ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein polyglutamylation (GO:0018095)	6.52731580
2	water-soluble vitamin biosynthetic process (GO:0042364)	5.40769960
3	regulation of memory T cell differentiation (GO:0043380)	5.20634760
4	regulation of chromatin binding (GO:0035561)	4.79694412
5	piRNA metabolic process (GO:0034587)	4.79241581
6	regulation of cilium movement (GO:0003352)	4.61608889
7	nonmotile primary cilium assembly (GO:0035058)	4.47400721
8	response to pheromone (GO:0019236)	4.31545111
9	protein complex biogenesis (GO:0070271)	4.31364976
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.29797055
11	presynaptic membrane assembly (GO:0097105)	4.27682158
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.18402169
13	NADH dehydrogenase complex assembly (GO:0010257)	4.18402169
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.18402169
15	axoneme assembly (GO:0035082)	4.11515765
16	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.08110754
17	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	4.07831315
18	mitochondrial respiratory chain complex assembly (GO:0033108)	4.00940356
19	behavioral response to ethanol (GO:0048149)	3.90086378
20	ADP metabolic process (GO:0046031)	3.79217690
21	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.71205442
22	startle response (GO:0001964)	3.69202899
23	epithelial cilium movement (GO:0003351)	3.68216972
24	DNA methylation involved in gamete generation (GO:0043046)	3.63082026
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.59958468
26	cytochrome complex assembly (GO:0017004)	3.57052238
27	respiratory chain complex IV assembly (GO:0008535)	3.56117315
28	regulation of microtubule-based movement (GO:0060632)	3.53275247
29	positive regulation of T cell differentiation in thymus (GO:0033089)	3.50480759
30	presynaptic membrane organization (GO:0097090)	3.45439140
31	purine deoxyribonucleotide metabolic process (GO:0009151)	3.37604288
32	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.28382875
33	reflex (GO:0060004)	3.28345688
34	righting reflex (GO:0060013)	3.27479365
35	sequestering of actin monomers (GO:0042989)	3.26761111
36	glycerophospholipid catabolic process (GO:0046475)	3.23156103
37	adenosine metabolic process (GO:0046085)	3.21700098
38	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.20976401
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.20267146
40	short-chain fatty acid metabolic process (GO:0046459)	3.12389538
41	nucleoside diphosphate phosphorylation (GO:0006165)	3.05568240
42	response to nitrosative stress (GO:0051409)	3.03197427
43	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	3.02895118
44	auditory receptor cell stereocilium organization (GO:0060088)	2.98475255
45	kidney morphogenesis (GO:0060993)	2.95927472
46	ubiquinone biosynthetic process (GO:0006744)	2.92783910
47	neuronal action potential (GO:0019228)	2.91514772
48	molting cycle (GO:0042303)	2.90129342
49	hair cycle (GO:0042633)	2.90129342
50	neuron cell-cell adhesion (GO:0007158)	2.89501111
51	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.88375010
52	ganglion development (GO:0061548)	2.87535910
53	regulation of appetite (GO:0032098)	2.82856796
54	inositol phosphate catabolic process (GO:0071545)	2.82767767
55	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.82430376
56	ATP synthesis coupled proton transport (GO:0015986)	2.82430376
57	positive regulation of growth hormone secretion (GO:0060124)	2.80356728
58	regulation of activation of Janus kinase activity (GO:0010533)	2.77001967
59	protein localization to synapse (GO:0035418)	2.76340127
60	positive regulation of cell fate commitment (GO:0010455)	2.76322602
61	positive regulation of fatty acid transport (GO:2000193)	2.75998558
62	protein-cofactor linkage (GO:0018065)	2.70459306
63	replication fork processing (GO:0031297)	2.69690644
64	cellular ketone body metabolic process (GO:0046950)	2.69143388
65	ubiquinone metabolic process (GO:0006743)	2.69057111
66	heme transport (GO:0015886)	2.68197416
67	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.67702027
68	AMP metabolic process (GO:0046033)	2.66397997
69	nitric oxide mediated signal transduction (GO:0007263)	2.66293002
70	activated T cell proliferation (GO:0050798)	2.64923752
71	positive regulation of neurotransmitter secretion (GO:0001956)	2.63002759
72	polyol catabolic process (GO:0046174)	2.62331850
