ZNF783

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.51724039
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.45299456
3positive regulation of gamma-delta T cell activation (GO:0046645)5.24046909
4antigen processing and presentation of endogenous antigen (GO:0019883)5.07498728
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39761649
6negative regulation of cell killing (GO:0031342)4.39761649
7positive regulation of granulocyte differentiation (GO:0030854)4.38037596
8negative thymic T cell selection (GO:0045060)4.33023623
9negative T cell selection (GO:0043383)4.31855508
10positive regulation of histone deacetylation (GO:0031065)4.26718020
11positive regulation of CREB transcription factor activity (GO:0032793)4.15663884
12regulation of gamma-delta T cell activation (GO:0046643)4.11053333
13regulation of gamma-delta T cell differentiation (GO:0045586)4.10862383
14T cell selection (GO:0045058)4.08881341
15histone H3-K36 demethylation (GO:0070544)4.08338326
16positive T cell selection (GO:0043368)4.00645993
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90415097
18thymic T cell selection (GO:0045061)3.88267118
19positive thymic T cell selection (GO:0045059)3.86617712
20tolerance induction (GO:0002507)3.69764167
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.67342701
22positive regulation of natural killer cell differentiation (GO:0032825)3.64972155
23B cell receptor signaling pathway (GO:0050853)3.60083443
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59165504
25activated T cell proliferation (GO:0050798)3.52023368
26NIK/NF-kappaB signaling (GO:0038061)3.51967478
27CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.50558416
28positive regulation of protein deacetylation (GO:0090312)3.48625230
29antigen processing and presentation via MHC class Ib (GO:0002475)3.47879399
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.42465292
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.40536601
32response to interleukin-15 (GO:0070672)3.40249802
33negative regulation of histone acetylation (GO:0035067)3.38241412
34regulation of granulocyte differentiation (GO:0030852)3.38187292
35natural killer cell differentiation (GO:0001779)3.33883307
36leukocyte aggregation (GO:0070486)3.29443812
37negative regulation of erythrocyte differentiation (GO:0045647)3.29298067
38mannose metabolic process (GO:0006013)3.24491697
39regulation of B cell receptor signaling pathway (GO:0050855)3.21173160
40cellular response to interleukin-15 (GO:0071350)3.20485836
41response to muramyl dipeptide (GO:0032495)3.20284686
42positive regulation by symbiont of host defense response (GO:0052509)3.17952572
43modulation by symbiont of host defense response (GO:0052031)3.17952572
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.17952572
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.17952572
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.17952572
47modulation by symbiont of host immune response (GO:0052553)3.17952572
48regulation of histone H3-K27 methylation (GO:0061085)3.15507926
49regulation of B cell differentiation (GO:0045577)3.07948868
50germinal center formation (GO:0002467)3.03071203
51regulation of histone deacetylation (GO:0031063)3.01806027
52histone H3 deacetylation (GO:0070932)3.00193064
53Peyers patch development (GO:0048541)3.00049896
54mucosal-associated lymphoid tissue development (GO:0048537)3.00049896
55T cell migration (GO:0072678)2.97253157
56positive regulation of antigen processing and presentation (GO:0002579)2.93539415
57negative regulation of cAMP-mediated signaling (GO:0043951)2.90255368
58negative regulation of lymphocyte mediated immunity (GO:0002707)2.87979839
59histone H3-K9 modification (GO:0061647)2.86926821
60histone H4 deacetylation (GO:0070933)2.82169478
61negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.80814788
62positive regulation of B cell differentiation (GO:0045579)2.79467413
63T cell homeostasis (GO:0043029)2.79397852
64regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77887357
65negative regulation of phagocytosis (GO:0050765)2.74036519
66negative regulation of T cell mediated immunity (GO:0002710)2.72701328
