ZNF750

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.64586522
2epidermal cell differentiation (GO:0009913)9.28198391
3hair cycle (GO:0042633)9.22981083
4molting cycle (GO:0042303)9.22981083
5keratinocyte proliferation (GO:0043616)9.13546654
6water homeostasis (GO:0030104)8.65039558
7bundle of His cell to Purkinje myocyte communication (GO:0086069)8.32748341
8* epidermis development (GO:0008544)7.56286113
9long-chain fatty acid biosynthetic process (GO:0042759)7.23068749
10intermediate filament organization (GO:0045109)6.43947516
11linoleic acid metabolic process (GO:0043651)5.98838428
12lipoxygenase pathway (GO:0019372)5.86648080
13hemidesmosome assembly (GO:0031581)5.80347184
14phosphatidylserine acyl-chain remodeling (GO:0036150)5.55816089
15phosphatidylinositol acyl-chain remodeling (GO:0036149)5.52421382
16establishment of tissue polarity (GO:0007164)5.45188056
17establishment of planar polarity (GO:0001736)5.45188056
18keratinocyte development (GO:0003334)5.28919616
19intermediate filament cytoskeleton organization (GO:0045104)5.02618673
20intermediate filament-based process (GO:0045103)4.90456617
21skin morphogenesis (GO:0043589)4.86098762
22ectoderm development (GO:0007398)4.85438584
23detection of bacterium (GO:0016045)4.60435501
24polarized epithelial cell differentiation (GO:0030859)4.54042343
25lateral sprouting from an epithelium (GO:0060601)4.47217581
26phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.47062351
27intestinal epithelial cell development (GO:0060576)4.41849783
28gap junction assembly (GO:0016264)4.32015164
29regulation of keratinocyte differentiation (GO:0045616)4.15974672
30hair follicle morphogenesis (GO:0031069)4.14670070
31detection of other organism (GO:0098543)4.09557681
32negative regulation of keratinocyte proliferation (GO:0010839)4.09121616
33surfactant homeostasis (GO:0043129)4.07169015
34phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.04565600
35epithelial cell differentiation involved in prostate gland development (GO:0060742)3.98638646
36positive regulation of epidermal cell differentiation (GO:0045606)3.98546792
37phosphatidylcholine acyl-chain remodeling (GO:0036151)3.87706140
38negative regulation of interferon-gamma production (GO:0032689)3.86929477
39* epithelium development (GO:0060429)3.71513399
40positive regulation of epidermis development (GO:0045684)3.70507902
41regulation of natural killer cell differentiation (GO:0032823)3.68303482
42one-carbon compound transport (GO:0019755)3.57337100
43planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49095067
44regulation of keratinocyte proliferation (GO:0010837)3.48420164
45phosphatidylserine metabolic process (GO:0006658)3.44122394
46chemical homeostasis within a tissue (GO:0048875)3.43620087
47eyelid development in camera-type eye (GO:0061029)3.38441638
48regulation of epidermis development (GO:0045682)3.36390260
49regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.33712695
50ventricular cardiac muscle cell action potential (GO:0086005)3.32025280
51positive regulation of keratinocyte differentiation (GO:0045618)3.29712454
52fatty acid elongation (GO:0030497)3.26838765
53ceramide biosynthetic process (GO:0046513)3.22624453
54regulation of epidermal cell differentiation (GO:0045604)3.18627854
55hair cycle process (GO:0022405)3.14141673
56molting cycle process (GO:0022404)3.14141673
57keratinization (GO:0031424)20.9162576
58atrioventricular valve morphogenesis (GO:0003181)2.86242341
59epithelial cell differentiation (GO:0030855)2.84746443
