ZNF770

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.81975080
2chromatin remodeling at centromere (GO:0031055)4.11980315
3CENP-A containing nucleosome assembly (GO:0034080)4.02762497
4establishment of integrated proviral latency (GO:0075713)3.99824530
5nuclear pore complex assembly (GO:0051292)3.95341032
6mitotic sister chromatid cohesion (GO:0007064)3.85063815
7nuclear pore organization (GO:0006999)3.82351474
8protein localization to kinetochore (GO:0034501)3.73689309
9regulation of helicase activity (GO:0051095)3.65353355
10DNA replication-independent nucleosome assembly (GO:0006336)3.55575167
11DNA replication-independent nucleosome organization (GO:0034724)3.55575167
12regulation of mitotic spindle checkpoint (GO:1903504)3.54976370
13regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.54976370
14negative regulation of DNA recombination (GO:0045910)3.52432710
15somatic hypermutation of immunoglobulin genes (GO:0016446)3.48098355
16somatic diversification of immune receptors via somatic mutation (GO:0002566)3.48098355
17L-serine metabolic process (GO:0006563)3.46518429
18histone exchange (GO:0043486)3.44943394
19pre-miRNA processing (GO:0031054)3.43263765
20non-recombinational repair (GO:0000726)3.39070243
21double-strand break repair via nonhomologous end joining (GO:0006303)3.39070243
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.33547070
23DNA replication-dependent nucleosome organization (GO:0034723)3.28304663
24DNA replication-dependent nucleosome assembly (GO:0006335)3.28304663
25negative regulation of mitotic sister chromatid separation (GO:2000816)3.25365966
26negative regulation of sister chromatid segregation (GO:0033046)3.25365966
27negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25365966
28negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25365966
29negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25365966
30mitotic metaphase plate congression (GO:0007080)3.18696867
31negative regulation of chromosome segregation (GO:0051985)3.18599303
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18540758
33DNA replication checkpoint (GO:0000076)3.15394383
34regulation of centriole replication (GO:0046599)3.14107679
35spindle checkpoint (GO:0031577)3.13167708
36mitotic spindle checkpoint (GO:0071174)3.13126438
37DNA damage response, detection of DNA damage (GO:0042769)3.07355734
38regulation of gene silencing by RNA (GO:0060966)3.06191506
39regulation of posttranscriptional gene silencing (GO:0060147)3.06191506
40regulation of gene silencing by miRNA (GO:0060964)3.06191506
41regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03766757
42regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03766757
43IMP biosynthetic process (GO:0006188)3.01494251
44regulation of DNA endoreduplication (GO:0032875)3.00437130
45metaphase plate congression (GO:0051310)3.00393704
46protein localization to chromosome, centromeric region (GO:0071459)3.00347405
47mitotic spindle assembly checkpoint (GO:0007094)2.99863592
48regulation of sister chromatid segregation (GO:0033045)2.98635753
49regulation of mitotic sister chromatid separation (GO:0010965)2.98635753
50regulation of mitotic sister chromatid segregation (GO:0033047)2.98635753
51spindle assembly checkpoint (GO:0071173)2.97735218
52DNA ligation (GO:0006266)2.96504313
53kinetochore organization (GO:0051383)2.90548346
54pore complex assembly (GO:0046931)2.89166046
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87021936
56negative regulation of translation, ncRNA-mediated (GO:0040033)2.87021936
57regulation of translation, ncRNA-mediated (GO:0045974)2.87021936
58regulation of chromosome segregation (GO:0051983)2.85926988
59establishment of viral latency (GO:0019043)2.76191794
60ATP-dependent chromatin remodeling (GO:0043044)2.74407814
61paraxial mesoderm development (GO:0048339)2.74229356
62protein complex localization (GO:0031503)2.73625818
63regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.72141146
64IMP metabolic process (GO:0046040)2.71077017
65regulation of coenzyme metabolic process (GO:0051196)2.69894058
66regulation of cofactor metabolic process (GO:0051193)2.69894058
