ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.52297989
2	response to pheromone (GO:0019236)	4.46170284
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.25227980
4	DNA deamination (GO:0045006)	4.17290018
5	L-fucose catabolic process (GO:0042355)	4.00740055
6	fucose catabolic process (GO:0019317)	4.00740055
7	L-fucose metabolic process (GO:0042354)	4.00740055
8	negative regulation of telomere maintenance (GO:0032205)	3.99424929
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.66284166
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49797022
11	NADH dehydrogenase complex assembly (GO:0010257)	3.49797022
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49797022
13	protein complex biogenesis (GO:0070271)	3.49748593
14	platelet dense granule organization (GO:0060155)	3.47714599
15	cellular ketone body metabolic process (GO:0046950)	3.47689795
16	kidney morphogenesis (GO:0060993)	3.44958364
17	epithelial cilium movement (GO:0003351)	3.44211761
18	respiratory chain complex IV assembly (GO:0008535)	3.36812559
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.34268087
20	piRNA metabolic process (GO:0034587)	3.32585363
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.25875235
22	pseudouridine synthesis (GO:0001522)	3.24939470
23	indolalkylamine metabolic process (GO:0006586)	3.22381596
24	tryptophan catabolic process (GO:0006569)	3.19909877
25	indole-containing compound catabolic process (GO:0042436)	3.19909877
26	indolalkylamine catabolic process (GO:0046218)	3.19909877
27	replication fork processing (GO:0031297)	3.17087782
28	ketone body metabolic process (GO:1902224)	3.12236995
29	protein-cofactor linkage (GO:0018065)	3.08914977
30	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.98764795
31	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97511015
32	kynurenine metabolic process (GO:0070189)	2.97071553
33	cytochrome complex assembly (GO:0017004)	2.95996564
34	sulfation (GO:0051923)	2.95584942
35	mannosylation (GO:0097502)	2.94313218
36	nonmotile primary cilium assembly (GO:0035058)	2.94005809
37	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.93263842
38	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.93263842
39	regulation of translation, ncRNA-mediated (GO:0045974)	2.93263842
40	ATP synthesis coupled proton transport (GO:0015986)	2.92631216
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92631216
42	nephron tubule morphogenesis (GO:0072078)	2.91321117
43	nephron epithelium morphogenesis (GO:0072088)	2.91321117
44	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86343396
45	reciprocal meiotic recombination (GO:0007131)	2.83721936
46	reciprocal DNA recombination (GO:0035825)	2.83721936
47	centriole replication (GO:0007099)	2.83625187
48	neural tube formation (GO:0001841)	2.82409978
49	cilium movement (GO:0003341)	2.81722569
50	detection of light stimulus involved in sensory perception (GO:0050962)	2.80925022
51	detection of light stimulus involved in visual perception (GO:0050908)	2.80925022
52	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.78692722
53	regulation of telomere maintenance (GO:0032204)	2.78280134
54	cornea development in camera-type eye (GO:0061303)	2.77301480
55	protein polyglutamylation (GO:0018095)	2.75780356
56	recombinational repair (GO:0000725)	2.75246683
57	axoneme assembly (GO:0035082)	2.75197244
58	tryptophan metabolic process (GO:0006568)	2.73674265
59	double-strand break repair via homologous recombination (GO:0000724)	2.73530628
60	neuronal action potential (GO:0019228)	2.70646065
61	regulation of posttranscriptional gene silencing (GO:0060147)	2.69527572
62	regulation of gene silencing by miRNA (GO:0060964)	2.69527572
63	regulation of gene silencing by RNA (GO:0060966)	2.69527572
64	cilium morphogenesis (GO:0060271)	2.67042209
65	male meiosis I (GO:0007141)	2.66233379
66	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.65689354
67	protein K6-linked ubiquitination (GO:0085020)	2.65204609
68	S-adenosylmethionine metabolic process (GO:0046500)	2.65021481
69	ubiquinone biosynthetic process (GO:0006744)	2.64412076
70	regulation of cilium movement (GO:0003352)	2.64097916
71	somite development (GO:0061053)	2.60952006
72	regulation of mesoderm development (GO:2000380)	2.60708084
73	DNA double-strand break processing (GO:0000729)	2.60340825
