ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.21843955
2	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.29878009
3	L-fucose metabolic process (GO:0042354)	4.26996732
4	L-fucose catabolic process (GO:0042355)	4.26996732
5	fucose catabolic process (GO:0019317)	4.26996732
6	protein complex biogenesis (GO:0070271)	4.23916896
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.12129969
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.12129969
9	NADH dehydrogenase complex assembly (GO:0010257)	4.12129969
10	indole-containing compound catabolic process (GO:0042436)	4.12002023
11	indolalkylamine catabolic process (GO:0046218)	4.12002023
12	tryptophan catabolic process (GO:0006569)	4.12002023
13	ubiquinone biosynthetic process (GO:0006744)	4.00032035
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.99692642
15	base-excision repair, AP site formation (GO:0006285)	3.83370818
16	pyrimidine nucleotide catabolic process (GO:0006244)	3.82867417
17	viral transcription (GO:0019083)	3.74196011
18	maturation of SSU-rRNA (GO:0030490)	3.57283420
19	translational termination (GO:0006415)	3.53012644
20	negative regulation of telomere maintenance (GO:0032205)	3.52416956
21	kynurenine metabolic process (GO:0070189)	3.51430818
22	behavioral response to nicotine (GO:0035095)	3.50224840
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.50221035
24	preassembly of GPI anchor in ER membrane (GO:0016254)	3.48540926
25	protein-cofactor linkage (GO:0018065)	3.44276513
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.42816772
27	ATP synthesis coupled proton transport (GO:0015986)	3.42816772
28	ubiquinone metabolic process (GO:0006743)	3.42729039
29	cytochrome complex assembly (GO:0017004)	3.42553983
30	tryptophan metabolic process (GO:0006568)	3.42266238
31	platelet dense granule organization (GO:0060155)	3.39289811
32	deoxyribonucleotide catabolic process (GO:0009264)	3.37393290
33	indolalkylamine metabolic process (GO:0006586)	3.36916293
34	quinone biosynthetic process (GO:1901663)	3.36578693
35	negative regulation of cAMP-mediated signaling (GO:0043951)	3.35921267
36	respiratory chain complex IV assembly (GO:0008535)	3.35898697
37	ribosomal small subunit biogenesis (GO:0042274)	3.31109073
38	ribosomal small subunit assembly (GO:0000028)	3.27745777
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.27015035
40	translational elongation (GO:0006414)	3.19812240
41	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.18017340
42	electron transport chain (GO:0022900)	3.17018170
43	cellular biogenic amine catabolic process (GO:0042402)	3.12917822
44	amine catabolic process (GO:0009310)	3.12917822
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.12539254
46	respiratory electron transport chain (GO:0022904)	3.12514747
47	pseudouridine synthesis (GO:0001522)	3.10330402
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09830704
49	mannosylation (GO:0097502)	3.01714303
50	GTP biosynthetic process (GO:0006183)	3.00148125
51	piRNA metabolic process (GO:0034587)	2.97825959
52	deoxyribose phosphate catabolic process (GO:0046386)	2.95701934
53	aromatic amino acid family catabolic process (GO:0009074)	2.93073205
54	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.92663438
55	protein targeting to ER (GO:0045047)	2.91684134
56	purine deoxyribonucleotide catabolic process (GO:0009155)	2.90732076
57	cotranslational protein targeting to membrane (GO:0006613)	2.86234471
58	regulation of mitochondrial translation (GO:0070129)	2.80859630
59	positive regulation of prostaglandin secretion (GO:0032308)	2.80390989
60	positive regulation of fatty acid transport (GO:2000193)	2.78023664
61	negative regulation of B cell apoptotic process (GO:0002903)	2.75834432
62	protein localization to endoplasmic reticulum (GO:0070972)	2.74749992
63	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.71072350
64	viral life cycle (GO:0019058)	2.70851051
65	cellular ketone body metabolic process (GO:0046950)	2.69440949
66	UTP metabolic process (GO:0046051)	2.68341152
67	metallo-sulfur cluster assembly (GO:0031163)	2.65199224
68	iron-sulfur cluster assembly (GO:0016226)	2.65199224
69	tRNA modification (GO:0006400)	2.62607969
70	UTP biosynthetic process (GO:0006228)	2.62410629
71	oxidative demethylation (GO:0070989)	2.61873389
72	protein polyglutamylation (GO:0018095)	2.56360982
73	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.55836403
74	tRNA processing (GO:0008033)	2.55484765
75	S-adenosylmethionine metabolic process (GO:0046500)	2.51504993
76	peptidyl-histidine modification (GO:0018202)	2.50274491
77	response to pheromone (GO:0019236)	2.47821935
78	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.47287833
79	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.47287833
80	hydrogen ion transmembrane transport (GO:1902600)	2.46565765
81	anterograde synaptic vesicle transport (GO:0048490)	2.45226841
82	positive regulation of defense response to virus by host (GO:0002230)	2.45142071
83	indole-containing compound metabolic process (GO:0042430)	2.43817341
84	cellular component biogenesis (GO:0044085)	2.43115069
85	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.42291524
86	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.42109678
87	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.42109678
88	positive regulation of protein homodimerization activity (GO:0090073)	2.41926791
89	chaperone-mediated protein transport (GO:0072321)	2.41882610
90	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.41295517
91	cellular protein complex disassembly (GO:0043624)	2.41120091
92	NAD biosynthetic process (GO:0009435)	2.40616420
93	positive regulation of icosanoid secretion (GO:0032305)	2.40242623
94	protein localization to cilium (GO:0061512)	2.38497118
95	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.38171690
96	inositol phosphate dephosphorylation (GO:0046855)	2.38171690
97	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.37792342
98	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.36172588
99	axoneme assembly (GO:0035082)	2.34450782
100	proton transport (GO:0015992)	2.34051111

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.98685537
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.18433700
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.31264828
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.04395116
5	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04190919
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.93464103
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.81539998
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.75146430
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.62987680
10	* ETS1_20019798_ChIP-Seq_JURKAT_Human	2.50850506
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.49258091
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.49245296
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.29730182
14	* FOXP3_21729870_ChIP-Seq_TREG_Human	2.21295814
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.18849931
16	VDR_22108803_ChIP-Seq_LS180_Human	2.15321449
17	IRF1_19129219_ChIP-ChIP_H3396_Human	2.09950606
18	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.07470969
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05893075
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.04575915
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.99427229
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.97010670
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.95432329
24	* CIITA_25753668_ChIP-Seq_RAJI_Human	1.91133001
25	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.85280340
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.82872089
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.74339602
28	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.66558235
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62203686
30	KDM5A_27292631_Chip-Seq_BREAST_Human	1.53086806
31	* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.52086565
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.51895706
33	* ERA_21632823_ChIP-Seq_H3396_Human	1.51551698
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.48748148
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.45175432
36	BCL6_27268052_Chip-Seq_Bcells_Human	1.41758094
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.40323115
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.39920189
39	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.38055687
40	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.37764165
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.37491774
42	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35928966
43	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.35043275
44	* E2F1_20622854_ChIP-Seq_HELA_Human	1.32961562
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.29645144
46	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29398624
47	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.29296624
48	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.27535314
49	VDR_21846776_ChIP-Seq_THP-1_Human	1.26324919
50	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25942475
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25109565
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25078946
53	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.24432233
54	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24330644
55	IGF1R_20145208_ChIP-Seq_DFB_Human	1.23591233
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.21185251
57	* PHF8_20622854_ChIP-Seq_HELA_Human	1.19353614
58	* P300_27268052_Chip-Seq_Bcells_Human	1.17977829
59	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.17188526
60	P68_20966046_ChIP-Seq_HELA_Human	1.17127790
61	* TTF2_22483619_ChIP-Seq_HELA_Human	1.17121899
62	OCT4_20526341_ChIP-Seq_ESCs_Human	1.15774916
63	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.13320601
64	* BCOR_27268052_Chip-Seq_Bcells_Human	1.12597996
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12256716
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11427630
67	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10173179
68	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.10163285
69	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.08229241
70	AR_20517297_ChIP-Seq_VCAP_Human	1.06789145
71	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.06428692
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06367531
73	P53_21459846_ChIP-Seq_SAOS-2_Human	1.05115786
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05049288
75	* RAC3_21632823_ChIP-Seq_H3396_Human	1.05008589
76	NCOR_22424771_ChIP-Seq_293T_Human	1.03222681
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02082698
78	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01427242
79	* MYC_19829295_ChIP-Seq_ESCs_Human	1.00397449
80	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.00068340
81	EWS_26573619_Chip-Seq_HEK293_Human	0.98223161
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97343798
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97343798
84	FUS_26573619_Chip-Seq_HEK293_Human	0.97018409
85	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.96729239
86	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.96703180
87	SA1_27219007_Chip-Seq_Bcells_Human	0.96476669
88	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.95927694
89	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.95092304
90	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94748383
91	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94746084
92	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94611302
93	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.93304542
94	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.93194051
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.91829208
96	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.91460988
97	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89761750
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89731950
99	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89281676
100	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.88138218

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.99743872
2	MP0002653_abnormal_ependyma_morphology	2.77378603
3	MP0003195_calcinosis	2.64332724
4	MP0008877_abnormal_DNA_methylation	2.63099035
5	MP0002837_dystrophic_cardiac_calcinosis	2.60264670
6	MP0003787_abnormal_imprinting	2.34375314
7	MP0001968_abnormal_touch/_nociception	2.10050715
8	MP0002163_abnormal_gland_morphology	2.07671443
9	MP0005645_abnormal_hypothalamus_physiol	2.04496168
10	MP0006072_abnormal_retinal_apoptosis	1.94797623
11	MP0001986_abnormal_taste_sensitivity	1.87017153
12	MP0008875_abnormal_xenobiotic_pharmacok	1.85654607
13	MP0002138_abnormal_hepatobiliary_system	1.82803468
14	MP0001764_abnormal_homeostasis	1.82745026
15	MP0008058_abnormal_DNA_repair	1.77734447
16	MP0003011_delayed_dark_adaptation	1.73211063
17	MP0002876_abnormal_thyroid_physiology	1.71126276
18	MP0005551_abnormal_eye_electrophysiolog	1.69352490
19	MP0006036_abnormal_mitochondrial_physio	1.68865228
20	MP0002638_abnormal_pupillary_reflex	1.65342417
21	MP0004133_heterotaxia	1.63373860
22	MP0008995_early_reproductive_senescence	1.61976091
23	MP0005075_abnormal_melanosome_morpholog	1.58560590
24	MP0002102_abnormal_ear_morphology	1.55273928
25	MP0005646_abnormal_pituitary_gland	1.55025545
26	MP0008789_abnormal_olfactory_epithelium	1.54036288
27	MP0005671_abnormal_response_to	1.50466233
28	MP0004043_abnormal_pH_regulation	1.49590627
29	MP0005379_endocrine/exocrine_gland_phen	1.48177681
30	MP0008872_abnormal_physiological_respon	1.48173810
31	MP0005394_taste/olfaction_phenotype	1.39821081
32	MP0005499_abnormal_olfactory_system	1.39821081
33	MP0002928_abnormal_bile_duct	1.32142281
34	MP0004142_abnormal_muscle_tone	1.29023557
35	MP0005253_abnormal_eye_physiology	1.28330738
36	MP0002277_abnormal_respiratory_mucosa	1.24239704
37	MP0003806_abnormal_nucleotide_metabolis	1.22351794
38	MP0003718_maternal_effect	1.22100445
39	MP0009278_abnormal_bone_marrow	1.19483795
40	MP0003646_muscle_fatigue	1.19156435
41	MP0002736_abnormal_nociception_after	1.19092268
42	MP0005360_urolithiasis	1.18369619
43	MP0005084_abnormal_gallbladder_morpholo	1.18268539
44	MP0000631_abnormal_neuroendocrine_gland	1.16549803
45	MP0000372_irregular_coat_pigmentation	1.15085396
46	MP0001800_abnormal_humoral_immune	1.13870166
47	MP0006035_abnormal_mitochondrial_morpho	1.13644140
48	MP0001905_abnormal_dopamine_level	1.12869005
49	MP0003880_abnormal_central_pattern	1.12002527
50	MP0009333_abnormal_splenocyte_physiolog	1.11889111
51	MP0010094_abnormal_chromosome_stability	1.11817770
52	MP0002160_abnormal_reproductive_system	1.11371537
53	MP0005389_reproductive_system_phenotype	1.11308204
54	MP0003763_abnormal_thymus_physiology	1.09687096
55	MP0009379_abnormal_foot_pigmentation	1.09166076
56	MP0002132_abnormal_respiratory_system	1.07879044
57	MP0000685_abnormal_immune_system	1.06395586
58	MP0004130_abnormal_muscle_cell	1.04348586
59	MP0003172_abnormal_lysosome_physiology	1.04219338
60	MP0005365_abnormal_bile_salt	1.02578918
61	MP0001293_anophthalmia	1.00841851
62	MP0004147_increased_porphyrin_level	0.98785776
63	MP0003786_premature_aging	0.98063010
64	MP0010386_abnormal_urinary_bladder	0.97896488
65	MP0001919_abnormal_reproductive_system	0.97257673
66	MP0005220_abnormal_exocrine_pancreas	0.95782702
67	MP0003121_genomic_imprinting	0.95216562
68	MP0009745_abnormal_behavioral_response	0.93918723
69	MP0006276_abnormal_autonomic_nervous	0.92379014
70	MP0005085_abnormal_gallbladder_physiolo	0.92085371
71	MP0001984_abnormal_olfaction	0.90857560
72	MP0002733_abnormal_thermal_nociception	0.90824530
73	MP0002693_abnormal_pancreas_physiology	0.89949185
74	MP0004885_abnormal_endolymph	0.88972893
75	MP0005332_abnormal_amino_acid	0.88767653
76	MP0003136_yellow_coat_color	0.88440868
77	MP0001485_abnormal_pinna_reflex	0.87061508
78	MP0001790_abnormal_immune_system	0.86164415
79	MP0005387_immune_system_phenotype	0.86164415
80	MP0001270_distended_abdomen	0.85400211
81	MP0001944_abnormal_pancreas_morphology	0.85246183
82	MP0002272_abnormal_nervous_system	0.84591309
83	MP0003283_abnormal_digestive_organ	0.84454060
84	MP0004145_abnormal_muscle_electrophysio	0.81183582
85	MP0005167_abnormal_blood-brain_barrier	0.80422496
86	MP0001819_abnormal_immune_cell	0.80383756
87	MP0002420_abnormal_adaptive_immunity	0.80252171
88	MP0001501_abnormal_sleep_pattern	0.79685426
89	MP0004742_abnormal_vestibular_system	0.79632823
90	MP0002735_abnormal_chemical_nociception	0.79628014
91	MP0002723_abnormal_immune_serum	0.79616728
92	MP0000689_abnormal_spleen_morphology	0.79555753
93	MP0002234_abnormal_pharynx_morphology	0.79460751
94	MP0005174_abnormal_tail_pigmentation	0.79444809
95	MP0001835_abnormal_antigen_presentation	0.78720138
96	MP0005195_abnormal_posterior_eye	0.77156263
97	MP0003122_maternal_imprinting	0.77057784
98	MP0009764_decreased_sensitivity_to	0.76476684
99	MP0001486_abnormal_startle_reflex	0.76394502
100	MP0003186_abnormal_redox_activity	0.75703303

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.36318968
2	Abnormal number of erythroid precursors (HP:0012131)	3.95756050
3	Abnormality of cells of the erythroid lineage (HP:0012130)	3.68572598
4	Pancreatic cysts (HP:0001737)	3.55221742
5	Mitochondrial inheritance (HP:0001427)	3.41376199
6	Hepatocellular necrosis (HP:0001404)	3.36769399
7	Hepatic necrosis (HP:0002605)	3.31301953
8	Type II lissencephaly (HP:0007260)	3.28149594
9	Abnormal biliary tract physiology (HP:0012439)	3.25844699
10	Bile duct proliferation (HP:0001408)	3.25844699
11	Acute necrotizing encephalopathy (HP:0006965)	3.23735728
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.06523680
13	Abnormality of the renal cortex (HP:0011035)	3.04264480
14	Increased CSF lactate (HP:0002490)	2.97253803
15	Acute encephalopathy (HP:0006846)	2.97153223
16	Pancreatic fibrosis (HP:0100732)	2.94468867
17	Molar tooth sign on MRI (HP:0002419)	2.90247872
18	Abnormality of midbrain morphology (HP:0002418)	2.90247872
19	Progressive macrocephaly (HP:0004481)	2.77193765
20	Lipid accumulation in hepatocytes (HP:0006561)	2.68727713
21	3-Methylglutaconic aciduria (HP:0003535)	2.61662565
22	Medial flaring of the eyebrow (HP:0010747)	2.56755830
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.56196097
24	Chronic hepatic failure (HP:0100626)	2.54806929
25	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.46060533
26	Reticulocytopenia (HP:0001896)	2.44059384
27	True hermaphroditism (HP:0010459)	2.43400182
28	Nephronophthisis (HP:0000090)	2.41900944
29	Renal cortical cysts (HP:0000803)	2.39791095
30	Abolished electroretinogram (ERG) (HP:0000550)	2.35385921
31	Abnormal protein glycosylation (HP:0012346)	2.34337203
32	Abnormal glycosylation (HP:0012345)	2.34337203
33	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.34337203
34	Abnormal protein N-linked glycosylation (HP:0012347)	2.34337203
35	Abnormal drinking behavior (HP:0030082)	2.33391021
36	Polydipsia (HP:0001959)	2.33391021
37	Polyuria (HP:0000103)	2.32464409
38	Increased muscle lipid content (HP:0009058)	2.31276546
39	Increased serum lactate (HP:0002151)	2.31038779
40	Abnormality of the renal medulla (HP:0100957)	2.28405631
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.26638209
42	Stomach cancer (HP:0012126)	2.21665480
43	Colon cancer (HP:0003003)	2.18305078
44	Attenuation of retinal blood vessels (HP:0007843)	2.17807970
45	Abnormality of B cell number (HP:0010975)	2.17328664
46	Reduced antithrombin III activity (HP:0001976)	2.15901223
47	Lactic acidosis (HP:0003128)	2.15828354
48	Ketosis (HP:0001946)	2.15379062
49	Cystic liver disease (HP:0006706)	2.15164426
50	Absent thumb (HP:0009777)	2.14377067
51	Optic disc pallor (HP:0000543)	2.11245582
52	Cerebellar dysplasia (HP:0007033)	2.10805572
53	Tubular atrophy (HP:0000092)	2.10032108
54	Asplenia (HP:0001746)	2.08376671
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.07550403
56	Cerebral edema (HP:0002181)	2.06478493
57	Clumsiness (HP:0002312)	2.06402134
58	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.04817135
59	Panhypogammaglobulinemia (HP:0003139)	2.03985879
60	Pendular nystagmus (HP:0012043)	2.02281722
61	Delayed CNS myelination (HP:0002188)	2.00043050
62	Lethargy (HP:0001254)	1.98806623
63	Type I transferrin isoform profile (HP:0003642)	1.98581330
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.98424498
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.98424498
66	Hypoplasia of the pons (HP:0012110)	1.96113149
67	Increased intramyocellular lipid droplets (HP:0012240)	1.95918940
68	Increased hepatocellular lipid droplets (HP:0006565)	1.90665726
69	Dicarboxylic aciduria (HP:0003215)	1.90664495
70	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.90664495
71	Hypomagnesemia (HP:0002917)	1.90310923
72	Congenital hepatic fibrosis (HP:0002612)	1.89041398
73	Supernumerary spleens (HP:0009799)	1.88460494
74	Abnormal urine output (HP:0012590)	1.86868109
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.86161799
76	Respiratory failure (HP:0002878)	1.85126016
77	Hyperglycinuria (HP:0003108)	1.84486006
78	Abnormality of the pons (HP:0007361)	1.83724540
79	Decreased central vision (HP:0007663)	1.83706233
80	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.82756419
81	Pallor (HP:0000980)	1.80304068
82	Generalized aminoaciduria (HP:0002909)	1.79869657
83	Congenital primary aphakia (HP:0007707)	1.78380433
84	Aplasia/Hypoplasia of the patella (HP:0006498)	1.78023548
85	Retinal dysplasia (HP:0007973)	1.77756330
86	Constricted visual fields (HP:0001133)	1.77685741
87	Gait imbalance (HP:0002141)	1.75289491
88	Protruding tongue (HP:0010808)	1.75203299
89	Abnormality of the prostate (HP:0008775)	1.73771075
90	Exercise intolerance (HP:0003546)	1.73709950
91	Ketoacidosis (HP:0001993)	1.73606775
92	Abnormality of T cell physiology (HP:0011840)	1.73213189
93	Cerebral palsy (HP:0100021)	1.69977901
94	Patellar aplasia (HP:0006443)	1.69787070
95	Severe muscular hypotonia (HP:0006829)	1.68147839
96	Abnormality of urine glucose concentration (HP:0011016)	1.67774271
97	Glycosuria (HP:0003076)	1.67774271
98	Bulbous nose (HP:0000414)	1.65882510
99	Autoimmune thrombocytopenia (HP:0001973)	1.65703656
100	Hyperalaninemia (HP:0003348)	1.64506952

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.44355238
2	ZAK	3.65613925
3	TLK1	3.60949588
4	TAOK3	3.06562014
5	VRK2	2.93076020
6	ADRBK2	2.73223610
7	FRK	2.70230858
8	GRK1	2.51687198
9	NUAK1	2.24514011
10	MAP4K2	2.20862835
11	BCKDK	1.91827000
12	VRK1	1.91083596
13	TXK	1.88245214
14	MAP4K1	1.81683006
15	BMPR1B	1.78744473
16	DAPK2	1.69875564
17	ACVR1B	1.54984546
18	TIE1	1.54806767
19	MAPKAPK3	1.40227086
20	RPS6KA5	1.36235201
21	WNK3	1.30847232
22	GRK6	1.26787589
23	DYRK2	1.25578771
24	WNK4	1.22855975
25	CAMKK2	1.22657629
26	KIT	1.21579484
27	MAP3K11	1.18085162
28	IKBKB	1.17199861
29	TNK2	1.13602089
30	MARK3	1.07755939
31	BRSK2	1.06263320
32	SYK	1.05550813
33	OXSR1	1.02788291
34	TESK2	1.01135659
35	NME1	0.99756279
36	ITK	0.98085719
37	INSRR	0.97433728
38	PASK	0.96921881
39	SRPK1	0.94889147
40	HIPK2	0.94550802
41	STK16	0.90683467
42	OBSCN	0.90305403
43	PRKCQ	0.88801627
44	TAF1	0.88631358
45	CDC7	0.87014795
46	MAP2K2	0.86519326
47	NME2	0.85386412
48	MAPK11	0.84169318
49	MAPKAPK5	0.83978970
50	PHKG1	0.82038242
51	PHKG2	0.82038242
52	CAMKK1	0.78031290
53	RPS6KA6	0.77707508
54	MAPK13	0.76769029
55	FES	0.75833486
56	STK11	0.74474460
57	SIK2	0.73262552
58	DAPK3	0.72332618
59	MAP2K6	0.72330272
60	BTK	0.70319361
61	ADRBK1	0.70074340
62	ATR	0.68763246
63	CHEK2	0.66100831
64	CSNK1G3	0.64896124
65	MATK	0.62363810
66	PIM1	0.62295511
67	TYK2	0.60703633
68	CAMK1	0.60581200
69	STK39	0.60175990
70	KDR	0.60037839
71	RPS6KC1	0.58561102
72	RPS6KL1	0.58561102
73	LYN	0.56951709
74	TGFBR1	0.56226096
75	ABL2	0.55218590
76	DAPK1	0.55035053
77	TRIM28	0.54907131
78	CSNK1G2	0.54613737
79	NEK2	0.52950378
80	CSNK1A1	0.50791747
81	TEC	0.50030093
82	IRAK1	0.49993098
83	CAMK4	0.49620611
84	CDK8	0.48834495
85	CAMK1D	0.48493531
86	RPS6KB2	0.46855710
87	PRKCI	0.45405871
88	PIM2	0.45346442
89	PRKCG	0.45318161
90	PRKAA1	0.41226230
91	MUSK	0.41121000
92	PIK3CA	0.40829552
93	PKN1	0.40448651
94	PRKACA	0.39745440
95	AURKA	0.39516711
96	PRKAA2	0.39091250
97	NLK	0.38435162
98	MAP3K7	0.37194439
99	IRAK2	0.36895949
100	MAP3K4	0.36817949

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.41323928
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.10955920
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.68892214
4	Parkinsons disease_Homo sapiens_hsa05012	2.61752826
5	Phototransduction_Homo sapiens_hsa04744	2.20653735
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.10575503
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.09528630
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07230667
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.99717742
10	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.99226964
11	RNA polymerase_Homo sapiens_hsa03020	1.97655466
12	Sulfur relay system_Homo sapiens_hsa04122	1.96004571
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.83550321
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.82847582
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.80873977
16	Homologous recombination_Homo sapiens_hsa03440	1.78131743
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.75478401
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.71765507
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.70466967
20	Asthma_Homo sapiens_hsa05310	1.68037639
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.64939488
22	Huntingtons disease_Homo sapiens_hsa05016	1.62131259
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55249344
24	Base excision repair_Homo sapiens_hsa03410	1.53523730
25	Alzheimers disease_Homo sapiens_hsa05010	1.53448546
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.50442409
27	One carbon pool by folate_Homo sapiens_hsa00670	1.50415941
28	Butanoate metabolism_Homo sapiens_hsa00650	1.46117932
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42503685
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38319089
31	RNA degradation_Homo sapiens_hsa03018	1.34175263
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30436896
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29616269
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.28310033
35	Allograft rejection_Homo sapiens_hsa05330	1.27889909
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.27222485
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26833996
38	Peroxisome_Homo sapiens_hsa04146	1.26416942
39	Caffeine metabolism_Homo sapiens_hsa00232	1.25806579
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25431997
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.24077682
42	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.23208107
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23107119
44	DNA replication_Homo sapiens_hsa03030	1.21295968
45	Graft-versus-host disease_Homo sapiens_hsa05332	1.17315452
46	Folate biosynthesis_Homo sapiens_hsa00790	1.13233373
47	Basal transcription factors_Homo sapiens_hsa03022	1.10193162
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.04344504
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03564178
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02755925
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99574354
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96980012
53	Regulation of autophagy_Homo sapiens_hsa04140	0.95929318
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95413955
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93014280
56	Proteasome_Homo sapiens_hsa03050	0.92950379
57	Purine metabolism_Homo sapiens_hsa00230	0.92804779
58	Protein export_Homo sapiens_hsa03060	0.92529591
59	Fatty acid degradation_Homo sapiens_hsa00071	0.90783701
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.90653208
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.88967344
62	Metabolic pathways_Homo sapiens_hsa01100	0.82272098
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82190301
64	Alcoholism_Homo sapiens_hsa05034	0.80066602
65	Mismatch repair_Homo sapiens_hsa03430	0.78554979
66	Retinol metabolism_Homo sapiens_hsa00830	0.76297033
67	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.75411742
68	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75380519
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68827167
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.67598513
71	Propanoate metabolism_Homo sapiens_hsa00640	0.66977233
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66027016
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65047924
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62200812
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56686549
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55472473
77	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53674043
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51907761
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51302671
80	Spliceosome_Homo sapiens_hsa03040	0.50157525
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49284877
82	Fatty acid elongation_Homo sapiens_hsa00062	0.48702891
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.45959773
84	ABC transporters_Homo sapiens_hsa02010	0.45427653
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44582955
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43938623
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.43514585
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43220962
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.42682490
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.41112526
91	Sulfur metabolism_Homo sapiens_hsa00920	0.38182919
92	Histidine metabolism_Homo sapiens_hsa00340	0.35929450
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35625267
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35475075
95	Antigen processing and presentation_Homo sapiens_hsa04612	0.35115097
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.34722544
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34549442
98	Olfactory transduction_Homo sapiens_hsa04740	0.32885423
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.31881765
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29897401

ZNF747

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »