ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.93184178
2	neural tube formation (GO:0001841)	4.31342847
3	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.73750174
4	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.73750174
5	regulation of translation, ncRNA-mediated (GO:0045974)	3.73750174
6	cytoplasmic mRNA processing body assembly (GO:0033962)	3.69631234
7	rRNA catabolic process (GO:0016075)	3.63821317
8	protein K11-linked deubiquitination (GO:0035871)	3.51986743
9	interkinetic nuclear migration (GO:0022027)	3.43901661
10	protein prenylation (GO:0018342)	3.41919880
11	prenylation (GO:0097354)	3.41919880
12	L-fucose catabolic process (GO:0042355)	3.37348272
13	fucose catabolic process (GO:0019317)	3.37348272
14	L-fucose metabolic process (GO:0042354)	3.37348272
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.34237261
16	establishment of protein localization to Golgi (GO:0072600)	3.33655932
17	cAMP catabolic process (GO:0006198)	3.22647395
18	gamma-aminobutyric acid transport (GO:0015812)	3.17757376
19	monoubiquitinated protein deubiquitination (GO:0035520)	3.16922470
20	regulation of pigment cell differentiation (GO:0050932)	3.09330824
21	cilium or flagellum-dependent cell motility (GO:0001539)	3.04063894
22	positive regulation of developmental pigmentation (GO:0048087)	3.01886039
23	cellular response to ethanol (GO:0071361)	3.00153822
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99710616
25	regulation of hippo signaling (GO:0035330)	2.99509685
26	presynaptic membrane assembly (GO:0097105)	2.96490809
27	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.94502174
28	kidney morphogenesis (GO:0060993)	2.93780351
29	cyclic nucleotide catabolic process (GO:0009214)	2.93361539
30	histone H3-K4 trimethylation (GO:0080182)	2.93095018
31	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.85379534
32	cellular response to sterol (GO:0036315)	2.85348113
33	protein targeting to Golgi (GO:0000042)	2.84819711
34	indolalkylamine metabolic process (GO:0006586)	2.83419461
35	pyrimidine nucleobase catabolic process (GO:0006208)	2.82585826
36	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.80550616
37	primary amino compound metabolic process (GO:1901160)	2.78321034
38	nonmotile primary cilium assembly (GO:0035058)	2.75834788
39	serotonin metabolic process (GO:0042428)	2.74308383
40	response to pheromone (GO:0019236)	2.73129672
41	spinal cord motor neuron differentiation (GO:0021522)	2.72856386
42	positive regulation of CREB transcription factor activity (GO:0032793)	2.72800441
43	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.72604069
44	detection of light stimulus involved in visual perception (GO:0050908)	2.72448188
45	detection of light stimulus involved in sensory perception (GO:0050962)	2.72448188
46	activated T cell proliferation (GO:0050798)	2.71409940
47	nucleus localization (GO:0051647)	2.70423229
48	cilium organization (GO:0044782)	2.68967073
49	inner ear receptor stereocilium organization (GO:0060122)	2.68146456
50	presynaptic membrane organization (GO:0097090)	2.66799379
51	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.66009380
52	somite development (GO:0061053)	2.65408720
53	cilium assembly (GO:0042384)	2.63713435
54	cerebellar Purkinje cell differentiation (GO:0021702)	2.63053026
55	reflex (GO:0060004)	2.61753016
56	cellular ketone body metabolic process (GO:0046950)	2.61370977
57	atrial cardiac muscle cell action potential (GO:0086014)	2.60521356
58	Golgi to endosome transport (GO:0006895)	2.59023690
59	peptidyl-lysine trimethylation (GO:0018023)	2.58436530
60	neuronal action potential (GO:0019228)	2.54846898
61	axoneme assembly (GO:0035082)	2.54532340
62	central nervous system neuron axonogenesis (GO:0021955)	2.54459720
63	appendage development (GO:0048736)	2.54438943
64	limb development (GO:0060173)	2.54438943
65	regulation of sarcomere organization (GO:0060297)	2.54203987
66	membrane depolarization during action potential (GO:0086010)	2.53993101
67	behavioral response to ethanol (GO:0048149)	2.53229054
68	neurotransmitter-gated ion channel clustering (GO:0072578)	2.50971210
69	neuronal action potential propagation (GO:0019227)	2.50390255
70	microtubule anchoring (GO:0034453)	2.49291160
71	nucleobase catabolic process (GO:0046113)	2.49028417
72	somite rostral/caudal axis specification (GO:0032525)	2.48598238