74	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.59632192
75	regulation of glucokinase activity (GO:0033131)	2.59592115
76	regulation of hexokinase activity (GO:1903299)	2.59592115
77	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.59169277
78	indole-containing compound metabolic process (GO:0042430)	2.58915132
79	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.58033732
80	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.58033732
81	negative regulation of mast cell activation (GO:0033004)	2.57011638
82	rhodopsin mediated signaling pathway (GO:0016056)	2.56674639
83	synapsis (GO:0007129)	2.55394998
84	cilium organization (GO:0044782)	2.50363295
85	ubiquinone metabolic process (GO:0006743)	2.50012512
86	rRNA catabolic process (GO:0016075)	2.48475265
87	DNA methylation involved in gamete generation (GO:0043046)	2.47999771
88	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.47395441
89	reflex (GO:0060004)	2.45594540
90	peptidyl-histidine modification (GO:0018202)	2.44598605
91	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.44363296
92	regulation of meiosis I (GO:0060631)	2.44297702
93	resolution of meiotic recombination intermediates (GO:0000712)	2.44079911
94	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.43469907
95	meiotic chromosome segregation (GO:0045132)	2.43073765
96	retinal cone cell development (GO:0046549)	2.43017122
97	spinal cord motor neuron differentiation (GO:0021522)	2.41243468
98	protein neddylation (GO:0045116)	2.41013233
99	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.40907969
100	cilium assembly (GO:0042384)	2.40108191

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.22403396
2	VDR_22108803_ChIP-Seq_LS180_Human	3.35826177
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.56532097
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53078370
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.52455952
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.51053524
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48039477
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47126592
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39063320
10	EWS_26573619_Chip-Seq_HEK293_Human	2.38193596
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31243753
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.30994872
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29097724
14	FUS_26573619_Chip-Seq_HEK293_Human	2.27156529
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18426530
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.18392532
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11869170
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.04961763
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04190061
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.02533686
21	ER_23166858_ChIP-Seq_MCF-7_Human	2.00591606
22	P300_19829295_ChIP-Seq_ESCs_Human	1.99549668
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90303222
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.86613597
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.83332920
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83317247
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79633286
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.74190318
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67740884
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.63249131
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55380150
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.53432485
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.49460197
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47609823
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.44169472
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43918594
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43675155
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43675155
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43153479
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.41369984
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.41369984
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40366305
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39441348
44	AR_25329375_ChIP-Seq_VCAP_Human	1.38286242
45	STAT3_23295773_ChIP-Seq_U87_Human	1.37534579
