ZNF730

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.33381290
2CENP-A containing nucleosome assembly (GO:0034080)5.12091354
3kinetochore organization (GO:0051383)4.92299791
4kinetochore assembly (GO:0051382)4.80270914
5DNA double-strand break processing (GO:0000729)4.66172020
6histone exchange (GO:0043486)4.44432864
7DNA replication-independent nucleosome assembly (GO:0006336)4.16355849
8DNA replication-independent nucleosome organization (GO:0034724)4.16355849
9DNA replication checkpoint (GO:0000076)4.09863890
10replication fork processing (GO:0031297)3.84000209
11protein localization to kinetochore (GO:0034501)3.81606980
12metaphase plate congression (GO:0051310)3.76023969
13DNA ligation (GO:0006266)3.75875225
14DNA strand elongation involved in DNA replication (GO:0006271)3.75265146
15somatic diversification of immune receptors via somatic mutation (GO:0002566)3.71928327
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.71928327
17DNA replication-dependent nucleosome organization (GO:0034723)3.68990330
18DNA replication-dependent nucleosome assembly (GO:0006335)3.68990330
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.59178872
20mitotic metaphase plate congression (GO:0007080)3.57263477
21DNA strand elongation (GO:0022616)3.54308535
22negative regulation of DNA recombination (GO:0045910)3.50993759
23telomere maintenance via semi-conservative replication (GO:0032201)3.50057988
24regulation of centriole replication (GO:0046599)3.48824353
25establishment of integrated proviral latency (GO:0075713)3.48153367
26regulation of mitotic spindle checkpoint (GO:1903504)3.32768845
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32768845
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.31190725
29DNA damage response, detection of DNA damage (GO:0042769)3.27819158
30regulation of helicase activity (GO:0051095)3.24364582
31mitotic recombination (GO:0006312)3.23369046
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17845409
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.17845409
34regulation of translation, ncRNA-mediated (GO:0045974)3.17845409
35negative regulation of mitotic sister chromatid separation (GO:2000816)3.13077369
36negative regulation of sister chromatid segregation (GO:0033046)3.13077369
37negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13077369
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13077369
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13077369
40spindle checkpoint (GO:0031577)3.11928362
41telomere maintenance via recombination (GO:0000722)3.09595458
42ATP-dependent chromatin remodeling (GO:0043044)3.08319578
43DNA strand renaturation (GO:0000733)3.07548204
44mitotic spindle checkpoint (GO:0071174)3.07387482
45mitotic G2/M transition checkpoint (GO:0044818)3.07149722
46centriole replication (GO:0007099)3.06340912
47microtubule depolymerization (GO:0007019)3.06239986
48negative regulation of chromosome segregation (GO:0051985)3.05916351
49presynaptic membrane assembly (GO:0097105)3.04445269
50recombinational repair (GO:0000725)3.03503010
51DNA catabolic process, exonucleolytic (GO:0000738)3.01950840
52double-strand break repair via homologous recombination (GO:0000724)2.99569714
53regulation of DNA endoreduplication (GO:0032875)2.98656242
54nucleotide-excision repair, DNA gap filling (GO:0006297)2.97126164
55protein K6-linked ubiquitination (GO:0085020)2.95597221
56double-strand break repair via nonhomologous end joining (GO:0006303)2.95509161
57non-recombinational repair (GO:0000726)2.95509161
58protein localization to chromosome, centromeric region (GO:0071459)2.95495174
59sister chromatid segregation (GO:0000819)2.92411161
60mitotic sister chromatid segregation (GO:0000070)2.92362850
61synapsis (GO:0007129)2.92109254
62regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89421406
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89421406
64mitotic spindle assembly checkpoint (GO:0007094)2.89241833
65postreplication repair (GO:0006301)2.87964991
66spindle assembly checkpoint (GO:0071173)2.84368731
67mitotic sister chromatid cohesion (GO:0007064)2.83739853
68resolution of meiotic recombination intermediates (GO:0000712)2.82054415