73	basic amino acid transport (GO:0015802)	2.60757326
74	cilium movement (GO:0003341)	2.59543158
75	L-fucose metabolic process (GO:0042354)	2.59246937
76	L-fucose catabolic process (GO:0042355)	2.59246937
77	fucose catabolic process (GO:0019317)	2.59246937
78	sperm motility (GO:0030317)	2.59150290
79	S-adenosylmethionine metabolic process (GO:0046500)	2.58839756
80	regulation of hexokinase activity (GO:1903299)	2.58049496
81	regulation of glucokinase activity (GO:0033131)	2.58049496
82	rRNA modification (GO:0000154)	2.57632959
83	neurotransmitter-gated ion channel clustering (GO:0072578)	2.57431146
84	iron coordination entity transport (GO:1901678)	2.57149267
85	positive regulation of T-helper 1 type immune response (GO:0002827)	2.57092769
86	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.56070501
87	GPI anchor metabolic process (GO:0006505)	2.55506383
88	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.55033497
89	negative regulation of mast cell activation (GO:0033004)	2.52788495
90	membrane protein intracellular domain proteolysis (GO:0031293)	2.52643309
91	photoreceptor cell maintenance (GO:0045494)	2.50835099
92	ATP biosynthetic process (GO:0006754)	2.49710052
93	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.49601350
94	L-ascorbic acid metabolic process (GO:0019852)	2.49378028
95	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.48989971
96	inositol phosphate dephosphorylation (GO:0046855)	2.48989971
97	positive regulation of insulin secretion (GO:0032024)	2.48898496
98	atrial cardiac muscle cell action potential (GO:0086014)	2.45971173
99	negative regulation of appetite (GO:0032099)	2.45026561
100	negative regulation of response to food (GO:0032096)	2.45026561

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.40962115
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.87787285
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78471124
4	VDR_22108803_ChIP-Seq_LS180_Human	3.48063207
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.27141806
6	TAF15_26573619_Chip-Seq_HEK293_Human	3.08995657
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71922119
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.67642191
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16263303
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15527964
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10088942
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.02321208
13	EWS_26573619_Chip-Seq_HEK293_Human	2.00265358
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.94927232
15	FUS_26573619_Chip-Seq_HEK293_Human	1.89589000
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.88895160
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88583137
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.83013745
19	P300_19829295_ChIP-Seq_ESCs_Human	1.81589930
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.76602061
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.75168275
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73108351
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69734891
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.66299251
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.66103009
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.66103009
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.65733007
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.60043306
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58076985
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.56461655
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.55768387
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.55514775
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.54463019
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.52043180
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50258955
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50258955
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48778642
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47270192
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44916280
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44471931
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37812339
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37812339
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35950704