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.35733895
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35687537
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34997086
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33352174
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.33352174
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32593044
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32593044
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30918822
54	TCF4_23295773_ChIP-Seq_U87_Human	1.29664405
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28522519
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28320391
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27291999
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.26800689
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25562049
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.24865136
61	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.24589827
62	AR_20517297_ChIP-Seq_VCAP_Human	1.23518608
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22963474
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22390257
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21674526
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21160359
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20408940
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19311953
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19003134
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18105173
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16752111
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16684811
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.15854382
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15417333
75	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15344788
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15010212
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14153376
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13703414
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13617215
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10227306
81	NCOR_22424771_ChIP-Seq_293T_Human	1.07024895
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05998340
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05299627
84	AR_21572438_ChIP-Seq_LNCaP_Human	1.05260237
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04797521
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03919782
87	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.03768939
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02076706
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01448949
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00859357
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00563960
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00500768
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00319082
94	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00276902
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99704039
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99401368
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96214162
98	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96081002
99	FOXP3_21729870_ChIP-Seq_TREG_Human	0.92872428
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.91982537

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	2.91865264
2	MP0008877_abnormal_DNA_methylation	2.88628860
3	MP0004147_increased_porphyrin_level	2.79777260
4	MP0003195_calcinosis	2.55393423
5	MP0000569_abnormal_digit_pigmentation	2.53841656
6	MP0006292_abnormal_olfactory_placode	2.40270776
7	MP0005551_abnormal_eye_electrophysiolog	2.30857575
8	MP0002102_abnormal_ear_morphology	2.25979586
9	MP0002938_white_spotting	2.18739623
10	MP0006072_abnormal_retinal_apoptosis	2.07770500
11	MP0001968_abnormal_touch/_nociception	2.02003677
12	MP0002638_abnormal_pupillary_reflex	2.00660981
13	MP0008872_abnormal_physiological_respon	1.99710421
14	MP0002837_dystrophic_cardiac_calcinosis	1.96557745
15	MP0005645_abnormal_hypothalamus_physiol	1.96304154
16	MP0004885_abnormal_endolymph	1.86157423
17	MP0004043_abnormal_pH_regulation	1.85920339
18	MP0002653_abnormal_ependyma_morphology	1.84560184
19	MP0003646_muscle_fatigue	1.80901132