67telomere maintenance via telomerase (GO:0007004)2.69893751
68presynaptic membrane assembly (GO:0097105)2.69789027
69DNA strand elongation involved in DNA replication (GO:0006271)2.69046316
70ribosome assembly (GO:0042255)2.65931400
71replication fork processing (GO:0031297)2.65461630
72somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65030117
73somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65030117
74isotype switching (GO:0045190)2.65030117
75RNA-dependent DNA replication (GO:0006278)2.64908043
76histone mRNA metabolic process (GO:0008334)2.64821902
77regulation of histone H3-K9 methylation (GO:0051570)2.63943700
78mitotic G2/M transition checkpoint (GO:0044818)2.62894119
79purine nucleobase biosynthetic process (GO:0009113)2.62703308
80somatic recombination of immunoglobulin gene segments (GO:0016447)2.61521140
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.59970384
82DNA catabolic process, exonucleolytic (GO:0000738)2.59229619
83sister chromatid segregation (GO:0000819)2.58508023
84response to X-ray (GO:0010165)2.57193495
85attachment of spindle microtubules to kinetochore (GO:0008608)2.57091280
86DNA strand elongation (GO:0022616)2.56211726
87cullin deneddylation (GO:0010388)2.51268327
88regulation of acyl-CoA biosynthetic process (GO:0050812)2.49401434
89negative regulation of mitosis (GO:0045839)2.49095553
90mitotic sister chromatid segregation (GO:0000070)2.47696980
91DNA unwinding involved in DNA replication (GO:0006268)2.47658911
92cellular protein complex localization (GO:0034629)2.47275901
93telomere maintenance via semi-conservative replication (GO:0032201)2.46572106
94dorsal/ventral axis specification (GO:0009950)2.44257253
95ribonucleoprotein complex disassembly (GO:0032988)2.43259715
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41702086
97regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.41245146
98resolution of meiotic recombination intermediates (GO:0000712)2.41093374
99mitotic recombination (GO:0006312)2.41042469
100kinetochore assembly (GO:0051382)2.41011062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.55359166
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.40208813
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08796500
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90553292
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65578569
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59435609
7FUS_26573619_Chip-Seq_HEK293_Human2.53159874
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44919111
9IGF1R_20145208_ChIP-Seq_DFB_Human2.34816054
10EWS_26573619_Chip-Seq_HEK293_Human2.28204448
11TAF15_26573619_Chip-Seq_HEK293_Human2.20085397
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20034437
13ELK1_19687146_ChIP-ChIP_HELA_Human2.18643435
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11154386
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.05384378
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.03724297
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.95737616
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95737602
19POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88610761
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.86207996
21AR_21909140_ChIP-Seq_LNCAP_Human1.85635047
22ZNF274_21170338_ChIP-Seq_K562_Hela1.83497569
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81690808
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81422329
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.80632164
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78954025
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78342541
28P300_19829295_ChIP-Seq_ESCs_Human1.77031590
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75693805
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71643160
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71045461
32GBX2_23144817_ChIP-Seq_PC3_Human1.70911835
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68725928
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67939870
35* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62596068
36NANOG_16153702_ChIP-ChIP_HESCs_Human1.52071908
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51055282
