ZNF76

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.39422360
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.08087354
3negative regulation of cell killing (GO:0031342)5.08087354
4negative regulation of cell size (GO:0045792)4.94043319
5positive regulation of gamma-delta T cell activation (GO:0046645)4.71937075
6mannose metabolic process (GO:0006013)4.71584302
7regulation of gamma-delta T cell differentiation (GO:0045586)4.58606479
8creatine metabolic process (GO:0006600)4.50578448
9regulation of gamma-delta T cell activation (GO:0046643)4.13919148
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89268298
11antigen processing and presentation of endogenous antigen (GO:0019883)3.81916000
12negative thymic T cell selection (GO:0045060)3.75434690
13histone H4 deacetylation (GO:0070933)3.74819583
14thymic T cell selection (GO:0045061)3.63051822
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58777468
16negative T cell selection (GO:0043383)3.51037150
17positive regulation of triglyceride lipase activity (GO:0061365)3.49600407
18positive regulation of lipoprotein lipase activity (GO:0051006)3.49600407
19histone H3 deacetylation (GO:0070932)3.42277461
20phosphatidylglycerol biosynthetic process (GO:0006655)3.41105322
21positive thymic T cell selection (GO:0045059)3.36878609
22negative regulation of necroptotic process (GO:0060546)3.33358807
23regulation of granulocyte differentiation (GO:0030852)3.28258919
24intracellular estrogen receptor signaling pathway (GO:0030520)3.26311341
25positive regulation of granulocyte differentiation (GO:0030854)3.25946325
26germinal center formation (GO:0002467)3.20256693
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.20177909
28Peyers patch development (GO:0048541)3.15334263
29mucosal-associated lymphoid tissue development (GO:0048537)3.15334263
30T cell selection (GO:0045058)3.14654787
313-UTR-mediated mRNA stabilization (GO:0070935)3.13842846
32negative regulation of granulocyte differentiation (GO:0030853)3.12709955
33regulation of cholesterol metabolic process (GO:0090181)3.05004627
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01633499
35tricarboxylic acid metabolic process (GO:0072350)3.01573317
36regulation of ARF GTPase activity (GO:0032312)2.95216249
37retinoic acid receptor signaling pathway (GO:0048384)2.94926943
38amyloid precursor protein catabolic process (GO:0042987)2.92401160
39regulation of necroptotic process (GO:0060544)2.91596232
40cellular response to interleukin-4 (GO:0071353)2.89903168
41muscle filament sliding (GO:0030049)2.89699047
42actin-myosin filament sliding (GO:0033275)2.89699047
43negative regulation of innate immune response (GO:0045824)2.88134396
442-oxoglutarate metabolic process (GO:0006103)2.87603023
45negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.84149124
46B cell receptor signaling pathway (GO:0050853)2.83625206
47negative regulation of necrotic cell death (GO:0060547)2.82426975
48response to muramyl dipeptide (GO:0032495)2.81410687
49histone H4-K8 acetylation (GO:0043982)2.80511895
50histone H4-K5 acetylation (GO:0043981)2.80511895
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79222747
52histone H4-K16 acetylation (GO:0043984)2.74396196
53detection of bacterium (GO:0016045)2.73794512
54NIK/NF-kappaB signaling (GO:0038061)2.73212255
55NADH metabolic process (GO:0006734)2.72710356
56response to interleukin-4 (GO:0070670)2.72597782
57modulation by virus of host process (GO:0019054)2.69449640
58peptidyl-arginine omega-N-methylation (GO:0035247)2.68610150
59histone H3-K9 demethylation (GO:0033169)2.64564167
60positive regulation of B cell differentiation (GO:0045579)2.64104116
61cellular hyperosmotic response (GO:0071474)2.63407468
62regulation of necrotic cell death (GO:0010939)2.59495280
63negative regulation of myotube differentiation (GO:0010832)2.58051628
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55311013
65response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.54950400
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54257121
67glycogen catabolic process (GO:0005980)2.52418322
68positive T cell selection (GO:0043368)2.49072440