69regulation of development, heterochronic (GO:0040034)2.81954109
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81584815
71purine nucleobase biosynthetic process (GO:0009113)2.79300825
72intraciliary transport (GO:0042073)2.78850664
73regulation of double-strand break repair via homologous recombination (GO:0010569)2.77671454
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75981842
75translesion synthesis (GO:0019985)2.75626288
76DNA unwinding involved in DNA replication (GO:0006268)2.75463687
77regulation of sister chromatid segregation (GO:0033045)2.75096779
78regulation of mitotic sister chromatid separation (GO:0010965)2.75096779
79regulation of mitotic sister chromatid segregation (GO:0033047)2.75096779
80regulation of timing of cell differentiation (GO:0048505)2.69650332
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.69375438
82DNA topological change (GO:0006265)2.69116925
83regulation of nuclear cell cycle DNA replication (GO:0033262)2.68840955
84DNA replication initiation (GO:0006270)2.68188020
85protein neddylation (GO:0045116)2.66529454
86regulation of centrosome cycle (GO:0046605)2.66337920
87chromatin assembly or disassembly (GO:0006333)2.66054976
88establishment of chromosome localization (GO:0051303)2.65707603
89histone mRNA metabolic process (GO:0008334)2.65497746
90negative regulation of mitosis (GO:0045839)2.63815327
91telomere maintenance via telomere lengthening (GO:0010833)2.63040093
92regulation of chromosome segregation (GO:0051983)2.60174082
93heterochromatin organization (GO:0070828)2.59850585
94negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.59579907
95proteasome assembly (GO:0043248)2.59158871
96pre-miRNA processing (GO:0031054)2.58182746
97establishment of viral latency (GO:0019043)2.55743328
98presynaptic membrane organization (GO:0097090)2.53827097
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53707326
100cullin deneddylation (GO:0010388)2.52729012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.01075472
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67391661
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13390194
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.98090227
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.83921075
6ZNF274_21170338_ChIP-Seq_K562_Hela2.79155662
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.77126806
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.61334116
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60651056
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58526999
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.58020622
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.52280938
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30407973
14FUS_26573619_Chip-Seq_HEK293_Human2.18384677
15IGF1R_20145208_ChIP-Seq_DFB_Human2.18174647
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17839131
17EWS_26573619_Chip-Seq_HEK293_Human2.17250267
18ELK1_19687146_ChIP-ChIP_HELA_Human2.13934282
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.13012457
20VDR_22108803_ChIP-Seq_LS180_Human2.03089214
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01281777
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97796061
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92126185
24TAF15_26573619_Chip-Seq_HEK293_Human1.91091380
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83588356
26GBX2_23144817_ChIP-Seq_PC3_Human1.81009338
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76792663
28P300_19829295_ChIP-Seq_ESCs_Human1.76720377
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.76630680
30AR_21909140_ChIP-Seq_LNCAP_Human1.75121573
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.70562465
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67760457
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66552118
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.64635291
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62549180
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.61699395
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.60142397
38MYC_18940864_ChIP-ChIP_HL60_Human1.59788183