60epithelial cell-cell adhesion (GO:0090136)2.83671440
61alditol phosphate metabolic process (GO:0052646)2.81443637
62phospholipid catabolic process (GO:0009395)2.79689937
63negative regulation of epidermis development (GO:0045683)2.78427312
64negative regulation of epidermal cell differentiation (GO:0045605)2.78248445
65regulation of heart rate by cardiac conduction (GO:0086091)2.77034593
66positive regulation of monocyte chemotaxis (GO:0090026)2.76340529
67regulation of ruffle assembly (GO:1900027)2.73313835
68skin development (GO:0043588)2.69647234
69polyol transport (GO:0015791)2.64225126
70cell communication involved in cardiac conduction (GO:0086065)2.60216598
71apical protein localization (GO:0045176)2.56215339
72primary alcohol catabolic process (GO:0034310)2.55008763
73transepithelial transport (GO:0070633)2.43874959
74hair cell differentiation (GO:0035315)2.43696072
75genitalia morphogenesis (GO:0035112)2.43269395
76mitotic G1 DNA damage checkpoint (GO:0031571)2.43107919
77sphingolipid biosynthetic process (GO:0030148)2.42147329
78morphogenesis of embryonic epithelium (GO:0016331)2.37940284
79epithelial cell fate commitment (GO:0072148)2.37892175
80regulation of cardioblast differentiation (GO:0051890)2.35071117
81epithelial cell proliferation (GO:0050673)2.34257196
82hair follicle development (GO:0001942)2.34008198
83cellular response to antibiotic (GO:0071236)2.32973483
84cell-cell junction assembly (GO:0007043)2.32091679
85mitotic G1/S transition checkpoint (GO:0044819)2.30961160
86retinol metabolic process (GO:0042572)2.30123867
87sequestering of metal ion (GO:0051238)2.30046156
88Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.29426485
89regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.28188731
90response to phenylpropanoid (GO:0080184)2.27600293
91cardiac conduction (GO:0061337)2.26395291
92G1 DNA damage checkpoint (GO:0044783)2.25831304
93regulation of establishment of planar polarity (GO:0090175)2.25266284
94phosphatidylglycerol metabolic process (GO:0046471)2.24530723
95regulation of hair cycle (GO:0042634)2.24501025
96establishment of skin barrier (GO:0061436)17.9211082
97regulation of water loss via skin (GO:0033561)15.5465700
98desmosome organization (GO:0002934)14.1787069
99keratinocyte differentiation (GO:0030216)11.7125316
100multicellular organismal water homeostasis (GO:0050891)10.4522838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.47560539
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.86572360
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.80368160
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.74285723
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.74081174
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.59411067
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.29627713
8SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.26784259
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.26784259
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.19513869
11* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.18346909
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08744113
13* TP63_23658742_ChIP-Seq_EP156T_Human2.07137398
14TP63_17297297_ChIP-ChIP_HaCaT_Human12.2071266
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.95796928
16* TP63_22573176_ChIP-Seq_HFKS_Human1.85311032
17RXR_22108803_ChIP-Seq_LS180_Human1.83203656
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79608649
19AHR_22903824_ChIP-Seq_MCF-7_Human1.75643777
20* RUNX1_27514584_Chip-Seq_MCF-7_Human1.70258441
21ZNF263_19887448_ChIP-Seq_K562_Human1.57569917
22* KLF5_25053715_ChIP-Seq_YYC3_Human1.56493359
23GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.55808088
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55285748
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52385380
26* GATA3_24758297_ChIP-Seq_MCF-7_Human1.49198933
27* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44236042
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43803135
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.42810036
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38189967
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.38118032
32GATA6_21074721_ChIP-Seq_CACO-2_Human1.36596101
33RACK7_27058665_Chip-Seq_MCF-7_Human1.35106218
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31099747
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29560279
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29041703
37SOX2_20726797_ChIP-Seq_SW620_Human1.26799474
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.25476400
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24837234
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22590242
41FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20493110
42TP53_18474530_ChIP-ChIP_U2OS_Human1.17759937
43* CTCF_27219007_Chip-Seq_Bcells_Human1.17704095
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17046595
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14091053
46CJUN_26792858_Chip-Seq_BT549_Human1.13076342
47AR_21572438_ChIP-Seq_LNCaP_Human1.13073514
48FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12172321
49ERG_20517297_ChIP-Seq_VCAP_Human1.08918621
50GATA4_25053715_ChIP-Seq_YYC3_Human1.08281664
51GATA6_25053715_ChIP-Seq_YYC3_Human1.07216685
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.06680100
53SMC4_20622854_ChIP-Seq_HELA_Human1.06026071
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05728002
55ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05199111
56BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03223333
57* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02651108
58* ATF3_27146783_Chip-Seq_COLON_Human0.98852301
59RBPJ_21746931_ChIP-Seq_IB4_Human0.94907322
60* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94146782
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93462388
62P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92595920
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90907791
64EGR1_19032775_ChIP-ChIP_M12_Human0.90342807
65HNFA_21074721_ChIP-Seq_CACO-2_Human0.90061802
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86708604
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85695194
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82438515
69E2F1_20622854_ChIP-Seq_HELA_Human0.82228267
70SMAD3_21741376_ChIP-Seq_HESCs_Human0.82103463
71FOXA1_25552417_ChIP-Seq_VCAP_Human0.79905581
72CTCF_20526341_ChIP-Seq_ESCs_Human0.78828293
73BCOR_27268052_Chip-Seq_Bcells_Human0.78086557
74ETV1_20927104_ChIP-Seq_GIST48_Human0.75947160
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75507505
76CBX2_22325352_ChIP-Seq_293T-Rex_Human0.73991534
77TCF4_22108803_ChIP-Seq_LS180_Human0.73450233
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73420009
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73420009
80DNAJC2_21179169_ChIP-ChIP_NT2_Human0.71905900
81SUZ12_27294783_Chip-Seq_ESCs_Mouse0.71411640
82CEBPB_22108803_ChIP-Seq_LS180_Human0.70998901
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.70553020
84VDR_22108803_ChIP-Seq_LS180_Human0.70128633
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70063524
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.69990699
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.69964200
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69614395
89TBL1_22424771_ChIP-Seq_293T_Human0.69332033
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69238093
91P53_21459846_ChIP-Seq_SAOS-2_Human0.69041090
92OCT1_27270436_Chip-Seq_PROSTATE_Human0.68428410
93BCAT_22108803_ChIP-Seq_LS180_Human0.67493909
94FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.67080355
95RNF2_27304074_Chip-Seq_ESCs_Mouse0.64537899
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.64535177
97PHF8_20622853_ChIP-Seq_HELA_Human0.63886824
98CREB1_26743006_Chip-Seq_LNCaP_Human0.62338994
99SA1_27219007_Chip-Seq_ERYTHROID_Human0.61735158
100AR_25329375_ChIP-Seq_VCAP_Human0.61289192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.15470409
2MP0005275_abnormal_skin_tensile6.41174292
3MP0010234_abnormal_vibrissa_follicle6.07297100
4MP0000579_abnormal_nail_morphology5.33207932
5MP0005501_abnormal_skin_physiology5.14590544
6MP0010678_abnormal_skin_adnexa3.28839866
7MP0003453_abnormal_keratinocyte_physiol3.28016210
8MP0001216_abnormal_epidermal_layer3.24975009
9MP0000383_abnormal_hair_follicle3.16104767
10MP0002098_abnormal_vibrissa_morphology3.09615285
11MP0000566_synostosis2.84153106
12MP0010771_integument_phenotype2.80099482
13MP0003941_abnormal_skin_development2.78996258
14MP0009379_abnormal_foot_pigmentation2.72802423
15MP0004381_abnormal_hair_follicle2.62394093
16MP0002060_abnormal_skin_morphology2.55663732
17MP0000377_abnormal_hair_follicle2.42533666
18MP0000647_abnormal_sebaceous_gland2.38032298
19MP0005377_hearing/vestibular/ear_phenot2.36365778
20MP0003878_abnormal_ear_physiology2.36365778
21MP0000467_abnormal_esophagus_morphology2.25050635
22MP0004947_skin_inflammation2.19914848
23MP0003705_abnormal_hypodermis_morpholog2.08293277
24MP0004782_abnormal_surfactant_physiolog2.06827117
25MP0004885_abnormal_endolymph1.97757423
26MP0004264_abnormal_extraembryonic_tissu1.97656643
27MP0001188_hyperpigmentation1.83145474
28MP0000427_abnormal_hair_cycle1.83093740
29MP0005409_darkened_coat_color1.74052877
30MP0009931_abnormal_skin_appearance1.67878828
31MP0002095_abnormal_skin_pigmentation1.61816896
32MP0000762_abnormal_tongue_morphology1.57105001
33MP0000367_abnormal_coat/_hair1.40156241
34MP0004043_abnormal_pH_regulation1.38158603
35MP0003566_abnormal_cell_adhesion1.26184638
36MP0003191_abnormal_cellular_cholesterol1.25176495
37MP0001191_abnormal_skin_condition1.21218202
38MP0000465_gastrointestinal_hemorrhage1.20287120
39MP0003011_delayed_dark_adaptation1.08845893
40MP0010352_gastrointestinal_tract_polyps1.07664264
41MP0001243_abnormal_dermal_layer1.05811828
42MP0009780_abnormal_chondrocyte_physiolo0.84595486
43MP0005023_abnormal_wound_healing0.82268723
44MP0001784_abnormal_fluid_regulation0.81703356
45MP0010030_abnormal_orbit_morphology0.81457292
46MP0002234_abnormal_pharynx_morphology0.78988312
47MP0001851_eye_inflammation0.77482520
48MP0009053_abnormal_anal_canal0.74213390
49MP0002009_preneoplasia0.68730957
50MP0008789_abnormal_olfactory_epithelium0.68387624
51MP0008004_abnormal_stomach_pH0.66564377
52MP0005174_abnormal_tail_pigmentation0.55594137
53MP0002177_abnormal_outer_ear0.55539965
54MP0000015_abnormal_ear_pigmentation0.54822118
55MP0001340_abnormal_eyelid_morphology0.53332198
56MP0000627_abnormal_mammary_gland0.53185174
57MP0004185_abnormal_adipocyte_glucose0.52717569
58MP0002249_abnormal_larynx_morphology0.50903838
59MP0005076_abnormal_cell_differentiation0.49807513
60MP0005499_abnormal_olfactory_system0.49413487
61MP0005394_taste/olfaction_phenotype0.49413487
62MP0005075_abnormal_melanosome_morpholog0.48653289
63MP0002111_abnormal_tail_morphology0.48213541
64MP0008961_abnormal_basal_metabolism0.44810429
65MP0001984_abnormal_olfaction0.41602414
66MP0003755_abnormal_palate_morphology0.40274419
67MP0003950_abnormal_plasma_membrane0.39301972
68MP0002282_abnormal_trachea_morphology0.37967550
69MP0003638_abnormal_response/metabolism_0.37692810
70MP0005503_abnormal_tendon_morphology0.34385879
71MP0001485_abnormal_pinna_reflex0.34341750
72MP0002653_abnormal_ependyma_morphology0.33448108
73MP0000470_abnormal_stomach_morphology0.31007616
74MP0002233_abnormal_nose_morphology0.30755496
75MP0001765_abnormal_ion_homeostasis0.28190580
76MP0003763_abnormal_thymus_physiology0.28156027
77MP0000678_abnormal_parathyroid_gland0.27326559
78MP0003315_abnormal_perineum_morphology0.25370242
79MP0008995_early_reproductive_senescence0.24025651
80MP0002133_abnormal_respiratory_system0.22948837
81MP0005388_respiratory_system_phenotype0.22948837
82MP0000432_abnormal_head_morphology0.22254371
83MP0004019_abnormal_vitamin_homeostasis0.22158185
84MP0002006_tumorigenesis0.21952053
85MP0004197_abnormal_fetal_growth/weight/0.20681788
86MP0005666_abnormal_adipose_tissue0.20599268
87MP0002166_altered_tumor_susceptibility0.19855058
88MP0005375_adipose_tissue_phenotype0.16843969
89MP0001186_pigmentation_phenotype0.16087509
90MP0003045_fibrosis0.14419955
91MP0000462_abnormal_digestive_system0.13492139
92MP0001177_atelectasis0.13320277
93MP0005647_abnormal_sex_gland0.13093978
94MP0001502_abnormal_circadian_rhythm0.13091261
95MP0001346_abnormal_lacrimal_gland0.11821710
96MP0001756_abnormal_urination0.11558216
97MP0002109_abnormal_limb_morphology0.10889507
98MP0000613_abnormal_salivary_gland0.10476333
99MP0003828_pulmonary_edema0.09695888
100MP0006138_congestive_heart_failure0.09356976

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.49199338
2Palmoplantar hyperkeratosis (HP:0000972)7.97421506
3Increased IgE level (HP:0003212)7.80910311
4Palmar hyperkeratosis (HP:0010765)7.60158885
5Erythroderma (HP:0001019)7.45251393
6Congenital ichthyosiform erythroderma (HP:0007431)7.16612065
7Plantar hyperkeratosis (HP:0007556)6.81270650
8Hypotrichosis (HP:0001006)6.66714126
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.42753063
10Alopecia of scalp (HP:0002293)6.41737725
11Onycholysis (HP:0001806)6.20384872
12Abnormality of the axillary hair (HP:0100134)5.78540882
13Abnormality of secondary sexual hair (HP:0009888)5.78540882
14Erythema (HP:0010783)5.66867133
15Oral leukoplakia (HP:0002745)5.64157000
16Thick nail (HP:0001805)5.59051472
17Corneal erosion (HP:0200020)5.22864836
18Woolly hair (HP:0002224)5.19263568
19Right ventricular cardiomyopathy (HP:0011663)5.03656845
20Lip pit (HP:0100267)4.79776478
21Parakeratosis (HP:0001036)4.65239331
22Pili torti (HP:0003777)4.37657313
23Conjunctival hamartoma (HP:0100780)4.06689870
24Fragile nails (HP:0001808)4.05192398
25Absent eyelashes (HP:0000561)3.99008984
26Nail dystrophy (HP:0008404)3.95675364
27Palmoplantar keratoderma (HP:0000982)3.86905503
28Abnormality of the salivary glands (HP:0010286)3.77720705
29Sparse eyelashes (HP:0000653)3.74951412
30Abnormal hair laboratory examination (HP:0003328)3.70826939
31Ectropion (HP:0000656)3.70694556
32Hypohidrosis (HP:0000966)3.68800198
33Sparse scalp hair (HP:0002209)3.36106753
34Abnormal blistering of the skin (HP:0008066)3.33175924
35Gangrene (HP:0100758)3.31986027
36Absent hair (HP:0002298)3.24624315
37Hypoplastic labia majora (HP:0000059)3.05630243
38Hamartoma of the eye (HP:0010568)2.96259036
39Milia (HP:0001056)2.89507310
40Abnormality of the labia majora (HP:0012881)2.81781849
41Abnormality of hair growth rate (HP:0011363)2.70136302
42Slow-growing hair (HP:0002217)2.70136302
43Blepharitis (HP:0000498)2.68161762
44Pruritus (HP:0000989)2.62263120
45Furrowed tongue (HP:0000221)2.58558906
46Natal tooth (HP:0000695)2.43716982
47Brittle hair (HP:0002299)2.35891312
48Ridged nail (HP:0001807)2.33119911
49Abnormality of permanent molar morphology (HP:0011071)2.31419592
50Abnormality of the dental root (HP:0006486)2.31419592
51Taurodontia (HP:0000679)2.31419592
52Advanced eruption of teeth (HP:0006288)2.30606731
53Duplicated collecting system (HP:0000081)2.28691250
54Pustule (HP:0200039)2.24804803
55Oligodontia (HP:0000677)2.24649150
56Nasolacrimal duct obstruction (HP:0000579)2.18960001
57Abnormality of the renal collecting system (HP:0004742)2.17754183
58Abnormality of molar morphology (HP:0011070)2.16371600
59Abnormality of molar (HP:0011077)2.16371600
60Septate vagina (HP:0001153)2.14957401
61Dehydration (HP:0001944)2.11384224
62Abnormality of the dental pulp (HP:0006479)2.10567521
63Split foot (HP:0001839)2.09723148
64Eczematoid dermatitis (HP:0000976)2.09565136
65Follicular hyperkeratosis (HP:0007502)2.09339033
66Amniotic constriction ring (HP:0009775)2.08737020
67Abnormality of placental membranes (HP:0011409)2.08737020
68Melanocytic nevus (HP:0000995)2.08639633
69Acanthosis nigricans (HP:0000956)2.05213776
70Depressed nasal tip (HP:0000437)2.05039092
71Curly hair (HP:0002212)2.03215292
72Selective tooth agenesis (HP:0001592)2.01341132
73Conical tooth (HP:0000698)2.00033914
74Laryngomalacia (HP:0001601)1.97435756
75Lack of skin elasticity (HP:0100679)1.93705717
76Popliteal pterygium (HP:0009756)1.88780406
77Labial hypoplasia (HP:0000066)1.86066949
78Recurrent corneal erosions (HP:0000495)1.85985405
79Fine hair (HP:0002213)1.83860862
80Autoamputation (HP:0001218)1.82996703
81Abnormality of the lacrimal duct (HP:0011481)1.80273734
82Anonychia (HP:0001798)1.79274297
83Hypergammaglobulinemia (HP:0010702)1.72993472
84Chronic bronchitis (HP:0004469)1.71747314
85Xerostomia (HP:0000217)1.70821496
86Hamartoma (HP:0010566)1.70788141
87Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69013638
88Hypoplastic female external genitalia (HP:0012815)1.68224953
89Hyperhidrosis (HP:0000975)1.63081661
90Aplasia involving bones of the extremities (HP:0009825)1.61843859
91Aplasia involving bones of the upper limbs (HP:0009823)1.61843859
92Aplasia of the phalanges of the hand (HP:0009802)1.61843859
93Dry hair (HP:0011359)1.60284672
94Multifactorial inheritance (HP:0001426)1.57717636
95Abnormality of the nasolacrimal system (HP:0000614)1.57247768
96Ventricular tachycardia (HP:0004756)1.55988925
97Hyperactive renin-angiotensin system (HP:0000841)1.55053847
98Hyperkalemia (HP:0002153)1.54640773
99Breast hypoplasia (HP:0003187)1.53025584
100Dry skin (HP:0000958)1.52112486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.79679448
2MAPKAPK34.69490031
3TGFBR14.12071809
4MAP3K63.48172184
5MST1R3.42042964
6FER3.20029874
7STK243.00171694
8CDK122.79377973
9MAP3K22.67700122
10EEF2K2.54587575
11LATS12.30436990
12FGFR12.22885766
13RIPK12.10693565
14MST41.88363494
15MAP3K31.81190090
16MET1.80837134
17STK38L1.69628795
18TRPM71.64590123
19RPS6KB21.60571899
20NME11.59487078
21FGFR31.59247358
22BCKDK1.56889813
23MAP3K71.53359278
24MAPK151.47986294
25PBK1.33279215
26MARK21.30820399
27SGK2231.22245519
28SGK4941.22245519
29AKT31.19474345
30MAP3K91.13684874
31SIK11.13075377
32LATS21.09455975
33STK391.00646672
34MAP2K61.00501029
35STK380.99507874
36GRK60.95215201
37EPHA30.92988401
38MAPK70.90146456
39EIF2AK30.89433569
40FRK0.86906011
41BCR0.85918192
42INSRR0.85324128
43MAPKAPK50.83578013
44SGK20.81923734
45IKBKB0.81710898
46CAMK1D0.80481852
47WNK10.79841406
48PRKAA20.77361911
49BRD40.76274300
50MTOR0.76036186
51STK30.75787524
52RPS6KB10.75416735
53PRKD20.71346583
54ICK0.69769337
55MAPKAPK20.67876129
56FGFR20.67814861
57TRIB30.66572671
58ERBB30.65622916
59PTK20.63550862
60SGK30.62143326
61NEK60.61779997
62SMG10.59395370
63CAMK1G0.59356426
64ERN10.58839293
65PIK3CG0.55498667
66EPHB10.53767366
67MAPK120.52488651
68WNK40.49140858
69SGK10.45476094
70ERBB20.45359870
71PDK20.43345207
72RPS6KA20.43098538
73TAOK10.41949352
74ADRBK10.41523196
75IRAK10.40184116
76LRRK20.39313534
77PRKCE0.38684231
78CHUK0.38497741
79TESK10.38103572
80TLK10.36437196
81CDC42BPA0.36145579
82MAP2K40.35210413
83TYRO30.35038588
84ABL10.35013892
85PIM20.34968728
86PRKCI0.33738840
87BRSK20.31274189
88PDGFRB0.30816996
89CDK70.29687308
90NLK0.28647841
91MAP3K10.27634204
92OXSR10.24282288
93DMPK0.23394277
94PRKCD0.20486045
95EPHB20.19981419
96PRKD10.19488085
97CAMK40.19222055
98MAP2K10.17900039
99HIPK20.17811104
100TGFBR20.17729500

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.18790869
2Linoleic acid metabolism_Homo sapiens_hsa005914.94784705
3Ether lipid metabolism_Homo sapiens_hsa005653.46814532
4Arachidonic acid metabolism_Homo sapiens_hsa005903.09081249
5Sphingolipid metabolism_Homo sapiens_hsa006002.43350564
6Histidine metabolism_Homo sapiens_hsa003402.34037304
7Ovarian steroidogenesis_Homo sapiens_hsa049132.19296804
8Phototransduction_Homo sapiens_hsa047442.12942597
9Circadian rhythm_Homo sapiens_hsa047102.09393050
10GnRH signaling pathway_Homo sapiens_hsa049122.06524678
11Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.91028682
12VEGF signaling pathway_Homo sapiens_hsa043701.66412828
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66235525
14Glycerophospholipid metabolism_Homo sapiens_hsa005641.62774722
15Long-term depression_Homo sapiens_hsa047301.51823245
16Choline metabolism in cancer_Homo sapiens_hsa052311.45220661
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.42523356
18Dorso-ventral axis formation_Homo sapiens_hsa043201.37402814
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37334501
20Phenylalanine metabolism_Homo sapiens_hsa003601.36282159
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34914987
22Serotonergic synapse_Homo sapiens_hsa047261.34674322
23Notch signaling pathway_Homo sapiens_hsa043301.27684733
24Renin secretion_Homo sapiens_hsa049241.27283818
25Amoebiasis_Homo sapiens_hsa051461.26476502
26Salivary secretion_Homo sapiens_hsa049701.23815042
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23010820
28ECM-receptor interaction_Homo sapiens_hsa045121.14199101
29Adherens junction_Homo sapiens_hsa045201.14096811
30Ras signaling pathway_Homo sapiens_hsa040141.09477761
31ABC transporters_Homo sapiens_hsa020101.04596053
32Retinol metabolism_Homo sapiens_hsa008301.04286002
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02002813
34Tight junction_Homo sapiens_hsa045300.91691578
35Gastric acid secretion_Homo sapiens_hsa049710.90542733
36Fatty acid elongation_Homo sapiens_hsa000620.88342932
37Melanogenesis_Homo sapiens_hsa049160.86902221
38Sphingolipid signaling pathway_Homo sapiens_hsa040710.85629963
39Acute myeloid leukemia_Homo sapiens_hsa052210.82526414
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.81752587
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81345588
42p53 signaling pathway_Homo sapiens_hsa041150.81340801
43beta-Alanine metabolism_Homo sapiens_hsa004100.78173657
44Hedgehog signaling pathway_Homo sapiens_hsa043400.77230794
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76403966
46Axon guidance_Homo sapiens_hsa043600.76237345
47Tyrosine metabolism_Homo sapiens_hsa003500.75309887
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74439748
49MicroRNAs in cancer_Homo sapiens_hsa052060.74340706
50Thyroid cancer_Homo sapiens_hsa052160.72278511
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71907503
52Inositol phosphate metabolism_Homo sapiens_hsa005620.71841316
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71454407
54Glioma_Homo sapiens_hsa052140.70526974
55Oxytocin signaling pathway_Homo sapiens_hsa049210.70142397
56Hippo signaling pathway_Homo sapiens_hsa043900.69073942
57Estrogen signaling pathway_Homo sapiens_hsa049150.68800120
58Basal cell carcinoma_Homo sapiens_hsa052170.68684229
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.68285242
60Bladder cancer_Homo sapiens_hsa052190.66718587
61Glutamatergic synapse_Homo sapiens_hsa047240.60645984
62Platelet activation_Homo sapiens_hsa046110.59570448
63Staphylococcus aureus infection_Homo sapiens_hsa051500.59130703
64Long-term potentiation_Homo sapiens_hsa047200.56820048
65Pancreatic secretion_Homo sapiens_hsa049720.56603117
66Endocytosis_Homo sapiens_hsa041440.56217486
67ErbB signaling pathway_Homo sapiens_hsa040120.53969436
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53774662
69Hepatitis C_Homo sapiens_hsa051600.53116754
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.52928979
71Olfactory transduction_Homo sapiens_hsa047400.52540231
72Small cell lung cancer_Homo sapiens_hsa052220.51788206
73Insulin signaling pathway_Homo sapiens_hsa049100.50898542
74Chemical carcinogenesis_Homo sapiens_hsa052040.49982913
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.49449538
76Glucagon signaling pathway_Homo sapiens_hsa049220.49017789
77cAMP signaling pathway_Homo sapiens_hsa040240.48928378
78PPAR signaling pathway_Homo sapiens_hsa033200.47762616
79Fatty acid biosynthesis_Homo sapiens_hsa000610.46780966
80Calcium signaling pathway_Homo sapiens_hsa040200.46705041
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46428940
82Collecting duct acid secretion_Homo sapiens_hsa049660.45011130
83MAPK signaling pathway_Homo sapiens_hsa040100.44390726
84Circadian entrainment_Homo sapiens_hsa047130.43906903
85Rap1 signaling pathway_Homo sapiens_hsa040150.43857250
86Pathways in cancer_Homo sapiens_hsa052000.42979360
87Mineral absorption_Homo sapiens_hsa049780.42954759
88Proteoglycans in cancer_Homo sapiens_hsa052050.38939508
89Renal cell carcinoma_Homo sapiens_hsa052110.35764477
90Oocyte meiosis_Homo sapiens_hsa041140.34829728
91Protein digestion and absorption_Homo sapiens_hsa049740.34531512
92Lysine degradation_Homo sapiens_hsa003100.33134852
93TGF-beta signaling pathway_Homo sapiens_hsa043500.32633525
94Pertussis_Homo sapiens_hsa051330.32330866
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31659447
96Taste transduction_Homo sapiens_hsa047420.31541412
97Glycerolipid metabolism_Homo sapiens_hsa005610.29744506
98Wnt signaling pathway_Homo sapiens_hsa043100.29208801
99Amphetamine addiction_Homo sapiens_hsa050310.28673507
100Fat digestion and absorption_Homo sapiens_hsa049750.28644217

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