ZNF738

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.15712250
2chromatin remodeling at centromere (GO:0031055)3.85911025
3behavioral response to nicotine (GO:0035095)3.69401085
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58788584
5DNA double-strand break processing (GO:0000729)3.55722898
6CENP-A containing nucleosome assembly (GO:0034080)3.50492875
7DNA damage response, detection of DNA damage (GO:0042769)3.38111523
8ATP synthesis coupled proton transport (GO:0015986)3.31856320
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31856320
10nucleobase catabolic process (GO:0046113)3.27188336
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.21936408
12presynaptic membrane assembly (GO:0097105)3.17420733
13sequestering of actin monomers (GO:0042989)3.16438952
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15175534
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.15175534
16NADH dehydrogenase complex assembly (GO:0010257)3.15175534
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14269151
18regulation of mitotic spindle checkpoint (GO:1903504)3.14269151
19protein complex biogenesis (GO:0070271)3.12713889
20nonmotile primary cilium assembly (GO:0035058)3.12516394
21chaperone-mediated protein transport (GO:0072321)3.09816696
22histone exchange (GO:0043486)3.07556382
23protein-cofactor linkage (GO:0018065)3.05027338
24protein neddylation (GO:0045116)3.03940509
25mitochondrial respiratory chain complex assembly (GO:0033108)3.03684300
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.00335604
27intraciliary transport (GO:0042073)2.94615993
28replication fork processing (GO:0031297)2.92233567
29limb bud formation (GO:0060174)2.91635524
30neural tube formation (GO:0001841)2.91416297
31ribosomal small subunit assembly (GO:0000028)2.89476347
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88113008
33presynaptic membrane organization (GO:0097090)2.88032247
34epithelial cilium movement (GO:0003351)2.87451312
35centriole replication (GO:0007099)2.87308901
36negative regulation of translation, ncRNA-mediated (GO:0040033)2.87047072
37regulation of translation, ncRNA-mediated (GO:0045974)2.87047072
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87047072
39regulation of gene silencing by RNA (GO:0060966)2.86950108
40regulation of posttranscriptional gene silencing (GO:0060147)2.86950108
41regulation of gene silencing by miRNA (GO:0060964)2.86950108
42somite development (GO:0061053)2.86554022
43DNA replication-independent nucleosome assembly (GO:0006336)2.85220721
44DNA replication-independent nucleosome organization (GO:0034724)2.85220721
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84895878
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84160738
47regulation of helicase activity (GO:0051095)2.83477196
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80020538
49retinal ganglion cell axon guidance (GO:0031290)2.77410968
50cell proliferation in forebrain (GO:0021846)2.77305547
51kidney morphogenesis (GO:0060993)2.76925956
52olfactory bulb development (GO:0021772)2.76015067
53somatic hypermutation of immunoglobulin genes (GO:0016446)2.75368024
54somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75368024
55negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74848551
56somite rostral/caudal axis specification (GO:0032525)2.72281912
57DNA replication checkpoint (GO:0000076)2.70022133
58negative regulation of telomere maintenance (GO:0032205)2.66576350
59regulation of nuclear cell cycle DNA replication (GO:0033262)2.62897544
60water-soluble vitamin biosynthetic process (GO:0042364)2.59388724
61platelet dense granule organization (GO:0060155)2.58293172
62neuron fate determination (GO:0048664)2.50856062
63postsynaptic membrane organization (GO:0001941)2.50438154
64protein polyglutamylation (GO:0018095)2.48642102
65regulation of development, heterochronic (GO:0040034)2.47780009
66hindbrain development (GO:0030902)2.47120741
67negative regulation of DNA recombination (GO:0045910)2.45583114
68regulation of telomere maintenance (GO:0032204)2.44779726
69spinal cord development (GO:0021510)2.44199494
