ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of megakaryocyte differentiation (GO:0045654)	7.13248855
2	preassembly of GPI anchor in ER membrane (GO:0016254)	6.77377290
3	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	6.02865499
4	mannosylation (GO:0097502)	5.94621662
5	behavioral response to ethanol (GO:0048149)	5.60835436
6	righting reflex (GO:0060013)	5.52381545
7	adult feeding behavior (GO:0008343)	5.49348723
8	limb bud formation (GO:0060174)	5.36926843
9	NIK/NF-kappaB signaling (GO:0038061)	5.30472142
10	regulation of RIG-I signaling pathway (GO:0039535)	5.25726407
11	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.16874844
12	neural tube formation (GO:0001841)	5.13511097
13	regulation of protein polyubiquitination (GO:1902914)	4.95595252
14	GPI anchor biosynthetic process (GO:0006506)	4.77532776
15	GPI anchor metabolic process (GO:0006505)	4.74174061
16	response to pheromone (GO:0019236)	4.65209114
17	C-terminal protein amino acid modification (GO:0018410)	4.62121234
18	C-terminal protein lipidation (GO:0006501)	4.42815178
19	somite development (GO:0061053)	4.39237884
20	post-embryonic morphogenesis (GO:0009886)	4.31189030
21	lung morphogenesis (GO:0060425)	4.20494982
22	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.17636995
23	cornea development in camera-type eye (GO:0061303)	4.15424417
24	estrogen biosynthetic process (GO:0006703)	4.12820133
25	cell morphogenesis involved in neuron differentiation (GO:0048667)	4.01865791
26	ribosomal small subunit assembly (GO:0000028)	4.00388842
27	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.99584847
28	negative regulation of necroptotic process (GO:0060546)	3.96547745
29	tryptophan catabolic process (GO:0006569)	3.90370597
30	indole-containing compound catabolic process (GO:0042436)	3.90370597
31	indolalkylamine catabolic process (GO:0046218)	3.90370597
32	glial cell proliferation (GO:0014009)	3.86206752
33	necroptotic process (GO:0070266)	3.82440611
34	protein localization to cilium (GO:0061512)	3.80741553
35	L-fucose catabolic process (GO:0042355)	3.71672908
36	fucose catabolic process (GO:0019317)	3.71672908
37	L-fucose metabolic process (GO:0042354)	3.71672908
38	kynurenine metabolic process (GO:0070189)	3.67460536
39	DNA damage response, detection of DNA damage (GO:0042769)	3.58418761
40	regulation of hippo signaling (GO:0035330)	3.53528609
41	mitochondrial DNA replication (GO:0006264)	3.50015472
42	platelet dense granule organization (GO:0060155)	3.48579901
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.42969127
44	regulation of megakaryocyte differentiation (GO:0045652)	3.40573825
45	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.33005766
46	embryonic digestive tract morphogenesis (GO:0048557)	3.29356792
47	chaperone-mediated protein transport (GO:0072321)	3.29202688
48	reflex (GO:0060004)	3.29047347
49	regulation of posttranscriptional gene silencing (GO:0060147)	3.19554503
50	regulation of gene silencing by miRNA (GO:0060964)	3.19554503
51	regulation of gene silencing by RNA (GO:0060966)	3.19554503
52	negative regulation of necrotic cell death (GO:0060547)	3.16615243
53	hair cell differentiation (GO:0035315)	3.15746197
54	glycolipid biosynthetic process (GO:0009247)	3.12988880
55	short-chain fatty acid metabolic process (GO:0046459)	3.08347350
56	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.08261870
57	translational termination (GO:0006415)	3.02686059
58	viral transcription (GO:0019083)	2.98080845
59	N-acetylglucosamine metabolic process (GO:0006044)	2.94184214
60	amine catabolic process (GO:0009310)	2.93326254
61	cellular biogenic amine catabolic process (GO:0042402)	2.93326254
62	G-protein coupled receptor internalization (GO:0002031)	2.92744122
63	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.92144503
64	negative regulation of activin receptor signaling pathway (GO:0032926)	2.91600874
65	spinal cord development (GO:0021510)	2.87426641
66	rhodopsin mediated signaling pathway (GO:0016056)	2.85031705
67	behavioral response to nicotine (GO:0035095)	2.82551072
68	otic vesicle formation (GO:0030916)	2.81139725
69	tryptophan metabolic process (GO:0006568)	2.79909611
70	thalamus development (GO:0021794)	2.78919113
71	protein targeting to vacuole (GO:0006623)	2.78386418
72	protein targeting to lysosome (GO:0006622)	2.78386418
