ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	4.79565229
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.65345678
3	behavioral response to nicotine (GO:0035095)	4.42692219
4	protein complex biogenesis (GO:0070271)	4.32525828
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.27347832
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.25403563
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.25403563
8	NADH dehydrogenase complex assembly (GO:0010257)	4.25403563
9	mitochondrial respiratory chain complex assembly (GO:0033108)	4.14931210
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.12294656
11	ATP synthesis coupled proton transport (GO:0015986)	4.12294656
12	DNA replication checkpoint (GO:0000076)	4.08971704
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.04215027
14	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.96533020
15	termination of RNA polymerase III transcription (GO:0006386)	3.96533020
16	pseudouridine synthesis (GO:0001522)	3.94309215
17	regulation of mitochondrial translation (GO:0070129)	3.82816933
18	peptidyl-histidine modification (GO:0018202)	3.75982571
19	protein-cofactor linkage (GO:0018065)	3.70679618
20	base-excision repair, AP site formation (GO:0006285)	3.68535834
21	respiratory electron transport chain (GO:0022904)	3.62967109
22	electron transport chain (GO:0022900)	3.60311151
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.57782199
24	respiratory chain complex IV assembly (GO:0008535)	3.57226686
25	maturation of SSU-rRNA (GO:0030490)	3.52531301
26	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.31933838
27	rRNA modification (GO:0000154)	3.27978495
28	cytochrome complex assembly (GO:0017004)	3.27617261
29	ribosomal small subunit biogenesis (GO:0042274)	3.26892053
30	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.22578518
31	cullin deneddylation (GO:0010388)	3.22024503
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.19049805
33	intracellular protein transmembrane import (GO:0044743)	3.18713325
34	GTP biosynthetic process (GO:0006183)	3.15409188
35	proteasome assembly (GO:0043248)	3.07060503
36	chromatin remodeling at centromere (GO:0031055)	3.06011846
37	DNA strand renaturation (GO:0000733)	3.04298319
38	spliceosomal snRNP assembly (GO:0000387)	3.04253742
39	protein neddylation (GO:0045116)	3.03077088
40	establishment of protein localization to mitochondrion (GO:0072655)	2.99903856
41	protein deneddylation (GO:0000338)	2.98336508
42	protein targeting to mitochondrion (GO:0006626)	2.98077056
43	tRNA modification (GO:0006400)	2.93919068
44	cellular component biogenesis (GO:0044085)	2.93742265
45	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.93420373
46	replication fork processing (GO:0031297)	2.93402346
47	rRNA processing (GO:0006364)	2.91212463
48	preassembly of GPI anchor in ER membrane (GO:0016254)	2.87734190
49	tRNA processing (GO:0008033)	2.87643410
50	UTP biosynthetic process (GO:0006228)	2.87038225
51	iron-sulfur cluster assembly (GO:0016226)	2.85452879
52	metallo-sulfur cluster assembly (GO:0031163)	2.85452879
53	ribosomal small subunit assembly (GO:0000028)	2.85348941
54	CENP-A containing nucleosome assembly (GO:0034080)	2.85168694
55	rRNA metabolic process (GO:0016072)	2.81381500
56	DNA deamination (GO:0045006)	2.80412417
57	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.80014111
58	protein localization to mitochondrion (GO:0070585)	2.77515800
59	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.76654115
60	CTP metabolic process (GO:0046036)	2.71654349
61	CTP biosynthetic process (GO:0006241)	2.71654349
62	protein K6-linked ubiquitination (GO:0085020)	2.70102887
63	UTP metabolic process (GO:0046051)	2.66515136
64	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.65671635
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.64716193
66	L-serine metabolic process (GO:0006563)	2.64347357
67	meiotic chromosome segregation (GO:0045132)	2.64186960
68	intracellular protein transmembrane transport (GO:0065002)	2.63492508
69	rRNA methylation (GO:0031167)	2.62353797
70	ncRNA processing (GO:0034470)	2.56548190
71	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.55887373
72	DNA damage response, detection of DNA damage (GO:0042769)	2.55733823
73	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.53595034
