ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of mammary gland epithelial cell proliferation (GO:0033599)	4.91177900
2	proline biosynthetic process (GO:0006561)	4.59259690
3	negative regulation of cell size (GO:0045792)	4.46451273
4	planar cell polarity pathway involved in neural tube closure (GO:0090179)	4.00880604
5	Golgi transport vesicle coating (GO:0048200)	3.92674333
6	COPI coating of Golgi vesicle (GO:0048205)	3.92674333
7	desmosome organization (GO:0002934)	3.89379320
8	protein retention in ER lumen (GO:0006621)	3.81190951
9	adherens junction assembly (GO:0034333)	3.77053977
10	negative regulation of erythrocyte differentiation (GO:0045647)	3.73153860
11	apoptotic process involved in morphogenesis (GO:0060561)	3.64765657
12	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.56085614
13	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.55456819
14	cell-substrate adherens junction assembly (GO:0007045)	3.53534856
15	focal adhesion assembly (GO:0048041)	3.53534856
16	regulation of early endosome to late endosome transport (GO:2000641)	3.52565579
17	proline metabolic process (GO:0006560)	3.49071657
18	NADH metabolic process (GO:0006734)	3.49044872
19	maternal placenta development (GO:0001893)	3.44671138
20	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.37791301
21	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.36732917
22	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	3.28889156
23	mitotic chromosome condensation (GO:0007076)	3.24807668
24	DNA unwinding involved in DNA replication (GO:0006268)	3.22443013
25	regulation of glucose import in response to insulin stimulus (GO:2001273)	3.18104575
26	regulation of translational fidelity (GO:0006450)	3.16106458
27	protein localization to endosome (GO:0036010)	3.13434527
28	regulation of NFAT protein import into nucleus (GO:0051532)	3.13304745
29	epithelial cell-cell adhesion (GO:0090136)	3.09230396
30	negative regulation of catenin import into nucleus (GO:0035414)	3.01389002
31	peptidyl-arginine omega-N-methylation (GO:0035247)	3.01130861
32	activation of Rac GTPase activity (GO:0032863)	2.99984560
33	lymph vessel development (GO:0001945)	2.98985724
34	3-UTR-mediated mRNA stabilization (GO:0070935)	2.95193632
35	RNA stabilization (GO:0043489)	2.93600426
36	mRNA stabilization (GO:0048255)	2.93600426
37	intracellular estrogen receptor signaling pathway (GO:0030520)	2.93093380
38	heterochromatin organization (GO:0070828)	2.89261945
39	ribosomal small subunit biogenesis (GO:0042274)	2.88891996
40	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.88606332
41	homocysteine metabolic process (GO:0050667)	2.88586225
42	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	2.86745458
43	cellular protein complex localization (GO:0034629)	2.86490071
44	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.86368602
45	cell-cell junction maintenance (GO:0045217)	2.81822191
46	creatine metabolic process (GO:0006600)	2.81331426
47	mammary gland epithelial cell differentiation (GO:0060644)	2.79223559
48	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.73095131
49	protein complex localization (GO:0031503)	2.72925508
50	regulation of chromatin binding (GO:0035561)	2.72553217
51	basement membrane organization (GO:0071711)	2.69874793
52	cell-substrate junction assembly (GO:0007044)	2.69614610
53	cellular response to epidermal growth factor stimulus (GO:0071364)	2.66608455
54	convergent extension (GO:0060026)	2.66552179
55	urea cycle (GO:0000050)	2.66550094
56	positive regulation of nuclease activity (GO:0032075)	2.65609937
57	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.65229172
58	nucleosome disassembly (GO:0006337)	2.64617679
59	protein-DNA complex disassembly (GO:0032986)	2.64617679
60	gluconeogenesis (GO:0006094)	2.64572825
61	semaphorin-plexin signaling pathway (GO:0071526)	2.64161151
62	embryonic skeletal joint morphogenesis (GO:0060272)	2.62081133
63	negative regulation of fatty acid transport (GO:2000192)	2.61578441
64	response to parathyroid hormone (GO:0071107)	2.58848002
65	4-hydroxyproline metabolic process (GO:0019471)	2.56926109
66	branching involved in mammary gland duct morphogenesis (GO:0060444)	2.56822034
67	endothelial cell chemotaxis (GO:0035767)	2.56633410
68	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.55063045
69	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)	2.53999479
70	cochlea morphogenesis (GO:0090103)	2.53088393
71	pentose-phosphate shunt (GO:0006098)	2.52704404
72	glutamine family amino acid biosynthetic process (GO:0009084)	2.52510050
73	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.52379569
74	regulation of RNA export from nucleus (GO:0046831)	2.50135663
75	peptidyl-lysine dimethylation (GO:0018027)	2.47863147
76	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.47364846
77	monosaccharide biosynthetic process (GO:0046364)	2.46957537
78	regulation of nucleobase-containing compound transport (GO:0032239)	2.45416058
79	glucose 6-phosphate metabolic process (GO:0051156)	2.44232841
80	hexose biosynthetic process (GO:0019319)	2.44141236
81	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.43983298
82	embryonic eye morphogenesis (GO:0048048)	2.43194716
83	negative regulation of striated muscle cell differentiation (GO:0051154)	2.42315350
84	apoptotic process involved in development (GO:1902742)	2.42156700
85	glucose catabolic process (GO:0006007)	2.41898400
86	chromosome condensation (GO:0030261)	2.41105008
87	regulation of fatty acid beta-oxidation (GO:0031998)	2.41094585
88	tricarboxylic acid metabolic process (GO:0072350)	2.40918626
89	folic acid-containing compound biosynthetic process (GO:0009396)	2.40642677
90	outflow tract septum morphogenesis (GO:0003148)	2.39301754
91	atrioventricular valve morphogenesis (GO:0003181)	2.37745969
92	peptidyl-arginine N-methylation (GO:0035246)	2.36627623
93	peptidyl-arginine methylation (GO:0018216)	2.36627623
94	protein localization to microtubule (GO:0035372)	2.36550847
95	activation of MAPKKK activity (GO:0000185)	2.35917990
96	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.35880782
97	positive regulation of myotube differentiation (GO:0010831)	2.35565492
98	urea metabolic process (GO:0019627)	2.34935687
99	regulation of nuclease activity (GO:0032069)	2.34362682
100	mannose metabolic process (GO:0006013)	2.34088431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	LXR_22292898_ChIP-Seq_THP-1_Human	2.78115455
2	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.73858506
3	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.72628754
4	VDR_21846776_ChIP-Seq_THP-1_Human	2.62553490
5	MYC_22102868_ChIP-Seq_BL_Human	2.60331364
6	ZNF263_19887448_ChIP-Seq_K562_Human	2.51568767
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.40250065
8	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.38820380
9	RACK7_27058665_Chip-Seq_MCF-7_Human	2.38200369
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.36047259
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.33053030
12	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.28791001
13	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.23945197
14	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.20978225
15	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.16175025
16	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.11343193
17	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.09230836
18	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.02712018
19	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.90223369
20	KDM2B_26808549_Chip-Seq_DND41_Human	1.85142719
21	TCF7_22412390_ChIP-Seq_EML_Mouse	1.84447352
22	KDM2B_26808549_Chip-Seq_K562_Human	1.79882512
23	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.78766718
