ZNF778

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.24508754
2regulation of posttranscriptional gene silencing (GO:0060147)4.03868365
3regulation of gene silencing by miRNA (GO:0060964)4.03868365
4regulation of gene silencing by RNA (GO:0060966)4.03868365
5synapsis (GO:0007129)3.82669954
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.78174273
7negative regulation of translation, ncRNA-mediated (GO:0040033)3.78174273
8regulation of translation, ncRNA-mediated (GO:0045974)3.78174273
9piRNA metabolic process (GO:0034587)3.40509113
10response to pheromone (GO:0019236)3.38810492
11pyrimidine nucleobase catabolic process (GO:0006208)3.35843849
12regulation of hippo signaling (GO:0035330)3.35467490
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24190513
14DNA methylation involved in gamete generation (GO:0043046)3.15060772
15regulation of nuclear cell cycle DNA replication (GO:0033262)3.03081553
16male meiosis I (GO:0007141)3.00805189
17male meiosis (GO:0007140)2.98846588
18multicellular organism reproduction (GO:0032504)2.91176669
19histone H3-K9 methylation (GO:0051567)2.85954566
20replication fork processing (GO:0031297)2.84894281
21nucleobase catabolic process (GO:0046113)2.82357617
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80108741
23mating behavior (GO:0007617)2.79284443
24negative regulation of transcription regulatory region DNA binding (GO:2000678)2.78604048
25neuron cell-cell adhesion (GO:0007158)2.75630864
26glycerophospholipid catabolic process (GO:0046475)2.70902454
27epithelial cilium movement (GO:0003351)2.70489135
28presynaptic membrane assembly (GO:0097105)2.68830663
29resolution of meiotic recombination intermediates (GO:0000712)2.65918277
30spermatid development (GO:0007286)2.64781308
31sperm motility (GO:0030317)2.62636424
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62329760
33acrosome reaction (GO:0007340)2.61861069
34prenylation (GO:0097354)2.59305809
35protein prenylation (GO:0018342)2.59305809
36protein polyglutamylation (GO:0018095)2.58973492
37chromosome organization involved in meiosis (GO:0070192)2.58026472
38snRNA transcription (GO:0009301)2.55685099
39meiotic chromosome segregation (GO:0045132)2.54867300
40centriole replication (GO:0007099)2.53914126
41regulation of action potential (GO:0098900)2.53316994
42neuronal action potential (GO:0019228)2.52623669
43spinal cord development (GO:0021510)2.51927892
44genitalia morphogenesis (GO:0035112)2.51072519
45protein K11-linked deubiquitination (GO:0035871)2.50217907
46cellular ketone body metabolic process (GO:0046950)2.49920802
47presynaptic membrane organization (GO:0097090)2.47186493
48nonmotile primary cilium assembly (GO:0035058)2.46731966
49cornea development in camera-type eye (GO:0061303)2.46006250
50transmission of nerve impulse (GO:0019226)2.45634818
51regulation of telomere maintenance (GO:0032204)2.45111120
52gene silencing by RNA (GO:0031047)2.44308061
53embryonic body morphogenesis (GO:0010172)2.43701865
54somatic hypermutation of immunoglobulin genes (GO:0016446)2.42660469
55somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42660469
56sulfation (GO:0051923)2.40922900
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.40108750
58cell proliferation in forebrain (GO:0021846)2.40041096
59reciprocal meiotic recombination (GO:0007131)2.38809237
60reciprocal DNA recombination (GO:0035825)2.38809237
61detection of light stimulus involved in visual perception (GO:0050908)2.38641599
62detection of light stimulus involved in sensory perception (GO:0050962)2.38641599
63postsynaptic membrane organization (GO:0001941)2.37858411
64gamma-aminobutyric acid transport (GO:0015812)2.37410284
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.36839006
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.36839006
67NADH dehydrogenase complex assembly (GO:0010257)2.36839006
68DNA alkylation (GO:0006305)2.36486277
69DNA methylation (GO:0006306)2.36486277
70regulation of meiosis I (GO:0060631)2.36099209
71positive regulation of gastrulation (GO:2000543)2.33561239
