ZNF787

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.84914280
2response to peptidoglycan (GO:0032494)4.19993270
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.10290076
4protein localization to endosome (GO:0036010)3.75901801
5apoptotic process involved in morphogenesis (GO:0060561)3.66871654
6pentose-phosphate shunt (GO:0006098)3.52042846
7positive regulation of Cdc42 GTPase activity (GO:0043089)3.50675214
8regulation of early endosome to late endosome transport (GO:2000641)3.49070848
9ribosomal small subunit biogenesis (GO:0042274)3.46898373
103-UTR-mediated mRNA stabilization (GO:0070935)3.46281582
11regulation of mammary gland epithelial cell proliferation (GO:0033599)3.45894579
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41828927
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41828927
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.41828927
15modulation by symbiont of host immune response (GO:0052553)3.41828927
16positive regulation by symbiont of host defense response (GO:0052509)3.41828927
17modulation by symbiont of host defense response (GO:0052031)3.41828927
18modulation by symbiont of host cellular process (GO:0044068)3.38891382
19mannose metabolic process (GO:0006013)3.26941257
20modulation by virus of host process (GO:0019054)3.26437461
21pinocytosis (GO:0006907)3.23783672
22maternal placenta development (GO:0001893)3.18526566
23positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08322166
24glucose catabolic process (GO:0006007)3.04904509
25activation of Rac GTPase activity (GO:0032863)3.01499000
26NIK/NF-kappaB signaling (GO:0038061)2.98364335
27activation of MAPKKK activity (GO:0000185)2.98339486
28NADPH regeneration (GO:0006740)2.95242611
29cellular response to virus (GO:0098586)2.94376066
30response to muramyl dipeptide (GO:0032495)2.92557455
31glucose 6-phosphate metabolic process (GO:0051156)2.91870435
32lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90014041
33negative regulation of cell size (GO:0045792)2.80706191
34adherens junction assembly (GO:0034333)2.80212625
35focal adhesion assembly (GO:0048041)2.78590410
36cell-substrate adherens junction assembly (GO:0007045)2.78590410
37regulation of glucose import in response to insulin stimulus (GO:2001273)2.77718579
38embryonic process involved in female pregnancy (GO:0060136)2.77650929
39proline biosynthetic process (GO:0006561)2.76041547
40negative regulation of viral release from host cell (GO:1902187)2.75483174
41stress fiber assembly (GO:0043149)2.74033018
42response to laminar fluid shear stress (GO:0034616)2.71236876
43negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.71189152
44intracellular estrogen receptor signaling pathway (GO:0030520)2.70917269
45regulation of superoxide anion generation (GO:0032928)2.70420917
46epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70287247
47detection of other organism (GO:0098543)2.68481229
48positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.68461609
49macrophage activation involved in immune response (GO:0002281)2.67943974
50pentose metabolic process (GO:0019321)2.67595282
51detection of bacterium (GO:0016045)2.65978517
52neutrophil activation involved in immune response (GO:0002283)2.64000654
53positive regulation of histone deacetylation (GO:0031065)2.63561581
54regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60940857
55viral transcription (GO:0019083)2.60603488
56regulation of leukocyte degranulation (GO:0043300)2.59464666
57barbed-end actin filament capping (GO:0051016)2.58037364
58positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.57681749
59regulation of chromatin binding (GO:0035561)2.57108452
60heterochromatin organization (GO:0070828)2.55581215
61regulation of apoptotic process involved in morphogenesis (GO:1902337)2.54117735
62cell-cell junction maintenance (GO:0045217)2.52668414
63negative regulation of necroptotic process (GO:0060546)2.51906558
64regulation of necrotic cell death (GO:0010939)2.44233651
65mRNA stabilization (GO:0048255)2.43298230
66RNA stabilization (GO:0043489)2.43298230
67negative regulation of interleukin-12 production (GO:0032695)2.43195110
