ZNF77

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)9.50573941
2positive regulation of uterine smooth muscle contraction (GO:0070474)8.36956545
3cellular zinc ion homeostasis (GO:0006882)7.34562322
4regulation of uterine smooth muscle contraction (GO:0070472)6.57275268
5actin filament depolymerization (GO:0030042)6.53710543
6organelle membrane fusion (GO:0090174)6.33158808
7protein K11-linked deubiquitination (GO:0035871)6.19064746
8zinc ion homeostasis (GO:0055069)6.08606498
9monoubiquitinated protein deubiquitination (GO:0035520)5.66665468
10fucosylation (GO:0036065)5.64667067
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.63931724
12positive regulation of gamma-delta T cell activation (GO:0046645)5.08268846
13cell migration involved in gastrulation (GO:0042074)5.07254122
14regulation of developmental pigmentation (GO:0048070)4.86450694
15basement membrane organization (GO:0071711)4.57434935
16regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.56806808
17protein carboxylation (GO:0018214)4.51268353
18peptidyl-glutamic acid carboxylation (GO:0017187)4.51268353
19positive regulation of gluconeogenesis (GO:0045722)4.50284886
20lens fiber cell development (GO:0070307)4.47245501
21regulation of gamma-delta T cell differentiation (GO:0045586)4.45360666
22nuclear envelope reassembly (GO:0031468)4.43406951
23mitotic nuclear envelope reassembly (GO:0007084)4.43406951
24endosome to melanosome transport (GO:0035646)4.29366055
25endosome to pigment granule transport (GO:0043485)4.29366055
26melanosome localization (GO:0032400)4.25136120
27fat-soluble vitamin biosynthetic process (GO:0042362)4.14301300
28cell proliferation in forebrain (GO:0021846)4.07594319
29RNA destabilization (GO:0050779)4.06931803
30pigment granule localization (GO:0051875)4.01215044
31sex differentiation (GO:0007548)3.94078609
32protein K48-linked deubiquitination (GO:0071108)3.85999762
33regulation of T cell receptor signaling pathway (GO:0050856)3.83365844
34positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.79641843
35activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.72110650
36lysosome localization (GO:0032418)3.69141206
37negative regulation of circadian rhythm (GO:0042754)3.60807816
38protein neddylation (GO:0045116)3.59228759
39regulation of B cell apoptotic process (GO:0002902)3.59182325
40regulation of gamma-delta T cell activation (GO:0046643)3.48126760
41positive regulation of smooth muscle contraction (GO:0045987)3.45657876
42cellular response to nitric oxide (GO:0071732)3.40631711
43regulation of penile erection (GO:0060405)3.34362620
44cullin deneddylation (GO:0010388)3.28205213
45fucose catabolic process (GO:0019317)3.28171352
46L-fucose metabolic process (GO:0042354)3.28171352
47L-fucose catabolic process (GO:0042355)3.28171352
48terpenoid biosynthetic process (GO:0016114)3.27193427
49negative regulation of macrophage differentiation (GO:0045650)3.26637894
50negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.25914768
51DNA replication checkpoint (GO:0000076)3.21220820
52N-acetylglucosamine metabolic process (GO:0006044)3.18254778
53replication fork processing (GO:0031297)3.17871373
54vitamin biosynthetic process (GO:0009110)3.09140772
55succinate metabolic process (GO:0006105)3.09031508
56cerebellar granule cell differentiation (GO:0021707)3.07753579
57regulation of double-strand break repair via homologous recombination (GO:0010569)3.07404366
58negative regulation of DNA repair (GO:0045738)3.06758945
59negative regulation of B cell apoptotic process (GO:0002903)2.99062547
60transcription from RNA polymerase III promoter (GO:0006383)2.96779356
61somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96662212
62somatic hypermutation of immunoglobulin genes (GO:0016446)2.96662212
63antigen processing and presentation via MHC class Ib (GO:0002475)2.96222368
64purine nucleobase biosynthetic process (GO:0009113)2.93857400
65protein deneddylation (GO:0000338)2.93699573
66nucleobase biosynthetic process (GO:0046112)2.91053947
67protein localization to vacuole (GO:0072665)2.90739091
68protein localization to lysosome (GO:0061462)2.90739091
69negative regulation of thymocyte apoptotic process (GO:0070244)2.88097024
