ZNF721

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.95420728
2DNA replication checkpoint (GO:0000076)4.39798332
3regulation of mitotic spindle checkpoint (GO:1903504)4.09469745
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.09469745
5regulation of DNA endoreduplication (GO:0032875)4.09355470
6chromatin remodeling at centromere (GO:0031055)4.04104974
7CENP-A containing nucleosome assembly (GO:0034080)3.97895719
8negative regulation of DNA-dependent DNA replication (GO:2000104)3.83849170
9regulation of nuclear cell cycle DNA replication (GO:0033262)3.65829630
10DNA catabolic process, exonucleolytic (GO:0000738)3.60122671
11regulation of centriole replication (GO:0046599)3.53087874
12histone exchange (GO:0043486)3.51204764
13replication fork processing (GO:0031297)3.49778203
14kinetochore organization (GO:0051383)3.45428534
15mitotic sister chromatid cohesion (GO:0007064)3.38573476
16postreplication repair (GO:0006301)3.21931928
17negative regulation of DNA recombination (GO:0045910)3.19622602
18kinetochore assembly (GO:0051382)3.16112532
19DNA replication-independent nucleosome organization (GO:0034724)3.12798627
20DNA replication-independent nucleosome assembly (GO:0006336)3.12798627
21histone H2A acetylation (GO:0043968)3.12315096
22centriole replication (GO:0007099)3.11219215
23respiratory chain complex IV assembly (GO:0008535)3.02935237
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02522221
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.02522221
26mitochondrial DNA replication (GO:0006264)2.95606673
27microtubule depolymerization (GO:0007019)2.95460585
28pre-miRNA processing (GO:0031054)2.94943320
29maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94901406
30atrial cardiac muscle cell action potential (GO:0086014)2.92639984
31spindle checkpoint (GO:0031577)2.92022526
32protein localization to kinetochore (GO:0034501)2.90655061
33mitotic spindle checkpoint (GO:0071174)2.89888592
34RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89212171
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88096513
36negative regulation of translation, ncRNA-mediated (GO:0040033)2.88096513
37regulation of translation, ncRNA-mediated (GO:0045974)2.88096513
38negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86391505
39negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86391505
40negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86391505
41negative regulation of mitotic sister chromatid separation (GO:2000816)2.86391505
42negative regulation of sister chromatid segregation (GO:0033046)2.86391505
43translesion synthesis (GO:0019985)2.84377778
44recombinational repair (GO:0000725)2.82556025
45regulation of helicase activity (GO:0051095)2.81565702
46regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80914482
47regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80914482
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80434441
49double-strand break repair via homologous recombination (GO:0000724)2.79816982
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77899729
51negative regulation of chromosome segregation (GO:0051985)2.76472506
52histone mRNA metabolic process (GO:0008334)2.74835121
53regulation of mitotic sister chromatid separation (GO:0010965)2.74654306
54regulation of mitotic sister chromatid segregation (GO:0033047)2.74654306
55regulation of sister chromatid segregation (GO:0033045)2.74654306
56DNA replication-dependent nucleosome organization (GO:0034723)2.74628168
57DNA replication-dependent nucleosome assembly (GO:0006335)2.74628168
58double-strand break repair via nonhomologous end joining (GO:0006303)2.74328684
59non-recombinational repair (GO:0000726)2.74328684
60mitotic metaphase plate congression (GO:0007080)2.73655419
61metaphase plate congression (GO:0051310)2.73289030
62intra-S DNA damage checkpoint (GO:0031573)2.72549453
63synapsis (GO:0007129)2.72141190
64regulation of meiosis I (GO:0060631)2.66737794
65negative regulation of transcription regulatory region DNA binding (GO:2000678)2.65971452
66regulation of centrosome cycle (GO:0046605)2.65879564
67positive regulation of histone H3-K4 methylation (GO:0051571)2.64443170