44	TCF4_23295773_ChIP-Seq_U87_Human	1.33896892
45	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33799212
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32132976
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32019172
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31183929
49	STAT3_23295773_ChIP-Seq_U87_Human	1.29595768
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27756928
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27536179
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27120133
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26878318
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25998130
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25492320
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25492320
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25450350
58	AR_25329375_ChIP-Seq_VCAP_Human	1.24563893
59	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.23178267
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.21718850
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19941811
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19075662
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18691191
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.18051350
65	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17324323
66	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.16939855
67	NCOR_22424771_ChIP-Seq_293T_Human	1.16318862
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16235269
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.15036591
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14477805
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14305512
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14158917
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12510572
74	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12390052
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.11692183
76	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.10955879
77	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.09321715
78	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08411504
79	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.08319155
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08181274
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07383007
82	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06679038
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06420846
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.05789499
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05429504
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.04175162
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03492706
88	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.02431103
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01599853
90	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01341888
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01242221
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00912075
93	CDX2_22108803_ChIP-Seq_LS180_Human	1.00566501
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98987861
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96813176
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96019938
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.95834015
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95501176
99	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94875627
100	AR_20517297_ChIP-Seq_VCAP_Human	0.94512118

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	7.57274970
2	MP0003880_abnormal_central_pattern	4.60114598
3	MP0005645_abnormal_hypothalamus_physiol	3.56040039
4	MP0004742_abnormal_vestibular_system	3.15207065
5	MP0008789_abnormal_olfactory_epithelium	2.89255834
6	MP0003195_calcinosis	2.66059375
7	MP0001529_abnormal_vocalization	2.53478358
8	MP0004885_abnormal_endolymph	2.41898069
9	MP0005394_taste/olfaction_phenotype	2.35760851
10	MP0005499_abnormal_olfactory_system	2.35760851
11	MP0006276_abnormal_autonomic_nervous	2.18956990
12	MP0005423_abnormal_somatic_nervous	2.14166340
13	MP0008877_abnormal_DNA_methylation	2.00837785
14	MP0001486_abnormal_startle_reflex	1.99931537
15	MP0001188_hyperpigmentation	1.92328830
16	MP0001968_abnormal_touch/_nociception	1.90682222
17	MP0006072_abnormal_retinal_apoptosis	1.83146237
18	MP0005167_abnormal_blood-brain_barrier	1.79125075
