ZNF763

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K6-linked ubiquitination (GO:0085020)9.82514227
2positive regulation of mitochondrial fission (GO:0090141)9.00915673
3regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022358.91079135
4regulation of hexokinase activity (GO:1903299)8.45525781
5regulation of glucokinase activity (GO:0033131)8.45525781
6dopamine transport (GO:0015872)8.09821191
7startle response (GO:0001964)6.82057728
8regulation of oxidative stress-induced neuron death (GO:1903203)6.80728824
9regulation of protein polyubiquitination (GO:1902914)6.61140932
10regulation of mitochondrial fission (GO:0090140)6.45453016
11response to pheromone (GO:0019236)5.93013971
12catecholamine transport (GO:0051937)5.90150076
13norepinephrine metabolic process (GO:0042415)5.54932266
14fucose catabolic process (GO:0019317)5.34088306
15L-fucose metabolic process (GO:0042354)5.34088306
16L-fucose catabolic process (GO:0042355)5.34088306
17neurotransmitter uptake (GO:0001504)4.82625654
18response to manganese ion (GO:0010042)4.77922131
19zinc ion homeostasis (GO:0055069)4.47748971
20regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)4.38364036
21negative regulation of actin filament bundle assembly (GO:0032232)4.37951237
22monoamine transport (GO:0015844)4.19256465
23regulation of type B pancreatic cell apoptotic process (GO:2000674)4.08471237
24regulation of mitochondrial translation (GO:0070129)3.98244006
25axoneme assembly (GO:0035082)3.91866111
26cellular response to ammonium ion (GO:0071242)3.90796131
27regulation of dopamine secretion (GO:0014059)3.89309201
28protein localization to cilium (GO:0061512)3.75890760
29mitochondrion degradation (GO:0000422)3.63614777
30detection of light stimulus involved in visual perception (GO:0050908)3.53620834
31detection of light stimulus involved in sensory perception (GO:0050962)3.53620834
32platelet dense granule organization (GO:0060155)3.53178468
33negative regulation of reactive oxygen species metabolic process (GO:2000378)3.49696310
34cytochrome complex assembly (GO:0017004)3.46508808
35mitochondrial fission (GO:0000266)3.41915518
36epithelial cilium movement (GO:0003351)3.41858310
37nitric oxide mediated signal transduction (GO:0007263)3.36418646
38phenylpropanoid metabolic process (GO:0009698)3.27988383
39glycerophospholipid catabolic process (GO:0046475)3.25726033
40piRNA metabolic process (GO:0034587)3.24458700
41behavioral response to nicotine (GO:0035095)3.20332684
42RNA destabilization (GO:0050779)3.19751868
43C4-dicarboxylate transport (GO:0015740)3.17046023
44regulation of actin nucleation (GO:0051125)3.11238401
45cellular response to monoamine stimulus (GO:0071868)3.09705297
46cellular response to catecholamine stimulus (GO:0071870)3.09705297
47neural tube formation (GO:0001841)3.07739268
48intraciliary transport (GO:0042073)3.04785660
49apical protein localization (GO:0045176)3.04265685
50protein K63-linked ubiquitination (GO:0070534)3.01407404
51establishment of protein localization to Golgi (GO:0072600)2.99684308
52protein targeting to Golgi (GO:0000042)2.96733854
53cellular ketone body metabolic process (GO:0046950)2.93330362
54protein localization to Golgi apparatus (GO:0034067)2.92180532
55dopamine metabolic process (GO:0042417)2.90330190
56interkinetic nuclear migration (GO:0022027)2.85971671
57negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.84013026
58response to catecholamine (GO:0071869)2.80325641
59response to monoamine (GO:0071867)2.80325641
60xenobiotic catabolic process (GO:0042178)2.76873956
61alkaloid metabolic process (GO:0009820)2.76051156
62branched-chain amino acid catabolic process (GO:0009083)2.75441218
63cilium movement (GO:0003341)2.74259593
64protein complex biogenesis (GO:0070271)2.74007543
65pyrimidine nucleobase catabolic process (GO:0006208)2.73880896
66retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73378361
67regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.71719629
68cellular protein catabolic process (GO:0044257)2.67987004
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67661625
70cornea development in camera-type eye (GO:0061303)2.66914744
