ZNF746

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.38436436
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.38436436
3modulation by symbiont of host immune response (GO:0052553)5.38436436
4positive regulation by symbiont of host defense response (GO:0052509)5.38436436
5modulation by symbiont of host defense response (GO:0052031)5.38436436
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.38436436
7positive regulation of gamma-delta T cell activation (GO:0046645)5.05181056
8negative regulation of cell killing (GO:0031342)4.91961843
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.91961843
10negative regulation of erythrocyte differentiation (GO:0045647)4.78806755
11cellular extravasation (GO:0045123)4.69234289
12response to peptidoglycan (GO:0032494)4.67281091
13macrophage activation involved in immune response (GO:0002281)4.59757563
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58505592
15neutrophil activation involved in immune response (GO:0002283)4.46714450
16detection of other organism (GO:0098543)4.03147769
17negative regulation of interleukin-12 production (GO:0032695)4.02947791
18detection of molecule of bacterial origin (GO:0032490)3.96748809
19regulation of B cell receptor signaling pathway (GO:0050855)3.88635192
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87728735
21response to muramyl dipeptide (GO:0032495)3.84074843
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.82883226
23regulation of gamma-delta T cell activation (GO:0046643)3.74449640
24detection of bacterium (GO:0016045)3.73339224
25antigen processing and presentation of endogenous antigen (GO:0019883)3.73164799
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.73130464
27regulation of interferon-beta biosynthetic process (GO:0045357)3.69268349
28microglial cell activation (GO:0001774)3.64874823
29detection of external biotic stimulus (GO:0098581)3.64476848
30leukocyte aggregation (GO:0070486)3.62616969
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.58508865
32response to host immune response (GO:0052572)3.58508865
33regulation of mast cell degranulation (GO:0043304)3.58030716
34macrophage activation (GO:0042116)3.51905965
35positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.49812442
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46073493
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.45209415
38response to host (GO:0075136)3.45209415
39response to host defenses (GO:0052200)3.45209415
40neutrophil activation (GO:0042119)3.45107157
41granulocyte activation (GO:0036230)3.31612412
42regulation of mast cell activation involved in immune response (GO:0033006)3.31039938
43regulation of gamma-delta T cell differentiation (GO:0045586)3.30660760
44neutrophil mediated immunity (GO:0002446)3.30599666
45positive regulation of histone deacetylation (GO:0031065)3.29763635
46regulation of leukocyte degranulation (GO:0043300)3.29071212
47detection of biotic stimulus (GO:0009595)3.28215089
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.24809527
49myeloid cell activation involved in immune response (GO:0002275)3.24529861
50respiratory burst (GO:0045730)3.23300421
51positive regulation of protein deacetylation (GO:0090312)3.20954766
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18201085
53leukocyte migration involved in inflammatory response (GO:0002523)3.11964844
54immunoglobulin mediated immune response (GO:0016064)3.10945892
55B cell receptor signaling pathway (GO:0050853)3.09802169
56germinal center formation (GO:0002467)3.06851023
57lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06835251
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.03206011
59negative regulation of leukocyte mediated immunity (GO:0002704)3.02745876
60positive regulation of mast cell activation (GO:0033005)2.99702126
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95781441
62negative regulation of T cell mediated immunity (GO:0002710)2.90252020
63response to interleukin-15 (GO:0070672)2.90191635
64defense response to protozoan (GO:0042832)2.90030829
65positive thymic T cell selection (GO:0045059)2.88868368
66histone H3-K36 demethylation (GO:0070544)2.83408244
67regulation of T-helper 2 cell differentiation (GO:0045628)2.83352208
68regulation of mast cell activation (GO:0033003)2.82657661
69regulation of necroptotic process (GO:0060544)2.81830495
70negative regulation of interleukin-6 production (GO:0032715)2.78954379
71positive regulation of B cell differentiation (GO:0045579)2.78854316
72negative regulation of toll-like receptor signaling pathway (GO:0034122)2.78231180
733-UTR-mediated mRNA stabilization (GO:0070935)2.77210071
74negative regulation of phagocytosis (GO:0050765)2.76816174
75regulation of T cell tolerance induction (GO:0002664)2.74787512
76regulation of regulated secretory pathway (GO:1903305)2.74319257
77tolerance induction (GO:0002507)2.73116188
78modulation by virus of host process (GO:0019054)2.70933045
79negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69577637
80positive regulation of mast cell degranulation (GO:0043306)2.69539901
81positive regulation of mast cell activation involved in immune response (GO:0033008)2.69539901
82negative regulation of cAMP-mediated signaling (GO:0043951)2.69466042
83myeloid leukocyte mediated immunity (GO:0002444)2.68987846
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.67355089
85production of molecular mediator involved in inflammatory response (GO:0002532)2.67090338
86positive regulation of Rap GTPase activity (GO:0032854)2.66978397
87regulation of B cell differentiation (GO:0045577)2.65508873
88regulation of tolerance induction (GO:0002643)2.65284631
89response to protozoan (GO:0001562)2.65100749
90regulation of erythrocyte differentiation (GO:0045646)2.62230980
91negative regulation of T-helper cell differentiation (GO:0045623)2.61180628
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.61180628
93leukocyte degranulation (GO:0043299)2.60418471
94modulation by symbiont of host cellular process (GO:0044068)2.59372443
95histone H3-K4 trimethylation (GO:0080182)2.58334102
96T cell homeostasis (GO:0043029)2.56877357
97T-helper 1 type immune response (GO:0042088)2.56254606
98positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55723858
99T cell selection (GO:0045058)2.54706379
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.54022680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.65429167
2MYC_22102868_ChIP-Seq_BL_Human3.38496608
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.35445571
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16256910
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96086004
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.89296792
7SCL_19346495_ChIP-Seq_HPC-7_Human2.84041995
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81601571
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.81259622
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.80192689
11VDR_24763502_ChIP-Seq_THP-1_Human2.80082589
12TCF7_22412390_ChIP-Seq_EML_Mouse2.79592697
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.64418587
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63720696
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.61707600
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59602527
17KDM2B_26808549_Chip-Seq_DND41_Human2.56257815
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50624472
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.45632341
20MAF_26560356_Chip-Seq_TH1_Human2.43224472
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.37305495
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.36360225
23SPI1_23127762_ChIP-Seq_K562_Human2.34925568
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25890889
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21345534
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19385971
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.16637276
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16156860
29UTX_26944678_Chip-Seq_JUKART_Human2.15554121
30STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14839773
31ELK3_25401928_ChIP-Seq_HUVEC_Human2.12211039
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08961521
33SPI1_23547873_ChIP-Seq_NB4_Human2.05338123
34RUNX_20019798_ChIP-Seq_JUKART_Human2.02974704
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.00858922
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99526682
37MAF_26560356_Chip-Seq_TH2_Human1.93447657
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93018018
39GATA1_19941826_ChIP-Seq_K562_Human1.92105689
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90247849
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.88852617
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82708914
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81078905
44MYB_26560356_Chip-Seq_TH1_Human1.80036055
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.78941630
46LXR_22292898_ChIP-Seq_THP-1_Human1.72939965
47MYB_26560356_Chip-Seq_TH2_Human1.70358877
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67715404
49KDM2B_26808549_Chip-Seq_K562_Human1.65196661
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64574131
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63989287
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58888519
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54758353
54NCOR1_26117541_ChIP-Seq_K562_Human1.45772386
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43467910
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39183388
57VDR_24787735_ChIP-Seq_THP-1_Human1.37277217
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35202935
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35096727
60RACK7_27058665_Chip-Seq_MCF-7_Human1.31019490
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28522753
62GATA2_19941826_ChIP-Seq_K562_Human1.27835179
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27801176
64GATA1_22025678_ChIP-Seq_K562_Human1.27550266
65PU_27001747_Chip-Seq_BMDM_Mouse1.26560363
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26438124
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25556986
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22223048
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21754068
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20523653
71GATA3_27048872_Chip-Seq_THYMUS_Human1.20487318
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17556550
73* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17099569
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16575023
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16091219
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15651180
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13852085
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08290749
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05333014
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04737061
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.02274292
82RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01858815
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01385569
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01112143
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.00290221
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99675406
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99355684
88P68_20966046_ChIP-Seq_HELA_Human0.99294162
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98572404
90* BCOR_27268052_Chip-Seq_Bcells_Human0.98465884
91TFEB_21752829_ChIP-Seq_HELA_Human0.98266977
92* BCL6_27268052_Chip-Seq_Bcells_Human0.98002029
93CIITA_25753668_ChIP-Seq_RAJI_Human0.96647617
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96391742
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95911534
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95528884
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95131225
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94334176
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93868490
100CREB1_26743006_Chip-Seq_LNCaP_Human0.93503635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.04655182
2MP0003724_increased_susceptibility_to3.76174019
3MP0003303_peritoneal_inflammation3.76121799
4MP0009278_abnormal_bone_marrow2.99605660
5MP0001835_abnormal_antigen_presentation2.84952052
6MP0002419_abnormal_innate_immunity2.81413999
7MP0001800_abnormal_humoral_immune2.48850231
8MP0000685_abnormal_immune_system2.42590453
