ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.48007070
2	behavioral response to nicotine (GO:0035095)	4.76658481
3	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.35142971
4	pyrimidine nucleobase catabolic process (GO:0006208)	3.93413201
5	tachykinin receptor signaling pathway (GO:0007217)	3.57599223
6	fucose catabolic process (GO:0019317)	3.55921598
7	L-fucose metabolic process (GO:0042354)	3.55921598
8	L-fucose catabolic process (GO:0042355)	3.55921598
9	kynurenine metabolic process (GO:0070189)	3.53839358
10	indole-containing compound catabolic process (GO:0042436)	3.44821007
11	indolalkylamine catabolic process (GO:0046218)	3.44821007
12	tryptophan catabolic process (GO:0006569)	3.44821007
13	respiratory chain complex IV assembly (GO:0008535)	3.41732166
14	response to pheromone (GO:0019236)	3.37955219
15	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.36992787
16	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.36535206
17	replication fork processing (GO:0031297)	3.34111517
18	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.32973752
19	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.32973752
20	pseudouridine synthesis (GO:0001522)	3.26822138
21	nonmotile primary cilium assembly (GO:0035058)	3.19466332
22	tryptophan metabolic process (GO:0006568)	3.19018291
23	nucleobase catabolic process (GO:0046113)	3.13421382
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12497129
25	cytochrome complex assembly (GO:0017004)	3.12152148
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.10863890
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.10863890
28	NADH dehydrogenase complex assembly (GO:0010257)	3.10863890
29	piRNA metabolic process (GO:0034587)	3.10762955
30	indolalkylamine metabolic process (GO:0006586)	3.10258052
31	negative regulation of telomere maintenance (GO:0032205)	3.10075823
32	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.08882065
33	protein K11-linked deubiquitination (GO:0035871)	3.07173208
34	protein complex biogenesis (GO:0070271)	3.06085820
35	DNA deamination (GO:0045006)	3.05980458
36	DNA replication checkpoint (GO:0000076)	2.98237819
37	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.95336658
38	amine catabolic process (GO:0009310)	2.95324187
39	cellular biogenic amine catabolic process (GO:0042402)	2.95324187
40	mitochondrial RNA metabolic process (GO:0000959)	2.92131302
41	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90643666
42	platelet dense granule organization (GO:0060155)	2.90119108
43	negative regulation of mast cell activation (GO:0033004)	2.89523746
44	recombinational repair (GO:0000725)	2.89018222
45	base-excision repair, AP site formation (GO:0006285)	2.84521611
46	double-strand break repair via homologous recombination (GO:0000724)	2.84376420
47	protein polyglutamylation (GO:0018095)	2.83510844
48	peptidyl-histidine modification (GO:0018202)	2.80876860
49	head development (GO:0060322)	2.78720148
50	DNA-dependent DNA replication (GO:0006261)	2.77027259
51	reciprocal meiotic recombination (GO:0007131)	2.76120475
52	reciprocal DNA recombination (GO:0035825)	2.76120475
53	cornea development in camera-type eye (GO:0061303)	2.74202721
54	ubiquinone biosynthetic process (GO:0006744)	2.74116170
55	ubiquinone metabolic process (GO:0006743)	2.72388803
56	water-soluble vitamin biosynthetic process (GO:0042364)	2.70866671
57	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.69230402
58	regulation of cilium movement (GO:0003352)	2.67429830
59	tRNA processing (GO:0008033)	2.66673896
60	olfactory bulb development (GO:0021772)	2.65162318
61	regulation of mitochondrial translation (GO:0070129)	2.64909915
62	DNA methylation involved in gamete generation (GO:0043046)	2.64854791
63	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.64613848
64	regulation of mitotic spindle checkpoint (GO:1903504)	2.64613848
65	cilium morphogenesis (GO:0060271)	2.62057113
66	male meiosis I (GO:0007141)	2.61517939
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.61224861
68	neural tube formation (GO:0001841)	2.60778490
69	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.58928655
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.57375043
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.57375043
72	tRNA modification (GO:0006400)	2.56570056