24	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.74633697
25	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.72793879
26	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.71639126
27	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.69546207
28	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.69247914
29	* P68_20966046_ChIP-Seq_HELA_Human	1.67090470
30	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.65063661
31	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.65059391
32	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.54729939
33	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.54657757
34	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.54608121
35	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.53953735
36	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.53196702
37	CLOCK_20551151_ChIP-Seq_293T_Human	1.51185030
38	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.50747189
39	XRN2_22483619_ChIP-Seq_HELA_Human	1.47979639
40	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.47800954
41	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.47408748
42	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.47209070
43	* CREB1_26743006_Chip-Seq_LNCaP_Human	1.47027518
44	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.46877277
45	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.43826124
46	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.43407764
47	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.41445244
48	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.41409009
49	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.40137594
50	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.40029491
51	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.39749349
52	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.37775586
53	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.37558068
54	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.37502225
55	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.36690301
56	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.36456228
57	SMC4_20622854_ChIP-Seq_HELA_Human	1.36178420
58	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.34860731
59	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.33552221
60	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.30861000
61	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.30514844
62	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30195152
63	ATF3_27146783_Chip-Seq_COLON_Human	1.28792931
64	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.27801700
65	* NCOR1_26117541_ChIP-Seq_K562_Human	1.25383565
66	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.24882884
67	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.21196842
68	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.21154637
69	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.18912120
70	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.18731859
71	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.18528632
72	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.16703638
73	CTCF_27219007_Chip-Seq_Bcells_Human	1.16659693
74	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.16221192
75	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.15991302
76	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.15765548
77	TP53_22127205_ChIP-Seq_IMR90_Human	1.14791736
78	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.13417898
79	* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.11414909
80	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.09951984
81	* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.05361248
82	* ELF1_20517297_ChIP-Seq_JURKAT_Human	1.03946943
83	VDR_24763502_ChIP-Seq_THP-1_Human	1.03650754
84	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.02522310
