ZNF724P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of DNA-dependent DNA replication (GO:2000104)4.59449791
2behavioral response to nicotine (GO:0035095)4.42126115
3chromatin remodeling at centromere (GO:0031055)4.08705334
4replication fork processing (GO:0031297)4.04964233
5regulation of nuclear cell cycle DNA replication (GO:0033262)3.83098723
6CENP-A containing nucleosome assembly (GO:0034080)3.81693986
7DNA replication checkpoint (GO:0000076)3.81382951
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.74476393
9DNA double-strand break processing (GO:0000729)3.73301541
10DNA replication-dependent nucleosome assembly (GO:0006335)3.60967040
11DNA replication-dependent nucleosome organization (GO:0034723)3.60967040
12kinetochore organization (GO:0051383)3.44655327
13centriole replication (GO:0007099)3.43890365
14histone exchange (GO:0043486)3.43822871
15regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.39272591
16regulation of mitotic spindle checkpoint (GO:1903504)3.39272591
17protein localization to kinetochore (GO:0034501)3.39011586
18recombinational repair (GO:0000725)3.34787420
19double-strand break repair via homologous recombination (GO:0000724)3.30642032
20regulation of centriole replication (GO:0046599)3.29410979
21kinetochore assembly (GO:0051382)3.28640436
22microtubule depolymerization (GO:0007019)3.21207585
23DNA deamination (GO:0045006)3.13202968
24response to pheromone (GO:0019236)3.07452944
25postreplication repair (GO:0006301)3.01050347
26meiotic chromosome segregation (GO:0045132)2.99779043
27regulation of gene silencing by miRNA (GO:0060964)2.97107308
28regulation of gene silencing by RNA (GO:0060966)2.97107308
29regulation of posttranscriptional gene silencing (GO:0060147)2.97107308
30negative regulation of translation, ncRNA-mediated (GO:0040033)2.96144371
31regulation of translation, ncRNA-mediated (GO:0045974)2.96144371
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96144371
33DNA replication-independent nucleosome assembly (GO:0006336)2.95168955
34DNA replication-independent nucleosome organization (GO:0034724)2.95168955
35water-soluble vitamin biosynthetic process (GO:0042364)2.95078889
36protein K6-linked ubiquitination (GO:0085020)2.92302922
37somite development (GO:0061053)2.92152090
38centrosome organization (GO:0051297)2.91143208
39somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91081567
40somatic hypermutation of immunoglobulin genes (GO:0016446)2.91081567
41somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89367075
42somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89367075
43isotype switching (GO:0045190)2.89367075
44reciprocal DNA recombination (GO:0035825)2.88283852
45reciprocal meiotic recombination (GO:0007131)2.88283852
46L-fucose catabolic process (GO:0042355)2.88191489
47fucose catabolic process (GO:0019317)2.88191489
48L-fucose metabolic process (GO:0042354)2.88191489
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88122943
50protein-cofactor linkage (GO:0018065)2.84726548
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82581972
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79774802
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76448233
54pseudouridine synthesis (GO:0001522)2.76130666
55microtubule organizing center organization (GO:0031023)2.73297548
56negative regulation of telomere maintenance (GO:0032205)2.71780174
57translesion synthesis (GO:0019985)2.70200672
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70060117
59epithelial cilium movement (GO:0003351)2.68524768
60ncRNA catabolic process (GO:0034661)2.67710834
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66596890
62mitochondrial respiratory chain complex I assembly (GO:0032981)2.66596890
63NADH dehydrogenase complex assembly (GO:0010257)2.66596890
64protein complex biogenesis (GO:0070271)2.65811491
65mitochondrial respiratory chain complex assembly (GO:0033108)2.65554504
66regulation of centrosome cycle (GO:0046605)2.64934708
67establishment of protein localization to mitochondrial membrane (GO:0090151)2.64213602
68protein localization to chromosome, centromeric region (GO:0071459)2.63990859