69negative regulation of lymphocyte mediated immunity (GO:0002707)2.48440421
70detection of other organism (GO:0098543)2.47951491
71pinocytosis (GO:0006907)2.46551123
72skeletal muscle contraction (GO:0003009)2.45889440
73amyloid precursor protein metabolic process (GO:0042982)2.45113725
74positive regulation of histone deacetylation (GO:0031065)2.43684345
75retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42913443
76barbed-end actin filament capping (GO:0051016)2.42409758
77dosage compensation (GO:0007549)2.42132865
78response to laminar fluid shear stress (GO:0034616)2.42076754
79histone H4-K12 acetylation (GO:0043983)2.42042357
80regulation of monocyte differentiation (GO:0045655)2.40263891
81proline biosynthetic process (GO:0006561)2.39399962
82positive regulation of myotube differentiation (GO:0010831)2.39234717
83regulation of histone H3-K27 methylation (GO:0061085)2.38991784
84positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38802222
85regulation of cytokine production involved in inflammatory response (GO:1900015)2.36998785
86mature B cell differentiation involved in immune response (GO:0002313)2.36598719
87leukocyte aggregation (GO:0070486)2.35770836
88regulation of ARF protein signal transduction (GO:0032012)2.35602846
89glucan catabolic process (GO:0009251)2.35171929
90galactose catabolic process (GO:0019388)2.34790153
91purine nucleotide salvage (GO:0032261)2.34341559
92snRNA metabolic process (GO:0016073)2.33596263
93cardiolipin metabolic process (GO:0032048)2.32977755
94regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31832236
95pentose-phosphate shunt (GO:0006098)2.31755478
96regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.31639998
97peptidyl-lysine dimethylation (GO:0018027)2.31492772
98negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31391014
99regulation of cholesterol biosynthetic process (GO:0045540)2.31355905
100retrograde transport, endosome to Golgi (GO:0042147)2.30736661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.28084574
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.12605042
3MYC_22102868_ChIP-Seq_BL_Human2.99037257
4LXR_22292898_ChIP-Seq_THP-1_Human2.58308466
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42934673
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.39271022
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.38004987
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.28198124
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15020906
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.14246006
11KDM2B_26808549_Chip-Seq_DND41_Human2.09453451
12TCF7_22412390_ChIP-Seq_EML_Mouse2.05519186
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00970672
14MAF_26560356_Chip-Seq_TH1_Human2.00092917
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96129217
16P68_20966046_ChIP-Seq_HELA_Human1.92011411
17UTX_26944678_Chip-Seq_JUKART_Human1.89696757
18MAF_26560356_Chip-Seq_TH2_Human1.86961549
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83118875
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82787923
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79230439
22* VDR_24763502_ChIP-Seq_THP-1_Human1.78549647
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78498156
24RACK7_27058665_Chip-Seq_MCF-7_Human1.74269093
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72721130
26MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70919220
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.69856275
28CIITA_25753668_ChIP-Seq_RAJI_Human1.69126249
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67773647
30GATA1_19941827_ChIP-Seq_MEL_Mouse1.67007831
31BCL6_27268052_Chip-Seq_Bcells_Human1.64011399
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63977976
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62703000
34SCL_19346495_ChIP-Seq_HPC-7_Human1.60523359
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.59340671
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59075774
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.58376352
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56365268
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56330213
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.54457677
41SMC4_20622854_ChIP-Seq_HELA_Human1.54310433
42BCOR_27268052_Chip-Seq_Bcells_Human1.48219605
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47102906
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46609016
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44990677
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43713116
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43404349
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42153989
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40679470
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39199802
51PU.1_20513432_ChIP-Seq_Bcells_Mouse1.38735461
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36311522
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35948895
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35407371
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.34691372
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34416367
57SPI1_23127762_ChIP-Seq_K562_Human1.33577416
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31328742
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31164814
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30799981
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27500238
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26648288
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26630564
64* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26152818
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25929394
66CREB1_26743006_Chip-Seq_LNCaP_Human1.24657579
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24534158
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23428683
69CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22377722
70CTCF_26484167_Chip-Seq_Bcells_Mouse1.21789073
71NCOR1_26117541_ChIP-Seq_K562_Human1.20907964
72MYB_26560356_Chip-Seq_TH1_Human1.19190697
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18446562
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17759786
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17369801
76ETS1_21867929_ChIP-Seq_TH2_Mouse1.17340880
77CTCF_21964334_Chip-Seq_Bcells_Human1.16451933
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15814197
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15713055
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15334802
81MYB_26560356_Chip-Seq_TH2_Human1.15253553
82RARB_24833708_ChIP-Seq_LIVER_Mouse1.14833077
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14069655
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13837419
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13808875
86PHF8_20622854_ChIP-Seq_HELA_Human1.13664042
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12891475
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11912359
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09221941
90SPI1_23547873_ChIP-Seq_NB4_Human1.08134314
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07876745
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.07499423
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06913565
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06717535
95SA1_27219007_Chip-Seq_Bcells_Human1.05987690
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05385204
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04170297
98CTCF_27219007_Chip-Seq_Bcells_Human1.03968270
99ZNF263_19887448_ChIP-Seq_K562_Human1.03696118
100KDM2B_26808549_Chip-Seq_K562_Human1.03587146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.75710937
2MP0000751_myopathy3.36825830
3MP0008260_abnormal_autophagy3.25200006
4MP0003191_abnormal_cellular_cholesterol3.03901970
5MP0003172_abnormal_lysosome_physiology2.82034809
6MP0009278_abnormal_bone_marrow2.73058723
7MP0005058_abnormal_lysosome_morphology2.70715448
8MP0003436_decreased_susceptibility_to2.67177923
9MP0003763_abnormal_thymus_physiology2.47025983
10MP0004185_abnormal_adipocyte_glucose2.45206135
11MP0003646_muscle_fatigue2.36204163
12MP0009840_abnormal_foam_cell2.25445259
13MP0003303_peritoneal_inflammation2.01347719
14MP0005666_abnormal_adipose_tissue1.95522777
15MP0002396_abnormal_hematopoietic_system1.92618435
16MP0008995_early_reproductive_senescence1.81346637
17MP0003329_amyloid_beta_deposits1.79547240
18MP0004036_abnormal_muscle_relaxation1.78947572
19MP0001545_abnormal_hematopoietic_system1.75336172
20MP0005397_hematopoietic_system_phenotyp1.75336172
21MP0005464_abnormal_platelet_physiology1.72122384
22MP0005330_cardiomyopathy1.69629548
23MP0002822_catalepsy1.68934170
24MP0000003_abnormal_adipose_tissue1.63224639
25MP0000747_muscle_weakness1.58422088
26MP0000759_abnormal_skeletal_muscle1.55791393
27MP0002419_abnormal_innate_immunity1.55017080
28MP0003183_abnormal_peptide_metabolism1.54995962
29MP0005375_adipose_tissue_phenotype1.54887555
30MP0003656_abnormal_erythrocyte_physiolo1.54623563
31MP0004087_abnormal_muscle_fiber1.53392259
32MP0004233_abnormal_muscle_weight1.51627976
33MP0000678_abnormal_parathyroid_gland1.49756942
34MP0001800_abnormal_humoral_immune1.49306409
35MP0000465_gastrointestinal_hemorrhage1.48702434
36MP0000749_muscle_degeneration1.48689299
37MP0002398_abnormal_bone_marrow1.45621868
38MP0002106_abnormal_muscle_physiology1.43127806
39MP0003724_increased_susceptibility_to1.41631910
40MP0001873_stomach_inflammation1.41440199
41MP0005670_abnormal_white_adipose1.40322952
42MP0005025_abnormal_response_to1.40130854
43MP0002269_muscular_atrophy1.39847395
44MP0009333_abnormal_splenocyte_physiolog1.38922946
45MP0005000_abnormal_immune_tolerance1.38147903
46MP0000703_abnormal_thymus_morphology1.36933497
47MP0002420_abnormal_adaptive_immunity1.36084341
48MP0001819_abnormal_immune_cell1.33442390
49MP0002132_abnormal_respiratory_system1.32669053
50MP0002723_abnormal_immune_serum1.32281644
51MP0000681_abnormal_thyroid_gland1.29519928
52MP0002332_abnormal_exercise_endurance1.28866002
53MP0005360_urolithiasis1.28780712
54MP0001835_abnormal_antigen_presentation1.27808184
55MP0004145_abnormal_muscle_electrophysio1.26396284
56MP0002452_abnormal_antigen_presenting1.25695317
57MP0002722_abnormal_immune_system1.21076218
58MP0004510_myositis1.19388845
59MP0002249_abnormal_larynx_morphology1.18093462
60MP0000716_abnormal_immune_system1.17480407
61MP0000689_abnormal_spleen_morphology1.16428058
62MP0002971_abnormal_brown_adipose1.15570369
63MP0006036_abnormal_mitochondrial_physio1.13904363
64MP0004808_abnormal_hematopoietic_stem1.13671731
65MP0010630_abnormal_cardiac_muscle1.12997940
66MP0000685_abnormal_immune_system1.10835133
67MP0002405_respiratory_system_inflammati1.10750276
68MP0001790_abnormal_immune_system1.09557028
69MP0005387_immune_system_phenotype1.09557028
70MP0002429_abnormal_blood_cell1.08782242
71MP0004947_skin_inflammation1.08685532
72MP0002009_preneoplasia1.08427967
73MP0005369_muscle_phenotype1.07954314
74MP0005075_abnormal_melanosome_morpholog1.05239719
75MP0005499_abnormal_olfactory_system1.05118041
76MP0005394_taste/olfaction_phenotype1.05118041
77MP0000604_amyloidosis1.04362705
78MP0008789_abnormal_olfactory_epithelium1.03066610
79MP0004130_abnormal_muscle_cell1.00009949
80MP0001533_abnormal_skeleton_physiology0.99625453
81MP0002970_abnormal_white_adipose0.96071078
82MP0008961_abnormal_basal_metabolism0.94538677
83MP0006138_congestive_heart_failure0.93944020
84MP0000750_abnormal_muscle_regeneration0.92191362
85MP0005076_abnormal_cell_differentiation0.91169856
86MP0004084_abnormal_cardiac_muscle0.90275447
87MP0000733_abnormal_muscle_development0.88484702
88MP0008874_decreased_physiological_sensi0.86148789
89MP0003221_abnormal_cardiomyocyte_apopto0.85923505
90MP0003786_premature_aging0.85667043
91MP0003300_gastrointestinal_ulcer0.84465200
92MP0000858_altered_metastatic_potential0.82497170
93MP0005535_abnormal_body_temperature0.81709089
94MP0001851_eye_inflammation0.80040677
95MP0002127_abnormal_cardiovascular_syste0.79585871
96MP0003828_pulmonary_edema0.76896436
97MP0002139_abnormal_hepatobiliary_system0.73575344
98MP0004381_abnormal_hair_follicle0.73102818
99MP0000013_abnormal_adipose_tissue0.70946262
100MP0002998_abnormal_bone_remodeling0.70253035

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.55765849
2Myopathic facies (HP:0002058)4.05812441
3Centrally nucleated skeletal muscle fibers (HP:0003687)3.49791283
4Myoglobinuria (HP:0002913)3.44479203
5Ragged-red muscle fibers (HP:0003200)3.41043288
6Rhabdomyolysis (HP:0003201)3.34512618
7Muscle fiber inclusion bodies (HP:0100299)3.25751425
8Asymmetric septal hypertrophy (HP:0001670)3.23554671
9Colitis (HP:0002583)3.19147859
10Nemaline bodies (HP:0003798)3.06261032
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.04021092
12Fatigue (HP:0012378)3.00807854
13Muscle stiffness (HP:0003552)2.85343245
14Recurrent abscess formation (HP:0002722)2.76124245
15Increased connective tissue (HP:0009025)2.75388866
16Eczematoid dermatitis (HP:0000976)2.74248620
17Progressive muscle weakness (HP:0003323)2.72937733
18Gastrointestinal inflammation (HP:0004386)2.72740486
19Ulnar deviation of the wrist (HP:0003049)2.68711848
20Abnormal gallbladder physiology (HP:0012438)2.62041791
21Cholecystitis (HP:0001082)2.62041791
22Distal lower limb muscle weakness (HP:0009053)2.57283900
23Distal lower limb amyotrophy (HP:0008944)2.45742265
24Exercise-induced muscle cramps (HP:0003710)2.43978068
25EMG: myopathic abnormalities (HP:0003458)2.43524054
26Abnormality of skeletal muscle fiber size (HP:0012084)2.41172194
27Recurrent bacterial skin infections (HP:0005406)2.40937778
28EMG: neuropathic changes (HP:0003445)2.39331819
29Type 1 muscle fiber predominance (HP:0003803)2.38048243
30Inflammation of the large intestine (HP:0002037)2.35285074
31Elevated erythrocyte sedimentation rate (HP:0003565)2.31581721
32Supranuclear gaze palsy (HP:0000605)2.28121246
33Panhypogammaglobulinemia (HP:0003139)2.27979280
34Difficulty climbing stairs (HP:0003551)2.27955987
35Myositis (HP:0100614)2.27334334
36Increased variability in muscle fiber diameter (HP:0003557)2.25288447
37Acute hepatic failure (HP:0006554)2.21140873
38Muscle fiber splitting (HP:0003555)2.20998093
39Cellulitis (HP:0100658)2.19655977
40Difficulty running (HP:0009046)2.16159789
41Sudden death (HP:0001699)2.14626745
42Abnormality of lateral ventricle (HP:0030047)2.14277989
43Thoracic kyphosis (HP:0002942)2.12436905
44Cholelithiasis (HP:0001081)2.12061452
45Lymphangioma (HP:0100764)2.12014292
46Chest pain (HP:0100749)2.11417279
47Slow saccadic eye movements (HP:0000514)2.11072987
48Abnormality of the thoracic spine (HP:0100711)2.09978663
49Progressive microcephaly (HP:0000253)2.08969680
50Granulocytopenia (HP:0001913)2.08878984
51Interstitial pulmonary disease (HP:0006530)2.08691550
52Agammaglobulinemia (HP:0004432)2.06737004
53Recurrent fungal infections (HP:0002841)2.03092378
54Purpura (HP:0000979)2.01347770
55Abnormality of the fingertips (HP:0001211)2.00819359
56Bulbar palsy (HP:0001283)2.00478781
57Hypertensive crisis (HP:0100735)2.00210049
58Easy fatigability (HP:0003388)1.98954218
59Papilledema (HP:0001085)1.97894549
60Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97880477
61Abnormality of polysaccharide metabolism (HP:0011012)1.97880477
62Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97880477
63Dysostosis multiplex (HP:0000943)1.97580984
64Prolonged bleeding time (HP:0003010)1.97422199
65Broad distal phalanx of finger (HP:0009836)1.97147329
66Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96883159
67Dicarboxylic aciduria (HP:0003215)1.96883159
68Loss of speech (HP:0002371)1.95756700
69Reticulocytosis (HP:0001923)1.94973942
70Mediastinal lymphadenopathy (HP:0100721)1.93827311
71Epistaxis (HP:0000421)1.93512366
72Hyporeflexia of lower limbs (HP:0002600)1.93143700
73Abnormality of macrophages (HP:0004311)1.92087156
74Hemorrhage of the eye (HP:0011885)1.89573578
75Petechiae (HP:0000967)1.89150757
76Spontaneous hematomas (HP:0007420)1.88120980
77Gastrointestinal stroma tumor (HP:0100723)1.86892368
78Mucopolysacchariduria (HP:0008155)1.84743167
79Urinary glycosaminoglycan excretion (HP:0003541)1.84743167
80Seborrheic dermatitis (HP:0001051)1.84386258
81Restrictive lung disease (HP:0002091)1.84196161
82Growth hormone excess (HP:0000845)1.83994646
83Ankle clonus (HP:0011448)1.82671509
84Neck muscle weakness (HP:0000467)1.80669791
85Hepatosplenomegaly (HP:0001433)1.79943443
86Increased serum ferritin (HP:0003281)1.78929649
87Increased IgE level (HP:0003212)1.78282731
88Abnormal gallbladder morphology (HP:0012437)1.77850635