19	MP0005084_abnormal_gallbladder_morpholo	1.74195996
20	MP0002160_abnormal_reproductive_system	1.70206112
21	MP0002272_abnormal_nervous_system	1.69449608
22	MP0005174_abnormal_tail_pigmentation	1.68067867
23	MP0002163_abnormal_gland_morphology	1.67762918
24	MP0004924_abnormal_behavior	1.67740292
25	MP0005386_behavior/neurological_phenoty	1.67740292
26	MP0001986_abnormal_taste_sensitivity	1.67178991
27	MP0002557_abnormal_social/conspecific_i	1.61723247
28	MP0002102_abnormal_ear_morphology	1.60728761
29	MP0002837_dystrophic_cardiac_calcinosis	1.53100542
30	MP0004142_abnormal_muscle_tone	1.50938179
31	MP0005379_endocrine/exocrine_gland_phen	1.48682914
32	MP0002876_abnormal_thyroid_physiology	1.48089798
33	MP0002138_abnormal_hepatobiliary_system	1.45061659
34	MP0008875_abnormal_xenobiotic_pharmacok	1.42116921
35	MP0001542_abnormal_bone_strength	1.41552915
36	MP0005389_reproductive_system_phenotype	1.40233643
37	MP0005551_abnormal_eye_electrophysiolog	1.38902161
38	MP0002735_abnormal_chemical_nociception	1.35416488
39	MP0002736_abnormal_nociception_after	1.35334981
40	MP0005646_abnormal_pituitary_gland	1.28079340
41	MP0001970_abnormal_pain_threshold	1.25418413
42	MP0003806_abnormal_nucleotide_metabolis	1.24745544
43	MP0009745_abnormal_behavioral_response	1.24713167
44	MP0000015_abnormal_ear_pigmentation	1.23799353
45	MP0010368_abnormal_lymphatic_system	1.20563226
46	MP0003787_abnormal_imprinting	1.18551940
47	MP0001440_abnormal_grooming_behavior	1.18187890
48	MP0004147_increased_porphyrin_level	1.15639298
49	MP0002734_abnormal_mechanical_nocicepti	1.14907528
50	MP0001984_abnormal_olfaction	1.14551087
51	MP0005410_abnormal_fertilization	1.11337729
52	MP0002733_abnormal_thermal_nociception	1.10030713
53	MP0002184_abnormal_innervation	1.05660251
54	MP0005253_abnormal_eye_physiology	1.05583935
55	MP0001764_abnormal_homeostasis	1.05356375
56	MP0003633_abnormal_nervous_system	1.04695740
57	MP0002067_abnormal_sensory_capabilities	1.02642450
58	MP0002572_abnormal_emotion/affect_behav	1.02511507
59	MP0001485_abnormal_pinna_reflex	1.02180760
60	MP0000427_abnormal_hair_cycle	1.02102704
61	MP0002928_abnormal_bile_duct	1.01685392
62	MP0001963_abnormal_hearing_physiology	1.00603609
63	MP0002254_reproductive_system_inflammat	1.00053652
64	MP0001905_abnormal_dopamine_level	0.95648217
65	MP0004043_abnormal_pH_regulation	0.94190121
66	MP0002909_abnormal_adrenal_gland	0.93191562
67	MP0006054_spinal_hemorrhage	0.93098210
68	MP0003635_abnormal_synaptic_transmissio	0.91930779
69	MP0000026_abnormal_inner_ear	0.88619204
70	MP0005220_abnormal_exocrine_pancreas	0.87510831
71	MP0001501_abnormal_sleep_pattern	0.87111666
72	MP0008872_abnormal_physiological_respon	0.86897984
73	MP0003879_abnormal_hair_cell	0.86631772
74	MP0008995_early_reproductive_senescence	0.85561821
75	MP0000003_abnormal_adipose_tissue	0.84697326
76	MP0002693_abnormal_pancreas_physiology	0.82799396
77	MP0002229_neurodegeneration	0.81311310
78	MP0009046_muscle_twitch	0.79841243
79	MP0002139_abnormal_hepatobiliary_system	0.78747873
80	MP0003698_abnormal_male_reproductive	0.77963386
81	MP0004145_abnormal_muscle_electrophysio	0.76571824
82	MP0003878_abnormal_ear_physiology	0.75724103
83	MP0005377_hearing/vestibular/ear_phenot	0.75724103
84	MP0000013_abnormal_adipose_tissue	0.75439891
85	MP0002752_abnormal_somatic_nervous	0.73565731
86	MP0005085_abnormal_gallbladder_physiolo	0.72808830
87	MP0003638_abnormal_response/metabolism_	0.72551350
88	MP0003646_muscle_fatigue	0.72018427
89	MP0008058_abnormal_DNA_repair	0.71402191
90	MP0002064_seizures	0.70429610
91	MP0006292_abnormal_olfactory_placode	0.70317291
92	MP0003631_nervous_system_phenotype	0.69137243
93	MP0001664_abnormal_digestion	0.67971909
94	MP0003122_maternal_imprinting	0.67533271
95	MP0001919_abnormal_reproductive_system	0.67041711
96	MP0006035_abnormal_mitochondrial_morpho	0.66653413
97	MP0002822_catalepsy	0.66362014
98	MP0001944_abnormal_pancreas_morphology	0.64773541
99	MP0002210_abnormal_sex_determination	0.62487669
100	MP0005448_abnormal_energy_balance	0.61139920

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Methylmalonic acidemia (HP:0002912)	4.74207436
2	Hypothermia (HP:0002045)	4.04170689
3	Congenital sensorineural hearing impairment (HP:0008527)	3.92093436
4	Methylmalonic aciduria (HP:0012120)	3.50828090
5	Abnormality of vitamin B metabolism (HP:0004340)	3.49734942