68presynaptic membrane assembly (GO:0097105)2.64009669
69spliceosomal snRNP assembly (GO:0000387)2.62583032
70retinal cone cell development (GO:0046549)2.61219325
71monoubiquitinated protein deubiquitination (GO:0035520)2.59718631
72neural tube formation (GO:0001841)2.58277841
73mitotic spindle assembly checkpoint (GO:0007094)2.57941388
74telomere maintenance via telomerase (GO:0007004)2.57488086
75spindle assembly checkpoint (GO:0071173)2.56858703
76regulation of DNA methylation (GO:0044030)2.56162726
77microtubule polymerization or depolymerization (GO:0031109)2.56069958
78attachment of spindle microtubules to kinetochore (GO:0008608)2.55442229
79somite development (GO:0061053)2.52988792
80regulation of centrosome duplication (GO:0010824)2.52680048
81DNA-dependent DNA replication (GO:0006261)2.51996596
82presynaptic membrane organization (GO:0097090)2.50330407
83resolution of meiotic recombination intermediates (GO:0000712)2.49492164
84telomere maintenance via semi-conservative replication (GO:0032201)2.48402635
85DNA strand elongation involved in DNA replication (GO:0006271)2.47975092
86regulation of double-strand break repair via homologous recombination (GO:0010569)2.46258488
87mitotic recombination (GO:0006312)2.45941405
88intraciliary transport (GO:0042073)2.45414875
89telomere maintenance via recombination (GO:0000722)2.44320430
90mitochondrial RNA metabolic process (GO:0000959)2.44118785
91sister chromatid cohesion (GO:0007062)2.44021515
92positive regulation of mRNA processing (GO:0050685)2.43220132
93protein K11-linked deubiquitination (GO:0035871)2.42434243
94protein localization to chromosome, centromeric region (GO:0071459)2.40696878
95regulation of chromosome segregation (GO:0051983)2.40386505
96DNA ligation (GO:0006266)2.39942737
97ATP-dependent chromatin remodeling (GO:0043044)2.39507023
98DNA damage response, detection of DNA damage (GO:0042769)2.39069952
99lactate metabolic process (GO:0006089)2.38876797
100negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.38263455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.86390128
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.54133519
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03243580
4* ZNF274_21170338_ChIP-Seq_K562_Hela2.80076362
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78399200
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.56386774
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54542689
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54541820
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53976579
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.50985369
11EWS_26573619_Chip-Seq_HEK293_Human2.47652518
12FUS_26573619_Chip-Seq_HEK293_Human2.46714962
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40105001
14IGF1R_20145208_ChIP-Seq_DFB_Human2.38094058
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29667991
16TAF15_26573619_Chip-Seq_HEK293_Human2.24964090
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18260722
18ELK1_19687146_ChIP-ChIP_HELA_Human2.10634823
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04329773
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04163267
21GBX2_23144817_ChIP-Seq_PC3_Human2.03377239
22VDR_22108803_ChIP-Seq_LS180_Human2.02014018
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99798116
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.97968564
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91245437
26P300_19829295_ChIP-Seq_ESCs_Human1.89017603
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86861665
28* VDR_23849224_ChIP-Seq_CD4+_Human1.74616615
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74476524
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73722531
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71577519
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.68371277
33* NOTCH1_21737748_ChIP-Seq_TLL_Human1.66993691
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61030906
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60017105
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59694906
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56931381
