ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.65707274
2	response to pheromone (GO:0019236)	4.62735727
3	L-fucose catabolic process (GO:0042355)	4.35816626
4	fucose catabolic process (GO:0019317)	4.35816626
5	L-fucose metabolic process (GO:0042354)	4.35816626
6	tryptophan catabolic process (GO:0006569)	4.04304165
7	indole-containing compound catabolic process (GO:0042436)	4.04304165
8	indolalkylamine catabolic process (GO:0046218)	4.04304165
9	indolalkylamine metabolic process (GO:0006586)	4.04085061
10	kynurenine metabolic process (GO:0070189)	3.91567214
11	tryptophan metabolic process (GO:0006568)	3.84570968
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.66978805
13	DNA deamination (GO:0045006)	3.62157779
14	epithelial cilium movement (GO:0003351)	3.45651739
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.44123673
16	detection of light stimulus involved in visual perception (GO:0050908)	3.44123673
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.43100153
18	cellular ketone body metabolic process (GO:0046950)	3.24879015
19	NADH dehydrogenase complex assembly (GO:0010257)	3.21008976
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.21008976
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.21008976
22	indole-containing compound metabolic process (GO:0042430)	3.19666073
23	protein polyglutamylation (GO:0018095)	3.14464663
24	neural tube formation (GO:0001841)	3.12957936
25	gamma-aminobutyric acid transport (GO:0015812)	3.12438441
26	piRNA metabolic process (GO:0034587)	3.11935533
27	protein complex biogenesis (GO:0070271)	3.10736513
28	primary amino compound metabolic process (GO:1901160)	3.10685251
29	negative regulation of mast cell activation (GO:0033004)	3.09072239
30	cornea development in camera-type eye (GO:0061303)	3.08351622
31	nephron epithelium morphogenesis (GO:0072088)	3.02908047
32	nephron tubule morphogenesis (GO:0072078)	3.02908047
33	negative regulation of telomere maintenance (GO:0032205)	2.99430292
34	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.99122505
35	behavioral response to ethanol (GO:0048149)	2.98175090
36	sulfation (GO:0051923)	2.97222662
37	kidney morphogenesis (GO:0060993)	2.96965783
38	water-soluble vitamin biosynthetic process (GO:0042364)	2.94255461
39	platelet dense granule organization (GO:0060155)	2.90303310
40	ketone body metabolic process (GO:1902224)	2.89703884
41	preassembly of GPI anchor in ER membrane (GO:0016254)	2.87508686
42	cilium movement (GO:0003341)	2.87478814
43	neuronal action potential (GO:0019228)	2.85772444
44	serotonin metabolic process (GO:0042428)	2.84785216
45	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83494396
46	axoneme assembly (GO:0035082)	2.82442038
47	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.82242785
48	protein K11-linked deubiquitination (GO:0035871)	2.81437467
49	regulation of cilium movement (GO:0003352)	2.77792362
50	cellular biogenic amine catabolic process (GO:0042402)	2.77779630
51	amine catabolic process (GO:0009310)	2.77779630
52	somite development (GO:0061053)	2.75476348
53	respiratory chain complex IV assembly (GO:0008535)	2.73691442
54	dopamine transport (GO:0015872)	2.72875544
55	regulation of neurotransmitter uptake (GO:0051580)	2.71165239
56	DNA methylation involved in gamete generation (GO:0043046)	2.70818226
57	nonmotile primary cilium assembly (GO:0035058)	2.70640879
58	multicellular organism reproduction (GO:0032504)	2.69415492
59	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.67955007
60	pyrimidine nucleobase catabolic process (GO:0006208)	2.66711384
61	glycerophospholipid catabolic process (GO:0046475)	2.66440985
62	regulation of action potential (GO:0098900)	2.65820958
63	cilium morphogenesis (GO:0060271)	2.64804377
64	rhodopsin mediated signaling pathway (GO:0016056)	2.63810857
65	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.63579405
66	cAMP catabolic process (GO:0006198)	2.63446190
67	cilium or flagellum-dependent cell motility (GO:0001539)	2.62398884
68	peristalsis (GO:0030432)	2.61094318
69	synaptic transmission, cholinergic (GO:0007271)	2.60010597
70	transmission of nerve impulse (GO:0019226)	2.58704000
71	reflex (GO:0060004)	2.57715648
72	protein localization to cilium (GO:0061512)	2.57600511
73	oxidative demethylation (GO:0070989)	2.57517460