85	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.02122627
86	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.00879283
87	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.00830338
88	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.00233783
89	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.99978550
90	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.99751202
91	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.99747788
92	MAF_26560356_Chip-Seq_TH2_Human	0.99507774
93	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.99337503
94	BCOR_27268052_Chip-Seq_Bcells_Human	0.97867354
95	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.96438573
96	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.96015475
97	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.95597111
98	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.94933424
99	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.94591177
100	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.94110044

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003705_abnormal_hypodermis_morpholog	5.35855882
2	MP0005451_abnormal_body_composition	3.16746273
3	MP0004185_abnormal_adipocyte_glucose	3.03329297
4	MP0005076_abnormal_cell_differentiation	2.91625453
5	MP0002249_abnormal_larynx_morphology	2.68735527
6	MP0000678_abnormal_parathyroid_gland	2.55706553
7	MP0010234_abnormal_vibrissa_follicle	2.53683193
8	MP0004233_abnormal_muscle_weight	2.46770068
9	MP0000751_myopathy	2.43664058
10	MP0004858_abnormal_nervous_system	2.41831546
11	MP0005058_abnormal_lysosome_morphology	2.37153010
12	MP0002877_abnormal_melanocyte_morpholog	2.33081116
13	MP0005670_abnormal_white_adipose	2.15303164
14	MP0000003_abnormal_adipose_tissue	2.09591424
15	MP0005409_darkened_coat_color	2.08209709
16	MP0001849_ear_inflammation	2.07527409
17	MP0000537_abnormal_urethra_morphology	2.06564067
18	MP0000747_muscle_weakness	1.99251979
19	MP0005623_abnormal_meninges_morphology	1.97752469
20	MP0005666_abnormal_adipose_tissue	1.95134559
21	MP0000733_abnormal_muscle_development	1.84660861
22	MP0005375_adipose_tissue_phenotype	1.76944863
23	MP0000566_synostosis	1.73293049
24	MP0000759_abnormal_skeletal_muscle	1.69868096
25	MP0001346_abnormal_lacrimal_gland	1.60984289
26	MP0004087_abnormal_muscle_fiber	1.60266446
27	MP0010030_abnormal_orbit_morphology	1.58531812
28	MP0001661_extended_life_span	1.55375199
29	MP0009840_abnormal_foam_cell	1.50786968
30	MP0003453_abnormal_keratinocyte_physiol	1.48835984
31	MP0009672_abnormal_birth_weight	1.47696791
32	MP0002796_impaired_skin_barrier	1.44500322
33	MP0003566_abnormal_cell_adhesion	1.43933907
34	MP0003123_paternal_imprinting	1.42342586
35	MP0003111_abnormal_nucleus_morphology	1.41916851
36	MP0000534_abnormal_ureter_morphology	1.40631274
37	MP0010630_abnormal_cardiac_muscle	1.40039323
38	MP0005360_urolithiasis	1.38351375
39	MP0000013_abnormal_adipose_tissue	1.37563295
40	MP0001730_embryonic_growth_arrest	1.36760720
41	MP0003942_abnormal_urinary_system	1.35192957
42	MP0002089_abnormal_postnatal_growth/wei	1.34013898
43	MP0005501_abnormal_skin_physiology	1.32992875
44	MP0000750_abnormal_muscle_regeneration	1.31904074
45	MP0004264_abnormal_extraembryonic_tissu	1.31713915
46	MP0002269_muscular_atrophy	1.26686811
47	MP0005330_cardiomyopathy	1.26613192
48	MP0009053_abnormal_anal_canal	1.25288785
49	MP0003693_abnormal_embryo_hatching	1.20866286
50	MP0000749_muscle_degeneration	1.20518282
51	MP0000681_abnormal_thyroid_gland	1.16666384
52	MP0005257_abnormal_intraocular_pressure	1.14678215
53	MP0001348_abnormal_lacrimal_gland	1.10568798
54	MP0008438_abnormal_cutaneous_collagen	1.10219210
55	MP0009278_abnormal_bone_marrow	1.09626706
56	MP0002098_abnormal_vibrissa_morphology	1.08763828
57	MP0008260_abnormal_autophagy	1.07720865
58	MP0004130_abnormal_muscle_cell	1.07221622
59	MP0004272_abnormal_basement_membrane	1.03428752
