ZNF766

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.97900782
2negative regulation of DNA-dependent DNA replication (GO:2000104)4.10172955
3negative regulation of telomere maintenance (GO:0032205)4.04595249
4fucose catabolic process (GO:0019317)3.92723333
5L-fucose metabolic process (GO:0042354)3.92723333
6L-fucose catabolic process (GO:0042355)3.92723333
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.78933484
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.78933484
9regulation of translation, ncRNA-mediated (GO:0045974)3.78933484
10renal system development (GO:0072001)3.70909395
11response to pheromone (GO:0019236)3.70438643
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.54431601
13spliceosomal complex assembly (GO:0000245)3.51613579
14recombinational repair (GO:0000725)3.47168352
15double-strand break repair via homologous recombination (GO:0000724)3.46904242
16water-soluble vitamin biosynthetic process (GO:0042364)3.45285537
17kidney morphogenesis (GO:0060993)3.41779521
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.40976143
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.40976143
20DNA double-strand break processing (GO:0000729)3.31235458
21regulation of meiosis I (GO:0060631)3.29168856
22reciprocal meiotic recombination (GO:0007131)3.26942481
23reciprocal DNA recombination (GO:0035825)3.26942481
24nonmotile primary cilium assembly (GO:0035058)3.26752507
25neural tube formation (GO:0001841)3.24606112
26DNA deamination (GO:0045006)3.17477336
27regulation of posttranscriptional gene silencing (GO:0060147)3.14995589
28regulation of gene silencing by miRNA (GO:0060964)3.14995589
29regulation of gene silencing by RNA (GO:0060966)3.14995589
30replication fork processing (GO:0031297)3.14483661
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11948541
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.04443187
33regulation of telomere maintenance (GO:0032204)3.03048022
34negative regulation of transcription regulatory region DNA binding (GO:2000678)3.02098705
35cellular ketone body metabolic process (GO:0046950)3.00928926
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.00416996
37NADH dehydrogenase complex assembly (GO:0010257)3.00416996
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00416996
39protein K6-linked ubiquitination (GO:0085020)2.99899465
40protein complex biogenesis (GO:0070271)2.96114077
41respiratory chain complex IV assembly (GO:0008535)2.93288970
42cornea development in camera-type eye (GO:0061303)2.93012838
43kynurenine metabolic process (GO:0070189)2.87998364
44mitochondrial respiratory chain complex assembly (GO:0033108)2.87733942
45maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87443209
46forebrain neuron differentiation (GO:0021879)2.85757286
47tryptophan catabolic process (GO:0006569)2.84785502
48indole-containing compound catabolic process (GO:0042436)2.84785502
49indolalkylamine catabolic process (GO:0046218)2.84785502
50cilium organization (GO:0044782)2.83018164
51protein localization to cilium (GO:0061512)2.82786200
52male meiosis I (GO:0007141)2.82696914
53epithelial cilium movement (GO:0003351)2.80419427
54indolalkylamine metabolic process (GO:0006586)2.79787514
55protein-cofactor linkage (GO:0018065)2.79172015
56cilium assembly (GO:0042384)2.78905271
57piRNA metabolic process (GO:0034587)2.78812647
58meiotic chromosome segregation (GO:0045132)2.76254544
59nucleotide-excision repair, DNA gap filling (GO:0006297)2.76126155
60DNA-dependent DNA replication (GO:0006261)2.74041528
61ketone body metabolic process (GO:1902224)2.70397678
62pyrimidine nucleobase catabolic process (GO:0006208)2.67502858
63cell proliferation in forebrain (GO:0021846)2.66209184
64platelet dense granule organization (GO:0060155)2.65709469
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64130534
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64101704
67intracellular protein transmembrane transport (GO:0065002)2.63597804
68somite development (GO:0061053)2.62836627
69adenosine metabolic process (GO:0046085)2.61069955
70limb bud formation (GO:0060174)2.60989682
71multicellular organismal aging (GO:0010259)2.60900176
72ATP synthesis coupled proton transport (GO:0015986)2.59316198
73energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59316198
74cytochrome complex assembly (GO:0017004)2.59112964
75intra-S DNA damage checkpoint (GO:0031573)2.56316384
76gamma-aminobutyric acid transport (GO:0015812)2.56228580
77regulation of mitotic spindle checkpoint (GO:1903504)2.55675664
78regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55675664
79regulation of mesoderm development (GO:2000380)2.55546482
80positive regulation of oligodendrocyte differentiation (GO:0048714)2.54679089
81sulfation (GO:0051923)2.53905448
82smoothened signaling pathway (GO:0007224)2.53348894
83telomere maintenance via telomerase (GO:0007004)2.53224180
84mismatch repair (GO:0006298)2.52970494
85preassembly of GPI anchor in ER membrane (GO:0016254)2.51751528
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51259898
87regulation of double-strand break repair via homologous recombination (GO:0010569)2.51253802
88tryptophan metabolic process (GO:0006568)2.51160724
89centriole replication (GO:0007099)2.49547968
90cilium morphogenesis (GO:0060271)2.48530842
91retinal cone cell development (GO:0046549)2.47890408
92neuronal action potential (GO:0019228)2.46504508
93DNA demethylation (GO:0080111)2.44303291
94presynaptic membrane assembly (GO:0097105)2.42602549
95regulation of hippo signaling (GO:0035330)2.41015028
96detection of light stimulus involved in visual perception (GO:0050908)2.38977923
97detection of light stimulus involved in sensory perception (GO:0050962)2.38977923
98atrial cardiac muscle cell action potential (GO:0086014)2.38778427
99behavioral response to ethanol (GO:0048149)2.38441115
100photoreceptor cell development (GO:0042461)2.36445192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.29067983
2EZH2_22144423_ChIP-Seq_EOC_Human3.37720548
3VDR_22108803_ChIP-Seq_LS180_Human3.26487699
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01576437
5GBX2_23144817_ChIP-Seq_PC3_Human2.63523570
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46291555
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43699695
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36246663
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.36203328
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26001186
11FUS_26573619_Chip-Seq_HEK293_Human2.25125847
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.24015700
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22955755
14EWS_26573619_Chip-Seq_HEK293_Human2.21818845
15IGF1R_20145208_ChIP-Seq_DFB_Human2.14020659
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10441634
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09921940
18P300_19829295_ChIP-Seq_ESCs_Human2.01053268
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94762566
20TAF15_26573619_Chip-Seq_HEK293_Human1.92972554
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.91832582
22ER_23166858_ChIP-Seq_MCF-7_Human1.91669615
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88769604
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.82844743
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80734776
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79813399
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74530443
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73291458
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71365632
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71090751
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.69960314
32MYC_18940864_ChIP-ChIP_HL60_Human1.67145872
33IRF1_19129219_ChIP-ChIP_H3396_Human1.65701503
34AR_21572438_ChIP-Seq_LNCaP_Human1.60628699
35BCAT_22108803_ChIP-Seq_LS180_Human1.59606991
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58062657
37CBP_20019798_ChIP-Seq_JUKART_Human1.58062657
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56927436
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53619297
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51942654
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50824251
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.50443173
