ZNF740

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.87352656
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.81294098
3antigen processing and presentation of endogenous antigen (GO:0019883)4.43551765
4negative regulation of erythrocyte differentiation (GO:0045647)4.33845943
5positive regulation of gamma-delta T cell activation (GO:0046645)4.33226977
6positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.28481657
7T cell migration (GO:0072678)4.17208311
8regulation of histone H3-K27 methylation (GO:0061085)3.87793162
9thymic T cell selection (GO:0045061)3.80052626
10positive thymic T cell selection (GO:0045059)3.77891986
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.74404592
12negative regulation of cell killing (GO:0031342)3.74404592
13mannose metabolic process (GO:0006013)3.63383650
14negative thymic T cell selection (GO:0045060)3.62095253
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54660365
16B cell receptor signaling pathway (GO:0050853)3.53705662
17histone H3-K36 demethylation (GO:0070544)3.51522511
18negative T cell selection (GO:0043383)3.50461284
19response to muramyl dipeptide (GO:0032495)3.46134518
20regulation of chromatin binding (GO:0035561)3.42591816
21antigen processing and presentation via MHC class Ib (GO:0002475)3.37561404
22T cell selection (GO:0045058)3.34620085
23regulation of B cell receptor signaling pathway (GO:0050855)3.34409762
24positive T cell selection (GO:0043368)3.32616362
25regulation of gamma-delta T cell activation (GO:0046643)3.23065144
26modulation by symbiont of host immune response (GO:0052553)3.15964911
27positive regulation by symbiont of host defense response (GO:0052509)3.15964911
28modulation by symbiont of host defense response (GO:0052031)3.15964911
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15964911
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15964911
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.15964911
32regulation of gamma-delta T cell differentiation (GO:0045586)3.13846088
33nuclear pore complex assembly (GO:0051292)3.13205133
34ribosomal small subunit biogenesis (GO:0042274)3.07180342
35leukocyte aggregation (GO:0070486)3.07093472
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04661161
37regulation of RNA export from nucleus (GO:0046831)3.04343910
38CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.03852958
39detection of other organism (GO:0098543)2.96567075
40regulation of glucose import in response to insulin stimulus (GO:2001273)2.95754447
41detection of bacterium (GO:0016045)2.95744811
42regulation of type I interferon-mediated signaling pathway (GO:0060338)2.95603560
433-UTR-mediated mRNA stabilization (GO:0070935)2.91980759
44RNA stabilization (GO:0043489)2.91001177
45mRNA stabilization (GO:0048255)2.91001177
46response to interleukin-15 (GO:0070672)2.90859203
47response to laminar fluid shear stress (GO:0034616)2.90168848
48embryonic process involved in female pregnancy (GO:0060136)2.82746529
49cellular response to virus (GO:0098586)2.81293032
50regulation of nucleobase-containing compound transport (GO:0032239)2.80281392
51B cell homeostasis (GO:0001782)2.77939939
52regulation of necroptotic process (GO:0060544)2.76719012
53negative regulation of toll-like receptor signaling pathway (GO:0034122)2.75930217
54negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.75881147
55germinal center formation (GO:0002467)2.75034949
56positive regulation of B cell differentiation (GO:0045579)2.73876982
57regulation of interferon-beta biosynthetic process (GO:0045357)2.72114833
58regulation of NFAT protein import into nucleus (GO:0051532)2.71927931
59modulation by virus of host process (GO:0019054)2.71079739
60activation of Rac GTPase activity (GO:0032863)2.68001752
61macrophage activation involved in immune response (GO:0002281)2.66962280
62regulation of B cell differentiation (GO:0045577)2.65550677
63mitotic chromosome condensation (GO:0007076)2.65473372
64lymphocyte migration (GO:0072676)2.63366092
65regulation of ARF protein signal transduction (GO:0032012)2.60893859
66modulation by symbiont of host cellular process (GO:0044068)2.60800234