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.54566734
40IRF1_19129219_ChIP-ChIP_H3396_Human1.52381222
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49329036
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48820318
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48322983
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44542301
45VDR_23849224_ChIP-Seq_CD4+_Human1.41649712
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36278681
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35625161
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34964504
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.33896030
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33380433
51FOXP3_21729870_ChIP-Seq_TREG_Human1.29497001
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28455792
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25959017
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25589713
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23851925
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21421617
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20014662
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19882414
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15456805
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14802459
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13444384
62TTF2_22483619_ChIP-Seq_HELA_Human1.12834284
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.10160127
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08232584
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.07068697
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06962611
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06962611
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06962611
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06106490
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06045303
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05856107
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05174746
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05174746
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04587895
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03401306
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02391524
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02291701
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00699727
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.00020648
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99273904
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99264143
82SOX9_26525672_Chip-Seq_HEART_Mouse0.98782271
83RNF2_27304074_Chip-Seq_NSC_Mouse0.98358792
84E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98352639
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.96971224
86SMAD4_21799915_ChIP-Seq_A2780_Human0.96472418
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.96262542
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95885532
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95772643
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95485448
91MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94967158
92TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93924326
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93325766
94TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92985310
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92875403
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92657602
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90700868
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90606040
99ER_23166858_ChIP-Seq_MCF-7_Human0.88501385
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88170860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.33450678
2MP0010094_abnormal_chromosome_stability3.30954151
3MP0003890_abnormal_embryonic-extraembry3.07204317
4MP0008057_abnormal_DNA_replication2.76166488
5MP0008058_abnormal_DNA_repair2.72638069
6MP0003880_abnormal_central_pattern2.61081114
7MP0008877_abnormal_DNA_methylation2.60724848
8MP0003693_abnormal_embryo_hatching2.57531106
9MP0010030_abnormal_orbit_morphology2.51874192
10MP0003136_yellow_coat_color2.36332543
11MP0004957_abnormal_blastocyst_morpholog2.26352111
12MP0001529_abnormal_vocalization2.22882220
13MP0001293_anophthalmia2.22517440
14MP0008789_abnormal_olfactory_epithelium2.07952010
15MP0003111_abnormal_nucleus_morphology2.05027320
16MP0002938_white_spotting2.02499980
17MP0008932_abnormal_embryonic_tissue1.94535039
18MP0003937_abnormal_limbs/digits/tail_de1.93930578
19MP0005394_taste/olfaction_phenotype1.91927517
20MP0005499_abnormal_olfactory_system1.91927517
21MP0000566_synostosis1.87880739
22MP0003077_abnormal_cell_cycle1.84806139
23MP0006072_abnormal_retinal_apoptosis1.83236430
24MP0003122_maternal_imprinting1.79806441
25MP0004133_heterotaxia1.79474104
26MP0003941_abnormal_skin_development1.77853331
27MP0003121_genomic_imprinting1.74514894
28MP0003567_abnormal_fetal_cardiomyocyte1.65430180
29MP0002736_abnormal_nociception_after1.64358458
30MP0002751_abnormal_autonomic_nervous1.64176972
31MP0009697_abnormal_copulation1.58800493
32MP0002233_abnormal_nose_morphology1.57792092
33MP0003119_abnormal_digestive_system1.54028000
34MP0000049_abnormal_middle_ear1.51534177
35MP0001286_abnormal_eye_development1.47932025
36MP0002653_abnormal_ependyma_morphology1.45781352
37MP0000778_abnormal_nervous_system1.44434403
38MP0003718_maternal_effect1.43825641
39MP0002102_abnormal_ear_morphology1.43791965
40MP0002697_abnormal_eye_size1.34853053
41MP0000631_abnormal_neuroendocrine_gland1.33169538
42MP0005253_abnormal_eye_physiology1.32011402
43MP0001984_abnormal_olfaction1.23569821
44MP0001177_atelectasis1.21329816
45MP0005248_abnormal_Harderian_gland1.21277711
46MP0003787_abnormal_imprinting1.20204928
47MP0000647_abnormal_sebaceous_gland1.19923412
48MP0002234_abnormal_pharynx_morphology1.18462101
49MP0006276_abnormal_autonomic_nervous1.17815803
50MP0002210_abnormal_sex_determination1.15029066
51MP0002084_abnormal_developmental_patter1.14824074
52MP0003861_abnormal_nervous_system1.14466023
53MP0002085_abnormal_embryonic_tissue1.10539501
54MP0008995_early_reproductive_senescence1.10538572
55MP0009672_abnormal_birth_weight1.10491351
56MP0003755_abnormal_palate_morphology1.08861410
57MP0005391_vision/eye_phenotype1.08346193
58MP0002111_abnormal_tail_morphology1.08344221
59MP0001188_hyperpigmentation1.07482960
60MP0008007_abnormal_cellular_replicative1.03576084
61MP0009703_decreased_birth_body1.03157304
62MP0001929_abnormal_gametogenesis1.02330364
63MP0001968_abnormal_touch/_nociception1.01934094
64MP0005551_abnormal_eye_electrophysiolog1.01462878
65MP0001485_abnormal_pinna_reflex1.01016313
66MP0003938_abnormal_ear_development0.99734230
67MP0001299_abnormal_eye_distance/0.99522143
68MP0001145_abnormal_male_reproductive0.97925264
69MP0003786_premature_aging0.96600287
70MP0004197_abnormal_fetal_growth/weight/0.96401804
71MP0000653_abnormal_sex_gland0.96055278
72MP0004147_increased_porphyrin_level0.94884626
73MP0005084_abnormal_gallbladder_morpholo0.93731749
74MP0001672_abnormal_embryogenesis/_devel0.93440547
75MP0005380_embryogenesis_phenotype0.93440547
76MP0001346_abnormal_lacrimal_gland0.92481407
77MP0003315_abnormal_perineum_morphology0.91917592
78MP0000537_abnormal_urethra_morphology0.91895110
79MP0001697_abnormal_embryo_size0.89642419
80MP0000428_abnormal_craniofacial_morphol0.86413034
81MP0003698_abnormal_male_reproductive0.85780985
82MP0002254_reproductive_system_inflammat0.84837737
83MP0005195_abnormal_posterior_eye0.83922980
84MP0002092_abnormal_eye_morphology0.82134512
85MP0000383_abnormal_hair_follicle0.81302239
86MP0002752_abnormal_somatic_nervous0.81278493
87MP0006035_abnormal_mitochondrial_morpho0.80743220
88MP0000427_abnormal_hair_cycle0.80740450
89MP0001486_abnormal_startle_reflex0.80505269
90MP0001119_abnormal_female_reproductive0.80163482
91MP0005187_abnormal_penis_morphology0.79419374
92MP0000579_abnormal_nail_morphology0.76482865
93MP0002160_abnormal_reproductive_system0.75549150
94MP0002557_abnormal_social/conspecific_i0.75494315
95MP0002638_abnormal_pupillary_reflex0.74466978
96MP0003984_embryonic_growth_retardation0.74356964
97MP0002088_abnormal_embryonic_growth/wei0.74353386
98MP0000026_abnormal_inner_ear0.74315885
99MP0004215_abnormal_myocardial_fiber0.73749639
100MP0002152_abnormal_brain_morphology0.73591071

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.71998749
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.55837759
3Abnormality of the labia minora (HP:0012880)3.47074890
4Meckel diverticulum (HP:0002245)3.41813170
5Abnormality of the ileum (HP:0001549)3.33870106
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.32175962
7Chromsome breakage (HP:0040012)3.28740051
8Intestinal atresia (HP:0011100)3.22466759
9Septo-optic dysplasia (HP:0100842)3.20906159
10Abnormality of chromosome stability (HP:0003220)3.03009696
11Abnormal lung lobation (HP:0002101)2.76767384
12Pancreatic cysts (HP:0001737)2.73312100
13True hermaphroditism (HP:0010459)2.62025512
14Pancreatic fibrosis (HP:0100732)2.60904424
15Cortical dysplasia (HP:0002539)2.57052207
16Triphalangeal thumb (HP:0001199)2.56178713
17Birth length less than 3rd percentile (HP:0003561)2.55963976
18Abnormality of midbrain morphology (HP:0002418)2.45755647
19Molar tooth sign on MRI (HP:0002419)2.45755647
20Abnormality of the duodenum (HP:0002246)2.45088868
21Absent radius (HP:0003974)2.44695899
22Abnormality of the preputium (HP:0100587)2.44211385
23Volvulus (HP:0002580)2.42219219
24Absent forearm bone (HP:0003953)2.40935137
25Aplasia involving forearm bones (HP:0009822)2.40935137
26Duodenal stenosis (HP:0100867)2.40593474
27Small intestinal stenosis (HP:0012848)2.40593474
28Absent septum pellucidum (HP:0001331)2.36917339
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36761324
30Ectopic kidney (HP:0000086)2.36442644
31Optic nerve hypoplasia (HP:0000609)2.34930480
32Nephronophthisis (HP:0000090)2.34150405
33Supernumerary spleens (HP:0009799)2.33360324
34Medulloblastoma (HP:0002885)2.32808951
35Oligodactyly (hands) (HP:0001180)2.28088545
36Gastrointestinal atresia (HP:0002589)2.18517041
37Abnormality of the septum pellucidum (HP:0007375)2.17946575
38Bifid tongue (HP:0010297)2.15709742
39Sloping forehead (HP:0000340)2.12502652
40Hyperglycinemia (HP:0002154)2.11476973
41Anophthalmia (HP:0000528)2.10222016
42Stenosis of the external auditory canal (HP:0000402)2.07716086
43Abnormality of the carotid arteries (HP:0005344)2.06897091
44Hypoplastic pelvis (HP:0008839)2.05083869
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.04626915
46Hemivertebrae (HP:0002937)2.03792153
47Reticulocytopenia (HP:0001896)2.02282533
48Aqueductal stenosis (HP:0002410)2.01330112
49Dandy-Walker malformation (HP:0001305)2.00712939
50Preaxial hand polydactyly (HP:0001177)2.00070222
51Esophageal atresia (HP:0002032)1.99996068
52Cerebellar dysplasia (HP:0007033)1.98538088
53Anencephaly (HP:0002323)1.97374580
54Hypoplastic female external genitalia (HP:0012815)1.97082984
55Genital tract atresia (HP:0001827)1.96974090
56Horseshoe kidney (HP:0000085)1.96876677
57Ependymoma (HP:0002888)1.95363038
58Rhabdomyosarcoma (HP:0002859)1.94929722
59Vaginal atresia (HP:0000148)1.94777240
60Labial hypoplasia (HP:0000066)1.94038408
61Medial flaring of the eyebrow (HP:0010747)1.92596655
62Oligodactyly (HP:0012165)1.92186531
63Patellar aplasia (HP:0006443)1.91084754
64Renal hypoplasia (HP:0000089)1.89857746
65Hepatoblastoma (HP:0002884)1.89181110
66Abnormality of the renal medulla (HP:0100957)1.87535139
67Glioma (HP:0009733)1.86306479
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.85868652
69Neoplasm of the oral cavity (HP:0100649)1.85087471
70Clubbing of toes (HP:0100760)1.84770427
71Nephroblastoma (Wilms tumor) (HP:0002667)1.84583784
72Pancreatic islet-cell hyperplasia (HP:0004510)1.84561409
73Postaxial hand polydactyly (HP:0001162)1.80847443
74Congenital primary aphakia (HP:0007707)1.79792708
75Embryonal renal neoplasm (HP:0011794)1.78966258
76Postaxial foot polydactyly (HP:0001830)1.76697918
77Sclerocornea (HP:0000647)1.76187234
78Gait imbalance (HP:0002141)1.75867866
79Bile duct proliferation (HP:0001408)1.75570887
80Abnormal biliary tract physiology (HP:0012439)1.75570887
81Bilateral microphthalmos (HP:0007633)1.75314025
82Pendular nystagmus (HP:0012043)1.75083944
83Short tibia (HP:0005736)1.74908160
84Hyperglycinuria (HP:0003108)1.74820416
85Rib fusion (HP:0000902)1.73268561
86Chronic hepatic failure (HP:0100626)1.71867109
87Aplasia/Hypoplasia of the patella (HP:0006498)1.70467962
88Retinal dysplasia (HP:0007973)1.69280769
89Increased hepatocellular lipid droplets (HP:0006565)1.68993211
90Holoprosencephaly (HP:0001360)1.67746407
91Acute encephalopathy (HP:0006846)1.66410715
92Growth hormone deficiency (HP:0000824)1.66279983
93Type II lissencephaly (HP:0007260)1.66176338
94Breast aplasia (HP:0100783)1.65941942
95Aplasia/Hypoplasia of the sternum (HP:0006714)1.65423545
96Carpal bone hypoplasia (HP:0001498)1.65324027
97Nephrogenic diabetes insipidus (HP:0009806)1.64645083
98Preaxial foot polydactyly (HP:0001841)1.63446067
99Median cleft lip (HP:0000161)1.62232314
100Abolished electroretinogram (ERG) (HP:0000550)1.62187028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.80802457
2TRIM283.05117183
3WNK33.02864730
4SRPK13.00964804
5WEE12.61391068
6BUB12.43235299
7ZAK2.30910598
8MKNK12.30803491
9MKNK22.30601490
10PLK42.30426024
11NUAK12.21828667
12TTK2.20529700
13NEK12.15401532
14TNIK1.97391556
15PLK31.97382507
16BMPR1B1.92809478
17VRK21.91554009
18VRK11.84643435
19PBK1.83410095
20BCR1.80072045
21TSSK61.79643625
22CASK1.77693736
23STK38L1.73300856
24TAF11.72631903
25EPHA41.68547189
26ACVR1B1.66321090
27MAP3K41.62620141
28PNCK1.59229409
29MAP4K21.52238882
30BRSK21.51023843
31PLK11.50184416
32DYRK21.40424602
33DYRK31.36358546
34CDK191.35396910
35MAPK131.21900770
36STK161.18549025
37NEK21.18289302
38FRK1.15573848
39ATR1.15055797
40MAP3K101.10009463
41TGFBR11.05449553
42CHEK21.04066329
43CSNK1G11.03742561
44MAP2K71.03390394
45PASK1.00283781
46MST40.98351645
47CSNK1G20.97442794
48EIF2AK30.97188502
49GRK10.90322443
50PLK20.89074287
51FGFR20.89015562
52INSRR0.88305539
53CSNK1G30.87353317
54CCNB10.86704830
55MARK10.85642717
56AURKB0.81847149
57BRSK10.79588865
58RPS6KA40.77400849
59ATM0.76599329
60ERBB30.74982537
61NME10.72812946
62CSNK1A1L0.72336797
63PINK10.69796848
64ERBB40.68575889
65PRKCG0.66678723
66BCKDK0.66345115
67EIF2AK20.65613964
68TIE10.61953962
69STK30.61769275
70CDK30.60079955
71CHEK10.57852069
72FLT30.57851636
73LATS10.55160698
74CAMK1G0.54800533
75TLK10.53574968
76BRD40.50177620
77OXSR10.50011601
78NTRK20.48971771
79FGFR10.48663491
80CDK70.47179241
81STK390.46354015
82UHMK10.45336103
83CDK10.44604858
84PKN10.43348135
85EPHB20.42357647
86MINK10.42149451
87CSNK2A10.41644699
88PRKCE0.41062408
89PRKDC0.39789409
90NLK0.39409187
91AURKA0.38760929
92ADRBK20.38756938
93CDK20.37789333
94CAMK1D0.37338797
95PAK30.37035485
96MELK0.35689515
97WNK40.35615069
98DYRK1A0.35214604
99CSNK1E0.34568235
100OBSCN0.33367606

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.73046097
2DNA replication_Homo sapiens_hsa030303.52996571
3Homologous recombination_Homo sapiens_hsa034403.32399102
4Fanconi anemia pathway_Homo sapiens_hsa034603.12622366
5Non-homologous end-joining_Homo sapiens_hsa034502.93569092
6Protein export_Homo sapiens_hsa030602.58828456
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.35971434
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32758363
9Base excision repair_Homo sapiens_hsa034102.27197257
10Steroid biosynthesis_Homo sapiens_hsa001002.27047088
11Cell cycle_Homo sapiens_hsa041102.12781282
12RNA polymerase_Homo sapiens_hsa030202.09489395
13Nucleotide excision repair_Homo sapiens_hsa034202.02070971
14Proteasome_Homo sapiens_hsa030502.00659340
15Propanoate metabolism_Homo sapiens_hsa006401.99714288
16Spliceosome_Homo sapiens_hsa030401.97593042
17RNA transport_Homo sapiens_hsa030131.96475001
18Basal transcription factors_Homo sapiens_hsa030221.93496096
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90356551
20RNA degradation_Homo sapiens_hsa030181.90234083
21Oxidative phosphorylation_Homo sapiens_hsa001901.67590751
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.58859312
23Parkinsons disease_Homo sapiens_hsa050121.57608809
24Basal cell carcinoma_Homo sapiens_hsa052171.52306396
25Ribosome_Homo sapiens_hsa030101.47420639
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45727819
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43852737
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41003955
29One carbon pool by folate_Homo sapiens_hsa006701.36047850
