ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	7.73962045
2	male meiosis I (GO:0007141)	6.06727904
3	regulation of meiosis I (GO:0060631)	5.94463105
4	positive regulation of protein homooligomerization (GO:0032464)	5.51289011
5	DNA methylation involved in gamete generation (GO:0043046)	5.33474254
6	rRNA methylation (GO:0031167)	5.29117580
7	rRNA modification (GO:0000154)	5.26032530
8	meiosis I (GO:0007127)	5.13560326
9	synapsis (GO:0007129)	5.08839481
10	regulation of DNA methylation (GO:0044030)	5.07022669
11	male meiosis (GO:0007140)	4.77003459
12	meiotic cell cycle (GO:0051321)	4.30345769
13	regulation of female gonad development (GO:2000194)	4.29750891
14	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.20553576
15	regulation of acrosome reaction (GO:0060046)	4.10543624
16	multicellular organism reproduction (GO:0032504)	3.93061855
17	gene silencing by RNA (GO:0031047)	3.77907960
18	meiotic nuclear division (GO:0007126)	3.76767189
19	mitotic metaphase plate congression (GO:0007080)	3.74640634
20	meiotic cell cycle process (GO:1903046)	3.71392930
21	retinal cone cell development (GO:0046549)	3.68740608
22	chromosome organization involved in meiosis (GO:0070192)	3.68501769
23	transcription from mitochondrial promoter (GO:0006390)	3.63152544
24	positive regulation of histone H3-K4 methylation (GO:0051571)	3.56295295
25	gonadal mesoderm development (GO:0007506)	3.54782532
26	seminiferous tubule development (GO:0072520)	3.54210583
27	positive regulation of meiotic cell cycle (GO:0051446)	3.50451049
28	metaphase plate congression (GO:0051310)	3.28146096
29	positive regulation of chromosome segregation (GO:0051984)	3.27629176
30	female gamete generation (GO:0007292)	3.24724810
31	CENP-A containing nucleosome assembly (GO:0034080)	3.15769531
32	synaptonemal complex organization (GO:0070193)	3.14685542
33	synaptonemal complex assembly (GO:0007130)	3.14487072
34	centriole replication (GO:0007099)	3.12053903
35	positive regulation of meiosis (GO:0045836)	3.09274544
36	protein K6-linked ubiquitination (GO:0085020)	3.09249981
37	attachment of spindle microtubules to kinetochore (GO:0008608)	3.06317136
38	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.05405256
39	negative regulation of meiosis (GO:0045835)	3.05285463
40	regulation of protein homooligomerization (GO:0032462)	3.02691425
41	N-terminal protein amino acid acetylation (GO:0006474)	3.01637633
42	autophagic vacuole assembly (GO:0000045)	2.99866682
43	binding of sperm to zona pellucida (GO:0007339)	2.99297235
44	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.95041092
45	proteasome assembly (GO:0043248)	2.94414096
46	ventricular cardiac muscle cell development (GO:0055015)	2.93845500
47	chromatin remodeling at centromere (GO:0031055)	2.90341742
48	sperm-egg recognition (GO:0035036)	2.83067559
49	sister chromatid cohesion (GO:0007062)	2.80710088
50	aggressive behavior (GO:0002118)	2.80246840
51	meiotic chromosome segregation (GO:0045132)	2.79321240
52	histone exchange (GO:0043486)	2.77853936
53	mitotic chromosome condensation (GO:0007076)	2.76432583
54	single strand break repair (GO:0000012)	2.75889922
55	regulation of meiosis (GO:0040020)	2.75656494
56	regulation of meiotic cell cycle (GO:0051445)	2.70516469
57	glycine transport (GO:0015816)	2.70082034
58	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.69065577
59	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.69065577
60	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.69065577
61	spermatogenesis (GO:0007283)	2.68368799
62	male gamete generation (GO:0048232)	2.67999123
63	fertilization (GO:0009566)	2.67986808
64	gamete generation (GO:0007276)	2.66459483
65	acrosome assembly (GO:0001675)	2.65959881
66	mitotic sister chromatid cohesion (GO:0007064)	2.65605515
67	mitochondrial RNA metabolic process (GO:0000959)	2.64461563
68	oocyte development (GO:0048599)	2.63862903
69	oogenesis (GO:0048477)	2.63806541
70	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.63697953
71	resolution of meiotic recombination intermediates (GO:0000712)	2.62023724
72	negative regulation of meiotic cell cycle (GO:0051447)	2.61465175
73	regulation of penile erection (GO:0060405)	2.61273048
74	negative regulation of reproductive process (GO:2000242)	2.60417179
75	regulation of histone H3-K9 methylation (GO:0051570)	2.60324753