68negative regulation of toll-like receptor signaling pathway (GO:0034122)2.39861297
69protein retention in ER lumen (GO:0006621)2.37549207
70regulation of interferon-beta biosynthetic process (GO:0045357)2.37543967
71regulation of myeloid leukocyte mediated immunity (GO:0002886)2.37223390
72negative regulation of fatty acid transport (GO:2000192)2.34890239
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.34748003
74positive regulation of gamma-delta T cell activation (GO:0046645)2.33912879
75regulation of mast cell degranulation (GO:0043304)2.33339598
76glycosphingolipid catabolic process (GO:0046479)2.33246368
77negative regulation of myeloid cell apoptotic process (GO:0033033)2.32566083
78apoptotic process involved in development (GO:1902742)2.32043803
79modulation by virus of host morphology or physiology (GO:0019048)2.31365386
80endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.30829870
81negative regulation of cell killing (GO:0031342)2.29994668
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.29994668
83regulation of necroptotic process (GO:0060544)2.29872878
84detection of external biotic stimulus (GO:0098581)2.28635834
85low-density lipoprotein particle clearance (GO:0034383)2.26780585
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.24895441
87response to host (GO:0075136)2.24895441
88response to host defenses (GO:0052200)2.24895441
89germinal center formation (GO:0002467)2.24232013
90leukocyte aggregation (GO:0070486)2.23106637
91positive regulation of protein deacetylation (GO:0090312)2.21254548
92COPI coating of Golgi vesicle (GO:0048205)2.20562100
93Golgi transport vesicle coating (GO:0048200)2.20562100
94peptidyl-arginine omega-N-methylation (GO:0035247)2.20456920
95translational termination (GO:0006415)2.20070546
96regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.19929638
97regulation of NFAT protein import into nucleus (GO:0051532)2.19761728
98response to host immune response (GO:0052572)2.19493018
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.19493018
100intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.18973456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.28609180
2* MYC_22102868_ChIP-Seq_BL_Human2.93779761
3LXR_22292898_ChIP-Seq_THP-1_Human2.68558731
4* ELK3_25401928_ChIP-Seq_HUVEC_Human2.47704466
5* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40559621
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36908716
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35137789
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30215728
9* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.27459799
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.26829405
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.23710743
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21857633
13RACK7_27058665_Chip-Seq_MCF-7_Human2.12861335
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10845706
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07090237
16KDM2B_26808549_Chip-Seq_DND41_Human2.05430511
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03861491
18TCF7_22412390_ChIP-Seq_EML_Mouse2.03752773
19VDR_24763502_ChIP-Seq_THP-1_Human1.90073413
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.89440279
21ZNF263_19887448_ChIP-Seq_K562_Human1.84094636
22* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63565120
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62704739
24KDM2B_26808549_Chip-Seq_K562_Human1.60267444
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58661268
26MAF_26560356_Chip-Seq_TH1_Human1.58073300
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.56753979
28P68_20966046_ChIP-Seq_HELA_Human1.54007562
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48456372
30SA1_27219007_Chip-Seq_ERYTHROID_Human1.47490241
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47369412
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46984247
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45500512
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42706537
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41971237
36MAF_26560356_Chip-Seq_TH2_Human1.40901772
37UTX_26944678_Chip-Seq_JUKART_Human1.39877464