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56257793
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54498329
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50014888
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47637526
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46268277
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44203263
44MYC_18940864_ChIP-ChIP_HL60_Human1.44036584
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.41686316
46FOXP3_21729870_ChIP-Seq_TREG_Human1.39898404
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38392943
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33408430
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30677665
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30546624
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27931102
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.25895842
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25154991
54SMAD4_21799915_ChIP-Seq_A2780_Human1.24769845
55IRF1_19129219_ChIP-ChIP_H3396_Human1.24473281
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.23740309
57ER_23166858_ChIP-Seq_MCF-7_Human1.23379900
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.22500599
59CBP_20019798_ChIP-Seq_JUKART_Human1.22462556
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22462556
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17463898
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17463898
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.17348405
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17225798
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15819605
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.15607640
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14127166
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13896339
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13728923
70STAT3_23295773_ChIP-Seq_U87_Human1.13585360
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.13371126
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.12872443
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12751114
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.12484277
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12415847
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10629710
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08994572
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.08487464
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07221295
80TCF4_23295773_ChIP-Seq_U87_Human1.06831804
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.06158813
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05821910
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05518344
84AR_21909140_ChIP-Seq_LNCAP_Human1.05301003
85BCAT_22108803_ChIP-Seq_LS180_Human1.04497489
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04252883
87TP53_22573176_ChIP-Seq_HFKS_Human1.03138061
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02954382
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02949135
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02607585
91RNF2_27304074_Chip-Seq_NSC_Mouse1.01395366
92AR_25329375_ChIP-Seq_VCAP_Human0.98526136
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97089419
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96137514
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95968466
96MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95712884
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94934704
98RUNX2_22187159_ChIP-Seq_PCA_Human0.94479770
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94473200
100TCF4_22108803_ChIP-Seq_LS180_Human0.93594829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.00459736
2MP0006292_abnormal_olfactory_placode3.42695868
3MP0008877_abnormal_DNA_methylation3.20302058
4MP0008058_abnormal_DNA_repair2.92711117
5MP0002102_abnormal_ear_morphology2.84998599
6MP0010094_abnormal_chromosome_stability2.75585915
7MP0003693_abnormal_embryo_hatching2.20214381
8MP0003890_abnormal_embryonic-extraembry2.17603400
9MP0003136_yellow_coat_color2.08609003
10MP0008789_abnormal_olfactory_epithelium2.01951422