70microtubule depolymerization (GO:0007019)2.44095003
71neuron cell-cell adhesion (GO:0007158)2.42353766
72kinetochore assembly (GO:0051382)2.42339684
73termination of RNA polymerase III transcription (GO:0006386)2.41621487
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.41621487
75protein K6-linked ubiquitination (GO:0085020)2.41440075
76maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41115699
77protein localization to cilium (GO:0061512)2.40415255
78kinetochore organization (GO:0051383)2.39631889
79spliceosomal snRNP assembly (GO:0000387)2.37525613
80resolution of meiotic recombination intermediates (GO:0000712)2.37324739
81translational termination (GO:0006415)2.36991967
82cilium morphogenesis (GO:0060271)2.36274870
83recombinational repair (GO:0000725)2.35746253
84DNA replication-dependent nucleosome organization (GO:0034723)2.35551940
85DNA replication-dependent nucleosome assembly (GO:0006335)2.35551940
86electron transport chain (GO:0022900)2.35355181
87respiratory electron transport chain (GO:0022904)2.34931321
88regulation of meiosis I (GO:0060631)2.34159110
89transmission of nerve impulse (GO:0019226)2.33743655
90head development (GO:0060322)2.33420989
91ncRNA catabolic process (GO:0034661)2.32138647
92cornea development in camera-type eye (GO:0061303)2.31600307
93viral transcription (GO:0019083)2.31083489
94otic vesicle formation (GO:0030916)2.31001189
95regulation of timing of cell differentiation (GO:0048505)2.30977440
96double-strand break repair via homologous recombination (GO:0000724)2.30336965
97reciprocal meiotic recombination (GO:0007131)2.27935358
98reciprocal DNA recombination (GO:0035825)2.27935358
99regulation of cilium movement (GO:0003352)2.26873346
100regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.26254923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.28713257
2* ZNF274_21170338_ChIP-Seq_K562_Hela3.17870234
3EZH2_22144423_ChIP-Seq_EOC_Human3.02697977
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.83885838
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83724262
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76542474
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73878338
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55059172
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.53453199
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.53374049
11IGF1R_20145208_ChIP-Seq_DFB_Human2.44981852
12VDR_22108803_ChIP-Seq_LS180_Human2.42348937
13EWS_26573619_Chip-Seq_HEK293_Human2.39695806
14FUS_26573619_Chip-Seq_HEK293_Human2.35798235
15TAF15_26573619_Chip-Seq_HEK293_Human2.29836323
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26049984
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18798349
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17285080
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10728516
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07971712
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07329052
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05027600
23GBX2_23144817_ChIP-Seq_PC3_Human2.02393404
24IRF1_19129219_ChIP-ChIP_H3396_Human1.94926357
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91168042
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86668980
27ELK1_19687146_ChIP-ChIP_HELA_Human1.86000924
28P300_19829295_ChIP-Seq_ESCs_Human1.85436739
29MYC_18940864_ChIP-ChIP_HL60_Human1.79363244
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.70706192
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68519940
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.68472743
33SOX2_16153702_ChIP-ChIP_HESCs_Human1.65942202
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.59126682
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55289166
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55055767
37E2F7_22180533_ChIP-Seq_HELA_Human1.54900542
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53458530
39RNF2_27304074_Chip-Seq_NSC_Mouse1.51459643
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51065416
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.49151945