9MP0005000_abnormal_immune_tolerance2.41645495
10MP0005025_abnormal_response_to2.39504082
11MP0001790_abnormal_immune_system2.37202074
12MP0005387_immune_system_phenotype2.37202074
13MP0008260_abnormal_autophagy2.35706135
14MP0003172_abnormal_lysosome_physiology2.34455517
15MP0005451_abnormal_body_composition2.31991826
16MP0005397_hematopoietic_system_phenotyp2.31924760
17MP0001545_abnormal_hematopoietic_system2.31924760
18MP0003300_gastrointestinal_ulcer2.27869485
19MP0002420_abnormal_adaptive_immunity2.25260883
20MP0002723_abnormal_immune_serum2.24420653
21MP0001819_abnormal_immune_cell2.23128631
22MP0003763_abnormal_thymus_physiology2.22458615
23MP0002452_abnormal_antigen_presenting2.22084643
24MP0002396_abnormal_hematopoietic_system2.20515680
25MP0002405_respiratory_system_inflammati2.10132284
26MP0003191_abnormal_cellular_cholesterol2.09831599
27MP0009785_altered_susceptibility_to2.05548638
28MP0002398_abnormal_bone_marrow2.01270530
29MP0005076_abnormal_cell_differentiation2.00823914
30MP0005671_abnormal_response_to1.95839956
31MP0003828_pulmonary_edema1.92881508
32MP0004808_abnormal_hematopoietic_stem1.90651109
33MP0005464_abnormal_platelet_physiology1.89209594
34MP0004947_skin_inflammation1.86158145
35MP0000716_abnormal_immune_system1.82653172
36MP0002148_abnormal_hypersensitivity_rea1.82587866
37MP0001533_abnormal_skeleton_physiology1.80567778
38MP0005083_abnormal_biliary_tract1.79826395
39MP0003656_abnormal_erythrocyte_physiolo1.68446978
40MP0000703_abnormal_thymus_morphology1.67031525
41MP0002722_abnormal_immune_system1.65637309
42MP0002132_abnormal_respiratory_system1.57465240
43MP0000689_abnormal_spleen_morphology1.56549639
44MP0006082_CNS_inflammation1.52744535
45MP0002429_abnormal_blood_cell1.52416540
46MP0003705_abnormal_hypodermis_morpholog1.51880178
47MP0005058_abnormal_lysosome_morphology1.51242308
48MP0005310_abnormal_salivary_gland1.46524607
49MP0004510_myositis1.46237446
50MP0004381_abnormal_hair_follicle1.45144968
51MP0009333_abnormal_splenocyte_physiolog1.42456542
52MP0002998_abnormal_bone_remodeling1.37556876
53MP0008057_abnormal_DNA_replication1.37000979
54MP0001845_abnormal_inflammatory_respons1.34490951
55MP0010155_abnormal_intestine_physiology1.34481373
56MP0008961_abnormal_basal_metabolism1.31152558
57MP0009840_abnormal_foam_cell1.21381464
58MP0009764_decreased_sensitivity_to1.21037704
59MP0000015_abnormal_ear_pigmentation1.17493576
60MP0000858_altered_metastatic_potential1.15226288
61MP0000465_gastrointestinal_hemorrhage1.13906064
62MP0003091_abnormal_cell_migration1.13256733
63MP0003453_abnormal_keratinocyte_physiol1.12273578
64MP0008469_abnormal_protein_level1.08770022
65MP0004185_abnormal_adipocyte_glucose1.08482949
66MP0003866_abnormal_defecation1.06498144
67MP0001851_eye_inflammation1.03430616
68MP0005409_darkened_coat_color1.02978463
69MP0009115_abnormal_fat_cell0.99901196
70MP0003075_altered_response_to0.99135091
71MP0003183_abnormal_peptide_metabolism0.96231949
72MP0008004_abnormal_stomach_pH0.95935128
73MP0001873_stomach_inflammation0.88517591
74MP0003045_fibrosis0.83937424
75MP0004883_abnormal_blood_vessel0.81697274
76MP0004233_abnormal_muscle_weight0.79698576
77MP0004130_abnormal_muscle_cell0.79589854
78MP0010307_abnormal_tumor_latency0.78452984
79MP0000343_altered_response_to0.78372056
80MP0003690_abnormal_glial_cell0.78350325
81MP0005390_skeleton_phenotype0.78196777
82MP0005375_adipose_tissue_phenotype0.76004637
83MP0002166_altered_tumor_susceptibility0.74816888
84MP0005164_abnormal_response_to0.74656353
85MP0005621_abnormal_cell_physiology0.73732744
86MP0000371_diluted_coat_color0.72925365
87MP0000490_abnormal_crypts_of0.72900881
88MP0004858_abnormal_nervous_system0.69579155
89MP0000604_amyloidosis0.68385212
90MP0001915_intracranial_hemorrhage0.67135948
91MP0003448_altered_tumor_morphology0.66957689
92MP0002933_joint_inflammation0.66060261
93MP0002019_abnormal_tumor_incidence0.66011312
94MP0002332_abnormal_exercise_endurance0.64698610
95MP0001853_heart_inflammation0.64540959
96MP0008874_decreased_physiological_sensi0.64213125
97MP0003795_abnormal_bone_structure0.63739026
98MP0005666_abnormal_adipose_tissue0.62616180
99MP0005334_abnormal_fat_pad0.62474911
100MP0009931_abnormal_skin_appearance0.61445498

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.41579444
2Recurrent abscess formation (HP:0002722)5.19581748
3Recurrent bacterial skin infections (HP:0005406)5.11504445
4Myositis (HP:0100614)4.55595501
5Abnormality of macrophages (HP:0004311)4.36907407
6Orchitis (HP:0100796)4.24087857
7Stomatitis (HP:0010280)3.85979208
8Retrobulbar optic neuritis (HP:0100654)3.81554122
9Optic neuritis (HP:0100653)3.81554122
10Spontaneous hematomas (HP:0007420)3.80506087
11Recurrent gram-negative bacterial infections (HP:0005420)3.62577935
12Recurrent fungal infections (HP:0002841)3.57641648
13Chronic obstructive pulmonary disease (HP:0006510)3.51583135
14Obstructive lung disease (HP:0006536)3.51583135
15Mediastinal lymphadenopathy (HP:0100721)3.46157334
16Abnormality of the fingertips (HP:0001211)3.45100918
17Elevated erythrocyte sedimentation rate (HP:0003565)3.32771399
18Meningitis (HP:0001287)3.22948298
19Cellulitis (HP:0100658)3.22893684
20Hypochromic microcytic anemia (HP:0004840)3.21459453
21Gastrointestinal infarctions (HP:0005244)3.17276725
22Gingivitis (HP:0000230)3.16366890
23Recurrent skin infections (HP:0001581)3.15224976
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.10449202
25Prolonged bleeding time (HP:0003010)3.02558999
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.01860555
27Increased IgE level (HP:0003212)2.88397233
28Recurrent viral infections (HP:0004429)2.73439024
29Vasculitis (HP:0002633)2.72707023
30Keratoconjunctivitis sicca (HP:0001097)2.72501879
31Chest pain (HP:0100749)2.71744874
32Hypochromic anemia (HP:0001931)2.71442406
33Recurrent cutaneous fungal infections (HP:0011370)2.71195738
34Chronic mucocutaneous candidiasis (HP:0002728)2.71195738
35Urticaria (HP:0001025)2.67448230
36Episodic fever (HP:0001954)2.64508119
37Increased cerebral lipofuscin (HP:0011813)2.62634721
38Encephalitis (HP:0002383)2.59957361
39Gastrointestinal inflammation (HP:0004386)2.53815274
40Inflammation of the large intestine (HP:0002037)2.51006355
41Microcytic anemia (HP:0001935)2.50559703
42Epistaxis (HP:0000421)2.43718001
43Hemoptysis (HP:0002105)2.40536110
44Keratoconjunctivitis (HP:0001096)2.35152076
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.34719364
46T lymphocytopenia (HP:0005403)2.33994761
47Panhypogammaglobulinemia (HP:0003139)2.32599444
48Subacute progressive viral hepatitis (HP:0006572)2.31058581
49Colitis (HP:0002583)2.30359071
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.29987626
51Slow saccadic eye movements (HP:0000514)2.29371266
52Arterial thrombosis (HP:0004420)2.25347041
53Obstructive sleep apnea (HP:0002870)2.25331325
54Leukocytosis (HP:0001974)2.25242269
55Pulmonary infiltrates (HP:0002113)2.25164178
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24840793
57Osteomyelitis (HP:0002754)2.20759958
58Viral hepatitis (HP:0006562)2.19073499
59Gingival bleeding (HP:0000225)2.17900701
60Pustule (HP:0200039)2.15479736
61Peritonitis (HP:0002586)2.10969844
62Petechiae (HP:0000967)2.10682181
63Sepsis (HP:0100806)2.06134531
64Loss of speech (HP:0002371)2.05001066
65Abnormality of the columella (HP:0009929)2.04180067
66Abnormality of T cell number (HP:0011839)2.04152928
67Anorexia (HP:0002039)2.04087911
68Granulocytopenia (HP:0001913)2.01700413
69Pulmonary embolism (HP:0002204)1.96846764
70Autoimmune thrombocytopenia (HP:0001973)1.95362799
71Lymphopenia (HP:0001888)1.93330310
72Neonatal hypoglycemia (HP:0001998)1.93269787
73Polycythemia (HP:0001901)1.89501335
74Abnormality of liposaccharide metabolism (HP:0010968)1.88940536
75Abnormality of glycosphingolipid metabolism (HP:0004343)1.88940536
76Abnormality of glycolipid metabolism (HP:0010969)1.88940536
77Abnormality of the peritoneum (HP:0002585)1.86349391
78Abnormality of T cells (HP:0002843)1.84578672
79Increased serum ferritin (HP:0003281)1.84513846
80Long eyelashes (HP:0000527)1.84325733
81Amyloidosis (HP:0011034)1.80850142
82Acne (HP:0001061)1.79095154
83Aplasia/Hypoplasia of the thymus (HP:0010515)1.77593961
84Hypertensive crisis (HP:0100735)1.76837008
85Metaphyseal cupping (HP:0003021)1.74818951
86Abnormality of cells of the lymphoid lineage (HP:0012140)1.74144503
87Abnormality of the endocardium (HP:0004306)1.73651658
88Abnormal platelet volume (HP:0011876)1.73438352
89Abnormality of the pericardium (HP:0001697)1.70849363
90Abnormality of the pleura (HP:0002103)1.68220201
91Autoimmune hemolytic anemia (HP:0001890)1.67018082
92Broad face (HP:0000283)1.66668983
93Upper motor neuron abnormality (HP:0002127)1.65675606
94Abnormality of iron homeostasis (HP:0011031)1.65577255
95Ocular albinism (HP:0001107)1.64929650
96Segmental peripheral demyelination/remyelination (HP:0003481)1.64398542
97Long palpebral fissure (HP:0000637)1.62613782
98Glomerulopathy (HP:0100820)1.62276105
99Fatigue (HP:0012378)1.61768546
100Polygenic inheritance (HP:0010982)1.60847288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.34350218
2PRPF4B3.19802772
3CDK123.04308608
4ERN12.94378102
5MAP2K32.86341850
6MAP4K12.85379056
7TRIB32.54825908
8IRAK42.47674530
9CAMK1D2.35324483
10BLK2.27346728
11TAOK12.13368278
12SMG12.03758086
13TNK21.93145285
14CSK1.92813056
15CAMK1G1.89769097
16TYK21.88217547
17MARK21.65760765
18MAP3K31.64415413
19SIK11.60822349
20IRAK31.58419770
21ZAP701.57069833
22GRK61.53446624
23MAP3K111.48719191
24PRKD21.47434069
25FES1.44572778
26ICK1.43217479
27BTK1.36379429
28IKBKE1.35253162
29MAP3K141.35228687
30TAOK21.31784397
31HCK1.30310117
32MAP3K131.29848986
33MAP3K11.29514147
34JAK31.22822779
35KSR21.21966603
36SIK21.19562419
37HIPK21.16082871
38MAP3K71.13041272
39SIK31.11846568
40TBK11.11384746
41FGR1.11321716
42EPHB11.11165920
43SYK1.09744493
44IRAK21.08247749
45PIM11.07019104
46MARK31.03829118
47SGK31.01553848
48JAK20.99185066
49IKBKB0.91620076
50WNK10.91575203
51LRRK20.89972261
52CDC42BPA0.87239499
53STK100.85006229
54MELK0.81483506
55IRAK10.79611699
56SGK20.79030976
57LYN0.78181141
58CHUK0.77904140
59MATK0.77811038
60JAK10.77604950
61MAP3K100.77555201
62PDPK10.75775622
63MTOR0.75596203
64EEF2K0.75038990
65YES10.75006875
66PDK10.74802878
67RPS6KC10.74544632
68RPS6KL10.74544632
69PTK60.73432598
70TXK0.72625775
71LCK0.71945344
72RAF10.71365357
73TAOK30.70025087
74MAP3K20.68871258
75BRD40.67087281
76AKT30.66934658
77STK110.66394012
78STK380.65585258
79RIPK10.64894049
80CAMK40.63483365
81RPS6KA60.63199161
82CSF1R0.61518567
83MAPK120.55542273
84BMX0.54495728
85CAMKK10.52989674
86MAP3K60.52620468
87TGFBR20.51555528
88CDK40.48643529
89MAPK70.48500791
90MAPK110.48272473
91PRKCH0.48262868
92DYRK30.47755034
93KIT0.47555041
94FGFR30.46749598
95PDGFRB0.46682857
96ITK0.46462957
97RPS6KA20.45210100
98NLK0.44538851
99STK40.43573769
100PKN20.41994535

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.65614582
2B cell receptor signaling pathway_Homo sapiens_hsa046622.26640939
3Acute myeloid leukemia_Homo sapiens_hsa052212.23703930
4Leishmaniasis_Homo sapiens_hsa051402.22405641
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93411567
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88327847
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83977481
8Non-small cell lung cancer_Homo sapiens_hsa052231.80216794
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.80172121
10Chronic myeloid leukemia_Homo sapiens_hsa052201.77593059
11Tuberculosis_Homo sapiens_hsa051521.71874386
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64673963
13Staphylococcus aureus infection_Homo sapiens_hsa051501.62285800
14Malaria_Homo sapiens_hsa051441.61955162
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60448336
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.58121804
17T cell receptor signaling pathway_Homo sapiens_hsa046601.54720917
18TNF signaling pathway_Homo sapiens_hsa046681.53885274
19Notch signaling pathway_Homo sapiens_hsa043301.53706694
20Measles_Homo sapiens_hsa051621.50738656
21Pancreatic cancer_Homo sapiens_hsa052121.48773407
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41597811
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38822384
24Hepatitis B_Homo sapiens_hsa051611.38736234
25Influenza A_Homo sapiens_hsa051641.37790843
26Toxoplasmosis_Homo sapiens_hsa051451.35954529
27Chemokine signaling pathway_Homo sapiens_hsa040621.35779632
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34817427
29Renal cell carcinoma_Homo sapiens_hsa052111.34369734
30Other glycan degradation_Homo sapiens_hsa005111.30785072
31Endometrial cancer_Homo sapiens_hsa052131.27875967
32VEGF signaling pathway_Homo sapiens_hsa043701.27231475
33Primary immunodeficiency_Homo sapiens_hsa053401.26860491
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.25025002
35Herpes simplex infection_Homo sapiens_hsa051681.24590565
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.19690310
37FoxO signaling pathway_Homo sapiens_hsa040681.15750575
38Hepatitis C_Homo sapiens_hsa051601.14554079
39Graft-versus-host disease_Homo sapiens_hsa053321.13753091
40Allograft rejection_Homo sapiens_hsa053301.12775334
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12640842
42mTOR signaling pathway_Homo sapiens_hsa041501.11430162
43Prolactin signaling pathway_Homo sapiens_hsa049171.10167789
44Apoptosis_Homo sapiens_hsa042101.08590276
45Legionellosis_Homo sapiens_hsa051341.08118788
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05914029
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05387488
48Platelet activation_Homo sapiens_hsa046111.05203510
49Colorectal cancer_Homo sapiens_hsa052101.04388206
50African trypanosomiasis_Homo sapiens_hsa051431.01751091
51ErbB signaling pathway_Homo sapiens_hsa040121.01416928
52Hematopoietic cell lineage_Homo sapiens_hsa046401.00030921
53Prostate cancer_Homo sapiens_hsa052150.98347439
54Bladder cancer_Homo sapiens_hsa052190.98149594
55Viral carcinogenesis_Homo sapiens_hsa052030.96729224
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.95073405
57Inositol phosphate metabolism_Homo sapiens_hsa005620.94832803
58Autoimmune thyroid disease_Homo sapiens_hsa053200.94592603
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93954791
60Dorso-ventral axis formation_Homo sapiens_hsa043200.93378384
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.92271307
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.91994057
63Lysosome_Homo sapiens_hsa041420.90674188
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90351582
65Type II diabetes mellitus_Homo sapiens_hsa049300.88224032
66Choline metabolism in cancer_Homo sapiens_hsa052310.87728801
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86427462
68Thyroid cancer_Homo sapiens_hsa052160.85634472
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.85339350
70Glioma_Homo sapiens_hsa052140.84498344
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83857506
72Epstein-Barr virus infection_Homo sapiens_hsa051690.83657544
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83598763
74Phagosome_Homo sapiens_hsa041450.81083837
75HTLV-I infection_Homo sapiens_hsa051660.80672367
76Viral myocarditis_Homo sapiens_hsa054160.80522163
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80169689
78Antigen processing and presentation_Homo sapiens_hsa046120.79540215
79Salmonella infection_Homo sapiens_hsa051320.76721037
80HIF-1 signaling pathway_Homo sapiens_hsa040660.73532662
81Shigellosis_Homo sapiens_hsa051310.73422810
82Endocytosis_Homo sapiens_hsa041440.72864625
83Insulin resistance_Homo sapiens_hsa049310.72555988
84Amoebiasis_Homo sapiens_hsa051460.72184314
85MAPK signaling pathway_Homo sapiens_hsa040100.72122031
86Pertussis_Homo sapiens_hsa051330.71129871
87GnRH signaling pathway_Homo sapiens_hsa049120.70117802
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67776114
89Type I diabetes mellitus_Homo sapiens_hsa049400.67168509
90Estrogen signaling pathway_Homo sapiens_hsa049150.63694987
91MicroRNAs in cancer_Homo sapiens_hsa052060.62805423
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.59562982
93Small cell lung cancer_Homo sapiens_hsa052220.59499435
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58569058
95Insulin signaling pathway_Homo sapiens_hsa049100.57611814
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.55747472
97Rap1 signaling pathway_Homo sapiens_hsa040150.54677368
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53472871
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53196150
100Rheumatoid arthritis_Homo sapiens_hsa053230.52236623

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