67regulation of defense response to virus by host (GO:0050691)2.72459036
68regulation of interleukin-2 biosynthetic process (GO:0045076)2.71337843
69regulation of alpha-beta T cell proliferation (GO:0046640)2.70911740
70antigen receptor-mediated signaling pathway (GO:0050851)2.69754200
71negative regulation of cell size (GO:0045792)2.69002436
72histone H3-K9 methylation (GO:0051567)2.67605716
73regulation of interferon-beta biosynthetic process (GO:0045357)2.67597159
74peptidyl-tyrosine autophosphorylation (GO:0038083)2.65845216
75negative regulation of interleukin-1 beta production (GO:0032691)2.63248178
76negative regulation of peptidyl-lysine acetylation (GO:2000757)2.62565842
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.61373489
78regulation of natural killer cell mediated immunity (GO:0002715)2.61373489
79detection of bacterium (GO:0016045)2.59464463
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58834254
81histone H3-K4 trimethylation (GO:0080182)2.55880329
82snRNA processing (GO:0016180)2.55825204
83snRNA metabolic process (GO:0016073)2.54926552
84response to type I interferon (GO:0034340)2.54541121
85lymphocyte homeostasis (GO:0002260)2.52708325
86negative regulation of interleukin-12 production (GO:0032695)2.52510671
87negative regulation of leukocyte mediated immunity (GO:0002704)2.52174436
88regulation of natural killer cell differentiation (GO:0032823)2.51793563
89negative regulation of interleukin-6 production (GO:0032715)2.51511561
90regulation of antigen processing and presentation (GO:0002577)2.50598302
91mitochondrion distribution (GO:0048311)2.49957734
92negative regulation of interleukin-1 production (GO:0032692)2.47017176
93negative regulation of viral release from host cell (GO:1902187)2.47007838
94B cell homeostasis (GO:0001782)2.44952384
95Rap protein signal transduction (GO:0032486)2.44342855
96cellular response to type I interferon (GO:0071357)2.43530568
97type I interferon signaling pathway (GO:0060337)2.43530568
98negative regulation of protein oligomerization (GO:0032460)2.43303372
99T cell receptor signaling pathway (GO:0050852)2.42724732
100detection of other organism (GO:0098543)2.42543814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.36330185
2MYC_22102868_ChIP-Seq_BL_Human4.23961489
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.09861514
4VDR_21846776_ChIP-Seq_THP-1_Human3.29707791
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.85499061
6KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.72490797
7KDM2B_26808549_Chip-Seq_DND41_Human2.65966579
8KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.62053455
9MAF_26560356_Chip-Seq_TH1_Human2.61595406
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.58466374
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53417415
12RUNX_20019798_ChIP-Seq_JUKART_Human2.50997707
13UTX_26944678_Chip-Seq_JUKART_Human2.50050925
14TCF7_22412390_ChIP-Seq_EML_Mouse2.49876971
15MAF_26560356_Chip-Seq_TH2_Human2.41086830
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.38381614
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29489583
18VDR_24763502_ChIP-Seq_THP-1_Human2.28333481
19MYB_26560356_Chip-Seq_TH2_Human2.15912556
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.09733838
21MYB_26560356_Chip-Seq_TH1_Human2.08731682
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.05507058
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04597773
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99760858
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98972194
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98029975
27SCL_19346495_ChIP-Seq_HPC-7_Human1.93700953
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92371375
29LXR_22292898_ChIP-Seq_THP-1_Human1.92088580
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85779994
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.85415976
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.85094075
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85093207
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83236912
35CIITA_25753668_ChIP-Seq_RAJI_Human1.82916842
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.78561307
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76495626
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.71087189
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.68928191
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68242725
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67120696
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66389260
43P68_20966046_ChIP-Seq_HELA_Human1.63184060
44SPI1_23547873_ChIP-Seq_NB4_Human1.62288720
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.61628691
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.58555869
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55924486
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52255767
49BCOR_27268052_Chip-Seq_Bcells_Human1.51894769
50GATA3_27048872_Chip-Seq_THYMUS_Human1.48348447
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46796117
52SPI1_23127762_ChIP-Seq_K562_Human1.46034271
53BCL6_27268052_Chip-Seq_Bcells_Human1.44922106
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43539190
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41384139
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35028105
57DROSHA_22980978_ChIP-Seq_HELA_Human1.34591523
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33892370
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.33600529
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.32707432
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32410605
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32060730
63GATA1_22025678_ChIP-Seq_K562_Human1.31043031
64SMC4_20622854_ChIP-Seq_HELA_Human1.30088950
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.29690507
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.27586917
67KDM5A_27292631_Chip-Seq_BREAST_Human1.26491607
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22257303
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22093478
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21882686
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17715599
72RACK7_27058665_Chip-Seq_MCF-7_Human1.17216211
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14935609
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14644069
75CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14532644
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14082874
77RARB_24833708_ChIP-Seq_LIVER_Mouse1.13687335
78PHF8_20622854_ChIP-Seq_HELA_Human1.13686305
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13463498
80GATA3_26560356_Chip-Seq_TH2_Human1.12993149
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11578568
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11331364
83NCOR1_26117541_ChIP-Seq_K562_Human1.08717106
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08394556
85VDR_24787735_ChIP-Seq_THP-1_Human1.07302337
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.07152181
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06630303
88KDM2B_26808549_Chip-Seq_K562_Human1.06273942
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03707118
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01780601
91CREB1_26743006_Chip-Seq_LNCaP_Human1.01102245
92OCT4_19829295_ChIP-Seq_ESCs_Human1.00605482
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99956208
94* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98869784
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98374457
96E2F1_20622854_ChIP-Seq_HELA_Human0.98350965
97SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.98315732
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98312694
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98084389
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97865060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.74966253
2MP0003172_abnormal_lysosome_physiology3.14085932
3MP0003436_decreased_susceptibility_to3.12018438
4MP0001800_abnormal_humoral_immune2.99734427
5MP0000685_abnormal_immune_system2.90228122
6MP0005671_abnormal_response_to2.78272211
7MP0001835_abnormal_antigen_presentation2.59056673
8MP0001873_stomach_inflammation2.55978233
9MP0005387_immune_system_phenotype2.48282220
10MP0001790_abnormal_immune_system2.48282220
11MP0002396_abnormal_hematopoietic_system2.45845897
12MP0004381_abnormal_hair_follicle2.45677152
13MP0002723_abnormal_immune_serum2.44914591
14MP0009333_abnormal_splenocyte_physiolog2.44572328
15MP0002420_abnormal_adaptive_immunity2.34332124
16MP0000703_abnormal_thymus_morphology2.31893222
17MP0001819_abnormal_immune_cell2.31233704
18MP0002452_abnormal_antigen_presenting2.29782019
19MP0005000_abnormal_immune_tolerance2.26834539
20MP0005076_abnormal_cell_differentiation2.25551210
21MP0001348_abnormal_lacrimal_gland2.20626387
22MP0002398_abnormal_bone_marrow2.17529635
23MP0005310_abnormal_salivary_gland2.15762914
24MP0003303_peritoneal_inflammation2.14941290
25MP0005025_abnormal_response_to2.07113086
26MP0002419_abnormal_innate_immunity2.04102794
27MP0000716_abnormal_immune_system1.95765437
28MP0001849_ear_inflammation1.93643021
29MP0009278_abnormal_bone_marrow1.85103295
30MP0000689_abnormal_spleen_morphology1.84064351
31MP0002722_abnormal_immune_system1.79901693
32MP0002405_respiratory_system_inflammati1.71213493
33MP0004808_abnormal_hematopoietic_stem1.70685881
34MP0009785_altered_susceptibility_to1.68038587
35MP0002429_abnormal_blood_cell1.62013842
36MP0003724_increased_susceptibility_to1.60653719
37MP0002933_joint_inflammation1.51186136
38MP0008260_abnormal_autophagy1.48266563
39MP0002254_reproductive_system_inflammat1.44948578
40MP0002009_preneoplasia1.42631774
41MP0005075_abnormal_melanosome_morpholog1.39406559
42MP0005451_abnormal_body_composition1.39332460
43MP0003183_abnormal_peptide_metabolism1.36979203
44MP0008877_abnormal_DNA_methylation1.35741240
45MP0003943_abnormal_hepatobiliary_system1.35342488
46MP0010155_abnormal_intestine_physiology1.31826851
47MP0009840_abnormal_foam_cell1.30008926
48MP0000465_gastrointestinal_hemorrhage1.29923402
49MP0000371_diluted_coat_color1.29352450
50MP0001545_abnormal_hematopoietic_system1.28157095
51MP0005397_hematopoietic_system_phenotyp1.28157095
52MP0000015_abnormal_ear_pigmentation1.27660787
53MP0002148_abnormal_hypersensitivity_rea1.25540524
54MP0006082_CNS_inflammation1.20623568
55MP0008961_abnormal_basal_metabolism1.16445877
56MP0003045_fibrosis1.14726651
57MP0003866_abnormal_defecation1.13025797
58MP0004947_skin_inflammation1.12875936
59MP0003300_gastrointestinal_ulcer1.10590243
60MP0001845_abnormal_inflammatory_respons1.08300820
61MP0001533_abnormal_skeleton_physiology1.04935838
62MP0002693_abnormal_pancreas_physiology1.04431609
63MP0001851_eye_inflammation0.99889917
64MP0005058_abnormal_lysosome_morphology0.97676919
65MP0002970_abnormal_white_adipose0.97527929
66MP0005167_abnormal_blood-brain_barrier0.93404919
67MP0008995_early_reproductive_senescence0.89705350
68MP0001663_abnormal_digestive_system0.89635702
69MP0005464_abnormal_platelet_physiology0.88941945
70MP0008469_abnormal_protein_level0.88261790
71MP0002168_other_aberrant_phenotype0.87991807
72MP0004185_abnormal_adipocyte_glucose0.87862694
73MP0000733_abnormal_muscle_development0.85291875
74MP0003828_pulmonary_edema0.85023029
75MP0002166_altered_tumor_susceptibility0.82648831
76MP0002075_abnormal_coat/hair_pigmentati0.82429256
77MP0000538_abnormal_urinary_bladder0.81787239
78MP0005220_abnormal_exocrine_pancreas0.78091361
79MP0002998_abnormal_bone_remodeling0.77618160
80MP0005367_renal/urinary_system_phenotyp0.77505117
81MP0000516_abnormal_urinary_system0.77505117
82MP0003221_abnormal_cardiomyocyte_apopto0.74908236
83MP0006035_abnormal_mitochondrial_morpho0.72007773
84MP0001661_extended_life_span0.71198539
85MP0002019_abnormal_tumor_incidence0.70408711
86MP0001853_heart_inflammation0.70229259
87MP0000767_abnormal_smooth_muscle0.66065112
88MP0009764_decreased_sensitivity_to0.65918146
89MP0002132_abnormal_respiratory_system0.64813191
90MP0000470_abnormal_stomach_morphology0.64635585
91MP0000490_abnormal_crypts_of0.63530781
92MP0003656_abnormal_erythrocyte_physiolo0.59628183
93MP0003329_amyloid_beta_deposits0.59047322
94MP0005174_abnormal_tail_pigmentation0.58800736
95MP0005448_abnormal_energy_balance0.58033313
96MP0005360_urolithiasis0.56909473
97MP0000249_abnormal_blood_vessel0.55145675
98MP0000604_amyloidosis0.53739158
99MP0005381_digestive/alimentary_phenotyp0.53628740
100MP0010307_abnormal_tumor_latency0.52513263

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)4.07971147
2Recurrent fungal infections (HP:0002841)3.80006567
3Panhypogammaglobulinemia (HP:0003139)3.68818792
4Recurrent cutaneous fungal infections (HP:0011370)3.57356250
5Chronic mucocutaneous candidiasis (HP:0002728)3.57356250
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.52877222
7Agammaglobulinemia (HP:0004432)3.51936741
8Eczematoid dermatitis (HP:0000976)3.30606395
9J-shaped sella turcica (HP:0002680)3.08409550
10Severe combined immunodeficiency (HP:0004430)3.07951656
11Thoracic kyphosis (HP:0002942)3.01833837
12Long foot (HP:0001833)2.93249045
13Recurrent viral infections (HP:0004429)2.85806560
14Pustule (HP:0200039)2.84943520
15Stomatitis (HP:0010280)2.84709742
16T lymphocytopenia (HP:0005403)2.76499263
17Meningitis (HP:0001287)2.74866383
18Recurrent bacterial skin infections (HP:0005406)2.72119793
19Hyperventilation (HP:0002883)2.68890332
20Urethral obstruction (HP:0000796)2.56808885
21Papilloma (HP:0012740)2.56262216
22Verrucae (HP:0200043)2.56262216
23Elevated erythrocyte sedimentation rate (HP:0003565)2.52893052
24Recurrent skin infections (HP:0001581)2.49343568
25Abnormality of T cell number (HP:0011839)2.48234699
26Anal stenosis (HP:0002025)2.48104328
27Recurrent abscess formation (HP:0002722)2.47690468
28Abnormality of the fingertips (HP:0001211)2.46283232
29Abnormality of the thoracic spine (HP:0100711)2.45560376
30Dysostosis multiplex (HP:0000943)2.44692169
31Abnormality of T cells (HP:0002843)2.43842744
32Increased IgE level (HP:0003212)2.40460599
33Tented upper lip vermilion (HP:0010804)2.30441985
34Cellulitis (HP:0100658)2.29240788
35Abnormality of the lumbar spine (HP:0100712)2.28798977
36Chest pain (HP:0100749)2.27922550
37Mediastinal lymphadenopathy (HP:0100721)2.27334360
38Lymphopenia (HP:0001888)2.24461650
39Abnormality of T cell physiology (HP:0011840)2.21643339
40Clumsiness (HP:0002312)2.21353297
41Enlarged penis (HP:0000040)2.21264812
42Abnormality of glycolipid metabolism (HP:0010969)2.20482392
43Abnormality of liposaccharide metabolism (HP:0010968)2.20482392
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.20482392
45Lymphangioma (HP:0100764)2.19749065
46Encephalitis (HP:0002383)2.18984967
47Hypoplasia of the thymus (HP:0000778)2.18400027
48Birth length less than 3rd percentile (HP:0003561)2.18126424
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.16799577
50Combined immunodeficiency (HP:0005387)2.16460464
51Myositis (HP:0100614)2.15587008
52Broad face (HP:0000283)2.11509236
53Increased cerebral lipofuscin (HP:0011813)2.11150954
54Colitis (HP:0002583)2.04764686
55Germ cell neoplasia (HP:0100728)2.03640731
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.01386810
57Partial agenesis of the corpus callosum (HP:0001338)2.00031221
58Abnormality of polysaccharide metabolism (HP:0011012)1.99403817
59Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99403817
60Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99403817
61Granulocytopenia (HP:0001913)1.98148534
62Protruding tongue (HP:0010808)1.96446719
63Hemoptysis (HP:0002105)1.95565965
64Gastrointestinal inflammation (HP:0004386)1.95245328
65Gingivitis (HP:0000230)1.93854850
66Elfin facies (HP:0004428)1.91981155
67Mesangial abnormality (HP:0001966)1.90620994
68Neoplasm of the adrenal cortex (HP:0100641)1.89920759
69Viral hepatitis (HP:0006562)1.88195343
70Breast hypoplasia (HP:0003187)1.87036729
71Neurodegeneration (HP:0002180)1.84298967
72Inflammation of the large intestine (HP:0002037)1.83762974
73Amelogenesis imperfecta (HP:0000705)1.82325621
74Hyperacusis (HP:0010780)1.81060510
75Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80972140
76Abnormality of macrophages (HP:0004311)1.80742272
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80700938
78Widely spaced teeth (HP:0000687)1.80696962
79Hypochromic anemia (HP:0001931)1.80673774
80Fatigue (HP:0012378)1.78611842
81Thyroiditis (HP:0100646)1.77984312
82Microtia (HP:0008551)1.76469704
83Acute lymphatic leukemia (HP:0006721)1.76241633
84Leukocytosis (HP:0001974)1.75983145
85Recurrent pneumonia (HP:0006532)1.74952158
86Abnormality of eosinophils (HP:0001879)1.74439530
87IgG deficiency (HP:0004315)1.74370426
88Vasculitis (HP:0002633)1.74111142
89Sepsis (HP:0100806)1.72977299
90Mucopolysacchariduria (HP:0008155)1.72404378
91Urinary glycosaminoglycan excretion (HP:0003541)1.72404378
92Neoplasm of the heart (HP:0100544)1.70400298
93Concave nail (HP:0001598)1.69624845
94Restrictive lung disease (HP:0002091)1.69580421
95Basal cell carcinoma (HP:0002671)1.69274086
96Orchitis (HP:0100796)1.67716557
97Optic neuritis (HP:0100653)1.67691152
98Retrobulbar optic neuritis (HP:0100654)1.67691152
99Hamartoma of the eye (HP:0010568)1.66588841
100Stridor (HP:0010307)1.65603979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.07812182
2MAP4K13.80969368
3TRIB33.78424321
4SIK22.79922937
5SIK32.65329851
6TYK22.40630295
7TNK22.32466521
8SMG12.04957976
9FES2.00609503
10TXK1.99590230
11PRPF4B1.99043015
12MAP3K101.92676053
13ACVR1B1.81192745
14ZAP701.76982668
15SIK11.76403491
16IKBKE1.62544157
17BLK1.60183728
18IRAK41.57790710
19EEF2K1.55510054
20MAP3K141.54774828
21CAMKK11.50990744
22BTK1.49556477
23GRK61.46794183
24PRKD21.42584910
25HIPK21.41760408
26ITK1.38820688
27MAP3K71.37793977
28IKBKB1.36517333
29RIPK41.33433460
30JAK31.32983258
31ERN11.28415596
32HCK1.27113078
33MAPK121.25812317
34EPHB11.23133474
35MARK21.20750883
36NME11.20632048
37SYK1.12568172
38PKN21.11898759
39TBK11.07894923
40MAP3K131.06918013
41LYN1.05934607
42MAP2K31.03812122
43CSF1R1.02101759
44MAPK131.01909953
45LCK1.01535316
46PASK1.01488667
47ICK1.00534071
48CSK0.94436175
49STK110.94084877
50KIT0.92456079
51MARK30.91950037
52FGR0.87060885
53PRKD30.86976931
54PTK2B0.81673689
55TAOK10.80598525
56MELK0.79270476
57CHUK0.79001450
58JAK10.77890780
59MAPK110.77473565
60CDK40.77401313
61FGFR40.75505038
62FGFR30.73085629
63PDK10.72656287
64MAPK70.72447945
65CDC42BPA0.71836876
66PTK60.70858988
67BRD40.70502735
68DAPK20.68600438
69TAOK30.68024335
70MAP3K10.67253666
71IRAK30.66627316
72IRAK20.63175062
73RPS6KA60.62170714
74IRAK10.60879173
75TGFBR10.60798313
76JAK20.60450126
77MAP2K60.59759375
78PIM10.58948037
79CDK120.58724913
80FRK0.55943392
81BMPR1B0.55885797
82CAMKK20.52494953
83MAPK80.50158707
84RPS6KC10.48776107
85RPS6KL10.48776107
86MTOR0.47471020
87TEC0.47352221
88CAMK40.47034352
89PDPK10.44525303
90EPHA30.43510489
91PKN10.43383243
92MAP3K30.42253153
93KSR20.41430623
94FER0.37691165
95NLK0.36912111
96TYRO30.36651904
97BMX0.35945178
98PRKCH0.35554359
99PRKD10.33839527
100MAP2K10.33734089

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.19298404
2B cell receptor signaling pathway_Homo sapiens_hsa046622.21042624
3T cell receptor signaling pathway_Homo sapiens_hsa046602.05406877
4Other glycan degradation_Homo sapiens_hsa005112.02642102
5Acute myeloid leukemia_Homo sapiens_hsa052212.01119878
6Osteoclast differentiation_Homo sapiens_hsa043801.98745114
7Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.83777888
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74757598
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68992440
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63276339
11Chronic myeloid leukemia_Homo sapiens_hsa052201.60634446
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.59635556
13mTOR signaling pathway_Homo sapiens_hsa041501.55282500
14Measles_Homo sapiens_hsa051621.54249278
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51681380
16Notch signaling pathway_Homo sapiens_hsa043301.48826440
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.47933096
18VEGF signaling pathway_Homo sapiens_hsa043701.40516603
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39993814
20Graft-versus-host disease_Homo sapiens_hsa053321.34721472
21Allograft rejection_Homo sapiens_hsa053301.34585985
22Non-small cell lung cancer_Homo sapiens_hsa052231.34533105
23Autoimmune thyroid disease_Homo sapiens_hsa053201.33548795
24Hepatitis B_Homo sapiens_hsa051611.29478670
25Phospholipase D signaling pathway_Homo sapiens_hsa040721.27755543
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.22837813
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21359659
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20933874
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.19420835
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19298419
31Herpes simplex infection_Homo sapiens_hsa051681.19270895
32TNF signaling pathway_Homo sapiens_hsa046681.18155744
33Leishmaniasis_Homo sapiens_hsa051401.17562677
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17012893
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.16677983
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16189178
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.15795373
38Non-homologous end-joining_Homo sapiens_hsa034501.14728767
39Influenza A_Homo sapiens_hsa051641.14556959
40ABC transporters_Homo sapiens_hsa020101.09838229
41Inositol phosphate metabolism_Homo sapiens_hsa005621.08156441
42Chemokine signaling pathway_Homo sapiens_hsa040621.04890172
43Tuberculosis_Homo sapiens_hsa051521.04268497
44Hematopoietic cell lineage_Homo sapiens_hsa046401.01047879
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98738897
46Platelet activation_Homo sapiens_hsa046110.98515253
47Insulin resistance_Homo sapiens_hsa049310.97829913
48FoxO signaling pathway_Homo sapiens_hsa040680.96298874
49Lysine degradation_Homo sapiens_hsa003100.94779224
50Colorectal cancer_Homo sapiens_hsa052100.94622459
51Pancreatic cancer_Homo sapiens_hsa052120.92468870
52Choline metabolism in cancer_Homo sapiens_hsa052310.91613716
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91541249
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90149474
55Toxoplasmosis_Homo sapiens_hsa051450.89688161
56Antigen processing and presentation_Homo sapiens_hsa046120.85573014
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85534322
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.85530310
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85191804
60Type I diabetes mellitus_Homo sapiens_hsa049400.84625272
61Renal cell carcinoma_Homo sapiens_hsa052110.84291844
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82950315
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82664946
64Epstein-Barr virus infection_Homo sapiens_hsa051690.82624377
65Apoptosis_Homo sapiens_hsa042100.82060106
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.80265000
67Hepatitis C_Homo sapiens_hsa051600.79990309
68Endometrial cancer_Homo sapiens_hsa052130.79626756
69MAPK signaling pathway_Homo sapiens_hsa040100.79104817
70Prolactin signaling pathway_Homo sapiens_hsa049170.78873248
71Lysosome_Homo sapiens_hsa041420.78831491
72Viral myocarditis_Homo sapiens_hsa054160.77671130
73HTLV-I infection_Homo sapiens_hsa051660.77623413
74Viral carcinogenesis_Homo sapiens_hsa052030.77067177
75Regulation of autophagy_Homo sapiens_hsa041400.75908126
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69686116
77GnRH signaling pathway_Homo sapiens_hsa049120.69004602
78Type II diabetes mellitus_Homo sapiens_hsa049300.66775590
79Staphylococcus aureus infection_Homo sapiens_hsa051500.65268710
80Ras signaling pathway_Homo sapiens_hsa040140.65118446
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64776360
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64232409
83Legionellosis_Homo sapiens_hsa051340.64202894
84Malaria_Homo sapiens_hsa051440.64082286
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63273820
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.63198903
87Dorso-ventral axis formation_Homo sapiens_hsa043200.61604565
88Bladder cancer_Homo sapiens_hsa052190.61500767
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61451279
90mRNA surveillance pathway_Homo sapiens_hsa030150.61110878
91HIF-1 signaling pathway_Homo sapiens_hsa040660.60615882
92Insulin signaling pathway_Homo sapiens_hsa049100.60549931
93Estrogen signaling pathway_Homo sapiens_hsa049150.60144143
94ErbB signaling pathway_Homo sapiens_hsa040120.59851550
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57028193
96Glioma_Homo sapiens_hsa052140.56829130
97Prostate cancer_Homo sapiens_hsa052150.55777269
98Rap1 signaling pathway_Homo sapiens_hsa040150.54434405
99Shigellosis_Homo sapiens_hsa051310.53561536
100MicroRNAs in cancer_Homo sapiens_hsa052060.51228614

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