89Meningitis (HP:0001287)1.77341608
90Gastrointestinal infarctions (HP:0005244)1.76435463
91Ventricular tachycardia (HP:0004756)1.76333891
92Recurrent viral infections (HP:0004429)1.76277541
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76085128
94Bundle branch block (HP:0011710)1.76078112
95Neuronal loss in central nervous system (HP:0002529)1.75125662
96Chronic obstructive pulmonary disease (HP:0006510)1.74946756
97Obstructive lung disease (HP:0006536)1.74946756
98Round ear (HP:0100830)1.73137629
99Cerebral palsy (HP:0100021)1.72200410
100Athetosis (HP:0002305)1.71863025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.55248171
2TRIB33.34172188
3MAP4K12.87271823
4PRPF4B2.81738117
5MAP2K32.45805116
6SIK12.28107073
7TNK22.14734041
8TYK22.00438972
9TTN1.89462206
10TAOK31.85698113
11IRAK31.85277505
12SIK21.82328956
13EPHB11.80515170
14SMG11.72066038
15ICK1.68524465
16GRK61.67835140
17MAP3K111.67485210
18TESK21.64830471
19TESK11.64628624
20OBSCN1.64488851
21BCKDK1.52746298
22TBK11.51159640
23MARK21.48961782
24PHKG11.45744530
25PHKG21.45744530
26ZAP701.44145365
27PRKD31.42171763
28SIK31.41690944
29MAP3K71.38726603
30MAP4K21.34804291
31RIPK41.24804242
32NME21.24118240
33BLK1.20531847
34PRKD21.19689437
35MAP3K61.18300082
36FGFR41.17643364
37CDC42BPA1.15281208
38HIPK21.14884760
39JAK31.12212928
40MAPK121.10060099
41MAPK111.08511602
42PKN21.05584109
43BTK1.05270798
44MAP3K131.05089099
45EEF2K1.03193204
46FES1.02471175
47TAOK20.99156550
48ARAF0.98056269
49MAP3K30.97996215
50CDK120.94967048
51PTK60.93596254
52CSF1R0.90481474
53RIPK10.87956047
54JAK10.83527085
55IKBKE0.82964540
56MAP3K140.82503686
57KDR0.81969273
58CDK40.81056690
59MAPK70.80384868
60CAMKK10.79805284
61DYRK1B0.78702662
62CDK90.77975901
63SYK0.74426260
64IRAK40.73819323
65MAP3K10.72743305
66PIM20.71246504
67HCK0.70514101
68MARK30.68643837
69MAP3K100.66454797
70PDK10.65527628
71PDPK10.64966321
72TAOK10.61593816
73STK380.61441029
74KIT0.60312367
75VRK20.59966296
76NME10.59488821
77EPHA30.58765527
78RPS6KL10.58646404
79RPS6KC10.58646404
80MTOR0.57782466
81MAP2K20.55568025
82ITK0.55059944
83PINK10.52658045
84BMX0.51206012
85PRKD10.48762226
86RPS6KA20.47115922
87JAK20.46947686
88CDK70.44348793
89LCK0.42760734
90MAP2K60.42144328
91LYN0.41255778
92IRAK20.40582020
93SCYL20.40406824
94RET0.39829452
95MAPKAPK20.39718110
96PRKAA10.39647201
97RPS6KA60.38583200
98MAP3K80.38388398
99KSR20.37646992
100LRRK20.37414328

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.20192762
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.80738001
3Sulfur relay system_Homo sapiens_hsa041222.62744777
4Fructose and mannose metabolism_Homo sapiens_hsa000512.29386157
5Acute myeloid leukemia_Homo sapiens_hsa052212.28368444
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.22667796
7Primary immunodeficiency_Homo sapiens_hsa053402.15514389
8Pentose phosphate pathway_Homo sapiens_hsa000302.05935506
9Notch signaling pathway_Homo sapiens_hsa043302.04111817
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.03798273
11Base excision repair_Homo sapiens_hsa034101.98094658
12Biosynthesis of amino acids_Homo sapiens_hsa012301.67583967
13B cell receptor signaling pathway_Homo sapiens_hsa046621.67185988
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.56552049
15Carbon metabolism_Homo sapiens_hsa012001.56422124
16Non-small cell lung cancer_Homo sapiens_hsa052231.54670126
17Inositol phosphate metabolism_Homo sapiens_hsa005621.49627788
18Chronic myeloid leukemia_Homo sapiens_hsa052201.42852128
19Osteoclast differentiation_Homo sapiens_hsa043801.39066723
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35064034
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33078147
22Lysine degradation_Homo sapiens_hsa003101.31605063
23Insulin signaling pathway_Homo sapiens_hsa049101.29261210
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28777009
25Herpes simplex infection_Homo sapiens_hsa051681.25039234
26Galactose metabolism_Homo sapiens_hsa000521.22153440
27Leishmaniasis_Homo sapiens_hsa051401.18086527
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16414806
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14950127
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12314525
31Insulin resistance_Homo sapiens_hsa049311.10770313
32AMPK signaling pathway_Homo sapiens_hsa041521.10642310
33VEGF signaling pathway_Homo sapiens_hsa043701.09025684
34Lysosome_Homo sapiens_hsa041421.07509639
35Pancreatic cancer_Homo sapiens_hsa052121.05450798
36Viral myocarditis_Homo sapiens_hsa054161.04289982
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.02725566
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99056765
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98137168
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96435667
41mTOR signaling pathway_Homo sapiens_hsa041500.95056068
42Glucagon signaling pathway_Homo sapiens_hsa049220.92926109
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.92845542
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92290814
45Hepatitis B_Homo sapiens_hsa051610.91167710
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90361668
47Fatty acid metabolism_Homo sapiens_hsa012120.87263738
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84641061
49Influenza A_Homo sapiens_hsa051640.83273258
50Fatty acid elongation_Homo sapiens_hsa000620.83125430
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.82970514
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82955159
53HTLV-I infection_Homo sapiens_hsa051660.82368347
54Arginine biosynthesis_Homo sapiens_hsa002200.82285778
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.82222897
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81282830
57Tuberculosis_Homo sapiens_hsa051520.79723304
58Staphylococcus aureus infection_Homo sapiens_hsa051500.79478346
59Endocytosis_Homo sapiens_hsa041440.79307002
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79179620
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.78657988
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.77367441
63Circadian rhythm_Homo sapiens_hsa047100.75521607
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.75482829
65T cell receptor signaling pathway_Homo sapiens_hsa046600.74640910
66Phenylalanine metabolism_Homo sapiens_hsa003600.74271688
67Regulation of autophagy_Homo sapiens_hsa041400.73306233
68Hepatitis C_Homo sapiens_hsa051600.71804731
69Toxoplasmosis_Homo sapiens_hsa051450.68878019
70Autoimmune thyroid disease_Homo sapiens_hsa053200.68180464
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66762258
72Allograft rejection_Homo sapiens_hsa053300.66072457
73Measles_Homo sapiens_hsa051620.64654870
74Platelet activation_Homo sapiens_hsa046110.62876815
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62270473
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62107878
77GnRH signaling pathway_Homo sapiens_hsa049120.61558748
78Dilated cardiomyopathy_Homo sapiens_hsa054140.60196761
79ABC transporters_Homo sapiens_hsa020100.59772237
80TNF signaling pathway_Homo sapiens_hsa046680.57250197
81Choline metabolism in cancer_Homo sapiens_hsa052310.56225991
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.55485572
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53816448
84Endometrial cancer_Homo sapiens_hsa052130.53678458
85Arginine and proline metabolism_Homo sapiens_hsa003300.53071234
86Viral carcinogenesis_Homo sapiens_hsa052030.52884306
87Apoptosis_Homo sapiens_hsa042100.52448127
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51241349
89Epstein-Barr virus infection_Homo sapiens_hsa051690.50201534
90Graft-versus-host disease_Homo sapiens_hsa053320.49129931
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49053243
92Antigen processing and presentation_Homo sapiens_hsa046120.47626545
93Pertussis_Homo sapiens_hsa051330.46220157
94Vibrio cholerae infection_Homo sapiens_hsa051100.43687112
95Prolactin signaling pathway_Homo sapiens_hsa049170.43385085
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.41213145
97Hematopoietic cell lineage_Homo sapiens_hsa046400.40318140
98Fatty acid degradation_Homo sapiens_hsa000710.40088768
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37935676
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36710232

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