11MP0003718_maternal_effect1.95249814
12MP0003787_abnormal_imprinting1.92268150
13MP0000372_irregular_coat_pigmentation1.91293144
14MP0005394_taste/olfaction_phenotype1.90697421
15MP0005499_abnormal_olfactory_system1.90697421
16MP0004957_abnormal_blastocyst_morpholog1.90596499
17MP0003111_abnormal_nucleus_morphology1.85154800
18MP0003880_abnormal_central_pattern1.81235602
19MP0003077_abnormal_cell_cycle1.76531327
20MP0006072_abnormal_retinal_apoptosis1.74264273
21MP0001293_anophthalmia1.71744862
22MP0002234_abnormal_pharynx_morphology1.70932278
23MP0000569_abnormal_digit_pigmentation1.69362737
24MP0001984_abnormal_olfaction1.60265713
25MP0003121_genomic_imprinting1.58337735
26MP0001529_abnormal_vocalization1.57252812
27MP0000631_abnormal_neuroendocrine_gland1.53293777
28MP0008932_abnormal_embryonic_tissue1.53053552
29MP0008995_early_reproductive_senescence1.50310501
30MP0003567_abnormal_fetal_cardiomyocyte1.49864621
31MP0005253_abnormal_eye_physiology1.49658531
32MP0001188_hyperpigmentation1.48108873
33MP0000778_abnormal_nervous_system1.47124238
34MP0002938_white_spotting1.37138867
35MP0003937_abnormal_limbs/digits/tail_de1.34640723
36MP0004133_heterotaxia1.32147170
37MP0009046_muscle_twitch1.28769782
38MP0003119_abnormal_digestive_system1.27230903
39MP0002837_dystrophic_cardiac_calcinosis1.25745814
40MP0005551_abnormal_eye_electrophysiolog1.25588700
41MP0002751_abnormal_autonomic_nervous1.24651592
42MP0005645_abnormal_hypothalamus_physiol1.20080217
43MP0003786_premature_aging1.17136884
44MP0001929_abnormal_gametogenesis1.13951650
45MP0001286_abnormal_eye_development1.13877084
46MP0004197_abnormal_fetal_growth/weight/1.12007459
47MP0003646_muscle_fatigue1.11729706
48MP0001486_abnormal_startle_reflex1.11597466
49MP0003941_abnormal_skin_development1.11588210
50MP0002163_abnormal_gland_morphology1.09335762
51MP0005391_vision/eye_phenotype1.08712286
52MP0002233_abnormal_nose_morphology1.08636970
53MP0000647_abnormal_sebaceous_gland1.07617523
54MP0000049_abnormal_middle_ear1.06123229
55MP0002210_abnormal_sex_determination1.05571991
56MP0002638_abnormal_pupillary_reflex1.02371251
57MP0003137_abnormal_impulse_conducting1.02340043
58MP0004142_abnormal_muscle_tone1.02253352
59MP0003938_abnormal_ear_development1.02172672
60MP0002272_abnormal_nervous_system1.01009429
61MP0003122_maternal_imprinting0.99632838
62MP0002736_abnormal_nociception_after0.99502583
63MP0008007_abnormal_cellular_replicative0.99321957
64MP0005248_abnormal_Harderian_gland0.98611276
65MP0002084_abnormal_developmental_patter0.95159928
66MP0003195_calcinosis0.95033871
67MP0001177_atelectasis0.94791810
68MP0001145_abnormal_male_reproductive0.93906084
69MP0000653_abnormal_sex_gland0.93140695
70MP0005187_abnormal_penis_morphology0.92801228
71MP0006035_abnormal_mitochondrial_morpho0.91996422
72MP0009703_decreased_birth_body0.91819605
73MP0005075_abnormal_melanosome_morpholog0.91424192
74MP0002090_abnormal_vision0.90964316
75MP0005367_renal/urinary_system_phenotyp0.90024651
76MP0000516_abnormal_urinary_system0.90024651
77MP0003698_abnormal_male_reproductive0.89507498
78MP0002095_abnormal_skin_pigmentation0.87874035
79MP0003861_abnormal_nervous_system0.86403134
80MP0009745_abnormal_behavioral_response0.85952616
81MP0006276_abnormal_autonomic_nervous0.84645671
82MP0001485_abnormal_pinna_reflex0.84438230
83MP0002557_abnormal_social/conspecific_i0.83324201
84MP0004885_abnormal_endolymph0.81954032
85MP0005646_abnormal_pituitary_gland0.81738766
86MP0002160_abnormal_reproductive_system0.81227838
87MP0000427_abnormal_hair_cycle0.80459025
88MP0004270_analgesia0.80185815
89MP0001697_abnormal_embryo_size0.80044529
90MP0005084_abnormal_gallbladder_morpholo0.79835709
91MP0002184_abnormal_innervation0.78572121
92MP0003755_abnormal_palate_morphology0.78569897
93MP0001324_abnormal_eye_pigmentation0.77347355
94MP0002111_abnormal_tail_morphology0.76911668
95MP0004215_abnormal_myocardial_fiber0.75911500
96MP0002085_abnormal_embryonic_tissue0.75607736
97MP0002752_abnormal_somatic_nervous0.75284238
98MP0001968_abnormal_touch/_nociception0.74349961
99MP0004924_abnormal_behavior0.73758908
100MP0005386_behavior/neurological_phenoty0.73758908

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.59549015
2Colon cancer (HP:0003003)3.03193732
3Abnormality of chromosome stability (HP:0003220)2.88718970
4Meckel diverticulum (HP:0002245)2.77758632
5Ectopic kidney (HP:0000086)2.76894157
6Aplasia/Hypoplasia of the uvula (HP:0010293)2.75401570
7Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71559129
8Chromsome breakage (HP:0040012)2.71504364
9Neoplasm of the adrenal cortex (HP:0100641)2.69587811
10Abnormality of the ileum (HP:0001549)2.67669789
11Volvulus (HP:0002580)2.65539880
12Abnormality of midbrain morphology (HP:0002418)2.54488693
13Molar tooth sign on MRI (HP:0002419)2.54488693
14Intestinal atresia (HP:0011100)2.54275222
15Pancreatic fibrosis (HP:0100732)2.50911585
16Medial flaring of the eyebrow (HP:0010747)2.47166823
17Pancreatic cysts (HP:0001737)2.44661526
18Septo-optic dysplasia (HP:0100842)2.37984326
19Embryonal renal neoplasm (HP:0011794)2.37472239
20Nephronophthisis (HP:0000090)2.34935555
21True hermaphroditism (HP:0010459)2.32276340
22Drooling (HP:0002307)2.31660268
23Hepatoblastoma (HP:0002884)2.31580569
24Nephroblastoma (Wilms tumor) (HP:0002667)2.29655645
25Methylmalonic acidemia (HP:0002912)2.29464587
26Abnormality of the preputium (HP:0100587)2.28232805
27Oligodactyly (hands) (HP:0001180)2.27558620
28Congenital primary aphakia (HP:0007707)2.25281884
29Gait imbalance (HP:0002141)2.23544042
30Genital tract atresia (HP:0001827)2.19107147
31Sloping forehead (HP:0000340)2.16294907
32Nephrogenic diabetes insipidus (HP:0009806)2.16263866
33Medulloblastoma (HP:0002885)2.11241028
34Abnormal lung lobation (HP:0002101)2.09638248
35Neoplasm of the adrenal gland (HP:0100631)2.09539955
36Chronic hepatic failure (HP:0100626)2.08662844
37Abnormal hair whorl (HP:0010721)2.08330300
38Abnormality of the duodenum (HP:0002246)2.07835991
39Duodenal stenosis (HP:0100867)2.07303098
40Small intestinal stenosis (HP:0012848)2.07303098
41Vaginal atresia (HP:0000148)2.07216862
42Excessive salivation (HP:0003781)2.07144221
43Optic nerve hypoplasia (HP:0000609)2.02162056
44Poor coordination (HP:0002370)2.01980158
45Abnormality of the renal medulla (HP:0100957)2.01462220
46Bifid tongue (HP:0010297)2.00983540
47Tubulointerstitial nephritis (HP:0001970)1.99987269
48Supernumerary spleens (HP:0009799)1.97768711
49Birth length less than 3rd percentile (HP:0003561)1.96714962
50Glioma (HP:0009733)1.94361550
51Aplasia/Hypoplasia of the tibia (HP:0005772)1.93057646
52Gastrointestinal atresia (HP:0002589)1.92173793
53Abnormality of the pons (HP:0007361)1.91261612
54Abnormality of the septum pellucidum (HP:0007375)1.90308229
55Triphalangeal thumb (HP:0001199)1.89664002
56Abnormality of vitamin B metabolism (HP:0004340)1.89053395
57Biliary tract neoplasm (HP:0100574)1.86557589
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86178087
59Aplasia/Hypoplasia of the sternum (HP:0006714)1.85346193
60Aqueductal stenosis (HP:0002410)1.83249319
61Preaxial hand polydactyly (HP:0001177)1.81212040
62Increased hepatocellular lipid droplets (HP:0006565)1.80671973
63Hypoplasia of the pons (HP:0012110)1.80144382
64Ependymoma (HP:0002888)1.79891306
65Hyperglycinemia (HP:0002154)1.79630057
66Neoplasm of the oral cavity (HP:0100649)1.79207727
67Gonadotropin excess (HP:0000837)1.79144958
68Abnormality of the metopic suture (HP:0005556)1.78847001
69Dyskinesia (HP:0100660)1.78786657
70Lipid accumulation in hepatocytes (HP:0006561)1.78721390
71Clubbing of toes (HP:0100760)1.78456254
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.78141645
73Short tibia (HP:0005736)1.78037413
74Rhabdomyosarcoma (HP:0002859)1.77567658
75Growth hormone deficiency (HP:0000824)1.76693074
76Abnormality of the vitamin B12 metabolism (HP:0004341)1.75762331
77Cortical dysplasia (HP:0002539)1.75754581
78Abnormality of the astrocytes (HP:0100707)1.75577332
79Astrocytoma (HP:0009592)1.75577332
80Postaxial foot polydactyly (HP:0001830)1.74819231
81Progressive macrocephaly (HP:0004481)1.74736344
82Astigmatism (HP:0000483)1.73449324
83Median cleft lip (HP:0000161)1.72411077
84Specific learning disability (HP:0001328)1.72352703
85Pendular nystagmus (HP:0012043)1.71959058
86Labial hypoplasia (HP:0000066)1.71192783
87Progressive cerebellar ataxia (HP:0002073)1.70082673
88Postaxial hand polydactyly (HP:0001162)1.69638829
89Absent septum pellucidum (HP:0001331)1.66866938
90Broad-based gait (HP:0002136)1.66046808
91Abnormality of homocysteine metabolism (HP:0010919)1.65993562
92Homocystinuria (HP:0002156)1.65993562
93Dandy-Walker malformation (HP:0001305)1.65697108
94Prominent metopic ridge (HP:0005487)1.65126070
95Abnormality of methionine metabolism (HP:0010901)1.64871707
96Atonic seizures (HP:0010819)1.64831098
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64193010
98Stenosis of the external auditory canal (HP:0000402)1.64191037
99Acute necrotizing encephalopathy (HP:0006965)1.63700960
100Hypoplastic female external genitalia (HP:0012815)1.63237773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.02253632
2TRIM282.94737779
3WNK32.78666935
4TNIK2.47114068
5BRSK22.42365204
6ERBB32.42263776
7TSSK62.37947093
8SRPK12.35561557
9MAP3K42.32261497
10BMPR1B2.24459485
11WEE12.14917789
12ZAK2.14109119
13MKNK22.08143071
14CASK2.07351095
15PLK42.06481988
16CDC72.03412437
17NUAK12.00938355
18BCR1.92298710
19EIF2AK31.90228934
20PLK31.89797376
21BUB11.88454824
22MST41.86279448
23ACVR1B1.84246363
24TTK1.83771768
25EPHA41.72691687
26MKNK11.58757730
27MAP4K21.51897346
28NEK11.48752894
29BRD41.37865090
30PLK11.33403577
31CSNK1G11.33354578
32CSNK1G21.27606175
33MAPK131.26404043
34MAP2K71.23987573
35FGFR21.23032673
36PLK21.19430786
37CSNK1A1L1.17919518
38VRK11.17660808
39PBK1.15839882
40CSNK1G31.13352845
41DYRK21.10851823
42STK31.05556217
43ATR1.03994485
44STK38L1.02069464
45NLK1.01368998
46MARK11.01093353
47PNCK0.99757117
48BRSK10.95269702
49ATM0.88427431
50PAK30.84351117
51EIF2AK10.80217339
52TAF10.79496628
53GRK10.78859487
54EIF2AK20.78773340
55DYRK30.78435375
56CAMKK20.77520323
57STK160.76677494
58EPHA30.72782610
59CHEK10.70608394
60LATS10.67941993
61NTRK30.67839375
62RPS6KA40.66938790
63PRKCE0.65440083
64VRK20.64655825
65AKT30.64366700
66ERBB40.64056385
67PINK10.63541421
68CHEK20.62224087
69CDK30.61955349
70SGK20.59746310
71FGFR10.59599073
72NEK20.59095006
73STK390.58849801
74TGFBR10.58404171
75NME10.57808303
76OXSR10.57715448
77PRKCG0.52199226
78CAMK1G0.51655786
79CSNK1E0.50694843
80INSRR0.48626727
81CSNK1D0.48471377
82ADRBK20.48339407
83YES10.48103216
84AURKB0.47435404
85PRKDC0.46607966
86PASK0.45540455
87UHMK10.44186704
88CSNK1A10.43935918
89CDK10.43064294
90DYRK1A0.42604228
91BCKDK0.39993580
92OBSCN0.39747960
93NTRK20.39670176
94CDK20.38758670
95PRKACB0.37737559
96SGK2230.36222765
97SGK4940.36222765
98CDK70.34207961
99WNK40.33022432
100MAP3K100.32341572

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.99818476
2Non-homologous end-joining_Homo sapiens_hsa034502.97893156
3Fanconi anemia pathway_Homo sapiens_hsa034602.91737748
4Protein export_Homo sapiens_hsa030602.70492975
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69117771
6RNA polymerase_Homo sapiens_hsa030202.66733368
7DNA replication_Homo sapiens_hsa030302.61541476
8Basal transcription factors_Homo sapiens_hsa030222.48609625
9Homologous recombination_Homo sapiens_hsa034402.47708069
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42571372
11RNA degradation_Homo sapiens_hsa030182.36056037
12RNA transport_Homo sapiens_hsa030132.24342182
13Propanoate metabolism_Homo sapiens_hsa006402.14724402
14Cell cycle_Homo sapiens_hsa041102.05273640
15Proteasome_Homo sapiens_hsa030502.01606566
16Spliceosome_Homo sapiens_hsa030401.96970392
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95781987
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92287827
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76399848
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74015436
21Nucleotide excision repair_Homo sapiens_hsa034201.71568257
22Butanoate metabolism_Homo sapiens_hsa006501.68314175
23mRNA surveillance pathway_Homo sapiens_hsa030151.64555759
24Nicotine addiction_Homo sapiens_hsa050331.63599563
25One carbon pool by folate_Homo sapiens_hsa006701.53834414
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47099998
27Selenocompound metabolism_Homo sapiens_hsa004501.44868637
28Steroid biosynthesis_Homo sapiens_hsa001001.43208190
29Oocyte meiosis_Homo sapiens_hsa041141.42878996
30Oxidative phosphorylation_Homo sapiens_hsa001901.42423309
31Base excision repair_Homo sapiens_hsa034101.41566756
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.38184787
33Parkinsons disease_Homo sapiens_hsa050121.33477948
34Phototransduction_Homo sapiens_hsa047441.33337771
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29428155
36Fatty acid elongation_Homo sapiens_hsa000621.25963292
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20489592
38p53 signaling pathway_Homo sapiens_hsa041151.19403437
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17762246
40Huntingtons disease_Homo sapiens_hsa050161.15253721
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14957112
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04880456
43Circadian rhythm_Homo sapiens_hsa047101.03805653
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01421791
45Purine metabolism_Homo sapiens_hsa002301.00661672
46Pyrimidine metabolism_Homo sapiens_hsa002400.97791106
47Taste transduction_Homo sapiens_hsa047420.91754535
48GABAergic synapse_Homo sapiens_hsa047270.91368990
49Lysine degradation_Homo sapiens_hsa003100.90292739
50beta-Alanine metabolism_Homo sapiens_hsa004100.87390875
51Caffeine metabolism_Homo sapiens_hsa002320.83631466
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83601417
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82336125
54Vitamin B6 metabolism_Homo sapiens_hsa007500.81533280
55Regulation of autophagy_Homo sapiens_hsa041400.79452414
56Peroxisome_Homo sapiens_hsa041460.72291885
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67735778
58Alzheimers disease_Homo sapiens_hsa050100.66577980
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66035530
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.65756548
61Wnt signaling pathway_Homo sapiens_hsa043100.64070777
62Pyruvate metabolism_Homo sapiens_hsa006200.63787380
63Hedgehog signaling pathway_Homo sapiens_hsa043400.60367547
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56215784
65Nitrogen metabolism_Homo sapiens_hsa009100.56212998
66Olfactory transduction_Homo sapiens_hsa047400.56108435
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56034654
68Hippo signaling pathway_Homo sapiens_hsa043900.55507495
69Basal cell carcinoma_Homo sapiens_hsa052170.54576060
70Folate biosynthesis_Homo sapiens_hsa007900.54303592
71Metabolic pathways_Homo sapiens_hsa011000.53872178
72Morphine addiction_Homo sapiens_hsa050320.52879938
73TGF-beta signaling pathway_Homo sapiens_hsa043500.52540817
74Fatty acid metabolism_Homo sapiens_hsa012120.50336141
75Tryptophan metabolism_Homo sapiens_hsa003800.50278091
76Dopaminergic synapse_Homo sapiens_hsa047280.50032134
77Ether lipid metabolism_Homo sapiens_hsa005650.48540642
78Glutamatergic synapse_Homo sapiens_hsa047240.46459971
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45061158
80Serotonergic synapse_Homo sapiens_hsa047260.44886332
81Circadian entrainment_Homo sapiens_hsa047130.42876098
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41841107
83Alcoholism_Homo sapiens_hsa050340.37580716
84Amphetamine addiction_Homo sapiens_hsa050310.37518090
85Linoleic acid metabolism_Homo sapiens_hsa005910.35790022
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30812820
87Long-term depression_Homo sapiens_hsa047300.30196081
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30162248
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28635075
90Tight junction_Homo sapiens_hsa045300.27147244
91Retinol metabolism_Homo sapiens_hsa008300.26881844
92Adherens junction_Homo sapiens_hsa045200.25634416
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25584937
94Ribosome_Homo sapiens_hsa030100.25082500
95Insulin secretion_Homo sapiens_hsa049110.24412538
96Fatty acid degradation_Homo sapiens_hsa000710.24140856
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23331331
98Cocaine addiction_Homo sapiens_hsa050300.22919752
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22032657
100Cardiac muscle contraction_Homo sapiens_hsa042600.21135357

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