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49674337
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49674337
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49289378
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49201124
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.48677269
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48013865
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45731734
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45436716
51AR_25329375_ChIP-Seq_VCAP_Human1.43359566
52ELK1_19687146_ChIP-ChIP_HELA_Human1.43078194
53TP53_22573176_ChIP-Seq_HFKS_Human1.41363629
54SMAD4_21799915_ChIP-Seq_A2780_Human1.36161214
55* STAT3_23295773_ChIP-Seq_U87_Human1.35543468
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35112537
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33422952
58TCF4_23295773_ChIP-Seq_U87_Human1.33209889
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30383951
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30159080
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29460655
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28648520
63REST_21632747_ChIP-Seq_MESCs_Mouse1.28536101
64SOX2_19829295_ChIP-Seq_ESCs_Human1.28240473
65NANOG_19829295_ChIP-Seq_ESCs_Human1.28240473
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.27825813
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25640264
68RNF2_27304074_Chip-Seq_NSC_Mouse1.24136443
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22520788
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.22348018
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.21015639
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.19760605
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16962508
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.16962508
75* RUNX2_22187159_ChIP-Seq_PCA_Human1.15404992
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14777692
77TCF4_22108803_ChIP-Seq_LS180_Human1.12948826
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.12810247
79AR_20517297_ChIP-Seq_VCAP_Human1.12132566
80VDR_23849224_ChIP-Seq_CD4+_Human1.11570046
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11091453
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09189085
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.08689869
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07431530
85HOXB7_26014856_ChIP-Seq_BT474_Human1.07158378
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06529698
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05630705
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05571611
89NCOR_22424771_ChIP-Seq_293T_Human1.03339624
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01407039
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.00469336
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98998217
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98954709
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.98650077
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97700371
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95622655
97CDX2_22108803_ChIP-Seq_LS180_Human0.95083012
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.94474939
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.93936112
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.92903226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.98528026
2MP0006292_abnormal_olfactory_placode3.52090053
3MP0002938_white_spotting2.42920841
4MP0003195_calcinosis2.33775950
5MP0002102_abnormal_ear_morphology2.31033063
6MP0003136_yellow_coat_color2.26357795
7MP0000566_synostosis2.25649357
8MP0003787_abnormal_imprinting2.14334347
9MP0008058_abnormal_DNA_repair2.13283526
10MP0000569_abnormal_digit_pigmentation2.06064736
11MP0006276_abnormal_autonomic_nervous2.04434318
12MP0008872_abnormal_physiological_respon1.90538824
13MP0003646_muscle_fatigue1.89434061
14MP0004147_increased_porphyrin_level1.86502290
15MP0004133_heterotaxia1.84525852
16MP0000372_irregular_coat_pigmentation1.82433561
17MP0005551_abnormal_eye_electrophysiolog1.80625099