73	anterograde synaptic vesicle transport (GO:0048490)	2.56124550
74	sex differentiation (GO:0007548)	2.56113384
75	protein localization to cilium (GO:0061512)	2.55612460
76	C-terminal protein amino acid modification (GO:0018410)	2.52950585
77	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.52767315
78	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.52194920
79	protein localization to synapse (GO:0035418)	2.49406442
80	regulation of collateral sprouting (GO:0048670)	2.49354811
81	atrial cardiac muscle cell action potential (GO:0086014)	2.49082329
82	regulation of action potential (GO:0098900)	2.48718517
83	regulation of telomere maintenance (GO:0032204)	2.48203722
84	translesion synthesis (GO:0019985)	2.47945249
85	positive regulation of prostaglandin secretion (GO:0032308)	2.46871839
86	detection of light stimulus involved in visual perception (GO:0050908)	2.46493056
87	detection of light stimulus involved in sensory perception (GO:0050962)	2.46493056
88	GPI anchor metabolic process (GO:0006505)	2.45626054
89	transmission of nerve impulse (GO:0019226)	2.45069837
90	opioid receptor signaling pathway (GO:0038003)	2.44669866
91	postreplication repair (GO:0006301)	2.44648778
92	transcription from mitochondrial promoter (GO:0006390)	2.44247772
93	synapsis (GO:0007129)	2.44226372
94	synaptic transmission, cholinergic (GO:0007271)	2.43960383
95	C-terminal protein lipidation (GO:0006501)	2.43553307
96	regulation of glucokinase activity (GO:0033131)	2.42730356
97	regulation of hexokinase activity (GO:1903299)	2.42730356
98	auditory receptor cell stereocilium organization (GO:0060088)	2.41828119
99	histone H2A acetylation (GO:0043968)	2.40093395
100	DNA catabolic process, exonucleolytic (GO:0000738)	2.39155804

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.43679371
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.52159462
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.18958818
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.02893370
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.79018392
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.77609129
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.73772254
8	VDR_22108803_ChIP-Seq_LS180_Human	2.68937978
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.67974791
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.66173286
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64562477
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.53514845
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.45546998
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.26727727
15	EWS_26573619_Chip-Seq_HEK293_Human	2.15814428
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.10194510
17	* MYC_18940864_ChIP-ChIP_HL60_Human	2.06981757
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05203227
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.03867541
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.99954358
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.91760420
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90438396
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.88796973
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.87498468
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.82246917
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82037492
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81076453
28	FUS_26573619_Chip-Seq_HEK293_Human	1.76757272
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.76309774
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.68302527
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67133807
32	P300_19829295_ChIP-Seq_ESCs_Human	1.65744384
33	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.63768203
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.60419384
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.58084110
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57838201
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53835218
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52592429
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.52064302
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50042258
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47797269
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46302410
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43941870
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.40048173
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37992307
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36265072
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.34190083
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.33872373
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27810117
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.27686576
51	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24930878
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21916852
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21916852
54	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21399480
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.21187544
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21187544
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.17245297
58	AR_25329375_ChIP-Seq_VCAP_Human	1.15830858
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.14451342
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14437698
61	EZH2_22144423_ChIP-Seq_EOC_Human	1.14344064
62	* NCOR_22424771_ChIP-Seq_293T_Human	1.13924824
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13476908
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12271704
65	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.11189167
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11041081
67	KDM5A_27292631_Chip-Seq_BREAST_Human	1.09103251
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09016932
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08656001
70	STAT3_23295773_ChIP-Seq_U87_Human	1.08150494
71	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.07848485
72	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07101396
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05963923
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05741343
75	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05543150
76	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.05334976
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04648711
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04648711
79	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.04555339
80	AR_20517297_ChIP-Seq_VCAP_Human	1.02799701
81	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01124233
82	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01124233
83	* TCF4_23295773_ChIP-Seq_U87_Human	0.99615781
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99247057
85	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99221749
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.97178442
87	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96754719
88	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96278514
89	RUNX2_22187159_ChIP-Seq_PCA_Human	0.95845695
90	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.94742917
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93650479
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92433550
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91971924
94	SMAD4_21799915_ChIP-Seq_A2780_Human	0.91480256
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.88541232
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.88063940
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.87959361
98	CIITA_25753668_ChIP-Seq_RAJI_Human	0.87849526
99	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.87011030
100	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.86286053

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.56299547
2	MP0006292_abnormal_olfactory_placode	3.39294095
3	MP0003787_abnormal_imprinting	2.78410108
4	MP0003195_calcinosis	2.48509000
5	MP0003121_genomic_imprinting	2.40338133
6	MP0002653_abnormal_ependyma_morphology	2.34409980
7	MP0005367_renal/urinary_system_phenotyp	2.18357651
8	MP0000516_abnormal_urinary_system	2.18357651
9	MP0008058_abnormal_DNA_repair	2.09267842
10	MP0005551_abnormal_eye_electrophysiolog	2.04136041
11	MP0006276_abnormal_autonomic_nervous	2.01761762
12	MP0003123_paternal_imprinting	2.00966442
13	MP0004133_heterotaxia	1.89533510
14	MP0003890_abnormal_embryonic-extraembry	1.87069706
15	MP0001968_abnormal_touch/_nociception	1.84187434
16	MP0005645_abnormal_hypothalamus_physiol	1.82074625
17	MP0000569_abnormal_digit_pigmentation	1.79684248
18	MP0002102_abnormal_ear_morphology	1.78273349
19	MP0001529_abnormal_vocalization	1.75642068
20	MP0006072_abnormal_retinal_apoptosis	1.75205066
21	MP0008789_abnormal_olfactory_epithelium	1.73373149
22	MP0003880_abnormal_central_pattern	1.68780401
23	MP0001986_abnormal_taste_sensitivity	1.60943449
24	MP0003718_maternal_effect	1.59499261
25	MP0002735_abnormal_chemical_nociception	1.58935681
26	MP0009046_muscle_twitch	1.58489177
27	MP0003693_abnormal_embryo_hatching	1.56905747
28	MP0003646_muscle_fatigue	1.56604305
29	MP0000778_abnormal_nervous_system	1.56026735
30	MP0010094_abnormal_chromosome_stability	1.54992833
31	MP0008872_abnormal_physiological_respon	1.53763036
32	MP0004742_abnormal_vestibular_system	1.51061174
33	MP0008057_abnormal_DNA_replication	1.50183149
34	MP0000372_irregular_coat_pigmentation	1.46095156
35	MP0000631_abnormal_neuroendocrine_gland	1.45401180
36	MP0005394_taste/olfaction_phenotype	1.43859262
37	MP0005499_abnormal_olfactory_system	1.43859262
38	MP0008995_early_reproductive_senescence	1.42735865
39	MP0009745_abnormal_behavioral_response	1.42728283
40	MP0002751_abnormal_autonomic_nervous	1.41037783
41	MP0005253_abnormal_eye_physiology	1.38534209
42	MP0004043_abnormal_pH_regulation	1.37894503
43	MP0003122_maternal_imprinting	1.34090534
44	MP0002138_abnormal_hepatobiliary_system	1.32751064
45	MP0002938_white_spotting	1.30002720
46	MP0002822_catalepsy	1.28595812
47	MP0002163_abnormal_gland_morphology	1.27938733
48	MP0005646_abnormal_pituitary_gland	1.26694655
49	MP0004142_abnormal_muscle_tone	1.26291321
50	MP0000049_abnormal_middle_ear	1.24968483
51	MP0001485_abnormal_pinna_reflex	1.24881939
52	MP0000427_abnormal_hair_cycle	1.23891887
53	MP0002272_abnormal_nervous_system	1.11184926
54	MP0003567_abnormal_fetal_cardiomyocyte	1.10038622
55	MP0003119_abnormal_digestive_system	1.09799993
56	MP0005075_abnormal_melanosome_morpholog	1.09626380
57	MP0002254_reproductive_system_inflammat	1.09284879
58	MP0002234_abnormal_pharynx_morphology	1.08434989
59	MP0002210_abnormal_sex_determination	1.07957755
60	MP0002736_abnormal_nociception_after	1.06968806
61	MP0001970_abnormal_pain_threshold	1.06915725
62	MP0001486_abnormal_startle_reflex	1.06689051
63	MP0002837_dystrophic_cardiac_calcinosis	1.06666431
64	MP0001984_abnormal_olfaction	1.06639038
65	MP0002734_abnormal_mechanical_nocicepti	1.06547478
66	MP0002752_abnormal_somatic_nervous	1.06487769
67	MP0006035_abnormal_mitochondrial_morpho	1.05948899
68	MP0002557_abnormal_social/conspecific_i	1.03792172
69	MP0002277_abnormal_respiratory_mucosa	1.03432482
70	MP0010386_abnormal_urinary_bladder	1.03157313
71	MP0002572_abnormal_emotion/affect_behav	1.02927577
72	MP0005167_abnormal_blood-brain_barrier	1.00655338
73	MP0005195_abnormal_posterior_eye	1.00395563
74	MP0004885_abnormal_endolymph	1.00368859
75	MP0002067_abnormal_sensory_capabilities	0.99861696
76	MP0003136_yellow_coat_color	0.98024868
77	MP0002909_abnormal_adrenal_gland	0.97633189
78	MP0003786_premature_aging	0.97229457
79	MP0002638_abnormal_pupillary_reflex	0.97136385
80	MP0001929_abnormal_gametogenesis	0.96086517
81	MP0003698_abnormal_male_reproductive	0.95057581
82	MP0002160_abnormal_reproductive_system	0.93073453
83	MP0005084_abnormal_gallbladder_morpholo	0.92904525
84	MP0005386_behavior/neurological_phenoty	0.90628647
85	MP0004924_abnormal_behavior	0.90628647
86	MP0002090_abnormal_vision	0.89261726
87	MP0002733_abnormal_thermal_nociception	0.88141853
88	MP0000015_abnormal_ear_pigmentation	0.87705037
89	MP0001919_abnormal_reproductive_system	0.87235050
90	MP0002063_abnormal_learning/memory/cond	0.86572264
91	MP0002184_abnormal_innervation	0.86276357
92	MP0005389_reproductive_system_phenotype	0.86231610
93	MP0003635_abnormal_synaptic_transmissio	0.86166935
94	MP0000538_abnormal_urinary_bladder	0.85513884
95	MP0001324_abnormal_eye_pigmentation	0.85207914
96	MP0001145_abnormal_male_reproductive	0.84825245
97	MP0001764_abnormal_homeostasis	0.83073694
98	MP0002882_abnormal_neuron_morphology	0.82183369
99	MP0002064_seizures	0.81940647
100	MP0005310_abnormal_salivary_gland	0.81570816

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.21995844
2	Pancreatic fibrosis (HP:0100732)	3.90534466
3	Nephronophthisis (HP:0000090)	3.76434617
4	True hermaphroditism (HP:0010459)	3.72257059
5	Abnormality of midbrain morphology (HP:0002418)	3.69822232
6	Molar tooth sign on MRI (HP:0002419)	3.69822232
7	Pendular nystagmus (HP:0012043)	3.53361032
8	Abnormality of the renal medulla (HP:0100957)	3.07364848
9	Chronic hepatic failure (HP:0100626)	2.88656068
10	Colon cancer (HP:0003003)	2.85209678
11	Medial flaring of the eyebrow (HP:0010747)	2.80917398
12	Type II lissencephaly (HP:0007260)	2.77211457
13	Lissencephaly (HP:0001339)	2.76374654
14	Abnormality of the labia minora (HP:0012880)	2.74581207
15	Congenital stationary night blindness (HP:0007642)	2.68343163
16	Cystic liver disease (HP:0006706)	2.65244628
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.62224366
18	Sclerocornea (HP:0000647)	2.59064443
19	Anencephaly (HP:0002323)	2.57386397
20	Gait imbalance (HP:0002141)	2.50323016
21	3-Methylglutaconic aciduria (HP:0003535)	2.49426479
22	Nephrogenic diabetes insipidus (HP:0009806)	2.47992670
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.47495158
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.44933460
25	Abolished electroretinogram (ERG) (HP:0000550)	2.44636662
26	Congenital primary aphakia (HP:0007707)	2.40618453
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.38285774
28	Abnormality of alanine metabolism (HP:0010916)	2.38285774
29	Hyperalaninemia (HP:0003348)	2.38285774
30	Broad-based gait (HP:0002136)	2.38164641
31	Abnormality of the renal cortex (HP:0011035)	2.37652850
32	Progressive inability to walk (HP:0002505)	2.37069716
33	Tubular atrophy (HP:0000092)	2.36941570
34	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.36867364
35	Abnormal biliary tract physiology (HP:0012439)	2.28127094
36	Bile duct proliferation (HP:0001408)	2.28127094
37	Inability to walk (HP:0002540)	2.27543951
38	Increased CSF lactate (HP:0002490)	2.17193339
39	Ectopic kidney (HP:0000086)	2.16901990
40	Cerebellar dysplasia (HP:0007033)	2.15137071
41	Furrowed tongue (HP:0000221)	2.13910418
42	Acute necrotizing encephalopathy (HP:0006965)	2.13721917
43	Male pseudohermaphroditism (HP:0000037)	2.12452915
44	Congenital hepatic fibrosis (HP:0002612)	2.11488536
45	Occipital encephalocele (HP:0002085)	2.11187168
46	Acute encephalopathy (HP:0006846)	2.10256500
47	Mitochondrial inheritance (HP:0001427)	2.10151973
48	Neoplasm of the adrenal cortex (HP:0100641)	2.09874794
49	Retinal dysplasia (HP:0007973)	2.05115887
50	Agitation (HP:0000713)	2.04735509
51	Preaxial hand polydactyly (HP:0001177)	2.03250770
52	Pachygyria (HP:0001302)	2.02241278
53	Intestinal atresia (HP:0011100)	2.00900294
54	Attenuation of retinal blood vessels (HP:0007843)	1.98180113
55	Drooling (HP:0002307)	1.95979241
56	Abnormality of the ileum (HP:0001549)	1.94897081
57	Meckel diverticulum (HP:0002245)	1.94350714
58	Sloping forehead (HP:0000340)	1.94185882
59	Renal cortical cysts (HP:0000803)	1.92959509
60	Progressive macrocephaly (HP:0004481)	1.92868135
61	Genital tract atresia (HP:0001827)	1.91707654
62	Clumsiness (HP:0002312)	1.89904377
63	Hyperglycinemia (HP:0002154)	1.89171742
64	Increased serum lactate (HP:0002151)	1.88878204
65	Protruding tongue (HP:0010808)	1.88431396
66	Large for gestational age (HP:0001520)	1.86495131
67	Vaginal atresia (HP:0000148)	1.86191500
68	Hyperventilation (HP:0002883)	1.85957190
69	Hepatocellular necrosis (HP:0001404)	1.85762606
70	Abnormality of chromosome stability (HP:0003220)	1.85566154
71	Absent speech (HP:0001344)	1.84482219
72	Tubulointerstitial nephritis (HP:0001970)	1.84299086
73	Oligodactyly (hands) (HP:0001180)	1.84019206
74	Postaxial foot polydactyly (HP:0001830)	1.82871990
75	Narrow forehead (HP:0000341)	1.82736765
76	Chorioretinal atrophy (HP:0000533)	1.82186428
77	Ependymoma (HP:0002888)	1.80710827
78	Patellar aplasia (HP:0006443)	1.80014643
79	Hyperglycinuria (HP:0003108)	1.79947375
80	Poor coordination (HP:0002370)	1.79447597
81	Excessive salivation (HP:0003781)	1.79006977
82	Abnormal mitochondria in muscle tissue (HP:0008316)	1.77129140
83	Lipid accumulation in hepatocytes (HP:0006561)	1.76890775
84	Dandy-Walker malformation (HP:0001305)	1.75836451
85	Absent thumb (HP:0009777)	1.73558650
86	Polymicrogyria (HP:0002126)	1.73543018
87	Fair hair (HP:0002286)	1.72272638
88	Oligohydramnios (HP:0001562)	1.72009117
89	Hepatic necrosis (HP:0002605)	1.70254920
90	Aplasia/Hypoplasia of the patella (HP:0006498)	1.69712757
91	Oculomotor apraxia (HP:0000657)	1.69469801
92	Astigmatism (HP:0000483)	1.69424292
93	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.69168508
94	Optic disc pallor (HP:0000543)	1.69087176
95	Horseshoe kidney (HP:0000085)	1.68773911
96	Stomach cancer (HP:0012126)	1.67820207
97	Increased hepatocellular lipid droplets (HP:0006565)	1.66322296
98	Chromsome breakage (HP:0040012)	1.65714841
99	Adrenal hypoplasia (HP:0000835)	1.65012601
100	Gaze-evoked nystagmus (HP:0000640)	1.64728418

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.82598785
2	BMPR1B	3.95217952
3	NUAK1	3.13970842
4	WNK3	2.98492634
5	ADRBK2	2.81496100
6	CASK	2.74858722
7	TRIM28	2.50467728
8	ZAK	2.48859858
9	ACVR1B	2.26058206
10	MAPK13	2.21729182
11	TNIK	2.14029541
12	GRK1	2.13683297
13	BCKDK	1.96587314
14	MAP2K7	1.86718079
15	STK16	1.77107121
16	VRK2	1.67998178
17	INSRR	1.64580761
18	TIE1	1.55306567
19	BCR	1.53882354
20	MAP3K4	1.49569863
21	CSNK1G3	1.47176596
22	PINK1	1.44653684
23	CSNK1G2	1.44005535
24	CSNK1G1	1.40562932
25	MAP4K2	1.36904361
26	MKNK2	1.35350937
27	PAK3	1.35169138
28	TAOK3	1.34566159
29	CSNK1A1L	1.33893956
30	EIF2AK3	1.32055169
31	TLK1	1.30798217
32	DYRK2	1.29647527
33	STK38L	1.18188502
34	MARK1	1.17302173
35	TGFBR1	1.16669493
36	DAPK2	1.13689384
37	CDC7	1.11605367
38	PASK	1.07808126
39	SIK2	1.00368475
40	TXK	0.99634914
41	FGFR2	0.97592337
42	CAMK1D	0.95041320
43	VRK1	0.91876732
44	ATR	0.90902726
45	ERBB3	0.90455214
46	SRPK1	0.88552359
47	MUSK	0.87136379
48	PLK3	0.85628341
49	MAPKAPK3	0.84616826
50	PRKCG	0.81844185
51	WNK4	0.79365142
52	STK3	0.77341948
53	CAMKK2	0.74669092
54	PRKCE	0.73976089
55	PLK4	0.73603203
56	ADRBK1	0.73417850
57	PLK2	0.72861883
58	NTRK2	0.71891326
59	CHEK2	0.71527886
60	PLK1	0.70478782
61	TNK2	0.70060834
62	PHKG1	0.68505786
63	PHKG2	0.68505786
64	IRAK1	0.66735666
65	MKNK1	0.64079892
66	CSNK1A1	0.62934031
67	PRKCI	0.61787602
68	SIK3	0.61707699
69	TEC	0.61092694
70	OXSR1	0.58633011
71	NLK	0.58079572
72	PRKCZ	0.57478778
73	IKBKB	0.56888041
74	STK39	0.55356326
75	ATM	0.54660526
76	NEK2	0.54160139
77	CHUK	0.53831115
78	NTRK3	0.51802457
79	NME1	0.50495345
80	RPS6KA4	0.49090361
81	CAMKK1	0.48541928
82	MATK	0.47166936
83	CSNK1D	0.47069955
84	EPHA4	0.45913520
85	DAPK1	0.45380324
86	PRKCQ	0.41389993
87	STK11	0.41121668
88	FER	0.39708992
89	LATS1	0.36935726
90	CAMK1G	0.35899544
91	CAMK4	0.35703723
92	ITK	0.34934303
93	CSNK1E	0.34441787
94	RPS6KA5	0.34150264
95	DYRK3	0.29106804
96	WEE1	0.29026972
97	STK24	0.28703083
98	PRKACA	0.28626231
99	PRKAA1	0.27657707
100	CSNK2A1	0.27165018

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.94869793
2	Homologous recombination_Homo sapiens_hsa03440	2.91132431
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.82071622
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.75352258
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.68565405
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.64770683
7	RNA polymerase_Homo sapiens_hsa03020	2.49959457
8	Basal transcription factors_Homo sapiens_hsa03022	2.44363511
9	Phototransduction_Homo sapiens_hsa04744	2.38628346
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.23770154
11	Protein export_Homo sapiens_hsa03060	2.21236627
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.15596770
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10257042
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.07832286
15	RNA degradation_Homo sapiens_hsa03018	2.00296189
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.95949695
17	Butanoate metabolism_Homo sapiens_hsa00650	1.87677892
18	Base excision repair_Homo sapiens_hsa03410	1.66661176
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.66082080
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65399275
21	One carbon pool by folate_Homo sapiens_hsa00670	1.64998475
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.63306319
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63102275
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63081087
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62657112
26	Parkinsons disease_Homo sapiens_hsa05012	1.60261895
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.56103186
28	Nicotine addiction_Homo sapiens_hsa05033	1.55772164
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.54549073
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.52874546
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49100093
32	Proteasome_Homo sapiens_hsa03050	1.48046275
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.47633707
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.46956949
35	RNA transport_Homo sapiens_hsa03013	1.46714759
36	Spliceosome_Homo sapiens_hsa03040	1.39423714
37	Peroxisome_Homo sapiens_hsa04146	1.39188287
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.38556189
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38317340
40	Propanoate metabolism_Homo sapiens_hsa00640	1.29990071
41	Regulation of autophagy_Homo sapiens_hsa04140	1.21610242
42	Mismatch repair_Homo sapiens_hsa03430	1.21184282
43	Sulfur relay system_Homo sapiens_hsa04122	1.16499008
44	Taste transduction_Homo sapiens_hsa04742	1.07823132
45	Huntingtons disease_Homo sapiens_hsa05016	1.05345947
46	DNA replication_Homo sapiens_hsa03030	1.02705112
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.00410607
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97659112
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.96380995
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93208661
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.92307766
52	Primary immunodeficiency_Homo sapiens_hsa05340	0.91813968
53	Folate biosynthesis_Homo sapiens_hsa00790	0.90543358
54	Purine metabolism_Homo sapiens_hsa00230	0.88592003
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83531253
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76716508
57	Metabolic pathways_Homo sapiens_hsa01100	0.74347029
58	Morphine addiction_Homo sapiens_hsa05032	0.74005250
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73201931
60	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.71615535
61	Sphingolipid metabolism_Homo sapiens_hsa00600	0.69790685
62	Alzheimers disease_Homo sapiens_hsa05010	0.69018305
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.68527501
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65418001
65	Caffeine metabolism_Homo sapiens_hsa00232	0.64434934
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.64047867
67	Fatty acid elongation_Homo sapiens_hsa00062	0.62606156
68	Nitrogen metabolism_Homo sapiens_hsa00910	0.58336182
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55672448
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54356747
71	Long-term depression_Homo sapiens_hsa04730	0.53798281
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53775571
73	Insulin secretion_Homo sapiens_hsa04911	0.53313091
74	GABAergic synapse_Homo sapiens_hsa04727	0.51506316
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48422335
76	p53 signaling pathway_Homo sapiens_hsa04115	0.47985465
77	Serotonergic synapse_Homo sapiens_hsa04726	0.47591899
78	ABC transporters_Homo sapiens_hsa02010	0.46302339
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46115443
80	Oocyte meiosis_Homo sapiens_hsa04114	0.45540961
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43920266
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43778562
83	Olfactory transduction_Homo sapiens_hsa04740	0.43223784
84	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.41973922
85	Lysine degradation_Homo sapiens_hsa00310	0.40521467
86	Sulfur metabolism_Homo sapiens_hsa00920	0.40077217
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.38668242
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.36162735
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35977542
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.34579197
91	Cell cycle_Homo sapiens_hsa04110	0.34474534
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33394012
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.32582488
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.31171356
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.31121009
96	Axon guidance_Homo sapiens_hsa04360	0.30389344
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.25183671
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23744860
99	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.23045957
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.21868998

ZNF786

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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