74	ribonucleoprotein complex biogenesis (GO:0022613)	2.53291059
75	tRNA metabolic process (GO:0006399)	2.52306603
76	viral transcription (GO:0019083)	2.51815006
77	translational termination (GO:0006415)	2.51687336
78	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.51594327
79	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.51594327
80	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.51131823
81	ATP biosynthetic process (GO:0006754)	2.49965039
82	ncRNA metabolic process (GO:0034660)	2.48117268
83	protein transmembrane transport (GO:0071806)	2.47784646
84	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.46831477
85	serine family amino acid catabolic process (GO:0009071)	2.46069614
86	transcription-coupled nucleotide-excision repair (GO:0006283)	2.45196745
87	hydrogen ion transmembrane transport (GO:1902600)	2.45145448
88	guanosine-containing compound biosynthetic process (GO:1901070)	2.44768655
89	DNA replication-dependent nucleosome organization (GO:0034723)	2.42708990
90	DNA replication-dependent nucleosome assembly (GO:0006335)	2.42708990
91	ribosome biogenesis (GO:0042254)	2.41441293
92	mannosylation (GO:0097502)	2.41286267
93	nonmotile primary cilium assembly (GO:0035058)	2.41198944
94	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.40658464
95	kinetochore assembly (GO:0051382)	2.40354852
96	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.40232926
97	translation (GO:0006412)	2.38188079
98	DNA strand elongation involved in DNA replication (GO:0006271)	2.38005611
99	transcription from RNA polymerase I promoter (GO:0006360)	2.37047371
100	transcription from RNA polymerase III promoter (GO:0006383)	2.36352668

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.16376085
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.15247198
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.84226303
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.52745789
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.46717413
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.39514626
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.25104530
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.82366764
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.81720912
10	XRN2_22483619_ChIP-Seq_HELA_Human	2.68206758
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.63166180
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.61184336
13	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.54791789
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.33924537
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.29594156
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.26681372
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.23847970
18	GABP_19822575_ChIP-Seq_HepG2_Human	2.23293402
19	E2F7_22180533_ChIP-Seq_HELA_Human	2.16657495
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.09020008
21	VDR_23849224_ChIP-Seq_CD4+_Human	2.07465230
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.06367148
23	TTF2_22483619_ChIP-Seq_HELA_Human	2.03577794
24	ZNF274_21170338_ChIP-Seq_K562_Hela	2.01583536
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.99328768
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.98132962
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.97961638
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.95964988
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.91540745
30	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.91266659
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.85597701
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.85263717
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.84016039
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.77241141
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72099542
36	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.61613418
37	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.56297423
38	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.54778639
39	KDM5A_27292631_Chip-Seq_BREAST_Human	1.49671732
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49579378
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46769712
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.44737786
43	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.42943792
44	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.42413129
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40753645
46	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.40363332
47	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.38641909
48	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.37824900
49	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.35448432
50	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.35252609
51	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.29299032
52	EWS_26573619_Chip-Seq_HEK293_Human	1.25817738
53	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.25527331
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25188366
55	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.24644634
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20556301
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.20236373
58	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.19845227
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19337016
60	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.17979736
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16621147
62	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.13671138
63	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.13134588
64	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.12362653
65	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.12309788
66	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10678128
67	ERA_21632823_ChIP-Seq_H3396_Human	1.09369041
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.09160465
69	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08666586
70	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.03090909
71	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.02665255
72	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.01896536
73	P68_20966046_ChIP-Seq_HELA_Human	0.99724297
74	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.99694290
75	CIITA_25753668_ChIP-Seq_RAJI_Human	0.97444307
76	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96923976
77	VDR_22108803_ChIP-Seq_LS180_Human	0.95615530
78	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.95433222
79	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.95132028
80	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94817304
81	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.94703711
82	PHF8_20622854_ChIP-Seq_HELA_Human	0.94509308
83	E2F1_20622854_ChIP-Seq_HELA_Human	0.91926809
84	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.91404701
85	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.91355306
86	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.90696745
87	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.90653907
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90431820
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.89281047
90	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.89044016
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.88223648
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.87570559
93	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.87010634
94	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.86817026
95	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.86479539
96	* CTCF_27219007_Chip-Seq_Bcells_Human	0.86048912
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.85970096
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.85055966
99	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.83654519
100	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.82363065

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	4.26606610
2	MP0003136_yellow_coat_color	3.47269405
3	MP0002736_abnormal_nociception_after	2.63838460
4	MP0001968_abnormal_touch/_nociception	2.55273899
5	MP0001529_abnormal_vocalization	2.48180387
6	MP0005423_abnormal_somatic_nervous	2.43985117
7	MP0003693_abnormal_embryo_hatching	2.28755650
8	MP0002653_abnormal_ependyma_morphology	2.15940869
9	MP0008058_abnormal_DNA_repair	2.10086723
10	MP0010094_abnormal_chromosome_stability	2.06145157
11	MP0003880_abnormal_central_pattern	2.05730128
12	MP0001188_hyperpigmentation	2.00516483
13	MP0006292_abnormal_olfactory_placode	1.95626022
14	MP0001986_abnormal_taste_sensitivity	1.94232920
15	MP0005171_absent_coat_pigmentation	1.92606479
16	MP0002160_abnormal_reproductive_system	1.78054203
