731
53	EPHA4	0.74595218
54	CDC7	0.74337226
55	SGK2	0.74018154
56	CSNK1G1	0.71338650
57	CSNK1A1L	0.71235411
58	CAMK1G	0.69919663
59	TIE1	0.68233112
60	DAPK2	0.68218439
61	VRK1	0.67617843
62	MAPK15	0.66911903
63	MINK1	0.64456591
64	CSNK1G3	0.63758554
65	BCKDK	0.63119955
66	PLK3	0.61407440
67	NLK	0.58681970
68	SGK223	0.58450418
69	SGK494	0.58450418
70	MAP2K4	0.57528761
71	CAMK4	0.56921111
72	CAMK2A	0.54262184
73	SIK3	0.53753526
74	WNK1	0.53746299
75	FER	0.53610237
76	PLK4	0.53136423
77	PTK2B	0.50865707
78	PHKG1	0.49668034
79	PHKG2	0.49668034
80	STK11	0.48428828
81	BRSK2	0.43496276
82	CAMK1	0.41703528
83	MAP3K9	0.40958124
84	PRKACA	0.40626424
85	MST4	0.40593348
86	STK16	0.40414222
87	PRKAA1	0.40027119
88	PNCK	0.40019197
89	PRKCQ	0.39510810
90	TEC	0.38954164
91	PRKG1	0.38360751
92	CSNK1D	0.38353268
93	PRKAA2	0.35675400
94	OBSCN	0.35530093
95	STK24	0.33373977
96	ATM	0.32805503
97	CSNK1A1	0.32744362
98	CSNK1E	0.32247919
99	PRKACB	0.31871747
100	CHUK	0.31732708

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.42341335
2	Nicotine addiction_Homo sapiens_hsa05033	3.38965416
3	Protein export_Homo sapiens_hsa03060	2.50846734
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.32535262
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29818949
6	Butanoate metabolism_Homo sapiens_hsa00650	2.29267696
7	Phototransduction_Homo sapiens_hsa04744	2.26264009
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.20652521
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.12080453
10	Basal transcription factors_Homo sapiens_hsa03022	2.08100454
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.91977213
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87244699
13	GABAergic synapse_Homo sapiens_hsa04727	1.84181963
14	Morphine addiction_Homo sapiens_hsa05032	1.82128840
15	Taste transduction_Homo sapiens_hsa04742	1.80357856
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.76112344
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.74934111
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72297543
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.70840324
20	Homologous recombination_Homo sapiens_hsa03440	1.70358960
21	Parkinsons disease_Homo sapiens_hsa05012	1.68851874
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.66901908
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65324029
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.64870171
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.60710174
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.58617106
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.57691079
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.52414124
29	Propanoate metabolism_Homo sapiens_hsa00640	1.50350763
30	RNA degradation_Homo sapiens_hsa03018	1.39174986
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.35534473
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.33497000
33	RNA polymerase_Homo sapiens_hsa03020	1.31827036
34	Circadian entrainment_Homo sapiens_hsa04713	1.30845766
35	Serotonergic synapse_Homo sapiens_hsa04726	1.29967610
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.28251996
37	Huntingtons disease_Homo sapiens_hsa05016	1.22164453
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.20622580
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19162663
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15405849
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.15077658
42	Steroid biosynthesis_Homo sapiens_hsa00100	1.11647257
43	Alzheimers disease_Homo sapiens_hsa05010	1.10764288
44	Insulin secretion_Homo sapiens_hsa04911	1.06014788
45	Dopaminergic synapse_Homo sapiens_hsa04728	1.05921677
46	Peroxisome_Homo sapiens_hsa04146	1.05248365
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03313027
48	Non-homologous end-joining_Homo sapiens_hsa03450	1.03220060
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97691598
50	Regulation of autophagy_Homo sapiens_hsa04140	0.97394130
51	Olfactory transduction_Homo sapiens_hsa04740	0.96354197
52	ABC transporters_Homo sapiens_hsa02010	0.92305794
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.91552495
54	Cholinergic synapse_Homo sapiens_hsa04725	0.85942731
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84676715
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76677996
57	Caffeine metabolism_Homo sapiens_hsa00232	0.76593926
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74748160
59	Fatty acid elongation_Homo sapiens_hsa00062	0.74595396
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.74149053
61	Cocaine addiction_Homo sapiens_hsa05030	0.72134402
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.67136892
63	Long-term depression_Homo sapiens_hsa04730	0.66586439
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.66054355
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.64827495
66	Retinol metabolism_Homo sapiens_hsa00830	0.63780641
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60378700
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58311513
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57004019
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56682767
71	Amphetamine addiction_Homo sapiens_hsa05031	0.56511250
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.55740510
73	Axon guidance_Homo sapiens_hsa04360	0.55483709
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.53965721
75	Circadian rhythm_Homo sapiens_hsa04710	0.53496817
76	Metabolic pathways_Homo sapiens_hsa01100	0.52947510
77	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.52753276
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51136359
79	Fatty acid degradation_Homo sapiens_hsa00071	0.49918039
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.49887681
81	Salivary secretion_Homo sapiens_hsa04970	0.49515643
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49510898
83	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47463620
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45738510
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.44709612
86	Histidine metabolism_Homo sapiens_hsa00340	0.44375439
87	Sulfur metabolism_Homo sapiens_hsa00920	0.44204439
88	Purine metabolism_Homo sapiens_hsa00230	0.43810291
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42450352
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.38168990
91	RNA transport_Homo sapiens_hsa03013	0.36890444
92	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36679008
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36256966
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35844655
95	One carbon pool by folate_Homo sapiens_hsa00670	0.35354091
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35294657
97	Mismatch repair_Homo sapiens_hsa03430	0.35162297
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.33975968
99	Mineral absorption_Homo sapiens_hsa04978	0.31821183
100	Ras signaling pathway_Homo sapiens_hsa04014	0.31641286

ZNF720

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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