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.31053572
7	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.25784474
8	Abnormality of midbrain morphology (HP:0002418)	3.16628597
9	Molar tooth sign on MRI (HP:0002419)	3.16628597
10	Febrile seizures (HP:0002373)	3.07884421
11	Medial flaring of the eyebrow (HP:0010747)	3.06509110
12	Abolished electroretinogram (ERG) (HP:0000550)	3.02887782
13	Pancreatic cysts (HP:0001737)	2.89042514
14	Large for gestational age (HP:0001520)	2.81226637
15	Hyperinsulinemic hypoglycemia (HP:0000825)	2.72227888
16	Acute necrotizing encephalopathy (HP:0006965)	2.68277148
17	True hermaphroditism (HP:0010459)	2.65936561
18	Polyphagia (HP:0002591)	2.61971587
19	Absent/shortened dynein arms (HP:0200106)	2.60714641
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.60714641
21	Abnormality of alanine metabolism (HP:0010916)	2.60545245
22	Hyperalaninemia (HP:0003348)	2.60545245
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.60545245
24	Dysdiadochokinesis (HP:0002075)	2.59973315
25	Progressive macrocephaly (HP:0004481)	2.57830333
26	Abnormality of vitamin metabolism (HP:0100508)	2.55771959
27	Nephronophthisis (HP:0000090)	2.55505847
28	Gait imbalance (HP:0002141)	2.54672022
29	Hyperglycinemia (HP:0002154)	2.50480483
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.47113184
31	3-Methylglutaconic aciduria (HP:0003535)	2.46857431
32	Congenital primary aphakia (HP:0007707)	2.44528804
33	Ketoacidosis (HP:0001993)	2.44318746
34	Pancreatic fibrosis (HP:0100732)	2.43476581
35	Thyroiditis (HP:0100646)	2.42498299
36	Pendular nystagmus (HP:0012043)	2.42089070
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.37476872
38	Hepatocellular necrosis (HP:0001404)	2.33758863
39	Mitochondrial inheritance (HP:0001427)	2.32981241
40	Ketosis (HP:0001946)	2.30667369
41	Rhinitis (HP:0012384)	2.28319396
42	Acute encephalopathy (HP:0006846)	2.27136164
43	Chronic bronchitis (HP:0004469)	2.25300091
44	Congenital, generalized hypertrichosis (HP:0004540)	2.24666713
45	Hepatic necrosis (HP:0002605)	2.23320174
46	Late onset (HP:0003584)	2.22588289
47	Hypochromic microcytic anemia (HP:0004840)	2.20741636
48	Type II lissencephaly (HP:0007260)	2.20381155
49	Abnormality of serine family amino acid metabolism (HP:0010894)	2.19690255
50	Abnormality of glycine metabolism (HP:0010895)	2.19690255
51	Optic neuritis (HP:0100653)	2.16320568
52	Retrobulbar optic neuritis (HP:0100654)	2.16320568
53	Increased CSF lactate (HP:0002490)	2.15617888
54	Nephrogenic diabetes insipidus (HP:0009806)	2.12914739
55	Abnormality of the renal medulla (HP:0100957)	2.11371210
56	Abnormality of the renal cortex (HP:0011035)	2.10407607
57	Attenuation of retinal blood vessels (HP:0007843)	2.08687174
58	Adactyly (HP:0009776)	2.08299248
59	Agitation (HP:0000713)	2.07594408
60	Retinal atrophy (HP:0001105)	2.06635548
61	Limb dystonia (HP:0002451)	2.06417726
62	Long foot (HP:0001833)	2.06226061
63	Genital tract atresia (HP:0001827)	2.04207060
64	Retinal dysplasia (HP:0007973)	2.03895804
65	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.03004743
66	Hypoplasia of the fovea (HP:0007750)	2.03004743
67	Polyuria (HP:0000103)	2.02058874
68	Abnormal respiratory epithelium morphology (HP:0012253)	2.01522965
69	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01522965
70	Abnormal drinking behavior (HP:0030082)	2.00547868
71	Polydipsia (HP:0001959)	2.00547868
72	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.99956068
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.99956068
74	Vaginal atresia (HP:0000148)	1.97394604
75	Hyperventilation (HP:0002883)	1.94808720
76	Atonic seizures (HP:0010819)	1.94264581
77	Congenital stationary night blindness (HP:0007642)	1.90800771
78	Increased serum lactate (HP:0002151)	1.87965102
79	Abnormality of serum amino acid levels (HP:0003112)	1.86105699
80	Intention tremor (HP:0002080)	1.85929329
81	Abnormality of urine glucose concentration (HP:0011016)	1.85805956
82	Glycosuria (HP:0003076)	1.85805956
83	Cystic liver disease (HP:0006706)	1.85607288
84	Renal Fanconi syndrome (HP:0001994)	1.82881389
85	Hypomagnesemia (HP:0002917)	1.82826132
86	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.78967636
87	Dicarboxylic aciduria (HP:0003215)	1.78967636
88	Hemiparesis (HP:0001269)	1.76220408
89	Increased hepatocellular lipid droplets (HP:0006565)	1.74209116