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.58765431
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.58765431
78	acrosome reaction (GO:0007340)	2.58035178
79	intestinal epithelial cell development (GO:0060576)	2.55257823
80	DNA replication checkpoint (GO:0000076)	2.55010911
81	reproduction (GO:0000003)	2.53408734
82	protein polyglutamylation (GO:0018095)	2.53214681
83	response to UV-C (GO:0010225)	2.51472468
84	establishment of chromosome localization (GO:0051303)	2.51379495
85	DNA alkylation (GO:0006305)	2.48999839
86	DNA methylation (GO:0006306)	2.48999839
87	respiratory chain complex IV assembly (GO:0008535)	2.47583385
88	magnesium ion transport (GO:0015693)	2.47548480
89	pyrimidine dimer repair (GO:0006290)	2.46828116
90	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.45488781
91	histone H2A acetylation (GO:0043968)	2.44975576
92	termination of RNA polymerase III transcription (GO:0006386)	2.43380392
93	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.43380392
94	ribosome assembly (GO:0042255)	2.43086224
95	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.42712605
96	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.42712605
97	spermatid development (GO:0007286)	2.42650086
98	nucleotide transmembrane transport (GO:1901679)	2.42630917
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	17.2005232
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	14.7183185

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.33348021
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.04392768
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65020348
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.39066059
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.30233877
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.28422352
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.01881081
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.82515972
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.76554520
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.56715833
11	VDR_22108803_ChIP-Seq_LS180_Human	2.56357549
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.54748028
13	E2F7_22180533_ChIP-Seq_HELA_Human	2.51071072
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50762859
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.49411909
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.35855759
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.16288435
18	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.97623205
19	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.97623205
20	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.97623205
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.97032094
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.96535925
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91024615
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.86672093
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.83390767
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.76751228
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.76726737
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.73842034
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.69685169
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.62619499
31	EWS_26573619_Chip-Seq_HEK293_Human	1.61910850
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.59353844
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57402786
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.52895345
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52422854
36	P300_19829295_ChIP-Seq_ESCs_Human	1.51163221
37	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.51141276
38	FUS_26573619_Chip-Seq_HEK293_Human	1.50898030
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50213107
40	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.49858156
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48152849
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.47785641
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46029063
44	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37576329
45	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.35536004
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.33826432