67response to peptidoglycan (GO:0032494)2.56833321
68natural killer cell differentiation (GO:0001779)2.55502160
69detection of external biotic stimulus (GO:0098581)2.55418395
70Peyers patch development (GO:0048541)2.52097167
71mucosal-associated lymphoid tissue development (GO:0048537)2.52097167
72T cell lineage commitment (GO:0002360)2.50555777
73histone H3-K4 methylation (GO:0051568)2.48096579
74histone H3-K4 trimethylation (GO:0080182)2.47925669
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47846818
76negative regulation of necroptotic process (GO:0060546)2.44420523
77negative regulation of granulocyte differentiation (GO:0030853)2.44027675
78focal adhesion assembly (GO:0048041)2.41108360
79cell-substrate adherens junction assembly (GO:0007045)2.41108360
80detection of molecule of bacterial origin (GO:0032490)2.39285345
81positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.38408091
82G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.38164833
83apoptotic process involved in morphogenesis (GO:0060561)2.37887698
84nuclear pore organization (GO:0006999)2.34658636
85regulation of alpha-beta T cell proliferation (GO:0046640)2.34283844
86regulation of interleukin-2 biosynthetic process (GO:0045076)2.34030445
87histone lysine demethylation (GO:0070076)2.32498723
88maternal placenta development (GO:0001893)2.32416691
89activation of JUN kinase activity (GO:0007257)2.31671711
90viral transcription (GO:0019083)2.31527054
91negative regulation of myotube differentiation (GO:0010832)2.31199562
92positive regulation of histone deacetylation (GO:0031065)2.31144111
93hepatocyte apoptotic process (GO:0097284)2.29413034
94negative regulation of lymphocyte mediated immunity (GO:0002707)2.28905414
95cellular response to interleukin-15 (GO:0071350)2.28607047
96regulation of granulocyte differentiation (GO:0030852)2.28519001
97megakaryocyte development (GO:0035855)2.27684134
98T cell homeostasis (GO:0043029)2.27676379
99DNA duplex unwinding (GO:0032508)2.26279893
100negative regulation of leukocyte mediated immunity (GO:0002704)2.25111289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.39816041
2VDR_21846776_ChIP-Seq_THP-1_Human3.98799348
3E2F7_22180533_ChIP-Seq_HELA_Human3.66891306
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05574780
5TCF7_22412390_ChIP-Seq_EML_Mouse2.70826259
6KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.65938050
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64922954
8MAF_26560356_Chip-Seq_TH1_Human2.55154721
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50905694
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.46710071
11VDR_24763502_ChIP-Seq_THP-1_Human2.42654278
12KDM2B_26808549_Chip-Seq_DND41_Human2.38867792
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32694162
14LXR_22292898_ChIP-Seq_THP-1_Human2.30256151
15MAF_26560356_Chip-Seq_TH2_Human2.28234443
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.25635486
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.25435775
18UTX_26944678_Chip-Seq_JUKART_Human2.14047862
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12686091
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.02871023
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98209176
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94855004
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.93289232
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92937099
25RACK7_27058665_Chip-Seq_MCF-7_Human1.92463294
26KDM2B_26808549_Chip-Seq_JURKAT_Human1.83082495
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80871194
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80221848
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.73663669
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71150325
31MYB_26560356_Chip-Seq_TH1_Human1.65285219
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64342466
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60848550
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55811236
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53602493
36SCL_19346495_ChIP-Seq_HPC-7_Human1.52468680
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52049737
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51267383
39KDM2B_26808549_Chip-Seq_K562_Human1.49873978
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49052033
41NCOR1_26117541_ChIP-Seq_K562_Human1.48597401
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43086150
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42804249
44CIITA_25753668_ChIP-Seq_RAJI_Human1.42741587
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41420354
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41236283
47MYB_26560356_Chip-Seq_TH2_Human1.39546354
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39096320
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.38244374
50P68_20966046_ChIP-Seq_HELA_Human1.35522362
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31851296
52RUNX_20019798_ChIP-Seq_JUKART_Human1.29490578
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29446891
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28645053
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28104801
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27926720
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.27760248
58SPI1_23547873_ChIP-Seq_NB4_Human1.26866173
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26619475
60XRN2_22483619_ChIP-Seq_HELA_Human1.24954835
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23677843
62SMC4_20622854_ChIP-Seq_HELA_Human1.22869749
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22653200
64CREB1_26743006_Chip-Seq_LNCaP_Human1.22563777
65* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21186673
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16819955
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.16419706
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15949599
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15710928
70GATA1_22025678_ChIP-Seq_K562_Human1.14512699
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13197733
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12055836
73SPI1_23127762_ChIP-Seq_K562_Human1.11528144
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09913549
75CHD1_26751641_Chip-Seq_LNCaP_Human1.09450777
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09211493
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09155431
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07633500
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05143207
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.04003423
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03045447
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02650686
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02161650
84GATA1_19941826_ChIP-Seq_K562_Human1.01527131
85CLOCK_20551151_ChIP-Seq_293T_Human1.01292441
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01109847
87ATF3_27146783_Chip-Seq_COLON_Human1.01091074
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01076062
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00609553
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00442027
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00280373
92* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99489208
93IRF8_27001747_Chip-Seq_BMDM_Mouse0.98179299
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97880106
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.97270888
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97050996
97BCOR_27268052_Chip-Seq_Bcells_Human0.96868104
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.95626207
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95615384
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94945910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.31655855
2MP0003303_peritoneal_inflammation3.12849396
3MP0003763_abnormal_thymus_physiology3.09661107
4MP0000685_abnormal_immune_system3.05210166
5MP0005076_abnormal_cell_differentiation2.91151748
6MP0001835_abnormal_antigen_presentation2.86384131
7MP0003705_abnormal_hypodermis_morpholog2.84358814
8MP0002009_preneoplasia2.53650580
9MP0003436_decreased_susceptibility_to2.46495246
10MP0005451_abnormal_body_composition2.27423448
11MP0003300_gastrointestinal_ulcer2.23341752
12MP0008057_abnormal_DNA_replication2.20592939
13MP0005409_darkened_coat_color2.15157004
14MP0001800_abnormal_humoral_immune2.13561344
15MP0002166_altered_tumor_susceptibility2.06745136
16MP0004381_abnormal_hair_follicle2.03608875
17MP0001790_abnormal_immune_system2.00925418
18MP0005387_immune_system_phenotype2.00925418
19MP0004185_abnormal_adipocyte_glucose1.99694782
20MP0002398_abnormal_bone_marrow1.89880845
21MP0003091_abnormal_cell_migration1.79169797
22MP0000703_abnormal_thymus_morphology1.78838070
23MP0004808_abnormal_hematopoietic_stem1.77588920
24MP0002420_abnormal_adaptive_immunity1.75569029
25MP0001819_abnormal_immune_cell1.73691918
26MP0009333_abnormal_splenocyte_physiolog1.72216451
27MP0001873_stomach_inflammation1.71666885
28MP0005671_abnormal_response_to1.71010075
29MP0003453_abnormal_keratinocyte_physiol1.70708348
30MP0010234_abnormal_vibrissa_follicle1.70519144
31MP0003111_abnormal_nucleus_morphology1.68558781
32MP0002723_abnormal_immune_serum1.66661372
33MP0005000_abnormal_immune_tolerance1.66005216
34MP0008260_abnormal_autophagy1.63841877
35MP0002452_abnormal_antigen_presenting1.63207643
36MP0005025_abnormal_response_to1.62869005
37MP0004947_skin_inflammation1.60356521
38MP0010155_abnormal_intestine_physiology1.59863910
39MP0000716_abnormal_immune_system1.58955934
40MP0002933_joint_inflammation1.52597125
41MP0002722_abnormal_immune_system1.51571924
42MP0002419_abnormal_innate_immunity1.50148793
43MP0002405_respiratory_system_inflammati1.43697402
44MP0002429_abnormal_blood_cell1.42428813
45MP0004264_abnormal_extraembryonic_tissu1.42129968
46MP0000689_abnormal_spleen_morphology1.39022532
47MP0000858_altered_metastatic_potential1.37892634
48MP0010307_abnormal_tumor_latency1.27642238
49MP0000490_abnormal_crypts_of1.27094480
50MP0009278_abnormal_bone_marrow1.25116307
51MP0002877_abnormal_melanocyte_morpholog1.24383788
52MP0002006_tumorigenesis1.21586102
53MP0003077_abnormal_cell_cycle1.19731880
54MP0000350_abnormal_cell_proliferation1.16762965
55MP0005058_abnormal_lysosome_morphology1.16604785
56MP0003172_abnormal_lysosome_physiology1.12144465
57MP0005666_abnormal_adipose_tissue1.11255883
58MP0001348_abnormal_lacrimal_gland1.09272342
59MP0001849_ear_inflammation1.01578527
60MP0001845_abnormal_inflammatory_respons0.99198031
61MP0002019_abnormal_tumor_incidence0.98273836
62MP0003866_abnormal_defecation0.97843568
63MP0005171_absent_coat_pigmentation0.97033061
64MP0002086_abnormal_extraembryonic_tissu0.96777158
65MP0001661_extended_life_span0.96121621
66MP0003724_increased_susceptibility_to0.94738973
67MP0005310_abnormal_salivary_gland0.94476022
68MP0003566_abnormal_cell_adhesion0.93714059
69MP0002089_abnormal_postnatal_growth/wei0.93648716
70MP0002998_abnormal_bone_remodeling0.93256011
71MP0001986_abnormal_taste_sensitivity0.92577436
72MP0005621_abnormal_cell_physiology0.91992713
73MP0010094_abnormal_chromosome_stability0.91394094
74MP0003693_abnormal_embryo_hatching0.90649615
75MP0001730_embryonic_growth_arrest0.90554304
76MP0005174_abnormal_tail_pigmentation0.90427050
77MP0002796_impaired_skin_barrier0.88331844
78MP0004130_abnormal_muscle_cell0.84608753
79MP0010352_gastrointestinal_tract_polyps0.84371464
80MP0003984_embryonic_growth_retardation0.83661729
81MP0000733_abnormal_muscle_development0.82674447
82MP0005423_abnormal_somatic_nervous0.81308688
83MP0002088_abnormal_embryonic_growth/wei0.80356070
84MP0009672_abnormal_birth_weight0.80072746
85MP0003183_abnormal_peptide_metabolism0.78482104
86MP0003448_altered_tumor_morphology0.77752411
87MP0000313_abnormal_cell_death0.77251388
88MP0003828_pulmonary_edema0.76982497
89MP0001346_abnormal_lacrimal_gland0.76160329
90MP0005375_adipose_tissue_phenotype0.74538733
91MP0009931_abnormal_skin_appearance0.74530514
92MP0001851_eye_inflammation0.74409323
93MP0001533_abnormal_skeleton_physiology0.74323001
94MP0009785_altered_susceptibility_to0.72683444
95MP0005464_abnormal_platelet_physiology0.72355195
96MP0003656_abnormal_erythrocyte_physiolo0.71850648
97MP0005380_embryogenesis_phenotype0.70567714
98MP0001672_abnormal_embryogenesis/_devel0.70567714
99MP0003221_abnormal_cardiomyocyte_apopto0.70504149