90	Furrowed tongue (HP:0000221)	1.72186756
91	Basal ganglia calcification (HP:0002135)	1.72094471
92	Muscular hypotonia of the trunk (HP:0008936)	1.71853154
93	Abnormality of eosinophils (HP:0001879)	1.71650974
94	Intestinal atresia (HP:0011100)	1.70707259
95	Duplicated collecting system (HP:0000081)	1.70403137
96	Pancreatic islet-cell hyperplasia (HP:0004510)	1.69786809
97	Delayed CNS myelination (HP:0002188)	1.69487780
98	Fetal akinesia sequence (HP:0001989)	1.67787945
99	Abnormal urine output (HP:0012590)	1.67403781
100	Lipid accumulation in hepatocytes (HP:0006561)	1.67289456

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.37821581
2	FRK	4.28292354
3	MAP4K2	3.57892255
4	PINK1	3.22356255
5	TAOK1	2.70663203
6	ADRBK2	2.62249147
7	TIE1	2.51537646
8	DYRK2	2.32464994
9	EPHA3	2.28665290
10	DYRK3	2.19979758
11	PNCK	2.15841015
12	BCR	2.00903584
13	PLK4	1.84888715
14	MAP3K9	1.84162852
15	NEK6	1.73050796
16	WNK3	1.69437704
17	PHKG2	1.69064580
18	PHKG1	1.69064580
19	TAOK3	1.66647365
20	MAPK13	1.65303748
21	NUAK1	1.62295368
22	VRK1	1.60674459
23	VRK2	1.53429188
24	FGFR2	1.47456683
25	PAK3	1.45374854
26	MST4	1.38723868
27	GRK1	1.31054461
28	EPHB1	1.29909965
29	BMPR1B	1.29545641
30	STK38L	1.27036282
31	GRK7	1.26406108
32	PASK	1.21375842
33	MARK1	1.19450748
34	ZAK	1.14661076
35	INSRR	1.14318074
36	CSNK1A1L	1.13656416
37	PRKCI	1.11622923
38	DAPK2	1.10501532
39	CSNK1G2	1.09744026
40	CSNK1G3	1.08000571
41	MAP3K4	1.02759311
42	PRKCE	1.02490315
43	HIPK2	1.01290011
44	TXK	0.96441449
45	CHUK	0.95471351
46	PRKCG	0.94482478
47	CASK	0.94477556
48	IRAK1	0.91179017
49	CSNK1G1	0.90201651
50	RPS6KA4	0.87500137
51	IKBKB	0.86372895
52	AKT3	0.84011856
53	FER	0.83852825
54	KIT	0.75073479
55	TSSK6	0.73601335
56	TLK1	0.73046576
57	STK11	0.72938756
58	RPS6KA5	0.71920121
59	MAP2K7	0.70770189
60	PAK6	0.70205629
61	ADRBK1	0.68481932
62	UHMK1	0.66944135
63	NLK	0.64872169
64	CAMK2D	0.64438910
65	OXSR1	0.64200890
66	MKNK2	0.61537742
67	PLK3	0.60746783
68	MINK1	0.56829461
69	STK3	0.54096671
70	CAMK2A	0.53841827
71	EIF2AK2	0.53150265
72	IRAK4	0.52859173
73	TGFBR1	0.50518533
74	BRAF	0.50423221
75	MKNK1	0.48688928
76	DAPK1	0.47889315
77	NTRK2	0.46650000
78	GRK5	0.45945790
79	TGFBR2	0.43648318
80	DYRK1A	0.42134159
81	CAMK2G	0.41513896
82	CSNK1A1	0.40313102
83	FGFR3	0.40090618
84	PRKACA	0.36006237
85	CAMK1G	0.35477003
86	PLK2	0.35370198
87	TNIK	0.34442090
88	CAMK2B	0.33471857
89	OBSCN	0.32618567
90	PRKACB	0.32282407
91	CAMK1	0.31439968
92	EPHA4	0.30012532
93	PRKCB	0.28515207
94	PRKCA	0.27693135
95	SGK494	0.26977843
96	SGK223	0.26977843
97	SIK2	0.26089138
98	PRKG1	0.25070293
99	SRPK1	0.23375723
100	PDK2	0.22823501

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.67617572
2	Nicotine addiction_Homo sapiens_hsa05033	3.17785782
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.74313128
4	Phototransduction_Homo sapiens_hsa04744	2.70810151
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58274289
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31683191
7	Propanoate metabolism_Homo sapiens_hsa00640	1.94892642
8	Protein export_Homo sapiens_hsa03060	1.90214715
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.88084502
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.78076785
11	Insulin secretion_Homo sapiens_hsa04911	1.76846230
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.73174554
13	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.71090224
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70235817
15	RNA polymerase_Homo sapiens_hsa03020	1.69829984
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61671353
17	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.59547707
18	Circadian entrainment_Homo sapiens_hsa04713	1.58828166
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.58611666
20	Parkinsons disease_Homo sapiens_hsa05012	1.58275573
21	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.57835062
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56032141
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55204889
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53756236
25	ABC transporters_Homo sapiens_hsa02010	1.52916663
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.39817110
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.38139500
28	Taste transduction_Homo sapiens_hsa04742	1.36282501
29	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.36149576