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.48801909
39SOX2_16153702_ChIP-ChIP_HESCs_Human1.47543381
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.47305456
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45406200
42SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.43218424
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42407845
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42254436
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40040159
46VDR_22108803_ChIP-Seq_LS180_Human1.39914859
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39468052
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39183193
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38025331
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37461482
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37050538
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36320772
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32906834
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32793140
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32354201
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32232440
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31994974
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31994974
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31994974
60MYC_18940864_ChIP-ChIP_HL60_Human1.31813094
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29693374
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29040823
63* VDR_23849224_ChIP-Seq_CD4+_Human1.28200620
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25513453
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22309993
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21594171
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19472387
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17137200
69IRF1_19129219_ChIP-ChIP_H3396_Human1.14886142
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14580527
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.13346507
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13072203
73SMAD4_21799915_ChIP-Seq_A2780_Human1.12609519
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12007574
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.10163497
76* FOXP3_21729870_ChIP-Seq_TREG_Human1.08964994
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07904391
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07322718
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07275568
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.06301670
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05759684
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04464218
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.03486738
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02781115
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02661523
86SOX9_26525672_Chip-Seq_HEART_Mouse1.01989984
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01726167
88TTF2_22483619_ChIP-Seq_HELA_Human1.01607430
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00957510
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00102307
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99233144
92E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98749068
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.98630372
94STAT3_23295773_ChIP-Seq_U87_Human0.98604013
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97960578
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97948970
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97578800
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97003632
99RNF2_27304074_Chip-Seq_NSC_Mouse0.96222426
100ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95891424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry3.53011204
2MP0008057_abnormal_DNA_replication3.14335495
3MP0003941_abnormal_skin_development2.90567466
4MP0010094_abnormal_chromosome_stability2.75818240
5MP0006292_abnormal_olfactory_placode2.59813703
6MP0001188_hyperpigmentation2.57222912
7MP0008877_abnormal_DNA_methylation2.54882390
8MP0004957_abnormal_blastocyst_morpholog2.45568836