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47348067
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46392005
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45411852
45VDR_23849224_ChIP-Seq_CD4+_Human1.38607752
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33003106
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33003106
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28041533
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.26301027
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26255110
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25034144
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.24963363
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22780581
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21397877
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.20207082
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19988706
57REST_21632747_ChIP-Seq_MESCs_Mouse1.19431776
58FOXP3_21729870_ChIP-Seq_TREG_Human1.18938687
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18273027
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16171357
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16089005
62TP53_22573176_ChIP-Seq_HFKS_Human1.14856307
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.14287083
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14105671
65CBP_20019798_ChIP-Seq_JUKART_Human1.14105671
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13925186
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09997609
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09554586
69ER_23166858_ChIP-Seq_MCF-7_Human1.07723871
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06928918
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.06524767
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06500217
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06359658
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.06233975
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05781825
76SMAD4_21799915_ChIP-Seq_A2780_Human1.05658637
77TTF2_22483619_ChIP-Seq_HELA_Human1.04829059
78AR_25329375_ChIP-Seq_VCAP_Human1.04189775
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04042968
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03957792
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03750619
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03709985
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03306863
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01487398
85EZH2_27304074_Chip-Seq_ESCs_Mouse0.99537618
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99194629
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98619266
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98293359
89RUNX2_22187159_ChIP-Seq_PCA_Human0.97375845
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96625691
91BCAT_22108803_ChIP-Seq_LS180_Human0.94744710
92NANOG_19829295_ChIP-Seq_ESCs_Human0.94224708
93SOX2_19829295_ChIP-Seq_ESCs_Human0.94224708
94TCF4_22108803_ChIP-Seq_LS180_Human0.93758024
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92372501
96STAT3_23295773_ChIP-Seq_U87_Human0.92156144
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91495697
98TCF4_23295773_ChIP-Seq_U87_Human0.90963781
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.90601711
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89864828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.78293049
2MP0008877_abnormal_DNA_methylation2.85991797
3MP0003880_abnormal_central_pattern2.73222691
4MP0003890_abnormal_embryonic-extraembry2.25825071
5MP0001529_abnormal_vocalization2.19947978
6MP0003122_maternal_imprinting2.18887789
7MP0003121_genomic_imprinting2.15664291
8MP0008789_abnormal_olfactory_epithelium2.10900000
9MP0003787_abnormal_imprinting2.09557392
10MP0002102_abnormal_ear_morphology2.08080723
11MP0003136_yellow_coat_color2.04615709
12MP0006072_abnormal_retinal_apoptosis2.01781463
13MP0002938_white_spotting2.01625515
14MP0001293_anophthalmia2.01221202
15MP0004133_heterotaxia2.00365093
16MP0005499_abnormal_olfactory_system1.96695776
17MP0005394_taste/olfaction_phenotype1.96695776
18MP0008058_abnormal_DNA_repair1.94754969
19MP0006276_abnormal_autonomic_nervous1.92552004
20MP0000778_abnormal_nervous_system1.90009820
21MP0002653_abnormal_ependyma_morphology1.78930519
22MP0001984_abnormal_olfaction1.74145754
23MP0000566_synostosis1.70189856
24MP0000631_abnormal_neuroendocrine_gland1.67400714
25MP0002751_abnormal_autonomic_nervous1.65221791
26MP0009379_abnormal_foot_pigmentation1.63608961
27MP0003718_maternal_effect1.60979629
28MP0003693_abnormal_embryo_hatching1.60488342
29MP0001188_hyperpigmentation1.60412384
30MP0003119_abnormal_digestive_system1.54942928
31MP0010030_abnormal_orbit_morphology1.52580952
32MP0005253_abnormal_eye_physiology1.51557008
33MP0010094_abnormal_chromosome_stability1.50298766
34MP0002638_abnormal_pupillary_reflex1.49820058
35MP0002736_abnormal_nociception_after1.49250757
36MP0000049_abnormal_middle_ear1.49214662
37MP0003937_abnormal_limbs/digits/tail_de1.47206771
38MP0005551_abnormal_eye_electrophysiolog1.46161244
39MP0002234_abnormal_pharynx_morphology1.43529287
40MP0003567_abnormal_fetal_cardiomyocyte1.42914675
41MP0001968_abnormal_touch/_nociception1.28209477
42MP0003011_delayed_dark_adaptation1.28193261
43MP0003938_abnormal_ear_development1.27743314
44MP0001286_abnormal_eye_development1.27037186
45MP0001485_abnormal_pinna_reflex1.26267320
46MP0004142_abnormal_muscle_tone1.24770740
47MP0008995_early_reproductive_senescence1.24575043
48MP0002233_abnormal_nose_morphology1.23475102
49MP0009745_abnormal_behavioral_response1.21655430
50MP0009046_muscle_twitch1.21393340
51MP0002822_catalepsy1.21282711
52MP0001486_abnormal_startle_reflex1.20028377
53MP0002557_abnormal_social/conspecific_i1.16644541
54MP0002184_abnormal_innervation1.14647353
55MP0003123_paternal_imprinting1.14267502
56MP0002272_abnormal_nervous_system1.14246432
57MP0002752_abnormal_somatic_nervous1.12340648
58MP0003861_abnormal_nervous_system1.11714925
59MP0005391_vision/eye_phenotype1.09194586
60MP0004885_abnormal_endolymph1.08349134
61MP0008057_abnormal_DNA_replication1.07200551
62MP0005195_abnormal_posterior_eye1.05401687
63MP0000955_abnormal_spinal_cord1.03755531
64MP0008932_abnormal_embryonic_tissue1.02976616
65MP0000647_abnormal_sebaceous_gland1.02581020
66MP0005084_abnormal_gallbladder_morpholo1.02545198
67MP0002735_abnormal_chemical_nociception1.01591148
68MP0005645_abnormal_hypothalamus_physiol1.01236096
69MP0002254_reproductive_system_inflammat1.01177381
70MP0005423_abnormal_somatic_nervous1.00535784
71MP0002572_abnormal_emotion/affect_behav1.00136891
72MP0002210_abnormal_sex_determination0.98753182
73MP0002697_abnormal_eye_size0.98682529
74MP0009697_abnormal_copulation0.98159765
75MP0004742_abnormal_vestibular_system0.97890477
76MP0004957_abnormal_blastocyst_morpholog0.97176218
77MP0003283_abnormal_digestive_organ0.96685358
78MP0002734_abnormal_mechanical_nocicepti0.96330832
79MP0000026_abnormal_inner_ear0.94940652
80MP0002837_dystrophic_cardiac_calcinosis0.94411822
81MP0001299_abnormal_eye_distance/0.93983498
82MP0003755_abnormal_palate_morphology0.93918131
83MP0003195_calcinosis0.93739424
84MP0003635_abnormal_synaptic_transmissio0.92158823
85MP0005646_abnormal_pituitary_gland0.91976879
86MP0005187_abnormal_penis_morphology0.89583881
87MP0002067_abnormal_sensory_capabilities0.88938932
88MP0003111_abnormal_nucleus_morphology0.87336286
89MP0002152_abnormal_brain_morphology0.86996070
90MP0002882_abnormal_neuron_morphology0.86575217
91MP0002063_abnormal_learning/memory/cond0.86109149
92MP0003315_abnormal_perineum_morphology0.85756155
93MP0000569_abnormal_digit_pigmentation0.85737422
94MP0000653_abnormal_sex_gland0.84714876
95MP0003698_abnormal_male_reproductive0.82843630
96MP0002064_seizures0.82488761
97MP0002160_abnormal_reproductive_system0.82398577
98MP0001145_abnormal_male_reproductive0.82191488
99MP0001346_abnormal_lacrimal_gland0.81133253
100MP0003077_abnormal_cell_cycle0.80034195

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.48392560
2Colon cancer (HP:0003003)3.46423067
3Pancreatic cysts (HP:0001737)3.46398625
4Abnormality of the labia minora (HP:0012880)3.44901177