30	Butanoate metabolism_Homo sapiens_hsa00650	1.32760579
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.26109896
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.24248927
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21923830
34	Glutamatergic synapse_Homo sapiens_hsa04724	1.17584148
35	GABAergic synapse_Homo sapiens_hsa04727	1.16938876
36	Alzheimers disease_Homo sapiens_hsa05010	1.15313620
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09837421
38	Sulfur metabolism_Homo sapiens_hsa00920	1.09721179
39	Amphetamine addiction_Homo sapiens_hsa05031	1.09592216
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.09522783
41	Morphine addiction_Homo sapiens_hsa05032	1.08228821
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.07209524
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.05804401
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05181080
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.05152832
46	Glutathione metabolism_Homo sapiens_hsa00480	1.04749197
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04616789
48	Cocaine addiction_Homo sapiens_hsa05030	1.04032460
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03930735
50	RNA degradation_Homo sapiens_hsa03018	1.02786917
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.01288587
52	Olfactory transduction_Homo sapiens_hsa04740	0.98734866
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97268484
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97261232
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.94161490
56	Regulation of autophagy_Homo sapiens_hsa04140	0.93376547
57	Peroxisome_Homo sapiens_hsa04146	0.90863144
58	Purine metabolism_Homo sapiens_hsa00230	0.89727232
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88753730
60	Huntingtons disease_Homo sapiens_hsa05016	0.86933614
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.85673052
62	Retinol metabolism_Homo sapiens_hsa00830	0.85026586
63	Folate biosynthesis_Homo sapiens_hsa00790	0.84414554
64	Salivary secretion_Homo sapiens_hsa04970	0.82803392
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.80497581
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.77714349
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.75965057
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.75782378
69	Fatty acid elongation_Homo sapiens_hsa00062	0.74771935
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73593389
71	Caffeine metabolism_Homo sapiens_hsa00232	0.72156772
72	Serotonergic synapse_Homo sapiens_hsa04726	0.71868691
73	Metabolic pathways_Homo sapiens_hsa01100	0.70518800
74	Renin secretion_Homo sapiens_hsa04924	0.70459155
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.70394540
76	Basal transcription factors_Homo sapiens_hsa03022	0.68259122
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.65610603
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.65250392
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64542551
80	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.63480269
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.61099969
82	Mineral absorption_Homo sapiens_hsa04978	0.60169138
83	Antigen processing and presentation_Homo sapiens_hsa04612	0.59516862
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59234018
85	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.58629175
86	Graft-versus-host disease_Homo sapiens_hsa05332	0.56660265
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.55619770
88	Gastric acid secretion_Homo sapiens_hsa04971	0.55172519
89	Asthma_Homo sapiens_hsa05310	0.52965011
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.48405473
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47877903
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47590247
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.46001600
94	Legionellosis_Homo sapiens_hsa05134	0.44753333
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44401215
96	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44210634
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.43773711
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.41504124
99	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.38017123
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.37570635

ZNF725P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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