9MP0008058_abnormal_DNA_repair2.35520277
10MP0003693_abnormal_embryo_hatching2.31927576
11MP0001529_abnormal_vocalization2.18038097
12MP0003121_genomic_imprinting2.17799558
13MP0003787_abnormal_imprinting2.11067349
14MP0003122_maternal_imprinting2.08449159
15MP0003567_abnormal_fetal_cardiomyocyte1.98325914
16MP0008932_abnormal_embryonic_tissue1.95886794
17MP0003111_abnormal_nucleus_morphology1.93297294
18MP0001293_anophthalmia1.86013497
19MP0003077_abnormal_cell_cycle1.83594176
20MP0002254_reproductive_system_inflammat1.80862648
21MP0003937_abnormal_limbs/digits/tail_de1.78251449
22MP0003880_abnormal_central_pattern1.78234694
23MP0003221_abnormal_cardiomyocyte_apopto1.63609261
24MP0003119_abnormal_digestive_system1.63011440
25MP0000579_abnormal_nail_morphology1.55765514
26MP0001984_abnormal_olfaction1.53292032
27MP0004133_heterotaxia1.52697228
28MP0009697_abnormal_copulation1.48552916
29MP0009672_abnormal_birth_weight1.45862991
30MP0002234_abnormal_pharynx_morphology1.42168730
31MP0002084_abnormal_developmental_patter1.40777837
32MP0000778_abnormal_nervous_system1.36832278
33MP0005499_abnormal_olfactory_system1.34807804
34MP0005394_taste/olfaction_phenotype1.34807804
35MP0002233_abnormal_nose_morphology1.34278812
36MP0001730_embryonic_growth_arrest1.31451141
37MP0005187_abnormal_penis_morphology1.31237796
38MP0004197_abnormal_fetal_growth/weight/1.30877981
39MP0009703_decreased_birth_body1.29965790
40MP0006072_abnormal_retinal_apoptosis1.29962686
41MP0002697_abnormal_eye_size1.27591562
42MP0001286_abnormal_eye_development1.27293322
43MP0001177_atelectasis1.24764495
44MP0000647_abnormal_sebaceous_gland1.24065452
45MP0008789_abnormal_olfactory_epithelium1.23972968
46MP0005380_embryogenesis_phenotype1.22364975
47MP0001672_abnormal_embryogenesis/_devel1.22364975
48MP0004859_abnormal_synaptic_plasticity1.22312704
49MP0002009_preneoplasia1.19654172
50MP0005248_abnormal_Harderian_gland1.19173003
51MP0002085_abnormal_embryonic_tissue1.18886488
52MP0000049_abnormal_middle_ear1.17034938
53MP0010352_gastrointestinal_tract_polyps1.13528979
54MP0003718_maternal_effect1.13085488
55MP0002938_white_spotting1.13011093
56MP0008007_abnormal_cellular_replicative1.12847017
57MP0003861_abnormal_nervous_system1.10650178
58MP0004270_analgesia1.10558180
59MP0001697_abnormal_embryo_size1.08760050
60MP0002102_abnormal_ear_morphology1.08632185
61MP0003755_abnormal_palate_morphology1.08040908
62MP0001299_abnormal_eye_distance/1.06147127
63MP0006035_abnormal_mitochondrial_morpho1.06002453
64MP0000350_abnormal_cell_proliferation1.04893554
65MP0003136_yellow_coat_color1.04853015
66MP0003984_embryonic_growth_retardation1.04102877
67MP0002796_impaired_skin_barrier1.02535582
68MP0002088_abnormal_embryonic_growth/wei1.01758696
69MP0002751_abnormal_autonomic_nervous0.99350545
70MP0000631_abnormal_neuroendocrine_gland0.93752734
71MP0003315_abnormal_perineum_morphology0.92715538
72MP0010234_abnormal_vibrissa_follicle0.91580420
73MP0003123_paternal_imprinting0.91154903
74MP0000428_abnormal_craniofacial_morphol0.90458175
75MP0003385_abnormal_body_wall0.90049577
76MP0005367_renal/urinary_system_phenotyp0.89404279
77MP0000516_abnormal_urinary_system0.89404279
78MP0000537_abnormal_urethra_morphology0.88264458
79MP0002111_abnormal_tail_morphology0.88225174
80MP0004215_abnormal_myocardial_fiber0.88169043
81MP0002090_abnormal_vision0.88117244
82MP0002736_abnormal_nociception_after0.87934516
83MP0002092_abnormal_eye_morphology0.87350415
84MP0001486_abnormal_startle_reflex0.85042718
85MP0001485_abnormal_pinna_reflex0.84685640
86MP0006276_abnormal_autonomic_nervous0.83741093
87MP0005391_vision/eye_phenotype0.82229736
88MP0005253_abnormal_eye_physiology0.81901086
89MP0002080_prenatal_lethality0.81746542
90MP0000955_abnormal_spinal_cord0.80896082
91MP0009046_muscle_twitch0.80236407
92MP0002081_perinatal_lethality0.77668760
93MP0003935_abnormal_craniofacial_develop0.75113697
94MP0002152_abnormal_brain_morphology0.74755480
95MP0002210_abnormal_sex_determination0.74161697
96MP0000432_abnormal_head_morphology0.73814332
97MP0010678_abnormal_skin_adnexa0.73651576
98MP0004147_increased_porphyrin_level0.73104466
99MP0002184_abnormal_innervation0.72928648