73	establishment of protein localization to vacuole (GO:0072666)	2.78386418
74	meiotic chromosome segregation (GO:0045132)	2.77354853
75	positive regulation of gastrulation (GO:2000543)	2.76855399
76	protein targeting to ER (GO:0045047)	2.74812919
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.72618742
78	protein localization to vacuole (GO:0072665)	2.72580676
79	protein localization to lysosome (GO:0061462)	2.72580676
80	cotranslational protein targeting to membrane (GO:0006613)	2.72398880
81	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.69687023
82	regulation of hematopoietic progenitor cell differentiation (GO:1901532)	2.69314901
83	embryonic epithelial tube formation (GO:0001838)	2.68313395
84	protein complex biogenesis (GO:0070271)	2.67408059
85	phasic smooth muscle contraction (GO:0014821)	2.67102118
86	somite rostral/caudal axis specification (GO:0032525)	2.66418969
87	translational elongation (GO:0006414)	2.65043760
88	indolalkylamine metabolic process (GO:0006586)	2.61171072
89	female gonad development (GO:0008585)	2.60884528
90	synapsis (GO:0007129)	2.59965381
91	epithelial cilium movement (GO:0003351)	2.58842577
92	aromatic amino acid family catabolic process (GO:0009074)	2.57933885
93	negative regulation of fibroblast apoptotic process (GO:2000270)	2.57713975
94	ATP synthesis coupled proton transport (GO:0015986)	2.56232150
95	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.56232150
96	neuron fate determination (GO:0048664)	2.55368030
97	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.55138502
98	cardiac ventricle formation (GO:0003211)	2.54795039
99	protein localization to endoplasmic reticulum (GO:0070972)	2.53797320
100	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.53012797

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78954651
2	VDR_22108803_ChIP-Seq_LS180_Human	3.07794363
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.83737249
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.80120448
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.58775148
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54091297
7	EWS_26573619_Chip-Seq_HEK293_Human	2.27803764
8	RNF2_27304074_Chip-Seq_NSC_Mouse	2.19640470
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.18361158
10	P300_19829295_ChIP-Seq_ESCs_Human	2.14563822
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11512624
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04333025
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.97963453
14	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.95710664
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.94987640
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.93614697
17	FUS_26573619_Chip-Seq_HEK293_Human	1.93013900
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92648079
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90081432
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87915074
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.84086123
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.80128786
23	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.74520373
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74464640
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.73841094
26	SOX2_19829295_ChIP-Seq_ESCs_Human	1.71956237
27	NANOG_19829295_ChIP-Seq_ESCs_Human	1.71956237
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.71060694
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.71060694
30	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.63031383
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.62154231
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.59618156
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.57422337
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56254948
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55034400
36	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.53492052
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52736974
38	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.52302430
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.51668954
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51095337
41	AR_20517297_ChIP-Seq_VCAP_Human	1.49550759
42	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48396985
43	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.48064960