70regulation of cell maturation (GO:1903429)2.84897857
71positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)2.84352950
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.81013119
73respiratory chain complex IV assembly (GO:0008535)2.77094133
74platelet formation (GO:0030220)2.76417152
75protein targeting to lysosome (GO:0006622)2.74726710
76establishment of protein localization to vacuole (GO:0072666)2.74726710
77protein targeting to vacuole (GO:0006623)2.74726710
78purine nucleotide salvage (GO:0032261)2.73165498
79protein K6-linked ubiquitination (GO:0085020)2.72798180
80vitamin D metabolic process (GO:0042359)2.71347002
81histone deubiquitination (GO:0016578)2.68916727
82purine deoxyribonucleotide catabolic process (GO:0009155)2.68640953
83ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.68448898
84protein depolymerization (GO:0051261)2.67499655
85protein K63-linked deubiquitination (GO:0070536)2.67336598
86regulation of meiosis I (GO:0060631)2.67186267
87negative regulation of T cell differentiation in thymus (GO:0033085)2.62316293
88anterograde synaptic vesicle transport (GO:0048490)2.62249220
89asymmetric protein localization (GO:0008105)2.59173697
90purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.58463414
91negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57527197
92histamine secretion (GO:0001821)2.57011069
93melanosome organization (GO:0032438)2.56817862
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56751481
95negative regulation of T cell apoptotic process (GO:0070233)2.55732538
96kidney morphogenesis (GO:0060993)2.53179160
97positive regulation of muscle contraction (GO:0045933)2.48353752
98mitochondrial respiratory chain complex assembly (GO:0033108)2.47474674
99negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.47049548
100cytochrome complex assembly (GO:0017004)2.46556497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.20249991
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91808789
3ZNF274_21170338_ChIP-Seq_K562_Hela3.61188467
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.52813557
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.43018752
6CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.24571632
7CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72268087
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71184394
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68748107
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.68279470
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.68149318
12* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62066166
13ELK1_19687146_ChIP-ChIP_HELA_Human2.61627653
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.58073879
15E2F7_22180533_ChIP-Seq_HELA_Human2.57918424
16VDR_23849224_ChIP-Seq_CD4+_Human2.30008789
17FOXP3_21729870_ChIP-Seq_TREG_Human2.29422051
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21841820
19FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06798295
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04157775
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.02171908
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.00022828
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.89811956
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89769089
25* GABP_19822575_ChIP-Seq_HepG2_Human1.88922007
26* DCP1A_22483619_ChIP-Seq_HELA_Human1.84739058
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83052612
28FUS_26573619_Chip-Seq_HEK293_Human1.78909265
29FOXA1_25329375_ChIP-Seq_VCAP_Human1.77695082
30FOXA1_27270436_Chip-Seq_PROSTATE_Human1.77695082
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76249920
32VDR_22108803_ChIP-Seq_LS180_Human1.73865088
33EWS_26573619_Chip-Seq_HEK293_Human1.73155491
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70994158
35BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.69471030
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66874234
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65403095
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58728271
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58605399
40MYC_18940864_ChIP-ChIP_HL60_Human1.58390906
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57309673
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55840624
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54614091
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47416240
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43828810
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42743337
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42715525
48* KDM5A_27292631_Chip-Seq_BREAST_Human1.38231184
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38225547
50TP53_22573176_ChIP-Seq_HFKS_Human1.35462763
51HTT_18923047_ChIP-ChIP_STHdh_Human1.30729681
52E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29445808
53AR_20517297_ChIP-Seq_VCAP_Human1.29034179
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24598278
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24444738
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24302946
57FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18100453
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15891993
59ER_23166858_ChIP-Seq_MCF-7_Human1.14846742
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11550880
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10938065
62* XRN2_22483619_ChIP-Seq_HELA_Human1.07490208
63TTF2_22483619_ChIP-Seq_HELA_Human1.05684465
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03469469
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03363765
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02499956
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.01989882
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00685607
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.00681762
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.00674994
71P300_19829295_ChIP-Seq_ESCs_Human1.00109895
72YY1_21170310_ChIP-Seq_MESCs_Mouse0.98611414
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96511446
74CBP_21632823_ChIP-Seq_H3396_Human0.93638361
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91983017
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91365399
77* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90434537
78SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90040291
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88817202
80TAF2_19829295_ChIP-Seq_ESCs_Human0.88114956
81LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87236662
82ERG_20517297_ChIP-Seq_VCAP_Human0.86475507
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85847975
84TP53_16413492_ChIP-PET_HCT116_Human0.85459078
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85452332
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85427533
87* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85161002
88MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85148817
89NANOG_20526341_ChIP-Seq_ESCs_Human0.84872576
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84447288
91MYC_18555785_ChIP-Seq_MESCs_Mouse0.84441888
92SOX9_26525672_Chip-Seq_HEART_Mouse0.83988514
93SOX2_19829295_ChIP-Seq_ESCs_Human0.83578925
94NANOG_19829295_ChIP-Seq_ESCs_Human0.83578925
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82980377
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81823189
97SALL4_22934838_ChIP-ChIP_CD34+_Human0.81362879
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81163303
99ELF5_23300383_ChIP-Seq_T47D_Human0.80654685
100CBP_20019798_ChIP-Seq_JUKART_Human0.79769484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005075_abnormal_melanosome_morpholog6.71383111
2MP0005408_hypopigmentation6.67603394
3MP0000569_abnormal_digit_pigmentation4.33040823
4MP0008007_abnormal_cellular_replicative3.77983443
5MP0010234_abnormal_vibrissa_follicle3.46618308
6MP0000566_synostosis3.33685690
7MP0009697_abnormal_copulation3.15189384
8MP0003890_abnormal_embryonic-extraembry2.99569924
9MP0005174_abnormal_tail_pigmentation2.75497230
10MP0000371_diluted_coat_color2.69276114
11MP0003693_abnormal_embryo_hatching2.69256348
12MP0003718_maternal_effect2.62823011
13MP0002653_abnormal_ependyma_morphology2.49820348
14MP0000015_abnormal_ear_pigmentation2.10246320
15MP0003111_abnormal_nucleus_morphology2.08902447
