ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axoneme assembly (GO:0035082)	4.46000944
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.29040048
3	regulation of glucokinase activity (GO:0033131)	4.17876139
4	regulation of hexokinase activity (GO:1903299)	4.17876139
5	adaptation of signaling pathway (GO:0023058)	4.07585821
6	protein K6-linked ubiquitination (GO:0085020)	4.05414927
7	interleukin-6-mediated signaling pathway (GO:0070102)	3.86390608
8	sulfation (GO:0051923)	3.79014608
9	protein-chromophore linkage (GO:0018298)	3.72766207
10	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.71985187
11	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.64794513
12	detection of light stimulus involved in visual perception (GO:0050908)	3.58453313
13	detection of light stimulus involved in sensory perception (GO:0050962)	3.58453313
14	positive regulation of DNA-templated transcription, initiation (GO:2000144)	3.52939051
15	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	3.40776186
16	reciprocal meiotic recombination (GO:0007131)	3.40484576
17	reciprocal DNA recombination (GO:0035825)	3.40484576
18	centriole replication (GO:0007099)	3.38990655
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.38719609
20	neuron fate determination (GO:0048664)	3.38500741
21	peristalsis (GO:0030432)	3.34217866
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.33973573
23	protein-cofactor linkage (GO:0018065)	3.31442693
24	DNA deamination (GO:0045006)	3.28597275
25	tryptophan catabolic process (GO:0006569)	3.25985525
26	indole-containing compound catabolic process (GO:0042436)	3.25985525
27	indolalkylamine catabolic process (GO:0046218)	3.25985525
28	positive regulation of mitochondrial fission (GO:0090141)	3.23033728
29	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.21446363
30	fucosylation (GO:0036065)	3.20175700
31	proline transport (GO:0015824)	3.20020558
32	regulation of cell maturation (GO:1903429)	3.12490831
33	neuronal action potential (GO:0019228)	3.10937182
34	piRNA metabolic process (GO:0034587)	3.10059043
35	preassembly of GPI anchor in ER membrane (GO:0016254)	3.08655795
36	negative regulation of multicellular organism growth (GO:0040015)	3.03180185
37	acrosome reaction (GO:0007340)	3.03052217
38	inner ear receptor stereocilium organization (GO:0060122)	3.00857761
39	regulation of acrosome reaction (GO:0060046)	2.99300441
40	negative regulation of mast cell activation (GO:0033004)	2.98779225
41	fucose catabolic process (GO:0019317)	2.97731286
42	L-fucose metabolic process (GO:0042354)	2.97731286
43	L-fucose catabolic process (GO:0042355)	2.97731286
44	ER overload response (GO:0006983)	2.95962468
45	ventricular septum development (GO:0003281)	2.94910117
46	organic cation transport (GO:0015695)	2.94600316
47	protein K11-linked deubiquitination (GO:0035871)	2.92813702
48	regulation of cilium movement (GO:0003352)	2.90107213
49	NAD biosynthetic process (GO:0009435)	2.87954513
50	positive regulation of histone H3-K4 methylation (GO:0051571)	2.87272119
51	deoxyribose phosphate biosynthetic process (GO:0046385)	2.87201646
52	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.87201646
53	dopamine transport (GO:0015872)	2.86835722
54	kynurenine metabolic process (GO:0070189)	2.86050199
55	base-excision repair, AP site formation (GO:0006285)	2.84684865
56	spinal cord motor neuron differentiation (GO:0021522)	2.80158099
57	photoreceptor cell maintenance (GO:0045494)	2.80087942
58	respiratory chain complex IV assembly (GO:0008535)	2.79222448
59	spliceosomal complex assembly (GO:0000245)	2.79085712
60	C-terminal protein amino acid modification (GO:0018410)	2.77842933
61	cellular ketone body metabolic process (GO:0046950)	2.75887584
62	protein localization to microtubule cytoskeleton (GO:0072698)	2.75586421
63	RNA destabilization (GO:0050779)	2.74258767
64	regulation of neurotransmitter uptake (GO:0051580)	2.73765801
65	photoreceptor cell development (GO:0042461)	2.71132278
66	histone H3-K4 trimethylation (GO:0080182)	2.69996133
67	phasic smooth muscle contraction (GO:0014821)	2.67977454
68	indolalkylamine metabolic process (GO:0006586)	2.67500113
69	behavioral response to nicotine (GO:0035095)	2.67327336
70	response to folic acid (GO:0051593)	2.66137180
71	peptidyl-threonine dephosphorylation (GO:0035970)	2.66100818
72	artery development (GO:0060840)	2.64919103
73	spermatid nucleus differentiation (GO:0007289)	2.63880153
74	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.62068163
75	GPI anchor metabolic process (GO:0006505)	2.61661567
76	regulation of oligodendrocyte differentiation (GO:0048713)	2.61292696
77	negative regulation of systemic arterial blood pressure (GO:0003085)	2.61210013
78	ketone body metabolic process (GO:1902224)	2.57836474
79	eye photoreceptor cell development (GO:0042462)	2.56959251
80	mannosylation (GO:0097502)	2.56897488
81	double-strand break repair via homologous recombination (GO:0000724)	2.55338199
82	aggressive behavior (GO:0002118)	2.55130337
83	recombinational repair (GO:0000725)	2.53715906
84	platelet dense granule organization (GO:0060155)	2.53492167
85	DNA double-strand break processing (GO:0000729)	2.51489369
86	glycine transport (GO:0015816)	2.51358938
87	regulation of mitochondrial fission (GO:0090140)	2.50718439
88	T-helper cell differentiation (GO:0042093)	2.49612694
89	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.49612694
90	tryptophan metabolic process (GO:0006568)	2.48966644
91	adult feeding behavior (GO:0008343)	2.48015140
92	negative regulation of astrocyte differentiation (GO:0048712)	2.47968462
93	urinary tract smooth muscle contraction (GO:0014848)	2.45050635
94	cytoplasmic mRNA processing body assembly (GO:0033962)	2.43980945
95	nucleotide transmembrane transport (GO:1901679)	2.43268577
96	spermatid development (GO:0007286)	2.40412907
97	histone-serine phosphorylation (GO:0035404)	2.39537559
98	single strand break repair (GO:0000012)	2.39191853
99	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.38863569
100	cellular response to ATP (GO:0071318)	2.38734240

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.57459258
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.78114677
3	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.52986947
4	EWS_26573619_Chip-Seq_HEK293_Human	2.47699881
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40908631
6	IRF1_19129219_ChIP-ChIP_H3396_Human	2.32858702
7	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.32671163
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.29594690
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29271817
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.23550346
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.21254972
12	FUS_26573619_Chip-Seq_HEK293_Human	2.08839085
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.07262840
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.05128309
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00636501
16	P300_19829295_ChIP-Seq_ESCs_Human	1.95027881
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94988135
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.92769579
19	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.88609845
20	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.88609845
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.87239382
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.87239382
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.84043796
24	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.83693240
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83654702
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75410039
27	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.68700227
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68018291
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.66906988
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.66009021
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59710251
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.57519377
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51454981
34	NCOR_22424771_ChIP-Seq_293T_Human	1.50206390
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.50141838
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49722610
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48826206
38	TCF4_22108803_ChIP-Seq_LS180_Human	1.48079825
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.47636042
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.46864643
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46562547
42	TCF4_23295773_ChIP-Seq_U87_Human	1.46246552
43	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.46138799
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.41689960
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.40843048
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40588645
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.40221505
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.39188886
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37591674
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37591674
51	STAT3_23295773_ChIP-Seq_U87_Human	1.35986908
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.35602902
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.35362892
54	CDX2_22108803_ChIP-Seq_LS180_Human	1.29454943
55	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.29377763
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28432464
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27989609
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27039591
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26161781
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25717862
61	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25503640
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24873234
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23742153
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21104568
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19862175
66	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.19247509
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.18396403
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17948579
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15336780
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14105806
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13417225
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13128195
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12887681
74	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10479675
75	AR_20517297_ChIP-Seq_VCAP_Human	1.09828065
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.09501287
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09137958
78	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.09107339
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08446423
80	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06976809
81	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06692435
82	MYC_19829295_ChIP-Seq_ESCs_Human	1.06134526
83	PHF8_20622853_ChIP-Seq_HELA_Human	1.05998626
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05804364
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05391366
86	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05171238
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03955046
88	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02821662
89	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02805936
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02702483
91	EZH2_22144423_ChIP-Seq_EOC_Human	1.02625712
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02111108
93	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.01667354
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01502187
95	AR_25329375_ChIP-Seq_VCAP_Human	1.01406431
96	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01110292
97	NFYB_21822215_ChIP-Seq_K562_Human	1.00735568
98	TBL1_22424771_ChIP-Seq_293T_Human	1.00022469
99	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98990685
100	TAF15_26573619_Chip-Seq_HEK293_Human	0.98821693

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.11939290
2	MP0004885_abnormal_endolymph	3.55948885
3	MP0008877_abnormal_DNA_methylation	3.53339453
4	MP0003195_calcinosis	3.18753362
5	MP0002638_abnormal_pupillary_reflex	2.93148092
6	MP0006072_abnormal_retinal_apoptosis	2.89511063
7	MP0005365_abnormal_bile_salt	2.70496619
8	MP0001968_abnormal_touch/_nociception	2.52035002
9	MP0003693_abnormal_embryo_hatching	2.48932872
10	MP0001501_abnormal_sleep_pattern	2.45179120
11	MP0005551_abnormal_eye_electrophysiolog	2.40766023
12	MP0009780_abnormal_chondrocyte_physiolo	2.19939951
13	MP0003011_delayed_dark_adaptation	2.11977013
14	MP0000383_abnormal_hair_follicle	2.08386377
15	MP0008875_abnormal_xenobiotic_pharmacok	2.07245558
16	MP0005253_abnormal_eye_physiology	2.06882620
17	MP0001986_abnormal_taste_sensitivity	2.04832265
18	MP0000427_abnormal_hair_cycle	2.04001105