20	MP0004142_abnormal_muscle_tone	1.79142809
21	MP0009046_muscle_twitch	1.77556311
22	MP0005253_abnormal_eye_physiology	1.76614928
23	MP0001485_abnormal_pinna_reflex	1.75817719
24	MP0002736_abnormal_nociception_after	1.73729692
25	MP0005174_abnormal_tail_pigmentation	1.72002268
26	MP0002876_abnormal_thyroid_physiology	1.71185132
27	MP0008058_abnormal_DNA_repair	1.67700976
28	MP0009745_abnormal_behavioral_response	1.65859286
29	MP0005646_abnormal_pituitary_gland	1.65256059
30	MP0008875_abnormal_xenobiotic_pharmacok	1.62502146
31	MP0003787_abnormal_imprinting	1.61142738
32	MP0000427_abnormal_hair_cycle	1.57647540
33	MP0000631_abnormal_neuroendocrine_gland	1.57626860
34	MP0003880_abnormal_central_pattern	1.54922680
35	MP0001986_abnormal_taste_sensitivity	1.54671333
36	MP0002735_abnormal_chemical_nociception	1.50985363
37	MP0004133_heterotaxia	1.49165533
38	MP0000372_irregular_coat_pigmentation	1.46924358
39	MP0002272_abnormal_nervous_system	1.46831236
40	MP0002277_abnormal_respiratory_mucosa	1.45246798
41	MP0005075_abnormal_melanosome_morpholog	1.45080808
42	MP0005084_abnormal_gallbladder_morpholo	1.38414406
43	MP0003011_delayed_dark_adaptation	1.34762673
44	MP0002095_abnormal_skin_pigmentation	1.33044483
45	MP0005167_abnormal_blood-brain_barrier	1.31943892
46	MP0003718_maternal_effect	1.29481220
47	MP0006276_abnormal_autonomic_nervous	1.27668370
48	MP0009379_abnormal_foot_pigmentation	1.27190625
49	MP0001486_abnormal_startle_reflex	1.24904460
50	MP0001501_abnormal_sleep_pattern	1.22847984
51	MP0001984_abnormal_olfaction	1.21160140
52	MP0005389_reproductive_system_phenotype	1.20606727
53	MP0008995_early_reproductive_senescence	1.20098411
54	MP0001529_abnormal_vocalization	1.16752745
55	MP0001293_anophthalmia	1.15507786
56	MP0003890_abnormal_embryonic-extraembry	1.14472040
57	MP0004742_abnormal_vestibular_system	1.14250304
58	MP0002163_abnormal_gland_morphology	1.13494655
59	MP0002160_abnormal_reproductive_system	1.12943010
60	MP0002733_abnormal_thermal_nociception	1.12042250
61	MP0000383_abnormal_hair_follicle	1.10448951
62	MP0001919_abnormal_reproductive_system	1.09146578
63	MP0002064_seizures	1.08438146
64	MP0002928_abnormal_bile_duct	1.07112454
65	MP0002557_abnormal_social/conspecific_i	1.06623058
66	MP0002234_abnormal_pharynx_morphology	1.05528607
67	MP0002572_abnormal_emotion/affect_behav	1.05476602
68	MP0005195_abnormal_posterior_eye	1.05050299
69	MP0001970_abnormal_pain_threshold	1.04923989
70	MP0005379_endocrine/exocrine_gland_phen	1.00354031
71	MP0002210_abnormal_sex_determination	0.96985599
72	MP0002067_abnormal_sensory_capabilities	0.96036283
73	MP0001929_abnormal_gametogenesis	0.95515639
74	MP0002751_abnormal_autonomic_nervous	0.95289264
75	MP0001905_abnormal_dopamine_level	0.95050369
76	MP0005377_hearing/vestibular/ear_phenot	0.94595654
77	MP0003878_abnormal_ear_physiology	0.94595654
78	MP0010094_abnormal_chromosome_stability	0.93139918
79	MP0003119_abnormal_digestive_system	0.91443313
80	MP0003698_abnormal_male_reproductive	0.91095097
81	MP0005386_behavior/neurological_phenoty	0.88459679
82	MP0004924_abnormal_behavior	0.88459679
83	MP0000015_abnormal_ear_pigmentation	0.87682546
84	MP0002734_abnormal_mechanical_nocicepti	0.87476910
85	MP0001188_hyperpigmentation	0.85355543
86	MP0010386_abnormal_urinary_bladder	0.83545078
87	MP0005391_vision/eye_phenotype	0.83126195
88	MP0005410_abnormal_fertilization	0.82941285
89	MP0000230_abnormal_systemic_arterial	0.82700982
90	MP0004215_abnormal_myocardial_fiber	0.82580536
91	MP0001324_abnormal_eye_pigmentation	0.82273967
92	MP0000026_abnormal_inner_ear	0.81021416
93	MP0000647_abnormal_sebaceous_gland	0.80422759
94	MP0000653_abnormal_sex_gland	0.79854472
95	MP0002752_abnormal_somatic_nervous	0.78889406
96	MP0001145_abnormal_male_reproductive	0.78639058
97	MP0000778_abnormal_nervous_system	0.77888785
98	MP0003937_abnormal_limbs/digits/tail_de	0.75952476
99	MP0002063_abnormal_learning/memory/cond	0.74980727
100	MP0002184_abnormal_innervation	0.74153874

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.39316195
2	Congenital stationary night blindness (HP:0007642)	3.93623799
3	Abnormality of midbrain morphology (HP:0002418)	3.90740454
4	Molar tooth sign on MRI (HP:0002419)	3.90740454
5	Pancreatic fibrosis (HP:0100732)	3.83463634
6	True hermaphroditism (HP:0010459)	3.68637789
7	Nephronophthisis (HP:0000090)	3.56487871