17	MP0008877_abnormal_DNA_methylation	1.76305185
18	MP0000049_abnormal_middle_ear	1.75549041
19	MP0006072_abnormal_retinal_apoptosis	1.73238005
20	MP0009745_abnormal_behavioral_response	1.72462661
21	MP0003111_abnormal_nucleus_morphology	1.68835715
22	MP0005551_abnormal_eye_electrophysiolog	1.57069003
23	MP0000631_abnormal_neuroendocrine_gland	1.56761042
24	MP0009379_abnormal_foot_pigmentation	1.53549963
25	MP0009046_muscle_twitch	1.47480679
26	MP0008789_abnormal_olfactory_epithelium	1.45824453
27	MP0001905_abnormal_dopamine_level	1.44394916
28	MP0002249_abnormal_larynx_morphology	1.42758904
29	MP0002735_abnormal_chemical_nociception	1.41049301
30	MP0004859_abnormal_synaptic_plasticity	1.37504240
31	MP0004147_increased_porphyrin_level	1.34697431
32	MP0004133_heterotaxia	1.34644933
33	MP0006036_abnormal_mitochondrial_physio	1.34486026
34	MP0003786_premature_aging	1.34319322
35	MP0002064_seizures	1.34032014
36	MP0005174_abnormal_tail_pigmentation	1.32876226
37	MP0003635_abnormal_synaptic_transmissio	1.31205338
38	MP0008932_abnormal_embryonic_tissue	1.31175248
39	MP0002638_abnormal_pupillary_reflex	1.30606202
40	MP0004885_abnormal_endolymph	1.29784914
41	MP0002272_abnormal_nervous_system	1.28780391
42	MP0004142_abnormal_muscle_tone	1.28497521
43	MP0003718_maternal_effect	1.26676094
44	MP0005646_abnormal_pituitary_gland	1.25134811
45	MP0005499_abnormal_olfactory_system	1.20382413
46	MP0005394_taste/olfaction_phenotype	1.20382413
47	MP0008875_abnormal_xenobiotic_pharmacok	1.19943441
48	MP0002751_abnormal_autonomic_nervous	1.19714838
49	MP0002938_white_spotting	1.18236832
50	MP0003077_abnormal_cell_cycle	1.17934975
51	MP0006276_abnormal_autonomic_nervous	1.16814195
52	MP0003937_abnormal_limbs/digits/tail_de	1.13916706
53	MP0005253_abnormal_eye_physiology	1.12943250
54	MP0006035_abnormal_mitochondrial_morpho	1.12826719
55	MP0001970_abnormal_pain_threshold	1.12507627
56	MP0002063_abnormal_learning/memory/cond	1.12014708
57	MP0002572_abnormal_emotion/affect_behav	1.11925997
58	MP0002102_abnormal_ear_morphology	1.09952017
59	MP0000778_abnormal_nervous_system	1.09166719
60	MP0008872_abnormal_physiological_respon	1.09163825
61	MP0003123_paternal_imprinting	1.07272044
62	MP0005389_reproductive_system_phenotype	1.06558831
63	MP0008007_abnormal_cellular_replicative	1.06101929
64	MP0004957_abnormal_blastocyst_morpholog	1.05152144
65	MP0001486_abnormal_startle_reflex	1.04550356
66	MP0003011_delayed_dark_adaptation	1.01707797
67	MP0001293_anophthalmia	0.99731753
68	MP0001502_abnormal_circadian_rhythm	0.98884164
69	MP0002234_abnormal_pharynx_morphology	0.98645206
70	MP0001984_abnormal_olfaction	0.97292278
71	MP0010030_abnormal_orbit_morphology	0.96447508
72	MP0000026_abnormal_inner_ear	0.96383629
73	MP0002277_abnormal_respiratory_mucosa	0.96178670
74	MP0003283_abnormal_digestive_organ	0.95679488
75	MP0000955_abnormal_spinal_cord	0.95198651
76	MP0003119_abnormal_digestive_system	0.94362987
77	MP0005386_behavior/neurological_phenoty	0.93519011
78	MP0004924_abnormal_behavior	0.93519011
79	MP0003938_abnormal_ear_development	0.93407186
80	MP0002282_abnormal_trachea_morphology	0.93110216
81	MP0002733_abnormal_thermal_nociception	0.92556048
82	MP0002557_abnormal_social/conspecific_i	0.92118497
83	MP0003137_abnormal_impulse_conducting	0.91974017
84	MP0002184_abnormal_innervation	0.89045799
85	MP0002210_abnormal_sex_determination	0.87463785
86	MP0009250_abnormal_appendicular_skeleto	0.87244587
87	MP0004043_abnormal_pH_regulation	0.86961989
88	MP0002752_abnormal_somatic_nervous	0.86649278
89	MP0005084_abnormal_gallbladder_morpholo	0.84749429
90	MP0001919_abnormal_reproductive_system	0.84392234
91	MP0004742_abnormal_vestibular_system	0.84089377
92	MP0004145_abnormal_muscle_electrophysio	0.84005092
93	MP0001764_abnormal_homeostasis	0.83505025
94	MP0002067_abnormal_sensory_capabilities	0.83342436
95	MP0001346_abnormal_lacrimal_gland	0.83276453
96	MP0003186_abnormal_redox_activity	0.82544858
97	MP0002876_abnormal_thyroid_physiology	0.82487705
98	MP0002734_abnormal_mechanical_nocicepti	0.82038447
99	MP0003121_genomic_imprinting	0.81460728
100	MP0002837_dystrophic_cardiac_calcinosis	0.79956501

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.07231567
2	Mitochondrial inheritance (HP:0001427)	3.93074190
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.82281678