74	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.56942532
75	regulation of hippo signaling (GO:0035330)	2.55980375
76	cilium organization (GO:0044782)	2.55716927
77	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.55123129
78	spinal cord motor neuron differentiation (GO:0021522)	2.54596168
79	DNA demethylation (GO:0080111)	2.51535028
80	photoreceptor cell maintenance (GO:0045494)	2.50791419
81	adaptation of signaling pathway (GO:0023058)	2.50027076
82	retinal cone cell development (GO:0046549)	2.48796873
83	sperm motility (GO:0030317)	2.48561762
84	negative regulation of systemic arterial blood pressure (GO:0003085)	2.48499927
85	auditory receptor cell stereocilium organization (GO:0060088)	2.48108885
86	cilium assembly (GO:0042384)	2.46089290
87	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.44857703
88	positive regulation of fatty acid transport (GO:2000193)	2.44639975
89	cytochrome complex assembly (GO:0017004)	2.43327943
90	renal tubule morphogenesis (GO:0061333)	2.43119832
91	cyclic nucleotide catabolic process (GO:0009214)	2.41320176
92	nucleobase catabolic process (GO:0046113)	2.41160277
93	NAD biosynthetic process (GO:0009435)	2.41000396
94	phasic smooth muscle contraction (GO:0014821)	2.40726824
95	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.40163988
96	neuronal action potential propagation (GO:0019227)	2.39908806
97	intraciliary transport (GO:0042073)	2.39347201
98	regulation of hexokinase activity (GO:1903299)	2.37592273
99	regulation of glucokinase activity (GO:0033131)	2.37592273
100	mannosylation (GO:0097502)	2.36399723

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.97889663
2	VDR_22108803_ChIP-Seq_LS180_Human	3.08419039
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.08208090
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.93244301
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88850989
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.79166488
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71114465
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48142923
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41952670
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29772999
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.21285186
12	FUS_26573619_Chip-Seq_HEK293_Human	2.11281964
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03592391
14	EWS_26573619_Chip-Seq_HEK293_Human	1.99692416
15	P300_19829295_ChIP-Seq_ESCs_Human	1.96735465
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.93191181
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93086241
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.87040621
19	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78992183
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78111442
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64347247
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.62407729
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.59797318
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59747815
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.58552404
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58274621
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57681293
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54391475
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53289066
30	STAT3_23295773_ChIP-Seq_U87_Human	1.52847732
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.52834148
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.52694166
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52694166
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52213992
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51382304
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50309293
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49751439
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.49504521
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48995886
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48995886
41	AR_25329375_ChIP-Seq_VCAP_Human	1.47520738
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43523766
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43221906
44	TCF4_23295773_ChIP-Seq_U87_Human	1.39900385
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38766339
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37652654