69DNA strand renaturation (GO:0000733)2.63704437
70negative regulation of DNA recombination (GO:0045910)2.63604986
71termination of RNA polymerase III transcription (GO:0006386)2.63538578
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.63538578
73regulation of telomere maintenance (GO:0032204)2.62342866
74nonmotile primary cilium assembly (GO:0035058)2.61291748
75mitochondrial RNA metabolic process (GO:0000959)2.61264696
76microtubule polymerization or depolymerization (GO:0031109)2.60982591
77synapsis (GO:0007129)2.59820473
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59690594
79resolution of meiotic recombination intermediates (GO:0000712)2.57914449
80respiratory chain complex IV assembly (GO:0008535)2.57495225
81female gonad development (GO:0008585)2.55784101
82regulation of DNA endoreduplication (GO:0032875)2.55327757
83male meiosis I (GO:0007141)2.55284527
84regulation of mesoderm development (GO:2000380)2.55204453
85preassembly of GPI anchor in ER membrane (GO:0016254)2.53351984
86kidney morphogenesis (GO:0060993)2.48080612
87cilium morphogenesis (GO:0060271)2.47916816
88platelet dense granule organization (GO:0060155)2.44716179
89regulation of centrosome duplication (GO:0010824)2.42626323
90DNA catabolic process, exonucleolytic (GO:0000738)2.42046889
91mitotic G2/M transition checkpoint (GO:0044818)2.41858432
92regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.41717073
93double-strand break repair (GO:0006302)2.41403186
94DNA damage response, detection of DNA damage (GO:0042769)2.40653542
95behavioral response to ethanol (GO:0048149)2.40346248
96neural tube formation (GO:0001841)2.40293197
97DNA recombination (GO:0006310)2.39853672
98response to X-ray (GO:0010165)2.39239437
99regulation of meiosis I (GO:0060631)2.36696364
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.36604529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.67932332
2E2F7_22180533_ChIP-Seq_HELA_Human3.10871932
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.99488871
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94013779
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.92868049
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83517319
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75986804
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75617894
9VDR_22108803_ChIP-Seq_LS180_Human2.70424101
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55406011
11EWS_26573619_Chip-Seq_HEK293_Human2.44666873
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.41785942
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36546579
14FUS_26573619_Chip-Seq_HEK293_Human2.33583796
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.29271748
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26776582
17GBX2_23144817_ChIP-Seq_PC3_Human2.24428084
18IGF1R_20145208_ChIP-Seq_DFB_Human2.15629210
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15011069
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14546299
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.09358013
22TAF15_26573619_Chip-Seq_HEK293_Human2.02381241
23P300_19829295_ChIP-Seq_ESCs_Human2.00459745
24MYC_18940864_ChIP-ChIP_HL60_Human1.93257253
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89306722
26EZH2_22144423_ChIP-Seq_EOC_Human1.87829478
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86124941
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84708405
29ELK1_19687146_ChIP-ChIP_HELA_Human1.84254570
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.80906886
31IRF1_19129219_ChIP-ChIP_H3396_Human1.77557083
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68535384
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65162349
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63039374
35VDR_23849224_ChIP-Seq_CD4+_Human1.62383335
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.56978082
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55279816
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54835164
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44194523
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44193213
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44193213
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42624496
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.39400339
44ER_23166858_ChIP-Seq_MCF-7_Human1.37085253
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.36234302
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.35538236
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35511888
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34440286
49CBP_20019798_ChIP-Seq_JUKART_Human1.34440286
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32361562
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31028253
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30602959
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30289002
54TP53_22573176_ChIP-Seq_HFKS_Human1.29935045
55FOXP3_21729870_ChIP-Seq_TREG_Human1.29349577
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28605688
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27204784
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26604619
59BCAT_22108803_ChIP-Seq_LS180_Human1.26067996
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25926028
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24601133
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24483124
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21448581
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.17814865
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.17185475
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16355393
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16281621
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15603813
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15199736
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14585302
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14516265
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13971456
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.13763667
74SMAD4_21799915_ChIP-Seq_A2780_Human1.13671055
75STAT3_23295773_ChIP-Seq_U87_Human1.13385530
76RNF2_27304074_Chip-Seq_NSC_Mouse1.13244438
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.11662300
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11257636
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10866712
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10497365
81TCF4_22108803_ChIP-Seq_LS180_Human1.10236400
82SOX2_19829295_ChIP-Seq_ESCs_Human1.09546121
83NANOG_19829295_ChIP-Seq_ESCs_Human1.09546121
84TCF4_23295773_ChIP-Seq_U87_Human1.07821900
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.06635378
86AR_25329375_ChIP-Seq_VCAP_Human1.05562700
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04650465
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.04650465
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.03542769
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.03215469
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01210936
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00664881
93RUNX2_22187159_ChIP-Seq_PCA_Human0.99345152
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.98008845
95SRF_21415370_ChIP-Seq_HL-1_Mouse0.97687923
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97215176
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96307654
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96231333
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94163611
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93455193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.30309851
2MP0006292_abnormal_olfactory_placode3.12905867
3MP0002102_abnormal_ear_morphology2.67615929
4MP0010094_abnormal_chromosome_stability2.63887414
5MP0003787_abnormal_imprinting2.55639019
6MP0000569_abnormal_digit_pigmentation2.51650271
7MP0008058_abnormal_DNA_repair2.44797338
8MP0006072_abnormal_retinal_apoptosis2.31244628
9MP0003890_abnormal_embryonic-extraembry2.15347486
10MP0001293_anophthalmia2.13021295
11MP0002938_white_spotting2.11158522
12MP0003136_yellow_coat_color2.08239762
13MP0003693_abnormal_embryo_hatching2.08232978
14MP0003718_maternal_effect1.99646314
