ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.06475661
2	DNA replication checkpoint (GO:0000076)	3.48089354
3	presynaptic membrane organization (GO:0097090)	3.31476068
4	replication fork processing (GO:0031297)	3.28775852
5	DNA damage response, detection of DNA damage (GO:0042769)	3.26632179
6	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.23053730
7	regulation of mitotic spindle checkpoint (GO:1903504)	3.19179233
8	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.19179233
9	nucleobase catabolic process (GO:0046113)	3.15291503
10	presynaptic membrane assembly (GO:0097105)	3.02610608
11	DNA double-strand break processing (GO:0000729)	2.98708833
12	behavioral response to nicotine (GO:0035095)	2.98658849
13	establishment of mitochondrion localization (GO:0051654)	2.98150394
14	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.94455016
15	spinal cord development (GO:0021510)	2.87516555
16	negative regulation of telomere maintenance (GO:0032205)	2.82483166
17	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.79998375
18	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.79998375
19	neural tube formation (GO:0001841)	2.79756429
20	resolution of meiotic recombination intermediates (GO:0000712)	2.79431320
21	maturation of SSU-rRNA (GO:0030490)	2.75470962
22	nonmotile primary cilium assembly (GO:0035058)	2.73865640
23	peptidyl-histidine modification (GO:0018202)	2.73717570
24	pseudouridine synthesis (GO:0001522)	2.69856039
25	regulation of posttranscriptional gene silencing (GO:0060147)	2.64360020
26	regulation of gene silencing by miRNA (GO:0060964)	2.64360020
27	regulation of gene silencing by RNA (GO:0060966)	2.64360020
28	mitochondrion transport along microtubule (GO:0047497)	2.60752554
29	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.60752554
30	chromatin remodeling at centromere (GO:0031055)	2.56120070
31	ribosomal small subunit assembly (GO:0000028)	2.53078811
32	regulation of development, heterochronic (GO:0040034)	2.51675619
33	translesion synthesis (GO:0019985)	2.51399111
34	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.50965081
35	L-serine metabolic process (GO:0006563)	2.50064115
36	neuron cell-cell adhesion (GO:0007158)	2.49941484
37	somite development (GO:0061053)	2.45839509
38	tongue development (GO:0043586)	2.45077281
39	axonal fasciculation (GO:0007413)	2.44322757
40	regulation of telomere maintenance (GO:0032204)	2.43180455
41	postsynaptic membrane organization (GO:0001941)	2.41325729
42	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.39779044
43	mitochondrial respiratory chain complex assembly (GO:0033108)	2.39606493
44	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.39110195
45	regulation of translation, ncRNA-mediated (GO:0045974)	2.39110195
46	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.39110195
47	protein polyglutamylation (GO:0018095)	2.38797122
48	DNA replication-dependent nucleosome assembly (GO:0006335)	2.37476611
49	DNA replication-dependent nucleosome organization (GO:0034723)	2.37476611
50	DNA topological change (GO:0006265)	2.37306288
51	forebrain neuron differentiation (GO:0021879)	2.36596681
52	hindbrain development (GO:0030902)	2.35235035
53	neuron recognition (GO:0008038)	2.34462180
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.34286394
55	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.34286394
56	NADH dehydrogenase complex assembly (GO:0010257)	2.34286394
57	pre-miRNA processing (GO:0031054)	2.33725590
58	protein complex biogenesis (GO:0070271)	2.33044842
59	limb bud formation (GO:0060174)	2.31809269
60	mitochondrial RNA metabolic process (GO:0000959)	2.31791347
61	histone H2A acetylation (GO:0043968)	2.31190423
62	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.31116814
63	regulation of timing of cell differentiation (GO:0048505)	2.30524807
64	retinal ganglion cell axon guidance (GO:0031290)	2.30337640
65	neurotransmitter-gated ion channel clustering (GO:0072578)	2.30114520
66	negative regulation of mRNA processing (GO:0050686)	2.29844386
67	negative regulation of RNA splicing (GO:0033119)	2.28453420
68	cell proliferation in forebrain (GO:0021846)	2.27165997
69	head development (GO:0060322)	2.26865123
70	microtubule depolymerization (GO:0007019)	2.25895322
71	chromatin assembly (GO:0031497)	2.23909603
72	intraciliary transport (GO:0042073)	2.22387425
73	nucleosome disassembly (GO:0006337)	2.22207295
74	protein-DNA complex disassembly (GO:0032986)	2.22207295
75	kidney morphogenesis (GO:0060993)	2.22145304
76	recombinational repair (GO:0000725)	2.21273892
77	cell migration in hindbrain (GO:0021535)	2.19853913
78	heterochromatin organization (GO:0070828)	2.19311546
79	kinetochore assembly (GO:0051382)	2.18926966
80	behavioral response to ethanol (GO:0048149)	2.18364340
81	ubiquinone metabolic process (GO:0006743)	2.18144816
82	DNA strand elongation involved in DNA replication (GO:0006271)	2.17949314
83	nucleobase biosynthetic process (GO:0046112)	2.17919188
84	protein-cofactor linkage (GO:0018065)	2.17648624
85	translational termination (GO:0006415)	2.17228496
86	CENP-A containing nucleosome assembly (GO:0034080)	2.16975826
87	double-strand break repair via homologous recombination (GO:0000724)	2.16583225
88	pituitary gland development (GO:0021983)	2.15767684
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.15291587
90	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.15291587
91	cell differentiation in spinal cord (GO:0021515)	2.14553632
92	reciprocal meiotic recombination (GO:0007131)	2.13461118
93	reciprocal DNA recombination (GO:0035825)	2.13461118
94	viral transcription (GO:0019083)	2.12535314
95	regulation of telomere maintenance via telomerase (GO:0032210)	2.11412475
96	protein localization to synapse (GO:0035418)	2.11334287
97	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.09826558
98	centriole replication (GO:0007099)	2.08918561
99	neuronal stem cell maintenance (GO:0097150)	2.08626896
100	mRNA splice site selection (GO:0006376)	2.08392056

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.35472206
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.80206230
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.51329521
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.97675403
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.94667555
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.72912049
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.70142374
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56336754
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.49184904
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.42133579
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40506240
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.33820644
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.32472645
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.27249084
15	* ETS1_20019798_ChIP-Seq_JURKAT_Human	2.14861599
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.09049021
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.08346098
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.07962162
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.99601254
20	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.91162602
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.86472474
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.86124297
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.82730892
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.79162513
25	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.71775039
26	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.69573828
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.69175545
28	XRN2_22483619_ChIP-Seq_HELA_Human	1.67708261
29	VDR_22108803_ChIP-Seq_LS180_Human	1.67223239
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.65823316
31	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.65562039
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61177723
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.60413579
34	* EWS_26573619_Chip-Seq_HEK293_Human	1.59715570
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.58910209
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.58158199
37	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.57711622
38	FUS_26573619_Chip-Seq_HEK293_Human	1.57219362
39	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.51908734
40	* GABP_19822575_ChIP-Seq_HepG2_Human	1.47428033
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.46544111
42	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.44935467
