ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	melanin biosynthetic process (GO:0042438)	9.60118220
2	melanin metabolic process (GO:0006582)	9.14080373
3	secondary metabolite biosynthetic process (GO:0044550)	8.46100919
4	meiotic chromosome segregation (GO:0045132)	6.40567813
5	gene silencing by RNA (GO:0031047)	5.93687838
6	keratinization (GO:0031424)	5.87211026
7	platelet dense granule organization (GO:0060155)	5.65143279
8	resolution of meiotic recombination intermediates (GO:0000712)	5.05755980
9	male meiosis (GO:0007140)	4.95859633
10	gonadal mesoderm development (GO:0007506)	4.48376413
11	melanocyte differentiation (GO:0030318)	4.45458457
12	lipid translocation (GO:0034204)	4.43908264
13	phospholipid translocation (GO:0045332)	4.43908264
14	establishment of skin barrier (GO:0061436)	4.42084275
15	regulation of DNA endoreduplication (GO:0032875)	4.33979890
16	reciprocal DNA recombination (GO:0035825)	4.30282026
17	reciprocal meiotic recombination (GO:0007131)	4.30282026
18	lactate metabolic process (GO:0006089)	4.29261209
19	pigment cell differentiation (GO:0050931)	4.28644846
20	lung-associated mesenchyme development (GO:0060484)	4.12757146
21	neuroepithelial cell differentiation (GO:0060563)	4.12511874
22	protein K11-linked deubiquitination (GO:0035871)	4.12212026
23	keratinocyte development (GO:0003334)	4.07657220
24	DNA alkylation (GO:0006305)	3.95020568
25	DNA methylation (GO:0006306)	3.95020568
26	regulation of protein polyubiquitination (GO:1902914)	3.90812154
27	meiotic cell cycle (GO:0051321)	3.90639080
28	phenol-containing compound biosynthetic process (GO:0046189)	3.88169983
29	synapsis (GO:0007129)	3.86465082
30	monoubiquitinated protein deubiquitination (GO:0035520)	3.84576001
31	male meiosis I (GO:0007141)	3.83099442
32	negative regulation of keratinocyte proliferation (GO:0010839)	3.82412304
33	Golgi to endosome transport (GO:0006895)	3.75377126
34	endosome to pigment granule transport (GO:0043485)	3.73406825
35	endosome to melanosome transport (GO:0035646)	3.73406825
36	mitotic sister chromatid cohesion (GO:0007064)	3.70441482
37	synaptonemal complex assembly (GO:0007130)	3.68864322
38	establishment of protein localization to Golgi (GO:0072600)	3.67752574
39	myelin assembly (GO:0032288)	3.67371926
40	regulation of water loss via skin (GO:0033561)	3.57850016
41	pigment granule organization (GO:0048753)	3.56244206
42	melanosome organization (GO:0032438)	3.53795642
43	embryonic foregut morphogenesis (GO:0048617)	3.53377356
44	synaptonemal complex organization (GO:0070193)	3.52133682
45	protein K6-linked ubiquitination (GO:0085020)	3.42611724
46	phospholipid homeostasis (GO:0055091)	3.42508516
47	chromosome organization involved in meiosis (GO:0070192)	3.42327140
48	proline transport (GO:0015824)	3.39585690
49	ectoderm development (GO:0007398)	3.37726397
50	prenylation (GO:0097354)	3.37042985
51	protein prenylation (GO:0018342)	3.37042985
52	protein targeting to Golgi (GO:0000042)	3.32671780
53	cilium or flagellum-dependent cell motility (GO:0001539)	3.29418967
54	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.26855719
55	cullin deneddylation (GO:0010388)	3.26579263
56	microtubule anchoring (GO:0034453)	3.26534947
57	regulation of axon regeneration (GO:0048679)	3.25605739
58	regulation of neuron projection regeneration (GO:0070570)	3.25605739
59	auditory receptor cell differentiation (GO:0042491)	3.25138734
60	response to superoxide (GO:0000303)	3.21413422
61	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.15952838
62	establishment of nucleus localization (GO:0040023)	3.15151262
63	DNA methylation or demethylation (GO:0044728)	3.11262175
64	cellular response to oxygen radical (GO:0071450)	3.09772945
65	removal of superoxide radicals (GO:0019430)	3.09772945
66	cellular response to superoxide (GO:0071451)	3.09772945
67	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.04867977
68	meiotic nuclear division (GO:0007126)	3.04325219
69	gene silencing (GO:0016458)	3.02802504
70	response to lipoprotein particle (GO:0055094)	3.02258662
71	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.99888866
72	sister chromatid cohesion (GO:0007062)	2.95069825
73	centriole assembly (GO:0098534)	2.94705225
74	response to oxygen radical (GO:0000305)	2.91860055
75	sympathetic nervous system development (GO:0048485)	2.88962215
76	protein deneddylation (GO:0000338)	2.86888405
77	protein localization to Golgi apparatus (GO:0034067)	2.86437517
78	tyrosine metabolic process (GO:0006570)	2.83777991
79	regulation of keratinocyte proliferation (GO:0010837)	2.83481861
80	negative regulation of activin receptor signaling pathway (GO:0032926)	2.81754904
81	gastrulation with mouth forming second (GO:0001702)	2.80092381
82	pigmentation (GO:0043473)	2.79329981
83	nucleus localization (GO:0051647)	2.76639581
84	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.75184440
85	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.75184440
86	pyrimidine dimer repair (GO:0006290)	2.74349284
87	regulation of membrane lipid distribution (GO:0097035)	2.71224372
88	interkinetic nuclear migration (GO:0022027)	2.70323054
89	nuclear pore complex assembly (GO:0051292)	2.69919479
90	developmental pigmentation (GO:0048066)	2.67968401
91	hair cell differentiation (GO:0035315)	2.67002802
92	meiosis I (GO:0007127)	2.65830110
93	lung secretory cell differentiation (GO:0061140)	2.65107633
94	phospholipid efflux (GO:0033700)	2.64691836
95	meiotic cell cycle process (GO:1903046)	2.60018144
96	secretory granule organization (GO:0033363)	2.59506369
97	centrosome duplication (GO:0051298)	2.58189710
98	nitric oxide biosynthetic process (GO:0006809)	2.55552595
99	piRNA metabolic process (GO:0034587)	14.8386981
100	DNA methylation involved in gamete generation (GO:0043046)	10.5718387

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.67509162
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.80462569
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75454451
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72843518
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.70106256
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.64967950
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.43277172
8	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.41660828
9	FUS_26573619_Chip-Seq_HEK293_Human	2.35354748
10	P300_19829295_ChIP-Seq_ESCs_Human	2.32645976
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.28080792
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.13553311
13	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.10148623
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.09800108
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.00497995
16	TP53_16413492_ChIP-PET_HCT116_Human	1.98279367
17	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.90751153
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.89328190
19	EWS_26573619_Chip-Seq_HEK293_Human	1.86784483
20	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.81986921
21	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.81021154
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.78667242
23	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.77589217
24	STAT3_23295773_ChIP-Seq_U87_Human	1.77049249
25	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.75386121
26	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.74980795
27	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.74936700
28	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.71407085
29	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.70013549
30	TCF4_23295773_ChIP-Seq_U87_Human	1.69543781
31	E2F7_22180533_ChIP-Seq_HELA_Human	1.69386083
32	GATA1_22025678_ChIP-Seq_K562_Human	1.68721317
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.65935496
34	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.65023728
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62839476
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.62211302
37	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.59819491
38	RUNX2_22187159_ChIP-Seq_PCA_Human	1.59553103
39	VDR_22108803_ChIP-Seq_LS180_Human	1.59085542
40	AR_25329375_ChIP-Seq_VCAP_Human	1.58377648
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58331413
42	AHR_22903824_ChIP-Seq_MCF-7_Human	1.58297324
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.55191010
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55044460
45	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.52791646
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52713309
47	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.49904372
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49584826
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.49584826
50	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.46900185
51	TP53_18474530_ChIP-ChIP_U2OS_Human	1.46582372
52	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.46193150
53	CJUN_26792858_Chip-Seq_BT549_Human	1.45768125
54	CDX2_22108803_ChIP-Seq_LS180_Human	1.45237117
55	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.43826800
56	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.43826800
57	TP63_23658742_ChIP-Seq_EP156T_Human	1.43071606
58	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.41791511
59	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.41549285
60	EZH2_22144423_ChIP-Seq_EOC_Human	1.41519291
61	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.41187426
62	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41095702
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.40785850
64	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.39850271
65	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38592103
66	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.37895906
67	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.37656649
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32468332
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.32322376
70	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.30763124
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30577371
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29230300
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29230300
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28881211
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.28856571
76	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.24205143
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23912867
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.23750407
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21693711
80	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21439601
81	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.21075095
82	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.19898372
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19568980
84	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.18962124
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18636889
86	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.17792107
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.17142941
88	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.17120999
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15510014
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.15134222
91	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.14773153
92	JUN_21703547_ChIP-Seq_K562_Human	1.14335353
93	AR_21909140_ChIP-Seq_LNCAP_Human	1.13702583
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12878821
95	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12444892
96	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10017107
97	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09090605
98	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08985435
99	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.08454534
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07087208

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	6.67111094
2	MP0005171_absent_coat_pigmentation	5.04658988
3	MP0003136_yellow_coat_color	4.82841249
4	MP0000015_abnormal_ear_pigmentation	4.70125457
5	MP0000569_abnormal_digit_pigmentation	4.31581828
6	MP0008057_abnormal_DNA_replication	4.06917940
7	MP0008877_abnormal_DNA_methylation	3.82633334
8	MP0002095_abnormal_skin_pigmentation	3.69495201
9	MP0005408_hypopigmentation	3.57150618
10	MP0005174_abnormal_tail_pigmentation	3.33590425
11	MP0005075_abnormal_melanosome_morpholog	3.15725025
12	MP0004381_abnormal_hair_follicle	2.95510708
13	MP0000371_diluted_coat_color	2.73796226
14	MP0002254_reproductive_system_inflammat	2.53076745
15	MP0005409_darkened_coat_color	2.46763126
16	MP0002796_impaired_skin_barrier	2.35981834
17	MP0001324_abnormal_eye_pigmentation	2.17002962
18	MP0002075_abnormal_coat/hair_pigmentati	1.98223256
19	MP0008995_early_reproductive_senescence	1.90281880
20	MP0002877_abnormal_melanocyte_morpholog	1.87713412
21	MP0008058_abnormal_DNA_repair	1.84005782
22	MP0003806_abnormal_nucleotide_metabolis	1.79827241
23	MP0002102_abnormal_ear_morphology	1.77682500
24	MP0002938_white_spotting	1.76483762
25	MP0010678_abnormal_skin_adnexa	1.69383088
26	MP0000383_abnormal_hair_follicle	1.69168944
27	MP0010094_abnormal_chromosome_stability	1.63601560
28	MP0005187_abnormal_penis_morphology	1.58938102
29	MP0001186_pigmentation_phenotype	1.52444583
30	MP0000427_abnormal_hair_cycle	1.52222488
31	MP0003191_abnormal_cellular_cholesterol	1.46677192
32	MP0005257_abnormal_intraocular_pressure	1.39241439
33	MP0005253_abnormal_eye_physiology	1.36838772
34	MP0003890_abnormal_embryonic-extraembry	1.34705155
35	MP0010234_abnormal_vibrissa_follicle	1.34278301
36	MP0003786_premature_aging	1.29288552
37	MP0000647_abnormal_sebaceous_gland	1.28414118
38	MP0005501_abnormal_skin_physiology	1.25780837
39	MP0010352_gastrointestinal_tract_polyps	1.25382689
40	MP0009780_abnormal_chondrocyte_physiolo	1.21590544
41	MP0005248_abnormal_Harderian_gland	1.19657756
42	MP0003718_maternal_effect	1.19003032
43	MP0003453_abnormal_keratinocyte_physiol	1.18344637
44	MP0003878_abnormal_ear_physiology	1.17189665
45	MP0005377_hearing/vestibular/ear_phenot	1.17189665
46	MP0004885_abnormal_endolymph	1.13883484
47	MP0001915_intracranial_hemorrhage	1.10042432
48	MP0000377_abnormal_hair_follicle	1.06636473
49	MP0001929_abnormal_gametogenesis	1.05803541
50	MP0002210_abnormal_sex_determination	1.05651652
51	MP0003941_abnormal_skin_development	1.04757314
52	MP0002638_abnormal_pupillary_reflex	0.99426984
53	MP0005275_abnormal_skin_tensile	0.96832954
54	MP0002090_abnormal_vision	0.89983305
55	MP0006054_spinal_hemorrhage	0.87497716
56	MP0003698_abnormal_male_reproductive	0.87111535
57	MP0005197_abnormal_uvea_morphology	0.83693569
58	MP0008961_abnormal_basal_metabolism	0.82080683
59	MP0001145_abnormal_male_reproductive	0.81941902
60	MP0003950_abnormal_plasma_membrane	0.81848094
61	MP0004019_abnormal_vitamin_homeostasis	0.81786066
62	MP0000653_abnormal_sex_gland	0.80048243
63	MP0009697_abnormal_copulation	0.77175450
64	MP0001191_abnormal_skin_condition	0.76931623
65	MP0001216_abnormal_epidermal_layer	0.75588961
66	MP0003252_abnormal_bile_duct	0.75554554
67	MP0000465_gastrointestinal_hemorrhage	0.69994795
68	MP0002751_abnormal_autonomic_nervous	0.69607749
69	MP0002837_dystrophic_cardiac_calcinosis	0.67882385
70	MP0005551_abnormal_eye_electrophysiolog	0.67790052
71	MP0001188_hyperpigmentation	0.67310911
72	MP0003183_abnormal_peptide_metabolism	0.67033336
73	MP0010771_integument_phenotype	0.66902735
74	MP0001485_abnormal_pinna_reflex	0.65270005
75	MP0000367_abnormal_coat/_hair	0.64671432
76	MP0004197_abnormal_fetal_growth/weight/	0.62454225
77	MP0004145_abnormal_muscle_electrophysio	0.62025039
78	MP0005391_vision/eye_phenotype	0.61822147
79	MP0005085_abnormal_gallbladder_physiolo	0.60097543
80	MP0006072_abnormal_retinal_apoptosis	0.59246023
81	MP0005266_abnormal_metabolism	0.58374719
82	MP0002928_abnormal_bile_duct	0.56341860
83	MP0001984_abnormal_olfaction	0.54818338
84	MP0005167_abnormal_blood-brain_barrier	0.53753388
85	MP0005379_endocrine/exocrine_gland_phen	0.53250658
86	MP0001299_abnormal_eye_distance/	0.52337477
87	MP0003755_abnormal_palate_morphology	0.51305692
88	MP0003935_abnormal_craniofacial_develop	0.49428515
89	MP0000462_abnormal_digestive_system	0.48013005
90	MP0005394_taste/olfaction_phenotype	0.47648414
91	MP0005499_abnormal_olfactory_system	0.47648414
92	MP0002177_abnormal_outer_ear	0.45918135
93	MP0005195_abnormal_posterior_eye	0.43886631
94	MP0001666_abnormal_nutrient_absorption	0.43210921
95	MP0005395_other_phenotype	0.42982817
96	MP0003195_calcinosis	0.42286169
97	MP0003943_abnormal_hepatobiliary_system	0.42125761
98	MP0002139_abnormal_hepatobiliary_system	0.41752923
99	MP0003937_abnormal_limbs/digits/tail_de	0.40373978
100	MP0001879_abnormal_lymphatic_vessel	0.38577558

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.77603986
2	Hypoplasia of the fovea (HP:0007750)	5.77603986
3	Aplasia/Hypoplasia of the macula (HP:0008059)	5.58342380
4	Aplasia/Hypoplasia affecting the retina (HP:0008061)	5.10281914
5	Abnormality of the fovea (HP:0000493)	4.70614668
6	Blue irides (HP:0000635)	4.61285757
7	Papillary thyroid carcinoma (HP:0002895)	4.54391573
8	Ocular albinism (HP:0001107)	4.06373858
9	White forelock (HP:0002211)	4.01194373
10	Abnormality of nail color (HP:0100643)	3.78604573
11	Abnormal auditory evoked potentials (HP:0006958)	3.73460527
12	Lip pit (HP:0100267)	3.67220178
13	Patchy hypopigmentation of hair (HP:0011365)	3.51254050
14	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.51225749
15	Short 1st metacarpal (HP:0010034)	3.51225749
16	Iris hypopigmentation (HP:0007730)	3.45739525
17	Chromsome breakage (HP:0040012)	3.39429208
18	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.34431648
19	Freckling (HP:0001480)	3.29872426
20	Ectropion (HP:0000656)	3.20294745
21	Generalized hypopigmentation (HP:0007513)	3.11823773
22	Gaze-evoked nystagmus (HP:0000640)	3.05583983
23	Sensory axonal neuropathy (HP:0003390)	3.02344122
24	Abnormality of the 1st metacarpal (HP:0010009)	3.02012528
25	Hypopigmentation of the fundus (HP:0007894)	3.01069074
26	Thyroid carcinoma (HP:0002890)	2.83430280
27	Abnormality of the frontal sinuses (HP:0002687)	2.72965395
28	Congenital sensorineural hearing impairment (HP:0008527)	2.68015094
29	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.67684079
30	Albinism (HP:0001022)	2.67108293
31	Generalized hypopigmentation of hair (HP:0011358)	2.63260314
32	Fibular hypoplasia (HP:0003038)	2.62407712
33	Chorioretinal atrophy (HP:0000533)	2.57586612
34	Bilateral sensorineural hearing impairment (HP:0008619)	2.53465233
35	Intestinal atresia (HP:0011100)	2.51434849
36	Clubbing of toes (HP:0100760)	2.46192679
37	Long clavicles (HP:0000890)	2.44283627
38	Volvulus (HP:0002580)	2.39834238
39	Vitreoretinal degeneration (HP:0000655)	2.38684004
40	Hypoplasia of the iris (HP:0007676)	2.36688128
41	Duplicated collecting system (HP:0000081)	2.35348518
42	Palmoplantar hyperkeratosis (HP:0000972)	2.33659468
43	Palmar hyperkeratosis (HP:0010765)	2.30568368
44	Ectopic kidney (HP:0000086)	2.30220078
45	Decreased lacrimation (HP:0000633)	2.29660170
46	Hyperventilation (HP:0002883)	2.29431403
47	Hypoalphalipoproteinemia (HP:0003233)	2.28669399
48	Epidermoid cyst (HP:0200040)	2.21420562
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.21349900
50	Short phalanx of the thumb (HP:0009660)	2.21148911
51	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.20066372
52	Abnormality of the renal collecting system (HP:0004742)	2.17694442
53	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.14086022
54	Astigmatism (HP:0000483)	2.11839007
55	Scotoma (HP:0000575)	2.10694244
56	Cutaneous melanoma (HP:0012056)	2.08112927
57	Intrahepatic cholestasis (HP:0001406)	2.04989849
58	Amyotrophic lateral sclerosis (HP:0007354)	2.03193781
59	Thoracolumbar scoliosis (HP:0002944)	2.02094120
60	Hypoplastic ischia (HP:0003175)	1.98774349
61	Abnormality of chromosome stability (HP:0003220)	1.98454867
62	Absent frontal sinuses (HP:0002688)	1.97186350
63	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.95421396
64	Abnormality of DNA repair (HP:0003254)	1.94616878
65	Small hand (HP:0200055)	1.93850428
66	Abnormality of the preputium (HP:0100587)	1.93654750
67	Autoamputation (HP:0001218)	1.91898086
68	Hypoplastic iliac wings (HP:0002866)	1.91709785
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.90294801
70	Curly hair (HP:0002212)	1.90070682
71	Short thumb (HP:0009778)	1.89726723
72	Shoulder girdle muscle weakness (HP:0003547)	1.89640357
73	Abnormality of the axillary hair (HP:0100134)	1.89140785
74	Abnormality of secondary sexual hair (HP:0009888)	1.89140785
75	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.88634778
76	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.88634778
77	Colon cancer (HP:0003003)	1.87251631
78	Abnormality of the ischium (HP:0003174)	1.84343018
79	Cupped ear (HP:0000378)	1.82996126
80	Erythroderma (HP:0001019)	1.82045159
81	Submucous cleft hard palate (HP:0000176)	1.81204430
82	Hypothermia (HP:0002045)	1.79828639
83	Short tibia (HP:0005736)	1.79408396
84	Short chin (HP:0000331)	1.78773243
85	Hypolipoproteinemia (HP:0010981)	1.75194976
86	Abnormality of vision evoked potentials (HP:0000649)	1.70098725
87	Vertebral arch anomaly (HP:0008438)	1.69560593
88	Horizontal nystagmus (HP:0000666)	1.68231259
89	Congenital ichthyosiform erythroderma (HP:0007431)	1.66827645
90	Melanoma (HP:0002861)	1.66540973
91	Abnormality of the fibula (HP:0002991)	1.64682110
92	Hypoplastic pelvis (HP:0008839)	1.64140414
93	Plantar hyperkeratosis (HP:0007556)	1.63153564
94	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.63149927
95	Anhidrosis (HP:0000970)	1.62479300
96	Duodenal stenosis (HP:0100867)	1.61850022
97	Small intestinal stenosis (HP:0012848)	1.61850022
98	Rimmed vacuoles (HP:0003805)	1.61384373
99	Thickened calvaria (HP:0002684)	1.61072058
100	Hypoplastic labia majora (HP:0000059)	1.60559617

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	6.33449746
2	FRK	4.74201308
3	MUSK	4.67497150
4	AKT3	3.76205296
5	BMPR1B	2.83798870
6	TAF1	2.79023659
7	PBK	2.64118562
8	STK24	2.22751080
9	STK38L	2.21164226
10	WEE1	1.95568709
11	PIK3CG	1.70357178
12	LATS1	1.65655818
13	CASK	1.59903092
14	TGFBR1	1.53263208
15	STK39	1.51583764
16	PDK2	1.50657196
17	MKNK2	1.48030115
18	STK3	1.47208069
19	YES1	1.46969004
20	ERBB3	1.46786805
21	MAP3K4	1.43939853
22	BRD4	1.39534434
23	MST4	1.37097065
24	EPHA4	1.32884105
25	MARK3	1.24017918
26	MET	1.23159816
27	NEK9	1.23099563
28	CSNK1A1L	1.20520254
29	PLK2	1.18636798
30	MELK	1.18521007
31	PTK2B	1.15963551
32	NUAK1	1.12297604
33	NTRK3	1.08999625
34	CSNK1G2	1.07666617
35	PAK3	1.07377870
36	SGK2	1.06866055
37	FER	1.04626102
38	BMPR2	1.02841440
39	CSNK1G1	0.99042879
40	MST1R	0.96710963
41	NEK6	0.88421748
42	OXSR1	0.87777434
43	MKNK1	0.85615993
44	ADRBK2	0.84195283
45	WNK3	0.79273526
46	CAMK1G	0.78313876
47	GRK1	0.77115073
48	CDK12	0.76336504
49	NLK	0.74369374
50	PRKAA2	0.71761269
51	SGK3	0.69906354
52	DYRK1A	0.68828344
53	CSNK1G3	0.68272389
54	MAP3K6	0.67241606
55	FGFR1	0.64200209
56	ERBB4	0.61671151
57	CDC7	0.58559478
58	CSNK1D	0.57988199
59	FGFR2	0.57861278
60	RAF1	0.57487183
61	EGFR	0.56834340
62	PRKCH	0.56779823
63	ATM	0.53389633
64	MAPK13	0.52161643
65	IRAK2	0.51202178
66	RIPK1	0.50951073
67	CAMK1D	0.49424384
68	WNK1	0.47676816
69	BRSK1	0.47319477
70	SGK494	0.44964355
71	SGK223	0.44964355
72	PINK1	0.44244829
73	KSR1	0.43735851
74	SCYL2	0.43583017
75	TRPM7	0.43348230
76	SGK1	0.40916653
77	PLK1	0.40883031
78	PIK3CA	0.40614160
79	BCR	0.39716435
80	OBSCN	0.39472471
81	CDK3	0.39241362
82	BRSK2	0.37988585
83	INSRR	0.37946489
84	PNCK	0.37791791
85	WNK4	0.37779687
86	BLK	0.37215897
87	CAMK4	0.36292921
88	CHEK1	0.35226461
89	ATR	0.33590310
90	RPS6KB1	0.33243448
91	GSK3A	0.33119818
92	ADRBK1	0.31301514
93	MAP2K1	0.30482758
94	PKN1	0.29937023
95	PRKCE	0.29899202
96	KIT	0.29402435
97	PRKG1	0.29128814
98	PDGFRB	0.28351430
99	IRAK1	0.27518182
100	FGR	0.27401056

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Dorso-ventral axis formation_Homo sapiens_hsa04320	6.26731141
2	Non-homologous end-joining_Homo sapiens_hsa03450	4.19659708
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.65065677
4	ABC transporters_Homo sapiens_hsa02010	2.73438323
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.56819514
6	Sphingolipid metabolism_Homo sapiens_hsa00600	2.55154605
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.35500149
8	Propanoate metabolism_Homo sapiens_hsa00640	2.27648053
9	Circadian rhythm_Homo sapiens_hsa04710	2.24159510
10	Sulfur metabolism_Homo sapiens_hsa00920	2.16196200
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.77636392
12	Mismatch repair_Homo sapiens_hsa03430	1.74727918
13	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.72595727
14	p53 signaling pathway_Homo sapiens_hsa04115	1.63333329
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58825406
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55620571
17	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.54567018
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.49755104
19	Adherens junction_Homo sapiens_hsa04520	1.48394464
20	Basal transcription factors_Homo sapiens_hsa03022	1.44816113
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42662955
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.41589574
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.40876190
24	Homologous recombination_Homo sapiens_hsa03440	1.35782489
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.32314180
26	One carbon pool by folate_Homo sapiens_hsa00670	1.27511230
27	Cell cycle_Homo sapiens_hsa04110	1.21586732
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19827277
29	Caffeine metabolism_Homo sapiens_hsa00232	1.19492738
30	Protein export_Homo sapiens_hsa03060	1.14736358
31	Melanoma_Homo sapiens_hsa05218	1.14514184
32	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.13335858
33	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13283138
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.12653009
35	Regulation of autophagy_Homo sapiens_hsa04140	1.12326953
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.10179802
37	Colorectal cancer_Homo sapiens_hsa05210	1.07859710
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.03414711
39	Lysine degradation_Homo sapiens_hsa00310	1.00681650
40	RNA polymerase_Homo sapiens_hsa03020	0.94703583
41	Histidine metabolism_Homo sapiens_hsa00340	0.92131837
42	Prostate cancer_Homo sapiens_hsa05215	0.90716262
43	Tight junction_Homo sapiens_hsa04530	0.85704731
44	Thyroid cancer_Homo sapiens_hsa05216	0.81320001
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.76615034
46	Choline metabolism in cancer_Homo sapiens_hsa05231	0.75641287
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73886770
48	Fatty acid elongation_Homo sapiens_hsa00062	0.67759113
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.67751149
50	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.67578903
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67541812
52	Folate biosynthesis_Homo sapiens_hsa00790	0.67174385
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66427941
54	Taste transduction_Homo sapiens_hsa04742	0.66427860
55	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.65671170
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.65632752
57	RNA transport_Homo sapiens_hsa03013	0.65104788
58	Small cell lung cancer_Homo sapiens_hsa05222	0.63664108
59	Melanogenesis_Homo sapiens_hsa04916	0.62778167
60	Endometrial cancer_Homo sapiens_hsa05213	0.62265958
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62265621
62	Serotonergic synapse_Homo sapiens_hsa04726	0.60921169
63	Oocyte meiosis_Homo sapiens_hsa04114	0.55156245
64	Hippo signaling pathway_Homo sapiens_hsa04390	0.50512445
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.50179000
66	Purine metabolism_Homo sapiens_hsa00230	0.49491580
67	FoxO signaling pathway_Homo sapiens_hsa04068	0.47093625
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46846192
69	Long-term depression_Homo sapiens_hsa04730	0.46822042
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46736883
71	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.44756671
72	Peroxisome_Homo sapiens_hsa04146	0.43226865
73	MicroRNAs in cancer_Homo sapiens_hsa05206	0.42383004
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.41883880
75	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.40819063
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.40093961
77	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.39967764
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.39681451
79	Phototransduction_Homo sapiens_hsa04744	0.39359920
80	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.39354166
81	mTOR signaling pathway_Homo sapiens_hsa04150	0.38566821
82	Pathways in cancer_Homo sapiens_hsa05200	0.37427974
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35794321
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35544488
85	Glioma_Homo sapiens_hsa05214	0.34551997
86	DNA replication_Homo sapiens_hsa03030	0.31822162
87	Retinol metabolism_Homo sapiens_hsa00830	0.31223069
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.30713016
89	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29565929
90	Alcoholism_Homo sapiens_hsa05034	0.29284698
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28874528
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.28797480
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.28124683
94	Platelet activation_Homo sapiens_hsa04611	0.28093744
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26053984
96	Pancreatic cancer_Homo sapiens_hsa05212	0.25327579
97	Butanoate metabolism_Homo sapiens_hsa00650	0.23767738
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.23317159
99	Chemical carcinogenesis_Homo sapiens_hsa05204	0.22544549
100	Nicotine addiction_Homo sapiens_hsa05033	0.20935367

ZNF75BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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