15MP0002638_abnormal_pupillary_reflex1.97857016
16MP0004133_heterotaxia1.90472599
17MP0005551_abnormal_eye_electrophysiolog1.89304942
18MP0003880_abnormal_central_pattern1.76176196
19MP0003195_calcinosis1.75804114
20MP0006276_abnormal_autonomic_nervous1.73511155
21MP0008057_abnormal_DNA_replication1.72006798
22MP0001529_abnormal_vocalization1.71424215
23MP0003121_genomic_imprinting1.70750951
24MP0005253_abnormal_eye_physiology1.67898271
25MP0001485_abnormal_pinna_reflex1.66735457
26MP0002736_abnormal_nociception_after1.64375115
27MP0001968_abnormal_touch/_nociception1.63637036
28MP0002234_abnormal_pharynx_morphology1.61360297
29MP0002837_dystrophic_cardiac_calcinosis1.55229676
30MP0003111_abnormal_nucleus_morphology1.54867775
31MP0002653_abnormal_ependyma_morphology1.54677542
32MP0003119_abnormal_digestive_system1.46716624
33MP0003567_abnormal_fetal_cardiomyocyte1.43278315
34MP0000631_abnormal_neuroendocrine_gland1.39762698
35MP0003937_abnormal_limbs/digits/tail_de1.38680837
36MP0004885_abnormal_endolymph1.38395206
37MP0005645_abnormal_hypothalamus_physiol1.36465232
38MP0000427_abnormal_hair_cycle1.35397879
39MP0003646_muscle_fatigue1.34810970
40MP0000778_abnormal_nervous_system1.34530091
41MP0008007_abnormal_cellular_replicative1.32750163
42MP0004957_abnormal_blastocyst_morpholog1.28995573
43MP0009697_abnormal_copulation1.25600648
44MP0009046_muscle_twitch1.25137555
45MP0008789_abnormal_olfactory_epithelium1.25035028
46MP0003077_abnormal_cell_cycle1.24943529
47MP0002751_abnormal_autonomic_nervous1.24873920
48MP0001188_hyperpigmentation1.23554523
49MP0004742_abnormal_vestibular_system1.22564605
50MP0005646_abnormal_pituitary_gland1.22073395
51MP0000647_abnormal_sebaceous_gland1.21289082
52MP0000372_irregular_coat_pigmentation1.19124966
53MP0008872_abnormal_physiological_respon1.16641672
54MP0001486_abnormal_startle_reflex1.16621403
55MP0004142_abnormal_muscle_tone1.16138929
56MP0002210_abnormal_sex_determination1.14780130
57MP0008932_abnormal_embryonic_tissue1.14051006
58MP0002272_abnormal_nervous_system1.13796144
59MP0001286_abnormal_eye_development1.13686033
60MP0002160_abnormal_reproductive_system1.12858179
61MP0003011_delayed_dark_adaptation1.12821426
62MP0005174_abnormal_tail_pigmentation1.11969234
63MP0005391_vision/eye_phenotype1.06844979
64MP0005195_abnormal_posterior_eye1.06269267
65MP0004147_increased_porphyrin_level1.03749474
66MP0001929_abnormal_gametogenesis1.03329327
67MP0005084_abnormal_gallbladder_morpholo1.03215541
68MP0005389_reproductive_system_phenotype1.02501930
69MP0001984_abnormal_olfaction1.02334858
70MP0009745_abnormal_behavioral_response1.02285043
71MP0003122_maternal_imprinting1.01732296
72MP0000049_abnormal_middle_ear1.00949509
73MP0005075_abnormal_melanosome_morpholog0.98652791
74MP0005499_abnormal_olfactory_system0.96577603
75MP0005394_taste/olfaction_phenotype0.96577603
76MP0002557_abnormal_social/conspecific_i0.95578762
77MP0008995_early_reproductive_senescence0.95543323
78MP0002163_abnormal_gland_morphology0.94437210
79MP0000653_abnormal_sex_gland0.93933665
80MP0001145_abnormal_male_reproductive0.93313621
81MP0001324_abnormal_eye_pigmentation0.90434860
82MP0000383_abnormal_hair_follicle0.90182206
83MP0010307_abnormal_tumor_latency0.90037913
84MP0001919_abnormal_reproductive_system0.89120511
85MP0002095_abnormal_skin_pigmentation0.88314490
86MP0002184_abnormal_innervation0.87307468
87MP0001986_abnormal_taste_sensitivity0.87080345
88MP0003698_abnormal_male_reproductive0.86870539
89MP0008875_abnormal_xenobiotic_pharmacok0.86839822
90MP0003786_premature_aging0.86687918
91MP0002752_abnormal_somatic_nervous0.85624484
92MP0005377_hearing/vestibular/ear_phenot0.85166718
93MP0003878_abnormal_ear_physiology0.85166718
94MP0005386_behavior/neurological_phenoty0.82588931
95MP0004924_abnormal_behavior0.82588931
96MP0001119_abnormal_female_reproductive0.80695930
97MP0003861_abnormal_nervous_system0.80644148
98MP0002876_abnormal_thyroid_physiology0.78990972
99MP0002572_abnormal_emotion/affect_behav0.78971124
100MP0002233_abnormal_nose_morphology0.78253412

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.01582311