71positive regulation of DNA binding (GO:0043388)2.66825990
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65976913
73synaptic transmission, cholinergic (GO:0007271)2.64485591
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63404222
75protein K48-linked ubiquitination (GO:0070936)2.62003992
76somite development (GO:0061053)2.61293584
77regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.59711829
78dentate gyrus development (GO:0021542)2.59081168
79ketone body metabolic process (GO:1902224)2.58347642
80cellular response to toxic substance (GO:0097237)2.56747642
81kidney morphogenesis (GO:0060993)2.54273699
82histone H2A ubiquitination (GO:0033522)2.53556421
83positive regulation of glycolytic process (GO:0045821)2.53408328
84protein autoubiquitination (GO:0051865)2.52536696
85negative regulation of cellular carbohydrate metabolic process (GO:0010677)2.49365617
86DNA methylation involved in gamete generation (GO:0043046)2.49279071
87benzene-containing compound metabolic process (GO:0042537)2.48635601
88protein polyglutamylation (GO:0018095)2.48554612
89cellular response to leptin stimulus (GO:0044320)2.47499238
90negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47372017
91positive regulation of translational initiation (GO:0045948)2.47300480
92negative regulation of DNA recombination (GO:0045910)2.46534664
93aspartate family amino acid catabolic process (GO:0009068)2.42490699
94respiratory chain complex IV assembly (GO:0008535)2.41597015
95reciprocal DNA recombination (GO:0035825)2.39612835
96reciprocal meiotic recombination (GO:0007131)2.39612835
97branched-chain amino acid metabolic process (GO:0009081)2.39570141
98regulation of catecholamine secretion (GO:0050433)2.39294354
99phosphatidylethanolamine metabolic process (GO:0046337)2.39277119
100mitochondrial respiratory chain complex assembly (GO:0033108)2.39151305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.23673298
2IGF1R_20145208_ChIP-Seq_DFB_Human3.84146822
3ZNF274_21170338_ChIP-Seq_K562_Hela3.27036750
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.86846748
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.86168752
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70433751
7VDR_22108803_ChIP-Seq_LS180_Human2.55363929
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35462126
9GBX2_23144817_ChIP-Seq_PC3_Human2.23382220
10EWS_26573619_Chip-Seq_HEK293_Human2.13273194
11P300_19829295_ChIP-Seq_ESCs_Human2.11541552
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05334216
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.99928221
14ER_23166858_ChIP-Seq_MCF-7_Human1.96268757
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89032818
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88725830
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79634982
18BCAT_22108803_ChIP-Seq_LS180_Human1.75533200
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.71309248
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71021584
21FUS_26573619_Chip-Seq_HEK293_Human1.68882041
22TAF15_26573619_Chip-Seq_HEK293_Human1.68696856
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66996426
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66485524
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.60802113
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56419165
27ELK1_19687146_ChIP-ChIP_HELA_Human1.54820528
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52906821
29CBP_20019798_ChIP-Seq_JUKART_Human1.52906821
30GATA1_22025678_ChIP-Seq_K562_Human1.51835836
31* STAT3_23295773_ChIP-Seq_U87_Human1.51621431
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51544673
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49728378
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.49317848
35SMAD4_21799915_ChIP-Seq_A2780_Human1.48132620
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45966515
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44371107
38AR_25329375_ChIP-Seq_VCAP_Human1.44109149
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43567169
40TCF4_22108803_ChIP-Seq_LS180_Human1.42651984
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.39773821
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39590996
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39281570
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38880036
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38592245
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38014024
47TCF4_23295773_ChIP-Seq_U87_Human1.37264068
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36755459
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36755459
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36084241
51RUNX2_22187159_ChIP-Seq_PCA_Human1.35318000
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34980656
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.32798050
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31629505
55NANOG_19829295_ChIP-Seq_ESCs_Human1.29665973
56SOX2_19829295_ChIP-Seq_ESCs_Human1.29665973
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.28550392
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28075694
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26992075
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.26871813
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26783776
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25629806
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25560221
64TP53_22573176_ChIP-Seq_HFKS_Human1.24653907
65* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24243164
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22838143
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22734275
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20050786
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19778566
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.18824329
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.17551358
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17382601
73P53_22387025_ChIP-Seq_ESCs_Mouse1.17146298
74REST_21632747_ChIP-Seq_MESCs_Mouse1.16466971
75* NCOR_22424771_ChIP-Seq_293T_Human1.13886466
76EZH2_22144423_ChIP-Seq_EOC_Human1.13207263
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12461707
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.12326053
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11477762
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.10699966
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09914185
82CDX2_22108803_ChIP-Seq_LS180_Human1.07592778
83MYC_18940864_ChIP-ChIP_HL60_Human1.07522651
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05653794
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05326666
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.04719966
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.04614598
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04329465
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04291132
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.03317025
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02934103
92* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02446528
93* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00882280
94* FOXA1_25329375_ChIP-Seq_VCAP_Human1.00882280
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00869745
96IRF1_19129219_ChIP-ChIP_H3396_Human1.00328011
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.98048832
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97922060
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.97696756
100RNF2_27304074_Chip-Seq_NSC_Mouse0.97457949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.16174650
2MP0003195_calcinosis4.11678654
3MP0006072_abnormal_retinal_apoptosis3.79739291
4MP0006292_abnormal_olfactory_placode3.49088906
5MP0003787_abnormal_imprinting3.42219931
6MP0008995_early_reproductive_senescence2.83504471
7MP0005646_abnormal_pituitary_gland2.70728173
8MP0004885_abnormal_endolymph2.42479581
9MP0005253_abnormal_eye_physiology2.28932502
10MP0002638_abnormal_pupillary_reflex2.18520304
11MP0003880_abnormal_central_pattern2.18436064
12MP0003122_maternal_imprinting2.10997281
13MP0001485_abnormal_pinna_reflex2.10295329
14MP0005379_endocrine/exocrine_gland_phen2.09267289
15MP0005551_abnormal_eye_electrophysiolog2.00451419
16MP0002272_abnormal_nervous_system2.00050067
17MP0003283_abnormal_digestive_organ1.98307952
18MP0006036_abnormal_mitochondrial_physio1.94158667
19MP0005423_abnormal_somatic_nervous1.91290477
20MP0003879_abnormal_hair_cell1.89216991
21MP0003121_genomic_imprinting1.87603677
22MP0002102_abnormal_ear_morphology1.82905552
23MP0001905_abnormal_dopamine_level1.72261154
24MP0004147_increased_porphyrin_level1.70777181
25MP0006035_abnormal_mitochondrial_morpho1.69207544
26MP0005075_abnormal_melanosome_morpholog1.65189382
27MP0001486_abnormal_startle_reflex1.63032456
28MP0005410_abnormal_fertilization1.62520530
29MP0005645_abnormal_hypothalamus_physiol1.61613800
30MP0003123_paternal_imprinting1.59921384
31MP0009745_abnormal_behavioral_response1.32635403
32MP0000015_abnormal_ear_pigmentation1.29221789
33MP0000427_abnormal_hair_cycle1.28136863
34MP0003724_increased_susceptibility_to1.27236902
35MP0001529_abnormal_vocalization1.25929328
36MP0005535_abnormal_body_temperature1.24120709
37MP0002837_dystrophic_cardiac_calcinosis1.24096954
38MP0002928_abnormal_bile_duct1.22402677
39MP0001986_abnormal_taste_sensitivity1.21208446
40MP0001963_abnormal_hearing_physiology1.18498201
41MP0000026_abnormal_inner_ear1.15881260
42MP0001188_hyperpigmentation1.15794118
43MP0002572_abnormal_emotion/affect_behav1.15595496
44MP0003011_delayed_dark_adaptation1.13573067
45MP0001984_abnormal_olfaction1.13303568
46MP0003646_muscle_fatigue1.12643320
47MP0002229_neurodegeneration1.11975100
48MP0003698_abnormal_male_reproductive1.10745089
49MP0005084_abnormal_gallbladder_morpholo1.08900899
50MP0002163_abnormal_gland_morphology1.08069283
51MP0010386_abnormal_urinary_bladder1.07994717
52MP0001944_abnormal_pancreas_morphology1.07922859
53MP0003172_abnormal_lysosome_physiology1.06974028
54MP0002095_abnormal_skin_pigmentation1.03954339
55MP0005220_abnormal_exocrine_pancreas1.03871356
56MP0002876_abnormal_thyroid_physiology1.00517435
57MP0005195_abnormal_posterior_eye0.99510123
58MP0005174_abnormal_tail_pigmentation0.98794348
59MP0000631_abnormal_neuroendocrine_gland0.98371395
60MP0003567_abnormal_fetal_cardiomyocyte0.97268491
61MP0003119_abnormal_digestive_system0.96845679
62MP0003186_abnormal_redox_activity0.96053598
63MP0009785_altered_susceptibility_to0.95614998
64MP0000470_abnormal_stomach_morphology0.93924297
65MP0005391_vision/eye_phenotype0.93001241
66MP0001929_abnormal_gametogenesis0.92085382
67MP0002938_white_spotting0.89177865
68MP0008789_abnormal_olfactory_epithelium0.88553510
69MP0001501_abnormal_sleep_pattern0.88354280
70MP0002184_abnormal_innervation0.88261898
71MP0000569_abnormal_digit_pigmentation0.85013815
72MP0004742_abnormal_vestibular_system0.83031895
73MP0006276_abnormal_autonomic_nervous0.82407154
74MP0002210_abnormal_sex_determination0.82162257
75MP0008872_abnormal_physiological_respon0.79906238
76MP0009046_muscle_twitch0.79494676
77MP0002752_abnormal_somatic_nervous0.79489065
78MP0002067_abnormal_sensory_capabilities0.77457924
79MP0005332_abnormal_amino_acid0.76874106
80MP0002693_abnormal_pancreas_physiology0.76648868
81MP0002138_abnormal_hepatobiliary_system0.76614065
82MP0000647_abnormal_sebaceous_gland0.76464321
83MP0003959_abnormal_lean_body0.76288173
84MP0000653_abnormal_sex_gland0.76172576
85MP0005167_abnormal_blood-brain_barrier0.75905081
86MP0010329_abnormal_lipoprotein_level0.75105024
87MP0002909_abnormal_adrenal_gland0.74393470
88MP0008775_abnormal_heart_ventricle0.73807629
89MP0003635_abnormal_synaptic_transmissio0.73527028
90MP0004381_abnormal_hair_follicle0.73263819
91MP0005671_abnormal_response_to0.73138910
92MP0001664_abnormal_digestion0.73053917
93MP0002734_abnormal_mechanical_nocicepti0.72573931
94MP0001968_abnormal_touch/_nociception0.72378057
95MP0005085_abnormal_gallbladder_physiolo0.71589369
96MP0001145_abnormal_male_reproductive0.70686704
97MP0001324_abnormal_eye_pigmentation0.69106134
98MP0004142_abnormal_muscle_tone0.67978859
99MP0005083_abnormal_biliary_tract0.67439801
100MP0005394_taste/olfaction_phenotype0.66367296

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)6.69684729
2Aplasia/Hypoplasia of the fovea (HP:0008060)6.69684729
3Anterior segment dysgenesis (HP:0007700)6.13490186
4Abnormality of the fovea (HP:0000493)5.66005002
5Aplasia/Hypoplasia of the macula (HP:0008059)4.35368634
6Aplasia/Hypoplasia affecting the retina (HP:0008061)4.04070427
7Alveolar cell carcinoma (HP:0006519)4.03162751
8Febrile seizures (HP:0002373)3.76822731
9Neoplasm of the tracheobronchial system (HP:0100552)3.71858994
10Genetic anticipation (HP:0003743)3.55860884
11Nephronophthisis (HP:0000090)3.50129069
12Hypoglycemic seizures (HP:0002173)3.45917253
13Medial flaring of the eyebrow (HP:0010747)3.35462830
14Polydipsia (HP:0001959)3.25852339
15Abnormal drinking behavior (HP:0030082)3.25852339
16Molar tooth sign on MRI (HP:0002419)3.20366989
17Abnormality of midbrain morphology (HP:0002418)3.20366989
18Congenital stationary night blindness (HP:0007642)3.18946839
19Abnormality of the renal medulla (HP:0100957)3.18568967
20Progressive cerebellar ataxia (HP:0002073)3.14626981
21Hyperinsulinemic hypoglycemia (HP:0000825)3.10623195
22Thyroiditis (HP:0100646)3.08935962
23Polyuria (HP:0000103)2.99315895
24Chronic hepatic failure (HP:0100626)2.95429490
25Germ cell neoplasia (HP:0100728)2.93892029
263-Methylglutaconic aciduria (HP:0003535)2.89054807
27Hypothermia (HP:0002045)2.80785557
28Abnormality of B cell number (HP:0010975)2.80024360
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.76819391
30Abnormality of the renal cortex (HP:0011035)2.73250237
31Pancreatic cysts (HP:0001737)2.71461612
32Symptomatic seizures (HP:0011145)2.70798304
33Postural instability (HP:0002172)2.68556297
34Agitation (HP:0000713)2.63043674
35Hypoglycemic coma (HP:0001325)2.62762246
36Severe combined immunodeficiency (HP:0004430)2.59791922
37Abnormal rod and cone electroretinograms (HP:0008323)2.56829910
38Methylmalonic acidemia (HP:0002912)2.51876887
39Breast carcinoma (HP:0003002)2.51718811
40Severe muscular hypotonia (HP:0006829)2.44119217
41Pancreatic fibrosis (HP:0100732)2.43678973
42Abnormal urine output (HP:0012590)2.42266656
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.39269835
44B lymphocytopenia (HP:0010976)2.38735013
45Tubular atrophy (HP:0000092)2.38601974
46Gait imbalance (HP:0002141)2.29673209
47Abnormality of calcium-phosphate metabolism (HP:0100530)2.29410168
48Congenital primary aphakia (HP:0007707)2.28610450
49Hyperventilation (HP:0002883)2.26852047
50Gaze-evoked nystagmus (HP:0000640)2.23238711
51Esotropia (HP:0000565)2.22851921
52Abnormality of eosinophils (HP:0001879)2.19423725
53Abnormality of the anterior chamber (HP:0000593)2.18445438
54Eosinophilia (HP:0001880)2.18006962
55Late onset (HP:0003584)2.17506703
56Nephrogenic diabetes insipidus (HP:0009806)2.16707741
57Abnormality of renal excretion (HP:0011036)2.13871895
58Panhypogammaglobulinemia (HP:0003139)2.12455698
59Hypoproteinemia (HP:0003075)2.11820373
60Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.11776449
61True hermaphroditism (HP:0010459)2.09034897
62Absent speech (HP:0001344)2.07503151
63Hypomagnesemia (HP:0002917)2.07316621
64Congenital sensorineural hearing impairment (HP:0008527)2.07108539
65Limb hypertonia (HP:0002509)2.07063930
66Attenuation of retinal blood vessels (HP:0007843)2.03506821
67Tachypnea (HP:0002789)2.02379180
68Abnormality of the line of Schwalbe (HP:0008048)2.01609179
69Pendular nystagmus (HP:0012043)1.99914679
70Absent/shortened dynein arms (HP:0200106)1.99351203
71Dynein arm defect of respiratory motile cilia (HP:0012255)1.99351203
72Type II lissencephaly (HP:0007260)1.96369272
73Retinitis pigmentosa (HP:0000510)1.95504177
74Ketoacidosis (HP:0001993)1.94332986
75Abnormality of macular pigmentation (HP:0008002)1.93916905
76Abnormality of the labia minora (HP:0012880)1.92447208
77Abnormality of vitamin B metabolism (HP:0004340)1.92029646
78Albinism (HP:0001022)1.91582644
79Posterior embryotoxon (HP:0000627)1.90621262
80Tubulointerstitial fibrosis (HP:0005576)1.90606432
81Abolished electroretinogram (ERG) (HP:0000550)1.89838653
82Abnormality of the vitamin B12 metabolism (HP:0004341)1.89721975
83Abnormality of lateral ventricle (HP:0030047)1.85767542
84Decreased central vision (HP:0007663)1.82345001
85Combined immunodeficiency (HP:0005387)1.81992798
86Tetany (HP:0001281)1.81833917
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79098947
88Increased circulating renin level (HP:0000848)1.78515399
89Azoospermia (HP:0000027)1.74311053
90Progressive inability to walk (HP:0002505)1.72838093
91Ketosis (HP:0001946)1.72778064
92Genital tract atresia (HP:0001827)1.68861549
93Abnormal pancreas size (HP:0012094)1.68767661
94Cone-rod dystrophy (HP:0000548)1.66583275
95Stomatitis (HP:0010280)1.64971984
96Abnormal biliary tract physiology (HP:0012439)1.64325106
97Bile duct proliferation (HP:0001408)1.64325106
98Abnormal respiratory epithelium morphology (HP:0012253)1.62800697
99Abnormal respiratory motile cilium morphology (HP:0005938)1.62800697
100Tubulointerstitial abnormality (HP:0001969)1.62124722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.51085859
2PIK3CA2.88438907
3PASK2.85256153
4WNK32.44324510
5PINK111.2916979
6MAP4K21.79097181
7TAOK31.77130282
8NUAK11.72677015
9TRIM281.56925119
10GRK11.54893344
11TESK21.53165818
12ADRBK21.50642800
13TXK1.50562822
14KSR11.42815163
15BCR1.42353587
16PLK21.38768124
17ERBB31.36335238
18BMPR1B1.31273019
19STK101.24661998
20MARK31.22839679
21MAPK131.21258439
22CASK1.19616473
23MAP3K41.14064936
24PTK2B1.12965823
25ACVR1B1.04636990
26DYRK31.00002380
27PAK30.96881760
28INSRR0.92115061
29DYRK20.86922016
30NEK60.81720320
31SIK30.80299169
32PRKCI0.79138149
33NTRK30.78678680
34OXSR10.77447733
35PHKG10.77318558
36PHKG20.77318558
37ADRBK10.75644677
38CCNB10.74489129
39PIK3CG0.71682918
40FER0.70251443
41STK390.70190711
42IKBKE0.68223300
43PRKCG0.64189487
44PRKCE0.62782747
45PRKCQ0.62111846
46STK110.61656801
47EPHB20.61532303
48ZAK0.61208034
49ABL10.60070584
50MAP2K70.59695239
51BRD40.58013401
52FGFR20.57836413
53LRRK20.57202915
54MARK10.53310852
55STK160.52062771
56BCKDK0.50772697
57NLK0.47631889
58MAP2K40.47010341
59SGK20.46697421
60MUSK0.44605820
61TNIK0.43522349
62CSNK1G20.42627191
63STK30.41397553
64SIK20.40163544
65CSNK1A10.39708053
66MINK10.39043152
67CLK10.38765023
68DAPK20.38393304
69VRK10.37256729
70TGFBR20.36065742
71MAP2K60.35658070
72WNK40.33945502
73IKBKB0.33724629
74CSNK1G10.33273196
75SGK4940.33269223
76SGK2230.33269223
77RPS6KB10.33052617
78STK38L0.32416985
79PRKG10.32394897
80KIT0.31812088
81IRAK20.31514640
82PLK30.31374994
83FES0.30614810
84TAOK10.29998294
85ITK0.29966487
86PKN10.29688295
87LYN0.29681841
88CDK50.29525421
89TEC0.29306266
90JAK30.29113728
91CSNK1G30.28943822
92HIPK20.28802603
93MKNK20.26847473
94ERBB20.26810138
95EIF2AK30.26325462
96PRKACA0.26100187
97TNK20.25776073
98PRKAA20.25062257
99LCK0.24976811
100CHUK0.24011314

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.00840586
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.51171174
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.79606170
4Butanoate metabolism_Homo sapiens_hsa006502.74979183
5Non-homologous end-joining_Homo sapiens_hsa034502.67428747
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.45794759
7Phototransduction_Homo sapiens_hsa047442.35916739
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13319563
9Protein export_Homo sapiens_hsa030602.01792374
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.93870889
11Basal transcription factors_Homo sapiens_hsa030221.87154526
12Regulation of autophagy_Homo sapiens_hsa041401.85607583
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84519436
14Peroxisome_Homo sapiens_hsa041461.79263681
15Parkinsons disease_Homo sapiens_hsa050121.68805269
16Fanconi anemia pathway_Homo sapiens_hsa034601.66205321
17Nicotine addiction_Homo sapiens_hsa050331.64440460
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58304220
19Linoleic acid metabolism_Homo sapiens_hsa005911.56477207
20Oxidative phosphorylation_Homo sapiens_hsa001901.55746924
21Homologous recombination_Homo sapiens_hsa034401.53114230
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52584722
23Tryptophan metabolism_Homo sapiens_hsa003801.51237188
24Propanoate metabolism_Homo sapiens_hsa006401.44818989
25Caffeine metabolism_Homo sapiens_hsa002321.40611203
26Ether lipid metabolism_Homo sapiens_hsa005651.39585979
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38647395
28Glycerolipid metabolism_Homo sapiens_hsa005611.37624369
29Primary immunodeficiency_Homo sapiens_hsa053401.34832974
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32709061
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29910665
32Insulin secretion_Homo sapiens_hsa049111.25529455
33RNA polymerase_Homo sapiens_hsa030201.24117105
34Olfactory transduction_Homo sapiens_hsa047401.23611282
35Nitrogen metabolism_Homo sapiens_hsa009101.18516454
36Type I diabetes mellitus_Homo sapiens_hsa049401.14578699
37Folate biosynthesis_Homo sapiens_hsa007901.13725826
38Taste transduction_Homo sapiens_hsa047421.11760789
39Morphine addiction_Homo sapiens_hsa050321.07565560
40Collecting duct acid secretion_Homo sapiens_hsa049661.04712496
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.02909225
42Arachidonic acid metabolism_Homo sapiens_hsa005900.98009998
43GABAergic synapse_Homo sapiens_hsa047270.96059917
44RNA degradation_Homo sapiens_hsa030180.95251544
45Serotonergic synapse_Homo sapiens_hsa047260.88902227
46beta-Alanine metabolism_Homo sapiens_hsa004100.88203313
47Selenocompound metabolism_Homo sapiens_hsa004500.87468979
48Graft-versus-host disease_Homo sapiens_hsa053320.87311363
49Fatty acid degradation_Homo sapiens_hsa000710.86033842
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85488719
51Retinol metabolism_Homo sapiens_hsa008300.83768319
52Chemical carcinogenesis_Homo sapiens_hsa052040.83089379
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82694979
54Type II diabetes mellitus_Homo sapiens_hsa049300.81520424
55Dorso-ventral axis formation_Homo sapiens_hsa043200.79898262
56Gastric acid secretion_Homo sapiens_hsa049710.76836225
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75368618
58Huntingtons disease_Homo sapiens_hsa050160.74835877
59Allograft rejection_Homo sapiens_hsa053300.71709525
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70730241
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.69414557
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69169010
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67203599
64Asthma_Homo sapiens_hsa053100.67133571
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65880311
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65087245
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.64198952
68Fatty acid elongation_Homo sapiens_hsa000620.60680560
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60373988
70Alzheimers disease_Homo sapiens_hsa050100.60176828
71Autoimmune thyroid disease_Homo sapiens_hsa053200.59268928
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58275873
73Cardiac muscle contraction_Homo sapiens_hsa042600.57061897
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55504768
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55045289
76Glutamatergic synapse_Homo sapiens_hsa047240.54550721
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53664241
78Circadian entrainment_Homo sapiens_hsa047130.53018233
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52222571
80Rheumatoid arthritis_Homo sapiens_hsa053230.51499456
81Hedgehog signaling pathway_Homo sapiens_hsa043400.50649062
82Mismatch repair_Homo sapiens_hsa034300.49723151
83Metabolic pathways_Homo sapiens_hsa011000.49670160
84ABC transporters_Homo sapiens_hsa020100.49277568
85Salivary secretion_Homo sapiens_hsa049700.47530744
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45665577
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42900388
88Ovarian steroidogenesis_Homo sapiens_hsa049130.38529669
89Purine metabolism_Homo sapiens_hsa002300.38443631
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37218891
91Dopaminergic synapse_Homo sapiens_hsa047280.37017042
92Cocaine addiction_Homo sapiens_hsa050300.36644059
93Pyrimidine metabolism_Homo sapiens_hsa002400.31518320
94Legionellosis_Homo sapiens_hsa051340.31422008
95Renin secretion_Homo sapiens_hsa049240.30084016
96Hematopoietic cell lineage_Homo sapiens_hsa046400.29036957
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27900211
98Histidine metabolism_Homo sapiens_hsa003400.26834551
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24552671
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24436030

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