100MP0004957_abnormal_blastocyst_morpholog0.70140263

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.36731406
2Eczematoid dermatitis (HP:0000976)3.56836884
3Colitis (HP:0002583)3.20145768
4Ulnar bowing (HP:0003031)2.80420215
5Thin bony cortex (HP:0002753)2.78360531
6Basal cell carcinoma (HP:0002671)2.76247601
7Recurrent abscess formation (HP:0002722)2.69359193
8Recurrent viral infections (HP:0004429)2.63813089
9Gastrointestinal inflammation (HP:0004386)2.60463606
10Cellulitis (HP:0100658)2.58740087
11Viral hepatitis (HP:0006562)2.57918905
12Recurrent bacterial skin infections (HP:0005406)2.54586276
13Meningitis (HP:0001287)2.52104485
14Subacute progressive viral hepatitis (HP:0006572)2.48162952
15Syringomyelia (HP:0003396)2.47070430
16Spinal cord lesions (HP:0100561)2.47070430
17Emphysema (HP:0002097)2.45597794
18Inflammation of the large intestine (HP:0002037)2.43442455
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.39082142
20Intestinal fistula (HP:0100819)2.37060634
21Hemorrhage of the eye (HP:0011885)2.35436907
22Gastrointestinal infarctions (HP:0005244)2.35392671
23Gastrointestinal stroma tumor (HP:0100723)2.34706348
24Annular pancreas (HP:0001734)2.29090974
25Recurrent fungal infections (HP:0002841)2.27818089
26Squamous cell carcinoma (HP:0002860)2.27536315
27Flat acetabular roof (HP:0003180)2.25430085
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24903028
29Asymmetry of the thorax (HP:0001555)2.24792958
30Ankyloglossia (HP:0010296)2.23531553
31Recurrent cutaneous fungal infections (HP:0011370)2.22143899
32Chronic mucocutaneous candidiasis (HP:0002728)2.22143899
33Mediastinal lymphadenopathy (HP:0100721)2.19719668
34Metaphyseal cupping (HP:0003021)2.19183030
35Broad face (HP:0000283)2.18864392
36Turricephaly (HP:0000262)2.14106939
37Recurrent bronchitis (HP:0002837)2.12458863
38Nasal polyposis (HP:0100582)2.10076781
39Abnormality of macrophages (HP:0004311)2.08816405
40Spontaneous hematomas (HP:0007420)2.07569136
41Progressive external ophthalmoplegia (HP:0000590)2.06757771
42Panhypogammaglobulinemia (HP:0003139)2.06344418
43Dislocated radial head (HP:0003083)2.03025526
44Sparse lateral eyebrow (HP:0005338)2.02331897
45Pustule (HP:0200039)2.01287744
46Gingivitis (HP:0000230)1.99376813
47Increased IgE level (HP:0003212)1.98305370
48Abnormality of the thoracic spine (HP:0100711)1.97631226
49IgM deficiency (HP:0002850)1.95595662
50Dysmetric saccades (HP:0000641)1.93633540
51Prominent nose (HP:0000448)1.93007273
52Abnormality of oral frenula (HP:0000190)1.89117668
53Recurrent skin infections (HP:0001581)1.87764609
54Slow saccadic eye movements (HP:0000514)1.87139524
55Agammaglobulinemia (HP:0004432)1.86781982
56Long eyelashes (HP:0000527)1.86556415
57Abnormality of the radial head (HP:0003995)1.86388361
58Abnormality of the distal phalanx of the thumb (HP:0009617)1.86257482
59Abnormality of cells of the lymphoid lineage (HP:0012140)1.83399192
60Hyperacusis (HP:0010780)1.82700162
61T lymphocytopenia (HP:0005403)1.82157584
62Obstructive sleep apnea (HP:0002870)1.80628486
63Lymphopenia (HP:0001888)1.79876462
64Facial hemangioma (HP:0000329)1.78513350
65Hypochromic anemia (HP:0001931)1.76009808
66Myositis (HP:0100614)1.73486971
67Poikiloderma (HP:0001029)1.72963699
68Vasculitis (HP:0002633)1.71766281
69Thin ribs (HP:0000883)1.71002231
70Deep philtrum (HP:0002002)1.70268788
71Cerebral aneurysm (HP:0004944)1.70222197
72Germ cell neoplasia (HP:0100728)1.70190887
73Deep palmar crease (HP:0006191)1.70173398
74Obstructive lung disease (HP:0006536)1.69958509
75Chronic obstructive pulmonary disease (HP:0006510)1.69958509
76Long palpebral fissure (HP:0000637)1.69079281
77Hepatitis (HP:0012115)1.68585282
78Thoracic kyphosis (HP:0002942)1.68333487
79Micronodular cirrhosis (HP:0001413)1.67647919
80Segmental peripheral demyelination/remyelination (HP:0003481)1.67380778
81Papilloma (HP:0012740)1.67316811
82Verrucae (HP:0200043)1.67316811
83Abnormality of the nasal mucosa (HP:0000433)1.66963187
84Abnormality of T cells (HP:0002843)1.66036948
85Lip pit (HP:0100267)1.65791239
86Recurrent gram-negative bacterial infections (HP:0005420)1.64535689
87Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64329571
88Malnutrition (HP:0004395)1.60830388
89Chronic otitis media (HP:0000389)1.60368811
90Osteomyelitis (HP:0002754)1.59005420
91Abnormality of small intestinal villus morphology (HP:0011472)1.58598788
92Villous atrophy (HP:0011473)1.58598788
93Orchitis (HP:0100796)1.58468299
94Encephalitis (HP:0002383)1.58034819
95Abnormality of T cell number (HP:0011839)1.57025862
96Fatigue (HP:0012378)1.55959075
97Heterotopia (HP:0002282)1.52603838
98Abnormality of T cell physiology (HP:0011840)1.52171675
99Disproportionate tall stature (HP:0001519)1.51421675
100Abnormality of the common coagulation pathway (HP:0010990)1.51287352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.07642002
2TRIB33.86567174
3MAP3K103.70461285
4CDK123.20814495
5ERN13.13162568
6EEF2K3.13129661
7SMG12.96267033
8MAP4K12.54446066
9ICK2.44210541
10SIK12.11944860
11RIPK42.11797654
12MAP3K131.94497989
13PKN21.78568575
14BLK1.72326859
15FGFR41.66597062
16MAP2K31.62293080
17KSR21.57029075
18GRK61.51091005
19MAP3K141.41636809
20TYK21.41467769
21CDK41.31778987
22BRD41.29248491
23IRAK41.22327469
24CSK1.18834133
25ZAP701.17801323
26JAK31.13807253
27CDK61.11619468
28FGFR31.11591774
29MARK21.09078210
30SIK21.08559604
31BTK1.03518451
32PASK1.02651477
33FES1.00318062
34IKBKE1.00243152
35MTOR0.99645530
36HCK0.97076890
37ITK0.94270572
38IRAK30.94075185
39MAP3K90.92935038
40MAPK110.90899725
41YES10.90147076
42PTK60.89831073
43MAPK150.89127383
44PDGFRA0.87966773
45JAK10.86059901
46RPS6KB20.83315563
47MELK0.81968148
48LRRK20.79202876
49MAP3K10.78423695
50PDPK10.78060015
51SGK30.77971284
52MAPK120.77661138
53RIPK10.77572608
54PRKD20.77179499
55HIPK20.73721176
56WNK10.72567491
57TBK10.71065236
58RPS6KL10.70826941
59RPS6KC10.70826941
60STK240.70132409
61PDK10.70101454
62CDC42BPA0.69940346
63JAK20.69699216
64IRAK20.69668023
65RET0.68716057
66TTN0.68200525
67RAF10.67084532
68SYK0.66880420
69MAP2K20.66368835
70TNK20.65933227
71TYRO30.65350799
72MAP3K70.62666894
73MAPK70.61618934
74MAP3K20.60557099
75NEK90.59849337
76SIK30.56539034
77PIM10.56481041
78LYN0.55835805
79LCK0.54105933
80CSF1R0.54002874
81STK100.53382964
82CDK70.52007432
83STK40.51678713
84RPS6KA60.51595908
85TAOK30.48755931
86RPS6KA20.47556673
87SGK20.46781464
88MAP3K30.46451456
89PAK40.44405011
90MOS0.43850484
91FGR0.43253864
92DYRK1B0.43082779
93CAMK1D0.41507340
94TAF10.41438041
95PTK20.40057966
96MAP3K80.39762558
97STK110.39175874
98CAMKK10.38781218
99PDGFRB0.38697048
100EPHB10.36951252

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.52043089
2Acute myeloid leukemia_Homo sapiens_hsa052212.34898615
3Non-small cell lung cancer_Homo sapiens_hsa052232.34166800
4Chronic myeloid leukemia_Homo sapiens_hsa052202.16973862
5Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75171553
6T cell receptor signaling pathway_Homo sapiens_hsa046601.73324328
7Primary immunodeficiency_Homo sapiens_hsa053401.72395904
8Pancreatic cancer_Homo sapiens_hsa052121.71533236
9Endometrial cancer_Homo sapiens_hsa052131.67035606
10Osteoclast differentiation_Homo sapiens_hsa043801.66021314
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62676934
12Thyroid cancer_Homo sapiens_hsa052161.52726224
13Other glycan degradation_Homo sapiens_hsa005111.52205565
14mTOR signaling pathway_Homo sapiens_hsa041501.50098388
15Leishmaniasis_Homo sapiens_hsa051401.49400525
16Notch signaling pathway_Homo sapiens_hsa043301.46577026
17Measles_Homo sapiens_hsa051621.45142317
18Hepatitis B_Homo sapiens_hsa051611.44111984
19VEGF signaling pathway_Homo sapiens_hsa043701.42913129
20Renal cell carcinoma_Homo sapiens_hsa052111.41642512
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38303134
22Colorectal cancer_Homo sapiens_hsa052101.38244502
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36661015
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.34250459
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.33744428
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.33560368
27Prostate cancer_Homo sapiens_hsa052151.28908092
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26010680
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25933295
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25838331
31Inositol phosphate metabolism_Homo sapiens_hsa005621.25598689
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23333525
33Herpes simplex infection_Homo sapiens_hsa051681.21853980
34Influenza A_Homo sapiens_hsa051641.21250646
35Bladder cancer_Homo sapiens_hsa052191.19223846
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.15888210
37Prolactin signaling pathway_Homo sapiens_hsa049171.15663053
38Small cell lung cancer_Homo sapiens_hsa052221.15305218
39Toxoplasmosis_Homo sapiens_hsa051451.14290370
40Apoptosis_Homo sapiens_hsa042101.14174013
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.13737372
42Hepatitis C_Homo sapiens_hsa051601.13548838
43Glioma_Homo sapiens_hsa052141.11175805
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09921111
45HTLV-I infection_Homo sapiens_hsa051661.07449543
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05310169
47ErbB signaling pathway_Homo sapiens_hsa040121.05227494
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05091959
49Viral carcinogenesis_Homo sapiens_hsa052031.04459461
50Tuberculosis_Homo sapiens_hsa051521.01701927
51Chemokine signaling pathway_Homo sapiens_hsa040621.00719048
52FoxO signaling pathway_Homo sapiens_hsa040681.00572836
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99191731
54Lysine degradation_Homo sapiens_hsa003100.99151095
55MicroRNAs in cancer_Homo sapiens_hsa052060.98781858
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98763264
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98361366
58Autoimmune thyroid disease_Homo sapiens_hsa053200.98170096
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97512650
60TNF signaling pathway_Homo sapiens_hsa046680.95759951
61Allograft rejection_Homo sapiens_hsa053300.94363664
62Choline metabolism in cancer_Homo sapiens_hsa052310.94041133
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.90164411
64Viral myocarditis_Homo sapiens_hsa054160.89838973
65Graft-versus-host disease_Homo sapiens_hsa053320.89673800
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.88104224
67Staphylococcus aureus infection_Homo sapiens_hsa051500.84320496
68Insulin signaling pathway_Homo sapiens_hsa049100.83646581
69GnRH signaling pathway_Homo sapiens_hsa049120.82674553
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82211558
71Epstein-Barr virus infection_Homo sapiens_hsa051690.80558503
72Insulin resistance_Homo sapiens_hsa049310.77689039
73Fructose and mannose metabolism_Homo sapiens_hsa000510.75713279
74mRNA surveillance pathway_Homo sapiens_hsa030150.75592800
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74208097
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73485264
77Proteoglycans in cancer_Homo sapiens_hsa052050.73228142
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72982897
79Hematopoietic cell lineage_Homo sapiens_hsa046400.72355616
80Antigen processing and presentation_Homo sapiens_hsa046120.71171579
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70904239
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70363177
83HIF-1 signaling pathway_Homo sapiens_hsa040660.69036904
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67494873
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.66131230
86Platelet activation_Homo sapiens_hsa046110.65382595
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.65154674
88Estrogen signaling pathway_Homo sapiens_hsa049150.62892773
89Focal adhesion_Homo sapiens_hsa045100.60881224
90Cell cycle_Homo sapiens_hsa041100.60505095
91Endocytosis_Homo sapiens_hsa041440.59549263
92Pathways in cancer_Homo sapiens_hsa052000.57763824
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56703780
94Long-term potentiation_Homo sapiens_hsa047200.55717781
95AMPK signaling pathway_Homo sapiens_hsa041520.55344220
96Prion diseases_Homo sapiens_hsa050200.54282066
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50860359
98N-Glycan biosynthesis_Homo sapiens_hsa005100.50235181
99MAPK signaling pathway_Homo sapiens_hsa040100.50068493
100Malaria_Homo sapiens_hsa051440.50019189

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