5True hermaphroditism (HP:0010459)3.43892132
6Abnormality of midbrain morphology (HP:0002418)3.22329770
7Molar tooth sign on MRI (HP:0002419)3.22329770
8Nephronophthisis (HP:0000090)2.95180770
9Medial flaring of the eyebrow (HP:0010747)2.80592190
10Septo-optic dysplasia (HP:0100842)2.79340587
11Intestinal atresia (HP:0011100)2.56313698
12Gait imbalance (HP:0002141)2.54793992
13Acute necrotizing encephalopathy (HP:0006965)2.51936577
14Reticulocytopenia (HP:0001896)2.50145254
15Hyperglycinemia (HP:0002154)2.48133797
16Congenital primary aphakia (HP:0007707)2.45405784
17Pendular nystagmus (HP:0012043)2.44069792
18Meckel diverticulum (HP:0002245)2.41988792
19Anophthalmia (HP:0000528)2.41794224
20Abnormality of the renal medulla (HP:0100957)2.41380272
21Optic nerve hypoplasia (HP:0000609)2.39563405
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.39486194
23Oligodactyly (hands) (HP:0001180)2.36548112
24Anencephaly (HP:0002323)2.35941175
25Abnormality of the ileum (HP:0001549)2.34198102
26Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32669589
27Acute encephalopathy (HP:0006846)2.32189910
28Nephrogenic diabetes insipidus (HP:0009806)2.30465707
29Genital tract atresia (HP:0001827)2.29199372
30Vaginal atresia (HP:0000148)2.27011840
31Chronic hepatic failure (HP:0100626)2.24548855
32Lissencephaly (HP:0001339)2.23394719
33Triphalangeal thumb (HP:0001199)2.23342186
34Supernumerary spleens (HP:0009799)2.21479001
35Mitochondrial inheritance (HP:0001427)2.21160631
36Sclerocornea (HP:0000647)2.20879658
37Cystic liver disease (HP:0006706)2.14366661
38Type II lissencephaly (HP:0007260)2.12552500
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.11453926
40Preaxial hand polydactyly (HP:0001177)2.09392721
41Abnormal mitochondria in muscle tissue (HP:0008316)2.07782644
42Increased hepatocellular lipid droplets (HP:0006565)2.07162255
43Postaxial foot polydactyly (HP:0001830)2.06103770
44Progressive macrocephaly (HP:0004481)2.05820026
45Rib fusion (HP:0000902)2.04141974
46Patellar aplasia (HP:0006443)2.03012556
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02471688
48Dandy-Walker malformation (HP:0001305)2.02342320
49Increased CSF lactate (HP:0002490)2.01588874
50Abnormal biliary tract physiology (HP:0012439)2.00925991
51Bile duct proliferation (HP:0001408)2.00925991
52Abnormal lung lobation (HP:0002101)2.00080823
53Chromsome breakage (HP:0040012)2.00063257
54Abnormality of chromosome stability (HP:0003220)1.99235517
55Absent septum pellucidum (HP:0001331)1.98386736
56Oligodactyly (HP:0012165)1.97959578
57Lipid accumulation in hepatocytes (HP:0006561)1.95794031
58Ectopic kidney (HP:0000086)1.95142997
59Postaxial hand polydactyly (HP:0001162)1.94481840
60Esophageal atresia (HP:0002032)1.92633422
61Abnormal number of erythroid precursors (HP:0012131)1.92281748
62Methylmalonic acidemia (HP:0002912)1.90874336
63Limb dystonia (HP:0002451)1.90795977
64Aplasia/Hypoplasia of the patella (HP:0006498)1.87742002
65Congenital stationary night blindness (HP:0007642)1.87516740
66Gastrointestinal atresia (HP:0002589)1.86874156
67Cortical dysplasia (HP:0002539)1.86865439
68Hepatocellular necrosis (HP:0001404)1.86688584
69Poor coordination (HP:0002370)1.86158152
70Bilateral microphthalmos (HP:0007633)1.84654277
71Growth hormone deficiency (HP:0000824)1.84081272
72Cerebellar dysplasia (HP:0007033)1.83493245
73Aqueductal stenosis (HP:0002410)1.81362670
74Hyperglycinuria (HP:0003108)1.78437469
75Abolished electroretinogram (ERG) (HP:0000550)1.77801224
76Abnormality of cells of the erythroid lineage (HP:0012130)1.76040444
77Stenosis of the external auditory canal (HP:0000402)1.75549118
78Male pseudohermaphroditism (HP:0000037)1.75381699
79Tubular atrophy (HP:0000092)1.74822709
80Birth length less than 3rd percentile (HP:0003561)1.74757742
81Abnormality of the renal cortex (HP:0011035)1.74628520
82Abnormality of the duodenum (HP:0002246)1.74183733
83Narrow forehead (HP:0000341)1.72413763
84Hyperventilation (HP:0002883)1.71549391
85Sloping forehead (HP:0000340)1.71464757
86Retinal dysplasia (HP:0007973)1.70470464
87Broad-based gait (HP:0002136)1.69307687