73	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.47817473
74	histone-serine phosphorylation (GO:0035404)	2.47698733
75	reciprocal DNA recombination (GO:0035825)	2.47449775
76	reciprocal meiotic recombination (GO:0007131)	2.47449775
77	embryonic epithelial tube formation (GO:0001838)	2.47207980
78	protein localization to cilium (GO:0061512)	2.46482381
79	synaptic transmission, cholinergic (GO:0007271)	2.45690324
80	phospholipid translocation (GO:0045332)	2.44741029
81	lipid translocation (GO:0034204)	2.44741029
82	head development (GO:0060322)	2.44556893
83	central nervous system projection neuron axonogenesis (GO:0021952)	2.44353389
84	photoreceptor cell maintenance (GO:0045494)	2.43147494
85	cilium morphogenesis (GO:0060271)	2.41847815
86	protein localization to Golgi apparatus (GO:0034067)	2.41698161
87	regulation of collateral sprouting (GO:0048670)	2.40604498
88	cellular response to cholesterol (GO:0071397)	2.39475363
89	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.39142450
90	protein K48-linked deubiquitination (GO:0071108)	2.38862947
91	indole-containing compound metabolic process (GO:0042430)	2.38065745
92	peptidyl-lysine methylation (GO:0018022)	2.36460536
93	histone H3-K9 methylation (GO:0051567)	2.36413733
94	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.36312125
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.35003907
96	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.33074576
97	regulation of gene silencing by RNA (GO:0060966)	2.32903017
98	regulation of posttranscriptional gene silencing (GO:0060147)	2.32903017
99	regulation of gene silencing by miRNA (GO:0060964)	2.32903017
100	indolalkylamine catabolic process (GO:0046218)	2.32652709

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.49758010
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11820193
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.03045224
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.89508037
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.88007448
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.64873964
7	VDR_22108803_ChIP-Seq_LS180_Human	2.62098373
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61546163
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56469166
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.56209181
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.54993552
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.52105478
13	FUS_26573619_Chip-Seq_HEK293_Human	2.33155464
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.19056371
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.14419969
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13486441
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12761128
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.06481071
19	EWS_26573619_Chip-Seq_HEK293_Human	2.05684235
20	P300_19829295_ChIP-Seq_ESCs_Human	2.03093047
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92387720
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.90857405
23	STAT3_23295773_ChIP-Seq_U87_Human	1.89914246
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.87914488
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83356840
26	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.82557337
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.77058291
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.74373648
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.68605657
30	TCF4_23295773_ChIP-Seq_U87_Human	1.66163414
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65802876
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64339898
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62755415
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.58697857
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58697857
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.58533679
37	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.55031532
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.53436755
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52935435
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.52935435
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.52515074
42	AR_25329375_ChIP-Seq_VCAP_Human	1.49728383
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49486057
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48407566
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47727375
46	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.45321526
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.42233061
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42087538
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.41315019
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40829590
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.36236785
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34846417
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32451723
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32404357
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31625402
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29983035
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.29493693
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28605924
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27444421
60	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27337384
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26257679
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.25472756
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.24056979
64	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.23024098
65	TP53_16413492_ChIP-PET_HCT116_Human	1.22178515
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.20536578
67	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.20375738
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19899022
69	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19644838
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19119355
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17329910
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15352611
73	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.14183200
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12766848
75	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10708780
76	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09026647
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08979834
78	AHR_22903824_ChIP-Seq_MCF-7_Human	1.08423629
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08024161
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07454569
81	KDM2B_26808549_Chip-Seq_REH_Human	1.07422399
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05810834
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.05590607
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05555371
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05555371
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05219180
87	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.04458967
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03756475
89	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03710229
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.02266167
91	DROSHA_22980978_ChIP-Seq_HELA_Human	1.01663019
92	RXR_22108803_ChIP-Seq_LS180_Human	1.00406427
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98615529
94	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.98179864
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97651043
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97404746
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.97357608
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.96579659
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96291901
100	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.96018419

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.19009081
2	MP0002102_abnormal_ear_morphology	2.73588895
3	MP0008057_abnormal_DNA_replication	2.62707350
4	MP0008877_abnormal_DNA_methylation	2.42468304
5	MP0003195_calcinosis	2.34924241
6	MP0003646_muscle_fatigue	2.33129496
7	MP0003787_abnormal_imprinting	2.26784228
8	MP0005551_abnormal_eye_electrophysiolog	2.18962802
9	MP0004145_abnormal_muscle_electrophysio	2.14059163
10	MP0001486_abnormal_startle_reflex	2.06806269
11	MP0003880_abnormal_central_pattern	2.05616811
12	MP0009046_muscle_twitch	2.03528759
13	MP0005646_abnormal_pituitary_gland	2.02745197
14	MP0009745_abnormal_behavioral_response	1.91281433
15	MP0004142_abnormal_muscle_tone	1.91022448
16	MP0001968_abnormal_touch/_nociception	1.87120511
17	MP0005174_abnormal_tail_pigmentation	1.82711662
18	MP0001986_abnormal_taste_sensitivity	1.82299072
19	MP0004130_abnormal_muscle_cell	1.79246267
20	MP0000427_abnormal_hair_cycle	1.77116820
21	MP0002272_abnormal_nervous_system	1.76049544
22	MP0003136_yellow_coat_color	1.75028543
23	MP0004043_abnormal_pH_regulation	1.72337158
24	MP0002009_preneoplasia	1.69703379
25	MP0002638_abnormal_pupillary_reflex	1.69664514
26	MP0005253_abnormal_eye_physiology	1.68636730
27	MP0004215_abnormal_myocardial_fiber	1.66235142
28	MP0001501_abnormal_sleep_pattern	1.65482144
29	MP0003890_abnormal_embryonic-extraembry	1.64475210
30	MP0000631_abnormal_neuroendocrine_gland	1.64339261
31	MP0000778_abnormal_nervous_system	1.61413550
32	MP0001984_abnormal_olfaction	1.60627666
33	MP0003635_abnormal_synaptic_transmissio	1.60295658
34	MP0000383_abnormal_hair_follicle	1.55838675
35	MP0002928_abnormal_bile_duct	1.52874739
36	MP0004742_abnormal_vestibular_system	1.52757049
37	MP0002064_seizures	1.51162919
38	MP0004924_abnormal_behavior	1.49490445
39	MP0005386_behavior/neurological_phenoty	1.49490445
40	MP0005645_abnormal_hypothalamus_physiol	1.47701146
41	MP0002063_abnormal_learning/memory/cond	1.45417129
42	MP0006072_abnormal_retinal_apoptosis	1.44027064
43	MP0002572_abnormal_emotion/affect_behav	1.42699711
44	MP0004484_altered_response_of	1.40115159
45	MP0002067_abnormal_sensory_capabilities	1.37771322
46	MP0005187_abnormal_penis_morphology	1.33919493
47	MP0002837_dystrophic_cardiac_calcinosis	1.21569093
48	MP0004134_abnormal_chest_morphology	1.21269531
49	MP0002735_abnormal_chemical_nociception	1.19023867
50	MP0002557_abnormal_social/conspecific_i	1.16357334
51	MP0002734_abnormal_mechanical_nocicepti	1.13422026
52	MP0002736_abnormal_nociception_after	1.12948563
53	MP0006276_abnormal_autonomic_nervous	1.11893400
54	MP0003121_genomic_imprinting	1.07587071
55	MP0010386_abnormal_urinary_bladder	1.07309777
56	MP0003011_delayed_dark_adaptation	1.07034269
57	MP0002095_abnormal_skin_pigmentation	1.06587297
58	MP0000372_irregular_coat_pigmentation	1.05815149
59	MP0004084_abnormal_cardiac_muscle	1.05510720
60	MP0000955_abnormal_spinal_cord	1.05290455
61	MP0003137_abnormal_impulse_conducting	1.05061321
62	MP0003567_abnormal_fetal_cardiomyocyte	1.04704264
63	MP0002229_neurodegeneration	1.00469499
64	MP0002184_abnormal_innervation	1.00362283
65	MP0005310_abnormal_salivary_gland	0.99749785
66	MP0004147_increased_porphyrin_level	0.99049617
67	MP0008872_abnormal_physiological_respon	0.98535250
68	MP0008961_abnormal_basal_metabolism	0.96750070
69	MP0003252_abnormal_bile_duct	0.95883480
70	MP0001485_abnormal_pinna_reflex	0.95667457
71	MP0002876_abnormal_thyroid_physiology	0.94559749
72	MP0001529_abnormal_vocalization	0.93822229
73	MP0001440_abnormal_grooming_behavior	0.92513616
74	MP0002752_abnormal_somatic_nervous	0.91303799
75	MP0002882_abnormal_neuron_morphology	0.91164842
76	MP0000015_abnormal_ear_pigmentation	0.90507304
77	MP0004085_abnormal_heartbeat	0.90246212
78	MP0001324_abnormal_eye_pigmentation	0.90013847
79	MP0004133_heterotaxia	0.89963801
80	MP0002751_abnormal_autonomic_nervous	0.88318609
81	MP0003122_maternal_imprinting	0.87846114
82	MP0001188_hyperpigmentation	0.87100238
83	MP0005195_abnormal_posterior_eye	0.86579697
84	MP0003045_fibrosis	0.86524460
85	MP0010678_abnormal_skin_adnexa	0.85902385
86	MP0003937_abnormal_limbs/digits/tail_de	0.85761609
87	MP0005167_abnormal_blood-brain_barrier	0.85564415
88	MP0001970_abnormal_pain_threshold	0.85332520
89	MP0002938_white_spotting	0.82952263
90	MP0003632_abnormal_nervous_system	0.82936618
91	MP0003633_abnormal_nervous_system	0.82311486
92	MP0005085_abnormal_gallbladder_physiolo	0.82294241
93	MP0003698_abnormal_male_reproductive	0.79060714
94	MP0004885_abnormal_endolymph	0.78311244
95	MP0008775_abnormal_heart_ventricle	0.77825161
96	MP0005391_vision/eye_phenotype	0.77577500
97	MP0003631_nervous_system_phenotype	0.76137159
98	MP0005423_abnormal_somatic_nervous	0.75909151
99	MP0004270_analgesia	0.75867911
100	MP0001293_anophthalmia	0.75578566

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.26299899
2	Pancreatic cysts (HP:0001737)	3.91696512
3	Chronic hepatic failure (HP:0100626)	3.70169454
4	Nephronophthisis (HP:0000090)	3.61163512
5	Pancreatic fibrosis (HP:0100732)	3.44430664
6	Abnormality of midbrain morphology (HP:0002418)	3.42092622
7	Molar tooth sign on MRI (HP:0002419)	3.42092622
8	Genetic anticipation (HP:0003743)	3.38353118
9	Gaze-evoked nystagmus (HP:0000640)	3.35834045
10	Abnormality of the renal medulla (HP:0100957)	3.31083662
11	True hermaphroditism (HP:0010459)	3.26551279
12	Medial flaring of the eyebrow (HP:0010747)	3.14638420
13	Febrile seizures (HP:0002373)	3.04463562
14	Abnormality of the renal cortex (HP:0011035)	3.04145218
15	Type II lissencephaly (HP:0007260)	2.89191373
16	Progressive cerebellar ataxia (HP:0002073)	2.83163818
17	Broad-based gait (HP:0002136)	2.78885860
18	Stomach cancer (HP:0012126)	2.71455967
19	Congenital stationary night blindness (HP:0007642)	2.66172816
20	Cerebellar dysplasia (HP:0007033)	2.64151926
21	Protruding tongue (HP:0010808)	2.63934566
22	Progressive inability to walk (HP:0002505)	2.58397800
23	Lissencephaly (HP:0001339)	2.54703087
24	Drooling (HP:0002307)	2.53673541
25	Attenuation of retinal blood vessels (HP:0007843)	2.52518029
26	Fair hair (HP:0002286)	2.52436888
27	Gait imbalance (HP:0002141)	2.48762391
28	Inability to walk (HP:0002540)	2.47731918
29	Abnormal biliary tract physiology (HP:0012439)	2.45854103
30	Bile duct proliferation (HP:0001408)	2.45854103
31	Widely spaced teeth (HP:0000687)	2.40797391
32	Excessive salivation (HP:0003781)	2.35039431
33	Renal cortical cysts (HP:0000803)	2.34793804
34	Congenital primary aphakia (HP:0007707)	2.34242205
35	Cystic liver disease (HP:0006706)	2.30124368
36	Large for gestational age (HP:0001520)	2.28586238
37	Genital tract atresia (HP:0001827)	2.26484784
38	Pheochromocytoma (HP:0002666)	2.25473504
39	Nephrogenic diabetes insipidus (HP:0009806)	2.25296823
40	Focal motor seizures (HP:0011153)	2.25017868
41	Absent speech (HP:0001344)	2.20307905
42	Vaginal atresia (HP:0000148)	2.19649685
43	Tubular atrophy (HP:0000092)	2.15065691
44	Focal seizures (HP:0007359)	2.13825149
45	Poor coordination (HP:0002370)	2.11880680
46	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.07921149
47	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.07921149
48	Hypothermia (HP:0002045)	2.06053978
49	Congenital hepatic fibrosis (HP:0002612)	2.03868993
50	Partial agenesis of the corpus callosum (HP:0001338)	2.01867058
51	Chorioretinal atrophy (HP:0000533)	2.00885070
52	Tented upper lip vermilion (HP:0010804)	1.98133596
53	Generalized hypopigmentation of hair (HP:0011358)	1.98045749
54	Clubbing of toes (HP:0100760)	1.96592309
55	Neoplasm of the adrenal cortex (HP:0100641)	1.96022560
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95944128
57	Abnormality of alanine metabolism (HP:0010916)	1.95944128
58	Hyperalaninemia (HP:0003348)	1.95944128
59	Colon cancer (HP:0003003)	1.93612201
60	Decreased central vision (HP:0007663)	1.93251264
61	Glioma (HP:0009733)	1.91318156
62	Atonic seizures (HP:0010819)	1.91124663
63	Neuroendocrine neoplasm (HP:0100634)	1.89476932
64	Birth length less than 3rd percentile (HP:0003561)	1.88548118
65	Furrowed tongue (HP:0000221)	1.88397222
66	Thyroiditis (HP:0100646)	1.88038670
67	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87136297
68	Postaxial foot polydactyly (HP:0001830)	1.86771021
69	Polydipsia (HP:0001959)	1.86120557
70	Abnormal drinking behavior (HP:0030082)	1.86120557
71	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85171845
72	Dialeptic seizures (HP:0011146)	1.84524253
73	Abnormality of the corticospinal tract (HP:0002492)	1.83472323
74	Hemiparesis (HP:0001269)	1.83140535
75	Decreased circulating renin level (HP:0003351)	1.82921259
76	Urinary bladder sphincter dysfunction (HP:0002839)	1.76612363
77	Keratoconus (HP:0000563)	1.76257173
78	Increased corneal curvature (HP:0100692)	1.76257173
79	Clumsiness (HP:0002312)	1.75257508
80	Cupped ear (HP:0000378)	1.75109376
81	Abolished electroretinogram (ERG) (HP:0000550)	1.74530057
82	Abnormality of macular pigmentation (HP:0008002)	1.73480591
83	Thyroid-stimulating hormone excess (HP:0002925)	1.71660565
84	Oligodactyly (hands) (HP:0001180)	1.71187335
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71084358
86	Calf muscle hypertrophy (HP:0008981)	1.70823632
87	Hypoplastic labia majora (HP:0000059)	1.70131586
88	Biliary tract neoplasm (HP:0100574)	1.68258421
89	Specific learning disability (HP:0001328)	1.67968863
90	Astigmatism (HP:0000483)	1.67697761
91	Patellar aplasia (HP:0006443)	1.66921217
92	Epileptic encephalopathy (HP:0200134)	1.65482841
93	Short 4th metacarpal (HP:0010044)	1.65370918
94	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.65370918
95	Abnormality of the labia majora (HP:0012881)	1.64955916
96	Pachygyria (HP:0001302)	1.64916511
97	Postaxial hand polydactyly (HP:0001162)	1.64504216
98	Absent/shortened dynein arms (HP:0200106)	1.63230369
99	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.63230369
100	Absence seizures (HP:0002121)	1.62135281

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.88424588
2	MAP3K4	2.77072152
3	TAOK3	2.53416988
4	CAMKK2	2.51945269
5	BMPR1B	2.37464464
6	ACVR1B	2.22179270
7	WNK3	2.19133641
8	MAPK13	2.09937245
9	CASK	2.00979674
10	ZAK	1.81440599
11	NUAK1	1.73443079
12	ADRBK2	1.72043103
13	MARK1	1.63747348
14	INSRR	1.63162296
15	AKT3	1.61018227
16	NTRK3	1.59491952
17	OBSCN	1.58357910
18	MAP4K2	1.54057410
19	MAP2K7	1.48110266
20	STK38L	1.47203751
21	MKNK2	1.44520952
22	GRK1	1.42732485
23	BRD4	1.42456925
24	SGK2	1.40229412
25	OXSR1	1.36378032
26	FGFR2	1.36143148
27	PINK1	1.35285290
28	DAPK2	1.32486078
29	MAP2K4	1.27907210
30	PAK3	1.27154417
31	BCR	1.22668645
32	TNIK	1.20639116
33	TEC	1.17059183
34	LATS1	1.14002174
35	ERBB3	1.11846257
36	NTRK2	1.10054145
37	STK39	1.07719495
38	PIK3CA	1.06920093
39	BRSK2	1.05849324
40	CAMK1D	1.05451629
41	CAMK1G	1.01741186
42	TXK	0.99046231
43	SGK494	0.95759972
44	SGK223	0.95759972
45	EPHA3	0.90445784
46	WNK4	0.90032993
47	PNCK	0.85815955
48	TNK2	0.81574490
49	CSNK1A1L	0.81310388
50	TLK1	0.79051385
51	CAMKK1	0.77781923
52	CAMK4	0.76482319
53	ITK	0.76474443
54	PRKCE	0.75984840
55	EPHA4	0.75716173
56	NLK	0.74528808
57	ADRBK1	0.74071996
58	CDK3	0.73007084
59	STK11	0.72427593
60	BLK	0.71634689
61	MAP3K7	0.71143647
62	MAP3K6	0.68460057
63	SIK2	0.67314715
64	MAP3K2	0.66615399
65	PTK2B	0.65010049
66	PHKG1	0.62698063
67	PHKG2	0.62698063
68	PRKAA1	0.60432995
69	PRKCG	0.57365054
70	SGK3	0.56437176
71	MKNK1	0.56234986
72	PRKAA2	0.55769694
73	CAMK1	0.55062023
74	TRIM28	0.54036598
75	TRPM7	0.52261411
76	CAMK2A	0.51458589
77	SGK1	0.51201354
78	CSNK1G2	0.50772697
79	CSNK1G1	0.50069499
80	RET	0.49833161
81	KSR1	0.48908078
82	WNK1	0.48009603
83	STK38	0.46462583
84	TGFBR1	0.45790780
85	DYRK1A	0.45328219
86	MELK	0.45064838
87	BTK	0.44636610
88	ERBB2	0.44605034
89	PLK2	0.44270444
90	CCNB1	0.44237945
91	MAP2K6	0.43747081
92	PRKCH	0.43739241
93	SYK	0.43383084
94	PIK3CG	0.43237407
95	FGFR3	0.42141675
96	EIF2AK3	0.41844624
97	PRKCQ	0.41615426
98	CSNK1D	0.40943930
99	STK3	0.39736654
100	DYRK2	0.38573316

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.36594469
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.31824998
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12060695
4	Phototransduction_Homo sapiens_hsa04744	2.06705476
5	Morphine addiction_Homo sapiens_hsa05032	2.06288309
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05173544
7	Taste transduction_Homo sapiens_hsa04742	2.01139754
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.99531986
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97293840
10	Butanoate metabolism_Homo sapiens_hsa00650	1.94861984
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81126310
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.80777316
13	GABAergic synapse_Homo sapiens_hsa04727	1.76939390
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.75280817
15	Circadian entrainment_Homo sapiens_hsa04713	1.71475275
16	ABC transporters_Homo sapiens_hsa02010	1.69254425
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.68926438
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.68855148
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62945668
20	Regulation of autophagy_Homo sapiens_hsa04140	1.58671228
21	Olfactory transduction_Homo sapiens_hsa04740	1.44076184
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40928316
23	Serotonergic synapse_Homo sapiens_hsa04726	1.37527351
24	Cholinergic synapse_Homo sapiens_hsa04725	1.36280399
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35275418
26	Insulin secretion_Homo sapiens_hsa04911	1.31244426
27	Dopaminergic synapse_Homo sapiens_hsa04728	1.24076332
28	Long-term depression_Homo sapiens_hsa04730	1.23123940
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.22649738
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22256283
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.21671669
32	Circadian rhythm_Homo sapiens_hsa04710	1.20048070
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.19306582
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.16774449
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.14601133
36	Renin secretion_Homo sapiens_hsa04924	1.12819402
37	Propanoate metabolism_Homo sapiens_hsa00640	1.11836058
38	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.11215902
39	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.08834416
40	Salivary secretion_Homo sapiens_hsa04970	1.08126232
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.07790810
42	Basal transcription factors_Homo sapiens_hsa03022	1.02958234
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02164921
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.99957700
45	Lysine degradation_Homo sapiens_hsa00310	0.99566557
46	Amphetamine addiction_Homo sapiens_hsa05031	0.99188451
47	Caffeine metabolism_Homo sapiens_hsa00232	0.98865188
48	Type II diabetes mellitus_Homo sapiens_hsa04930	0.86517600
49	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.85843842
50	cAMP signaling pathway_Homo sapiens_hsa04024	0.85267479
51	Homologous recombination_Homo sapiens_hsa03440	0.83470393
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81487894
53	Gastric acid secretion_Homo sapiens_hsa04971	0.80664553
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.80397842
55	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.80181527
56	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.78908299
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78843893
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77965857
59	RNA degradation_Homo sapiens_hsa03018	0.76632670
60	Histidine metabolism_Homo sapiens_hsa00340	0.75105246
61	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.73188478
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73063856
63	FoxO signaling pathway_Homo sapiens_hsa04068	0.70501368
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68082636
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.66659008
66	Choline metabolism in cancer_Homo sapiens_hsa05231	0.66390075
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63755395
68	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.63609693
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.61816050
70	Axon guidance_Homo sapiens_hsa04360	0.60891973
71	Cocaine addiction_Homo sapiens_hsa05030	0.59155313
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.58878918
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.58788180
74	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.57584146
75	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.56735928
76	Peroxisome_Homo sapiens_hsa04146	0.56150065
77	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.54941824
78	Primary immunodeficiency_Homo sapiens_hsa05340	0.54817409
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54150722
80	MAPK signaling pathway_Homo sapiens_hsa04010	0.53465049
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50913222
82	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.50893079
83	Long-term potentiation_Homo sapiens_hsa04720	0.49551434
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.47080523
85	Retinol metabolism_Homo sapiens_hsa00830	0.47077941
86	Asthma_Homo sapiens_hsa05310	0.45237739
87	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45112409
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44883504
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43461374
90	Prolactin signaling pathway_Homo sapiens_hsa04917	0.43374875
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.42984626
92	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.41549646
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.40673692
94	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.40643016
95	Platelet activation_Homo sapiens_hsa04611	0.40507492
96	Pancreatic secretion_Homo sapiens_hsa04972	0.40092600
97	Ras signaling pathway_Homo sapiens_hsa04014	0.39210556
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.38481907
99	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38183278
100	Insulin resistance_Homo sapiens_hsa04931	0.37799742

ZNF780B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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