43	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.43771006
44	GBX2_23144817_ChIP-Seq_PC3_Human	1.41800023
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41297243
46	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.38770010
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.36774577
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35114844
49	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.34683445
50	VDR_23849224_ChIP-Seq_CD4+_Human	1.34488012
51	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.34203217
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32760799
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32538070
54	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.29108042
55	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28146811
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27943489
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27185255
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.25439183
59	KDM5A_27292631_Chip-Seq_BREAST_Human	1.25383118
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25296320
61	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24820443
62	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22040633
63	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.16458385
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10144221
65	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09472139
66	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.08756913
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08584121
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07902569
69	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.07208724
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.06504939
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05975840
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05360443
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.05360443
74	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.04213263
75	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.03974142
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.03586146
77	P300_19829295_ChIP-Seq_ESCs_Human	1.02544080
78	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.02517953
79	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00218283
80	TAF15_26573619_Chip-Seq_HEK293_Human	0.99141979
81	TP53_22573176_ChIP-Seq_HFKS_Human	0.99050688
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99042804
83	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.98809730
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98679294
85	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.98637273
86	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.98347602
87	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.95192211
88	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.94853251
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94278778
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91829793
91	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.90817568
92	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.89694001
93	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88897015
94	SOX9_26525672_Chip-Seq_HEART_Mouse	0.88823313
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.88752497
96	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.86644566
97	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.86297758
98	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.85778543
99	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.85391751
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.85181369

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.22968597
2	MP0008877_abnormal_DNA_methylation	2.45520089
3	MP0003122_maternal_imprinting	2.28186474
4	MP0003136_yellow_coat_color	2.26833617
5	MP0003121_genomic_imprinting	2.16873856
6	MP0000778_abnormal_nervous_system	2.11081002
7	MP0003880_abnormal_central_pattern	2.09803417
8	MP0002736_abnormal_nociception_after	2.08473554
9	MP0008058_abnormal_DNA_repair	2.03799118
10	MP0001529_abnormal_vocalization	2.02181078
11	MP0003787_abnormal_imprinting	1.94345687
12	MP0002938_white_spotting	1.94113801
13	MP0000566_synostosis	1.93796038
14	MP0003890_abnormal_embryonic-extraembry	1.89744057
15	MP0002653_abnormal_ependyma_morphology	1.88182803