72spinal cord motor neuron differentiation (GO:0021522)2.32476913
73meiosis I (GO:0007127)2.31878555
74recombinational repair (GO:0000725)2.29517013
75regulation of collateral sprouting (GO:0048670)2.28762938
76double-strand break repair via homologous recombination (GO:0000724)2.27850253
77neuromuscular synaptic transmission (GO:0007274)2.27258998
78protein import into peroxisome matrix (GO:0016558)2.26941764
79cilium movement (GO:0003341)2.26824599
80cellular response to ATP (GO:0071318)2.26181497
81DNA replication checkpoint (GO:0000076)2.26084132
82L-fucose catabolic process (GO:0042355)2.24410970
83fucose catabolic process (GO:0019317)2.24410970
84L-fucose metabolic process (GO:0042354)2.24410970
85regulation of acrosome reaction (GO:0060046)2.24367125
86kynurenine metabolic process (GO:0070189)2.23247415
87reflex (GO:0060004)2.22709218
88cilium organization (GO:0044782)2.22333819
89cAMP catabolic process (GO:0006198)2.22124027
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.22030814
91somite development (GO:0061053)2.21791479
92cilium assembly (GO:0042384)2.21246561
93kidney morphogenesis (GO:0060993)2.20768662
94retinal ganglion cell axon guidance (GO:0031290)2.20737443
95rhodopsin mediated signaling pathway (GO:0016056)2.20675091
96peptidyl-histidine modification (GO:0018202)2.20069445
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.19347311
98membrane depolarization during action potential (GO:0086010)2.19003908
99body morphogenesis (GO:0010171)2.18361294
100indolalkylamine metabolic process (GO:0006586)2.17898272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61646570
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.54171136
3ZNF274_21170338_ChIP-Seq_K562_Hela3.47274176
4IGF1R_20145208_ChIP-Seq_DFB_Human3.04863355
5GBX2_23144817_ChIP-Seq_PC3_Human2.96088671
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.83212671
7VDR_22108803_ChIP-Seq_LS180_Human2.69856878
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49218618
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39063868
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31473059
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23831952
12ER_23166858_ChIP-Seq_MCF-7_Human2.13571515
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11728086
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09808334
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07183424
16EWS_26573619_Chip-Seq_HEK293_Human2.05998674
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02631312
18FUS_26573619_Chip-Seq_HEK293_Human2.01389441
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95924812
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84468438
21TAF15_26573619_Chip-Seq_HEK293_Human1.78943462
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77193695
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76817571
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.71813143
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.71690397
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70893619
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68215126
28P300_19829295_ChIP-Seq_ESCs_Human1.67327185
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65945624
30REST_21632747_ChIP-Seq_MESCs_Mouse1.63579967
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60900115
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60900115
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55334127
34RNF2_27304074_Chip-Seq_NSC_Mouse1.52947504
35IRF1_19129219_ChIP-ChIP_H3396_Human1.51194424
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.51172955
37AR_21572438_ChIP-Seq_LNCaP_Human1.39763010
38* STAT3_23295773_ChIP-Seq_U87_Human1.39236947
39SMAD4_21799915_ChIP-Seq_A2780_Human1.39124849
40* TCF4_23295773_ChIP-Seq_U87_Human1.37290637
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36250627
42MYC_18940864_ChIP-ChIP_HL60_Human1.35307158
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.35202911
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34409562
45CBP_20019798_ChIP-Seq_JUKART_Human1.34409562
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31509368
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30205599
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.28668493
49* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28252639
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27618204
51BCAT_22108803_ChIP-Seq_LS180_Human1.27314203
52TP53_22573176_ChIP-Seq_HFKS_Human1.26387211
53AR_25329375_ChIP-Seq_VCAP_Human1.26231836
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24367197
55HOXB7_26014856_ChIP-Seq_BT474_Human1.22891306
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.22367670
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19454004
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17068888
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16558282
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.16001541
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15677192
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.12110606
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12056732
64RUNX2_22187159_ChIP-Seq_PCA_Human1.11985807
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10979424
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10419486
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.09013293
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07428666
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06963062
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06423622
71WDR5_24793694_ChIP-Seq_LNCAP_Human1.03514396
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.03017719
73AHR_22903824_ChIP-Seq_MCF-7_Human1.01865847
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.00798002
75KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97440729
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95385693
77EZH2_27294783_Chip-Seq_ESCs_Mouse0.93887554
78FLI1_21867929_ChIP-Seq_TH2_Mouse0.93695316
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93606850
80NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92689084
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.91602875
82NCOR_22424771_ChIP-Seq_293T_Human0.91531929
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90507099
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.89094738
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.88602372
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88234256
87JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87967551
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87432100
89TCF4_22108803_ChIP-Seq_LS180_Human0.87189865
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.86554163
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86286482
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.85861262
93EST1_17652178_ChIP-ChIP_JURKAT_Human0.85388808
94AR_19668381_ChIP-Seq_PC3_Human0.84965505
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84560366
96E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84374809
97SOX9_26525672_Chip-Seq_HEART_Mouse0.84206054
98ERA_21632823_ChIP-Seq_H3396_Human0.84047930
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83917225
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.83646628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.17008346
2MP0003787_abnormal_imprinting3.31975732
3MP0005646_abnormal_pituitary_gland2.47665937
4MP0003136_yellow_coat_color2.19559251
5MP0003121_genomic_imprinting1.93450685
6MP0000569_abnormal_digit_pigmentation1.92828459
7MP0000631_abnormal_neuroendocrine_gland1.80098450
8MP0002653_abnormal_ependyma_morphology1.79289314
9MP0006292_abnormal_olfactory_placode1.78524673
10MP0002160_abnormal_reproductive_system1.75545303
11MP0001529_abnormal_vocalization1.75304443
12MP0005551_abnormal_eye_electrophysiolog1.73850978
13MP0003890_abnormal_embryonic-extraembry1.71110973
14MP0001968_abnormal_touch/_nociception1.68798211
15MP0006276_abnormal_autonomic_nervous1.60092531
16MP0002163_abnormal_gland_morphology1.59093228
17MP0000427_abnormal_hair_cycle1.59034661
18MP0000778_abnormal_nervous_system1.58035708
19MP0004133_heterotaxia1.56237414
20MP0001502_abnormal_circadian_rhythm1.52928156
21MP0001188_hyperpigmentation1.50128786
22MP0003195_calcinosis1.48397762
23MP0008872_abnormal_physiological_respon1.46255508
24MP0004142_abnormal_muscle_tone1.44501974
25MP0005379_endocrine/exocrine_gland_phen1.44492918
26MP0002184_abnormal_innervation1.43500109
27MP0002210_abnormal_sex_determination1.43439136
28MP0005423_abnormal_somatic_nervous1.37939083
29MP0003123_paternal_imprinting1.37908201
30MP0002272_abnormal_nervous_system1.37395437
31MP0009745_abnormal_behavioral_response1.37204116
32MP0005645_abnormal_hypothalamus_physiol1.36886617
33MP0003646_muscle_fatigue1.36788184
34MP0009046_muscle_twitch1.36408154
35MP0002735_abnormal_chemical_nociception1.35964191
36MP0003122_maternal_imprinting1.33949184
37MP0005389_reproductive_system_phenotype1.33909095
38MP0003718_maternal_effect1.33806562
39MP0003698_abnormal_male_reproductive1.33074668
40MP0003937_abnormal_limbs/digits/tail_de1.30640706
41MP0001929_abnormal_gametogenesis1.30306032
42MP0001919_abnormal_reproductive_system1.29751572
43MP0001485_abnormal_pinna_reflex1.27056423
44MP0005377_hearing/vestibular/ear_phenot1.25475982
45MP0003878_abnormal_ear_physiology1.25475982
46MP0005410_abnormal_fertilization1.24727181
47MP0006072_abnormal_retinal_apoptosis1.23794860
48MP0008058_abnormal_DNA_repair1.23629873
49MP0002557_abnormal_social/conspecific_i1.22681081
50MP0002837_dystrophic_cardiac_calcinosis1.20959339
51MP0002909_abnormal_adrenal_gland1.20210996
52MP0002736_abnormal_nociception_after1.19465123
53MP0002102_abnormal_ear_morphology1.18469081
54MP0008057_abnormal_DNA_replication1.17354687
55MP0008995_early_reproductive_senescence1.15630482
56MP0004270_analgesia1.15340574
57MP0004885_abnormal_endolymph1.14358344
58MP0002572_abnormal_emotion/affect_behav1.13778075
59MP0002063_abnormal_learning/memory/cond1.13560374
60MP0002938_white_spotting1.13557047
61MP0001293_anophthalmia1.12643432
62MP0003635_abnormal_synaptic_transmissio1.12067726
63MP0008789_abnormal_olfactory_epithelium1.10933197
64MP0005174_abnormal_tail_pigmentation1.10908065
65MP0000955_abnormal_spinal_cord1.09424322
66MP0003119_abnormal_digestive_system1.09333461
67MP0002734_abnormal_mechanical_nocicepti1.08674429
68MP0002067_abnormal_sensory_capabilities1.07828024
69MP0005253_abnormal_eye_physiology1.07460783
70MP0001145_abnormal_male_reproductive1.06965356
71MP0004130_abnormal_muscle_cell1.06096848
72MP0002064_seizures1.05969805
73MP0002752_abnormal_somatic_nervous1.05875011
74MP0005394_taste/olfaction_phenotype1.03468555
75MP0005499_abnormal_olfactory_system1.03468555
76MP0000653_abnormal_sex_gland1.03089890
77MP0002638_abnormal_pupillary_reflex1.02433004
78MP0003861_abnormal_nervous_system1.02394275
79MP0003880_abnormal_central_pattern1.01964173
80MP0001486_abnormal_startle_reflex1.00445721
81MP0000049_abnormal_middle_ear1.00387266
82MP0003693_abnormal_embryo_hatching0.97312018
83MP0004145_abnormal_muscle_electrophysio0.96611635
84MP0005386_behavior/neurological_phenoty0.96286229
85MP0004924_abnormal_behavior0.96286229
86MP0010094_abnormal_chromosome_stability0.96184535
87MP0002751_abnormal_autonomic_nervous0.95654707
88MP0004742_abnormal_vestibular_system0.93313278
89MP0002733_abnormal_thermal_nociception0.92078253
90MP0003942_abnormal_urinary_system0.91630915
91MP0002882_abnormal_neuron_morphology0.91408234
92MP0002152_abnormal_brain_morphology0.90642174
93MP0000383_abnormal_hair_follicle0.89528716
94MP0005187_abnormal_penis_morphology0.89108128
95MP0004043_abnormal_pH_regulation0.88342008
96MP0005195_abnormal_posterior_eye0.86782947
97MP0001970_abnormal_pain_threshold0.86173387
98MP0002928_abnormal_bile_duct0.85595424
99MP0002233_abnormal_nose_morphology0.84631029
100MP0003755_abnormal_palate_morphology0.82278518

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.89317417
2Pancreatic fibrosis (HP:0100732)3.56403093
3Molar tooth sign on MRI (HP:0002419)3.43442712
4Abnormality of midbrain morphology (HP:0002418)3.43442712
5Nephronophthisis (HP:0000090)3.17100067
6True hermaphroditism (HP:0010459)3.15555778
7Congenital stationary night blindness (HP:0007642)3.12913988
8Chronic hepatic failure (HP:0100626)2.96958163
9Pendular nystagmus (HP:0012043)2.90423183
10Type II lissencephaly (HP:0007260)2.83896473
11Concave nail (HP:0001598)2.77212994
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.66991069
13Attenuation of retinal blood vessels (HP:0007843)2.59077013
14Abnormality of the renal medulla (HP:0100957)2.56842019
15Protruding tongue (HP:0010808)2.54996577
16Genetic anticipation (HP:0003743)2.52952108
17Hypoplasia of the pons (HP:0012110)2.52921927
18Cystic liver disease (HP:0006706)2.51690897
19Progressive cerebellar ataxia (HP:0002073)2.46736115
20Abnormality of the labia minora (HP:0012880)2.46142722
21Cerebellar dysplasia (HP:0007033)2.45538771
22Birth length less than 3rd percentile (HP:0003561)2.42715833
23Abnormality of the pons (HP:0007361)2.40098727
24Patellar aplasia (HP:0006443)2.32304807
25Bony spicule pigmentary retinopathy (HP:0007737)2.31534333
26Abnormality of the ileum (HP:0001549)2.30732548
27Meckel diverticulum (HP:0002245)2.30002975
28Lissencephaly (HP:0001339)2.26537034
29Broad-based gait (HP:0002136)2.26532976
30Sclerocornea (HP:0000647)2.25757961
31Aplasia/Hypoplasia of the patella (HP:0006498)2.25076984
32Pachygyria (HP:0001302)2.24770728
33Hyperventilation (HP:0002883)2.22077506
34Gaze-evoked nystagmus (HP:0000640)2.19484606
35Abnormal rod and cone electroretinograms (HP:0008323)2.18037537
36Abnormality of the renal cortex (HP:0011035)2.18009005
37Optic nerve hypoplasia (HP:0000609)2.17041062
38Anencephaly (HP:0002323)2.17030161
39Abnormality of the carotid arteries (HP:0005344)2.16464066
40Decreased central vision (HP:0007663)2.15031073
41Abnormality of alanine metabolism (HP:0010916)2.10528528
42Hyperalaninemia (HP:0003348)2.10528528
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10528528
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.09440566
45Inability to walk (HP:0002540)2.08047530
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03366083
47Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98582194
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98197810
49Septo-optic dysplasia (HP:0100842)1.92804781
50Small hand (HP:0200055)1.92517676
51Ectopic kidney (HP:0000086)1.90984929
52Progressive inability to walk (HP:0002505)1.89755288
53Medial flaring of the eyebrow (HP:0010747)1.88024962
54Chromsome breakage (HP:0040012)1.87563733
55Tubular atrophy (HP:0000092)1.87487438
56Agitation (HP:0000713)1.87231523
57Male pseudohermaphroditism (HP:0000037)1.85931738
58Abnormal drinking behavior (HP:0030082)1.85914102
59Polydipsia (HP:0001959)1.85914102
60Abolished electroretinogram (ERG) (HP:0000550)1.85854192
61Clumsiness (HP:0002312)1.85014882
62Aplasia/Hypoplasia of the tibia (HP:0005772)1.82935869
63Colon cancer (HP:0003003)1.82010361
64Drooling (HP:0002307)1.78559192
65Preaxial hand polydactyly (HP:0001177)1.78305134
66Absent thumb (HP:0009777)1.76007512
67Sloping forehead (HP:0000340)1.74904766
68Dandy-Walker malformation (HP:0001305)1.73349752
69Truncal obesity (HP:0001956)1.72261593
70Furrowed tongue (HP:0000221)1.71147938
71Abnormality of homocysteine metabolism (HP:0010919)1.70500942
72Homocystinuria (HP:0002156)1.70500942
73Febrile seizures (HP:0002373)1.68618020
74Facial hemangioma (HP:0000329)1.68198361
75Abnormality of the preputium (HP:0100587)1.68006224
76Poor coordination (HP:0002370)1.67904797
77Abnormal biliary tract physiology (HP:0012439)1.67117424
78Bile duct proliferation (HP:0001408)1.67117424
79Abnormality of chromosome stability (HP:0003220)1.66509178
80Infertility (HP:0000789)1.66048687
81Glioma (HP:0009733)1.65696406
82Absent/shortened dynein arms (HP:0200106)1.65229305
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.65229305
84Chorioretinal atrophy (HP:0000533)1.65223741
85Congenital hepatic fibrosis (HP:0002612)1.64797295
86Genital tract atresia (HP:0001827)1.64492234
87Midline defect of the nose (HP:0004122)1.62830765
88Short thumb (HP:0009778)1.61279654
89Clubbing of toes (HP:0100760)1.60156495
90Severe muscular hypotonia (HP:0006829)1.58506270
91Keratoconus (HP:0000563)1.56968523
92Increased corneal curvature (HP:0100692)1.56968523
93Methylmalonic acidemia (HP:0002912)1.56414025
94Broad alveolar ridges (HP:0000187)1.56025070
95Impulsivity (HP:0100710)1.55840754
96Bifid tongue (HP:0010297)1.54895152
97Astrocytoma (HP:0009592)1.54435398
98Abnormality of the astrocytes (HP:0100707)1.54435398
99Highly arched eyebrow (HP:0002553)1.52796639
100Astigmatism (HP:0000483)1.52772479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.62918477
2PINK13.45044572
3ZAK3.16803047
4CASK2.69982388
5ADRBK22.52041512
6PNCK2.52023413
7WNK32.47422482
8TNIK2.39876174
9MUSK2.27358507
10MAP3K42.25218095
11WNK42.21952299
12BMPR1B2.01901518
13GRK11.98113027
14MAP2K71.96268749
15TLK11.78369604
16NTRK31.70766971
17MARK11.68806391
18NUAK11.65590910
19DYRK21.57731678
20MAPK131.56150500
21NTRK21.52895243
22TAOK31.51048156
23CAMK1G1.41797063
24NEK21.39784567
25TRIM281.37805905
26MAP3K91.30404510
27DYRK31.27505814
28AKT31.24114103
29SIK21.22527177
30INSRR1.21534589
31CAMK1D1.17447438
32TAF11.13881546
33STK38L1.10985191
34MKNK21.08624820
35TYRO31.06124296
36CDC71.02701881
37PHKG21.02245822
38PHKG11.02245822
39MAP2K41.01132588
40OBSCN0.96786665
41ACVR1B0.96400521
42PLK40.95785389
43LATS10.95224464
44STK390.92954310
45SGK20.85764216
46CSNK1G20.85404671
47BRD40.85036345
48PAK30.84039643
49MAP4K20.83962234
50PRKCG0.82510574
51CSNK1G10.76714952
52OXSR10.73822149
53PKN10.73366051
54CSNK1G30.73123329
55ATR0.70713645
56RPS6KB10.70117142
57PIK3CA0.68780445
58CAMK10.67816065
59DAPK20.67402669
60SGK2230.67227358
61SGK4940.67227358
62MAPKAPK30.67099641
63CHEK20.66146875
64FGFR20.65420876
65CAMKK20.65346139
66STK30.64280539
67WNK10.64176548
68CSNK1A1L0.62694242
69CSNK1E0.61625236
70BRSK20.61406878
71VRK10.60712014
72CSNK1D0.58500788
73PRKCE0.57855939
74CDK120.56626745
75PRKAA10.56441352
76TIE10.54374434
77PLK10.54273168
78ATM0.54185377
79STK110.52364998
80MST40.51715142
81ADRBK10.50485610
82RPS6KB20.49689456
83TSSK60.49609134
84PLK20.48661793
85TNK20.48351977
86RPS6KA50.47848732
87PTK2B0.46914379
88CAMK40.46100750
89CDK190.44662417
90NME10.44613045
91PRKG10.44215504
92CHEK10.42837316
93EPHA30.36791331
94CDK10.36737386
95GSK3B0.36721920
96PRKACB0.36702583
97CSNK1A10.36548131
98WEE10.36416813
99PLK30.35541050
100CDK30.35052105

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.47331630
2Phototransduction_Homo sapiens_hsa047442.80666500
3Fanconi anemia pathway_Homo sapiens_hsa034602.45785527
4Nicotine addiction_Homo sapiens_hsa050332.31229378
5Basal transcription factors_Homo sapiens_hsa030222.23613787
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21121734
7RNA polymerase_Homo sapiens_hsa030202.18903146
8Homologous recombination_Homo sapiens_hsa034402.07318152
9Butanoate metabolism_Homo sapiens_hsa006501.91484828
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90334049
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86143463
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67821101
13Olfactory transduction_Homo sapiens_hsa047401.64869672
14Circadian entrainment_Homo sapiens_hsa047131.62216821
15One carbon pool by folate_Homo sapiens_hsa006701.59656885
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58060213
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57542095
18Morphine addiction_Homo sapiens_hsa050321.53165276
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.49901031
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47915997
21Linoleic acid metabolism_Homo sapiens_hsa005911.42298087
22Nitrogen metabolism_Homo sapiens_hsa009101.37055997
23Hedgehog signaling pathway_Homo sapiens_hsa043401.36618126
24Taste transduction_Homo sapiens_hsa047421.35785336
25GABAergic synapse_Homo sapiens_hsa047271.33947023
26Glutamatergic synapse_Homo sapiens_hsa047241.33129709
27Cardiac muscle contraction_Homo sapiens_hsa042601.29778696
28RNA degradation_Homo sapiens_hsa030181.28529896
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25262932
30Insulin secretion_Homo sapiens_hsa049111.24430000
31Basal cell carcinoma_Homo sapiens_hsa052171.22670216
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21701601
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20137626
34RNA transport_Homo sapiens_hsa030131.18541730
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11661249
36Serotonergic synapse_Homo sapiens_hsa047261.10114613
37Circadian rhythm_Homo sapiens_hsa047101.07478753
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05764338
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04739218
40Hippo signaling pathway_Homo sapiens_hsa043901.00421796
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99511139
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96075135
43Ether lipid metabolism_Homo sapiens_hsa005650.95903408
44Lysine degradation_Homo sapiens_hsa003100.94970671
45Cholinergic synapse_Homo sapiens_hsa047250.94936478
46Ovarian steroidogenesis_Homo sapiens_hsa049130.93213228
47Tryptophan metabolism_Homo sapiens_hsa003800.93082735
48Oxidative phosphorylation_Homo sapiens_hsa001900.92385714
49Propanoate metabolism_Homo sapiens_hsa006400.91250504
50Sulfur relay system_Homo sapiens_hsa041220.90439716
51Axon guidance_Homo sapiens_hsa043600.90210281
52Parkinsons disease_Homo sapiens_hsa050120.89817175
53Dopaminergic synapse_Homo sapiens_hsa047280.88230181
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87317801
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83352864
56Long-term depression_Homo sapiens_hsa047300.80757722
57Dorso-ventral axis formation_Homo sapiens_hsa043200.80448630
58Alcoholism_Homo sapiens_hsa050340.79805773
59Purine metabolism_Homo sapiens_hsa002300.77878352
60Regulation of autophagy_Homo sapiens_hsa041400.77686186
61Calcium signaling pathway_Homo sapiens_hsa040200.76891150
62mRNA surveillance pathway_Homo sapiens_hsa030150.73578421
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73255708
64Melanoma_Homo sapiens_hsa052180.72933958
65Huntingtons disease_Homo sapiens_hsa050160.72779983
66Oxytocin signaling pathway_Homo sapiens_hsa049210.71686089
67Steroid biosynthesis_Homo sapiens_hsa001000.65489526
68Cocaine addiction_Homo sapiens_hsa050300.65224631
69cAMP signaling pathway_Homo sapiens_hsa040240.64375192
70Cell cycle_Homo sapiens_hsa041100.63171324
71Wnt signaling pathway_Homo sapiens_hsa043100.61701183
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.60259299
73Type II diabetes mellitus_Homo sapiens_hsa049300.60178976
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59826814
75Nucleotide excision repair_Homo sapiens_hsa034200.58422592
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58194629
77Oocyte meiosis_Homo sapiens_hsa041140.57951172
78Fatty acid biosynthesis_Homo sapiens_hsa000610.57930649
79Non-homologous end-joining_Homo sapiens_hsa034500.56296062
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55260097
81Pyrimidine metabolism_Homo sapiens_hsa002400.55229270
82ABC transporters_Homo sapiens_hsa020100.52930597
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52194036
84Gap junction_Homo sapiens_hsa045400.51478671
85TGF-beta signaling pathway_Homo sapiens_hsa043500.51266398
86MAPK signaling pathway_Homo sapiens_hsa040100.49956043
87Inositol phosphate metabolism_Homo sapiens_hsa005620.48248835
88Caffeine metabolism_Homo sapiens_hsa002320.46956655
89Protein export_Homo sapiens_hsa030600.45162014
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44657545
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42205238
92Alzheimers disease_Homo sapiens_hsa050100.41589574
93Mismatch repair_Homo sapiens_hsa034300.41341557
94Gastric acid secretion_Homo sapiens_hsa049710.40534822
95Ras signaling pathway_Homo sapiens_hsa040140.40055171
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39776086
97FoxO signaling pathway_Homo sapiens_hsa040680.39427445
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39396852
99beta-Alanine metabolism_Homo sapiens_hsa004100.38769344
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.38703195

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