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.39679610
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39553529
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.38446517
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37218268
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36863651
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36047653
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34996731
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34754538
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34522620
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.32062841
48NCOR1_26117541_ChIP-Seq_K562_Human1.31808492
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.29109234
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27631092
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.26472807
52* ELF1_20517297_ChIP-Seq_JURKAT_Human1.23479159
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23425026
54CREB1_26743006_Chip-Seq_LNCaP_Human1.23030170
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22970943
56ATF3_27146783_Chip-Seq_COLON_Human1.22438795
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22415244
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21580340
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21189042
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20762323
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20218057
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19927991
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19474624
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19308623
65SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18731296
66SMC4_20622854_ChIP-Seq_HELA_Human1.18227870
67BCOR_27268052_Chip-Seq_Bcells_Human1.18120691
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15557117
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15338715
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15117802
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15034844
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.14148878
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13679432
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13028043
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12650501
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11941823
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.11685858
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11524464
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10873807
80E2F7_22180533_ChIP-Seq_HELA_Human1.10419292
81BCL6_27268052_Chip-Seq_Bcells_Human1.08383719
82XRN2_22483619_ChIP-Seq_HELA_Human1.08317249
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08268794
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07836964
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07019426
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06623681
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06300017
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05224973
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05224593
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04535537
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04515993
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04011642
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03959826
94CTCF_26484167_Chip-Seq_Bcells_Mouse1.03740436
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02340076
96PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02202243
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00657826
98MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99621976
99CTCF_21964334_Chip-Seq_Bcells_Human0.99392614
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.98650122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.95224075
2MP0003705_abnormal_hypodermis_morpholog3.55478254
3MP0005058_abnormal_lysosome_morphology3.31018489
4MP0003303_peritoneal_inflammation3.24985772
5MP0005076_abnormal_cell_differentiation2.82545117
6MP0003436_decreased_susceptibility_to2.78421632
7MP0009840_abnormal_foam_cell2.65619816
8MP0009278_abnormal_bone_marrow2.50326572
9MP0008260_abnormal_autophagy2.42148334