100MP0000427_abnormal_hair_cycle0.70992864

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.74804816
2Colon cancer (HP:0003003)3.57310532
3Volvulus (HP:0002580)3.19547759
4Hepatoblastoma (HP:0002884)3.19272203
5Cortical dysplasia (HP:0002539)3.14619396
6Medulloblastoma (HP:0002885)2.79783904
7Embryonal renal neoplasm (HP:0011794)2.77258785
8Nephroblastoma (Wilms tumor) (HP:0002667)2.74381441
9Abnormality of chromosome stability (HP:0003220)2.71947384
10Rhabdomyosarcoma (HP:0002859)2.63859625
11Chromsome breakage (HP:0040012)2.55573114
12Septo-optic dysplasia (HP:0100842)2.53539655
13Abnormal lung lobation (HP:0002101)2.52185829
14Hyperglycinemia (HP:0002154)2.47425649
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46580009
16Papillary thyroid carcinoma (HP:0002895)2.37802528
17Meckel diverticulum (HP:0002245)2.37692497
18Ependymoma (HP:0002888)2.34557645
19Abnormality of the ileum (HP:0001549)2.27597518
20Drooling (HP:0002307)2.26329199
21Glioma (HP:0009733)2.22585053
22Birth length less than 3rd percentile (HP:0003561)2.20618435
23Intestinal atresia (HP:0011100)2.17941425
24Aplasia/Hypoplasia of the sternum (HP:0006714)2.15034293
25Failure to thrive in infancy (HP:0001531)2.13655955
26Exercise-induced muscle cramps (HP:0003710)2.13497061
27Abnormality of the astrocytes (HP:0100707)2.12230860
28Astrocytoma (HP:0009592)2.12230860
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.11212286
30Abnormal hair whorl (HP:0010721)2.11065047
31Biliary tract neoplasm (HP:0100574)2.09279214
32Stenosis of the external auditory canal (HP:0000402)2.06172060
33Neoplasm of the oral cavity (HP:0100649)2.04526158
34Genital tract atresia (HP:0001827)2.03595996
35Hypoplastic female external genitalia (HP:0012815)1.99822399
36Excessive salivation (HP:0003781)1.98659011
37Labial hypoplasia (HP:0000066)1.97928574
38Vaginal atresia (HP:0000148)1.92647969
39Abnormality of the preputium (HP:0100587)1.92010919
40Shoulder girdle muscle weakness (HP:0003547)1.91580714
41Duodenal stenosis (HP:0100867)1.90762216
42Small intestinal stenosis (HP:0012848)1.90762216
43Abnormality of serum amino acid levels (HP:0003112)1.89973956
44Abnormality of glycine metabolism (HP:0010895)1.89806703
45Abnormality of serine family amino acid metabolism (HP:0010894)1.89806703
46Spastic diplegia (HP:0001264)1.89178576
47Neoplasm of the small intestine (HP:0100833)1.88523989
48Gait imbalance (HP:0002141)1.88109117
49Myelomeningocele (HP:0002475)1.87468405
50Pancreatic islet-cell hyperplasia (HP:0004510)1.86540591
51Congenital primary aphakia (HP:0007707)1.86422714
52Abnormality of the duodenum (HP:0002246)1.86218643
53Aplasia involving forearm bones (HP:0009822)1.84730518
54Absent forearm bone (HP:0003953)1.84730518
55Bifid tongue (HP:0010297)1.83043442
56Increased nuchal translucency (HP:0010880)1.82026661
57Absent radius (HP:0003974)1.81879645
58Neoplasm of the colon (HP:0100273)1.81594920
59Abnormality of the septum pellucidum (HP:0007375)1.81591725
60Postnatal microcephaly (HP:0005484)1.81450991
61Oligodactyly (hands) (HP:0001180)1.80673262
62Scrotal hypoplasia (HP:0000046)1.80103141
63Broad foot (HP:0001769)1.79501100
64Sloping forehead (HP:0000340)1.79235402
65Split foot (HP:0001839)1.77971260
66Median cleft lip (HP:0000161)1.76803811
67Abnormality of the hip-girdle musculature (HP:0001445)1.76638154
68Abnormality of the musculature of the pelvis (HP:0001469)1.76638154
69Supernumerary spleens (HP:0009799)1.76531197
70Thyroid carcinoma (HP:0002890)1.75985917
71Hyperglycinuria (HP:0003108)1.74819520
72Embryonal neoplasm (HP:0002898)1.73787286
73Micropenis (HP:0000054)1.73657456
74Hypoplastic pelvis (HP:0008839)1.73109518
75Medial flaring of the eyebrow (HP:0010747)1.71907754
76Agnosia (HP:0010524)1.71811013
77Poor coordination (HP:0002370)1.71588847
78Impaired vibration sensation in the lower limbs (HP:0002166)1.71085416
79Gastrointestinal atresia (HP:0002589)1.70779807
80Broad alveolar ridges (HP:0000187)1.70386588
81Atonic seizures (HP:0010819)1.68673145
82Aqueductal stenosis (HP:0002410)1.68176388
83Renal hypoplasia (HP:0000089)1.67590948
84Neoplasm of striated muscle (HP:0009728)1.65722842
85Gastrointestinal carcinoma (HP:0002672)1.65488340
86Malignant gastrointestinal tract tumors (HP:0006749)1.65488340
87Optic nerve hypoplasia (HP:0000609)1.65111708
88Hyperinsulinemic hypoglycemia (HP:0000825)1.65005659
89Nephrogenic diabetes insipidus (HP:0009806)1.63911522
90Neoplasm of the adrenal cortex (HP:0100641)1.63206736
91Absent eyebrow (HP:0002223)1.62864681
92Methylmalonic acidemia (HP:0002912)1.62698650
93Absent septum pellucidum (HP:0001331)1.62694569
94Gonadotropin excess (HP:0000837)1.62065855
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60772221
96Breast carcinoma (HP:0003002)1.60569297
97Pelvic girdle muscle weakness (HP:0003749)1.60138514
98Triphalangeal thumb (HP:0001199)1.59744411
99Absent hair (HP:0002298)1.59426379
100Ovarian neoplasm (HP:0100615)1.58453763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK2.89599313
2SRPK12.84382161
3MKNK22.73100590
4CDC72.68439797
5CASK2.59995939
6BCR2.57260651
7TSSK62.50411636
8MAP3K42.49179287
9MKNK12.44944610
10TTK2.37163671
11WNK32.35560283
12TRIM282.33699043
13NEK12.23925507
14BUB12.23881322
15TAF12.13266773
16ERBB31.93863235
17PLK41.92524367
18STK38L1.91254820
19PLK31.90246032
20PBK1.88439931
21MAP2K71.71984848
22EIF2AK31.67752568
23MAP4K21.67004018
24BRD41.62408493
25ZAK1.56946231
26WEE11.51771914
27NUAK11.51316677
28PNCK1.47142084
29ACVR1B1.46825403
30CDK191.36987799
31MST41.33643114
32CSNK1G11.30208505
33DYRK31.30000165
34PLK21.28168129
35CSNK1G21.26279924
36PLK11.25634684
37BRSK21.24722944
38MAPK131.19360053
39STK241.17418214
40BMPR1B1.14218540
41FGFR11.07195077
42LATS11.06105687
43CSNK1A1L1.04875844
44CSNK1G31.03839841
45MARK10.96584077
46STK30.93173085
47LATS20.93108090
48EIF2AK20.91541497
49DYRK20.90218111
50ATR0.89651599
51ATM0.88677749
52PASK0.79922086
53RPS6KA40.79682503
54VRK10.79134255
55CHEK20.76549074
56ERBB40.74896067
57EIF2AK10.74087340
58UHMK10.67805963
59CHEK10.67262709
60DYRK1A0.67018067
61STK160.66712369
62NEK20.66136552
63CSNK1E0.66047157
64MAP2K40.64973252
65CAMK1G0.64900191
66PINK10.63054663
67EPHA40.62884326
68MINK10.62532795
69YES10.61320011
70FLT30.60424696
71MAP3K60.60009452
72STK390.59880167
73ALK0.57978824
74AURKB0.57471081
75TGFBR10.56935454
76MAP3K100.56354397
77AKT30.54976108
78PRKDC0.53231696
79PRKCG0.49564542
80CDK60.48633196
81CDK10.48415875
82OXSR10.48251797
83PRKCE0.44536501
84CAMK1D0.44285254
85NLK0.43128033
86DMPK0.42015806
87CDK20.41031849
88OBSCN0.40255730
89CDK180.38827364
90NME10.37784376
91CSNK1D0.35942736
92CDK140.35677524
93KSR10.35528647
94BRSK10.35189566
95WNK40.34523627
96CSNK2A20.33609524
97PAK30.33249625
98FRK0.32221892
99PRKACB0.32138949
100NTRK20.31993944

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.20401028
2Mismatch repair_Homo sapiens_hsa034303.00964248
3Protein export_Homo sapiens_hsa030602.70793768
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47475370
5DNA replication_Homo sapiens_hsa030302.43872489
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.43692976
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43598259
8Propanoate metabolism_Homo sapiens_hsa006402.35098953
9Basal transcription factors_Homo sapiens_hsa030222.32085371
10RNA transport_Homo sapiens_hsa030132.31971373
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15308315
12Steroid biosynthesis_Homo sapiens_hsa001002.13323239
13Fanconi anemia pathway_Homo sapiens_hsa034602.12988270
14Cysteine and methionine metabolism_Homo sapiens_hsa002702.10923500
15Cell cycle_Homo sapiens_hsa041102.10085659
16Spliceosome_Homo sapiens_hsa030402.03969433
17RNA degradation_Homo sapiens_hsa030181.94150114
18mRNA surveillance pathway_Homo sapiens_hsa030151.91047766
19Homologous recombination_Homo sapiens_hsa034401.80567161
20Nicotine addiction_Homo sapiens_hsa050331.69156287
21Nucleotide excision repair_Homo sapiens_hsa034201.62811367
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55116332
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53956586
24Pyruvate metabolism_Homo sapiens_hsa006201.53093105
25RNA polymerase_Homo sapiens_hsa030201.50859818
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49235743
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47837066
28Oocyte meiosis_Homo sapiens_hsa041141.42121357