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74673790
3Pancreatic fibrosis (HP:0100732)3.64717239
4Abnormality of midbrain morphology (HP:0002418)3.60029239
5Molar tooth sign on MRI (HP:0002419)3.60029239
6Abnormality of the labia minora (HP:0012880)3.51103147
7True hermaphroditism (HP:0010459)3.44832411
8Chromsome breakage (HP:0040012)3.43880215
9Meckel diverticulum (HP:0002245)3.25313302
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.20642868
11Abnormality of the ileum (HP:0001549)3.18239156
12Nephronophthisis (HP:0000090)3.09866469
13Colon cancer (HP:0003003)3.00445479
14Abnormality of the renal cortex (HP:0011035)2.96587815
15Renal cortical cysts (HP:0000803)2.87582690
16Abnormality of chromosome stability (HP:0003220)2.75774409
17Chronic hepatic failure (HP:0100626)2.63742992
18Volvulus (HP:0002580)2.59748965
19Abnormality of the renal medulla (HP:0100957)2.58916350
20Congenital stationary night blindness (HP:0007642)2.51752566
21Pendular nystagmus (HP:0012043)2.50638564
22Abnormality of the preputium (HP:0100587)2.43281791
23Medial flaring of the eyebrow (HP:0010747)2.38933436
24Abolished electroretinogram (ERG) (HP:0000550)2.37343849
25Sclerocornea (HP:0000647)2.35489156
26Birth length less than 3rd percentile (HP:0003561)2.35400206
27Inability to walk (HP:0002540)2.30182865
28Cystic liver disease (HP:0006706)2.28983650
29Abnormal biliary tract physiology (HP:0012439)2.24988291
30Bile duct proliferation (HP:0001408)2.24988291
31Progressive inability to walk (HP:0002505)2.24358676
32Sloping forehead (HP:0000340)2.21626097
33Anencephaly (HP:0002323)2.20185343
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.18618481
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.18310876
36Small intestinal stenosis (HP:0012848)2.16810864
37Duodenal stenosis (HP:0100867)2.16810864
38Patellar aplasia (HP:0006443)2.13477765
39Supernumerary spleens (HP:0009799)2.13305889
40Clubbing of toes (HP:0100760)2.12837804
41Abnormality of the carotid arteries (HP:0005344)2.12783130
42Triphalangeal thumb (HP:0001199)2.11319953
43Prostate neoplasm (HP:0100787)2.11032896
44Abnormality of the duodenum (HP:0002246)2.10543720
45Hyperglycinemia (HP:0002154)2.08958069
46Tubular atrophy (HP:0000092)2.08930383
47Intestinal atresia (HP:0011100)2.07202458
48Abnormality of alanine metabolism (HP:0010916)2.05628514
49Hyperalaninemia (HP:0003348)2.05628514
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05628514
51Type II lissencephaly (HP:0007260)2.04969847
52Oligodactyly (hands) (HP:0001180)2.02404108
53Aplasia/Hypoplasia of the patella (HP:0006498)2.02064529
54Lissencephaly (HP:0001339)2.01616968
55Dandy-Walker malformation (HP:0001305)2.00398074
56Congenital, generalized hypertrichosis (HP:0004540)1.99951151
57Preaxial hand polydactyly (HP:0001177)1.99349476
58Hyperglycinuria (HP:0003108)1.97078938
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96826914
60Postaxial foot polydactyly (HP:0001830)1.95397473
61Attenuation of retinal blood vessels (HP:0007843)1.94266417
62Ectopic kidney (HP:0000086)1.93838987
63Hypoplasia of the pons (HP:0012110)1.93409476
64Gait imbalance (HP:0002141)1.92933434
65Optic nerve hypoplasia (HP:0000609)1.92261412
66Congenital primary aphakia (HP:0007707)1.90961660
67Abnormality of the pons (HP:0007361)1.90129822
68Genital tract atresia (HP:0001827)1.84538719
69Short tibia (HP:0005736)1.83632207
70Oligohydramnios (HP:0001562)1.82179386
71Vaginal atresia (HP:0000148)1.80877784
72Anophthalmia (HP:0000528)1.79732690
73Nephrogenic diabetes insipidus (HP:0009806)1.78657159
74Methylmalonic acidemia (HP:0002912)1.78184253
75Male pseudohermaphroditism (HP:0000037)1.77829383
76Postaxial hand polydactyly (HP:0001162)1.77673784
77Septo-optic dysplasia (HP:0100842)1.77032574
78Astigmatism (HP:0000483)1.76708456
79Broad-based gait (HP:0002136)1.76702249
80Abnormality of glycine metabolism (HP:0010895)1.76055017
81Abnormality of serine family amino acid metabolism (HP:0010894)1.76055017
82Hyperventilation (HP:0002883)1.74773732
83Congenital hepatic fibrosis (HP:0002612)1.74697259
84Nephroblastoma (Wilms tumor) (HP:0002667)1.74209479
85Acute necrotizing encephalopathy (HP:0006965)1.73781841
86Bilateral microphthalmos (HP:0007633)1.73226766
87Fair hair (HP:0002286)1.72927713
88Acute encephalopathy (HP:0006846)1.72589989
89Short thumb (HP:0009778)1.71810758
90Absent thumb (HP:0009777)1.71515946
91Narrow forehead (HP:0000341)1.71342644
92Small hand (HP:0200055)1.70675442
93Abnormal drinking behavior (HP:0030082)1.68900860
94Polydipsia (HP:0001959)1.68900860
95Aganglionic megacolon (HP:0002251)1.68788035
96Neoplasm of the adrenal cortex (HP:0100641)1.67993925
97Embryonal renal neoplasm (HP:0011794)1.67086040
98Protruding tongue (HP:0010808)1.66471470
99Horseshoe kidney (HP:0000085)1.66466233
100Absent radius (HP:0003974)1.65532650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.51970837
2BMPR1B3.01786992
3FRK2.98810348
4WEE12.78347266
5WNK32.70624399
6CDC72.57667746
7NUAK12.54163395
8MKNK22.23156084
9SRPK12.17698174
10MAPK132.13112580
11PLK42.08584271
12TRIM282.05429755
13MAP4K22.02439432
14TLK12.00555021
15GRK11.90178670
16BUB11.85308903
17ADRBK21.84753777
18TNIK1.80495416
19ACVR1B1.79742336
20PLK31.78534100
21CASK1.76189934
22NEK11.73943808
23VRK11.70679556
24BRSK21.69748309
25MKNK11.56504112
26MAP3K41.52564086
27TSSK61.48696270
28DYRK21.47810733
29WNK41.46591276
30INSRR1.43002393
31TTK1.33147065
32PLK11.31886812
33PINK11.31548463
34PNCK1.27061280
35VRK21.24680797
36TAF11.18645122
37BCR1.15315737
38NEK21.14655640
39EIF2AK21.11162477
40TGFBR11.11158797
41STK31.11004709
42CHEK21.06662773
43ATR1.05019865
44PLK21.04326700
45MAP2K71.02093899
46CSNK1G11.00289083
47ERBB30.98373338
48EIF2AK30.97302725
49CSNK1G20.95030816
50TXK0.89558918
51CSNK1G30.89469203
52OXSR10.85697639
53PAK30.84782555
54MST40.84552953
55STK160.83999609
56CSNK1A1L0.81725398
57MARK10.80589468
58TAOK30.80460296
59STK390.80193467
60PKN10.72099310
61ATM0.70457208
62PRKCG0.69144018
63NLK0.67485544
64PRKCE0.63102197
65DYRK30.62040623
66AURKB0.61403349
67RPS6KA50.58728650
68BCKDK0.57967787
69TIE10.56409501
70NTRK20.55271619
71CCNB10.51431334
72ADRBK10.49835784
73FGFR20.49475891
74STK38L0.48800271
75CDK80.48769272
76MUSK0.48679738
77ERBB20.45953936
78ERBB40.45402283
79CDK70.45035663
80MAPKAPK50.42280718
81BRSK10.41508371
82AURKA0.40319028
83PASK0.40297763
84DAPK20.39515688
85TEC0.39270868
86CSNK1D0.38477145
87CHEK10.38323598
88FLT30.37898554
89CDK10.34793895
90CSNK1A10.33981252
91CAMKK20.33393447
92CSNK1E0.32802024
93CAMK2A0.32632807
94PRKDC0.32523801
95PRKCI0.31188111
96CSNK2A10.30043676
97EPHA40.28389832
98PBK0.27677146
99MINK10.27487411
100PRKACA0.27464097

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.60793991
2Fanconi anemia pathway_Homo sapiens_hsa034603.10734212
3RNA polymerase_Homo sapiens_hsa030202.84338331
4Protein export_Homo sapiens_hsa030602.70519945
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39263577
6Non-homologous end-joining_Homo sapiens_hsa034502.33540400
7Phototransduction_Homo sapiens_hsa047442.30312652
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24055699
9Basal transcription factors_Homo sapiens_hsa030222.22807738
10Mismatch repair_Homo sapiens_hsa034302.19325517
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08871887
12DNA replication_Homo sapiens_hsa030302.04093179
13Selenocompound metabolism_Homo sapiens_hsa004502.03935380
14Oxidative phosphorylation_Homo sapiens_hsa001901.97901138
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93577945
16RNA degradation_Homo sapiens_hsa030181.85853296
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85451711
18One carbon pool by folate_Homo sapiens_hsa006701.80976732
19Nitrogen metabolism_Homo sapiens_hsa009101.76550559
20Proteasome_Homo sapiens_hsa030501.75513367
21Parkinsons disease_Homo sapiens_hsa050121.63642270
22Butanoate metabolism_Homo sapiens_hsa006501.59677219
23Nicotine addiction_Homo sapiens_hsa050331.56385791
24Linoleic acid metabolism_Homo sapiens_hsa005911.56219118
25RNA transport_Homo sapiens_hsa030131.53305623
26Steroid biosynthesis_Homo sapiens_hsa001001.48019008
27Propanoate metabolism_Homo sapiens_hsa006401.44147753
28Cell cycle_Homo sapiens_hsa041101.42246684
29Base excision repair_Homo sapiens_hsa034101.38946242
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38610008
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36844278
32Nucleotide excision repair_Homo sapiens_hsa034201.36467751
33Spliceosome_Homo sapiens_hsa030401.35028535
34Pyrimidine metabolism_Homo sapiens_hsa002401.33328006
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32580706
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31802569
37Huntingtons disease_Homo sapiens_hsa050161.29769024
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28115600
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.25941377
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23134267
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17231149
42Caffeine metabolism_Homo sapiens_hsa002321.17123648
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16498656
44Purine metabolism_Homo sapiens_hsa002301.14718094
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.10177647
46Ribosome_Homo sapiens_hsa030101.01910763
47Ether lipid metabolism_Homo sapiens_hsa005650.99072637
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97484626
49Peroxisome_Homo sapiens_hsa041460.94058120
50p53 signaling pathway_Homo sapiens_hsa041150.93994949
51Tryptophan metabolism_Homo sapiens_hsa003800.90406711
52Alzheimers disease_Homo sapiens_hsa050100.90278850
53Cardiac muscle contraction_Homo sapiens_hsa042600.89311024
54Olfactory transduction_Homo sapiens_hsa047400.88746160
55Taste transduction_Homo sapiens_hsa047420.86565753
56Systemic lupus erythematosus_Homo sapiens_hsa053220.81520219
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79247732
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76442732
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.74865394
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74778425
61Basal cell carcinoma_Homo sapiens_hsa052170.73619731
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72636205
63Retinol metabolism_Homo sapiens_hsa008300.67047522
64Oocyte meiosis_Homo sapiens_hsa041140.66706614
65mRNA surveillance pathway_Homo sapiens_hsa030150.66662064
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65099286
67Alcoholism_Homo sapiens_hsa050340.64009522
68Regulation of autophagy_Homo sapiens_hsa041400.63636408
69Metabolic pathways_Homo sapiens_hsa011000.62551994
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61707548
71Hedgehog signaling pathway_Homo sapiens_hsa043400.61177957
72Chemical carcinogenesis_Homo sapiens_hsa052040.60386287
73Serotonergic synapse_Homo sapiens_hsa047260.59497995
74Morphine addiction_Homo sapiens_hsa050320.59382997
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57250727
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.54467707
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53054674
78Fatty acid elongation_Homo sapiens_hsa000620.51556579
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51402377
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50115835
81Fat digestion and absorption_Homo sapiens_hsa049750.50068439
82TGF-beta signaling pathway_Homo sapiens_hsa043500.49161989
83Vitamin B6 metabolism_Homo sapiens_hsa007500.47732370
84Arachidonic acid metabolism_Homo sapiens_hsa005900.46924290
85Vitamin digestion and absorption_Homo sapiens_hsa049770.46350470
86GABAergic synapse_Homo sapiens_hsa047270.46283884
87ABC transporters_Homo sapiens_hsa020100.45501323
88Hippo signaling pathway_Homo sapiens_hsa043900.44869786
89Primary immunodeficiency_Homo sapiens_hsa053400.41879073
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40648200
91Pyruvate metabolism_Homo sapiens_hsa006200.36888645
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35782852
93beta-Alanine metabolism_Homo sapiens_hsa004100.34202072
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34080466
95Fatty acid metabolism_Homo sapiens_hsa012120.33619473
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32047065
97Insulin secretion_Homo sapiens_hsa049110.31028450
98Folate biosynthesis_Homo sapiens_hsa007900.30915120
99Glutamatergic synapse_Homo sapiens_hsa047240.30498967
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.30060344

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