8	Birth length less than 3rd percentile (HP:0003561)	3.19476677
9	Abnormality of the renal cortex (HP:0011035)	3.16192485
10	Type II lissencephaly (HP:0007260)	3.15358468
11	Abnormality of the renal medulla (HP:0100957)	3.08129537
12	Hyperventilation (HP:0002883)	2.95376960
13	Attenuation of retinal blood vessels (HP:0007843)	2.74452322
14	Medial flaring of the eyebrow (HP:0010747)	2.70887593
15	Congenital, generalized hypertrichosis (HP:0004540)	2.66589771
16	Pendular nystagmus (HP:0012043)	2.65610095
17	Tubular atrophy (HP:0000092)	2.64479438
18	Abnormality of alanine metabolism (HP:0010916)	2.59622859
19	Hyperalaninemia (HP:0003348)	2.59622859
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.59622859
21	Large for gestational age (HP:0001520)	2.57576911
22	Abolished electroretinogram (ERG) (HP:0000550)	2.53838834
23	Absent/shortened dynein arms (HP:0200106)	2.52582549
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.52582549
25	Cystic liver disease (HP:0006706)	2.51878942
26	Sclerocornea (HP:0000647)	2.42780275
27	Patellar aplasia (HP:0006443)	2.37922092
28	Inability to walk (HP:0002540)	2.37876416
29	Mitochondrial inheritance (HP:0001427)	2.33228226
30	Chronic hepatic failure (HP:0100626)	2.32260442
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.30607825
32	Polydipsia (HP:0001959)	2.28393509
33	Abnormal drinking behavior (HP:0030082)	2.28393509
34	Aplasia/Hypoplasia of the patella (HP:0006498)	2.28289344
35	Increased CSF lactate (HP:0002490)	2.27003375
36	Acute necrotizing encephalopathy (HP:0006965)	2.25865029
37	Abnormal respiratory epithelium morphology (HP:0012253)	2.20687782
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.20687782
39	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.18648158
40	Lissencephaly (HP:0001339)	2.17432639
41	Optic nerve hypoplasia (HP:0000609)	2.16548018
42	Renal cortical cysts (HP:0000803)	2.16064147
43	Furrowed tongue (HP:0000221)	2.13195864
44	Anencephaly (HP:0002323)	2.12256507
45	Abnormality of the pons (HP:0007361)	2.10066116
46	Cerebellar dysplasia (HP:0007033)	2.07721464
47	Gait imbalance (HP:0002141)	2.07152342
48	Abnormal ciliary motility (HP:0012262)	2.05466149
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.05168774
50	Congenital primary aphakia (HP:0007707)	2.03014312
51	Polyuria (HP:0000103)	2.02863117
52	Acute encephalopathy (HP:0006846)	2.02533650
53	Progressive macrocephaly (HP:0004481)	2.02462485
54	Increased corneal curvature (HP:0100692)	1.99530276
55	Keratoconus (HP:0000563)	1.99530276
56	Progressive inability to walk (HP:0002505)	1.99022369
57	Optic disc pallor (HP:0000543)	1.97336155
58	Hepatocellular necrosis (HP:0001404)	1.95859333
59	Male pseudohermaphroditism (HP:0000037)	1.94786683
60	Colon cancer (HP:0003003)	1.94467372
61	Septo-optic dysplasia (HP:0100842)	1.94448588
62	Hypoplasia of the pons (HP:0012110)	1.93852916
63	Stomach cancer (HP:0012126)	1.92975149
64	Congenital hepatic fibrosis (HP:0002612)	1.92407079
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92317907
66	Chorioretinal atrophy (HP:0000533)	1.92282112
67	Decreased central vision (HP:0007663)	1.91804292
68	Abnormality of the renal collecting system (HP:0004742)	1.90281906
69	Lipid accumulation in hepatocytes (HP:0006561)	1.88363261
70	Broad-based gait (HP:0002136)	1.88298843
71	Abnormality of the ileum (HP:0001549)	1.88111513
72	Meckel diverticulum (HP:0002245)	1.87507883
73	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87229213
74	Fair hair (HP:0002286)	1.87160175
75	Increased hepatocellular lipid droplets (HP:0006565)	1.86665198
76	Protruding tongue (HP:0010808)	1.86497984
77	Abnormal mitochondria in muscle tissue (HP:0008316)	1.86490351
78	Duplicated collecting system (HP:0000081)	1.86466288
79	Hepatic necrosis (HP:0002605)	1.85142346
80	Absent thumb (HP:0009777)	1.85040123
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85030409
82	Concave nail (HP:0001598)	1.84593127
83	Abnormality of the labia minora (HP:0012880)	1.84475697
84	3-Methylglutaconic aciduria (HP:0003535)	1.83832314
85	Gaze-evoked nystagmus (HP:0000640)	1.83606769
86	Abnormal number of erythroid precursors (HP:0012131)	1.83508946
87	Nephrogenic diabetes insipidus (HP:0009806)	1.83353205
88	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83293856
89	Methylmalonic acidemia (HP:0002912)	1.83284330
90	Bilateral microphthalmos (HP:0007633)	1.80565006
91	Bile duct proliferation (HP:0001408)	1.78357326
92	Abnormal biliary tract physiology (HP:0012439)	1.78357326
93	Hypothermia (HP:0002045)	1.77794199
94	Genital tract atresia (HP:0001827)	1.73958799
95	Retinal dysplasia (HP:0007973)	1.73136239
96	Bony spicule pigmentary retinopathy (HP:0007737)	1.72515341
97	Intestinal atresia (HP:0011100)	1.71465398
98	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.71355754
99	Hemiparesis (HP:0001269)	1.70509827
100	Anophthalmia (HP:0000528)	1.68956716

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.83135201
2	BMPR1B	3.95364480
3	ACVR1B	3.31224828
4	ZAK	3.26783663
5	ADRBK2	3.09638246
6	TLK1	2.63034878
7	WNK3	2.55118616
8	GRK1	2.51984863
9	TAOK3	2.33147711
10	WNK4	2.25175766
11	MAP4K2	2.15571911
12	NUAK1	2.09515660
13	CASK	1.99699561
14	INSRR	1.90598320
15	PNCK	1.79818870
16	MKNK2	1.71115206
17	PINK1	1.68382042
18	TGFBR1	1.61504061
19	MAPK13	1.57826160
20	TXK	1.55010373
21	DAPK2	1.54862168
22	STK39	1.33084428
23	OXSR1	1.30303724
24	VRK1	1.29093292
25	TAF1	1.27654372
26	BRSK2	1.26241812
27	WEE1	1.24118000
28	ADRBK1	1.21227112
29	MAP3K4	1.20324252
30	TNIK	1.17684761
31	VRK2	1.13916787
32	TRIM28	1.12914663
33	NME1	1.11551943
34	DYRK2	1.11064625
35	NEK2	1.10352165
36	BCKDK	1.05204812
37	PAK3	1.00957970
38	CAMKK2	0.97898232
39	MAPK15	0.95760399
40	TSSK6	0.95253311
41	MKNK1	0.91352752
42	MST4	0.89132182
43	PLK3	0.88034113
44	PRKCG	0.84002611
45	PLK4	0.78251353
46	PRKCE	0.75072769
47	TIE1	0.75068786
48	FGFR2	0.75044326
49	STK38L	0.70687347
50	RPS6KA5	0.69695131
51	TEC	0.69597016
52	NEK1	0.68192163
53	CDC7	0.67398351
54	AKT3	0.66526898
55	PTK2B	0.63730748
56	CSNK1G1	0.62806324
57	PHKG1	0.62674972
58	PHKG2	0.62674972
59	NTRK3	0.61574547
60	PRKCI	0.61422111
61	NTRK2	0.60560891
62	CHEK2	0.59836124
63	KIT	0.59650407
64	CSNK1G2	0.59116342
65	EIF2AK3	0.58548453
66	PLK2	0.57265076
67	MAP2K7	0.56923296
68	ATR	0.56119004
69	MAP2K6	0.55662449
70	MAPKAPK3	0.54969983
71	PLK1	0.53594713
72	IKBKB	0.52662377
73	NLK	0.51779868
74	PIK3CA	0.47324723
75	PKN1	0.47262054
76	CSNK1G3	0.47216009
77	MARK1	0.46929758
78	CAMK2A	0.45031053
79	PRKCQ	0.44257593
80	SRPK1	0.42439668
81	MAPKAPK5	0.42343202
82	CHUK	0.40875486
83	CAMK1	0.38926439
84	ITK	0.38824529
85	MAP2K1	0.37667256
86	IRAK1	0.37235947
87	PRKACA	0.36925725
88	CDK3	0.36566887
89	MAP2K2	0.36562145
90	MUSK	0.35838582
91	MARK3	0.35539594
92	STK3	0.35376542
93	BUB1	0.34552426
94	CSNK1A1	0.34485532
95	CAMKK1	0.32994916
96	ATM	0.32702337
97	PASK	0.32469038
98	EPHA3	0.32186429
99	EPHA4	0.30313015
100	CSNK1A1L	0.29987976

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.71194086
2	Phototransduction_Homo sapiens_hsa04744	2.63180148
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.47811551
4	Homologous recombination_Homo sapiens_hsa03440	2.41112817
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34455898
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.29513148
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.28180161
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.23182968
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.21405044
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.18318942
11	Parkinsons disease_Homo sapiens_hsa05012	2.08591070
12	Butanoate metabolism_Homo sapiens_hsa00650	2.06789609
13	RNA polymerase_Homo sapiens_hsa03020	2.06373351
14	Protein export_Homo sapiens_hsa03060	2.05263138
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03894268
16	Basal transcription factors_Homo sapiens_hsa03022	2.02843143
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.97494374
18	Nicotine addiction_Homo sapiens_hsa05033	1.89577347
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89538292
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.83892438
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69406238
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65653623
23	One carbon pool by folate_Homo sapiens_hsa00670	1.65152706
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.61540297
25	Ribosome_Homo sapiens_hsa03010	1.58424237
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.53185273
27	Huntingtons disease_Homo sapiens_hsa05016	1.49993195
28	RNA degradation_Homo sapiens_hsa03018	1.43084501
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34768382
30	Caffeine metabolism_Homo sapiens_hsa00232	1.32392861
31	Alzheimers disease_Homo sapiens_hsa05010	1.31146564
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.28320061
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25573879
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25198061
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16548063
36	Propanoate metabolism_Homo sapiens_hsa00640	1.16049992
37	Taste transduction_Homo sapiens_hsa04742	1.15681328
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14102691
39	Olfactory transduction_Homo sapiens_hsa04740	1.13403514
40	Peroxisome_Homo sapiens_hsa04146	1.11993657
41	Non-homologous end-joining_Homo sapiens_hsa03450	1.06722390
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03628110
43	Morphine addiction_Homo sapiens_hsa05032	1.02432835
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00238508
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.98723105
46	Proteasome_Homo sapiens_hsa03050	0.98562632
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97966535
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97407981
49	Sulfur metabolism_Homo sapiens_hsa00920	0.96658372
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96186198
51	ABC transporters_Homo sapiens_hsa02010	0.92793932
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92112022
53	Mismatch repair_Homo sapiens_hsa03430	0.91711077
54	Insulin secretion_Homo sapiens_hsa04911	0.88948358
55	Asthma_Homo sapiens_hsa05310	0.87896549
56	Serotonergic synapse_Homo sapiens_hsa04726	0.86831383
57	Retinol metabolism_Homo sapiens_hsa00830	0.85884662
58	Purine metabolism_Homo sapiens_hsa00230	0.85333838
59	Primary immunodeficiency_Homo sapiens_hsa05340	0.85061341
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83132404
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79606054
62	GABAergic synapse_Homo sapiens_hsa04727	0.79364988
63	Sulfur relay system_Homo sapiens_hsa04122	0.77837927
64	Regulation of autophagy_Homo sapiens_hsa04140	0.74036346
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70131282
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68755982
67	Circadian entrainment_Homo sapiens_hsa04713	0.68100208
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67183060
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66821972
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66278827
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65994844
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65285248
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.64838154
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64329570
75	Metabolic pathways_Homo sapiens_hsa01100	0.64216651
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61166635
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61157197
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60451361
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60144973
80	Histidine metabolism_Homo sapiens_hsa00340	0.57967058
81	Base excision repair_Homo sapiens_hsa03410	0.57504431
82	RNA transport_Homo sapiens_hsa03013	0.55799996
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55514422
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.52961388
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51082480
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.50781707
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46911620
88	Salivary secretion_Homo sapiens_hsa04970	0.45529653
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.45467984
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.44103163
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.42420450
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.42384693
93	DNA replication_Homo sapiens_hsa03030	0.39413599
94	Spliceosome_Homo sapiens_hsa03040	0.39085512
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37684108
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33893977
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.33842377
98	Cocaine addiction_Homo sapiens_hsa05030	0.33481722
99	Mineral absorption_Homo sapiens_hsa04978	0.32517017
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31600406

ZNF726

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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