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.46235767
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46235767
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40254007
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40044434
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.39222874
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36406492
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34675645
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.34350030
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32638588
53	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.30766568
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.30077921
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30058733
56	AR_25329375_ChIP-Seq_VCAP_Human	1.29635598
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28726487
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28457133
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27383604
60	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.23122475
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22312477
62	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.22195702
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21528089
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20627417
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20450944
66	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.20267635
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.18901824
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18584504
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17056372
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17026060
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15193448
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.12986080
73	HTT_18923047_ChIP-ChIP_STHdh_Human	1.11830308
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10630604
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.09125146
76	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08881465
77	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.07349379
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04842058
79	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04380152
80	RXR_22108803_ChIP-Seq_LS180_Human	1.02942659
81	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.02528994
82	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.02528994
83	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.01520338
84	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00785207
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00154215
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00086141
87	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.99914653
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.99885819
89	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99644625
90	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.99291971
91	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98933471
92	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98046407
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97790970
94	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.97452304
95	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.97228045
96	SMAD4_21799915_ChIP-Seq_A2780_Human	0.96981523
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96521207
98	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.95114128
99	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95085422
100	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94385734

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.03954840
2	MP0006072_abnormal_retinal_apoptosis	3.60609129
3	MP0009379_abnormal_foot_pigmentation	3.39618033
4	MP0003880_abnormal_central_pattern	2.92273324
5	MP0000372_irregular_coat_pigmentation	2.88285602
6	MP0002938_white_spotting	2.70682354
7	MP0003011_delayed_dark_adaptation	2.70038912
8	MP0003191_abnormal_cellular_cholesterol	2.63769874
9	MP0004142_abnormal_muscle_tone	2.63767167
10	MP0000631_abnormal_neuroendocrine_gland	2.61165376
11	MP0001293_anophthalmia	2.54395685
12	MP0005253_abnormal_eye_physiology	2.28805884
13	MP0002138_abnormal_hepatobiliary_system	2.18941446
14	MP0005551_abnormal_eye_electrophysiolog	2.03821054
15	MP0002009_preneoplasia	2.01198272
16	MP0004133_heterotaxia	1.98311683
17	MP0003195_calcinosis	1.96768251
18	MP0008995_early_reproductive_senescence	1.94687646
19	MP0008057_abnormal_DNA_replication	1.88852020
20	MP0005167_abnormal_blood-brain_barrier	1.79761450
21	MP0003718_maternal_effect	1.78761494
22	MP0005645_abnormal_hypothalamus_physiol	1.76923409
23	MP0010030_abnormal_orbit_morphology	1.74852713
24	MP0006276_abnormal_autonomic_nervous	1.63878058
25	MP0005671_abnormal_response_to	1.63819301
26	MP0003567_abnormal_fetal_cardiomyocyte	1.62059808
27	MP0003136_yellow_coat_color	1.57282841
28	MP0002234_abnormal_pharynx_morphology	1.54149999
29	MP0002736_abnormal_nociception_after	1.53112592
30	MP0008877_abnormal_DNA_methylation	1.52767336
31	MP0005085_abnormal_gallbladder_physiolo	1.51427066
32	MP0005391_vision/eye_phenotype	1.51245471
33	MP0005670_abnormal_white_adipose	1.49847260
34	MP0003646_muscle_fatigue	1.48326819
35	MP0002837_dystrophic_cardiac_calcinosis	1.47435642
36	MP0004147_increased_porphyrin_level	1.43104204
37	MP0003638_abnormal_response/metabolism_	1.41995479
38	MP0004019_abnormal_vitamin_homeostasis	1.39637005
39	MP0002139_abnormal_hepatobiliary_system	1.39340260
40	MP0002876_abnormal_thyroid_physiology	1.35556669
41	MP0005075_abnormal_melanosome_morpholog	1.34444642
42	MP0001324_abnormal_eye_pigmentation	1.28754572
43	MP0005646_abnormal_pituitary_gland	1.24626296
44	MP0005377_hearing/vestibular/ear_phenot	1.24174455
45	MP0003878_abnormal_ear_physiology	1.24174455
46	MP0005257_abnormal_intraocular_pressure	1.23901388
47	MP0002163_abnormal_gland_morphology	1.22362389
48	MP0003137_abnormal_impulse_conducting	1.21621694
49	MP0001968_abnormal_touch/_nociception	1.20087958
50	MP0002751_abnormal_autonomic_nervous	1.19595607
51	MP0003119_abnormal_digestive_system	1.18847119
52	MP0009046_muscle_twitch	1.18583238
53	MP0002909_abnormal_adrenal_gland	1.18463202
54	MP0005084_abnormal_gallbladder_morpholo	1.17977056
55	MP0008775_abnormal_heart_ventricle	1.17510000
56	MP0003787_abnormal_imprinting	1.11721996
57	MP0005195_abnormal_posterior_eye	1.10635626
58	MP0004782_abnormal_surfactant_physiolog	1.10468821
59	MP0003890_abnormal_embryonic-extraembry	1.07389229
60	MP0001764_abnormal_homeostasis	1.05880127
61	MP0003252_abnormal_bile_duct	1.05857085
62	MP0004270_analgesia	1.04882911
63	MP0004885_abnormal_endolymph	1.04649253
64	MP0002272_abnormal_nervous_system	1.02761045
65	MP0000534_abnormal_ureter_morphology	1.02394243
66	MP0004510_myositis	1.00505972
67	MP0005379_endocrine/exocrine_gland_phen	0.97124342
68	MP0000049_abnormal_middle_ear	0.95770383
69	MP0000230_abnormal_systemic_arterial	0.94971208
70	MP0001501_abnormal_sleep_pattern	0.93025230
71	MP0001485_abnormal_pinna_reflex	0.92929088
72	MP0001944_abnormal_pancreas_morphology	0.91466722
73	MP0000639_abnormal_adrenal_gland	0.91432144
74	MP0002928_abnormal_bile_duct	0.91155773
75	MP0010368_abnormal_lymphatic_system	0.91128863
76	MP0000778_abnormal_nervous_system	0.89760888
77	MP0003937_abnormal_limbs/digits/tail_de	0.88614277
78	MP0005083_abnormal_biliary_tract	0.88555814
79	MP0002735_abnormal_chemical_nociception	0.88283783
80	MP0003385_abnormal_body_wall	0.86265964
81	MP0006036_abnormal_mitochondrial_physio	0.85662154
82	MP0008872_abnormal_physiological_respon	0.84687165
83	MP0004043_abnormal_pH_regulation	0.84524458
84	MP0003786_premature_aging	0.83354241
85	MP0002295_abnormal_pulmonary_circulatio	0.81250576
86	MP0002067_abnormal_sensory_capabilities	0.81115510
87	MP0000470_abnormal_stomach_morphology	0.77722286
88	MP0004085_abnormal_heartbeat	0.76151321
89	MP0009745_abnormal_behavioral_response	0.75577682
90	MP0005197_abnormal_uvea_morphology	0.73137443
91	MP0002697_abnormal_eye_size	0.72250282
92	MP0002092_abnormal_eye_morphology	0.71504834
93	MP0002734_abnormal_mechanical_nocicepti	0.71175235
94	MP0005410_abnormal_fertilization	0.70670188
95	MP0002233_abnormal_nose_morphology	0.70371560
96	MP0000653_abnormal_sex_gland	0.70155962
97	MP0001881_abnormal_mammary_gland	0.69709582
98	MP0000647_abnormal_sebaceous_gland	0.67199381
99	MP0001873_stomach_inflammation	0.66968032
100	MP0002184_abnormal_innervation	0.64047318

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.87186954
2	Thrombocytosis (HP:0001894)	4.35293446
3	Spontaneous abortion (HP:0005268)	4.27172487
4	Nephronophthisis (HP:0000090)	4.14711887
5	Delayed CNS myelination (HP:0002188)	3.84765323
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.67447369
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.67447369
8	Hyperglycinemia (HP:0002154)	3.59609193
9	Acute necrotizing encephalopathy (HP:0006965)	3.28432723
10	Abnormality of midbrain morphology (HP:0002418)	3.22792815
11	Molar tooth sign on MRI (HP:0002419)	3.22792815
12	True hermaphroditism (HP:0010459)	3.20289584
13	Abnormality of the renal medulla (HP:0100957)	3.17080926
14	Congenital, generalized hypertrichosis (HP:0004540)	3.15623772
15	Chronic sinusitis (HP:0011109)	3.10633510
16	Abnormal number of erythroid precursors (HP:0012131)	3.08462998
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.88777103
18	Hepatocellular necrosis (HP:0001404)	2.87689845
19	Limb hypertonia (HP:0002509)	2.85211230
20	Adrenal hypoplasia (HP:0000835)	2.84707764
21	Acute encephalopathy (HP:0006846)	2.82097216
22	11 pairs of ribs (HP:0000878)	2.81456015
23	Abnormality of cells of the erythroid lineage (HP:0012130)	2.80818874
24	Progressive macrocephaly (HP:0004481)	2.80291731
25	Pancreatic cysts (HP:0001737)	2.79549502
26	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.79317995
27	Limb dystonia (HP:0002451)	2.66371879
28	Mitochondrial inheritance (HP:0001427)	2.63118154
29	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	2.61969034
30	Vertebral hypoplasia (HP:0008417)	2.61969034
31	Prostate neoplasm (HP:0100787)	2.59604414
32	Nonprogressive disorder (HP:0003680)	2.57644432
33	Hepatic necrosis (HP:0002605)	2.57126701
34	Pancreatic fibrosis (HP:0100732)	2.53867763
35	Increased CSF lactate (HP:0002490)	2.51472550
36	Anterior segment dysgenesis (HP:0007700)	2.49471912
37	Abnormality of the renal cortex (HP:0011035)	2.49278017
38	Agammaglobulinemia (HP:0004432)	2.48443333
39	Supernumerary spleens (HP:0009799)	2.44706640
40	Congenital sensorineural hearing impairment (HP:0008527)	2.42529946
41	Proximal tubulopathy (HP:0000114)	2.40666610
42	Reticulocytopenia (HP:0001896)	2.38905270
43	Abolished electroretinogram (ERG) (HP:0000550)	2.34572176
44	Hypothermia (HP:0002045)	2.33967767
45	Cerebellar dysplasia (HP:0007033)	2.32767495
46	Chronic hepatic failure (HP:0100626)	2.32525319
47	Generalized aminoaciduria (HP:0002909)	2.30245334
48	Abnormal sex determination (HP:0012244)	2.29937399
49	Sex reversal (HP:0012245)	2.29937399
50	Hypoplastic pelvis (HP:0008839)	2.28699486
51	Septo-optic dysplasia (HP:0100842)	2.28068489
52	Cerebral edema (HP:0002181)	2.22738263
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.17906363
54	Hypokinesia (HP:0002375)	2.17004004
55	Parakeratosis (HP:0001036)	2.15329454
56	Tubulointerstitial nephritis (HP:0001970)	2.13751290
57	Scotoma (HP:0000575)	2.08694633
58	Abnormality of hair growth rate (HP:0011363)	2.08149857
59	Slow-growing hair (HP:0002217)	2.08149857
60	Broad-based gait (HP:0002136)	2.07862869
61	Muscular hypotonia of the trunk (HP:0008936)	2.05635437
62	Abnormality of macular pigmentation (HP:0008002)	2.03204083
63	Leukodystrophy (HP:0002415)	2.02042256
64	Colon cancer (HP:0003003)	2.00098073
65	Global brain atrophy (HP:0002283)	1.99497366
66	Progressive inability to walk (HP:0002505)	1.97793196
67	Renal cortical cysts (HP:0000803)	1.97526454
68	Pachygyria (HP:0001302)	1.93913426
69	Abnormality of the middle phalanges of the toes (HP:0010183)	1.93832324
70	Tubular atrophy (HP:0000092)	1.92492037
71	Large eyes (HP:0001090)	1.92213278
72	Absent eyebrow (HP:0002223)	1.91103155
73	Abnormality of the pupil (HP:0000615)	1.90757277
74	Congenital hepatic fibrosis (HP:0002612)	1.90252060
75	Cortical visual impairment (HP:0100704)	1.89281436
76	Generalized myoclonic seizures (HP:0002123)	1.88386632
77	Inability to walk (HP:0002540)	1.87057327
78	Prominent supraorbital ridges (HP:0000336)	1.86819472
79	Medial flaring of the eyebrow (HP:0010747)	1.86486569
80	Prolonged partial thromboplastin time (HP:0003645)	1.84838130
81	Muscle fibrillation (HP:0010546)	1.83904532
82	Male pseudohermaphroditism (HP:0000037)	1.81714852
83	Palpitations (HP:0001962)	1.80796467
84	Abnormality of the prostate (HP:0008775)	1.79745239
85	Optic disc pallor (HP:0000543)	1.78974569
86	Stage 5 chronic kidney disease (HP:0003774)	1.78792223
87	Recurrent bronchitis (HP:0002837)	1.78167069
88	Progressive external ophthalmoplegia (HP:0000590)	1.78134435
89	Duplication of thumb phalanx (HP:0009942)	1.76009516
90	Abnormal spermatogenesis (HP:0008669)	1.75992748
91	Tongue fasciculations (HP:0001308)	1.75976174
92	Lissencephaly (HP:0001339)	1.75718354
93	Hypoplasia of the pons (HP:0012110)	1.73889643
94	Abnormal ventriculo-arterial connection (HP:0011563)	1.73541768
95	Transposition of the great arteries (HP:0001669)	1.73541768
96	Abnormal connection of the cardiac segments (HP:0011545)	1.73541768
97	Optic nerve hypoplasia (HP:0000609)	1.73407691
98	Facial diplegia (HP:0001349)	1.71762630
99	Oligomenorrhea (HP:0000876)	1.71132323
100	Type 2 muscle fiber atrophy (HP:0003554)	1.70515969

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	8.37579260
2	GRK1	5.42523242
3	TIE1	3.65960348
4	MAP4K2	3.30580281
5	WNK3	2.94038850
6	MST4	2.72022617
7	SIK3	2.62761449
8	BCKDK	2.36676229
9	ZAK	2.35832124
10	TRIM28	2.35627385
11	MAP3K12	2.06608743
12	FRK	1.97355915
13	EPHA4	1.89614477
14	CASK	1.88487110
15	ACVR1B	1.67850511
16	BMPR1B	1.61788531
17	MAPKAPK3	1.39894847
18	ERBB3	1.26517062
19	TEC	1.23695423
20	BCR	1.21053203
21	STK16	1.12990353
22	WNK4	1.12963511
23	MAP3K13	1.04587169
24	TAF1	1.04041567
25	ADRBK2	0.99892127
26	OXSR1	0.98109625
27	UHMK1	0.97116140
28	YES1	0.96870667
29	STK39	0.95525723
30	PINK1	0.91426427
31	MKNK2	0.87060876
32	DYRK2	0.80634850
33	VRK1	0.80073699
34	TGFBR1	0.79282377
35	ARAF	0.77747745
36	CSNK1G2	0.74565052
37	EPHA2	0.74013096
38	MKNK1	0.73916119
39	TLK1	0.73141300
40	NTRK3	0.70779553
41	KIT	0.65066797
42	DYRK1B	0.64763161
43	CSNK1G3	0.64706683
44	CDK6	0.62552311
45	PBK	0.60256262
46	INSRR	0.59159622
47	DAPK2	0.58726273
48	MAP3K9	0.57769385
49	PRKCQ	0.57287117
50	MAP3K4	0.56516625
51	CDK19	0.56362566
52	CCNB1	0.54631594
53	LRRK2	0.53390760
54	CAMK2D	0.52436528
55	ITK	0.51957098
56	CSNK1G1	0.49132048
57	TXK	0.48359968
58	CSNK2A1	0.48333470
59	DYRK3	0.46149222
60	CAMK2B	0.45294973
61	CAMK2G	0.43467273
62	CSNK1A1L	0.43422642
63	MAP2K7	0.42686373
64	PRKCE	0.42166906
65	PLK3	0.41590812
66	PRKCG	0.41551809
67	PIK3CG	0.40714859
68	PLK2	0.40525102
69	PRKACA	0.39444252
70	NUAK1	0.39038482
71	GRK7	0.38508568
72	MYLK	0.37118053
73	PASK	0.37075463
74	CSNK2A2	0.36864752
75	DAPK1	0.36858594
76	ATR	0.36111937
77	PRKACG	0.34501924
78	OBSCN	0.33637832
79	BMPR2	0.33343153
80	CSNK1E	0.31899923
81	LYN	0.31742063
82	ADRBK1	0.30927831
83	VRK2	0.29921505
84	STK38L	0.29881593
85	RPS6KA5	0.29779570
86	MAP3K11	0.29236111
87	IKBKB	0.29178497
88	IRAK4	0.28222104
89	MATK	0.27996722
90	CAMK2A	0.27663350
91	KDR	0.27504026
92	IGF1R	0.26665587
93	SRPK1	0.25078918
94	STK3	0.23696169
95	PHKG1	0.23393263
96	PHKG2	0.23393263
97	PTK2B	0.23278575
98	RPS6KA6	0.22851857
99	PRKCA	0.22427303
100	PRKACB	0.21278686

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	5.07526994
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.34579671
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.24648599
4	Basal transcription factors_Homo sapiens_hsa03022	3.24524631
5	Phototransduction_Homo sapiens_hsa04744	3.12170661
6	Protein export_Homo sapiens_hsa03060	2.74478853
7	Ribosome_Homo sapiens_hsa03010	2.68707813
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.37661286
9	Parkinsons disease_Homo sapiens_hsa05012	2.31978442
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94326348
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89810630
12	Propanoate metabolism_Homo sapiens_hsa00640	1.82826796
13	Proteasome_Homo sapiens_hsa03050	1.77544773
14	Alzheimers disease_Homo sapiens_hsa05010	1.73454003
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72047446
16	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.62821667
17	Huntingtons disease_Homo sapiens_hsa05016	1.54647286
18	Taste transduction_Homo sapiens_hsa04742	1.51075006
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39334529
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.37044298
21	Sulfur metabolism_Homo sapiens_hsa00920	1.36300695
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29494729
23	Retinol metabolism_Homo sapiens_hsa00830	1.27820674
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.23898231
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22522448
26	Olfactory transduction_Homo sapiens_hsa04740	1.19012683
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.17826243
28	Butanoate metabolism_Homo sapiens_hsa00650	1.16561813
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16315117
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.15980524
31	Peroxisome_Homo sapiens_hsa04146	1.11795588
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.11086841
33	Asthma_Homo sapiens_hsa05310	1.10685622
34	RNA degradation_Homo sapiens_hsa03018	1.06433267
35	Folate biosynthesis_Homo sapiens_hsa00790	1.06311209
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06160184
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05398404
38	RNA polymerase_Homo sapiens_hsa03020	1.03457471
39	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.02514544
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.02309059
41	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.00766429
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98219408
43	Histidine metabolism_Homo sapiens_hsa00340	0.97369440
44	Type I diabetes mellitus_Homo sapiens_hsa04940	0.91476409
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.88477451
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88030312
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.87553939
48	Metabolic pathways_Homo sapiens_hsa01100	0.81531856
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81051785
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80893437
51	One carbon pool by folate_Homo sapiens_hsa00670	0.78538331
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77957051
53	Homologous recombination_Homo sapiens_hsa03440	0.75871370
54	Nicotine addiction_Homo sapiens_hsa05033	0.74469528
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72683700
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72382269
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.71591251
58	Allograft rejection_Homo sapiens_hsa05330	0.71401798
59	Sulfur relay system_Homo sapiens_hsa04122	0.67911143
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67356368
61	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65496327
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.62516431
63	Graft-versus-host disease_Homo sapiens_hsa05332	0.62423525
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60007192
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59159432
66	Spliceosome_Homo sapiens_hsa03040	0.58167180
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57874123
68	Fatty acid degradation_Homo sapiens_hsa00071	0.56632792
69	African trypanosomiasis_Homo sapiens_hsa05143	0.56580728
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56575171
71	Small cell lung cancer_Homo sapiens_hsa05222	0.54285566
72	Purine metabolism_Homo sapiens_hsa00230	0.53754624
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.53663631
74	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.53522914
75	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52718629
76	Salivary secretion_Homo sapiens_hsa04970	0.52456374
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52152163
78	Caffeine metabolism_Homo sapiens_hsa00232	0.52130312
79	Serotonergic synapse_Homo sapiens_hsa04726	0.52076614
80	Primary immunodeficiency_Homo sapiens_hsa05340	0.48786736
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.48005173
82	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.46510698
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43905444
84	Circadian entrainment_Homo sapiens_hsa04713	0.42809590
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42629495
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39843812
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.38475914
88	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38413980
89	Glutathione metabolism_Homo sapiens_hsa00480	0.38252874
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.38158013
91	Circadian rhythm_Homo sapiens_hsa04710	0.37303810
92	ABC transporters_Homo sapiens_hsa02010	0.34727131
93	Insulin secretion_Homo sapiens_hsa04911	0.34456560
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33486018
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33161817
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.33020994
97	Morphine addiction_Homo sapiens_hsa05032	0.31404035
98	Mismatch repair_Homo sapiens_hsa03430	0.30045901
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.28840975
100	Gastric acid secretion_Homo sapiens_hsa04971	0.28104577

ZNF72P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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