10MP0004185_abnormal_adipocyte_glucose2.41799264
11MP0004858_abnormal_nervous_system2.11495131
12MP0003191_abnormal_cellular_cholesterol2.03424823
13MP0003172_abnormal_lysosome_physiology1.97922815
14MP0003453_abnormal_keratinocyte_physiol1.97623025
15MP0004510_myositis1.94829659
16MP0001849_ear_inflammation1.93693103
17MP0003300_gastrointestinal_ulcer1.93316870
18MP0002877_abnormal_melanocyte_morpholog1.89309177
19MP0000858_altered_metastatic_potential1.73421418
20MP0004947_skin_inflammation1.67714747
21MP0002419_abnormal_innate_immunity1.63480685
22MP0009333_abnormal_splenocyte_physiolog1.60834096
23MP0000678_abnormal_parathyroid_gland1.59733709
24MP0005666_abnormal_adipose_tissue1.58586185
25MP0005025_abnormal_response_to1.58191864
26MP0003566_abnormal_cell_adhesion1.52678341
27MP0000685_abnormal_immune_system1.44305659
28MP0010234_abnormal_vibrissa_follicle1.44041257
29MP0005464_abnormal_platelet_physiology1.41698850
30MP0009379_abnormal_foot_pigmentation1.31794552
31MP0002249_abnormal_larynx_morphology1.31229420
32MP0005000_abnormal_immune_tolerance1.31045709
33MP0004808_abnormal_hematopoietic_stem1.28315634
34MP0002796_impaired_skin_barrier1.25611924
35MP0001533_abnormal_skeleton_physiology1.25439716
36MP0002998_abnormal_bone_remodeling1.24766980
37MP0001545_abnormal_hematopoietic_system1.24746849
38MP0005397_hematopoietic_system_phenotyp1.24746849
39MP0009785_altered_susceptibility_to1.23231500
40MP0003091_abnormal_cell_migration1.22530960
41MP0002089_abnormal_postnatal_growth/wei1.22460572
42MP0000490_abnormal_crypts_of1.21736200
43MP0005387_immune_system_phenotype1.21270734
44MP0001790_abnormal_immune_system1.21270734
45MP0005375_adipose_tissue_phenotype1.20793950
46MP0002396_abnormal_hematopoietic_system1.20483950
47MP0000750_abnormal_muscle_regeneration1.20141887
48MP0002148_abnormal_hypersensitivity_rea1.19005993
49MP0003075_altered_response_to1.17038382
50MP0002452_abnormal_antigen_presenting1.15392625
51MP0003123_paternal_imprinting1.15116848
52MP0001819_abnormal_immune_cell1.13696903
53MP0002420_abnormal_adaptive_immunity1.13385555
54MP0002723_abnormal_immune_serum1.13313220
55MP0000747_muscle_weakness1.12500542
56MP0005409_darkened_coat_color1.12141958
57MP0004233_abnormal_muscle_weight1.11548290
58MP0001835_abnormal_antigen_presentation1.11473171
59MP0005501_abnormal_skin_physiology1.09103122
60MP0000733_abnormal_muscle_development1.08827374
61MP0003828_pulmonary_edema1.07158724
62MP0010155_abnormal_intestine_physiology1.05691487
63MP0000343_altered_response_to1.05352655
64MP0002398_abnormal_bone_marrow1.03957436
65MP0001800_abnormal_humoral_immune1.03288087
66MP0001730_embryonic_growth_arrest1.03101216
67MP0000537_abnormal_urethra_morphology1.02363119
68MP0001853_heart_inflammation1.01617533
69MP0003763_abnormal_thymus_physiology1.01189138
70MP0002254_reproductive_system_inflammat1.00200305
71MP0000716_abnormal_immune_system0.95013098
72MP0002429_abnormal_blood_cell0.94307964
73MP0001845_abnormal_inflammatory_respons0.93547713
74MP0009672_abnormal_birth_weight0.93215521
75MP0002405_respiratory_system_inflammati0.91198438
76MP0002722_abnormal_immune_system0.89591570
77MP0001873_stomach_inflammation0.89147673
78MP0000703_abnormal_thymus_morphology0.86838815
79MP0008469_abnormal_protein_level0.86059576
80MP0005023_abnormal_wound_healing0.85970827
81MP0010030_abnormal_orbit_morphology0.85661874
82MP0002132_abnormal_respiratory_system0.84699897
83MP0003111_abnormal_nucleus_morphology0.83182443
84MP0002139_abnormal_hepatobiliary_system0.83039487
85MP0003724_increased_susceptibility_to0.82947932
86MP0003329_amyloid_beta_deposits0.82856853
87MP0000759_abnormal_skeletal_muscle0.82723941
88MP0009931_abnormal_skin_appearance0.82586039
89MP0005257_abnormal_intraocular_pressure0.82584222
90MP0010630_abnormal_cardiac_muscle0.80177866
91MP0000604_amyloidosis0.79921176
92MP0005621_abnormal_cell_physiology0.79537391
93MP0006082_CNS_inflammation0.79157330
94MP0005390_skeleton_phenotype0.78009564
95MP0000313_abnormal_cell_death0.76356994
96MP0003806_abnormal_nucleotide_metabolis0.74749833
97MP0003279_aneurysm0.74218400
98MP0001915_intracranial_hemorrhage0.73459441
99MP0000681_abnormal_thyroid_gland0.73155019
100MP0000689_abnormal_spleen_morphology0.73121377

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.21818499
2Achilles tendon contracture (HP:0001771)3.15202048
3Distal lower limb amyotrophy (HP:0008944)3.00009874
4Hyperacusis (HP:0010780)2.94206013
5Distal lower limb muscle weakness (HP:0009053)2.93147055
6Increased connective tissue (HP:0009025)2.91600456
7Abnormality of the Achilles tendon (HP:0005109)2.88396003
8Abnormality of macrophages (HP:0004311)2.87445515
9Increased cerebral lipofuscin (HP:0011813)2.75486568
10Cellulitis (HP:0100658)2.75002090
11Centrally nucleated skeletal muscle fibers (HP:0003687)2.72944274
12Recurrent abscess formation (HP:0002722)2.69481399
13Recurrent bacterial skin infections (HP:0005406)2.62661689
14Chronic obstructive pulmonary disease (HP:0006510)2.53735144
15Obstructive lung disease (HP:0006536)2.53735144
16Ulnar bowing (HP:0003031)2.53559489
17Vertebral compression fractures (HP:0002953)2.47257132
18Increased neuronal autofluorescent lipopigment (HP:0002074)2.43164293
19Myopathic facies (HP:0002058)2.37349770
20Polygenic inheritance (HP:0010982)2.36008705
21Broad face (HP:0000283)2.33579069
22Abnormality of liposaccharide metabolism (HP:0010968)2.28085045
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.28085045
24Abnormality of glycolipid metabolism (HP:0010969)2.28085045
25Abnormality of the thoracic spine (HP:0100711)2.27531121
26Bulbar palsy (HP:0001283)2.26183108
27Disproportionate tall stature (HP:0001519)2.21565757
28Colitis (HP:0002583)2.20519650
29Mediastinal lymphadenopathy (HP:0100721)2.19121207
30Stridor (HP:0010307)2.18735188
31Thoracic kyphosis (HP:0002942)2.18323468
32Increased serum ferritin (HP:0003281)2.17104715
33Long palpebral fissure (HP:0000637)2.14747003
34Deep venous thrombosis (HP:0002625)2.13402170
35Progressive muscle weakness (HP:0003323)2.13197381
36Axonal loss (HP:0003447)2.12936984
37Obstructive sleep apnea (HP:0002870)2.10665126
38Broad distal phalanx of finger (HP:0009836)2.10593616
39Hypertensive crisis (HP:0100735)2.10285458
40Hemorrhage of the eye (HP:0011885)2.10116312
41Difficulty climbing stairs (HP:0003551)2.09692145
42Flat acetabular roof (HP:0003180)2.07145190
43Thin bony cortex (HP:0002753)2.06852093
44Dysostosis multiplex (HP:0000943)2.06017311
45Reticulocytosis (HP:0001923)2.04881460
46Gingivitis (HP:0000230)2.04244756
47Abnormality of skeletal muscle fiber size (HP:0012084)2.03562017
48Recurrent gram-negative bacterial infections (HP:0005420)2.02831345
49Increased variability in muscle fiber diameter (HP:0003557)2.01563149
50Loss of speech (HP:0002371)1.99051892
51Cerebral aneurysm (HP:0004944)1.97568153
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97505176
53Hypertriglyceridemia (HP:0002155)1.91031755
54Distal upper limb amyotrophy (HP:0007149)1.90865251
55Upper limb amyotrophy (HP:0009129)1.90865251
56Ragged-red muscle fibers (HP:0003200)1.90497307
57Gastrointestinal inflammation (HP:0004386)1.87835439
58Deep palmar crease (HP:0006191)1.86624075
59Cholecystitis (HP:0001082)1.85533242
60Abnormal gallbladder physiology (HP:0012438)1.85533242
61Short nail (HP:0001799)1.84070785
62Myocardial infarction (HP:0001658)1.83822484
63Segmental peripheral demyelination/remyelination (HP:0003481)1.83117203
64Systemic lupus erythematosus (HP:0002725)1.82751817
65Increased IgE level (HP:0003212)1.82241637
66Lower limb amyotrophy (HP:0007210)1.81555046
67Upper motor neuron abnormality (HP:0002127)1.79809251
68Purpura (HP:0000979)1.79675548
69Easy fatigability (HP:0003388)1.76924839
70Mitral regurgitation (HP:0001653)1.76538012
71Pathologic fracture (HP:0002756)1.76442328
72Trismus (HP:0000211)1.75514618
73Bone pain (HP:0002653)1.75059467
74Generalized amyotrophy (HP:0003700)1.74608635
75Fragile skin (HP:0001030)1.73870569
76Abnormality of the distal phalanges of the toes (HP:0010182)1.72618405
77Protrusio acetabuli (HP:0003179)1.70886326
78Nuclear cataract (HP:0100018)1.69047832
79Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68533901
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67904567
81Diaphragmatic weakness (HP:0009113)1.67847140
82Polycythemia (HP:0001901)1.67503136
83Abnormality of reticulocytes (HP:0004312)1.67391401
84Hyperparathyroidism (HP:0000843)1.66461328
85Myositis (HP:0100614)1.63973163
86Cerebral inclusion bodies (HP:0100314)1.63812141
87Exercise-induced myalgia (HP:0003738)1.60719869
88Interstitial pulmonary disease (HP:0006530)1.60715681
89Petechiae (HP:0000967)1.60547898
90Truncus arteriosus (HP:0001660)1.59106535
91Metaphyseal cupping (HP:0003021)1.58717390
92Gastrointestinal stroma tumor (HP:0100723)1.58244694
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.58233764
94J-shaped sella turcica (HP:0002680)1.58102084
95Genu recurvatum (HP:0002816)1.58044481
96Meningitis (HP:0001287)1.57592473
97Abnormal vertebral ossification (HP:0100569)1.56706033
98Inflammation of the large intestine (HP:0002037)1.55517414
99Blue sclerae (HP:0000592)1.55003008
100Premature rupture of membranes (HP:0001788)1.54983860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.92728533
2SMG13.65336005
3IRAK33.64312420
4PRPF4B3.34322726
5NME23.11264226
6ERN12.97524534
7SIK12.92044019
8ICK2.39187767
9MAP2K32.13691781
10EEF2K2.04225639
11MAP3K112.03462412
12TAOK21.90805692
13MAP3K101.87778808
14IRAK41.86240305
15TTN1.84123723
16EPHA21.73040490
17MAP4K11.72698722
18CDK121.55982285
19TAOK11.53907014
20IRAK21.48834321
21RIPK11.45325934
22RIPK41.39021436
23MAP3K31.35509954
24PKN21.30827165
25ARAF1.24714811
26TBK11.19173407
27BRAF1.18030046
28PTK61.17928069
29MAP3K11.16942193
30FGFR41.12695206
31EPHB11.12202932
32PAK41.10425411
33MAP3K131.06092406
34MARK21.03391489
35TESK21.01526545
36PDPK10.93570504
37MST1R0.92640596
38MAP3K80.90091276
39PRKD20.89864409
40MTOR0.89261203
41TYK20.88383419
42RPS6KC10.86171957
43RPS6KL10.86171957
44BMX0.85026261
45CDC42BPA0.84407736
46LRRK20.82376065
47MAP2K20.82047979
48CSK0.80491121
49KSR20.79959529
50RPS6KA20.79584937
51LMTK20.78934800
52BLK0.78433711
53RPS6KB20.78371850
54HIPK20.76742912
55MAP3K140.71985499
56ZAP700.71617194
57GRK60.71357902
58TESK10.70133072
59CDK40.69337647
60TNK20.68671552
61PIM20.68277800
62PRKG20.67923648
63ILK0.65079325
64MAPK110.62196946
65RPS6KA60.61967536
66BTK0.61267626
67CAMK1D0.57551533
68PDGFRA0.55177673
69DMPK0.55060588
70MOS0.54937732
71PTK20.53600096
72MATK0.53480461
73IRAK10.53474936
74CDK70.51998615
75LATS20.51682179
76IKBKB0.50938542
77DDR20.50613140
78PRKD30.50407178
79PDK10.50011651
80JAK30.47382932
81MAPK120.46766019
82DAPK30.45609324
83SIK20.45064837
84DYRK1B0.45063927
85ABL20.45003251
86RPS6KA10.44937722
87VRK20.44915377
88SIK30.43877162
89DYRK30.43098215
90KDR0.41860604
91FES0.40777511
92FGR0.40445179
93AURKA0.39861200
94MAP3K60.39725973
95HCK0.37709206
96CSF1R0.36701643
97MAPKAPK20.35740417
98IKBKE0.35448867
99CHUK0.33014123
100EPHB20.32493789

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.89742978
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53657904
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.50238084
4Acute myeloid leukemia_Homo sapiens_hsa052212.36602057
5Bladder cancer_Homo sapiens_hsa052192.07654701
6Chronic myeloid leukemia_Homo sapiens_hsa052202.07230358
7B cell receptor signaling pathway_Homo sapiens_hsa046621.97908894
8Notch signaling pathway_Homo sapiens_hsa043301.92310103
9Osteoclast differentiation_Homo sapiens_hsa043801.91888416
10Sulfur relay system_Homo sapiens_hsa041221.87384756
11Pentose phosphate pathway_Homo sapiens_hsa000301.83481295
12Non-small cell lung cancer_Homo sapiens_hsa052231.76674102
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76135935
14Leishmaniasis_Homo sapiens_hsa051401.66325214
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.66229632
16VEGF signaling pathway_Homo sapiens_hsa043701.65741687
17Fructose and mannose metabolism_Homo sapiens_hsa000511.53597436
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51417964
19Galactose metabolism_Homo sapiens_hsa000521.51043434
20Pancreatic cancer_Homo sapiens_hsa052121.49289593
21Prion diseases_Homo sapiens_hsa050201.47445719
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37670028
23Thyroid cancer_Homo sapiens_hsa052161.36000554
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.26583331
25TNF signaling pathway_Homo sapiens_hsa046681.25685005
26Renal cell carcinoma_Homo sapiens_hsa052111.24419854
27Endometrial cancer_Homo sapiens_hsa052131.24138643
28Lysosome_Homo sapiens_hsa041421.19617149
29Tuberculosis_Homo sapiens_hsa051521.19462315
30Insulin signaling pathway_Homo sapiens_hsa049101.17492309
31Apoptosis_Homo sapiens_hsa042101.16770077
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.16166921
33Hepatitis C_Homo sapiens_hsa051601.14878156
34Influenza A_Homo sapiens_hsa051641.14481753
35Hepatitis B_Homo sapiens_hsa051611.14046027
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.12045995
37Ribosome_Homo sapiens_hsa030101.10471824
38Toxoplasmosis_Homo sapiens_hsa051451.08950549
39Shigellosis_Homo sapiens_hsa051311.06090302
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04606472
41Salmonella infection_Homo sapiens_hsa051321.04288332
42Viral carcinogenesis_Homo sapiens_hsa052031.03480929
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.02813925
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02354091
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.01191225
46Biosynthesis of amino acids_Homo sapiens_hsa012301.00983634
47Malaria_Homo sapiens_hsa051441.00180576
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99834328
49mTOR signaling pathway_Homo sapiens_hsa041500.94361807
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.94064605
51Herpes simplex infection_Homo sapiens_hsa051680.93808685
52HTLV-I infection_Homo sapiens_hsa051660.92460163
53Staphylococcus aureus infection_Homo sapiens_hsa051500.89186530
54Glioma_Homo sapiens_hsa052140.87404897
55ErbB signaling pathway_Homo sapiens_hsa040120.87131141
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86686347
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85484976
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82984269
59Amoebiasis_Homo sapiens_hsa051460.82252625
60Insulin resistance_Homo sapiens_hsa049310.80534519
61HIF-1 signaling pathway_Homo sapiens_hsa040660.80321052
62Prolactin signaling pathway_Homo sapiens_hsa049170.78306872
63Epstein-Barr virus infection_Homo sapiens_hsa051690.77606583
64Colorectal cancer_Homo sapiens_hsa052100.76258826
65Small cell lung cancer_Homo sapiens_hsa052220.75014984
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74041425
67Systemic lupus erythematosus_Homo sapiens_hsa053220.73862123
68T cell receptor signaling pathway_Homo sapiens_hsa046600.73498176
69Prostate cancer_Homo sapiens_hsa052150.73011440
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71804194
71Measles_Homo sapiens_hsa051620.71784697
72Chemokine signaling pathway_Homo sapiens_hsa040620.71463465
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.70636532
74GnRH signaling pathway_Homo sapiens_hsa049120.69220219
75Pertussis_Homo sapiens_hsa051330.68933653
76Proteoglycans in cancer_Homo sapiens_hsa052050.68102570
77AMPK signaling pathway_Homo sapiens_hsa041520.68053438
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65727721
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64911614
80Endocytosis_Homo sapiens_hsa041440.64534246
81Legionellosis_Homo sapiens_hsa051340.64296991
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63270690
83Viral myocarditis_Homo sapiens_hsa054160.62182362
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.61601921
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60271336
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56721916
87MicroRNAs in cancer_Homo sapiens_hsa052060.56137998
88DNA replication_Homo sapiens_hsa030300.55661129
89African trypanosomiasis_Homo sapiens_hsa051430.55352141
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55155292
91Vibrio cholerae infection_Homo sapiens_hsa051100.54343715
92Focal adhesion_Homo sapiens_hsa045100.53086727
93Carbon metabolism_Homo sapiens_hsa012000.52701314
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51731866
95Choline metabolism in cancer_Homo sapiens_hsa052310.51299354
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49610664
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49541089
98Phagosome_Homo sapiens_hsa041450.49033168
99Estrogen signaling pathway_Homo sapiens_hsa049150.46288045
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46008251

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