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37066589
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35240461
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34970005
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34970005
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33152787
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32189437
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30849645
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28812854
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28812854
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28733854
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28334145
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27360079
59	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.26684369
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.25544058
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.23622947
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23041212
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23027699
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21787317
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19817331
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19258908
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18999388
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18414948
69	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.17856636
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17792930
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17134365
72	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17112387
73	NCOR_22424771_ChIP-Seq_293T_Human	1.17023442
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.17014935
75	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16079231
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14690501
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14668269
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13917925
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12523353
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10196749
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09668206
82	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.07499428
83	AR_20517297_ChIP-Seq_VCAP_Human	1.06772835
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05400991
85	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.05326713
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05081489
87	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02677097
88	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01824430
89	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.00556907
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99417789
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99395053
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98889815
93	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98159206
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97122265
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.96606950
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96579564
97	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96474802
98	DROSHA_22980978_ChIP-Seq_HELA_Human	0.95652434
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94916335
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94691545

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.06400098
2	MP0003646_muscle_fatigue	2.88148418
3	MP0008877_abnormal_DNA_methylation	2.51362160
4	MP0005551_abnormal_eye_electrophysiolog	2.44056331
5	MP0002102_abnormal_ear_morphology	2.27876709
6	MP0001968_abnormal_touch/_nociception	2.27263072
7	MP0003136_yellow_coat_color	2.22401516
8	MP0008872_abnormal_physiological_respon	2.19638299
9	MP0005646_abnormal_pituitary_gland	2.15784359
10	MP0009046_muscle_twitch	2.02254872
11	MP0002837_dystrophic_cardiac_calcinosis	1.98251705
12	MP0009745_abnormal_behavioral_response	1.97396759
13	MP0006292_abnormal_olfactory_placode	1.96815621
14	MP0004043_abnormal_pH_regulation	1.96394266
15	MP0005645_abnormal_hypothalamus_physiol	1.91149945
16	MP0002736_abnormal_nociception_after	1.87031064
17	MP0000372_irregular_coat_pigmentation	1.84788833
18	MP0000569_abnormal_digit_pigmentation	1.84064437
19	MP0003787_abnormal_imprinting	1.81322091