16	MP0003693_abnormal_embryo_hatching	1.86538391
17	MP0001968_abnormal_touch/_nociception	1.80812168
18	MP0001293_anophthalmia	1.80201512
19	MP0000631_abnormal_neuroendocrine_gland	1.77120351
20	MP0004133_heterotaxia	1.71874110
21	MP0000049_abnormal_middle_ear	1.69839044
22	MP0006276_abnormal_autonomic_nervous	1.69607153
23	MP0005499_abnormal_olfactory_system	1.63015997
24	MP0005394_taste/olfaction_phenotype	1.63015997
25	MP0008789_abnormal_olfactory_epithelium	1.62196454
26	MP0010094_abnormal_chromosome_stability	1.59223199
27	MP0008995_early_reproductive_senescence	1.58450453
28	MP0003937_abnormal_limbs/digits/tail_de	1.57118147
29	MP0010030_abnormal_orbit_morphology	1.55875258
30	MP0004859_abnormal_synaptic_plasticity	1.55452397
31	MP0003567_abnormal_fetal_cardiomyocyte	1.49323279
32	MP0003111_abnormal_nucleus_morphology	1.48983274
33	MP0002249_abnormal_larynx_morphology	1.48695753
34	MP0002735_abnormal_chemical_nociception	1.47469627
35	MP0000955_abnormal_spinal_cord	1.40474367
36	MP0002102_abnormal_ear_morphology	1.37293616
37	MP0003861_abnormal_nervous_system	1.36782199
38	MP0003119_abnormal_digestive_system	1.35421013
39	MP0003938_abnormal_ear_development	1.33099540
40	MP0008932_abnormal_embryonic_tissue	1.33042318
41	MP0001188_hyperpigmentation	1.30628842
42	MP0002751_abnormal_autonomic_nervous	1.29683227
43	MP0006072_abnormal_retinal_apoptosis	1.26393403
44	MP0003123_paternal_imprinting	1.26344746
45	MP0002822_catalepsy	1.26159266
46	MP0003718_maternal_effect	1.24511969
47	MP0002184_abnormal_innervation	1.22458582
48	MP0001984_abnormal_olfaction	1.21238855
49	MP0003635_abnormal_synaptic_transmissio	1.20414002
50	MP0002638_abnormal_pupillary_reflex	1.19338180
51	MP0002233_abnormal_nose_morphology	1.17102656
52	MP0002697_abnormal_eye_size	1.17012724
53	MP0005645_abnormal_hypothalamus_physiol	1.14989932
54	MP0005551_abnormal_eye_electrophysiolog	1.14283148
55	MP0005423_abnormal_somatic_nervous	1.13410335
56	MP0002234_abnormal_pharynx_morphology	1.13220679
57	MP0004142_abnormal_muscle_tone	1.11631206
58	MP0001286_abnormal_eye_development	1.11579233
59	MP0002152_abnormal_brain_morphology	1.09354831
60	MP0002272_abnormal_nervous_system	1.09135088
61	MP0002557_abnormal_social/conspecific_i	1.08901955
62	MP0003077_abnormal_cell_cycle	1.07297544
63	MP0002752_abnormal_somatic_nervous	1.06903888
64	MP0002063_abnormal_learning/memory/cond	1.06671098
65	MP0005646_abnormal_pituitary_gland	1.06154440
66	MP0004147_increased_porphyrin_level	1.05876909
67	MP0003942_abnormal_urinary_system	1.05777657
68	MP0004957_abnormal_blastocyst_morpholog	1.05004406
69	MP0009697_abnormal_copulation	1.04081428
70	MP0002882_abnormal_neuron_morphology	1.03354722
71	MP0003385_abnormal_body_wall	1.01862687
72	MP0002084_abnormal_developmental_patter	1.01377848
73	MP0009745_abnormal_behavioral_response	1.00080969
74	MP0002572_abnormal_emotion/affect_behav	0.99427694
75	MP0002210_abnormal_sex_determination	0.98474258
76	MP0005253_abnormal_eye_physiology	0.98444594
77	MP0004811_abnormal_neuron_physiology	0.97248282
78	MP0009046_muscle_twitch	0.96965384
79	MP0003283_abnormal_digestive_organ	0.96926628
80	MP0003755_abnormal_palate_morphology	0.95234121
81	MP0000537_abnormal_urethra_morphology	0.93365933
82	MP0002734_abnormal_mechanical_nocicepti	0.93198069
83	MP0001485_abnormal_pinna_reflex	0.93126067
84	MP0001486_abnormal_startle_reflex	0.92865919
85	MP0002111_abnormal_tail_morphology	0.92102439
86	MP0008057_abnormal_DNA_replication	0.91436569
87	MP0005391_vision/eye_phenotype	0.91168942
88	MP0002085_abnormal_embryonic_tissue	0.90870078
89	MP0002282_abnormal_trachea_morphology	0.90718384
90	MP0003698_abnormal_male_reproductive	0.88933747
91	MP0004885_abnormal_endolymph	0.88255752
92	MP0006035_abnormal_mitochondrial_morpho	0.87417132
93	MP0001929_abnormal_gametogenesis	0.86603442
94	MP0005195_abnormal_posterior_eye	0.85704155
95	MP0003935_abnormal_craniofacial_develop	0.85091397
96	MP0002067_abnormal_sensory_capabilities	0.85024115
97	MP0001145_abnormal_male_reproductive	0.82534504
98	MP0003315_abnormal_perineum_morphology	0.81893675
99	MP0004145_abnormal_muscle_electrophysio	0.81048857
100	MP0009379_abnormal_foot_pigmentation	0.80588557

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.13389469
2	Reticulocytopenia (HP:0001896)	2.99080011