18MP0001986_abnormal_taste_sensitivity1.76351922
19MP0002653_abnormal_ependyma_morphology1.72989171
20MP0003880_abnormal_central_pattern1.70564136
21MP0001968_abnormal_touch/_nociception1.66780577
22MP0003890_abnormal_embryonic-extraembry1.66268030
23MP0006072_abnormal_retinal_apoptosis1.63449515
24MP0008995_early_reproductive_senescence1.63207447
25MP0004043_abnormal_pH_regulation1.60100044
26MP0000631_abnormal_neuroendocrine_gland1.57554955
27MP0004142_abnormal_muscle_tone1.54403493
28MP0005645_abnormal_hypothalamus_physiol1.53578119
29MP0009046_muscle_twitch1.50143345
30MP0001485_abnormal_pinna_reflex1.49998563
31MP0003121_genomic_imprinting1.49488322
32MP0009745_abnormal_behavioral_response1.49141039
33MP0002638_abnormal_pupillary_reflex1.48697770
34MP0008789_abnormal_olfactory_epithelium1.48670941
35MP0000427_abnormal_hair_cycle1.47992263
36MP0002736_abnormal_nociception_after1.45827961
37MP0004885_abnormal_endolymph1.43678520
38MP0005253_abnormal_eye_physiology1.43177987
39MP0008875_abnormal_xenobiotic_pharmacok1.39303749
40MP0002234_abnormal_pharynx_morphology1.36398681
41MP0001293_anophthalmia1.33956275
42MP0000778_abnormal_nervous_system1.33880784
43MP0002735_abnormal_chemical_nociception1.32287544
44MP0005075_abnormal_melanosome_morpholog1.31912162
45MP0001984_abnormal_olfaction1.30723736
46MP0002272_abnormal_nervous_system1.30607864
47MP0001188_hyperpigmentation1.30320709
48MP0000383_abnormal_hair_follicle1.28906183
49MP0003011_delayed_dark_adaptation1.26537508
50MP0001501_abnormal_sleep_pattern1.26524114
51MP0003718_maternal_effect1.22766843
52MP0010094_abnormal_chromosome_stability1.21607267
53MP0002837_dystrophic_cardiac_calcinosis1.21016550
54MP0003119_abnormal_digestive_system1.20695017
55MP0005646_abnormal_pituitary_gland1.20064449
56MP0005499_abnormal_olfactory_system1.18201418
57MP0005394_taste/olfaction_phenotype1.18201418
58MP0001529_abnormal_vocalization1.15197654
59MP0003122_maternal_imprinting1.15174668
60MP0002095_abnormal_skin_pigmentation1.11632477
61MP0002928_abnormal_bile_duct1.10976122
62MP0001486_abnormal_startle_reflex1.10305329
63MP0005084_abnormal_gallbladder_morpholo1.09466949
64MP0002557_abnormal_social/conspecific_i1.07729387
65MP0005195_abnormal_posterior_eye1.05709810
66MP0004742_abnormal_vestibular_system1.05107377
67MP0005171_absent_coat_pigmentation1.04651221
68MP0002572_abnormal_emotion/affect_behav1.03741641
69MP0000647_abnormal_sebaceous_gland1.02457624
70MP0002751_abnormal_autonomic_nervous1.00922150
71MP0003938_abnormal_ear_development0.99760912
72MP0002184_abnormal_innervation0.99728936
73MP0008057_abnormal_DNA_replication0.98948719
74MP0010030_abnormal_orbit_morphology0.97331724
75MP0003937_abnormal_limbs/digits/tail_de0.97269473
76MP0003567_abnormal_fetal_cardiomyocyte0.96955197
77MP0005389_reproductive_system_phenotype0.96862162
78MP0005174_abnormal_tail_pigmentation0.95325014
79MP0005187_abnormal_penis_morphology0.95271032
80MP0002160_abnormal_reproductive_system0.95148475
81MP0002277_abnormal_respiratory_mucosa0.92169413
82MP0002064_seizures0.91700932
83MP0000049_abnormal_middle_ear0.90885521
84MP0004145_abnormal_muscle_electrophysio0.90884374
85MP0002752_abnormal_somatic_nervous0.90871034
86MP0002067_abnormal_sensory_capabilities0.89965431
87MP0003283_abnormal_digestive_organ0.89194036
88MP0000026_abnormal_inner_ear0.87425656
89MP0001324_abnormal_eye_pigmentation0.87237174
90MP0002063_abnormal_learning/memory/cond0.87215880
91MP0004924_abnormal_behavior0.86295831
92MP0005386_behavior/neurological_phenoty0.86295831
93MP0004215_abnormal_myocardial_fiber0.86284905
94MP0001919_abnormal_reproductive_system0.86195175
95MP0005423_abnormal_somatic_nervous0.85825411
96MP0003137_abnormal_impulse_conducting0.85583242
97MP0005410_abnormal_fertilization0.84901711
98MP0001970_abnormal_pain_threshold0.84692532
99MP0003698_abnormal_male_reproductive0.83808680
100MP0002210_abnormal_sex_determination0.82882650

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)5.03061752
2Birth length less than 3rd percentile (HP:0003561)4.97121770
3Pancreatic cysts (HP:0001737)4.16872191
4Cystic liver disease (HP:0006706)3.92411198
5Pancreatic fibrosis (HP:0100732)3.89680368
6True hermaphroditism (HP:0010459)3.78943949
7Molar tooth sign on MRI (HP:0002419)3.62661440
8Abnormality of midbrain morphology (HP:0002418)3.62661440
9Progressive cerebellar ataxia (HP:0002073)3.33012812
10Nephronophthisis (HP:0000090)3.24485089
11Patellar aplasia (HP:0006443)3.18975029
12Congenital stationary night blindness (HP:0007642)3.12053048
13Aplasia/Hypoplasia of the patella (HP:0006498)2.95357506
14Breast hypoplasia (HP:0003187)2.83053004
15Colon cancer (HP:0003003)2.76216904
16Chromsome breakage (HP:0040012)2.73165177
17Abnormality of the renal medulla (HP:0100957)2.71930208
18Aplasia/Hypoplasia of the sternum (HP:0006714)2.64319550
19Medial flaring of the eyebrow (HP:0010747)2.63386220
20Hyperventilation (HP:0002883)2.62416216
21Type II lissencephaly (HP:0007260)2.48558925
22Inability to walk (HP:0002540)2.43589836
23Aplasia/Hypoplasia of the tongue (HP:0010295)2.38902141
24Chronic hepatic failure (HP:0100626)2.37646019
25Hypoplastic labia majora (HP:0000059)2.33445220
26Pendular nystagmus (HP:0012043)2.31031645
27Esophageal atresia (HP:0002032)2.30771520
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30391748
29Abnormality of alanine metabolism (HP:0010916)2.30391748
30Hyperalaninemia (HP:0003348)2.30391748
31Febrile seizures (HP:0002373)2.30058800
32Abnormality of the renal cortex (HP:0011035)2.30000787
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.28774505
34Gastrointestinal atresia (HP:0002589)2.26458394
35Attenuation of retinal blood vessels (HP:0007843)2.22951662
36Sclerocornea (HP:0000647)2.20675948
37Abolished electroretinogram (ERG) (HP:0000550)2.19221075
38Abnormality of the labia majora (HP:0012881)2.17927087
39Anencephaly (HP:0002323)2.16524668
40Small hand (HP:0200055)2.14534738
41Optic nerve hypoplasia (HP:0000609)2.14517414
42Gait imbalance (HP:0002141)2.13453120
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10296792
44Abnormality of cochlea (HP:0000375)2.10129510
45Progressive inability to walk (HP:0002505)2.09754538
46Large for gestational age (HP:0001520)2.08763600
47Congenital primary aphakia (HP:0007707)2.08207451
48Triphalangeal thumb (HP:0001199)2.07688776
49Labial hypoplasia (HP:0000066)2.07249929
50Abnormality of chromosome stability (HP:0003220)2.07140658
51Methylmalonic acidemia (HP:0002912)2.06571035
52Protruding tongue (HP:0010808)2.05976580
53Congenital, generalized hypertrichosis (HP:0004540)2.04377115
54Lissencephaly (HP:0001339)2.03629470
55Furrowed tongue (HP:0000221)2.01097287
56Tubular atrophy (HP:0000092)2.00875313
57Broad-based gait (HP:0002136)2.00703536
58Morphological abnormality of the inner ear (HP:0011390)2.00076383
59Meckel diverticulum (HP:0002245)1.99222340
60Concave nail (HP:0001598)1.97381692
61Nephrogenic diabetes insipidus (HP:0009806)1.97296600
62Male pseudohermaphroditism (HP:0000037)1.96550281
63Genital tract atresia (HP:0001827)1.95970252
64Dandy-Walker malformation (HP:0001305)1.95434842
65Stomach cancer (HP:0012126)1.94378428
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94368836
67Abnormality of the ileum (HP:0001549)1.93698221
68Oligodactyly (hands) (HP:0001180)1.93476387
69Hypoplastic female external genitalia (HP:0012815)1.92738584
70Postaxial foot polydactyly (HP:0001830)1.91691938
71Shawl scrotum (HP:0000049)1.90594191
72Congenital hepatic fibrosis (HP:0002612)1.90042506
73Bile duct proliferation (HP:0001408)1.88955035
74Abnormal biliary tract physiology (HP:0012439)1.88955035
75Hemiparesis (HP:0001269)1.88313345
76Intestinal atresia (HP:0011100)1.87584997
77Rib fusion (HP:0000902)1.86222260
78Vaginal atresia (HP:0000148)1.86090054
79Abnormality of the pons (HP:0007361)1.85898215
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.83388190
81Sloping forehead (HP:0000340)1.81594870
82Chorioretinal atrophy (HP:0000533)1.79147343
83Gaze-evoked nystagmus (HP:0000640)1.78454881
84Bony spicule pigmentary retinopathy (HP:0007737)1.75367409
85Abnormality of the renal collecting system (HP:0004742)1.75021199
86Preaxial hand polydactyly (HP:0001177)1.74141378
87Decreased central vision (HP:0007663)1.73831549
88Epileptic encephalopathy (HP:0200134)1.73735758
89Small intestinal stenosis (HP:0012848)1.73586361
90Duodenal stenosis (HP:0100867)1.73586361
91Abnormal drinking behavior (HP:0030082)1.73503421
92Polydipsia (HP:0001959)1.73503421
93Abnormal rod and cone electroretinograms (HP:0008323)1.71826661
94Acute necrotizing encephalopathy (HP:0006965)1.70547066
95Supernumerary spleens (HP:0009799)1.70236393
96Abnormal respiratory motile cilium morphology (HP:0005938)1.68959906
97Abnormal respiratory epithelium morphology (HP:0012253)1.68959906
98Abnormality of the duodenum (HP:0002246)1.68857065
99Oligodactyly (HP:0012165)1.68366034
100Fair hair (HP:0002286)1.68020394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.97037412
2ZAK3.25555455
3BMPR1B3.11466036
4ADRBK23.08827171
5WNK33.06191786
6ACVR1B2.82113545
7WNK42.26290714
8CASK2.24650924
9BRSK22.23979337
10TAOK32.23722058
11INSRR2.19609610
12NUAK12.09157758
13GRK12.04136378
14PNCK2.01383327
15MAP4K21.96791984
16DAPK21.74289612
17MAPK131.71844602
18TLK11.70947004
19TNIK1.66677800
20STK38L1.65067642
21WEE11.61304347
22MAP3K41.55895426
23MKNK21.52310639
24PINK11.51061139
25PLK41.49418152
26PAK31.45279154
27TRIM281.43566869
28AKT31.30985565
29TGFBR11.25894436
30OXSR11.24222737
31SGK21.15693786
32DYRK21.12499263
33MARK11.07667176
34STK391.03287242
35ADRBK10.96169918
36MUSK0.95386574
37MKNK10.91856352
38SGK2230.86177621
39SGK4940.86177621
40VRK10.84783263
41TXK0.84091476
42PLK30.83112677
43CDC70.82053687
44ATR0.81747973
45PRKCG0.80876649
46BCKDK0.80564881
47NME10.79004911
48PLK10.76860912
49MAP2K70.76078567
50ERBB30.75175178
51NTRK20.74870711
52PAK60.73945285
53FGFR20.73506867
54KSR10.68289183
55TSSK60.67007812
56MAPK150.66911694
57EPHB20.65924075
58CSNK1G20.65636898
59SRPK10.65383644
60DYRK30.64247090
61ATM0.60943721
62PRKCE0.60042379
63CSNK1G10.58118478
64NEK20.57189765
65NLK0.56926366
66BRSK10.56582946
67BCR0.55557713
68PASK0.54676021
69PTK2B0.53196551
70CAMKK20.52812185
71TIE10.51483831
72NTRK30.49351842
73CSNK1G30.48178273
74PLK20.47918302
75TAF10.46315047
76TEC0.45966077
77PKN10.43719635
78CHEK20.42282741
79PIK3CA0.42163600
80CSNK1A1L0.41914942
81CHUK0.41826360
82RPS6KA50.39485738
83CAMK1G0.39333234
84CAMK1D0.39094041
85PRKCQ0.38907740
86CAMK2A0.38132570
87PRKACA0.37249643
88CSNK1D0.35970965
89PRKDC0.35732309
90TTK0.35649451
91MINK10.35418936
92BUB10.34668487
93OBSCN0.33833802
94STK160.33490669
95CAMK10.33323818
96KIT0.31937353
97CSNK1A10.31416777
98PRKAA10.30921501
99VRK20.30375442
100STK30.30194621

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034404.10235247
2Protein export_Homo sapiens_hsa030603.82111967
3Fanconi anemia pathway_Homo sapiens_hsa034602.80929560
4Mismatch repair_Homo sapiens_hsa034302.68676771
5Non-homologous end-joining_Homo sapiens_hsa034502.34497619
6Phototransduction_Homo sapiens_hsa047442.33083416
7Linoleic acid metabolism_Homo sapiens_hsa005912.28899017
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28206223
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10149116
10Selenocompound metabolism_Homo sapiens_hsa004502.08746382
11Oxidative phosphorylation_Homo sapiens_hsa001902.01658838
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00122029
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96089959
14Nicotine addiction_Homo sapiens_hsa050331.93638830
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90906896
16Butanoate metabolism_Homo sapiens_hsa006501.89769605
17RNA polymerase_Homo sapiens_hsa030201.87341030
18Caffeine metabolism_Homo sapiens_hsa002321.85170062
19Basal transcription factors_Homo sapiens_hsa030221.85150118
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82349372
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.73121883
22Nitrogen metabolism_Homo sapiens_hsa009101.72978998
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67134205
24Propanoate metabolism_Homo sapiens_hsa006401.63401548
25Parkinsons disease_Homo sapiens_hsa050121.59245169
26Ether lipid metabolism_Homo sapiens_hsa005651.49123322
27Nucleotide excision repair_Homo sapiens_hsa034201.48366543
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44924472
29RNA degradation_Homo sapiens_hsa030181.44047092
30DNA replication_Homo sapiens_hsa030301.40968803
31Tryptophan metabolism_Homo sapiens_hsa003801.34460331
32ABC transporters_Homo sapiens_hsa020101.29091248
33Taste transduction_Homo sapiens_hsa047421.19073268
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18370475
35Ribosome_Homo sapiens_hsa030101.16295610
36Huntingtons disease_Homo sapiens_hsa050161.13048709
37Olfactory transduction_Homo sapiens_hsa047401.12270860
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10438952
39Steroid biosynthesis_Homo sapiens_hsa001001.07626862
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04457906
41Morphine addiction_Homo sapiens_hsa050321.02970940
42Peroxisome_Homo sapiens_hsa041460.99227871
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97174982
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.96035120
45One carbon pool by folate_Homo sapiens_hsa006700.89425044
46Alzheimers disease_Homo sapiens_hsa050100.88764710
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88529931
48Serotonergic synapse_Homo sapiens_hsa047260.88112756
49Proteasome_Homo sapiens_hsa030500.88069592
50Purine metabolism_Homo sapiens_hsa002300.85248598
51Cardiac muscle contraction_Homo sapiens_hsa042600.84680475
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.83305002
53Circadian entrainment_Homo sapiens_hsa047130.83077490
54Chemical carcinogenesis_Homo sapiens_hsa052040.81250669
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.81064350
56Retinol metabolism_Homo sapiens_hsa008300.80763313
57GABAergic synapse_Homo sapiens_hsa047270.79892241
58Pyrimidine metabolism_Homo sapiens_hsa002400.76165946
59Basal cell carcinoma_Homo sapiens_hsa052170.76070421
60Hedgehog signaling pathway_Homo sapiens_hsa043400.72987974
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72874958
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72572620
63Insulin secretion_Homo sapiens_hsa049110.68829299
64Arachidonic acid metabolism_Homo sapiens_hsa005900.67710827
65Glutamatergic synapse_Homo sapiens_hsa047240.66649629
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66104455
67Base excision repair_Homo sapiens_hsa034100.64355256
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64226768
69Regulation of autophagy_Homo sapiens_hsa041400.63160152
70Long-term depression_Homo sapiens_hsa047300.62960267
71RNA transport_Homo sapiens_hsa030130.59930031
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.59770092
73Ovarian steroidogenesis_Homo sapiens_hsa049130.57702022
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56853375
75Cocaine addiction_Homo sapiens_hsa050300.55334380
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54997054
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51207602
78Vitamin digestion and absorption_Homo sapiens_hsa049770.48854885
79beta-Alanine metabolism_Homo sapiens_hsa004100.48629444
80Metabolic pathways_Homo sapiens_hsa011000.47093646
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45976938
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45811541
83Fat digestion and absorption_Homo sapiens_hsa049750.44401191
84Histidine metabolism_Homo sapiens_hsa003400.43002615
85Glycerolipid metabolism_Homo sapiens_hsa005610.42584619
86Calcium signaling pathway_Homo sapiens_hsa040200.42273954
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42069052
88Salivary secretion_Homo sapiens_hsa049700.42062798
89Primary immunodeficiency_Homo sapiens_hsa053400.40253740
90Circadian rhythm_Homo sapiens_hsa047100.39318712
91Cell cycle_Homo sapiens_hsa041100.36463318
92Dopaminergic synapse_Homo sapiens_hsa047280.34338573
93Collecting duct acid secretion_Homo sapiens_hsa049660.32231691
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31653448
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30842946
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.30711471
97Asthma_Homo sapiens_hsa053100.30091036
98cAMP signaling pathway_Homo sapiens_hsa040240.24175130
99Amphetamine addiction_Homo sapiens_hsa050310.23849402
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23487069

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