16MP0001293_anophthalmia2.04568702
17MP0001919_abnormal_reproductive_system2.04293205
18MP0002938_white_spotting1.94699628
19MP0008058_abnormal_DNA_repair1.86639190
20MP0001324_abnormal_eye_pigmentation1.69012912
21MP0006292_abnormal_olfactory_placode1.67277995
22MP0008875_abnormal_xenobiotic_pharmacok1.66617564
23MP0008057_abnormal_DNA_replication1.57532347
24MP0008877_abnormal_DNA_methylation1.53772334
25MP0006035_abnormal_mitochondrial_morpho1.53015301
26MP0010094_abnormal_chromosome_stability1.50179611
27MP0002075_abnormal_coat/hair_pigmentati1.46132773
28MP0002095_abnormal_skin_pigmentation1.42977964
29MP0003172_abnormal_lysosome_physiology1.41828075
30MP0008932_abnormal_embryonic_tissue1.40968778
31MP0005389_reproductive_system_phenotype1.37968585
32MP0004957_abnormal_blastocyst_morpholog1.36635344
33MP0003011_delayed_dark_adaptation1.35852689
34MP0003077_abnormal_cell_cycle1.34450366
35MP0003950_abnormal_plasma_membrane1.32250456
36MP0003252_abnormal_bile_duct1.26606364
37MP0001968_abnormal_touch/_nociception1.26214151
38MP0003763_abnormal_thymus_physiology1.22198128
39MP0001929_abnormal_gametogenesis1.19398175
40MP0006036_abnormal_mitochondrial_physio1.17554947
41MP0010678_abnormal_skin_adnexa1.17188148
42MP0001529_abnormal_vocalization1.11448303
43MP0003698_abnormal_male_reproductive1.06451696
44MP0002234_abnormal_pharynx_morphology1.06002659
45MP0001186_pigmentation_phenotype1.05320274
46MP0001944_abnormal_pancreas_morphology1.05252756
47MP0005197_abnormal_uvea_morphology1.03981207
48MP0004147_increased_porphyrin_level1.03489739
49MP0002210_abnormal_sex_determination1.02745664
50MP0002638_abnormal_pupillary_reflex1.00210796
51MP0005391_vision/eye_phenotype0.98859579
52MP0005084_abnormal_gallbladder_morpholo0.98662178
53MP0001119_abnormal_female_reproductive0.98649590
54MP0005253_abnormal_eye_physiology0.97874033
55MP0001764_abnormal_homeostasis0.95791439
56MP0000358_abnormal_cell_content/0.94147135
57MP0002751_abnormal_autonomic_nervous0.91869601
58MP0002736_abnormal_nociception_after0.91600983
59MP0008872_abnormal_physiological_respon0.89339044
60MP0003937_abnormal_limbs/digits/tail_de0.89244440
61MP0001672_abnormal_embryogenesis/_devel0.86960575
62MP0005380_embryogenesis_phenotype0.86960575
63MP0005551_abnormal_eye_electrophysiolog0.86928071
64MP0005410_abnormal_fertilization0.86081613
65MP0009250_abnormal_appendicular_skeleto0.85991407
66MP0002092_abnormal_eye_morphology0.85097422
67MP0001177_atelectasis0.80896640
68MP0000653_abnormal_sex_gland0.79307170
69MP0001145_abnormal_male_reproductive0.78899750
70MP0004782_abnormal_surfactant_physiolog0.78077156
71MP0005360_urolithiasis0.77117411
72MP0001986_abnormal_taste_sensitivity0.76959772
73MP0002254_reproductive_system_inflammat0.75028541
74MP0002138_abnormal_hepatobiliary_system0.74221682
75MP0002161_abnormal_fertility/fecundity0.72799053
76MP0001502_abnormal_circadian_rhythm0.72714121
77MP0005167_abnormal_blood-brain_barrier0.69914131
78MP0001697_abnormal_embryo_size0.69239153
79MP0004885_abnormal_endolymph0.69033039
80MP0005083_abnormal_biliary_tract0.68793830
81MP0006276_abnormal_autonomic_nervous0.67250110
82MP0003699_abnormal_female_reproductive0.66258688
83MP0000631_abnormal_neuroendocrine_gland0.65904653
84MP0003880_abnormal_central_pattern0.65772279
85MP0000313_abnormal_cell_death0.65574473
86MP0002269_muscular_atrophy0.65153152
87MP0000350_abnormal_cell_proliferation0.64823950
88MP0003119_abnormal_digestive_system0.64406875
89MP0001661_extended_life_span0.63858009
90MP0002089_abnormal_postnatal_growth/wei0.63579178
91MP0002184_abnormal_innervation0.63453119
92MP0002084_abnormal_developmental_patter0.63018876
93MP0002102_abnormal_ear_morphology0.62479085
94MP0002693_abnormal_pancreas_physiology0.60604362
95MP0005395_other_phenotype0.60323163
96MP0004133_heterotaxia0.57152762
97MP0002088_abnormal_embryonic_growth/wei0.56846642
98MP0003984_embryonic_growth_retardation0.56662678
99MP0008789_abnormal_olfactory_epithelium0.55339013
100MP0005195_abnormal_posterior_eye0.54287100

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)9.24498885
2Abnormality of B cell number (HP:0010975)8.55851412
3IgM deficiency (HP:0002850)7.35062154