29Vitamin B6 metabolism_Homo sapiens_hsa007501.40689469
30One carbon pool by folate_Homo sapiens_hsa006701.38866944
31Selenocompound metabolism_Homo sapiens_hsa004501.27645797
32Proteasome_Homo sapiens_hsa030501.25520760
33Base excision repair_Homo sapiens_hsa034101.19732993
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18944323
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18729178
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14417827
37Biosynthesis of amino acids_Homo sapiens_hsa012301.12251791
38Hippo signaling pathway_Homo sapiens_hsa043901.01070717
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00480197
40Basal cell carcinoma_Homo sapiens_hsa052170.99006288
41Wnt signaling pathway_Homo sapiens_hsa043100.95477086
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92085004
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91416496
44Butanoate metabolism_Homo sapiens_hsa006500.90999183
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89400822
46Taste transduction_Homo sapiens_hsa047420.88523912
47Fatty acid elongation_Homo sapiens_hsa000620.86805390
48p53 signaling pathway_Homo sapiens_hsa041150.83870009
49Hedgehog signaling pathway_Homo sapiens_hsa043400.82786069
50Carbon metabolism_Homo sapiens_hsa012000.82240751
51GABAergic synapse_Homo sapiens_hsa047270.79175614
52TGF-beta signaling pathway_Homo sapiens_hsa043500.78948285
53Pyrimidine metabolism_Homo sapiens_hsa002400.75375950
54Adherens junction_Homo sapiens_hsa045200.75067734
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73629298
56Purine metabolism_Homo sapiens_hsa002300.69361077
57Circadian rhythm_Homo sapiens_hsa047100.68440952
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67750898
59Phototransduction_Homo sapiens_hsa047440.64333551
60Colorectal cancer_Homo sapiens_hsa052100.63126875
61Fatty acid metabolism_Homo sapiens_hsa012120.61384817
62Lysine degradation_Homo sapiens_hsa003100.61343016
63Thyroid cancer_Homo sapiens_hsa052160.60283450
64Dopaminergic synapse_Homo sapiens_hsa047280.59327693
65Parkinsons disease_Homo sapiens_hsa050120.57432960
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57233706
67Arginine and proline metabolism_Homo sapiens_hsa003300.55757538
68beta-Alanine metabolism_Homo sapiens_hsa004100.55370274
69Tight junction_Homo sapiens_hsa045300.55266335
70Glutamatergic synapse_Homo sapiens_hsa047240.53529691
71Huntingtons disease_Homo sapiens_hsa050160.53504707
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51726333
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51718959
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50992192
75Alcoholism_Homo sapiens_hsa050340.48970119
76Peroxisome_Homo sapiens_hsa041460.48165722
77Axon guidance_Homo sapiens_hsa043600.46783098
78Folate biosynthesis_Homo sapiens_hsa007900.45912621
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45105774
80MicroRNAs in cancer_Homo sapiens_hsa052060.44978031
81Metabolic pathways_Homo sapiens_hsa011000.44514740
82Morphine addiction_Homo sapiens_hsa050320.42558820
83Long-term depression_Homo sapiens_hsa047300.39627697
84Oxidative phosphorylation_Homo sapiens_hsa001900.39268576
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38601311
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38433219
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38292079
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37977202
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37236776
90Serotonergic synapse_Homo sapiens_hsa047260.36152140
91Melanogenesis_Homo sapiens_hsa049160.30805319
92Circadian entrainment_Homo sapiens_hsa047130.30245437
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29759478
94Olfactory transduction_Homo sapiens_hsa047400.29487352
95Fatty acid biosynthesis_Homo sapiens_hsa000610.29012505
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28176619
97Fatty acid degradation_Homo sapiens_hsa000710.27285696
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.26356708
99Retinol metabolism_Homo sapiens_hsa008300.26254662
100Ether lipid metabolism_Homo sapiens_hsa005650.22775847

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »