ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adult feeding behavior (GO:0008343)	5.83274681
2	metallo-sulfur cluster assembly (GO:0031163)	5.76362514
3	iron-sulfur cluster assembly (GO:0016226)	5.76362514
4	behavioral response to nicotine (GO:0035095)	5.71804061
5	retinal cone cell development (GO:0046549)	5.37480570
6	response to pheromone (GO:0019236)	5.33293846
7	protein K6-linked ubiquitination (GO:0085020)	5.07007474
8	sequestering of actin monomers (GO:0042989)	4.96380174
9	behavioral response to ethanol (GO:0048149)	4.28024796
10	neurotransmitter-gated ion channel clustering (GO:0072578)	4.20696540
11	peptidyl-histidine modification (GO:0018202)	4.06787450
12	positive regulation of prostaglandin secretion (GO:0032308)	3.98797039
13	microtubule depolymerization (GO:0007019)	3.81277147
14	synapsis (GO:0007129)	3.80371333
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.77449267
16	dopaminergic neuron differentiation (GO:0071542)	3.74366524
17	indolalkylamine metabolic process (GO:0006586)	3.65305892
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.63694020
19	ATP synthesis coupled proton transport (GO:0015986)	3.48508793
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.48508793
21	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.46184061
22	midbrain development (GO:0030901)	3.44553347
23	replication fork processing (GO:0031297)	3.44424731
24	hindbrain development (GO:0030902)	3.43932743
25	prenylation (GO:0097354)	3.43915037
26	protein prenylation (GO:0018342)	3.43915037
27	primary amino compound metabolic process (GO:1901160)	3.35207084
28	artery development (GO:0060840)	3.34638208
29	righting reflex (GO:0060013)	3.34328400
30	GTP biosynthetic process (GO:0006183)	3.33623918
31	regulation of mesoderm development (GO:2000380)	3.30567039
32	serotonin metabolic process (GO:0042428)	3.30361392
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.29756725
34	cornea development in camera-type eye (GO:0061303)	3.25910756
35	epithelial cilium movement (GO:0003351)	3.22049994
36	reflex (GO:0060004)	3.21897150
37	somite rostral/caudal axis specification (GO:0032525)	3.20613933
38	chromatin remodeling at centromere (GO:0031055)	3.18201743
39	primitive streak formation (GO:0090009)	3.15199854
40	spinal cord motor neuron differentiation (GO:0021522)	3.12342467
41	regulation of prostaglandin secretion (GO:0032306)	3.11944491
42	photoreceptor cell development (GO:0042461)	3.11736554
43	thalamus development (GO:0021794)	3.11148971
44	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.10141431
45	fucose catabolic process (GO:0019317)	3.09056953
46	L-fucose metabolic process (GO:0042354)	3.09056953
47	L-fucose catabolic process (GO:0042355)	3.09056953
48	CENP-A containing nucleosome assembly (GO:0034080)	3.08644923
49	regulation of meiosis I (GO:0060631)	3.07803226
50	gamma-aminobutyric acid transport (GO:0015812)	3.07529214
51	positive regulation of gastrulation (GO:2000543)	3.07480602
52	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04799768
53	estrogen biosynthetic process (GO:0006703)	3.02479303
54	cilium or flagellum-dependent cell motility (GO:0001539)	3.01049970
55	alkaloid metabolic process (GO:0009820)	2.99222398
56	sulfation (GO:0051923)	2.96450459
57	protein-cofactor linkage (GO:0018065)	2.95683972
58	toxin metabolic process (GO:0009404)	2.94855849
59	positive regulation of fatty acid transport (GO:2000193)	2.92643820
60	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.91089928
61	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.90499301
62	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.89501172
63	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88922000
64	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88922000
65	NADH dehydrogenase complex assembly (GO:0010257)	2.88922000
66	cellular ketone body metabolic process (GO:0046950)	2.87155410
67	UTP biosynthetic process (GO:0006228)	2.86290846
68	protein neddylation (GO:0045116)	2.81110060
69	positive regulation of icosanoid secretion (GO:0032305)	2.80019260
70	dentate gyrus development (GO:0021542)	2.79646263
71	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.79401057
72	negative regulation of systemic arterial blood pressure (GO:0003085)	2.79075308
73	aldehyde catabolic process (GO:0046185)	2.78391633
74	killing of cells of other organism (GO:0031640)	2.77110977
75	disruption of cells of other organism (GO:0044364)	2.77110977
76	intracellular protein transmembrane import (GO:0044743)	2.76827059
77	somite development (GO:0061053)	2.76630014
78	neuron fate determination (GO:0048664)	2.76152785
79	histone exchange (GO:0043486)	2.74462415
80	indole-containing compound metabolic process (GO:0042430)	2.73393859
81	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.71391347
82	DNA double-strand break processing (GO:0000729)	2.71063160
83	eye photoreceptor cell development (GO:0042462)	2.70334750
84	negative regulation of telomere maintenance (GO:0032205)	2.70125233
85	kynurenine metabolic process (GO:0070189)	2.67801680
86	meiotic chromosome segregation (GO:0045132)	2.65588083
87	nucleoside diphosphate phosphorylation (GO:0006165)	2.63257029
88	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.63038836
89	microtubule polymerization or depolymerization (GO:0031109)	2.62735521
90	retinal ganglion cell axon guidance (GO:0031290)	2.62648489
91	indolalkylamine catabolic process (GO:0046218)	2.60623944
92	tryptophan catabolic process (GO:0006569)	2.60623944
93	indole-containing compound catabolic process (GO:0042436)	2.60623944
94	ketone body metabolic process (GO:1902224)	2.58565564
95	thrombin receptor signaling pathway (GO:0070493)	2.56023803
96	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.55594400
97	UTP metabolic process (GO:0046051)	2.54399134
98	rRNA catabolic process (GO:0016075)	2.53663394
99	positive regulation of meiosis (GO:0045836)	2.52179765
100	intestinal epithelial cell development (GO:0060576)	2.50387424

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.22424550
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.16434701
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.44202924
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.98086610
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.81379557
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.73783614
7	VDR_22108803_ChIP-Seq_LS180_Human	2.60114377
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.42278067
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29200927
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27189422
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.23613002
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.22511417
13	EWS_26573619_Chip-Seq_HEK293_Human	2.18645322
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16792458
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14104358
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.12459671
17	FUS_26573619_Chip-Seq_HEK293_Human	2.08193206
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.06281875
19	P300_19829295_ChIP-Seq_ESCs_Human	2.02712910
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.02317065
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.95059164
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.93084013
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84530804
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.84405544
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.81487971
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.81017425
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.76680092
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.67798626
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63765713
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.61538108
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.60156437
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.59936470
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59551273
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57261804
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53193534
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50104292
37	AR_25329375_ChIP-Seq_VCAP_Human	1.49759552
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.49092846
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48906610
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48657777
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48271178
42	STAT3_23295773_ChIP-Seq_U87_Human	1.45184360
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.44414846
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43865271
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43803121
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.43729999
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43300911
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42559242
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42559242
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.42548195
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42331283
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.41385286
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.41385286
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41056341
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.41056341
56	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.39392370
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36627906
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.34595501
59	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.33095148
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31220361
61	VDR_23849224_ChIP-Seq_CD4+_Human	1.31096119
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30374255
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29394566
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29394566
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26420435
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25248818
67	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23915873
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23101611
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.22240055
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21856442
71	TCF4_23295773_ChIP-Seq_U87_Human	1.20918412
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20390638
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18088052
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17288994
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15777988
76	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15148749
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12965725
78	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12488565
79	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10689930
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09946616
81	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09414058
82	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.08527161
83	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07583494
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01762255
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99765399
86	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98674103
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98127691
88	AR_20517297_ChIP-Seq_VCAP_Human	0.97409691
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97002006
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96806666
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96663939
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95045461
93	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94943185
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94306337
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92976300
96	* CDX2_22108803_ChIP-Seq_LS180_Human	0.92918554
97	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.91337152
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.91193996
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89355362
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.88796368

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	4.05805497
2	MP0000566_synostosis	3.86286517
3	MP0000569_abnormal_digit_pigmentation	3.64548339
4	MP0002102_abnormal_ear_morphology	3.32287411
5	MP0002938_white_spotting	3.25204325
6	MP0003136_yellow_coat_color	2.89774933
7	MP0001529_abnormal_vocalization	2.82895238
8	MP0003195_calcinosis	2.75347029
9	MP0003890_abnormal_embryonic-extraembry	2.56561408
10	MP0002234_abnormal_pharynx_morphology	2.43566073
11	MP0006292_abnormal_olfactory_placode	2.42129546
12	MP0005171_absent_coat_pigmentation	2.34945324
13	MP0002277_abnormal_respiratory_mucosa	2.30933501
14	MP0001293_anophthalmia	2.29623362
15	MP0003011_delayed_dark_adaptation	2.20247102
16	MP0001485_abnormal_pinna_reflex	2.02845064
17	MP0009379_abnormal_foot_pigmentation	1.89652312
18	MP0008877_abnormal_DNA_methylation	1.88932671
19	MP0006276_abnormal_autonomic_nervous	1.83824998
20	MP0000383_abnormal_hair_follicle	1.81632818
21	MP0006072_abnormal_retinal_apoptosis	1.79362485
22	MP0005551_abnormal_eye_electrophysiolog	1.74963150
23	MP0002653_abnormal_ependyma_morphology	1.66620493
24	MP0002837_dystrophic_cardiac_calcinosis	1.55820759
25	MP0003119_abnormal_digestive_system	1.53582899
26	MP0001324_abnormal_eye_pigmentation	1.51590805
27	MP0003646_muscle_fatigue	1.50970868
28	MP0000427_abnormal_hair_cycle	1.49573359
29	MP0005253_abnormal_eye_physiology	1.47643710
30	MP0008875_abnormal_xenobiotic_pharmacok	1.45856518
31	MP0004885_abnormal_endolymph	1.35824979
32	MP0004043_abnormal_pH_regulation	1.35672728
33	MP0003718_maternal_effect	1.35636607
34	MP0004142_abnormal_muscle_tone	1.32062454
35	MP0001968_abnormal_touch/_nociception	1.30671421
36	MP0002138_abnormal_hepatobiliary_system	1.30416910
37	MP0005386_behavior/neurological_phenoty	1.24944293
38	MP0004924_abnormal_behavior	1.24944293
39	MP0002736_abnormal_nociception_after	1.20851400
40	MP0004742_abnormal_vestibular_system	1.20499020
41	MP0000372_irregular_coat_pigmentation	1.20148934
42	MP0010094_abnormal_chromosome_stability	1.20105657
43	MP0003937_abnormal_limbs/digits/tail_de	1.18755806
44	MP0005084_abnormal_gallbladder_morpholo	1.18651265
45	MP0008058_abnormal_DNA_repair	1.18013998
46	MP0002272_abnormal_nervous_system	1.17478306
47	MP0002095_abnormal_skin_pigmentation	1.17208535
48	MP0005195_abnormal_posterior_eye	1.16950544
49	MP0002751_abnormal_autonomic_nervous	1.15038078
50	MP0000631_abnormal_neuroendocrine_gland	1.14137157
51	MP0003121_genomic_imprinting	1.13381865
52	MP0003122_maternal_imprinting	1.09980149
53	MP0005085_abnormal_gallbladder_physiolo	1.07707223
54	MP0001486_abnormal_startle_reflex	1.06955318
55	MP0003567_abnormal_fetal_cardiomyocyte	1.05903952
56	MP0001286_abnormal_eye_development	1.04959267
57	MP0005075_abnormal_melanosome_morpholog	1.03398002
58	MP0009745_abnormal_behavioral_response	1.03364397
59	MP0010386_abnormal_urinary_bladder	0.98575379
60	MP0001963_abnormal_hearing_physiology	0.96165523
61	MP0005167_abnormal_blood-brain_barrier	0.92380107
62	MP0000026_abnormal_inner_ear	0.92337363
63	MP0004133_heterotaxia	0.91371336
64	MP0009046_muscle_twitch	0.90885373
65	MP0010030_abnormal_orbit_morphology	0.90209682
66	MP0000647_abnormal_sebaceous_gland	0.89082894
67	MP0002282_abnormal_trachea_morphology	0.88078824
68	MP0003693_abnormal_embryo_hatching	0.87366676
69	MP0005391_vision/eye_phenotype	0.86282950
70	MP0000049_abnormal_middle_ear	0.85586528
71	MP0005410_abnormal_fertilization	0.84878357
72	MP0008872_abnormal_physiological_respon	0.84185451
73	MP0010678_abnormal_skin_adnexa	0.83879800
74	MP0002067_abnormal_sensory_capabilities	0.83749412
75	MP0002733_abnormal_thermal_nociception	0.83547443
76	MP0003938_abnormal_ear_development	0.83501172
77	MP0002064_seizures	0.82151488
78	MP0008057_abnormal_DNA_replication	0.80414857
79	MP0002752_abnormal_somatic_nervous	0.79811795
80	MP0002210_abnormal_sex_determination	0.79186671
81	MP0008961_abnormal_basal_metabolism	0.78980501
82	MP0002638_abnormal_pupillary_reflex	0.78742260
83	MP0003137_abnormal_impulse_conducting	0.77694973
84	MP0005646_abnormal_pituitary_gland	0.77189239
85	MP0002928_abnormal_bile_duct	0.77068684
86	MP0008789_abnormal_olfactory_epithelium	0.76875548
87	MP0002160_abnormal_reproductive_system	0.76392350
88	MP0003950_abnormal_plasma_membrane	0.76121320
89	MP0002735_abnormal_chemical_nociception	0.75932267
90	MP0002557_abnormal_social/conspecific_i	0.75477200
91	MP0001929_abnormal_gametogenesis	0.73889039
92	MP0000778_abnormal_nervous_system	0.73569141
93	MP0000538_abnormal_urinary_bladder	0.73108798
94	MP0003252_abnormal_bile_duct	0.72716572
95	MP0005174_abnormal_tail_pigmentation	0.72190590
96	MP0004215_abnormal_myocardial_fiber	0.70713656
97	MP0003787_abnormal_imprinting	0.69502868
98	MP0003698_abnormal_male_reproductive	0.68866133
99	MP0002109_abnormal_limb_morphology	0.67700776
100	MP0002697_abnormal_eye_size	0.67227688

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	3.97119698
2	Bilateral microphthalmos (HP:0007633)	3.69562711
3	Abnormality of the renal collecting system (HP:0004742)	3.66870667
4	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.38771207
5	Pancreatic cysts (HP:0001737)	3.32550663
6	Hypothermia (HP:0002045)	3.25180007
7	Reticulocytopenia (HP:0001896)	3.14050436
8	Hypoplastic nipples (HP:0002557)	3.13301856
9	Concave nail (HP:0001598)	3.08551877
10	Abnormality of midbrain morphology (HP:0002418)	3.05946951
11	Molar tooth sign on MRI (HP:0002419)	3.05946951
12	Absent thumb (HP:0009777)	3.04639602
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.03139354
14	True hermaphroditism (HP:0010459)	2.97556555
15	Meckel diverticulum (HP:0002245)	2.96984039
16	Birth length less than 3rd percentile (HP:0003561)	2.91788932
17	Abnormality of the ileum (HP:0001549)	2.90944493
18	Anophthalmia (HP:0000528)	2.89474095
19	Type II lissencephaly (HP:0007260)	2.88599470
20	Pancytopenia (HP:0001876)	2.86416164
21	Abnormality of the labia minora (HP:0012880)	2.80915507
22	Pancreatic fibrosis (HP:0100732)	2.80096699
23	3-Methylglutaconic aciduria (HP:0003535)	2.77788844
24	Limb hypertonia (HP:0002509)	2.75705153
25	Chromsome breakage (HP:0040012)	2.68724244
26	Focal motor seizures (HP:0011153)	2.65139383
27	Optic nerve hypoplasia (HP:0000609)	2.64511332
28	Congenital, generalized hypertrichosis (HP:0004540)	2.64471381
29	Nephronophthisis (HP:0000090)	2.58427691
30	Abnormality of chromosome stability (HP:0003220)	2.57004714
31	Congenital stationary night blindness (HP:0007642)	2.56138849
32	Septo-optic dysplasia (HP:0100842)	2.52652728
33	Clubbing of toes (HP:0100760)	2.51427451
34	Duodenal stenosis (HP:0100867)	2.49438571
35	Small intestinal stenosis (HP:0012848)	2.49438571
36	Abnormality of the preputium (HP:0100587)	2.49313165
37	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.48795036
38	Renal hypoplasia (HP:0000089)	2.47798349
39	Congenital hepatic fibrosis (HP:0002612)	2.45576402
40	Hyperventilation (HP:0002883)	2.45188894
41	Ectopic kidney (HP:0000086)	2.43495538
42	Inability to walk (HP:0002540)	2.42550198
43	Limb dystonia (HP:0002451)	2.40966501
44	Abnormality of the carotid arteries (HP:0005344)	2.39891439
45	Abnormality of the pons (HP:0007361)	2.35136398
46	Wide intermamillary distance (HP:0006610)	2.33518949
47	Cerebellar dysplasia (HP:0007033)	2.28159619
48	Absent radius (HP:0003974)	2.23702809
49	Constricted visual fields (HP:0001133)	2.22632721
50	Abnormality of the duodenum (HP:0002246)	2.21111756
51	Absent forearm bone (HP:0003953)	2.20854366
52	Aplasia involving forearm bones (HP:0009822)	2.20854366
53	Dialeptic seizures (HP:0011146)	2.18685500
54	Triphalangeal thumb (HP:0001199)	2.17772042
55	Hypoplasia of the pons (HP:0012110)	2.17281954
56	Patellar aplasia (HP:0006443)	2.16138732
57	Increased CSF lactate (HP:0002490)	2.15780098
58	Abnormality of the renal medulla (HP:0100957)	2.15575785
59	Male pseudohermaphroditism (HP:0000037)	2.15031135
60	Retinal dysplasia (HP:0007973)	2.14644606
61	Chronic hepatic failure (HP:0100626)	2.11871767
62	Abnormality of the renal cortex (HP:0011035)	2.11667409
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11359926
64	Maternal diabetes (HP:0009800)	2.10347945
65	Abnormality of DNA repair (HP:0003254)	2.08030727
66	Bile duct proliferation (HP:0001408)	2.07677361
67	Abnormal biliary tract physiology (HP:0012439)	2.07677361
68	Progressive inability to walk (HP:0002505)	2.07201367
69	Sclerocornea (HP:0000647)	2.03383761
70	Mitochondrial inheritance (HP:0001427)	2.02608507
71	Small hand (HP:0200055)	2.01841859
72	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01669584
73	Absent/shortened dynein arms (HP:0200106)	2.01669584
74	Midline defect of the nose (HP:0004122)	2.01013699
75	Bifid scrotum (HP:0000048)	1.99887151
76	Aplasia/Hypoplasia of the patella (HP:0006498)	1.98245157
77	Acute necrotizing encephalopathy (HP:0006965)	1.96271639
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95530585
79	Increased hepatocellular lipid droplets (HP:0006565)	1.94767107
80	Abnormal pupillary function (HP:0007686)	1.94715457
81	Progressive microcephaly (HP:0000253)	1.94487376
82	Anencephaly (HP:0002323)	1.93594096
83	Acute encephalopathy (HP:0006846)	1.93007621
84	Bone marrow hypocellularity (HP:0005528)	1.92104871
85	Partial agenesis of the corpus callosum (HP:0001338)	1.92032703
86	Abnormal number of erythroid precursors (HP:0012131)	1.91051036
87	Attenuation of retinal blood vessels (HP:0007843)	1.90342316
88	Sloping forehead (HP:0000340)	1.86165669
89	Disproportionate short-trunk short stature (HP:0003521)	1.86029307
90	Volvulus (HP:0002580)	1.85554586
91	Lissencephaly (HP:0001339)	1.85330591
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.83583660
93	Abnormality of alanine metabolism (HP:0010916)	1.83583660
94	Hyperalaninemia (HP:0003348)	1.83583660
95	Lipid accumulation in hepatocytes (HP:0006561)	1.82846745
96	Pendular nystagmus (HP:0012043)	1.82826674
97	Colon cancer (HP:0003003)	1.81389858
98	Horseshoe kidney (HP:0000085)	1.80056180
99	Hydroxyprolinuria (HP:0003080)	1.79508951
100	Abnormality of proline metabolism (HP:0010907)	1.79508951

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.70364759
2	FRK	3.80550673
3	ACVR1B	3.26651410
4	BMPR1B	3.23744489
5	VRK2	2.70916648
6	ADRBK2	2.59803601
7	WNK3	2.56137598
8	CCNB1	2.48004068
9	INSRR	2.22803515
10	PASK	2.15861752
11	BRSK2	2.05717968
12	VRK1	2.01167314
13	MKNK1	1.92376930
14	MAPK13	1.88766698
15	STK39	1.88092874
16	MKNK2	1.84674820
17	TGFBR1	1.80119937
18	WNK4	1.77831846
19	GRK1	1.75129562
20	PINK1	1.61783993
21	KIT	1.51217258
22	TLK1	1.45826697
23	TXK	1.44915344
24	CAMKK2	1.44205858
25	MAP4K2	1.41937408
26	WEE1	1.41524978
27	OXSR1	1.38430866
28	GRK7	1.31110226
29	SRPK1	1.29525654
30	ADRBK1	1.27409612
31	MAPK15	1.27069415
32	TIE1	1.26991759
33	DYRK2	1.26572223
34	PRKD3	1.18918478
35	BUB1	1.13422302
36	PLK3	1.12549594
37	NUAK1	1.08878228
38	PLK4	1.08789750
39	CASK	1.05078026
40	PNCK	1.03686519
41	LATS1	1.00666573
42	NTRK2	1.00176244
43	TSSK6	0.99099885
44	PAK3	0.93417782
45	CHEK2	0.89344644
46	TTK	0.88735873
47	STK38L	0.88676742
48	TAOK3	0.88595988
49	STK16	0.88044519
50	DAPK2	0.86375585
51	MAP3K4	0.86174992
52	BCKDK	0.78308328
53	CSNK1G1	0.77866834
54	PRKCG	0.77688630
55	TEC	0.77111607
56	CSNK1G3	0.69786275
57	TRIM28	0.69276693
58	NME1	0.67728193
59	CSNK1G2	0.65253315
60	TNIK	0.63308994
61	PIK3CA	0.62181539
62	EPHB2	0.61085943
63	RPS6KA5	0.59812286
64	CAMKK1	0.58962363
65	PRKCE	0.58480545
66	CSNK1A1L	0.57695574
67	PLK1	0.57252376
68	MUSK	0.56996984
69	OBSCN	0.54799012
70	BCR	0.54284108
71	ATR	0.54225157
72	FLT3	0.53956414
73	CDC7	0.51607468
74	EIF2AK2	0.49666924
75	CDK3	0.49221357
76	MARK1	0.46653845
77	GRK5	0.46353249
78	MAP2K7	0.43309529
79	ATM	0.42800787
80	CSNK1D	0.42796819
81	PRKCQ	0.40265602
82	CHUK	0.37680947
83	TGFBR2	0.37396187
84	ERBB2	0.37152793
85	PTK2B	0.36787597
86	SYK	0.35448790
87	CSNK1A1	0.34870869
88	MST4	0.34098136
89	PRKACA	0.31945278
90	IKBKB	0.31463242
91	CSNK2A1	0.31064341
92	PLK2	0.30962891
93	STK11	0.30184498
94	AURKB	0.29716082
95	MAPKAPK5	0.27548131
96	PHKG2	0.25959776
97	PHKG1	0.25959776
98	PKN1	0.25937478
99	STK3	0.25604114
100	STK10	0.25051769

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Histidine metabolism_Homo sapiens_hsa00340	3.48813340
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.23171830
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.80932472
4	RNA polymerase_Homo sapiens_hsa03020	2.57215129
5	beta-Alanine metabolism_Homo sapiens_hsa00410	2.39864335
6	Ribosome_Homo sapiens_hsa03010	2.24155297
7	Protein export_Homo sapiens_hsa03060	2.12411513
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.12034794
9	Parkinsons disease_Homo sapiens_hsa05012	2.11416279
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.97607193
11	Basal transcription factors_Homo sapiens_hsa03022	1.96863370
12	One carbon pool by folate_Homo sapiens_hsa00670	1.94094515
13	Homologous recombination_Homo sapiens_hsa03440	1.87273094
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.84229459
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77569302
16	Butanoate metabolism_Homo sapiens_hsa00650	1.73144473
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.70831464
18	Propanoate metabolism_Homo sapiens_hsa00640	1.68436797
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.64726051
20	Huntingtons disease_Homo sapiens_hsa05016	1.62660310
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56088061
22	Phototransduction_Homo sapiens_hsa04744	1.55111248
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50241926
24	Spliceosome_Homo sapiens_hsa03040	1.50228231
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.47880074
26	Taste transduction_Homo sapiens_hsa04742	1.44228465
27	Nicotine addiction_Homo sapiens_hsa05033	1.43765553
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.41780150
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39884573
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.38933447
31	Alzheimers disease_Homo sapiens_hsa05010	1.38457070
32	Base excision repair_Homo sapiens_hsa03410	1.28971853
33	Purine metabolism_Homo sapiens_hsa00230	1.26015652
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24338574
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.21885108
36	Mismatch repair_Homo sapiens_hsa03430	1.20137030
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20099386
38	Sulfur metabolism_Homo sapiens_hsa00920	1.19777735
39	Cell cycle_Homo sapiens_hsa04110	1.17590965
40	Proteasome_Homo sapiens_hsa03050	1.13211710
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11765183
42	DNA replication_Homo sapiens_hsa03030	1.11405491
43	RNA degradation_Homo sapiens_hsa03018	1.10941018
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08844866
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.08470732
46	Olfactory transduction_Homo sapiens_hsa04740	1.07651682
47	Arginine and proline metabolism_Homo sapiens_hsa00330	1.07639659
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01896449
49	GABAergic synapse_Homo sapiens_hsa04727	0.99360872
50	Peroxisome_Homo sapiens_hsa04146	0.98274054
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.98117346
52	Caffeine metabolism_Homo sapiens_hsa00232	0.97236590
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95772937
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.95361552
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.94211202
56	Retinol metabolism_Homo sapiens_hsa00830	0.92177823
57	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.91026893
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.90915759
59	RNA transport_Homo sapiens_hsa03013	0.85767977
60	Regulation of autophagy_Homo sapiens_hsa04140	0.85190426
61	p53 signaling pathway_Homo sapiens_hsa04115	0.84383560
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83948554
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80922959
64	Oocyte meiosis_Homo sapiens_hsa04114	0.80796209
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80668572
66	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.79989542
67	Morphine addiction_Homo sapiens_hsa05032	0.76979004
68	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76974104
69	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.76949568
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74067999
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71955597
72	Metabolic pathways_Homo sapiens_hsa01100	0.71487842
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.70733413
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.68280010
75	Serotonergic synapse_Homo sapiens_hsa04726	0.63574858
76	ABC transporters_Homo sapiens_hsa02010	0.62664554
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62069368
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61635867
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61039484
80	Phenylalanine metabolism_Homo sapiens_hsa00360	0.60091190
81	Primary immunodeficiency_Homo sapiens_hsa05340	0.58657028
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56579121
83	Non-homologous end-joining_Homo sapiens_hsa03450	0.55109208
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52739725
85	Insulin secretion_Homo sapiens_hsa04911	0.49425982
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48954344
87	Asthma_Homo sapiens_hsa05310	0.47602187
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.45540883
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43400377
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42194061
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41629552
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.41384882
93	Cocaine addiction_Homo sapiens_hsa05030	0.39222718
94	Circadian entrainment_Homo sapiens_hsa04713	0.38139459
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35339441
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.34370888
97	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.34304165
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34222811
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.31620883
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.31552604

ZNF765

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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