4	Increased hepatocellular lipid droplets (HP:0006565)	3.69703966
5	Increased CSF lactate (HP:0002490)	3.60638692
6	Acute encephalopathy (HP:0006846)	3.59173834
7	Lipid accumulation in hepatocytes (HP:0006561)	3.55378725
8	Renal Fanconi syndrome (HP:0001994)	3.45276464
9	Hepatocellular necrosis (HP:0001404)	3.42059740
10	Progressive macrocephaly (HP:0004481)	3.22392914
11	Testicular atrophy (HP:0000029)	3.15084675
12	Hepatic necrosis (HP:0002605)	3.10398230
13	Birth length less than 3rd percentile (HP:0003561)	3.09760008
14	Abnormal number of erythroid precursors (HP:0012131)	3.07130669
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.92192517
16	Congenital stationary night blindness (HP:0007642)	2.91068430
17	Increased intramyocellular lipid droplets (HP:0012240)	2.90690815
18	Rib fusion (HP:0000902)	2.90271801
19	Pancreatic cysts (HP:0001737)	2.74446677
20	Abnormality of cells of the erythroid lineage (HP:0012130)	2.70804444
21	Abnormality of alanine metabolism (HP:0010916)	2.68732425
22	Hyperalaninemia (HP:0003348)	2.68732425
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.68732425
24	Patellar aplasia (HP:0006443)	2.68669460
25	Aplasia/Hypoplasia of the patella (HP:0006498)	2.66479324
26	Pendular nystagmus (HP:0012043)	2.64005117
27	Increased serum lactate (HP:0002151)	2.63904074
28	True hermaphroditism (HP:0010459)	2.62505883
29	Abnormality of midbrain morphology (HP:0002418)	2.59503648
30	Molar tooth sign on MRI (HP:0002419)	2.59503648
31	Pancreatic fibrosis (HP:0100732)	2.57305632
32	Increased muscle lipid content (HP:0009058)	2.52589170
33	Optic disc pallor (HP:0000543)	2.51026743
34	Lactic acidosis (HP:0003128)	2.47041425
35	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.43919590
36	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.43919590
37	Methylmalonic aciduria (HP:0012120)	2.38788927
38	Rectal fistula (HP:0100590)	2.35701683
39	Rectovaginal fistula (HP:0000143)	2.35701683
40	Colon cancer (HP:0003003)	2.34376395
41	Myokymia (HP:0002411)	2.31572760
42	Cerebral edema (HP:0002181)	2.31072884
43	Reticulocytopenia (HP:0001896)	2.26680489
44	Sclerocornea (HP:0000647)	2.21801450
45	Type II lissencephaly (HP:0007260)	2.20568350
46	3-Methylglutaconic aciduria (HP:0003535)	2.19943300
47	Absent thumb (HP:0009777)	2.19749692
48	Exertional dyspnea (HP:0002875)	2.19469408
49	Hypoplasia of the pons (HP:0012110)	2.18097431
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.15329276
51	Medial flaring of the eyebrow (HP:0010747)	2.13823192
52	Nephronophthisis (HP:0000090)	2.13253465
53	Abnormality of renal resorption (HP:0011038)	2.11186018
54	Progressive microcephaly (HP:0000253)	2.08393718
55	Exercise intolerance (HP:0003546)	2.08315130
56	Respiratory difficulties (HP:0002880)	2.07532199
57	Anencephaly (HP:0002323)	2.07062972
58	Abnormality of the pons (HP:0007361)	2.04640512
59	Gait imbalance (HP:0002141)	2.04129339
60	Respiratory failure (HP:0002878)	2.02400870
61	Concave nail (HP:0001598)	2.02311107
62	Microretrognathia (HP:0000308)	2.00386872
63	Glycosuria (HP:0003076)	2.00208524
64	Abnormality of urine glucose concentration (HP:0011016)	2.00208524
65	Attenuation of retinal blood vessels (HP:0007843)	2.00029019
66	Leukodystrophy (HP:0002415)	1.97642726
67	Vaginal fistula (HP:0004320)	1.94892316
68	Methylmalonic acidemia (HP:0002912)	1.91128445
69	Severe muscular hypotonia (HP:0006829)	1.86148321
70	Intestinal fistula (HP:0100819)	1.85420297
71	Cerebral hypomyelination (HP:0006808)	1.83193449
72	Congenital primary aphakia (HP:0007707)	1.82969080
73	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.82716403
74	Abnormal drinking behavior (HP:0030082)	1.82517253
75	Polydipsia (HP:0001959)	1.82517253
76	Broad distal phalanx of finger (HP:0009836)	1.78688932
77	Chorioretinal atrophy (HP:0000533)	1.74950378
78	Macrocytic anemia (HP:0001972)	1.74887813
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74023067
80	Dyschromatopsia (HP:0007641)	1.73755351
81	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.72802903
82	Opisthotonus (HP:0002179)	1.71215942
83	Occipital encephalocele (HP:0002085)	1.70154857
84	Absent radius (HP:0003974)	1.68843872
85	Meckel diverticulum (HP:0002245)	1.68273279
86	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.67548792
87	Hypoplasia of the radius (HP:0002984)	1.66831955
88	Polyuria (HP:0000103)	1.66635351
89	Breast hypoplasia (HP:0003187)	1.66597613
90	Congenital, generalized hypertrichosis (HP:0004540)	1.66096793
91	Triphalangeal thumb (HP:0001199)	1.65812671
92	Horseshoe kidney (HP:0000085)	1.65577654
93	Abnormality of the ileum (HP:0001549)	1.65069869
94	Absent forearm bone (HP:0003953)	1.65037687
95	Aplasia involving forearm bones (HP:0009822)	1.65037687
96	Lethargy (HP:0001254)	1.64996436
97	Retinal dysplasia (HP:0007973)	1.63461232
98	Short thumb (HP:0009778)	1.61487174
99	Preaxial hand polydactyly (HP:0001177)	1.61230247
100	Abnormality of the renal medulla (HP:0100957)	1.60414297

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.52686765
2	STK16	3.62523270
3	ZAK	3.34102724
4	VRK2	3.21129900
5	BUB1	3.07925214
6	VRK1	2.45888812
7	MAPK15	2.42106835
8	NME1	2.27428314
9	MAP4K2	2.11943002
10	WNK4	2.08610231
11	CDC7	1.94348519
12	ADRBK2	1.92108826
13	GRK1	1.89425389
14	DYRK2	1.78200758
15	SRPK1	1.67060623
16	NUAK1	1.67055259
17	MAP2K7	1.63356635
18	BCKDK	1.59125303
19	PINK1	1.54389065
20	MUSK	1.52582432
21	BMPR1B	1.52025021
22	NME2	1.51972201
23	WNK3	1.44724149
24	MAPK13	1.42286008
25	CSNK1G3	1.40796719
26	MARK1	1.40379958
27	MAP3K4	1.39025718
28	TAF1	1.33198189
29	FRK	1.32362973
30	WEE1	1.28359120
31	CSNK1G1	1.25446112
32	PDK2	1.24116637
33	CHEK2	1.23090419
34	CSNK1A1L	1.21426185
35	PHKG1	1.20502107
36	PHKG2	1.20502107
37	CSNK1G2	1.17271718
38	ATR	1.09170126
39	PLK3	1.09004426
40	AURKA	1.08545233
41	PLK1	1.06079638
42	CASK	1.05431014
43	CCNB1	1.04503576
44	CDK8	1.04418908
45	PRKCG	0.99326906
46	DYRK3	0.97950491
47	PLK4	0.89335632
48	PNCK	0.87734079
49	TRIM28	0.87656227
50	NTRK2	0.85181700
51	RPS6KA5	0.83296648
52	INSRR	0.82910096
53	TSSK6	0.79780627
54	LIMK1	0.77703739
55	PIM2	0.77411220
56	EPHA4	0.73336503
57	MINK1	0.72487438
58	PKN1	0.70417305
59	PRKCI	0.70133652
60	PAK6	0.68959906
61	OXSR1	0.68865158
62	PBK	0.67837291
63	NEK1	0.67345803
64	TNIK	0.67117306
65	PRKD3	0.66002464
66	ABL2	0.64762246
67	IRAK2	0.62587014
68	MAPKAPK5	0.62324266
69	ADRBK1	0.61436059
70	UHMK1	0.58900440
71	AURKB	0.58314544
72	TESK2	0.58006432
73	TAOK3	0.56631860
74	PLK2	0.53799773
75	BRSK1	0.53556246
76	NEK2	0.50580653
77	NTRK3	0.49486755
78	MAP2K4	0.49301904
79	TIE1	0.48442608
80	CSNK1A1	0.48301881
81	TTK	0.48147594
82	CSNK2A1	0.47719556
83	BCR	0.46918857
84	ATM	0.46373644
85	DAPK2	0.45913969
86	DAPK1	0.45790565
87	EIF2AK2	0.44067612
88	CDK11A	0.42619559
89	CDK15	0.42409633
90	CDK18	0.40181695
91	CSNK1E	0.39781851
92	CDK14	0.39382814
93	CSNK2A2	0.39359741
94	CDK3	0.38606099
95	DAPK3	0.38552745
96	GRK5	0.37525933
97	CSNK1D	0.37204178
98	STK39	0.37003171
99	AKT2	0.36294222
100	CAMK1	0.35113417

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.58446115
2	RNA polymerase_Homo sapiens_hsa03020	3.26475594
3	Ribosome_Homo sapiens_hsa03010	3.13648702
4	Parkinsons disease_Homo sapiens_hsa05012	3.09685103
5	Homologous recombination_Homo sapiens_hsa03440	2.83321676
6	Sulfur relay system_Homo sapiens_hsa04122	2.82648795
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.68586214
8	DNA replication_Homo sapiens_hsa03030	2.55483910
9	Proteasome_Homo sapiens_hsa03050	2.31807742
10	Huntingtons disease_Homo sapiens_hsa05016	2.30524277
11	Base excision repair_Homo sapiens_hsa03410	2.27224825
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.09916422
13	Alzheimers disease_Homo sapiens_hsa05010	2.06061150
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03209372
15	Pyrimidine metabolism_Homo sapiens_hsa00240	2.02990138
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.98507859
17	Basal transcription factors_Homo sapiens_hsa03022	1.95909561
18	Mismatch repair_Homo sapiens_hsa03430	1.90528088
19	One carbon pool by folate_Homo sapiens_hsa00670	1.81656637
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.81364860
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.77225935
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.74964841
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71050523
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.66508238
25	Protein export_Homo sapiens_hsa03060	1.64662311
26	Nicotine addiction_Homo sapiens_hsa05033	1.59633271
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.49481642
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.46973068
29	Spliceosome_Homo sapiens_hsa03040	1.44351262
30	RNA degradation_Homo sapiens_hsa03018	1.33383794
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.29581325
32	Purine metabolism_Homo sapiens_hsa00230	1.27441460
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27396360
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.26255835
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.23346813
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14444685
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.13415219
38	RNA transport_Homo sapiens_hsa03013	1.12752721
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.08657962
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07833385
41	Phototransduction_Homo sapiens_hsa04744	1.07222028
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05107520
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04555279
44	Butanoate metabolism_Homo sapiens_hsa00650	0.94203713
45	Propanoate metabolism_Homo sapiens_hsa00640	0.93401463
46	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88133768
47	Metabolic pathways_Homo sapiens_hsa01100	0.84980599
48	Cell cycle_Homo sapiens_hsa04110	0.84496074
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81567849
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74763411
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.73463598
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72176176
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.69661897
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67804126
55	Peroxisome_Homo sapiens_hsa04146	0.67100438
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.65504795
57	Alcoholism_Homo sapiens_hsa05034	0.64805104
58	Morphine addiction_Homo sapiens_hsa05032	0.62052828
59	Taste transduction_Homo sapiens_hsa04742	0.61791816
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61762558
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60830563
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.59898368
63	Fatty acid elongation_Homo sapiens_hsa00062	0.59892623
64	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.57369147
65	GABAergic synapse_Homo sapiens_hsa04727	0.56930056
66	Folate biosynthesis_Homo sapiens_hsa00790	0.55888309
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.55801904
68	Linoleic acid metabolism_Homo sapiens_hsa00591	0.54319495
69	Basal cell carcinoma_Homo sapiens_hsa05217	0.53053847
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50261231
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.49208287
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47028718
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45775810
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44949220
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43619787
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41224858
77	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.40944987
78	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39536905
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39153178
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38780197
81	Cocaine addiction_Homo sapiens_hsa05030	0.33546157
82	Sulfur metabolism_Homo sapiens_hsa00920	0.33112554
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.31598526
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.30697999
85	Olfactory transduction_Homo sapiens_hsa04740	0.30318404
86	mRNA surveillance pathway_Homo sapiens_hsa03015	0.30274895
87	Insulin secretion_Homo sapiens_hsa04911	0.30047458
88	Lysine degradation_Homo sapiens_hsa00310	0.29940048
89	Fatty acid degradation_Homo sapiens_hsa00071	0.29464664
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29301254
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.29067214
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.28520284
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27318122
94	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.27075800
95	Circadian entrainment_Homo sapiens_hsa04713	0.27030922
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26937333
97	Oocyte meiosis_Homo sapiens_hsa04114	0.26578969
98	Cholinergic synapse_Homo sapiens_hsa04725	0.24788197
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.24181694
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.24164582

ZNF771

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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