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32903721
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.31738528
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.25094317
50	NFYB_21822215_ChIP-Seq_K562_Human	1.23190157
51	ETV1_20927104_ChIP-Seq_GIST48_Human	1.22417575
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.18153692
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18008750
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.17842568
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17842568
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17022380
57	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.16586334
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.15334125
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15232752
60	PHF8_20622853_ChIP-Seq_HELA_Human	1.15170920
61	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.14530581
62	RBPJ_21746931_ChIP-Seq_IB4_Human	1.11655174
63	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.10845219
64	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09431349
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.08969248
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.08848185
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08719098
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08719098
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.07934285
70	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07684901
71	STAT3_23295773_ChIP-Seq_U87_Human	1.06480055
72	TBL1_22424771_ChIP-Seq_293T_Human	1.06197892
73	NCOR_22424771_ChIP-Seq_293T_Human	1.04243532
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03964636
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03317404
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03129219
77	TCF4_23295773_ChIP-Seq_U87_Human	1.01581781
78	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01565111
79	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.99891542
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99679529
81	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.99256555
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.96728860
83	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96457350
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96398535
85	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94932170
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94902895
87	AR_25329375_ChIP-Seq_VCAP_Human	0.94447355
88	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.94084781
89	AR_20517297_ChIP-Seq_VCAP_Human	0.93657496
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93455852
91	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92047599
92	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.91415335
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.90987323
94	TCF4_22108803_ChIP-Seq_LS180_Human	0.90901445
95	NFYA_21822215_ChIP-Seq_K562_Human	0.90778911
96	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.89654416
97	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.88688035
98	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87819386
99	AR_21909140_ChIP-Seq_LNCAP_Human	0.87806531
100	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.87438031

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	4.87586008
2	MP0008877_abnormal_DNA_methylation	4.42548219
3	MP0001986_abnormal_taste_sensitivity	4.41136688
4	MP0003693_abnormal_embryo_hatching	3.45898278
5	MP0006292_abnormal_olfactory_placode	3.37006318
6	MP0008058_abnormal_DNA_repair	2.97408078
7	MP0005423_abnormal_somatic_nervous	2.82565849
8	MP0001929_abnormal_gametogenesis	2.64139574
9	MP0002210_abnormal_sex_determination	2.44700785
10	MP0003646_muscle_fatigue	2.18237403
11	MP0008995_early_reproductive_senescence	2.17767186
12	MP0010094_abnormal_chromosome_stability	2.14620709
13	MP0005410_abnormal_fertilization	2.12948331
14	MP0002160_abnormal_reproductive_system	2.06697384
15	MP0002138_abnormal_hepatobiliary_system	1.99392185
16	MP0003698_abnormal_male_reproductive	1.95700929
17	MP0005395_other_phenotype	1.92187818
18	MP0000653_abnormal_sex_gland	1.83356618
19	MP0005647_abnormal_sex_gland	1.82856648
20	MP0001145_abnormal_male_reproductive	1.76213674
21	MP0004957_abnormal_blastocyst_morpholog	1.74517009
22	MP0003077_abnormal_cell_cycle	1.72004413
23	MP0003111_abnormal_nucleus_morphology	1.69225936
24	MP0008789_abnormal_olfactory_epithelium	1.69119399
25	MP0005367_renal/urinary_system_phenotyp	1.67967258
26	MP0000516_abnormal_urinary_system	1.67967258
27	MP0005646_abnormal_pituitary_gland	1.54772480
28	MP0005389_reproductive_system_phenotype	1.49705714
29	MP0002161_abnormal_fertility/fecundity	1.48912681
30	MP0005394_taste/olfaction_phenotype	1.46888807
31	MP0005499_abnormal_olfactory_system	1.46888807
32	MP0001188_hyperpigmentation	1.42048321
33	MP0003699_abnormal_female_reproductive	1.39365062
34	MP0003183_abnormal_peptide_metabolism	1.37938700
35	MP0005645_abnormal_hypothalamus_physiol	1.37723391
36	MP0006276_abnormal_autonomic_nervous	1.35798843
37	MP0004215_abnormal_myocardial_fiber	1.35286374
38	MP0008260_abnormal_autophagy	1.29628430
39	MP0003880_abnormal_central_pattern	1.28829328
40	MP0002127_abnormal_cardiovascular_syste	1.28697013
41	MP0005551_abnormal_eye_electrophysiolog	1.28190933
42	MP0003195_calcinosis	1.24933067
43	MP0001119_abnormal_female_reproductive	1.20804670
44	MP0010368_abnormal_lymphatic_system	1.18809826
45	MP0000631_abnormal_neuroendocrine_gland	1.17484590
46	MP0000015_abnormal_ear_pigmentation	1.16354587
47	MP0004147_increased_porphyrin_level	1.15124796
48	MP0001730_embryonic_growth_arrest	1.12726671
49	MP0010307_abnormal_tumor_latency	1.11847196
50	MP0003786_premature_aging	1.11302603
51	MP0003950_abnormal_plasma_membrane	1.06586980
52	MP0006035_abnormal_mitochondrial_morpho	1.06207971
53	MP0003119_abnormal_digestive_system	1.06198681
54	MP0000049_abnormal_middle_ear	1.04735435
55	MP0006072_abnormal_retinal_apoptosis	1.02861176
56	MP0006036_abnormal_mitochondrial_physio	1.02201091
57	MP0002102_abnormal_ear_morphology	1.01961224
58	MP0001764_abnormal_homeostasis	0.98399147
59	MP0000427_abnormal_hair_cycle	0.96746581
60	MP0005253_abnormal_eye_physiology	0.94869900
61	MP0005380_embryogenesis_phenotype	0.93099853
62	MP0001672_abnormal_embryogenesis/_devel	0.93099853
63	MP0004142_abnormal_muscle_tone	0.92065296
64	MP0008932_abnormal_embryonic_tissue	0.91551746
65	MP0001486_abnormal_startle_reflex	0.88861194
66	MP0002735_abnormal_chemical_nociception	0.88574350
67	MP0003567_abnormal_fetal_cardiomyocyte	0.87553469
68	MP0005379_endocrine/exocrine_gland_phen	0.85997331
69	MP0003121_genomic_imprinting	0.85314317
70	MP0002751_abnormal_autonomic_nervous	0.84804472
71	MP0002822_catalepsy	0.83407303
72	MP0005085_abnormal_gallbladder_physiolo	0.82293770
73	MP0003890_abnormal_embryonic-extraembry	0.81633028
74	MP0003252_abnormal_bile_duct	0.79933118
75	MP0005670_abnormal_white_adipose	0.79492353
76	MP0001697_abnormal_embryo_size	0.79153328
77	MP0001529_abnormal_vocalization	0.78989269
78	MP0000372_irregular_coat_pigmentation	0.78125083
79	MP0002084_abnormal_developmental_patter	0.77426523
80	MP0002272_abnormal_nervous_system	0.76033819
81	MP0002163_abnormal_gland_morphology	0.73120485
82	MP0003943_abnormal_hepatobiliary_system	0.72955273
83	MP0009697_abnormal_copulation	0.72855577
84	MP0005084_abnormal_gallbladder_morpholo	0.71401187
85	MP0000358_abnormal_cell_content/	0.71341213
86	MP0004885_abnormal_endolymph	0.71194756
87	MP0001919_abnormal_reproductive_system	0.71147784
88	MP0003136_yellow_coat_color	0.70732668
89	MP0004043_abnormal_pH_regulation	0.70600179
90	MP0005075_abnormal_melanosome_morpholog	0.70277110
91	MP0001666_abnormal_nutrient_absorption	0.68753441
92	MP0009745_abnormal_behavioral_response	0.68376924
93	MP0004019_abnormal_vitamin_homeostasis	0.67076162
94	MP0001968_abnormal_touch/_nociception	0.64961142
95	MP0002234_abnormal_pharynx_morphology	0.64353171
96	MP0000350_abnormal_cell_proliferation	0.62909962
97	MP0003123_paternal_imprinting	0.61943349
98	MP0000647_abnormal_sebaceous_gland	0.61815568
99	MP0001293_anophthalmia	0.60595155
100	MP0008872_abnormal_physiological_respon	0.60584550

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Male infertility (HP:0003251)	4.45245133
2	Tubulointerstitial nephritis (HP:0001970)	3.87202094
3	Hyperalaninemia (HP:0003348)	2.97069150
4	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.97069150
5	Abnormality of alanine metabolism (HP:0010916)	2.97069150
6	Congenital malformation of the right heart (HP:0011723)	2.85791011
7	Double outlet right ventricle (HP:0001719)	2.85791011
8	Aplasia/hypoplasia of the uterus (HP:0008684)	2.85701112
9	Short tibia (HP:0005736)	2.84725827
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.79744227
11	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.75912737
12	Hypoplasia of the uterus (HP:0000013)	2.70461526
13	Premature ovarian failure (HP:0008209)	2.68620866
14	Chromsome breakage (HP:0040012)	2.60590044
15	Attenuation of retinal blood vessels (HP:0007843)	2.59255246
16	Supernumerary spleens (HP:0009799)	2.57374437
17	Hypoplasia of the fovea (HP:0007750)	2.56859278
18	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.56859278
19	Gonadotropin excess (HP:0000837)	2.54534028
20	Pendular nystagmus (HP:0012043)	2.54480788
21	Azoospermia (HP:0000027)	2.52534091
22	Abnormal spermatogenesis (HP:0008669)	2.50701213
23	Posterior subcapsular cataract (HP:0007787)	2.49357325
24	Molar tooth sign on MRI (HP:0002419)	2.46046990
25	Abnormality of midbrain morphology (HP:0002418)	2.46046990
26	Abnormality of the labia minora (HP:0012880)	2.44344047
27	Hypoglycemic seizures (HP:0002173)	2.42609536
28	Median cleft lip (HP:0000161)	2.40751215
29	Osteomalacia (HP:0002749)	2.40151557
30	Birth length less than 3rd percentile (HP:0003561)	2.39480847
31	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.34253591
32	Hypergonadotropic hypogonadism (HP:0000815)	2.34002775
33	Pancreatic cysts (HP:0001737)	2.32684218
34	Hyperglycemia (HP:0003074)	2.31146252
35	Abnormality of the fovea (HP:0000493)	2.28789430
36	Meckel diverticulum (HP:0002245)	2.24995189
37	Carpal bone hypoplasia (HP:0001498)	2.24801607
38	Infertility (HP:0000789)	2.21293646
39	Abnormality of urine glucose concentration (HP:0011016)	2.21072879
40	Glycosuria (HP:0003076)	2.21072879
41	Medial flaring of the eyebrow (HP:0010747)	2.18202910
42	Abnormality of the ileum (HP:0001549)	2.17897463
43	Abnormality of macular pigmentation (HP:0008002)	2.15398398
44	Horseshoe kidney (HP:0000085)	2.15326779
45	Decreased central vision (HP:0007663)	2.13990096
46	Generalized aminoaciduria (HP:0002909)	2.12574408
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09981243
48	Ureteral duplication (HP:0000073)	2.09173050
49	Oligodactyly (hands) (HP:0001180)	2.08719014
50	Methylmalonic acidemia (HP:0002912)	2.08360246
51	Abnormality of the preputium (HP:0100587)	2.06167583
52	Ependymoma (HP:0002888)	2.05565820
53	Hypophosphatemic rickets (HP:0004912)	2.05404702
54	Short 1st metacarpal (HP:0010034)	2.04204231
55	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.04204231
56	Hypoglycemic coma (HP:0001325)	2.04202998
57	Abolished electroretinogram (ERG) (HP:0000550)	2.03074202
58	Cerebral hypomyelination (HP:0006808)	2.02627426
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.00522183
60	Proximal tubulopathy (HP:0000114)	2.00280362
61	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.97901485
62	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.97901485
63	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.97569580
64	Pancreatic fibrosis (HP:0100732)	1.94629336
65	Progressive inability to walk (HP:0002505)	1.93917451
66	Microvesicular hepatic steatosis (HP:0001414)	1.93891554
67	Abnormality of lateral ventricle (HP:0030047)	1.93626675
68	Abnormality of the renal collecting system (HP:0004742)	1.93014223
69	Abdominal situs inversus (HP:0003363)	1.92758455
70	Abnormality of abdominal situs (HP:0011620)	1.92758455
71	Gaze-evoked nystagmus (HP:0000640)	1.91873486
72	Progressive cerebellar ataxia (HP:0002073)	1.91855948
73	Absent radius (HP:0003974)	1.91796015
74	Abnormality of pyrimidine metabolism (HP:0004353)	1.90127723
75	Subcapsular cataract (HP:0000523)	1.89222978
76	Nephronophthisis (HP:0000090)	1.87370562
77	Absent thumb (HP:0009777)	1.85392544
78	Severe visual impairment (HP:0001141)	1.84455475
79	Cone-rod dystrophy (HP:0000548)	1.83579454
80	Abnormal lung lobation (HP:0002101)	1.82575039
81	Abnormal rod and cone electroretinograms (HP:0008323)	1.81437466
82	Abnormal biliary tract morphology (HP:0012440)	1.80868458
83	Absent forearm bone (HP:0003953)	1.80436740
84	Aplasia involving forearm bones (HP:0009822)	1.80436740
85	CNS hypomyelination (HP:0003429)	1.79377293
86	Abnormality of the 1st metacarpal (HP:0010009)	1.78094789
87	Bony spicule pigmentary retinopathy (HP:0007737)	1.77446905
88	Astrocytoma (HP:0009592)	1.77446203
89	Abnormality of the astrocytes (HP:0100707)	1.77446203
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.76864839
91	Male pseudohermaphroditism (HP:0000037)	1.75475813
92	Ectopic kidney (HP:0000086)	1.74740219
93	Abnormal pancreas size (HP:0012094)	1.73207176
94	Agnosia (HP:0010524)	1.72957718
95	Inability to walk (HP:0002540)	1.72404181
96	Dyskinesia (HP:0100660)	1.72250942
97	True hermaphroditism (HP:0010459)	1.72240080
98	Retinal dysplasia (HP:0007973)	1.72017077
99	Fused cervical vertebrae (HP:0002949)	1.71097601
100	Tongue fasciculations (HP:0001308)	1.71011875

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.18678878
2	INSRR	3.05436983
3	TRIM28	3.03478508
4	MAP4K2	2.90523378
5	ACVR1B	2.89988178
6	BUB1	2.69994395
7	CDK19	2.57271447
8	SRPK1	2.46054284
9	PLK4	2.44040376
10	ZAK	2.27976966
11	STK16	2.22244672
12	TTK	1.92632315
13	PLK1	1.91738135
14	PLK3	1.86648690
15	PINK1	1.78948734
16	MAP3K4	1.72501491
17	WNK3	1.71173683
18	NUAK1	1.64939534
19	TESK2	1.63567755
20	NEK6	1.60687543
21	PBK	1.49185171
22	BMPR1B	1.48071782
23	MST4	1.47761601
24	AURKA	1.46478689
25	OXSR1	1.40624604
26	TAOK3	1.39146228
27	BRSK2	1.38527331
28	BRSK1	1.35009994
29	STK39	1.25217611
30	AKT3	1.25130166
31	EIF2AK3	1.24939533
32	CSNK1G2	1.24370464
33	CSNK1G1	1.14361903
34	CSNK1G3	1.09122966
35	PLK2	1.08452867
36	GRK1	1.03613189
37	PRKCE	0.99646150
38	NTRK3	0.98788909
39	CHEK1	0.98566461
40	MAP3K9	0.98368423
41	ADRBK2	0.97098098
42	PHKG1	0.94514954
43	PHKG2	0.94514954
44	YES1	0.94035289
45	MAPK13	0.93973022
46	CDC7	0.93572856
47	NEK2	0.92172204
48	BCR	0.91744292
49	VRK1	0.89503325
50	STK3	0.89415050
51	PDK2	0.87087682
52	AURKB	0.86521334
53	CHEK2	0.86175251
54	PRKCI	0.83566777
55	MAP2K7	0.74653492
56	BRAF	0.72004638
57	ERBB3	0.70711745
58	ATR	0.69155556
59	MKNK2	0.68687822
60	ATM	0.68260649
61	CSNK1A1L	0.67197804
62	CSNK1E	0.67114493
63	RAF1	0.65565402
64	CSNK2A1	0.65304450
65	MKNK1	0.64873540
66	PRKG1	0.64658899
67	CDK7	0.64297926
68	EPHA4	0.63690658
69	BRD4	0.63500351
70	PRKCG	0.61902786
71	PIM1	0.61545399
72	TYRO3	0.60533769
73	STK38L	0.60383138
74	CSNK1A1	0.57528192
75	PAK1	0.53278868
76	STK24	0.52474173
77	DYRK3	0.51468945
78	MELK	0.51417257
79	CCNB1	0.50551617
80	PAK6	0.50246361
81	PRKACB	0.49383497
82	CSNK2A2	0.47265251
83	CDK2	0.47083163
84	PKN1	0.46771659
85	MUSK	0.46177821
86	CDK1	0.45598968
87	PRKACA	0.43335794
88	LATS2	0.41044764
89	CSNK1D	0.39099686
90	KSR1	0.38965610
91	TGFBR1	0.38361635
92	WNK4	0.34460992
93	WEE1	0.34213500
94	TIE1	0.33185524
95	ERBB4	0.32943380
96	CDK3	0.32381772
97	PRKG2	0.32347294
98	KSR2	0.31470961
99	CAMK2A	0.31246790
100	PRKAA1	0.30294145

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.93032323
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.62786194
3	Regulation of autophagy_Homo sapiens_hsa04140	3.47449593
4	RNA transport_Homo sapiens_hsa03013	2.97213756
5	RNA polymerase_Homo sapiens_hsa03020	2.68885350
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.61668254
7	Mismatch repair_Homo sapiens_hsa03430	2.51883570
8	RNA degradation_Homo sapiens_hsa03018	2.35826151
9	Homologous recombination_Homo sapiens_hsa03440	2.29548330
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.18561291
11	Base excision repair_Homo sapiens_hsa03410	2.18447662
12	Oocyte meiosis_Homo sapiens_hsa04114	2.12872056
13	Cell cycle_Homo sapiens_hsa04110	2.09082551
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.06006791
15	mRNA surveillance pathway_Homo sapiens_hsa03015	1.96802911
16	Protein export_Homo sapiens_hsa03060	1.89090837
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.80567867
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.66660502
19	Caffeine metabolism_Homo sapiens_hsa00232	1.64689947
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.59335548
21	Spliceosome_Homo sapiens_hsa03040	1.52283811
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.49289311
23	Phototransduction_Homo sapiens_hsa04744	1.47604598
24	Folate biosynthesis_Homo sapiens_hsa00790	1.47175437
25	DNA replication_Homo sapiens_hsa03030	1.46635493
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.42979142
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41926962
28	Taste transduction_Homo sapiens_hsa04742	1.40567412
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38659048
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.36640803