88Drooling (HP:0002307)1.68928525
89Hemivertebrae (HP:0002937)1.68521677
90Abnormality of the septum pellucidum (HP:0007375)1.68391256
91Aplasia involving forearm bones (HP:0009822)1.67957418
92Absent forearm bone (HP:0003953)1.67957418
93Inability to walk (HP:0002540)1.67770378
94Specific learning disability (HP:0001328)1.67698962
95Abnormality of glycine metabolism (HP:0010895)1.67519578
96Abnormality of serine family amino acid metabolism (HP:0010894)1.67519578
97Renal hypoplasia (HP:0000089)1.67465603
98Broad foot (HP:0001769)1.66873751
99Abnormality of the pons (HP:0007361)1.66171378
100Hypoplasia of the pons (HP:0012110)1.66027682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK32.82986682
2CASK2.77253105
3ZAK2.62712665
4TNIK2.51079484
5NUAK12.42504994
6TRIM282.40609180
7VRK22.32161092
8DYRK22.28539506
9CDC72.20956811
10MKNK22.17629007
11MAP3K42.13377448
12MAP4K22.09294335
13MKNK12.04537032
14BMPR1B2.02370605
15FRK1.92132425
16MARK11.92090939
17BUB11.88034194
18BCR1.86792939
19VRK11.85018340
20TAF11.84982324
21SRPK11.82877158
22DYRK31.80614049
23PLK41.76309942
24PLK31.66177880
25MAPK131.56476728
26WEE11.55665027
27CDK191.55607809
28PASK1.52968045
29ADRBK21.50863579
30MAP2K71.45321588
31BRSK21.39540648
32TTK1.38858659
33PINK11.36222141
34GRK11.35862660
35PNCK1.33287565
36ACVR1B1.28439056
37EPHA41.27697265
38STK161.23969394
39CSNK1G11.22895352
40CSNK1G21.15260639
41INSRR1.11330889
42PLK11.08437213
43CSNK1G31.07414010
44TLK11.04677737
45PLK21.02870377
46NEK21.01079680
47OXSR10.98376871
48PRKCG0.96711906
49TGFBR10.91621197
50CSNK1A1L0.90302660
51PAK30.89935061
52MINK10.89530308
53TSSK60.89186533
54NME10.88959102
55EPHB20.87772636
56BCKDK0.87123384
57NEK10.81579666
58CHEK20.80814429
59ATR0.80197198
60ERBB30.80028677
61RPS6KA40.79727680
62WNK40.77305557
63DYRK1A0.71691269
64STK38L0.71655962
65FGFR20.71449203
66PBK0.67906556
67UHMK10.66965776
68PRKCE0.62832327
69NTRK20.61146750
70STK30.60114594
71AURKB0.54830510
72ATM0.53550200
73TIE10.50418602
74PKN10.46952908
75CSNK1A10.45800594
76CDK30.45081944
77CSNK1E0.45043551
78BRSK10.44174796
79STK110.43450042
80RPS6KA50.42622185
81EIF2AK30.41833256
82MAP2K40.40714948
83NLK0.39752204
84CAMK2A0.39332898
85LATS10.38896429
86DAPK20.38695330
87ADRBK10.38606488
88SGK4940.37976488
89SGK2230.37976488
90CSNK2A10.37576218
91CSNK1D0.35739884
92PRKACA0.34698004
93STK390.33170090
94CHEK10.32822843
95TYRO30.32600148
96CDK10.31541000
97FGFR10.31432353
98AKT30.30949365
99AURKA0.30679439
100MAPKAPK50.30234938

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.12230078
2Parkinsons disease_Homo sapiens_hsa050122.78349530
3Ribosome_Homo sapiens_hsa030102.74476598
4Protein export_Homo sapiens_hsa030602.71764550
5Homologous recombination_Homo sapiens_hsa034402.55850344
6Mismatch repair_Homo sapiens_hsa034302.53370154
7RNA polymerase_Homo sapiens_hsa030202.50439073
8Fanconi anemia pathway_Homo sapiens_hsa034602.33834674
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30859472
10Basal transcription factors_Homo sapiens_hsa030222.13604883
11Huntingtons disease_Homo sapiens_hsa050162.08978683
12Nicotine addiction_Homo sapiens_hsa050332.01040608
13RNA degradation_Homo sapiens_hsa030181.98077249
14DNA replication_Homo sapiens_hsa030301.94088174
15Non-homologous end-joining_Homo sapiens_hsa034501.90942268
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87224478
17Phototransduction_Homo sapiens_hsa047441.84296803
18Proteasome_Homo sapiens_hsa030501.77121861
19Spliceosome_Homo sapiens_hsa030401.73415017
20Alzheimers disease_Homo sapiens_hsa050101.65525261
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64155373
22Propanoate metabolism_Homo sapiens_hsa006401.58207357
23Steroid biosynthesis_Homo sapiens_hsa001001.57556997
24Cardiac muscle contraction_Homo sapiens_hsa042601.55296834
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54939326
26RNA transport_Homo sapiens_hsa030131.54170706
27Base excision repair_Homo sapiens_hsa034101.52415203
28Selenocompound metabolism_Homo sapiens_hsa004501.49243839
29Butanoate metabolism_Homo sapiens_hsa006501.45539692
30Nucleotide excision repair_Homo sapiens_hsa034201.41137705