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34821598
31Hedgehog signaling pathway_Homo sapiens_hsa043401.30652431
32Huntingtons disease_Homo sapiens_hsa050161.30029213
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28927877
34Butanoate metabolism_Homo sapiens_hsa006501.25779356
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22960648
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19249235
37mRNA surveillance pathway_Homo sapiens_hsa030151.16136931
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15733779
39Pyrimidine metabolism_Homo sapiens_hsa002401.14503206
40Fatty acid elongation_Homo sapiens_hsa000621.07437187
41Oocyte meiosis_Homo sapiens_hsa041141.07223164
42Pyruvate metabolism_Homo sapiens_hsa006201.05165568
43Selenocompound metabolism_Homo sapiens_hsa004501.04756828
44Purine metabolism_Homo sapiens_hsa002301.03825914
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00273943
46Nicotine addiction_Homo sapiens_hsa050330.99440343
47Phototransduction_Homo sapiens_hsa047440.98021842
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90092627
49p53 signaling pathway_Homo sapiens_hsa041150.88978755
50Hippo signaling pathway_Homo sapiens_hsa043900.88775288
51Wnt signaling pathway_Homo sapiens_hsa043100.83989533
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82654814
53TGF-beta signaling pathway_Homo sapiens_hsa043500.81021354
54Taste transduction_Homo sapiens_hsa047420.80164287
55Alzheimers disease_Homo sapiens_hsa050100.79692155
56Folate biosynthesis_Homo sapiens_hsa007900.76823005
57Glutathione metabolism_Homo sapiens_hsa004800.75767863
58Peroxisome_Homo sapiens_hsa041460.74882460
59Biosynthesis of amino acids_Homo sapiens_hsa012300.70804073
60Nitrogen metabolism_Homo sapiens_hsa009100.70442160
61Vitamin B6 metabolism_Homo sapiens_hsa007500.67329005
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65403486
63Fatty acid metabolism_Homo sapiens_hsa012120.64719036
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62425492
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61670816
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59617218
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59485025
68Alcoholism_Homo sapiens_hsa050340.58543918
69Metabolic pathways_Homo sapiens_hsa011000.58333452
70Tryptophan metabolism_Homo sapiens_hsa003800.57668844
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57109231
72Cardiac muscle contraction_Homo sapiens_hsa042600.55972879
73Vitamin digestion and absorption_Homo sapiens_hsa049770.54766458
74Lysine degradation_Homo sapiens_hsa003100.54746362
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54626651
76Olfactory transduction_Homo sapiens_hsa047400.53874157
77beta-Alanine metabolism_Homo sapiens_hsa004100.51935463
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50281478
79Fatty acid degradation_Homo sapiens_hsa000710.50101140
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48406065
81Caffeine metabolism_Homo sapiens_hsa002320.48226128
82Carbon metabolism_Homo sapiens_hsa012000.46454045
83Systemic lupus erythematosus_Homo sapiens_hsa053220.41936513
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.41935986
85Retinol metabolism_Homo sapiens_hsa008300.41652960
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37226134
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36546737
88Arginine and proline metabolism_Homo sapiens_hsa003300.36124927
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.35756490
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33257188
91Regulation of autophagy_Homo sapiens_hsa041400.31840080
92Fat digestion and absorption_Homo sapiens_hsa049750.31143474
93Axon guidance_Homo sapiens_hsa043600.27691137
94Tight junction_Homo sapiens_hsa045300.26777338
95Chemical carcinogenesis_Homo sapiens_hsa052040.25804781
96Melanogenesis_Homo sapiens_hsa049160.24619248
97MicroRNAs in cancer_Homo sapiens_hsa052060.23576834
98N-Glycan biosynthesis_Homo sapiens_hsa005100.22357767
99Linoleic acid metabolism_Homo sapiens_hsa005910.20966328
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20887507

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