ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	creatine metabolic process (GO:0006600)	5.68507823
2	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	5.54447178
3	amyloid precursor protein catabolic process (GO:0042987)	5.36416874
4	muscle cell fate commitment (GO:0042693)	5.23807046
5	actin-myosin filament sliding (GO:0033275)	5.14101529
6	muscle filament sliding (GO:0030049)	5.14101529
7	regulation of skeletal muscle contraction (GO:0014819)	5.00822105
8	skeletal muscle contraction (GO:0003009)	4.87428070
9	sarcoplasmic reticulum calcium ion transport (GO:0070296)	4.86170810
10	tooth mineralization (GO:0034505)	4.82240973
11	muscle organ morphogenesis (GO:0048644)	4.73525424
12	apoptotic process involved in morphogenesis (GO:0060561)	4.51432545
13	negative regulation of erythrocyte differentiation (GO:0045647)	4.39293079
14	skeletal muscle fiber development (GO:0048741)	4.29300470
15	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	4.24503605
16	viral transcription (GO:0019083)	4.09088910
17	amyloid precursor protein metabolic process (GO:0042982)	3.97753697
18	positive regulation of myotube differentiation (GO:0010831)	3.92535161
19	mannose metabolic process (GO:0006013)	3.90347699
20	actin-mediated cell contraction (GO:0070252)	3.82437858
21	3-UTR-mediated mRNA stabilization (GO:0070935)	3.67064782
22	ribosomal small subunit biogenesis (GO:0042274)	3.61024454
23	translational termination (GO:0006415)	3.60325184
24	myotube cell development (GO:0014904)	3.37067357
25	myofibril assembly (GO:0030239)	3.33670548
26	sulfur amino acid catabolic process (GO:0000098)	3.30757306
27	response to peptidoglycan (GO:0032494)	3.29057346
28	sarcomere organization (GO:0045214)	3.26526131
29	apoptotic process involved in development (GO:1902742)	3.25257522
30	striated muscle contraction (GO:0006941)	3.24912164
31	pentose metabolic process (GO:0019321)	3.19227618
32	activation of MAPKKK activity (GO:0000185)	3.08903281
33	adenosine receptor signaling pathway (GO:0001973)	3.07333604
34	proline biosynthetic process (GO:0006561)	3.07105707
35	response to muscle activity (GO:0014850)	3.06371728
36	translational elongation (GO:0006414)	3.03999031
37	embryonic viscerocranium morphogenesis (GO:0048703)	3.03215970
38	regulation of chromatin binding (GO:0035561)	3.02314323
39	actin filament-based movement (GO:0030048)	2.99340450
40	respiratory tube development (GO:0030323)	2.97209932
41	viral life cycle (GO:0019058)	2.96638784
42	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.94991740
43	oxidative phosphorylation (GO:0006119)	2.92955262
44	membrane protein intracellular domain proteolysis (GO:0031293)	2.92605964
45	positive regulation of histone deacetylation (GO:0031065)	2.91999555
46	retinoic acid receptor signaling pathway (GO:0048384)	2.83943084
47	negative regulation of viral release from host cell (GO:1902187)	2.83905243
48	outer ear morphogenesis (GO:0042473)	2.83602328
49	NADH metabolic process (GO:0006734)	2.83371701
50	respiratory system process (GO:0003016)	2.81216185
51	regulation of interferon-beta biosynthetic process (GO:0045357)	2.78316646
52	cranial nerve morphogenesis (GO:0021602)	2.77411912
53	cardiac muscle contraction (GO:0060048)	2.77105754
54	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.75949203
55	coronary vasculature morphogenesis (GO:0060977)	2.75075920
56	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.69136247
57	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.68249143
58	cardiac myofibril assembly (GO:0055003)	2.67518099
59	lymph vessel development (GO:0001945)	2.65617369
60	response to inactivity (GO:0014854)	2.64712184
61	peptidyl-glutamic acid carboxylation (GO:0017187)	2.63571055
62	protein carboxylation (GO:0018214)	2.63571055
63	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.61370405
64	outflow tract septum morphogenesis (GO:0003148)	2.60947403
65	positive regulation of triglyceride metabolic process (GO:0090208)	2.60505088
66	positive regulation of lipoprotein lipase activity (GO:0051006)	2.60014308
67	positive regulation of triglyceride lipase activity (GO:0061365)	2.60014308
68	proline metabolic process (GO:0006560)	2.59836061
69	skeletal muscle adaptation (GO:0043501)	2.58627847
70	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.58205738
71	NIK/NF-kappaB signaling (GO:0038061)	2.58189432
72	cellular protein complex disassembly (GO:0043624)	2.58050463
73	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.57787437
74	modulation by symbiont of host cellular process (GO:0044068)	2.57132105
75	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.57063443
76	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.55234923
77	negative regulation of cell size (GO:0045792)	2.52491708
78	regulation of early endosome to late endosome transport (GO:2000641)	2.52011878
79	glycogen catabolic process (GO:0005980)	2.50694030
80	modulation by virus of host process (GO:0019054)	2.48834345
81	lung morphogenesis (GO:0060425)	2.48246100
82	cellular response to virus (GO:0098586)	2.48123506
83	2-oxoglutarate metabolic process (GO:0006103)	2.46140485
84	gluconeogenesis (GO:0006094)	2.45571937
85	regulation of fatty acid biosynthetic process (GO:0042304)	2.45323352
86	anatomical structure regression (GO:0060033)	2.44617237
87	positive regulation of T cell apoptotic process (GO:0070234)	2.44034684
88	positive regulation of protein oligomerization (GO:0032461)	2.43403819
89	skeletal muscle cell differentiation (GO:0035914)	2.42540720
90	nucleotide salvage (GO:0043173)	2.41816906
91	negative regulation of cAMP-mediated signaling (GO:0043951)	2.40734843
92	protein insertion into membrane (GO:0051205)	2.39606309
93	pinocytosis (GO:0006907)	2.38985648
94	glucan catabolic process (GO:0009251)	2.38748611
95	negative regulation of toll-like receptor signaling pathway (GO:0034122)	2.38165682
96	muscle fiber development (GO:0048747)	2.38163821
97	focal adhesion assembly (GO:0048041)	2.37378891
98	cell-substrate adherens junction assembly (GO:0007045)	2.37378891
99	positive regulation of protein kinase C signaling (GO:0090037)	2.36624516
100	regulation of fatty acid beta-oxidation (GO:0031998)	2.36431391

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.63290634
2	VDR_21846776_ChIP-Seq_THP-1_Human	3.57851672
3	LXR_22292898_ChIP-Seq_THP-1_Human	3.16182334
4	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.87968405
5	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.59461271
6	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.45928831
7	MYC_22102868_ChIP-Seq_BL_Human	2.38808481
8	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.27593835
9	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.18900908
10	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.13786241
11	KDM2B_26808549_Chip-Seq_DND41_Human	2.13438602
12	RACK7_27058665_Chip-Seq_MCF-7_Human	2.13316354
13	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.06345339
14	P68_20966046_ChIP-Seq_HELA_Human	2.00103172
15	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.96110895
16	TCF7_22412390_ChIP-Seq_EML_Mouse	1.95288040
17	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.92382261
18	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.89050495
19	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.86558794
20	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.85170163
21	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.84643077
22	KDM2B_26808549_Chip-Seq_K562_Human	1.78644069
23	VDR_24763502_ChIP-Seq_THP-1_Human	1.77339974
24	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.72432188
25	MAF_26560356_Chip-Seq_TH2_Human	1.68925868
26	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.66449000
27	* MAF_26560356_Chip-Seq_TH1_Human	1.65675614
28	CTCF_27219007_Chip-Seq_Bcells_Human	1.64346714
29	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.63495168
30	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.61751038
31	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.59912598
32	CREB1_26743006_Chip-Seq_LNCaP_Human	1.58680025
33	BCL6_27268052_Chip-Seq_Bcells_Human	1.57174401
34	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.56667131
35	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.55935208
36	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.54742132
37	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.53831398
38	BCOR_27268052_Chip-Seq_Bcells_Human	1.53361719
39	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.53263912
40	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.50636088
41	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.46693370
42	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.46542167
43	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.46155952
44	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.45896500
45	* KDM2B_26808549_Chip-Seq_JURKAT_Human	1.44339892
46	CTCF_21964334_Chip-Seq_Bcells_Human	1.44268397
47	SMC4_20622854_ChIP-Seq_HELA_Human	1.43816241
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.43515490
49	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.43097204
50	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.41528439
51	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.41051819
52	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.39390785
53	XRN2_22483619_ChIP-Seq_HELA_Human	1.35704359
54	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.35222239
55	SA1_27219007_Chip-Seq_Bcells_Human	1.34612801
56	ZNF263_19887448_ChIP-Seq_K562_Human	1.33387107
57	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.31629828
58	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.30772970
59	* UTX_26944678_Chip-Seq_JUKART_Human	1.29006302
60	NCOR1_26117541_ChIP-Seq_K562_Human	1.28231812
61	E2F1_20622854_ChIP-Seq_HELA_Human	1.26675506
62	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.26570006
63	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.25639385
64	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.24977318
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.24199801
66	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.20260017
67	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.19575306
68	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.18726189
69	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.18152220
70	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.17243175
71	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.15971398
72	PHF8_20622854_ChIP-Seq_HELA_Human	1.15056223
73	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.14190054
74	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.13075516
75	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.13014624
76	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.12986972
77	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.12867796
78	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.11916829
79	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.11118722
80	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.10365963
81	ATF3_27146783_Chip-Seq_COLON_Human	1.10125553
82	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09875162
83	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.09610692
84	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.09464342
85	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.08762582
86	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.08580853
87	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.08459578
88	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.07790856
89	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.07147223
90	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.05691720
91	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.04688729
92	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.02995472
93	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.02839228
94	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.02268849
95	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.01276094
96	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.01140865
97	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.00191804
98	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.00176981
99	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.00091093
100	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.99918388

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000751_myopathy	3.89017628
2	MP0010030_abnormal_orbit_morphology	3.78368646
3	MP0005451_abnormal_body_composition	3.73574846
4	MP0009840_abnormal_foam_cell	3.43252978
5	MP0003646_muscle_fatigue	3.35936230
6	MP0004145_abnormal_muscle_electrophysio	3.07213818
7	MP0009278_abnormal_bone_marrow	2.97737112
8	MP0005058_abnormal_lysosome_morphology	2.91443234
9	MP0000750_abnormal_muscle_regeneration	2.79989934
10	MP0003303_peritoneal_inflammation	2.75090028
11	MP0000749_muscle_degeneration	2.59480342
12	MP0000678_abnormal_parathyroid_gland	2.49179646
13	MP0004233_abnormal_muscle_weight	2.46797576
14	MP0000759_abnormal_skeletal_muscle	2.34823522
15	MP0004510_myositis	2.32319486
16	MP0003705_abnormal_hypodermis_morpholog	2.27944262
17	MP0000747_muscle_weakness	2.23876041
18	MP0004130_abnormal_muscle_cell	2.21747976
19	MP0002106_abnormal_muscle_physiology	2.15900261
20	MP0003436_decreased_susceptibility_to	2.13221323
21	MP0004087_abnormal_muscle_fiber	2.10699791
22	MP0005330_cardiomyopathy	2.06818591
23	MP0000733_abnormal_muscle_development	2.06675667
24	MP0002249_abnormal_larynx_morphology	1.99190323
25	MP0002138_abnormal_hepatobiliary_system	1.80249685
26	MP0002332_abnormal_exercise_endurance	1.79266447
27	MP0004036_abnormal_muscle_relaxation	1.74257906
28	MP0003191_abnormal_cellular_cholesterol	1.73927532
29	MP0003123_paternal_imprinting	1.70320150
30	MP0008260_abnormal_autophagy	1.68600990
31	MP0002139_abnormal_hepatobiliary_system	1.66561977
32	MP0005369_muscle_phenotype	1.65882888
33	MP0004185_abnormal_adipocyte_glucose	1.60710278
34	MP0005076_abnormal_cell_differentiation	1.54432231
35	MP0002653_abnormal_ependyma_morphology	1.46471035
36	MP0009333_abnormal_splenocyte_physiolog	1.42169265
37	MP0003453_abnormal_keratinocyte_physiol	1.39458798
38	MP0003172_abnormal_lysosome_physiology	1.39258445
39	MP0001348_abnormal_lacrimal_gland	1.37574242
40	MP0001545_abnormal_hematopoietic_system	1.30841872
41	MP0005397_hematopoietic_system_phenotyp	1.30841872
42	MP0005666_abnormal_adipose_tissue	1.26780665
43	MP0010630_abnormal_cardiac_muscle	1.25279627
44	MP0002269_muscular_atrophy	1.25130740
45	MP0005375_adipose_tissue_phenotype	1.19030445
46	MP0003879_abnormal_hair_cell	1.18864044
47	MP0006036_abnormal_mitochondrial_physio	1.18820883
48	MP0005083_abnormal_biliary_tract	1.18385679
49	MP0004858_abnormal_nervous_system	1.16965670
50	MP0005620_abnormal_muscle_contractility	1.16529453
51	MP0001346_abnormal_lacrimal_gland	1.16243873
52	MP0001849_ear_inflammation	1.11046153
53	MP0001661_extended_life_span	1.06048068
54	MP0005025_abnormal_response_to	0.97245086
55	MP0002132_abnormal_respiratory_system	0.96259250
56	MP0000049_abnormal_middle_ear	0.95549573
57	MP0000003_abnormal_adipose_tissue	0.94684179
58	MP0001873_stomach_inflammation	0.94663932
59	MP0002972_abnormal_cardiac_muscle	0.92326734
60	MP0002127_abnormal_cardiovascular_syste	0.91283230
61	MP0002419_abnormal_innate_immunity	0.89398658
62	MP0008004_abnormal_stomach_pH	0.88756973
63	MP0003806_abnormal_nucleotide_metabolis	0.85454314
64	MP0009379_abnormal_foot_pigmentation	0.85345473
65	MP0003279_aneurysm	0.85125513
66	MP0002234_abnormal_pharynx_morphology	0.85014704
67	MP0002822_catalepsy	0.84451709
68	MP0001663_abnormal_digestive_system	0.82835412
69	MP0003075_altered_response_to	0.82624479
70	MP0005464_abnormal_platelet_physiology	0.82106196
71	MP0002148_abnormal_hypersensitivity_rea	0.81814678
72	MP0005387_immune_system_phenotype	0.81289324
73	MP0001790_abnormal_immune_system	0.81289324
74	MP0002254_reproductive_system_inflammat	0.79643134
75	MP0006138_congestive_heart_failure	0.78556542
76	MP0002163_abnormal_gland_morphology	0.77287060
77	MP0000343_altered_response_to	0.76554084
78	MP0004947_skin_inflammation	0.75078431
79	MP0005670_abnormal_white_adipose	0.74227517
80	MP0005266_abnormal_metabolism	0.73258258
81	MP0003656_abnormal_erythrocyte_physiolo	0.73235496
82	MP0005166_decreased_susceptibility_to	0.72602517
83	MP0005409_darkened_coat_color	0.72390508
84	MP0002837_dystrophic_cardiac_calcinosis	0.70215105
85	MP0002723_abnormal_immune_serum	0.69823831
86	MP0002971_abnormal_brown_adipose	0.68678044
87	MP0008469_abnormal_protein_level	0.68243367
88	MP0005381_digestive/alimentary_phenotyp	0.68134218
89	MP0002089_abnormal_postnatal_growth/wei	0.67552163
90	MP0000685_abnormal_immune_system	0.64223665
91	MP0003878_abnormal_ear_physiology	0.64190029
92	MP0005377_hearing/vestibular/ear_phenot	0.64190029
93	MP0001727_abnormal_embryo_implantation	0.64160064
94	MP0000858_altered_metastatic_potential	0.63000423
95	MP0005000_abnormal_immune_tolerance	0.60262280
96	MP0001533_abnormal_skeleton_physiology	0.60229625
97	MP0002933_joint_inflammation	0.60157569
98	MP0002452_abnormal_antigen_presenting	0.59987939
99	MP0005385_cardiovascular_system_phenoty	0.58754472
100	MP0001544_abnormal_cardiovascular_syste	0.58754472

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Muscle fiber inclusion bodies (HP:0100299)	5.96958247
2	Exercise-induced myalgia (HP:0003738)	5.83989605
3	Nemaline bodies (HP:0003798)	5.76295072
4	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	5.68172880
5	Myopathic facies (HP:0002058)	5.55310213
6	Type 1 muscle fiber predominance (HP:0003803)	5.11272474
7	Muscle hypertrophy of the lower extremities (HP:0008968)	3.91887754
8	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.72193460
9	Bulbar palsy (HP:0001283)	3.65862136
10	Ulnar deviation of the wrist (HP:0003049)	3.57491760
11	Calf muscle hypertrophy (HP:0008981)	3.50193158
12	Asymmetric septal hypertrophy (HP:0001670)	3.44093787
13	Round ear (HP:0100830)	3.42606067
14	Abnormality of skeletal muscle fiber size (HP:0012084)	3.41102930
15	Distal arthrogryposis (HP:0005684)	3.35956838
16	Distal lower limb muscle weakness (HP:0009053)	3.31297996
17	Exercise-induced muscle cramps (HP:0003710)	3.19742320
18	Subaortic stenosis (HP:0001682)	3.15954747
19	Abnormality of the left ventricular outflow tract (HP:0011103)	3.15954747
20	Increased variability in muscle fiber diameter (HP:0003557)	3.14586805
21	Congenital malformation of the right heart (HP:0011723)	3.14322815
22	Double outlet right ventricle (HP:0001719)	3.14322815
23	Muscle fiber splitting (HP:0003555)	2.99046992
24	Rhabdomyolysis (HP:0003201)	2.91425471
25	Increased connective tissue (HP:0009025)	2.88706840
26	EMG: myopathic abnormalities (HP:0003458)	2.87418595
27	Abnormality of the calf musculature (HP:0001430)	2.83775319
28	Calcaneovalgus deformity (HP:0001848)	2.81832458
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.79827062
30	Recurrent bacterial skin infections (HP:0005406)	2.77763245
31	Progressive muscle weakness (HP:0003323)	2.70683024
32	Hyperthyroidism (HP:0000836)	2.67840008
33	Muscle stiffness (HP:0003552)	2.62714639
34	Difficulty running (HP:0009046)	2.62522138
35	Truncus arteriosus (HP:0001660)	2.59347630
36	Recurrent abscess formation (HP:0002722)	2.55992304
37	Myoglobinuria (HP:0002913)	2.55808303
38	Hyporeflexia of lower limbs (HP:0002600)	2.52438770
39	Increased muscle lipid content (HP:0009058)	2.49356048
40	Ragged-red muscle fibers (HP:0003200)	2.47495854
41	Abnormality of the aortic arch (HP:0012303)	2.43156549
42	Rectal prolapse (HP:0002035)	2.42986503
43	Stridor (HP:0010307)	2.41608279
44	EMG: neuropathic changes (HP:0003445)	2.37483556
45	Increased cerebral lipofuscin (HP:0011813)	2.35868377
46	Deformed tarsal bones (HP:0008119)	2.35653130
47	Thin bony cortex (HP:0002753)	2.34930741
48	Increased intramyocellular lipid droplets (HP:0012240)	2.32187101
49	Cholelithiasis (HP:0001081)	2.30056008
50	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.26666807
51	Hypertensive crisis (HP:0100735)	2.17798092
52	Malignant hyperthermia (HP:0002047)	2.16350193
53	Obstructive lung disease (HP:0006536)	2.15513302
54	Chronic obstructive pulmonary disease (HP:0006510)	2.15513302
55	Abnormality of the tricuspid valve (HP:0001702)	2.13500575
56	Mildly elevated creatine phosphokinase (HP:0008180)	2.09829022
57	Obstructive sleep apnea (HP:0002870)	2.08323923
58	Easy fatigability (HP:0003388)	2.07651491
59	Spinal rigidity (HP:0003306)	2.05875095
60	Hypoplastic heart (HP:0001961)	2.04430736
61	Neck muscle weakness (HP:0000467)	2.04360635
62	Ventricular tachycardia (HP:0004756)	2.03710432
63	Turricephaly (HP:0000262)	2.02538769
64	Bowel incontinence (HP:0002607)	2.00841897
65	Myotonia (HP:0002486)	1.99042443
66	Abnormal large intestine physiology (HP:0012700)	1.98793311
67	Abnormality of the calcaneus (HP:0008364)	1.98013986
68	Transposition of the great arteries (HP:0001669)	1.97154342
69	Abnormal connection of the cardiac segments (HP:0011545)	1.97154342
70	Abnormal ventriculo-arterial connection (HP:0011563)	1.97154342
71	Difficulty climbing stairs (HP:0003551)	1.94843617
72	Preauricular pit (HP:0004467)	1.91337213
73	Periauricular skin pits (HP:0100277)	1.91337213
74	Waddling gait (HP:0002515)	1.90710728
75	Distal lower limb amyotrophy (HP:0008944)	1.90601043
76	Generalized muscle weakness (HP:0003324)	1.90063015
77	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.89713022
78	Abnormal gallbladder morphology (HP:0012437)	1.89396893
79	Male infertility (HP:0003251)	1.89027889
80	Diaphragmatic weakness (HP:0009113)	1.86326623
81	Achilles tendon contracture (HP:0001771)	1.85834984
82	Mesangial abnormality (HP:0001966)	1.85679712
83	Rimmed vacuoles (HP:0003805)	1.82865882
84	Hemorrhage of the eye (HP:0011885)	1.82604632
85	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.82349026
86	Short palpebral fissure (HP:0012745)	1.79623412
87	Hypoplastic left heart (HP:0004383)	1.78745160
88	Paralysis (HP:0003470)	1.78318578
89	Dilated cardiomyopathy (HP:0001644)	1.76901065
90	Abnormal atrioventricular conduction (HP:0005150)	1.75783026
91	Increased serum ferritin (HP:0003281)	1.74720533
92	Heart block (HP:0012722)	1.73747953
93	Bundle branch block (HP:0011710)	1.72835717
94	Abnormality of the gallbladder (HP:0005264)	1.72612395
95	Fetal akinesia sequence (HP:0001989)	1.70565801
96	Ulnar bowing (HP:0003031)	1.70025812
97	Reticulocytosis (HP:0001923)	1.69622049
98	Neonatal hypoglycemia (HP:0001998)	1.69412781
99	Renal Fanconi syndrome (HP:0001994)	1.67622477
100	Gowers sign (HP:0003391)	1.67499672

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SMG1	4.16489809
2	TRIB3	3.93441216
3	TTN	3.36938301
4	OBSCN	3.19887227
5	SIK1	2.76887889
6	NME2	2.75920604
7	PRPF4B	2.74810475
8	MAP2K3	2.53680811
9	IRAK3	2.50652109
10	ERN1	2.35798889
11	ICK	2.22528037
12	MAP3K11	1.97155767
13	PHKG1	1.90362984
14	PHKG2	1.90362984
15	PRKD3	1.86922347
16	STK16	1.80527437
17	RIPK1	1.77575123
18	VRK2	1.58185067
19	TAOK2	1.53923129
20	DYRK1B	1.53457854
21	MAP3K10	1.42954727
22	IRAK4	1.38785054
23	TBK1	1.37274250
24	MAPK12	1.32438158
25	RPS6KC1	1.28781424
26	RPS6KL1	1.28781424
27	TAF1	1.27322178
28	EEF2K	1.24783749
29	IRAK2	1.22819833
30	BLK	1.18875957
31	MAPK15	1.18399015
32	MAP3K3	1.15618199
33	MAP3K1	1.14262663
34	MUSK	1.10604790
35	MAP4K1	1.10238310
36	RPS6KA6	1.07188067
37	RPS6KA2	1.06845336
38	TAOK1	1.04813712
39	TYK2	1.01510997
40	MARK2	0.99325021
41	PRKD2	0.93117710
42	CDC42BPA	0.90592218
43	MAPK11	0.88618086
44	DYRK3	0.87669085
45	MAP3K13	0.86271207
46	EPHB2	0.85236364
47	HIPK2	0.82060119
48	BRAF	0.80675685
49	CAMK1D	0.80087190
50	MOS	0.79164297
51	ABL2	0.78050447
52	ARAF	0.72798023
53	PDPK1	0.72348247
54	MAPK4	0.71822425
55	TNK2	0.71273566
56	GRK6	0.70957943
57	MAP3K7	0.69702252
58	IKBKB	0.69479951
59	PKN2	0.69292624
60	DMPK	0.67229672
61	DAPK3	0.65337362
62	CSK	0.64824727
63	MTOR	0.61524788
64	RIPK4	0.61415503
65	CDK19	0.60599944
66	MAP2K2	0.60479959
67	STK11	0.59770658
68	BMX	0.58389863
69	ZAP70	0.58368665
70	EPHB1	0.57890203
71	BCKDK	0.55810231
72	CDK4	0.53691709
73	MELK	0.53650164
74	MAPK7	0.53460678
75	NME1	0.53428572
76	RPS6KA1	0.52367257
77	KSR2	0.52141472
78	LRRK2	0.51377261
79	PTK6	0.50187646
80	MAP2K6	0.50103214
81	PIK3CG	0.50043848
82	MAP2K4	0.43516732
83	CHUK	0.42392047
84	MATK	0.42117112
85	TYRO3	0.41130127
86	PRKAA2	0.40742169
87	MAP3K6	0.39715648
88	PRKAA1	0.39494160
89	PIM2	0.39020332
90	FGFR4	0.38569160
91	MAP3K8	0.36982012
92	BTK	0.35999509
93	CAMK4	0.33402189
94	IKBKE	0.33198223
95	JAK3	0.32681664
96	TGFBR2	0.31952870
97	EPHA2	0.31661611
98	PDK1	0.31235943
99	DDR2	0.30331057
100	PRKG2	0.29852620

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	4.72791651
2	Other glycan degradation_Homo sapiens_hsa00511	3.34680242
3	Notch signaling pathway_Homo sapiens_hsa04330	2.75339702
4	Ribosome_Homo sapiens_hsa03010	2.67389576
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.40095873
6	Pentose phosphate pathway_Homo sapiens_hsa00030	2.19197205
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.09742361
8	Galactose metabolism_Homo sapiens_hsa00052	1.87923303
9	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.85800282
10	Bladder cancer_Homo sapiens_hsa05219	1.77835241
11	Acute myeloid leukemia_Homo sapiens_hsa05221	1.67200770
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.65116539
13	VEGF signaling pathway_Homo sapiens_hsa04370	1.64096196
14	Insulin signaling pathway_Homo sapiens_hsa04910	1.58727746
15	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.56829771
16	Osteoclast differentiation_Homo sapiens_hsa04380	1.53765912
17	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.53484306
18	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.53475155
19	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.51987064
20	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.50438929
21	Sulfur metabolism_Homo sapiens_hsa00920	1.49210260
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.44316704
23	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.42377331
24	Insulin resistance_Homo sapiens_hsa04931	1.40546051
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.34824176
26	Carbon metabolism_Homo sapiens_hsa01200	1.31773050
27	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.22896041
28	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.22546523
29	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.16677956
30	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.16193951
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.16179753
32	Non-small cell lung cancer_Homo sapiens_hsa05223	1.15576014
33	Lysosome_Homo sapiens_hsa04142	1.15313671
34	mTOR signaling pathway_Homo sapiens_hsa04150	1.12378981
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11501356
36	Basal cell carcinoma_Homo sapiens_hsa05217	1.10574383
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08574058
38	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.08099035
39	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.07624779
40	Phenylalanine metabolism_Homo sapiens_hsa00360	1.06588935
41	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.05796296
42	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.05733855
43	AMPK signaling pathway_Homo sapiens_hsa04152	1.01082350
44	Leishmaniasis_Homo sapiens_hsa05140	0.94655436
45	Arginine biosynthesis_Homo sapiens_hsa00220	0.93020195
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92678146
47	Glucagon signaling pathway_Homo sapiens_hsa04922	0.92409172
48	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.91521574
49	Prion diseases_Homo sapiens_hsa05020	0.90056243
50	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.86298324
51	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.86229864
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.85050019
53	Hepatitis C_Homo sapiens_hsa05160	0.80001899
54	Tuberculosis_Homo sapiens_hsa05152	0.77761167
55	TNF signaling pathway_Homo sapiens_hsa04668	0.75774317
56	Pancreatic cancer_Homo sapiens_hsa05212	0.75331106
57	Malaria_Homo sapiens_hsa05144	0.74211686
58	Endometrial cancer_Homo sapiens_hsa05213	0.72510589
59	Hepatitis B_Homo sapiens_hsa05161	0.71137260
60	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.71101913
61	GnRH signaling pathway_Homo sapiens_hsa04912	0.70841321
62	Base excision repair_Homo sapiens_hsa03410	0.70607467
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.70129990
64	MAPK signaling pathway_Homo sapiens_hsa04010	0.67893303
65	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.66478118
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65897099
67	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.65608151
68	Apoptosis_Homo sapiens_hsa04210	0.63582952
69	HTLV-I infection_Homo sapiens_hsa05166	0.63333201
70	Alzheimers disease_Homo sapiens_hsa05010	0.60664958
71	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.59852571
72	FoxO signaling pathway_Homo sapiens_hsa04068	0.59416562
73	Sphingolipid metabolism_Homo sapiens_hsa00600	0.57747242
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.56117651
75	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.55696419
76	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55136137
77	Pertussis_Homo sapiens_hsa05133	0.54587699
78	Fatty acid degradation_Homo sapiens_hsa00071	0.54156757
79	Influenza A_Homo sapiens_hsa05164	0.50724632
80	Prolactin signaling pathway_Homo sapiens_hsa04917	0.50641296
81	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48427777
82	Thyroid cancer_Homo sapiens_hsa05216	0.48407919
83	PPAR signaling pathway_Homo sapiens_hsa03320	0.48388695
84	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.47822349
85	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.47790752
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47102231
87	Renal cell carcinoma_Homo sapiens_hsa05211	0.46755835
88	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.46707966
89	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.42265782
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41673466
91	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.41191482
92	Parkinsons disease_Homo sapiens_hsa05012	0.41038175
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.40214035
94	Toxoplasmosis_Homo sapiens_hsa05145	0.39888764
95	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.38360215
96	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38352549
97	Melanogenesis_Homo sapiens_hsa04916	0.37150649
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36714355
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.36397374
100	Herpes simplex infection_Homo sapiens_hsa05168	0.35912033

ZNF784

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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