4Oligodactyly (hands) (HP:0001180)5.97483935
5Hypoplastic pelvis (HP:0008839)5.34921427
6Fibular aplasia (HP:0002990)4.66479153
7Split foot (HP:0001839)4.27407842
8Abnormality of alanine metabolism (HP:0010916)4.20615521
9Hyperalaninemia (HP:0003348)4.20615521
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.20615521
11Oligodactyly (HP:0012165)4.10259832
12Aplasia/hypoplasia of the uterus (HP:0008684)3.91504301
13IgG deficiency (HP:0004315)3.71129383
14Posterior subcapsular cataract (HP:0007787)3.70737965
15Humeroradial synostosis (HP:0003041)3.68985518
16Synostosis involving the elbow (HP:0003938)3.68985518
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.65686503
18Adactyly (HP:0009776)3.63555534
19IgA deficiency (HP:0002720)3.54174639
20Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.47013391
21Abnormality of T cell physiology (HP:0011840)3.45600685
22Albinism (HP:0001022)3.38979758
23Hepatocellular necrosis (HP:0001404)3.34494277
24Type II lissencephaly (HP:0007260)3.34422731
25Increased intramyocellular lipid droplets (HP:0012240)3.04762665
26Gonadotropin excess (HP:0000837)2.96061467
27Radial bowing (HP:0002986)2.94853066
28Recurrent sinusitis (HP:0011108)2.93728261
29Abnormal mitochondria in muscle tissue (HP:0008316)2.90274202
30Severe visual impairment (HP:0001141)2.87999381
31Hepatic necrosis (HP:0002605)2.86121232
32Gastrointestinal stroma tumor (HP:0100723)2.84260479
33Barrel-shaped chest (HP:0001552)2.80003574
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70257400
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70257400
36Increased CSF lactate (HP:0002490)2.67975073
37Cerebellar dysplasia (HP:0007033)2.62728862
38Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.62529682
39Mitochondrial inheritance (HP:0001427)2.62106382
40Recurrent bronchitis (HP:0002837)2.58999309
41Hypoplastic iliac wings (HP:0002866)2.58451349
42Autoimmune thrombocytopenia (HP:0001973)2.56450616
43Patellar aplasia (HP:0006443)2.56361605
44Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.52198615
45Increased muscle lipid content (HP:0009058)2.44769995
46Esophageal neoplasm (HP:0100751)2.44062098
47Neoplasm of head and neck (HP:0012288)2.44062098
48Congenital stationary night blindness (HP:0007642)2.38639957
49Delayed epiphyseal ossification (HP:0002663)2.37750288
50Abnormality of the peritoneum (HP:0002585)2.34987237
51Hemivertebrae (HP:0002937)2.34951219
52Fair hair (HP:0002286)2.34526128
53Abnormal finger flexion creases (HP:0006143)2.33110588
54Femoral bowing (HP:0002980)2.32730272
55Aplasia/Hypoplasia of the patella (HP:0006498)2.32269097
56Rhabdomyosarcoma (HP:0002859)2.31294393
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.23246871
58Hypoplasia of the fovea (HP:0007750)2.23246871
59Pendular nystagmus (HP:0012043)2.21750756
60Symphalangism affecting the phalanges of the hand (HP:0009773)2.20676652
61Absent forearm bone (HP:0003953)2.19689419
62Aplasia involving forearm bones (HP:0009822)2.19689419
63Abnormal spermatogenesis (HP:0008669)2.19525366
64Generalized hypopigmentation of hair (HP:0011358)2.15645634
65Ragged-red muscle fibers (HP:0003200)2.14346838
66Abnormality of the pons (HP:0007361)2.11715493
67Thin bony cortex (HP:0002753)2.09884221
68Recurrent pneumonia (HP:0006532)2.06735103
69Enlarged epiphyses (HP:0010580)2.05279573
70Elevated erythrocyte sedimentation rate (HP:0003565)2.03114382
71Increased serum lactate (HP:0002151)2.02631203
72Abnormality of the pubic bones (HP:0003172)2.02582011
73Type 2 muscle fiber atrophy (HP:0003554)2.01661328
74Subcapsular cataract (HP:0000523)2.01173732
75Abnormal rod and cone electroretinograms (HP:0008323)1.98730988
76Hypoplastic nipples (HP:0002557)1.96341227
77Hypoplasia of the pons (HP:0012110)1.94851204
78Lymphopenia (HP:0001888)1.94602971
79Aplasia/Hypoplasia of the fibula (HP:0006492)1.92094186
80Retinal dysplasia (HP:0007973)1.91116836
81Abnormality of the fovea (HP:0000493)1.88673974
82Hypoplasia of the radius (HP:0002984)1.87074608
83Meningocele (HP:0002435)1.86907011
84Skull defect (HP:0001362)1.85688947
85Abnormality of serum amino acid levels (HP:0003112)1.83972031
86Aplasia/Hypoplasia of the ulna (HP:0006495)1.81874353
87Abnormality of the costochondral junction (HP:0000919)1.81142578
88Bowing of the arm (HP:0006488)1.77322345
89Bowed forearm bones (HP:0003956)1.77322345
90Broad ribs (HP:0000885)1.76258562
91Bronchiectasis (HP:0002110)1.73537768
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.70705713
93Mediastinal lymphadenopathy (HP:0100721)1.70180304
94Methylmalonic aciduria (HP:0012120)1.68985574
95Abnormality of T cells (HP:0002843)1.67625037
96Neoplasm of striated muscle (HP:0009728)1.67347061
97Mesangial abnormality (HP:0001966)1.66226291
983-Methylglutaconic aciduria (HP:0003535)1.64070560
99Stomatitis (HP:0010280)1.63569093
100Abnormality of the fibula (HP:0002991)1.62563627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K97.18665601
2ARAF5.48681061
3MAP3K134.96086713
4NLK3.57264476
5CSNK1G13.53495387
6PRKCI2.81450092
7KSR22.56976126
8CSNK1G32.47390789
9CSNK1A1L2.26028429
10MAPK112.25868178
11BRAF2.09052229
12CSNK1G22.04580100
13MOS2.04106587
14KSR11.93389016
15RAF11.83203533
16ZAK1.52174529
17TNIK1.46133665
18PBK1.43385581
19GRK11.43022606
20ADRBK21.35932191
21CSK1.28660100
22SGK21.25558815
23PLK41.22124819
24IRAK11.20942644
25MAP4K21.18754438
26CASK1.15129616
27FRK1.12198788
28WNK41.10224862
29MAP3K41.02061859
30EPHA31.01891952
31TTK0.96700528
32BMPR1B0.94843306
33TEC0.88867612
34PRKCG0.87916560
35CHEK20.83986032
36BRSK20.79564771
37FGFR20.76532512
38EPHA40.75681799
39NEK10.75573142
40ATR0.75028963
41SGK2230.73276549
42SGK4940.73276549
43STK390.71266791
44ACVR1B0.69628176
45SRPK10.68443431
46SCYL20.66162101
47MST40.66130876
48BUB10.64719908
49MAP2K10.64506478
50NTRK20.63012429
51IKBKE0.62650086
52MKNK20.60138765
53SGK30.58466356
54CDC70.58459318
55VRK10.58319323
56MAP2K70.54554753
57MAPK130.54042518
58EIF2AK10.52348221
59TRIM280.52326951
60NME10.51502627
61PRKCE0.51469201
62DYRK1A0.51281883
63MKNK10.50877775
64CDK40.50664764
65STK30.49680486
66PLK30.48975024
67WNK30.48602782
68DYRK20.47194689
69PLK10.46461989
70VRK20.46283882
71WEE10.44555410
72DAPK20.43187391
73MAP3K80.42649449
74SYK0.42390916
75CSNK1D0.42370582
76MARK10.40249946
77OXSR10.40246019
78CSNK1A10.39027196
79PAK10.38097844
80BCKDK0.37236847
81CDK10.35650258
82CHEK10.35332297
83ADRBK10.33937712
84ITK0.33161811
85ATM0.31932342
86AURKB0.30788761
87STK38L0.30530885
88TGFBR10.28575036
89AURKA0.28211926
90MAPK90.27639547
91CSNK1E0.26172180
92GSK3B0.24199050
93PRKCA0.24192579
94TAOK30.23399700
95NUAK10.20603680
96CDK20.19899456
97EIF2AK30.19825063
98TYRO30.19312660
99FGFR40.19230325
100PINK10.18757709

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.82803306
2Basal transcription factors_Homo sapiens_hsa030223.68266317
3Proteasome_Homo sapiens_hsa030503.54863463
4Steroid biosynthesis_Homo sapiens_hsa001002.50429685
5Selenocompound metabolism_Homo sapiens_hsa004502.44377411
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.44233852
7Nucleotide excision repair_Homo sapiens_hsa034202.17460407
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16736750
9RNA polymerase_Homo sapiens_hsa030202.04832266
10Oxidative phosphorylation_Homo sapiens_hsa001902.03391153
11Fanconi anemia pathway_Homo sapiens_hsa034602.00360721
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99338801
13Base excision repair_Homo sapiens_hsa034101.93591528
14Caffeine metabolism_Homo sapiens_hsa002321.88841716
15DNA replication_Homo sapiens_hsa030301.86737901
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86630643
17Homologous recombination_Homo sapiens_hsa034401.84587068
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75452441
19RNA degradation_Homo sapiens_hsa030181.71034175
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67239568
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63713509
22Ether lipid metabolism_Homo sapiens_hsa005651.63449205
23Folate biosynthesis_Homo sapiens_hsa007901.60457645
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.59762106
25T cell receptor signaling pathway_Homo sapiens_hsa046601.57486817
26Parkinsons disease_Homo sapiens_hsa050121.57257972
27One carbon pool by folate_Homo sapiens_hsa006701.56443319
28Nitrogen metabolism_Homo sapiens_hsa009101.54526923
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48030493
30Linoleic acid metabolism_Homo sapiens_hsa005911.43480028
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34952217
32Phototransduction_Homo sapiens_hsa047441.32235703
33Butanoate metabolism_Homo sapiens_hsa006501.31819190
34Protein export_Homo sapiens_hsa030601.29268866
35Huntingtons disease_Homo sapiens_hsa050161.28732863
36RNA transport_Homo sapiens_hsa030131.26588145
37Purine metabolism_Homo sapiens_hsa002301.25770146
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20343688
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.20194065
40Mismatch repair_Homo sapiens_hsa034301.18306478
41p53 signaling pathway_Homo sapiens_hsa041151.16833976
42Propanoate metabolism_Homo sapiens_hsa006401.13831886
43Pyrimidine metabolism_Homo sapiens_hsa002401.11220129
44Non-homologous end-joining_Homo sapiens_hsa034501.08256028
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.05399793
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05309742
47Fatty acid elongation_Homo sapiens_hsa000621.04059340
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97551438
49Alzheimers disease_Homo sapiens_hsa050100.96151688
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88098189
51Cell cycle_Homo sapiens_hsa041100.83700361
52Hedgehog signaling pathway_Homo sapiens_hsa043400.82729638
53Spliceosome_Homo sapiens_hsa030400.81890484
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80910992
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79437890
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78483659
57Collecting duct acid secretion_Homo sapiens_hsa049660.74661338
58Sulfur metabolism_Homo sapiens_hsa009200.73806746
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73705110
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71285596
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69520026
62Metabolic pathways_Homo sapiens_hsa011000.69407656
63Arginine and proline metabolism_Homo sapiens_hsa003300.68442515
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65104790
65Dorso-ventral axis formation_Homo sapiens_hsa043200.63768983
66Glycerolipid metabolism_Homo sapiens_hsa005610.62643974
67Ribosome_Homo sapiens_hsa030100.60745767
68Sulfur relay system_Homo sapiens_hsa041220.58506564
69Basal cell carcinoma_Homo sapiens_hsa052170.58024897
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56374233
71Fatty acid biosynthesis_Homo sapiens_hsa000610.51606086
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50384989
73Prion diseases_Homo sapiens_hsa050200.49065212
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44779453
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44292345
76TGF-beta signaling pathway_Homo sapiens_hsa043500.41489193
77Peroxisome_Homo sapiens_hsa041460.41297755
78Oocyte meiosis_Homo sapiens_hsa041140.41109644
79Lysine degradation_Homo sapiens_hsa003100.41082874
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40069595
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37826919
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37819363
83Nicotine addiction_Homo sapiens_hsa050330.37092924
84Regulation of autophagy_Homo sapiens_hsa041400.35918455
85Taste transduction_Homo sapiens_hsa047420.34830537
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.34271544
87Ovarian steroidogenesis_Homo sapiens_hsa049130.31389814
88ABC transporters_Homo sapiens_hsa020100.30863860
89Fat digestion and absorption_Homo sapiens_hsa049750.30409311
90Fructose and mannose metabolism_Homo sapiens_hsa000510.28883680
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27499835
92Hippo signaling pathway_Homo sapiens_hsa043900.27421674
93Tryptophan metabolism_Homo sapiens_hsa003800.26786190
94Arginine biosynthesis_Homo sapiens_hsa002200.26633490
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25892562
96Fatty acid metabolism_Homo sapiens_hsa012120.25162744
97Long-term depression_Homo sapiens_hsa047300.24975169
98Choline metabolism in cancer_Homo sapiens_hsa052310.22717091
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20701719
100Wnt signaling pathway_Homo sapiens_hsa043100.20453325

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