31	p53 signaling pathway_Homo sapiens_hsa04115	1.29617755
32	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.27293495
33	Proteasome_Homo sapiens_hsa03050	1.26664655
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.25933179
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.21053898
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.18765003
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.18581889
38	Circadian rhythm_Homo sapiens_hsa04710	1.09600046
39	Olfactory transduction_Homo sapiens_hsa04740	1.09206550
40	Nicotine addiction_Homo sapiens_hsa05033	1.08984614
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07116144
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05165358
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04382108
44	Sulfur metabolism_Homo sapiens_hsa00920	0.99402524
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.96123310
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.91800444
47	Purine metabolism_Homo sapiens_hsa00230	0.91742165
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91718988
49	Fatty acid elongation_Homo sapiens_hsa00062	0.91604700
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.88478529
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86045985
52	Propanoate metabolism_Homo sapiens_hsa00640	0.84554186
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83168644
54	Huntingtons disease_Homo sapiens_hsa05016	0.81937446
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76215539
56	Butanoate metabolism_Homo sapiens_hsa00650	0.75310433
57	ABC transporters_Homo sapiens_hsa02010	0.75152125
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69477314
59	GABAergic synapse_Homo sapiens_hsa04727	0.63485363
60	Long-term depression_Homo sapiens_hsa04730	0.60842842
61	Insulin secretion_Homo sapiens_hsa04911	0.60277752
62	Serotonergic synapse_Homo sapiens_hsa04726	0.58059533
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.57033301
64	Retinol metabolism_Homo sapiens_hsa00830	0.56369927
65	Parkinsons disease_Homo sapiens_hsa05012	0.55282160
66	Oxidative phosphorylation_Homo sapiens_hsa00190	0.55216051
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53677697
68	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52970028
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50848955
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50091823
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48172003
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46361051
73	Metabolic pathways_Homo sapiens_hsa01100	0.45718392
74	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44344119
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43712006
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.42109732
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40695164
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.39927769
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.38966149
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38775337
81	Morphine addiction_Homo sapiens_hsa05032	0.35588035
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35515583
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.35433723
84	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.33692142
85	Cardiac muscle contraction_Homo sapiens_hsa04260	0.31686538
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31008479
87	Peroxisome_Homo sapiens_hsa04146	0.28660485
88	Circadian entrainment_Homo sapiens_hsa04713	0.27988159
89	Gap junction_Homo sapiens_hsa04540	0.27259448
90	Ribosome_Homo sapiens_hsa03010	0.26863260
91	Amphetamine addiction_Homo sapiens_hsa05031	0.26789373
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25598108
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.25064407
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.24567068
95	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.24545891
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24393300
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.24022130
98	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.23751574
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.23356428
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.23171735

ZNF723P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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