3	Pancreatic fibrosis (HP:0100732)	2.72800775
4	True hermaphroditism (HP:0010459)	2.69965147
5	Septo-optic dysplasia (HP:0100842)	2.65586583
6	Pancreatic cysts (HP:0001737)	2.65007389
7	Abnormality of cells of the erythroid lineage (HP:0012130)	2.63324309
8	Cortical dysplasia (HP:0002539)	2.62399959
9	Abnormal number of erythroid precursors (HP:0012131)	2.56506569
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.53175067
11	Nephronophthisis (HP:0000090)	2.52633063
12	Pendular nystagmus (HP:0012043)	2.51673593
13	Rib fusion (HP:0000902)	2.49843224
14	Chromsome breakage (HP:0040012)	2.42106807
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.41936152
16	Patellar aplasia (HP:0006443)	2.38065391
17	Colon cancer (HP:0003003)	2.37527817
18	Gait imbalance (HP:0002141)	2.34859136
19	Sclerocornea (HP:0000647)	2.31975197
20	Abnormality of midbrain morphology (HP:0002418)	2.29301325
21	Molar tooth sign on MRI (HP:0002419)	2.29301325
22	Meckel diverticulum (HP:0002245)	2.29105698
23	Medial flaring of the eyebrow (HP:0010747)	2.26875177
24	Abnormality of the ileum (HP:0001549)	2.25751919
25	Lissencephaly (HP:0001339)	2.24479373
26	Aplasia/Hypoplasia of the patella (HP:0006498)	2.19000728
27	Abnormality of the aortic arch (HP:0012303)	2.15155222
28	Birth length less than 3rd percentile (HP:0003561)	2.14436969
29	Anencephaly (HP:0002323)	2.11550283
30	Congenital primary aphakia (HP:0007707)	2.11462252
31	Retinal dysplasia (HP:0007973)	2.10880708
32	Nephrogenic diabetes insipidus (HP:0009806)	2.04968645
33	Hyperglycinemia (HP:0002154)	2.03916595
34	Ectopic kidney (HP:0000086)	2.00070714
35	Supernumerary spleens (HP:0009799)	2.00062639
36	Triphalangeal thumb (HP:0001199)	1.98878976
37	High anterior hairline (HP:0009890)	1.98714972
38	Abnormality of the carotid arteries (HP:0005344)	1.98060138
39	Abnormality of the renal medulla (HP:0100957)	1.96725705
40	Abnormality of the diencephalon (HP:0010662)	1.96439901
41	Preaxial hand polydactyly (HP:0001177)	1.94840093
42	Pachygyria (HP:0001302)	1.91560718
43	Anophthalmia (HP:0000528)	1.91433277
44	Vaginal atresia (HP:0000148)	1.87139948
45	Genital tract atresia (HP:0001827)	1.86818716
46	Abnormal lung lobation (HP:0002101)	1.85280343
47	Postaxial foot polydactyly (HP:0001830)	1.85204158
48	Renal hypoplasia (HP:0000089)	1.84155556
49	Optic nerve hypoplasia (HP:0000609)	1.83090576
50	Absent thumb (HP:0009777)	1.81277166
51	Congenital stationary night blindness (HP:0007642)	1.80950936
52	Absent septum pellucidum (HP:0001331)	1.80770075
53	Microvesicular hepatic steatosis (HP:0001414)	1.80747182
54	Acute necrotizing encephalopathy (HP:0006965)	1.80532462
55	Poor coordination (HP:0002370)	1.80344233
56	Limb dystonia (HP:0002451)	1.77503001
57	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77003164
58	Acute encephalopathy (HP:0006846)	1.76323812
59	Horseshoe kidney (HP:0000085)	1.75897466
60	Aganglionic megacolon (HP:0002251)	1.75258802
61	Cystic liver disease (HP:0006706)	1.75065271
62	Esophageal atresia (HP:0002032)	1.74342495
63	Oligodactyly (HP:0012165)	1.73739608
64	Abnormality of the preputium (HP:0100587)	1.73657602
65	Tubulointerstitial nephritis (HP:0001970)	1.73643865
66	Drooling (HP:0002307)	1.72568002
67	Ependymoma (HP:0002888)	1.72053988
68	Micropenis (HP:0000054)	1.71166683
69	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.70906234
70	Specific learning disability (HP:0001328)	1.70575901
71	Optic nerve coloboma (HP:0000588)	1.69727904
72	Broad-based gait (HP:0002136)	1.69175984
73	Postaxial hand polydactyly (HP:0001162)	1.68148064
74	Abnormality of DNA repair (HP:0003254)	1.67436807
75	Sloping forehead (HP:0000340)	1.67124650
76	Male pseudohermaphroditism (HP:0000037)	1.65549441
77	Abnormal mitochondria in muscle tissue (HP:0008316)	1.64996409
78	Polymicrogyria (HP:0002126)	1.63936637
79	Poor suck (HP:0002033)	1.62688433
80	Narrow forehead (HP:0000341)	1.62551773
81	Abnormality of chromosome stability (HP:0003220)	1.61376442
82	Holoprosencephaly (HP:0001360)	1.61341902
83	Multicystic kidney dysplasia (HP:0000003)	1.61064514
84	Abnormal number of incisors (HP:0011064)	1.60965557
85	Bilateral microphthalmos (HP:0007633)	1.60955525
86	Intestinal atresia (HP:0011100)	1.60952299
87	Gastrointestinal atresia (HP:0002589)	1.60675564
88	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.60189423
89	Oligodactyly (hands) (HP:0001180)	1.59554313
90	Dandy-Walker malformation (HP:0001305)	1.59365474
91	Type II lissencephaly (HP:0007260)	1.58032555
92	Hemivertebrae (HP:0002937)	1.57034938
93	Impulsivity (HP:0100710)	1.56942239
94	Morphological abnormality of the inner ear (HP:0011390)	1.55597712
95	Myelomeningocele (HP:0002475)	1.55314812
96	Decreased testicular size (HP:0008734)	1.54963094
97	Elfin facies (HP:0004428)	1.54705290
98	Abnormality of the septum pellucidum (HP:0007375)	1.54296501
99	Scrotal hypoplasia (HP:0000046)	1.53880509
100	Abnormal biliary tract physiology (HP:0012439)	1.53654124

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	2.96912561
2	TRIM28	2.70059089
3	ZAK	2.64606860
4	WNK3	2.64020707
5	DYRK2	2.62564649
6	CDC7	2.52079301
7	TNIK	2.47856507
8	MAP3K4	2.34657354
9	CASK	2.32291221
10	PLK4	2.25876568
11	TSSK6	2.19104280
12	NUAK1	2.08141322
13	SRPK1	2.00785711
14	MAP4K2	2.00206593
15	MAPK13	1.96506848
16	INSRR	1.89738926
17	MAP2K7	1.83231495
18	MKNK2	1.81767753
19	MKNK1	1.78001531
20	BCKDK	1.74569570
21	PNCK	1.72615797
22	WNK4	1.68401234
23	TTK	1.65790990
24	BMPR1B	1.65754054
25	BUB1	1.53914035
26	CDK19	1.47120730
27	WEE1	1.42929685
28	NTRK2	1.40704290
29	VRK2	1.37131847
30	PINK1	1.35972108
31	CHEK2	1.33828955
32	PLK3	1.17879090
33	BCR	1.16222993
34	MAP3K10	1.15506313
35	GRK1	1.13884663
36	DYRK3	1.13325958
37	ATR	1.11581478
38	EPHA4	1.11324697
39	PLK1	1.10961745
40	VRK1	1.10178137
41	NEK2	1.07854768
42	PASK	1.06402830
43	NTRK3	1.06204031
44	MINK1	1.05966078
45	PRKCG	0.98877673
46	TYRO3	0.97847068
47	CCNB1	0.97650010
48	CSNK1G2	0.96380418
49	TLK1	0.90926335
50	NME1	0.90062619
51	CSNK1G1	0.88850338
52	CSNK1G3	0.88038336
53	MAP2K4	0.86761835
54	ADRBK2	0.83406116
55	FGFR2	0.83252054
56	EEF2K	0.82562439
57	ATM	0.81224655
58	TAF1	0.80726465
59	FRK	0.79001707
60	CSNK1A1L	0.74743967
61	CSNK1E	0.74055898
62	TGFBR1	0.70543557
63	CHEK1	0.68032035
64	AURKA	0.67567022
65	PRKD3	0.62852273
66	CDK1	0.59679522
67	SIK2	0.59371496
68	AURKB	0.59039402
69	CDK2	0.58909296
70	STK39	0.57535424
71	CDK8	0.57404330
72	CAMK1G	0.56697540
73	DYRK1A	0.54249072
74	PRKDC	0.53607169
75	OXSR1	0.52648153
76	UHMK1	0.51299805
77	LATS1	0.50218156
78	CAMK1D	0.49895784
79	PAK3	0.48425690
80	PKN1	0.48015778
81	PLK2	0.46373285
82	BRSK1	0.45754420
83	PRKCZ	0.44357569
84	BRSK2	0.44080769
85	PRKCE	0.43305577
86	CSNK2A2	0.42933460
87	PRKCI	0.41341228
88	CDK7	0.40611238
89	EPHB2	0.40482593
90	CSNK1A1	0.40391524
91	KSR1	0.39438541
92	RPS6KA4	0.39403276
93	RPS6KA5	0.38688337
94	IRAK1	0.37686186
95	MAPK15	0.37325954
96	CDK18	0.36986445
97	CDK11A	0.36907187
98	PRKAA1	0.36112415
99	GSK3B	0.36088118
100	CDK15	0.35682257

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	2.74058580
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.55951399
3	Ribosome_Homo sapiens_hsa03010	2.49942082
4	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.30423784
5	Base excision repair_Homo sapiens_hsa03410	2.15712273
6	DNA replication_Homo sapiens_hsa03030	2.14655719
7	Spliceosome_Homo sapiens_hsa03040	2.14318556
8	Nicotine addiction_Homo sapiens_hsa05033	2.08898902
9	RNA polymerase_Homo sapiens_hsa03020	2.06748675
10	Parkinsons disease_Homo sapiens_hsa05012	1.96203005
11	Mismatch repair_Homo sapiens_hsa03430	1.96008062
12	Steroid biosynthesis_Homo sapiens_hsa00100	1.95418718
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.94917509
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91179891
15	Basal transcription factors_Homo sapiens_hsa03022	1.88025771
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.86182066
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.85024473
18	RNA transport_Homo sapiens_hsa03013	1.81131480
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.79157094
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73574949
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.73031589
22	RNA degradation_Homo sapiens_hsa03018	1.67355176
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.66197764
24	One carbon pool by folate_Homo sapiens_hsa00670	1.63270165
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58426956
26	Sulfur relay system_Homo sapiens_hsa04122	1.57490953
27	Butanoate metabolism_Homo sapiens_hsa00650	1.52298466
28	Phototransduction_Homo sapiens_hsa04744	1.48196307
29	Huntingtons disease_Homo sapiens_hsa05016	1.48166366
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.47705749
31	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.45030519
32	Protein export_Homo sapiens_hsa03060	1.43207993
33	Basal cell carcinoma_Homo sapiens_hsa05217	1.31252724
34	Cell cycle_Homo sapiens_hsa04110	1.30732547
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29260197
36	Propanoate metabolism_Homo sapiens_hsa00640	1.24666948
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.23745325
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.19600097
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17842393
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14022260
41	mRNA surveillance pathway_Homo sapiens_hsa03015	1.12066897
42	Proteasome_Homo sapiens_hsa03050	1.03279486
43	Alzheimers disease_Homo sapiens_hsa05010	1.01217957
44	Axon guidance_Homo sapiens_hsa04360	1.00075388
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98682188
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98363511
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.97134271
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96605873
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95321214
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.93501516
51	Purine metabolism_Homo sapiens_hsa00230	0.93138710
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.91845819
53	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.90751755
54	Hippo signaling pathway_Homo sapiens_hsa04390	0.90654454
55	GABAergic synapse_Homo sapiens_hsa04727	0.90451690
56	Taste transduction_Homo sapiens_hsa04742	0.90179783
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.89334002
58	Olfactory transduction_Homo sapiens_hsa04740	0.87690257
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.82736093
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.82641393
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.82558783
62	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.80224508
63	Lysine degradation_Homo sapiens_hsa00310	0.77688756
64	Morphine addiction_Homo sapiens_hsa05032	0.77570243
65	Oocyte meiosis_Homo sapiens_hsa04114	0.77521479
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75304667
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.73951220
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.72235409
69	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.71550823
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.67135393
71	Wnt signaling pathway_Homo sapiens_hsa04310	0.66751948
72	Cocaine addiction_Homo sapiens_hsa05030	0.65822860
73	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.65460644
74	Nitrogen metabolism_Homo sapiens_hsa00910	0.65409218
75	Fatty acid elongation_Homo sapiens_hsa00062	0.65303636
76	Alcoholism_Homo sapiens_hsa05034	0.65206655
77	Metabolic pathways_Homo sapiens_hsa01100	0.64852215
78	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.63495979
79	Circadian entrainment_Homo sapiens_hsa04713	0.63397835
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62318579
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61603758
82	Long-term depression_Homo sapiens_hsa04730	0.50805613
83	Folate biosynthesis_Homo sapiens_hsa00790	0.49648755
84	Peroxisome_Homo sapiens_hsa04146	0.47552264
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46493603
86	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45121329
87	Insulin secretion_Homo sapiens_hsa04911	0.42488878
88	Cholinergic synapse_Homo sapiens_hsa04725	0.41559397
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38028411
90	Serotonergic synapse_Homo sapiens_hsa04726	0.37164965
91	p53 signaling pathway_Homo sapiens_hsa04115	0.35674138
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.33771411
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33665937
94	Amphetamine addiction_Homo sapiens_hsa05031	0.32783305
95	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31676723
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.31388238
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30503405
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.28574124
99	Melanogenesis_Homo sapiens_hsa04916	0.27811046
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27564213

ZNF74

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »