ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.37037897
2	L-fucose catabolic process (GO:0042355)	4.75980057
3	fucose catabolic process (GO:0019317)	4.75980057
4	L-fucose metabolic process (GO:0042354)	4.75980057
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.00092126
6	tryptophan catabolic process (GO:0006569)	3.64132766
7	indole-containing compound catabolic process (GO:0042436)	3.64132766
8	indolalkylamine catabolic process (GO:0046218)	3.64132766
9	response to pheromone (GO:0019236)	3.60304707
10	detection of light stimulus involved in visual perception (GO:0050908)	3.53254721
11	detection of light stimulus involved in sensory perception (GO:0050962)	3.53254721
12	indolalkylamine metabolic process (GO:0006586)	3.52923679
13	DNA deamination (GO:0045006)	3.31845494
14	epithelial cilium movement (GO:0003351)	3.29811955
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.26930555
16	gamma-aminobutyric acid transport (GO:0015812)	3.24126375
17	pyrimidine nucleobase catabolic process (GO:0006208)	3.23288473
18	cellular ketone body metabolic process (GO:0046950)	3.19974576
19	negative regulation of telomere maintenance (GO:0032205)	3.18584109
20	kynurenine metabolic process (GO:0070189)	3.15397678
21	synaptic transmission, cholinergic (GO:0007271)	3.11925091
22	postsynaptic membrane organization (GO:0001941)	3.11836363
23	axoneme assembly (GO:0035082)	3.11806836
24	nonmotile primary cilium assembly (GO:0035058)	3.10487394
25	tryptophan metabolic process (GO:0006568)	3.06362804
26	neural tube formation (GO:0001841)	3.05408124
27	neuronal action potential (GO:0019228)	3.04132405
28	cornea development in camera-type eye (GO:0061303)	3.02402639
29	protein-cofactor linkage (GO:0018065)	2.98472467
30	nucleobase catabolic process (GO:0046113)	2.95405029
31	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.95068765
32	regulation of translation, ncRNA-mediated (GO:0045974)	2.95068765
33	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.95068765
34	behavioral response to ethanol (GO:0048149)	2.93618341
35	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.93086439
36	regulation of action potential (GO:0098900)	2.88946205
37	spinal cord motor neuron differentiation (GO:0021522)	2.88814842
38	ketone body metabolic process (GO:1902224)	2.88459477
39	cilium movement (GO:0003341)	2.84696959
40	retinal cone cell development (GO:0046549)	2.81487720
41	sulfation (GO:0051923)	2.80769036
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78478104
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78478104
44	NADH dehydrogenase complex assembly (GO:0010257)	2.78478104
45	nephron epithelium morphogenesis (GO:0072088)	2.78463324
46	nephron tubule morphogenesis (GO:0072078)	2.78463324
47	cilium morphogenesis (GO:0060271)	2.77996234
48	respiratory chain complex IV assembly (GO:0008535)	2.76735161
49	kidney morphogenesis (GO:0060993)	2.75093453
50	indole-containing compound metabolic process (GO:0042430)	2.74414453
51	protein complex biogenesis (GO:0070271)	2.74134405
52	protein polyglutamylation (GO:0018095)	2.73775398
53	cilium or flagellum-dependent cell motility (GO:0001539)	2.72213734
54	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.72049167
55	photoreceptor cell maintenance (GO:0045494)	2.71300107
56	urinary tract smooth muscle contraction (GO:0014848)	2.69526563
57	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.68609850
58	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66993222
59	cAMP catabolic process (GO:0006198)	2.66211629
60	fucosylation (GO:0036065)	2.65674840
61	amine catabolic process (GO:0009310)	2.62936356
62	cellular biogenic amine catabolic process (GO:0042402)	2.62936356
63	cilium organization (GO:0044782)	2.62621290
64	water-soluble vitamin biosynthetic process (GO:0042364)	2.62282389
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.58766940
66	platelet dense granule organization (GO:0060155)	2.58233956
67	primary amino compound metabolic process (GO:1901160)	2.57386888
68	cilium assembly (GO:0042384)	2.56385064
69	presynaptic membrane assembly (GO:0097105)	2.56310591
70	neuromuscular synaptic transmission (GO:0007274)	2.56074465
71	photoreceptor cell development (GO:0042461)	2.54758335
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.53878000
73	somite development (GO:0061053)	2.53251194
74	membrane depolarization during action potential (GO:0086010)	2.52192607
75	reflex (GO:0060004)	2.50963928
76	adaptation of signaling pathway (GO:0023058)	2.50948830
77	regulation of hippo signaling (GO:0035330)	2.50828528
78	protein import into peroxisome matrix (GO:0016558)	2.49658530
79	reciprocal meiotic recombination (GO:0007131)	2.49632689
80	reciprocal DNA recombination (GO:0035825)	2.49632689
81	regulation of telomere maintenance (GO:0032204)	2.49241224
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.48450835
83	transmission of nerve impulse (GO:0019226)	2.47755821
84	startle response (GO:0001964)	2.47382668
85	piRNA metabolic process (GO:0034587)	2.46687681
86	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.45777837
87	neuron cell-cell adhesion (GO:0007158)	2.45774329
88	regulation of cilium movement (GO:0003352)	2.45468095
89	cell differentiation in spinal cord (GO:0021515)	2.45045471
90	neuronal action potential propagation (GO:0019227)	2.44231013
91	rhodopsin mediated signaling pathway (GO:0016056)	2.43256140
92	inner ear receptor stereocilium organization (GO:0060122)	2.42994729
93	cyclic nucleotide catabolic process (GO:0009214)	2.41902010
94	protein localization to cilium (GO:0061512)	2.40423318
95	hindbrain development (GO:0030902)	2.39785070
96	serotonin metabolic process (GO:0042428)	2.39350109
97	regulation of posttranscriptional gene silencing (GO:0060147)	2.37968626
98	regulation of gene silencing by miRNA (GO:0060964)	2.37968626
99	regulation of gene silencing by RNA (GO:0060966)	2.37968626
100	proline transport (GO:0015824)	2.37730130

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.17810095
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.10625829
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.06977042
4	VDR_22108803_ChIP-Seq_LS180_Human	3.04713787
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.84306675
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49231247
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42868046
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30876989
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.24593253
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23436205
11	EWS_26573619_Chip-Seq_HEK293_Human	2.05227296
12	FUS_26573619_Chip-Seq_HEK293_Human	1.97733311
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.93408145
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87539973
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.86093958
16	REST_21632747_ChIP-Seq_MESCs_Mouse	1.86035602
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.85335889
18	P300_19829295_ChIP-Seq_ESCs_Human	1.85238528
19	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78697456
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.69677417
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68119412
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65770516
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63705568
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.62050215
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62050215
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.61640098
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61053637
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.59406736
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56465992
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54336354
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53946582
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52600072
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.51916791
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50737020
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49598423
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47929856
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.46885843
38	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46405110
39	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.45700423
40	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.44082546
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43759801
42	STAT3_23295773_ChIP-Seq_U87_Human	1.42933257
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40539117
44	AR_25329375_ChIP-Seq_VCAP_Human	1.40335164
45	DROSHA_22980978_ChIP-Seq_HELA_Human	1.39478289
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39317454
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38616108
48	AR_21572438_ChIP-Seq_LNCaP_Human	1.38387336
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36404349
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36233890
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35680425
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34037957
53	TCF4_23295773_ChIP-Seq_U87_Human	1.32818229
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32317065
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.32317065
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29657376
57	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.29110783
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27794734
59	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.25888444
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.25233928
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24805442
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22550361
63	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.21980979
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21432750
65	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20960716
66	* ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20718274
67	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.20209636
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20171681
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19502283
70	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.18714717
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.17949641
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17897695
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17897695
74	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17767524
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16765089
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.15369438
77	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.14524101
78	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.14213460
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13759202
80	* NCOR_22424771_ChIP-Seq_293T_Human	1.12897222
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12868023
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09518254
83	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.08574533
84	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.08574533
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06731838
86	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06720847
87	* ERA_21632823_ChIP-Seq_H3396_Human	1.05744878
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05466159
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04511452
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04309746
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02633225
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99642400
93	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.98655998
94	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98258377
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98102945
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98082220
97	AR_20517297_ChIP-Seq_VCAP_Human	0.97753196
98	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97226248
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.96639395
100	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96145354

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.01808775
2	MP0003136_yellow_coat_color	2.80829787
3	MP0001968_abnormal_touch/_nociception	2.55465242
4	MP0002638_abnormal_pupillary_reflex	2.41250591
5	MP0008877_abnormal_DNA_methylation	2.36440609
6	MP0005551_abnormal_eye_electrophysiolog	2.34837347
7	MP0003880_abnormal_central_pattern	2.26738007
8	MP0002653_abnormal_ependyma_morphology	2.25261061
9	MP0006292_abnormal_olfactory_placode	2.23339729
10	MP0002102_abnormal_ear_morphology	2.20050893
11	MP0003787_abnormal_imprinting	2.17156084
12	MP0009046_muscle_twitch	2.08468652
13	MP0009745_abnormal_behavioral_response	2.07417598
14	MP0006072_abnormal_retinal_apoptosis	2.05973445
15	MP0004885_abnormal_endolymph	1.97876390
16	MP0005645_abnormal_hypothalamus_physiol	1.95424032
17	MP0005174_abnormal_tail_pigmentation	1.92446417
18	MP0002735_abnormal_chemical_nociception	1.91217442
19	MP0003195_calcinosis	1.90779192
20	MP0002736_abnormal_nociception_after	1.87995285
21	MP0004133_heterotaxia	1.86190387
22	MP0002272_abnormal_nervous_system	1.84191781
23	MP0001485_abnormal_pinna_reflex	1.83282521
24	MP0006276_abnormal_autonomic_nervous	1.82414622
25	MP0001986_abnormal_taste_sensitivity	1.79752746
26	MP0000631_abnormal_neuroendocrine_gland	1.73194793
27	MP0002837_dystrophic_cardiac_calcinosis	1.68108325
28	MP0004142_abnormal_muscle_tone	1.67676791
29	MP0002938_white_spotting	1.64483320
30	MP0002572_abnormal_emotion/affect_behav	1.64421555
31	MP0005646_abnormal_pituitary_gland	1.61111279
32	MP0008872_abnormal_physiological_respon	1.60684412
33	MP0005253_abnormal_eye_physiology	1.59356202
34	MP0001486_abnormal_startle_reflex	1.56155308
35	MP0000372_irregular_coat_pigmentation	1.53196490
36	MP0002064_seizures	1.52059059
37	MP0004147_increased_porphyrin_level	1.51256560
38	MP0002928_abnormal_bile_duct	1.49660476
39	MP0003635_abnormal_synaptic_transmissio	1.47558924
40	MP0000778_abnormal_nervous_system	1.46795973
41	MP0001970_abnormal_pain_threshold	1.44036243
42	MP0001501_abnormal_sleep_pattern	1.43789317
43	MP0002557_abnormal_social/conspecific_i	1.40114979
44	MP0004742_abnormal_vestibular_system	1.39741131
45	MP0002733_abnormal_thermal_nociception	1.38139831
46	MP0004043_abnormal_pH_regulation	1.37549039
47	MP0002876_abnormal_thyroid_physiology	1.36178196
48	MP0008875_abnormal_xenobiotic_pharmacok	1.35589950
49	MP0001529_abnormal_vocalization	1.35525538
50	MP0005423_abnormal_somatic_nervous	1.32351899
51	MP0002063_abnormal_learning/memory/cond	1.32172662
52	MP0001984_abnormal_olfaction	1.32072825
53	MP0002067_abnormal_sensory_capabilities	1.30493183
54	MP0000427_abnormal_hair_cycle	1.26387148
55	MP0010386_abnormal_urinary_bladder	1.24496764
56	MP0004145_abnormal_muscle_electrophysio	1.19301737
57	MP0004924_abnormal_behavior	1.18274853
58	MP0005386_behavior/neurological_phenoty	1.18274853
59	MP0003646_muscle_fatigue	1.18128011
60	MP0002822_catalepsy	1.17140625
61	MP0002751_abnormal_autonomic_nervous	1.16679824
62	MP0008995_early_reproductive_senescence	1.12314679
63	MP0005084_abnormal_gallbladder_morpholo	1.12213908
64	MP0003121_genomic_imprinting	1.12179278
65	MP0002095_abnormal_skin_pigmentation	1.11991424
66	MP0000026_abnormal_inner_ear	1.10907907
67	MP0003011_delayed_dark_adaptation	1.09977062
68	MP0002752_abnormal_somatic_nervous	1.09359721
69	MP0002184_abnormal_innervation	1.09195208
70	MP0003283_abnormal_digestive_organ	1.08993576
71	MP0001905_abnormal_dopamine_level	1.07251264
72	MP0005195_abnormal_posterior_eye	1.04500801
73	MP0000383_abnormal_hair_follicle	1.03297412
74	MP0002277_abnormal_respiratory_mucosa	1.01389889
75	MP0000015_abnormal_ear_pigmentation	1.01106284
76	MP0002160_abnormal_reproductive_system	1.00358877
77	MP0002734_abnormal_mechanical_nocicepti	0.98399022
78	MP0005075_abnormal_melanosome_morpholog	0.97138066
79	MP0001963_abnormal_hearing_physiology	0.95654746
80	MP0001502_abnormal_circadian_rhythm	0.95494428
81	MP0003878_abnormal_ear_physiology	0.93656047
82	MP0005377_hearing/vestibular/ear_phenot	0.93656047
83	MP0002138_abnormal_hepatobiliary_system	0.90510869
84	MP0008789_abnormal_olfactory_epithelium	0.89613445
85	MP0003122_maternal_imprinting	0.89591213
86	MP0000955_abnormal_spinal_cord	0.89554993
87	MP0000566_synostosis	0.87717175
88	MP0002882_abnormal_neuron_morphology	0.87051340
89	MP0000538_abnormal_urinary_bladder	0.85988373
90	MP0005389_reproductive_system_phenotype	0.84925479
91	MP0005171_absent_coat_pigmentation	0.83879981
92	MP0002229_neurodegeneration	0.81690387
93	MP0000049_abnormal_middle_ear	0.81145275
94	MP0003938_abnormal_ear_development	0.77477722
95	MP0003698_abnormal_male_reproductive	0.76901451
96	MP0004859_abnormal_synaptic_plasticity	0.76078418
97	MP0003119_abnormal_digestive_system	0.74412224
98	MP0005499_abnormal_olfactory_system	0.74020521
99	MP0005394_taste/olfaction_phenotype	0.74020521
100	MP0001440_abnormal_grooming_behavior	0.73204991

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.67699605
2	Congenital stationary night blindness (HP:0007642)	4.62253817
3	Abnormality of midbrain morphology (HP:0002418)	4.33063370
4	Molar tooth sign on MRI (HP:0002419)	4.33063370
5	Pancreatic fibrosis (HP:0100732)	4.10310378
6	True hermaphroditism (HP:0010459)	4.03549418
7	Nephronophthisis (HP:0000090)	3.90449907
8	Abnormality of the renal medulla (HP:0100957)	3.40571996
9	Hyperventilation (HP:0002883)	3.39400027
10	Abnormality of the renal cortex (HP:0011035)	3.10476962
11	Medial flaring of the eyebrow (HP:0010747)	2.98451797
12	Cystic liver disease (HP:0006706)	2.95924679
13	Type II lissencephaly (HP:0007260)	2.86584688
14	Chronic hepatic failure (HP:0100626)	2.82073001
15	Attenuation of retinal blood vessels (HP:0007843)	2.68876295
16	Febrile seizures (HP:0002373)	2.67805488
17	Tubular atrophy (HP:0000092)	2.64411023
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.64151738
19	Polydipsia (HP:0001959)	2.63334951
20	Abnormal drinking behavior (HP:0030082)	2.63334951
21	Bile duct proliferation (HP:0001408)	2.61425255
22	Abnormal biliary tract physiology (HP:0012439)	2.61425255
23	Progressive cerebellar ataxia (HP:0002073)	2.60125600
24	Inability to walk (HP:0002540)	2.52410830
25	Concave nail (HP:0001598)	2.48610432
26	Genetic anticipation (HP:0003743)	2.47803232
27	Abolished electroretinogram (ERG) (HP:0000550)	2.44004010
28	Pendular nystagmus (HP:0012043)	2.42357125
29	Gait imbalance (HP:0002141)	2.42201416
30	Hemiparesis (HP:0001269)	2.41957915
31	Sclerocornea (HP:0000647)	2.39185624
32	Gaze-evoked nystagmus (HP:0000640)	2.33861856
33	Large for gestational age (HP:0001520)	2.27840614
34	Protruding tongue (HP:0010808)	2.27789695
35	Broad-based gait (HP:0002136)	2.27770093
36	Absent/shortened dynein arms (HP:0200106)	2.25366236
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.25366236
38	Congenital hepatic fibrosis (HP:0002612)	2.23462461
39	Decreased circulating renin level (HP:0003351)	2.22996246
40	Congenital primary aphakia (HP:0007707)	2.22269528
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.21661567
42	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21661567
43	Limb dystonia (HP:0002451)	2.20937928
44	Anencephaly (HP:0002323)	2.20753975
45	Furrowed tongue (HP:0000221)	2.17572353
46	Focal motor seizures (HP:0011153)	2.16345690
47	Cerebellar dysplasia (HP:0007033)	2.16188574
48	Patellar aplasia (HP:0006443)	2.12750168
49	Rib fusion (HP:0000902)	2.12139301
50	Progressive inability to walk (HP:0002505)	2.10727778
51	Renal cortical cysts (HP:0000803)	2.10320132
52	Lissencephaly (HP:0001339)	2.10218604
53	Decreased central vision (HP:0007663)	2.09639485
54	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09056203
55	Optic nerve hypoplasia (HP:0000609)	2.08462612
56	Nephrogenic diabetes insipidus (HP:0009806)	2.08065396
57	Polyuria (HP:0000103)	2.07676496
58	Focal seizures (HP:0007359)	2.06416492
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06005912
60	Congenital, generalized hypertrichosis (HP:0004540)	2.05292207
61	Abnormality of the labia minora (HP:0012880)	2.05083697
62	Male pseudohermaphroditism (HP:0000037)	2.02328728
63	Abnormality of alanine metabolism (HP:0010916)	2.00869908
64	Hyperalaninemia (HP:0003348)	2.00869908
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.00869908
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00806610
67	Abnormality of the pons (HP:0007361)	2.00306472
68	Aplasia/Hypoplasia of the patella (HP:0006498)	2.00210363
69	Hypoplasia of the pons (HP:0012110)	1.98805477
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.97039094
71	Increased corneal curvature (HP:0100692)	1.94163894
72	Keratoconus (HP:0000563)	1.94163894
73	Bony spicule pigmentary retinopathy (HP:0007737)	1.93193007
74	Genital tract atresia (HP:0001827)	1.93130989
75	Absent speech (HP:0001344)	1.90933101
76	Vaginal atresia (HP:0000148)	1.89643022
77	Pachygyria (HP:0001302)	1.88520462
78	Clumsiness (HP:0002312)	1.87396111
79	Abnormal ciliary motility (HP:0012262)	1.85993553
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85981980
81	Hypothermia (HP:0002045)	1.84320494
82	Severe muscular hypotonia (HP:0006829)	1.83315459
83	Postaxial foot polydactyly (HP:0001830)	1.82544884
84	Abnormality of the renal collecting system (HP:0004742)	1.81474577
85	Asplenia (HP:0001746)	1.80433570
86	Chorioretinal atrophy (HP:0000533)	1.79935854
87	Abnormal number of erythroid precursors (HP:0012131)	1.78230124
88	Stomach cancer (HP:0012126)	1.76368205
89	Tachypnea (HP:0002789)	1.76023285
90	Mitochondrial inheritance (HP:0001427)	1.75878054
91	Congenital sensorineural hearing impairment (HP:0008527)	1.74275293
92	Poor coordination (HP:0002370)	1.73753456
93	Postaxial hand polydactyly (HP:0001162)	1.73515719
94	Duplicated collecting system (HP:0000081)	1.72871347
95	Partial agenesis of the corpus callosum (HP:0001338)	1.70846829
96	Epileptic encephalopathy (HP:0200134)	1.68432786
97	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.67894154
98	Narrow forehead (HP:0000341)	1.67577970
99	Bilateral microphthalmos (HP:0007633)	1.67554081
100	Septo-optic dysplasia (HP:0100842)	1.67249423

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.17901704
2	ADRBK2	3.53220584
3	BMPR1B	3.29640395
4	GRK1	2.75931673
5	WNK3	2.55204714
6	PINK1	2.54942832
7	ZAK	2.45686710
8	TLK1	2.38132952
9	MAP4K2	2.30568055
10	WNK4	2.30264776
11	CASK	2.23029813
12	ACVR1B	2.17689965
13	NUAK1	2.14187875
14	INSRR	2.13829849
15	MAPK13	2.07604125
16	MAP3K4	1.93688267
17	MARK1	1.92661593
18	TAOK3	1.89981922
19	MAPK15	1.73940318
20	DAPK2	1.62966312
21	NTRK3	1.59348755
22	PNCK	1.53837083
23	DYRK2	1.45155904
24	OXSR1	1.40709161
25	SIK2	1.34253361
26	PAK3	1.32051231
27	TNIK	1.30606130
28	TGFBR1	1.29794331
29	ADRBK1	1.28766139
30	MAP2K7	1.28563470
31	FGFR2	1.25125234
32	NTRK2	1.20398069
33	STK39	1.18067659
34	MKNK2	1.14557804
35	PRKCG	1.08826026
36	CAMKK2	1.02625733
37	TXK	1.01343355
38	VRK1	0.95872708
39	TRIM28	0.95124929
40	PRKCE	0.93213875
41	MUSK	0.91720246
42	TIE1	0.86514471
43	BCKDK	0.85426884
44	MAPKAPK3	0.85009690
45	KIT	0.79946363
46	EPHA4	0.74057793
47	PHKG1	0.74015079
48	PHKG2	0.74015079
49	PKN1	0.73864319
50	STK11	0.73181634
51	CAMK1	0.66228312
52	DYRK1A	0.66070050
53	PRKCQ	0.65558218
54	NEK2	0.65149513
55	CSNK1G2	0.63792846
56	PIK3CA	0.63557080
57	PTK2B	0.63340702
58	NLK	0.62496500
59	TNK2	0.62007248
60	CAMKK1	0.59306918
61	CDK3	0.58744146
62	MAPKAPK5	0.58375178
63	DYRK3	0.56885544
64	MAP2K6	0.56738636
65	IKBKB	0.54992795
66	RPS6KA5	0.54574509
67	CSNK1G1	0.54016554
68	CAMK2A	0.51816888
69	PRKACA	0.50491316
70	PASK	0.50066868
71	CHUK	0.49306688
72	CSNK1A1	0.48870071
73	STK38L	0.48163591
74	CSNK1G3	0.47074638
75	SGK2	0.45648671
76	TEC	0.45336257
77	CSNK1A1L	0.44146523
78	SGK223	0.43078537
79	SGK494	0.43078537
80	MKNK1	0.42850174
81	MAP2K4	0.42676577
82	SYK	0.42484884
83	PRKCZ	0.42108290
84	WEE1	0.41867082
85	ERBB2	0.40814795
86	MAP3K7	0.39328577
87	RPS6KA6	0.37760957
88	PRKCI	0.37632917
89	PRKCH	0.37013495
90	PLK2	0.36290373
91	PRKAA1	0.36019266
92	FLT3	0.34274368
93	PRKG1	0.33894306
94	OBSCN	0.33461919
95	ITK	0.32716265
96	CSNK1D	0.32566006
97	CDK19	0.31774820
98	PRKCA	0.31651323
99	CAMK1D	0.31404392
100	ATR	0.30496385

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.11906240
2	Nicotine addiction_Homo sapiens_hsa05033	2.77882402
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.59503672
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.57887601
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.44761051
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.37193677
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.35203366
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.25659068
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.21699857
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.20079535
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.09590290
12	Butanoate metabolism_Homo sapiens_hsa00650	2.04069166
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.99947519
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99237418
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91516024
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.90801760
17	Taste transduction_Homo sapiens_hsa04742	1.87694144
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.85464030
19	Morphine addiction_Homo sapiens_hsa05032	1.80711779
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.72169625
21	Olfactory transduction_Homo sapiens_hsa04740	1.60741089
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57401851
23	Homologous recombination_Homo sapiens_hsa03440	1.53932716
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51873269
25	Parkinsons disease_Homo sapiens_hsa05012	1.50830275
26	GABAergic synapse_Homo sapiens_hsa04727	1.49456566
27	Circadian entrainment_Homo sapiens_hsa04713	1.46628080
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.43401932
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.42896907
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.40586522
31	Insulin secretion_Homo sapiens_hsa04911	1.37302804
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.35167243
33	RNA polymerase_Homo sapiens_hsa03020	1.32351447
34	Caffeine metabolism_Homo sapiens_hsa00232	1.31949017
35	Basal transcription factors_Homo sapiens_hsa03022	1.27088842
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24914640
37	Serotonergic synapse_Homo sapiens_hsa04726	1.24194096
38	Protein export_Homo sapiens_hsa03060	1.22881297
39	ABC transporters_Homo sapiens_hsa02010	1.09634886
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04726665
41	Alzheimers disease_Homo sapiens_hsa05010	1.00391237
42	RNA degradation_Homo sapiens_hsa03018	1.00092083
43	Huntingtons disease_Homo sapiens_hsa05016	0.99886288
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.97172271
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96638562
46	Propanoate metabolism_Homo sapiens_hsa00640	0.94110791
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91837096
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91625822
49	Peroxisome_Homo sapiens_hsa04146	0.91420212
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91157360
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.90957984
52	Primary immunodeficiency_Homo sapiens_hsa05340	0.89700301
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89666910
54	Regulation of autophagy_Homo sapiens_hsa04140	0.89561435
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.88224045
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87235739
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86071747
58	Salivary secretion_Homo sapiens_hsa04970	0.84221834
59	Cholinergic synapse_Homo sapiens_hsa04725	0.83553952
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81765906
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79550672
62	Cocaine addiction_Homo sapiens_hsa05030	0.78930552
63	Retinol metabolism_Homo sapiens_hsa00830	0.77449524
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74236399
65	Amphetamine addiction_Homo sapiens_hsa05031	0.74067203
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73873983
67	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.71043307
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.68493470
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67912728
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67613378
71	One carbon pool by folate_Homo sapiens_hsa00670	0.66884472
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.61837594
73	Long-term depression_Homo sapiens_hsa04730	0.60528474
74	Renin secretion_Homo sapiens_hsa04924	0.59467998
75	cAMP signaling pathway_Homo sapiens_hsa04024	0.59454846
76	Histidine metabolism_Homo sapiens_hsa00340	0.58573140
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57936375
78	Asthma_Homo sapiens_hsa05310	0.55235923
79	Purine metabolism_Homo sapiens_hsa00230	0.53052843
80	Gastric acid secretion_Homo sapiens_hsa04971	0.51924066
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.51506255
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.51444259
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51059284
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49779599
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48220610
86	Metabolic pathways_Homo sapiens_hsa01100	0.43980197
87	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42223555
88	Mineral absorption_Homo sapiens_hsa04978	0.40199106
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.40132755
90	Axon guidance_Homo sapiens_hsa04360	0.39837478
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37968901
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37364658
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.35369536
94	Ribosome_Homo sapiens_hsa03010	0.34496120
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34261340
96	Circadian rhythm_Homo sapiens_hsa04710	0.31087036
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30828041
98	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.30480955
99	Sulfur relay system_Homo sapiens_hsa04122	0.29305411
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28516620

ZNF785

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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