19	MP0006276_abnormal_autonomic_nervous	1.97674046
20	MP0003136_yellow_coat_color	1.95292248
21	MP0002160_abnormal_reproductive_system	1.90968868
22	MP0002102_abnormal_ear_morphology	1.81855885
23	MP0004147_increased_porphyrin_level	1.77865844
24	MP0003787_abnormal_imprinting	1.75975260
25	MP0005083_abnormal_biliary_tract	1.73823019
26	MP0003786_premature_aging	1.71093913
27	MP0002876_abnormal_thyroid_physiology	1.62913351
28	MP0005646_abnormal_pituitary_gland	1.58300049
29	MP0008007_abnormal_cellular_replicative	1.57054195
30	MP0000647_abnormal_sebaceous_gland	1.56908573
31	MP0003950_abnormal_plasma_membrane	1.52654998
32	MP0003880_abnormal_central_pattern	1.52554262
33	MP0008872_abnormal_physiological_respon	1.50783696
34	MP0008058_abnormal_DNA_repair	1.49488563
35	MP0002735_abnormal_chemical_nociception	1.46719063
36	MP0005389_reproductive_system_phenotype	1.46678340
37	MP0001502_abnormal_circadian_rhythm	1.45585865
38	MP0005410_abnormal_fertilization	1.45292752
39	MP0005645_abnormal_hypothalamus_physiol	1.43368185
40	MP0000569_abnormal_digit_pigmentation	1.37997426
41	MP0001929_abnormal_gametogenesis	1.31302870
42	MP0010678_abnormal_skin_adnexa	1.31296983
43	MP0008995_early_reproductive_senescence	1.30776681
44	MP0002272_abnormal_nervous_system	1.28694317
45	MP0002736_abnormal_nociception_after	1.25930449
46	MP0005084_abnormal_gallbladder_morpholo	1.24820100
47	MP0005085_abnormal_gallbladder_physiolo	1.19968942
48	MP0002751_abnormal_autonomic_nervous	1.15983697
49	MP0003283_abnormal_digestive_organ	1.15080946
50	MP0000372_irregular_coat_pigmentation	1.14657630
51	MP0001764_abnormal_homeostasis	1.12120604
52	MP0005174_abnormal_tail_pigmentation	1.11732636
53	MP0004742_abnormal_vestibular_system	1.11131845
54	MP0005386_behavior/neurological_phenoty	1.10776950
55	MP0004924_abnormal_behavior	1.10776950
56	MP0009745_abnormal_behavioral_response	1.10052540
57	MP0003698_abnormal_male_reproductive	1.08108784
58	MP0000631_abnormal_neuroendocrine_gland	1.06118685
59	MP0001963_abnormal_hearing_physiology	1.04608184
60	MP0009046_muscle_twitch	1.03247028
61	MP0003122_maternal_imprinting	1.02000449
62	MP0002572_abnormal_emotion/affect_behav	1.01872398
63	MP0000653_abnormal_sex_gland	1.01491918
64	MP0002557_abnormal_social/conspecific_i	1.01332267
65	MP0000026_abnormal_inner_ear	1.00244961
66	MP0010094_abnormal_chromosome_stability	0.99293555
67	MP0001485_abnormal_pinna_reflex	0.98553162
68	MP0004133_heterotaxia	0.96897349
69	MP0001145_abnormal_male_reproductive	0.96351852
70	MP0005379_endocrine/exocrine_gland_phen	0.96084161
71	MP0009764_decreased_sensitivity_to	0.92434354
72	MP0002210_abnormal_sex_determination	0.89119993
73	MP0001919_abnormal_reproductive_system	0.88684881
74	MP0002653_abnormal_ependyma_morphology	0.88187214
75	MP0001984_abnormal_olfaction	0.87142384
76	MP0000013_abnormal_adipose_tissue	0.86929020
77	MP0003638_abnormal_response/metabolism_	0.85934706
78	MP0002733_abnormal_thermal_nociception	0.84536007
79	MP0005171_absent_coat_pigmentation	0.84494000
80	MP0002938_white_spotting	0.84262076
81	MP0002277_abnormal_respiratory_mucosa	0.82390116
82	MP0001970_abnormal_pain_threshold	0.80599660
83	MP0002928_abnormal_bile_duct	0.80562275
84	MP0006292_abnormal_olfactory_placode	0.80238018
85	MP0001486_abnormal_startle_reflex	0.80003144
86	MP0005671_abnormal_response_to	0.79093057
87	MP0002098_abnormal_vibrissa_morphology	0.78045154
88	MP0005195_abnormal_posterior_eye	0.77357678
89	MP0010386_abnormal_urinary_bladder	0.76023061
90	MP0002229_neurodegeneration	0.75168921
91	MP0000685_abnormal_immune_system	0.73947665
92	MP0003121_genomic_imprinting	0.72361716
93	MP0004019_abnormal_vitamin_homeostasis	0.71393576
94	MP0002282_abnormal_trachea_morphology	0.68937526
95	MP0008789_abnormal_olfactory_epithelium	0.68417582
96	MP0003252_abnormal_bile_duct	0.67501666
97	MP0001879_abnormal_lymphatic_vessel	0.67366241
98	MP0002095_abnormal_skin_pigmentation	0.67286016
99	MP0000639_abnormal_adrenal_gland	0.63613390
100	MP0002837_dystrophic_cardiac_calcinosis	0.63407594

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.22205334
2	Abnormal rod and cone electroretinograms (HP:0008323)	4.96589275
3	Hyperventilation (HP:0002883)	4.53383049
4	Congenital stationary night blindness (HP:0007642)	4.19127061
5	Attenuation of retinal blood vessels (HP:0007843)	3.88063689
6	Decreased central vision (HP:0007663)	3.86855195
7	Pendular nystagmus (HP:0012043)	3.75317431
8	Constricted visual fields (HP:0001133)	3.72520210
9	Hypoplasia of the uterus (HP:0000013)	3.66851189
10	Optic nerve hypoplasia (HP:0000609)	3.33458034
11	Methylmalonic aciduria (HP:0012120)	3.32118881
12	Pancreatic cysts (HP:0001737)	3.26835408
13	Stomatitis (HP:0010280)	3.11658243
14	Stomach cancer (HP:0012126)	3.09372312
15	Optic disc pallor (HP:0000543)	3.06688275
16	True hermaphroditism (HP:0010459)	2.99584913
17	Aplasia/hypoplasia of the uterus (HP:0008684)	2.99441842
18	Hypokalemic alkalosis (HP:0001949)	2.97304998
19	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.92445841
20	Bony spicule pigmentary retinopathy (HP:0007737)	2.84879017
21	Dry hair (HP:0011359)	2.84392226
22	Abnormality of the renal cortex (HP:0011035)	2.84008618
23	Acute necrotizing encephalopathy (HP:0006965)	2.78300375
24	Medial flaring of the eyebrow (HP:0010747)	2.71622549
25	Nephronophthisis (HP:0000090)	2.68542084
26	Dyschromatopsia (HP:0007641)	2.65326951
27	Pancreatic fibrosis (HP:0100732)	2.64573347
28	Abnormality of the prostate (HP:0008775)	2.62637107
29	Abnormality of the renal medulla (HP:0100957)	2.60432631
30	Abolished electroretinogram (ERG) (HP:0000550)	2.53690039
31	Type II lissencephaly (HP:0007260)	2.41346771
32	Abnormality of macular pigmentation (HP:0008002)	2.38299300
33	Progressive macrocephaly (HP:0004481)	2.37893934
34	Severe visual impairment (HP:0001141)	2.37544296
35	Cerebellar dysplasia (HP:0007033)	2.37188921
36	Tubular atrophy (HP:0000092)	2.37128269
37	Increased corneal curvature (HP:0100692)	2.35700210
38	Keratoconus (HP:0000563)	2.35700210
39	Prostate neoplasm (HP:0100787)	2.34075622
40	Hypoplastic iliac wings (HP:0002866)	2.31086453
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.30427500
42	Lissencephaly (HP:0001339)	2.29032151
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.28869690
44	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.26204315
45	Molar tooth sign on MRI (HP:0002419)	2.25562546
46	Abnormality of midbrain morphology (HP:0002418)	2.25562546
47	Rib fusion (HP:0000902)	2.25292134
48	Polyuria (HP:0000103)	2.21072242
49	Acute encephalopathy (HP:0006846)	2.18040091
50	Abnormality of the nasal septum (HP:0000419)	2.16714839
51	Central scotoma (HP:0000603)	2.16187297
52	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.15518785
53	Short 1st metacarpal (HP:0010034)	2.15518785
54	Increased CSF lactate (HP:0002490)	2.13718183
55	Type II diabetes mellitus (HP:0005978)	2.08985175
56	Chronic bronchitis (HP:0004469)	2.08467530
57	Amelogenesis imperfecta (HP:0000705)	2.07062692
58	Absent speech (HP:0001344)	2.04679804
59	Septo-optic dysplasia (HP:0100842)	2.04622209
60	Abnormal drinking behavior (HP:0030082)	2.03684526
61	Polydipsia (HP:0001959)	2.03684526
62	Macular degeneration (HP:0000608)	2.03197372
63	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.02408935
64	Hypoplasia of the fovea (HP:0007750)	2.02408935
65	Mitochondrial inheritance (HP:0001427)	2.02103562
66	Colon cancer (HP:0003003)	2.00405308
67	Abnormality of male internal genitalia (HP:0000022)	1.98436913
68	Tubulointerstitial fibrosis (HP:0005576)	1.96283287
69	Abnormality of the fovea (HP:0000493)	1.93466722
70	Nephrogenic diabetes insipidus (HP:0009806)	1.92495251
71	Photophobia (HP:0000613)	1.91087604
72	Pachygyria (HP:0001302)	1.90937176
73	Volvulus (HP:0002580)	1.90921967
74	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.90484540
75	Abnormality of the 1st metacarpal (HP:0010009)	1.89201749
76	Congenital primary aphakia (HP:0007707)	1.86311159
77	Disproportionate short-trunk short stature (HP:0003521)	1.85242725
78	Hyperaldosteronism (HP:0000859)	1.84030325
79	Tubulointerstitial abnormality (HP:0001969)	1.84014892
80	Metabolic alkalosis (HP:0200114)	1.83200815
81	Unsteady gait (HP:0002317)	1.83175984
82	Retinitis pigmentosa (HP:0000510)	1.82911059
83	IgG deficiency (HP:0004315)	1.82096978
84	Gait imbalance (HP:0002141)	1.82020675
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79157453
86	Abnormality of alanine metabolism (HP:0010916)	1.79157453
87	Hyperalaninemia (HP:0003348)	1.79157453
88	Cystic liver disease (HP:0006706)	1.77694945
89	Decreased circulating renin level (HP:0003351)	1.76497700