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39500608
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32319924
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32156282
34Basal cell carcinoma_Homo sapiens_hsa052171.28085705
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23271354
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21526316
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20939308
38Cell cycle_Homo sapiens_hsa041101.20178294
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16518008
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.15614669
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14110723
42Hedgehog signaling pathway_Homo sapiens_hsa043401.12499789
43One carbon pool by folate_Homo sapiens_hsa006701.10097941
44Pyrimidine metabolism_Homo sapiens_hsa002401.05364849
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.04984516
46Taste transduction_Homo sapiens_hsa047421.04874403
47Linoleic acid metabolism_Homo sapiens_hsa005911.03992271
48Purine metabolism_Homo sapiens_hsa002301.01281708
49Nitrogen metabolism_Homo sapiens_hsa009101.00570000
50Fatty acid elongation_Homo sapiens_hsa000620.97241758
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96056825
52Ether lipid metabolism_Homo sapiens_hsa005650.95181434
53Caffeine metabolism_Homo sapiens_hsa002320.90986366
54Tryptophan metabolism_Homo sapiens_hsa003800.90253319
55Peroxisome_Homo sapiens_hsa041460.89747990
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86524075
57GABAergic synapse_Homo sapiens_hsa047270.84545563
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80327074
59Olfactory transduction_Homo sapiens_hsa047400.79979741
60Morphine addiction_Homo sapiens_hsa050320.79767203
61mRNA surveillance pathway_Homo sapiens_hsa030150.79375524
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78878225
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78572711
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75888185
65Oocyte meiosis_Homo sapiens_hsa041140.74299448
66Pyruvate metabolism_Homo sapiens_hsa006200.73729913
67Hippo signaling pathway_Homo sapiens_hsa043900.70350475
68Metabolic pathways_Homo sapiens_hsa011000.69924252
69Regulation of autophagy_Homo sapiens_hsa041400.69808953
70Glutamatergic synapse_Homo sapiens_hsa047240.68039335
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66497390
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65855313
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.64576925
74Serotonergic synapse_Homo sapiens_hsa047260.63385298
75Retinol metabolism_Homo sapiens_hsa008300.62900467
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62507884
77Axon guidance_Homo sapiens_hsa043600.60738198
78Vitamin digestion and absorption_Homo sapiens_hsa049770.59408711
79Wnt signaling pathway_Homo sapiens_hsa043100.55141235
80Circadian entrainment_Homo sapiens_hsa047130.54542402
81Collecting duct acid secretion_Homo sapiens_hsa049660.50444441
82Dopaminergic synapse_Homo sapiens_hsa047280.50152266
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50070802
84Folate biosynthesis_Homo sapiens_hsa007900.49987678
85p53 signaling pathway_Homo sapiens_hsa041150.49517611
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.49141967
87Cocaine addiction_Homo sapiens_hsa050300.48511942
88Chemical carcinogenesis_Homo sapiens_hsa052040.46656253
89Alcoholism_Homo sapiens_hsa050340.45487656
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44576509
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40708041
92beta-Alanine metabolism_Homo sapiens_hsa004100.39500989
93TGF-beta signaling pathway_Homo sapiens_hsa043500.38452753
94Arginine and proline metabolism_Homo sapiens_hsa003300.38337994
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37238877
96Glutathione metabolism_Homo sapiens_hsa004800.36638422
97Long-term depression_Homo sapiens_hsa047300.36174737
98Insulin secretion_Homo sapiens_hsa049110.35501259
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34409703
100Lysine degradation_Homo sapiens_hsa003100.31644178

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