20	MP0001501_abnormal_sleep_pattern	1.78188384
21	MP0005253_abnormal_eye_physiology	1.77491892
22	MP0002272_abnormal_nervous_system	1.76318053
23	MP0006072_abnormal_retinal_apoptosis	1.76066014
24	MP0008875_abnormal_xenobiotic_pharmacok	1.74731816
25	MP0001986_abnormal_taste_sensitivity	1.74540272
26	MP0004142_abnormal_muscle_tone	1.74140406
27	MP0004885_abnormal_endolymph	1.73002718
28	MP0002876_abnormal_thyroid_physiology	1.72347755
29	MP0002638_abnormal_pupillary_reflex	1.71071508
30	MP0002735_abnormal_chemical_nociception	1.70374844
31	MP0001485_abnormal_pinna_reflex	1.70018587
32	MP0004147_increased_porphyrin_level	1.68021806
33	MP0003880_abnormal_central_pattern	1.59154969
34	MP0006276_abnormal_autonomic_nervous	1.55295920
35	MP0000631_abnormal_neuroendocrine_gland	1.54740220
36	MP0002653_abnormal_ependyma_morphology	1.51760909
37	MP0002938_white_spotting	1.50169263
38	MP0001486_abnormal_startle_reflex	1.49596604
39	MP0005084_abnormal_gallbladder_morpholo	1.49527844
40	MP0005410_abnormal_fertilization	1.45911324
41	MP0004145_abnormal_muscle_electrophysio	1.45310777
42	MP0001529_abnormal_vocalization	1.42155289
43	MP0000427_abnormal_hair_cycle	1.41063995
44	MP0002064_seizures	1.38613799
45	MP0002572_abnormal_emotion/affect_behav	1.36864608
46	MP0002928_abnormal_bile_duct	1.36301248
47	MP0004742_abnormal_vestibular_system	1.35828259
48	MP0003011_delayed_dark_adaptation	1.31336702
49	MP0002557_abnormal_social/conspecific_i	1.31251512
50	MP0001970_abnormal_pain_threshold	1.28094473
51	MP0002822_catalepsy	1.28007257
52	MP0004133_heterotaxia	1.27032553
53	MP0002733_abnormal_thermal_nociception	1.26593857
54	MP0002234_abnormal_pharynx_morphology	1.25943388
55	MP0003283_abnormal_digestive_organ	1.25352589
56	MP0000383_abnormal_hair_follicle	1.23532975
57	MP0004924_abnormal_behavior	1.22291133
58	MP0005386_behavior/neurological_phenoty	1.22291133
59	MP0001984_abnormal_olfaction	1.18363308
60	MP0002067_abnormal_sensory_capabilities	1.18131333
61	MP0010386_abnormal_urinary_bladder	1.18047410
62	MP0005167_abnormal_blood-brain_barrier	1.17059136
63	MP0001905_abnormal_dopamine_level	1.14227161
64	MP0003635_abnormal_synaptic_transmissio	1.12573223
65	MP0005377_hearing/vestibular/ear_phenot	1.10847421
66	MP0003878_abnormal_ear_physiology	1.10847421
67	MP0002063_abnormal_learning/memory/cond	1.10132195
68	MP0005174_abnormal_tail_pigmentation	1.05302015
69	MP0003718_maternal_effect	1.05188019
70	MP0004215_abnormal_myocardial_fiber	1.03435786
71	MP0005171_absent_coat_pigmentation	0.99812922
72	MP0002138_abnormal_hepatobiliary_system	0.99488028
73	MP0005389_reproductive_system_phenotype	0.99189688
74	MP0000026_abnormal_inner_ear	0.99049534
75	MP0003137_abnormal_impulse_conducting	0.98879144
76	MP0005083_abnormal_biliary_tract	0.96603436
77	MP0000230_abnormal_systemic_arterial	0.96521994
78	MP0003698_abnormal_male_reproductive	0.95285234
79	MP0005195_abnormal_posterior_eye	0.94275748
80	MP0002734_abnormal_mechanical_nocicepti	0.93951167
81	MP0005085_abnormal_gallbladder_physiolo	0.93224067
82	MP0008775_abnormal_heart_ventricle	0.92362522
83	MP0003252_abnormal_bile_duct	0.92190731
84	MP0002184_abnormal_innervation	0.91464736
85	MP0008995_early_reproductive_senescence	0.89413637
86	MP0002277_abnormal_respiratory_mucosa	0.88169517
87	MP0002160_abnormal_reproductive_system	0.88005028
88	MP0002752_abnormal_somatic_nervous	0.86599220
89	MP0001963_abnormal_hearing_physiology	0.86340354
90	MP0002163_abnormal_gland_morphology	0.84781643
91	MP0001919_abnormal_reproductive_system	0.84697608
92	MP0005379_endocrine/exocrine_gland_phen	0.84074217
93	MP0002229_neurodegeneration	0.83348396
94	MP0004085_abnormal_heartbeat	0.83004348
95	MP0005670_abnormal_white_adipose	0.82492652
96	MP0001929_abnormal_gametogenesis	0.81568181
97	MP0005332_abnormal_amino_acid	0.80505158
98	MP0002751_abnormal_autonomic_nervous	0.80112822
99	MP0001502_abnormal_circadian_rhythm	0.78099513
100	MP0003119_abnormal_digestive_system	0.77965354

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.34540618
2	Abnormality of midbrain morphology (HP:0002418)	4.10559029
3	Molar tooth sign on MRI (HP:0002419)	4.10559029
4	Congenital stationary night blindness (HP:0007642)	4.01885850
5	Pancreatic fibrosis (HP:0100732)	3.90287832
6	True hermaphroditism (HP:0010459)	3.86394536
7	Nephronophthisis (HP:0000090)	3.76381479
8	Type II lissencephaly (HP:0007260)	3.37142854
9	Abnormality of the renal cortex (HP:0011035)	3.36736176
10	Abnormality of the renal medulla (HP:0100957)	3.32726895
11	Attenuation of retinal blood vessels (HP:0007843)	3.25264108
12	Hyperventilation (HP:0002883)	3.13307407
13	Medial flaring of the eyebrow (HP:0010747)	3.08176209
14	Tubular atrophy (HP:0000092)	2.92688979
15	Inability to walk (HP:0002540)	2.86369117
16	Chronic hepatic failure (HP:0100626)	2.75626823
17	Abolished electroretinogram (ERG) (HP:0000550)	2.73429520
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.72946106
19	Cystic liver disease (HP:0006706)	2.70844145
20	Polydipsia (HP:0001959)	2.67059124
21	Abnormal drinking behavior (HP:0030082)	2.67059124
22	Pendular nystagmus (HP:0012043)	2.63559285
23	Large for gestational age (HP:0001520)	2.56452376
24	Gaze-evoked nystagmus (HP:0000640)	2.51963132
25	Progressive inability to walk (HP:0002505)	2.51821046
26	Cerebellar dysplasia (HP:0007033)	2.50429206
27	Progressive cerebellar ataxia (HP:0002073)	2.48732769
28	Abnormality of alanine metabolism (HP:0010916)	2.45828450
29	Hyperalaninemia (HP:0003348)	2.45828450
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.45828450
31	Absent/shortened dynein arms (HP:0200106)	2.41363285
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.41363285
33	Gait imbalance (HP:0002141)	2.39722052
34	Lissencephaly (HP:0001339)	2.39456989
35	Sclerocornea (HP:0000647)	2.39018463
36	Genetic anticipation (HP:0003743)	2.39001910
37	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.38541975
38	3-Methylglutaconic aciduria (HP:0003535)	2.33112926
39	Abnormality of the pons (HP:0007361)	2.32883953
40	Congenital primary aphakia (HP:0007707)	2.32613344
41	Renal cortical cysts (HP:0000803)	2.27936879
42	Increased corneal curvature (HP:0100692)	2.26902654
43	Keratoconus (HP:0000563)	2.26902654
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.26805775
45	Bony spicule pigmentary retinopathy (HP:0007737)	2.26033458
46	Chorioretinal atrophy (HP:0000533)	2.25373059
47	Birth length less than 3rd percentile (HP:0003561)	2.24483729
48	Decreased central vision (HP:0007663)	2.22850222
49	Hypothermia (HP:0002045)	2.21161001
50	Patellar aplasia (HP:0006443)	2.18000709
51	Hypoplasia of the pons (HP:0012110)	2.17390363
52	Protruding tongue (HP:0010808)	2.13635842
53	Broad-based gait (HP:0002136)	2.13341189
54	Congenital hepatic fibrosis (HP:0002612)	2.12859028
55	Nephrogenic diabetes insipidus (HP:0009806)	2.11698467
56	Aplasia/Hypoplasia of the patella (HP:0006498)	2.11639439
57	Congenital sensorineural hearing impairment (HP:0008527)	2.11578142
58	Polyuria (HP:0000103)	2.09856958
59	Febrile seizures (HP:0002373)	2.08178071
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05453383
61	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02834854
62	Abnormal respiratory epithelium morphology (HP:0012253)	2.02834854
63	Abnormal ciliary motility (HP:0012262)	2.01456799
64	Furrowed tongue (HP:0000221)	2.01415741
65	Pachygyria (HP:0001302)	2.01169187
66	Hemiparesis (HP:0001269)	2.00880996
67	Anencephaly (HP:0002323)	2.00571553
68	Methylmalonic acidemia (HP:0002912)	1.99333086
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99106293
70	Increased CSF lactate (HP:0002490)	1.98575609
71	Bile duct proliferation (HP:0001408)	1.98100654
72	Abnormal biliary tract physiology (HP:0012439)	1.98100654
73	Decreased circulating renin level (HP:0003351)	1.96958171
74	Genital tract atresia (HP:0001827)	1.96719804
75	Mitochondrial inheritance (HP:0001427)	1.96594207
76	Male pseudohermaphroditism (HP:0000037)	1.93806558
77	Vaginal atresia (HP:0000148)	1.90701391
78	Absent speech (HP:0001344)	1.89417775
79	Stomach cancer (HP:0012126)	1.87000464
80	Tachypnea (HP:0002789)	1.86201396
81	Optic nerve hypoplasia (HP:0000609)	1.86067500
82	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84051524
83	Clumsiness (HP:0002312)	1.83218595
84	Acute necrotizing encephalopathy (HP:0006965)	1.83066774
85	Severe muscular hypotonia (HP:0006829)	1.82370427
86	Postaxial foot polydactyly (HP:0001830)	1.82287002
87	Ketosis (HP:0001946)	1.81505305
88	Ketoacidosis (HP:0001993)	1.80655608
89	Abnormality of macular pigmentation (HP:0008002)	1.80222550
90	Congenital, generalized hypertrichosis (HP:0004540)	1.77809931
91	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77361635
92	Poor coordination (HP:0002370)	1.76766522
93	Abnormal urine output (HP:0012590)	1.76393124
94	Abnormality of the renal collecting system (HP:0004742)	1.75796350
95	Methylmalonic aciduria (HP:0012120)	1.74088831
96	Agitation (HP:0000713)	1.73636669
97	Optic disc pallor (HP:0000543)	1.73206364
98	Short tibia (HP:0005736)	1.71199827
99	Fair hair (HP:0002286)	1.70955224
100	Acute encephalopathy (HP:0006846)	1.69389623

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.86934645
2	BMPR1B	3.50852740
3	ADRBK2	3.20827019
4	ACVR1B	3.10873180
5	MAP4K2	3.00166293
6	ZAK	2.73124098
7	TLK1	2.47654880
8	TAOK3	2.37634228
9	WNK3	2.37615318
10	STK16	2.36436549
11	WNK4	2.30172988
12	GRK1	2.29874569
13	PINK1	2.11364955
14	INSRR	1.96640820
15	MAP3K4	1.93087978
16	NUAK1	1.84840867
17	DAPK2	1.84406736
18	MAPK13	1.80088755
19	CASK	1.71505936
20	TXK	1.46947811
21	OXSR1	1.44302932
22	MAP2K7	1.41498519
23	STK39	1.32833368
24	TNIK	1.21124076
25	PAK3	1.18251987
26	TGFBR1	1.18073329
27	NTRK3	1.16014360
28	ADRBK1	1.15604693
29	STK38L	1.10299942
30	CAMKK2	1.03226392
31	PTK2B	1.02313640
32	VRK1	1.00803172
33	PNCK	0.98636871
34	PRKCG	0.98017624
35	MARK1	0.97131940
36	PRKCE	0.95332295
37	MKNK2	0.93661386
38	PHKG2	0.93197166
39	PHKG1	0.93197166
40	TRIM28	0.92621214
41	BCKDK	0.84863884
42	EPHA4	0.83894942
43	MAPKAPK3	0.83849108
44	MAPK15	0.83567996
45	PIK3CA	0.83342036
46	DYRK2	0.81269329
47	BRSK2	0.75707298
48	OBSCN	0.75040776
49	PLK2	0.71317602
50	RPS6KA5	0.71121856
51	MAP2K6	0.69344666
52	TIE1	0.69222593
53	PKN1	0.67130415
54	NTRK2	0.66775096
55	CSNK1G2	0.65386316
56	NME1	0.64770845
57	MUSK	0.63779850
58	MAPKAPK5	0.62865727
59	CSNK1G1	0.60365423
60	CAMK1	0.59864375
61	PLK4	0.57917929
62	CSNK1G3	0.57663069
63	EPHA3	0.57513377
64	CAMK2A	0.56909234
65	PRKCQ	0.55812198
66	MAP2K4	0.55590031
67	CSNK1A1L	0.55490843
68	FGFR2	0.54960866
69	IKBKB	0.53576000
70	NEK2	0.53299793
71	AKT3	0.49873577
72	PIK3CG	0.48927494
73	PRKACA	0.46396826
74	PRKAA1	0.46289971
75	SIK2	0.45190527
76	ITK	0.45014649
77	CSNK1A1	0.43837211
78	PRKAA2	0.43732962
79	PRKCI	0.43631311
80	ERBB3	0.42468997
81	KIT	0.41484007
82	STK11	0.39784920
83	BCR	0.39534144
84	TEC	0.38870974
85	PRKCZ	0.38690589
86	CAMK4	0.37787041
87	IRAK1	0.37591638
88	WEE1	0.35997517
89	CAMK1D	0.34169387
90	WNK1	0.34166617
91	CHUK	0.33641849
92	TAF1	0.32640689
93	PRKG1	0.32265707
94	GRK7	0.31846136
95	PRKCA	0.31671896
96	MKNK1	0.31507210
97	NLK	0.30906015
98	CSNK1D	0.29895733
99	CHEK2	0.29637718
100	STK3	0.29173876

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.93403285
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.58260069
3	Nicotine addiction_Homo sapiens_hsa05033	2.51157175
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.49351120
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.45312819
6	Butanoate metabolism_Homo sapiens_hsa00650	2.43314342
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39013121
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.32810414
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.23216421
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.16012170
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.10603078
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.09197880
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.04713827
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.99154561
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.97774673
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96480713
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.89233107
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.74404171
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59575087
20	Homologous recombination_Homo sapiens_hsa03440	1.57780109
21	Morphine addiction_Homo sapiens_hsa05032	1.55068847
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.55034118
23	Olfactory transduction_Homo sapiens_hsa04740	1.53718233
24	RNA polymerase_Homo sapiens_hsa03020	1.51760101
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43841358
26	Parkinsons disease_Homo sapiens_hsa05012	1.43412094
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.42537449
28	Taste transduction_Homo sapiens_hsa04742	1.42195840
29	ABC transporters_Homo sapiens_hsa02010	1.40206618
30	Basal transcription factors_Homo sapiens_hsa03022	1.34903689
31	Caffeine metabolism_Homo sapiens_hsa00232	1.30446226
32	Insulin secretion_Homo sapiens_hsa04911	1.25094761
33	Propanoate metabolism_Homo sapiens_hsa00640	1.23897778
34	GABAergic synapse_Homo sapiens_hsa04727	1.22044515
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18608598
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.14320995
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.13633200
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12820927
39	Circadian entrainment_Homo sapiens_hsa04713	1.12257370
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11118898
41	Protein export_Homo sapiens_hsa03060	1.09787456
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06426817
43	Huntingtons disease_Homo sapiens_hsa05016	1.05958133
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.05458508
45	Serotonergic synapse_Homo sapiens_hsa04726	1.05440745
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03671559
47	RNA degradation_Homo sapiens_hsa03018	0.99859748
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99723279
49	Peroxisome_Homo sapiens_hsa04146	0.98638348
50	Regulation of autophagy_Homo sapiens_hsa04140	0.97918910
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97808618
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97200486
53	One carbon pool by folate_Homo sapiens_hsa00670	0.95114149
54	Sulfur metabolism_Homo sapiens_hsa00920	0.94547403
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.93805891
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.92325556
57	Salivary secretion_Homo sapiens_hsa04970	0.89747270
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89209064
59	Alzheimers disease_Homo sapiens_hsa05010	0.88859774
60	Retinol metabolism_Homo sapiens_hsa00830	0.85148365
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79081676
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76658401
63	Purine metabolism_Homo sapiens_hsa00230	0.75052957
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73805626
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.72870023
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.70042835
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69491965
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.67777067
69	Cocaine addiction_Homo sapiens_hsa05030	0.66056429
70	Histidine metabolism_Homo sapiens_hsa00340	0.64918043
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61274952
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59991430
73	Metabolic pathways_Homo sapiens_hsa01100	0.58848023
74	Circadian rhythm_Homo sapiens_hsa04710	0.57701825
75	Amphetamine addiction_Homo sapiens_hsa05031	0.56673372
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.54829589
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51689653
78	Mineral absorption_Homo sapiens_hsa04978	0.50338041
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48984578
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.48510878
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.45809099
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45795906
83	Graft-versus-host disease_Homo sapiens_hsa05332	0.45640038
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45448975
85	Type I diabetes mellitus_Homo sapiens_hsa04940	0.45150468
86	Cholinergic synapse_Homo sapiens_hsa04725	0.44303061
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44268033
88	Sulfur relay system_Homo sapiens_hsa04122	0.43461388
89	Asthma_Homo sapiens_hsa05310	0.42780975
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40155614
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.39682411
92	Renin secretion_Homo sapiens_hsa04924	0.39621702
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39325850
94	Primary immunodeficiency_Homo sapiens_hsa05340	0.38580081
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37779361
96	Long-term depression_Homo sapiens_hsa04730	0.37624511
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37514631
98	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37280289
99	Gastric acid secretion_Homo sapiens_hsa04971	0.37051372
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36640268

ZNF774

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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