90	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.76177665
91	Abnormality of serine family amino acid metabolism (HP:0010894)	1.75397730
92	Abnormality of glycine metabolism (HP:0010895)	1.75397730
93	Hypomagnesemia (HP:0002917)	1.75028215
94	Abnormal urine output (HP:0012590)	1.74435715
95	Radial bowing (HP:0002986)	1.71853593
96	Methylmalonic acidemia (HP:0002912)	1.71776346
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.70305099
98	Absent/shortened dynein arms (HP:0200106)	1.70305099
99	Abnormal number of erythroid precursors (HP:0012131)	1.69341540
100	Cone-rod dystrophy (HP:0000548)	1.67575033

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.79471285
2	CASK	3.94484886
3	NUAK1	3.10083292
4	FRK	2.93535178
5	TAF1	2.89050633
6	MARK1	2.86433498
7	VRK2	2.42927015
8	PINK1	2.36261702
9	TAOK3	2.29192987
10	GRK1	2.25456698
11	TESK2	2.17051992
12	PIK3CG	1.99197352
13	PNCK	1.70331490
14	MAP4K2	1.56983999
15	NTRK2	1.56812396
16	ADRBK2	1.51794018
17	STK38L	1.50130759
18	ZAK	1.44065551
19	TLK1	1.39871746
20	VRK1	1.34050185
21	MAP3K4	1.32237376
22	MAP3K12	1.30056815
23	OXSR1	1.29780219
24	TRIM28	1.28705693
25	IKBKB	1.28651605
26	TNIK	1.16542109
27	WNK3	1.15305543
28	INSRR	1.14816496
29	TIE1	1.13839421
30	MAPK13	1.09908925
31	MAP4K1	1.09456449
32	CDK8	1.09007373
33	NLK	1.02891317
34	GRK5	1.01117510
35	CSNK1G3	0.88763768
36	CHEK2	0.88083751
37	CSNK1G1	0.87525826
38	GRK6	0.87494488
39	WNK4	0.83410408
40	EPHA4	0.82171101
41	PRKCG	0.81748708
42	BUB1	0.80743545
43	ERBB3	0.80095044
44	AKT3	0.77046277
45	CSNK1G2	0.74282762
46	MATK	0.71992010
47	PRKCE	0.71441382
48	STK39	0.69907893
49	TEC	0.69279526
50	ARAF	0.68469641
51	WEE1	0.66433879
52	CDK19	0.65632305
53	CSNK1A1L	0.65113382
54	MUSK	0.59870609
55	MAP2K2	0.59831289
56	MAP3K13	0.59781502
57	FER	0.59589049
58	EIF2AK2	0.59285634
59	MYLK	0.58672788
60	MAPK4	0.57590576
61	PRKCH	0.56911995
62	DAPK1	0.55871327
63	IKBKE	0.54948005
64	PAK3	0.54878945
65	MAPKAPK5	0.54155865
66	AURKA	0.54148389
67	PLK4	0.54119992
68	ADRBK1	0.53666660
69	CDK9	0.53134925
70	PLK3	0.52406310
71	MARK3	0.50485125
72	GRK7	0.50069569
73	TBK1	0.49931999
74	KDR	0.49662284
75	NME1	0.47981117
76	NEK2	0.47703912
77	PKN1	0.47491445
78	PLK2	0.46758620
79	ABL1	0.44524034
80	ITK	0.44031914
81	BMPR1B	0.41131650
82	PRKG1	0.40737455
83	STK3	0.39741255
84	TXK	0.39635211
85	DYRK2	0.39357755
86	MAPK15	0.38802727
87	PAK1	0.37015278
88	PRKCI	0.36592127
89	FLT3	0.35798055
90	PIK3CA	0.35508164
91	EPHA3	0.34939880
92	MOS	0.34581701
93	CHUK	0.34300314
94	LIMK1	0.32817934
95	PRKACA	0.31182370
96	CSF1R	0.30601112
97	PTK2B	0.27923798
98	CSNK1D	0.27575065
99	IRAK1	0.27421662
100	PRKACB	0.27319110

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.20519946
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.97732181
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.88121021
4	Basal transcription factors_Homo sapiens_hsa03022	2.80757470
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.31741320
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.31501960
7	Propanoate metabolism_Homo sapiens_hsa00640	2.30501734
8	Phototransduction_Homo sapiens_hsa04744	2.27615731
9	Homologous recombination_Homo sapiens_hsa03440	2.22321112
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.22087571
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.17907953
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.16658605
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.06858575
14	One carbon pool by folate_Homo sapiens_hsa00670	2.01970863
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95533618
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.91314801
17	Butanoate metabolism_Homo sapiens_hsa00650	1.85612704
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.84088627
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.77650355
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71880449
21	Protein export_Homo sapiens_hsa03060	1.68585227
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.66339549
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.58453167
24	Taste transduction_Homo sapiens_hsa04742	1.51142848
25	Caffeine metabolism_Homo sapiens_hsa00232	1.48303072
26	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.44862751
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.37758147
28	Circadian rhythm_Homo sapiens_hsa04710	1.33740048
29	Proteasome_Homo sapiens_hsa03050	1.31268932
30	RNA polymerase_Homo sapiens_hsa03020	1.25697751
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21880742
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.20784695
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19936237
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18559173
35	Nicotine addiction_Homo sapiens_hsa05033	1.13043920
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12075407
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.11556371
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11488883
39	Parkinsons disease_Homo sapiens_hsa05012	1.10659550
40	Base excision repair_Homo sapiens_hsa03410	1.10561098
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10069473
42	RNA degradation_Homo sapiens_hsa03018	1.09418341
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.09264346
44	Retinol metabolism_Homo sapiens_hsa00830	1.07901579
45	Selenocompound metabolism_Homo sapiens_hsa00450	1.07581345
46	Asthma_Homo sapiens_hsa05310	1.04337454
47	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00625002
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99186410
49	Olfactory transduction_Homo sapiens_hsa04740	0.96072567
50	Sulfur relay system_Homo sapiens_hsa04122	0.92954611
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92889979
52	Regulation of autophagy_Homo sapiens_hsa04140	0.91153128
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90540248
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88375474
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.87860740
56	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82882707
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82251793
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82183038
59	Allograft rejection_Homo sapiens_hsa05330	0.81908791
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80857935
61	Folate biosynthesis_Homo sapiens_hsa00790	0.78734338
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78271614
63	Ribosome_Homo sapiens_hsa03010	0.76583095
64	Huntingtons disease_Homo sapiens_hsa05016	0.75665897
65	Morphine addiction_Homo sapiens_hsa05032	0.68776441
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68386428
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66070696
68	Mismatch repair_Homo sapiens_hsa03430	0.65739374
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62026253
70	Alzheimers disease_Homo sapiens_hsa05010	0.61068409
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60732705
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.60619298
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.59593339
74	GABAergic synapse_Homo sapiens_hsa04727	0.59120929
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58357661
76	Salivary secretion_Homo sapiens_hsa04970	0.56495074
77	Mineral absorption_Homo sapiens_hsa04978	0.56320334
78	Purine metabolism_Homo sapiens_hsa00230	0.55733510
79	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.54382259
80	RNA transport_Homo sapiens_hsa03013	0.54055551
81	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52575659
82	Metabolic pathways_Homo sapiens_hsa01100	0.52352348
83	Lysine degradation_Homo sapiens_hsa00310	0.51891381
84	ABC transporters_Homo sapiens_hsa02010	0.47122985
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45682395
86	Glutathione metabolism_Homo sapiens_hsa00480	0.43806495
87	Legionellosis_Homo sapiens_hsa05134	0.42093355
88	p53 signaling pathway_Homo sapiens_hsa04115	0.39902245
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.39695668
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38928013
91	Peroxisome_Homo sapiens_hsa04146	0.38865923
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35972924
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35234666
94	DNA replication_Homo sapiens_hsa03030	0.35185697
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33875476
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33004383
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.31933899
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29729797
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.25805853
100	Insulin secretion_Homo sapiens_hsa04911	0.23929835

ZNF736P9Y

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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