60	MP0006138_congestive_heart_failure	1.02330602
61	MP0000762_abnormal_tongue_morphology	1.00391927
62	MP0000579_abnormal_nail_morphology	0.99487685
63	MP0000467_abnormal_esophagus_morphology	0.94493048
64	MP0002697_abnormal_eye_size	0.93033695
65	MP0002060_abnormal_skin_morphology	0.91662519
66	MP0000350_abnormal_cell_proliferation	0.90552928
67	MP0002080_prenatal_lethality	0.90163221
68	MP0003115_abnormal_respiratory_system	0.90142394
69	MP0010352_gastrointestinal_tract_polyps	0.87601869
70	MP0003183_abnormal_peptide_metabolism	0.86470781
71	MP0003984_embryonic_growth_retardation	0.85088562
72	MP0001672_abnormal_embryogenesis/_devel	0.84517133
73	MP0005380_embryogenesis_phenotype	0.84517133
74	MP0004036_abnormal_muscle_relaxation	0.84034713
75	MP0000858_altered_metastatic_potential	0.83211852
76	MP0003077_abnormal_cell_cycle	0.83157877
77	MP0002108_abnormal_muscle_morphology	0.82799343
78	MP0002106_abnormal_muscle_physiology	0.81935499
79	MP0002896_abnormal_bone_mineralization	0.81930398
80	MP0009379_abnormal_foot_pigmentation	0.81589043
81	MP0004782_abnormal_surfactant_physiolog	0.80650535
82	MP0002085_abnormal_embryonic_tissue	0.78300734
83	MP0003329_amyloid_beta_deposits	0.78234945
84	MP0002088_abnormal_embryonic_growth/wei	0.78027420
85	MP0000462_abnormal_digestive_system	0.77875960
86	MP0002086_abnormal_extraembryonic_tissu	0.77658469
87	MP0003315_abnormal_perineum_morphology	0.76128281
88	MP0002114_abnormal_axial_skeleton	0.75988403
89	MP0003191_abnormal_cellular_cholesterol	0.75692481
90	MP0005369_muscle_phenotype	0.74507017
91	MP0009931_abnormal_skin_appearance	0.74216552
92	MP0002092_abnormal_eye_morphology	0.73580334
93	MP0003091_abnormal_cell_migration	0.73393349
94	MP0002396_abnormal_hematopoietic_system	0.72918880
95	MP0008932_abnormal_embryonic_tissue	0.72867475
96	MP0004957_abnormal_blastocyst_morpholog	0.72094286
97	MP0009384_cardiac_valve_regurgitation	0.71067335
98	MP0002932_abnormal_joint_morphology	0.70933719
99	MP0003172_abnormal_lysosome_physiology	0.70831552
100	MP0009250_abnormal_appendicular_skeleto	0.70002639

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myopathic facies (HP:0002058)	3.84370662
2	Hyperacusis (HP:0010780)	3.68355361
3	Exercise-induced myalgia (HP:0003738)	3.10262369
4	Distal lower limb amyotrophy (HP:0008944)	3.01594216
5	Ulnar bowing (HP:0003031)	2.97581545
6	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.95551101
7	Increased connective tissue (HP:0009025)	2.85097073
8	Distal lower limb muscle weakness (HP:0009053)	2.80396273
9	Flat acetabular roof (HP:0003180)	2.70086073
10	Achilles tendon contracture (HP:0001771)	2.67336661
11	Type 1 muscle fiber predominance (HP:0003803)	2.66110224
12	Insomnia (HP:0100785)	2.52222552
13	Muscle fiber inclusion bodies (HP:0100299)	2.48182184
14	Protrusio acetabuli (HP:0003179)	2.46776486
15	Mildly elevated creatine phosphokinase (HP:0008180)	2.46124950
16	Abnormality of the Achilles tendon (HP:0005109)	2.44791516
17	Abnormality of the phalanges of the hallux (HP:0010057)	2.43756728
18	Disproportionate tall stature (HP:0001519)	2.39524527
19	Asymmetry of the thorax (HP:0001555)	2.37759951
20	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.36997975
21	Progressive muscle weakness (HP:0003323)	2.36864530
22	Abnormality of the fetal cardiovascular system (HP:0010948)	2.34836174
23	Abnormal umbilical cord blood vessels (HP:0011403)	2.34836174
24	Single umbilical artery (HP:0001195)	2.34836174
25	Increased variability in muscle fiber diameter (HP:0003557)	2.34666622
26	Abnormality of the umbilical cord (HP:0010881)	2.33347304
27	Abnormality of skeletal muscle fiber size (HP:0012084)	2.30688078
28	Cerebral aneurysm (HP:0004944)	2.29712477
29	Vertebral compression fractures (HP:0002953)	2.29638556
30	Nemaline bodies (HP:0003798)	2.29151154
31	Septate vagina (HP:0001153)	2.26697880
32	Stridor (HP:0010307)	2.25468884
33	Biconcave vertebral bodies (HP:0004586)	2.20453487
34	Thin ribs (HP:0000883)	2.19498982
35	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.18076922
36	Obstructive sleep apnea (HP:0002870)	2.17998794
37	Thin bony cortex (HP:0002753)	2.17388202
38	Deep venous thrombosis (HP:0002625)	2.16133889
39	Back pain (HP:0003418)	2.13559979
40	Round ear (HP:0100830)	2.13269948
41	Lower limb amyotrophy (HP:0007210)	2.13045887
42	Abnormality of the thoracic spine (HP:0100711)	2.12169457
43	Bulbar palsy (HP:0001283)	2.12148002
44	Hyperparathyroidism (HP:0000843)	2.07079534
45	Broad face (HP:0000283)	2.06504440
46	Broad distal phalanx of finger (HP:0009836)	2.05506917
47	Abnormality of the calcaneus (HP:0008364)	2.03734916
48	Dysmetric saccades (HP:0000641)	2.03480129
49	Ragged-red muscle fibers (HP:0003200)	1.98209364
50	Calcaneovalgus deformity (HP:0001848)	1.97861947
51	Distal upper limb amyotrophy (HP:0007149)	1.97658468
52	Upper limb amyotrophy (HP:0009129)	1.97658468
53	Diaphragmatic weakness (HP:0009113)	1.96510793
54	Bowel incontinence (HP:0002607)	1.96055052
55	Long palpebral fissure (HP:0000637)	1.95499695
56	Abnormality of the distal phalanges of the toes (HP:0010182)	1.95465044
57	Spinal rigidity (HP:0003306)	1.94012033
58	Esophageal varix (HP:0002040)	1.93639497
59	Germ cell neoplasia (HP:0100728)	1.91677789
60	Hypercortisolism (HP:0001578)	1.89210027
61	Abnormal large intestine physiology (HP:0012700)	1.87552106
62	Premature rupture of membranes (HP:0001788)	1.87438595
63	Truncus arteriosus (HP:0001660)	1.86023625
64	Difficulty climbing stairs (HP:0003551)	1.83914152
65	Turricephaly (HP:0000262)	1.83800538
66	Abnormality of the tricuspid valve (HP:0001702)	1.80707487
67	Reticulocytosis (HP:0001923)	1.78489369
68	Ulnar deviation of the wrist (HP:0003049)	1.78110372
69	Lymphangioma (HP:0100764)	1.78036568
70	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.77852002
71	Abnormality of the left ventricular outflow tract (HP:0011103)	1.76570825
72	Subaortic stenosis (HP:0001682)	1.76570825
73	Visceral angiomatosis (HP:0100761)	1.76391458
74	Patellar dislocation (HP:0002999)	1.76184408
75	Trismus (HP:0000211)	1.75752409
76	Hyperthyroidism (HP:0000836)	1.75147553
77	Hemorrhage of the eye (HP:0011885)	1.74362374
78	Hyporeflexia of lower limbs (HP:0002600)	1.73623240
79	Progressive external ophthalmoplegia (HP:0000590)	1.73455628
80	Advanced eruption of teeth (HP:0006288)	1.72857195
81	Asymmetric septal hypertrophy (HP:0001670)	1.72271753
82	Abnormal ventriculo-arterial connection (HP:0011563)	1.71773332
83	Transposition of the great arteries (HP:0001669)	1.71773332
84	Abnormal connection of the cardiac segments (HP:0011545)	1.71773332
85	Abnormal gallbladder physiology (HP:0012438)	1.71211869
86	Cholecystitis (HP:0001082)	1.71211869
87	Thoracic kyphosis (HP:0002942)	1.70296716
88	Mitral regurgitation (HP:0001653)	1.69979196
89	Foot dorsiflexor weakness (HP:0009027)	1.69921667
90	J-shaped sella turcica (HP:0002680)	1.68154749
91	Abnormality of the aortic arch (HP:0012303)	1.67698735
92	Hemangiomatosis (HP:0007461)	1.67485165
93	Shallow orbits (HP:0000586)	1.66354446
94	Rectal prolapse (HP:0002035)	1.65333562
95	Ventricular tachycardia (HP:0004756)	1.65196966
96	Hypercalcemia (HP:0003072)	1.64404847
97	Fragile skin (HP:0001030)	1.64003623
98	Easy fatigability (HP:0003388)	1.62904911
99	Overriding aorta (HP:0002623)	1.62411971
100	Abnormality of carpal bone ossification (HP:0006257)	1.61738322

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	5.77315598
2	EEF2K	4.20689301
3	SMG1	3.50837019
4	SIK1	3.02181245
5	ICK	3.00495880
6	PRPF4B	2.65601214
7	IRAK3	2.62794224
8	CDK12	2.58366495
9	NME2	2.46225654
10	TTN	2.33718439
11	PKN2	2.19083229
12	MAP3K10	2.13214912
13	RIPK1	2.01941854
14	ERN1	1.95489979
15	EPHA2	1.92906919
16	MAP2K3	1.82323232
17	RPS6KB2	1.65027396
18	FGFR4	1.46081356
19	PRKD3	1.40200833
20	* MTOR	1.22927565
21	PDGFRA	1.21618191
22	TAOK2	1.14404025
23	MST1R	1.10836068
24	KSR2	1.07181719
25	MAP3K3	1.07096770
26	PTK6	1.05659427
27	LATS2	1.04598613
28	ARAF	1.03791118
29	PAK4	1.02649650
30	TESK1	0.97722340
31	MAP2K2	0.97071018
32	MAP3K11	0.96065788
33	OBSCN	0.93583740
34	BRAF	0.93117395
35	SCYL2	0.91608320
36	PDPK1	0.90834938
37	CDK7	0.88719364
38	PHKG2	0.87811407
39	PHKG1	0.87811407
40	RPS6KA2	0.87517038
41	MARK2	0.80336334
42	RPS6KC1	0.80092037
43	RPS6KL1	0.80092037
44	MAPKAPK3	0.79037217
45	PTK2	0.77921273
46	NTRK1	0.75530486
47	DMPK	0.74011169
48	IRAK2	0.73904560
49	MAP3K1	0.73203909
50	ILK	0.72515707
51	AKT2	0.72501718
52	MAPK11	0.71972729
53	MAP3K8	0.71680131
54	LRRK2	0.71485443
55	CDK4	0.71290586
56	MAP3K13	0.68547039
57	CDC42BPA	0.67057109
58	SIK2	0.66891058
59	CDK9	0.65209400
60	EPHB2	0.65069755
61	LMTK2	0.63943317
62	DDR2	0.63913947
63	TYRO3	0.63277365
64	RPS6KA6	0.58549295
65	CAMK1D	0.58032037
66	MAP3K9	0.57878505
67	HIPK2	0.57730540
68	MAPK12	0.56059787
69	AURKA	0.55503437
70	PRKD2	0.53705294
71	BMX	0.52998519
72	DYRK1B	0.51111828
73	RPS6KA1	0.49913518
74	MUSK	0.49702480
75	SGK3	0.49223051
76	TAOK1	0.46172255
77	KDR	0.45910834
78	CDK6	0.44763836
79	RET	0.42692885
80	BRSK1	0.41446712
81	BRD4	0.41160296
82	PIM2	0.39754347
83	CAMK1G	0.39441008
84	CHEK2	0.38522945
85	TBK1	0.37321828
86	PRKG2	0.37106993
87	CHEK1	0.36793531
88	MAP3K7	0.36438283
89	MAP2K1	0.36330985
90	CDK2	0.36239525
91	PRKCI	0.35872018
92	PAK2	0.35237877
93	CDK8	0.34951343
94	MET	0.34799859
95	PDK1	0.34296791
96	MAP3K6	0.33850693
97	TESK2	0.32358410
98	CAMK2G	0.32280848
99	PRKAA1	0.32221928
100	RPS6KB1	0.31955599

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.76202792
2	Other glycan degradation_Homo sapiens_hsa00511	2.58377557
3	Sulfur relay system_Homo sapiens_hsa04122	2.46165804
4	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.33172351
5	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.15960754
6	Pentose phosphate pathway_Homo sapiens_hsa00030	2.02103869
7	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.00740030
8	Bladder cancer_Homo sapiens_hsa05219	2.00318101
9	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.97397442
10	Arginine biosynthesis_Homo sapiens_hsa00220	1.97253282
11	Galactose metabolism_Homo sapiens_hsa00052	1.88349456
12	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.87873236
13	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.84536610
14	Notch signaling pathway_Homo sapiens_hsa04330	1.81728194
15	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.71723189
16	Thyroid cancer_Homo sapiens_hsa05216	1.71302207
17	Non-small cell lung cancer_Homo sapiens_hsa05223	1.70809891
18	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.70164725
19	Prion diseases_Homo sapiens_hsa05020	1.65252754
20	Acute myeloid leukemia_Homo sapiens_hsa05221	1.60752349
21	Insulin signaling pathway_Homo sapiens_hsa04910	1.59442967
22	VEGF signaling pathway_Homo sapiens_hsa04370	1.55758059
23	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.52813202
24	AMPK signaling pathway_Homo sapiens_hsa04152	1.46814782
25	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.43487383
26	Endometrial cancer_Homo sapiens_hsa05213	1.40965928
27	Carbon metabolism_Homo sapiens_hsa01200	1.39216555
28	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.34541701
29	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.34402051
30	Pancreatic cancer_Homo sapiens_hsa05212	1.30507189
31	mTOR signaling pathway_Homo sapiens_hsa04150	1.27703579
32	Glioma_Homo sapiens_hsa05214	1.25043683
33	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.21801249
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.19873572
35	Arginine and proline metabolism_Homo sapiens_hsa00330	1.15263991
36	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.14771173
37	ErbB signaling pathway_Homo sapiens_hsa04012	1.14637295
38	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.09679458
39	Renal cell carcinoma_Homo sapiens_hsa05211	1.08560695
40	Lysine degradation_Homo sapiens_hsa00310	1.01492252
41	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.99223235
42	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.95907141
43	GnRH signaling pathway_Homo sapiens_hsa04912	0.95448857
44	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.94657543
45	Insulin resistance_Homo sapiens_hsa04931	0.94624624
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.93598640
47	DNA replication_Homo sapiens_hsa03030	0.90447223
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89789010
49	Glucagon signaling pathway_Homo sapiens_hsa04922	0.86436344
50	MicroRNAs in cancer_Homo sapiens_hsa05206	0.83865134
51	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.82534557
52	Focal adhesion_Homo sapiens_hsa04510	0.82121662
53	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.81850486
54	mRNA surveillance pathway_Homo sapiens_hsa03015	0.81238992
55	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.80925333
56	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.80781457
57	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.79422198
58	Estrogen signaling pathway_Homo sapiens_hsa04915	0.79294295
59	Vibrio cholerae infection_Homo sapiens_hsa05110	0.79162314
60	Prostate cancer_Homo sapiens_hsa05215	0.76319858
61	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.76078335
62	Choline metabolism in cancer_Homo sapiens_hsa05231	0.75767737
63	Small cell lung cancer_Homo sapiens_hsa05222	0.75462817
64	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.72716136
65	Proteoglycans in cancer_Homo sapiens_hsa05205	0.72638704
66	Adherens junction_Homo sapiens_hsa04520	0.72504841
67	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.70752153
68	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.68519528
69	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.66797074
70	One carbon pool by folate_Homo sapiens_hsa00670	0.66400832
71	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.65319377
72	Colorectal cancer_Homo sapiens_hsa05210	0.64395586
73	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.62850446
74	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.62567457
75	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.60946448
76	Base excision repair_Homo sapiens_hsa03410	0.59806463
77	Prolactin signaling pathway_Homo sapiens_hsa04917	0.59632958
78	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56636054
79	Tight junction_Homo sapiens_hsa04530	0.55825224
80	Amoebiasis_Homo sapiens_hsa05146	0.54504944
81	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.53872293
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.52941228
83	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.52898605
84	Apoptosis_Homo sapiens_hsa04210	0.52883929
85	Bile secretion_Homo sapiens_hsa04976	0.52277667
86	Spliceosome_Homo sapiens_hsa03040	0.51746237
87	Melanogenesis_Homo sapiens_hsa04916	0.51370659
88	HTLV-I infection_Homo sapiens_hsa05166	0.51119626
89	Viral carcinogenesis_Homo sapiens_hsa05203	0.49111003
90	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.48436743
91	Long-term potentiation_Homo sapiens_hsa04720	0.47271984
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.46290771
93	Hepatitis C_Homo sapiens_hsa05160	0.45164833
94	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43442703
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.43412917
96	PPAR signaling pathway_Homo sapiens_hsa03320	0.41333815
97	Cell cycle_Homo sapiens_hsa04110	0.40783120
98	Endocytosis_Homo sapiens_hsa04144	0.40532453
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.39575957
100	Lysosome_Homo sapiens_hsa04142	0.36575143

ZNF768

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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