ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.89646884
2	regulation of posttranscriptional gene silencing (GO:0060147)	4.20043747
3	regulation of gene silencing by miRNA (GO:0060964)	4.20043747
4	regulation of gene silencing by RNA (GO:0060966)	4.20043747
5	L-fucose catabolic process (GO:0042355)	4.10299694
6	fucose catabolic process (GO:0019317)	4.10299694
7	L-fucose metabolic process (GO:0042354)	4.10299694
8	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.89894440
9	tryptophan catabolic process (GO:0006569)	3.82634221
10	indole-containing compound catabolic process (GO:0042436)	3.82634221
11	indolalkylamine catabolic process (GO:0046218)	3.82634221
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.79027781
13	piRNA metabolic process (GO:0034587)	3.77344340
14	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.68680190
15	synapsis (GO:0007129)	3.66776932
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.64799115
17	kynurenine metabolic process (GO:0070189)	3.62908094
18	DNA double-strand break processing (GO:0000729)	3.62297329
19	indolalkylamine metabolic process (GO:0006586)	3.59475804
20	replication fork processing (GO:0031297)	3.52662931
21	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.51627137
22	regulation of translation, ncRNA-mediated (GO:0045974)	3.51627137
23	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.51627137
24	regulation of mitotic spindle checkpoint (GO:1903504)	3.39662132
25	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.39662132
26	regulation of meiosis I (GO:0060631)	3.34944085
27	tryptophan metabolic process (GO:0006568)	3.28292985
28	retinal cone cell development (GO:0046549)	3.27603272
29	reciprocal meiotic recombination (GO:0007131)	3.27438290
30	reciprocal DNA recombination (GO:0035825)	3.27438290
31	centriole replication (GO:0007099)	3.25064505
32	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.21849530
33	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.21849530
34	recombinational repair (GO:0000725)	3.15493161
35	double-strand break repair via homologous recombination (GO:0000724)	3.14787889
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.06079191
37	cellular ketone body metabolic process (GO:0046950)	3.04003716
38	DNA methylation involved in gamete generation (GO:0043046)	3.03554401
39	kidney morphogenesis (GO:0060993)	3.01626435
40	DNA deamination (GO:0045006)	3.00984221
41	neural tube formation (GO:0001841)	2.98292503
42	chromatin remodeling at centromere (GO:0031055)	2.97702635
43	meiotic chromosome segregation (GO:0045132)	2.97451249
44	ketone body metabolic process (GO:1902224)	2.90861403
45	negative regulation of telomere maintenance (GO:0032205)	2.89937443
46	DNA replication-dependent nucleosome organization (GO:0034723)	2.89842940
47	DNA replication-dependent nucleosome assembly (GO:0006335)	2.89842940
48	epithelial cilium movement (GO:0003351)	2.89347435
49	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.89023970
50	regulation of hippo signaling (GO:0035330)	2.87042338
51	response to pheromone (GO:0019236)	2.84027444
52	regulation of centriole replication (GO:0046599)	2.79771153
53	CENP-A containing nucleosome assembly (GO:0034080)	2.77602983
54	nonmotile primary cilium assembly (GO:0035058)	2.76984459
55	cilium or flagellum-dependent cell motility (GO:0001539)	2.76328136
56	indole-containing compound metabolic process (GO:0042430)	2.75268435
57	sulfation (GO:0051923)	2.75236406
58	male meiosis (GO:0007140)	2.74918617
59	somite rostral/caudal axis specification (GO:0032525)	2.73186456
60	protein-cofactor linkage (GO:0018065)	2.73136687
61	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.71634173
62	oxidative demethylation (GO:0070989)	2.70710230
63	DNA replication checkpoint (GO:0000076)	2.69200758
64	multicellular organism reproduction (GO:0032504)	2.67975461
65	histone exchange (GO:0043486)	2.66401735
66	prenylation (GO:0097354)	2.65434549
67	protein prenylation (GO:0018342)	2.65434549
68	detection of light stimulus involved in sensory perception (GO:0050962)	2.63499914
69	detection of light stimulus involved in visual perception (GO:0050908)	2.63499914
70	behavioral response to ethanol (GO:0048149)	2.62959958
71	male meiosis I (GO:0007141)	2.61723037
72	translesion synthesis (GO:0019985)	2.61445950
73	meiotic cell cycle (GO:0051321)	2.61332266
74	respiratory chain complex IV assembly (GO:0008535)	2.61287996
75	protein localization to cilium (GO:0061512)	2.59903133
76	regulation of mesoderm development (GO:2000380)	2.58015429
77	neuronal action potential (GO:0019228)	2.57311546
78	photoreceptor cell maintenance (GO:0045494)	2.55742587
79	cilium movement (GO:0003341)	2.55661419
80	exogenous drug catabolic process (GO:0042738)	2.54358179
81	protein K11-linked deubiquitination (GO:0035871)	2.53005019
82	protein K6-linked ubiquitination (GO:0085020)	2.52475087
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.51755869
84	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.51755869
85	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.51384126
86	protein complex biogenesis (GO:0070271)	2.48188723
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48054366
88	gamma-aminobutyric acid transport (GO:0015812)	2.46983506
89	drug catabolic process (GO:0042737)	2.46211813
90	postreplication repair (GO:0006301)	2.45996854
91	gene silencing by RNA (GO:0031047)	2.45966509
92	cilium morphogenesis (GO:0060271)	2.45468766
93	resolution of meiotic recombination intermediates (GO:0000712)	2.44626336
94	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.43897365
95	NADH dehydrogenase complex assembly (GO:0010257)	2.43897365
96	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.43897365
97	mitochondrial respiratory chain complex assembly (GO:0033108)	2.42296143
98	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.41841663
99	cilium organization (GO:0044782)	2.40647951
100	cytochrome complex assembly (GO:0017004)	2.38728153

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	4.01966039
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.94427352
3	VDR_22108803_ChIP-Seq_LS180_Human	3.20142648
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.02886247
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.73654821
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.73374301
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.47390506
8	EWS_26573619_Chip-Seq_HEK293_Human	2.44751585
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.44672517
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40879679
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39824849
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.34664659
13	FUS_26573619_Chip-Seq_HEK293_Human	2.34290377
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22099289
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19427902
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.16160711
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.15511401
18	P300_19829295_ChIP-Seq_ESCs_Human	2.08973577
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02348660
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.94457222
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.82637756
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.81786869
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.81633665
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76480496
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.71936071
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.70489418
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65745950
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.65094121
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64729176
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.64729176
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61791559
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60098068
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59373252
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57070596
35	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.56734988
36	STAT3_23295773_ChIP-Seq_U87_Human	1.55996553
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.51639046
38	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.50313274
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.47561687
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47561687
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.45865103
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.44883731
43	TCF4_23295773_ChIP-Seq_U87_Human	1.44171988
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.44152114
45	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44132133
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41831012
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.40816547
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39490204
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38300097
50	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.37290799
51	AR_25329375_ChIP-Seq_VCAP_Human	1.36693183
52	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35606148
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34382501
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32742419
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30478191
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29923512
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29923512
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29496212
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28180249
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28180249
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27432727
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26395954
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25741553
64	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25227509
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24400325
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.23370420
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23090773
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20796609
69	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20588447
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19214971
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14300367
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13911915
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13307307
74	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12199247
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12075416
76	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11546469
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09386834
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09129946
79	AR_21572438_ChIP-Seq_LNCaP_Human	1.06221115
80	AR_20517297_ChIP-Seq_VCAP_Human	1.05575773
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04441017
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03684037
83	E2F7_22180533_ChIP-Seq_HELA_Human	1.03438472
84	VDR_23849224_ChIP-Seq_CD4+_Human	1.03259669
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03213154
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03001833
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02897802
88	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01613403
89	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01323832
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01086098
91	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00104689
92	NCOR_22424771_ChIP-Seq_293T_Human	0.98650972
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97831516
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97433246
95	TP53_16413492_ChIP-PET_HCT116_Human	0.96973509
96	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.96383131
97	* HOXB7_26014856_ChIP-Seq_BT474_Human	0.96379452
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.95973243
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94838633
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93315573

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.69741228
2	MP0003136_yellow_coat_color	3.60767703
3	MP0003195_calcinosis	3.08927828
4	MP0003718_maternal_effect	2.66804923
5	MP0006292_abnormal_olfactory_placode	2.57320586
6	MP0003646_muscle_fatigue	2.39011092
7	MP0003890_abnormal_embryonic-extraembry	2.36083336
8	MP0000569_abnormal_digit_pigmentation	2.28742374
9	MP0008057_abnormal_DNA_replication	2.28617268
10	MP0002102_abnormal_ear_morphology	2.22309148
11	MP0004147_increased_porphyrin_level	2.18582673
12	MP0005551_abnormal_eye_electrophysiolog	2.13052906
13	MP0008058_abnormal_DNA_repair	1.96367131
14	MP0002736_abnormal_nociception_after	1.81811359
15	MP0004133_heterotaxia	1.81619042
16	MP0001968_abnormal_touch/_nociception	1.81249522
17	MP0001485_abnormal_pinna_reflex	1.72681924
18	MP0002638_abnormal_pupillary_reflex	1.72582608
19	MP0000372_irregular_coat_pigmentation	1.70662071
20	MP0010094_abnormal_chromosome_stability	1.69935765
21	MP0004043_abnormal_pH_regulation	1.68075520
22	MP0006072_abnormal_retinal_apoptosis	1.66764439
23	MP0009046_muscle_twitch	1.66623436
24	MP0004885_abnormal_endolymph	1.63585315
25	MP0002938_white_spotting	1.63443877
26	MP0008872_abnormal_physiological_respon	1.62932348
27	MP0005645_abnormal_hypothalamus_physiol	1.59593311
28	MP0003787_abnormal_imprinting	1.57708798
29	MP0005253_abnormal_eye_physiology	1.53699270
30	MP0000427_abnormal_hair_cycle	1.53048704
31	MP0004142_abnormal_muscle_tone	1.48720819
32	MP0008875_abnormal_xenobiotic_pharmacok	1.46627602
33	MP0000631_abnormal_neuroendocrine_gland	1.46518608
34	MP0009745_abnormal_behavioral_response	1.45637449
35	MP0005377_hearing/vestibular/ear_phenot	1.44359072
36	MP0003878_abnormal_ear_physiology	1.44359072
37	MP0003693_abnormal_embryo_hatching	1.43738542
38	MP0003283_abnormal_digestive_organ	1.40826135
39	MP0002735_abnormal_chemical_nociception	1.40360946
40	MP0001293_anophthalmia	1.40013566
41	MP0001529_abnormal_vocalization	1.39978517
42	MP0002272_abnormal_nervous_system	1.38255932
43	MP0003119_abnormal_digestive_system	1.36529147
44	MP0001986_abnormal_taste_sensitivity	1.35132517
45	MP0003011_delayed_dark_adaptation	1.26019633
46	MP0001486_abnormal_startle_reflex	1.25078950
47	MP0005174_abnormal_tail_pigmentation	1.24934434
48	MP0006276_abnormal_autonomic_nervous	1.24612011
49	MP0000383_abnormal_hair_follicle	1.24130757
50	MP0005646_abnormal_pituitary_gland	1.23924148
51	MP0002653_abnormal_ependyma_morphology	1.22613143
52	MP0002234_abnormal_pharynx_morphology	1.22377065
53	MP0010386_abnormal_urinary_bladder	1.20644125
54	MP0002160_abnormal_reproductive_system	1.19610611
55	MP0001501_abnormal_sleep_pattern	1.19209056
56	MP0002210_abnormal_sex_determination	1.17858942
57	MP0001929_abnormal_gametogenesis	1.16741597
58	MP0004924_abnormal_behavior	1.15194881
59	MP0005386_behavior/neurological_phenoty	1.15194881
60	MP0005085_abnormal_gallbladder_physiolo	1.14388267
61	MP0001984_abnormal_olfaction	1.14331206
62	MP0003880_abnormal_central_pattern	1.13841857
63	MP0005389_reproductive_system_phenotype	1.13555858
64	MP0003937_abnormal_limbs/digits/tail_de	1.10307227
65	MP0002876_abnormal_thyroid_physiology	1.05984844
66	MP0008789_abnormal_olfactory_epithelium	1.05579667
67	MP0008995_early_reproductive_senescence	1.01535179
68	MP0003121_genomic_imprinting	1.00160072
69	MP0005195_abnormal_posterior_eye	0.98855214
70	MP0003698_abnormal_male_reproductive	0.98579043
71	MP0002572_abnormal_emotion/affect_behav	0.97870462
72	MP0002751_abnormal_autonomic_nervous	0.97273158
73	MP0002557_abnormal_social/conspecific_i	0.97134549
74	MP0000653_abnormal_sex_gland	0.96218630
75	MP0002067_abnormal_sensory_capabilities	0.95825044
76	MP0002837_dystrophic_cardiac_calcinosis	0.95249164
77	MP0005395_other_phenotype	0.93318126
78	MP0004742_abnormal_vestibular_system	0.92223560
79	MP0003567_abnormal_fetal_cardiomyocyte	0.91302930
80	MP0004215_abnormal_myocardial_fiber	0.90996125
81	MP0001324_abnormal_eye_pigmentation	0.89821204
82	MP0005394_taste/olfaction_phenotype	0.89116066
83	MP0005499_abnormal_olfactory_system	0.89116066
84	MP0001919_abnormal_reproductive_system	0.89104726
85	MP0001145_abnormal_male_reproductive	0.88106268
86	MP0002928_abnormal_bile_duct	0.87411445
87	MP0009697_abnormal_copulation	0.86072547
88	MP0005084_abnormal_gallbladder_morpholo	0.85940733
89	MP0002095_abnormal_skin_pigmentation	0.85856874
90	MP0005171_absent_coat_pigmentation	0.85766204
91	MP0005075_abnormal_melanosome_morpholog	0.85163310
92	MP0002163_abnormal_gland_morphology	0.84223727
93	MP0000647_abnormal_sebaceous_gland	0.82978308
94	MP0002064_seizures	0.82750320
95	MP0005410_abnormal_fertilization	0.82293477
96	MP0003252_abnormal_bile_duct	0.81302337
97	MP0001119_abnormal_female_reproductive	0.79449770
98	MP0002138_abnormal_hepatobiliary_system	0.78546786
99	MP0002733_abnormal_thermal_nociception	0.78268780
100	MP0001970_abnormal_pain_threshold	0.76857854

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.10990576
2	Birth length less than 3rd percentile (HP:0003561)	3.90320957
3	Molar tooth sign on MRI (HP:0002419)	3.79991628
4	Abnormality of midbrain morphology (HP:0002418)	3.79991628
5	Pancreatic fibrosis (HP:0100732)	3.65383860
6	Congenital stationary night blindness (HP:0007642)	3.55260718
7	True hermaphroditism (HP:0010459)	3.38795800
8	Nephronophthisis (HP:0000090)	3.29322903
9	Type II lissencephaly (HP:0007260)	3.23704317
10	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.18708685
11	Abnormality of alanine metabolism (HP:0010916)	3.18708685
12	Hyperalaninemia (HP:0003348)	3.18708685
13	Attenuation of retinal blood vessels (HP:0007843)	2.95666360
14	Abnormality of the renal medulla (HP:0100957)	2.83285165
15	Abnormality of the renal cortex (HP:0011035)	2.74751918
16	Chronic hepatic failure (HP:0100626)	2.74418889
17	Hyperventilation (HP:0002883)	2.73286900
18	Cerebellar dysplasia (HP:0007033)	2.64897000
19	Abnormality of the labia minora (HP:0012880)	2.64500850
20	Abolished electroretinogram (ERG) (HP:0000550)	2.63931794
21	Inability to walk (HP:0002540)	2.63125200
22	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.61879126
23	Medial flaring of the eyebrow (HP:0010747)	2.58986223
24	Patellar aplasia (HP:0006443)	2.49319430
25	Progressive inability to walk (HP:0002505)	2.49066995
26	Abnormality of the pons (HP:0007361)	2.43779221
27	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.41902470
28	Cystic liver disease (HP:0006706)	2.40965730
29	Supernumerary spleens (HP:0009799)	2.40759545
30	Abnormal biliary tract physiology (HP:0012439)	2.39939352
31	Bile duct proliferation (HP:0001408)	2.39939352
32	Meckel diverticulum (HP:0002245)	2.38121031
33	Colon cancer (HP:0003003)	2.37601510
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.37233107
35	Abnormality of the ileum (HP:0001549)	2.37104596
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.36488995
37	Absent/shortened dynein arms (HP:0200106)	2.36488995
38	Tubular atrophy (HP:0000092)	2.35799195
39	Hypoplasia of the pons (HP:0012110)	2.34570041
40	Gaze-evoked nystagmus (HP:0000640)	2.33544847
41	Pendular nystagmus (HP:0012043)	2.31660242
42	Aplasia/Hypoplasia of the patella (HP:0006498)	2.31475095
43	Protruding tongue (HP:0010808)	2.25923393
44	Lissencephaly (HP:0001339)	2.24090955
45	Decreased central vision (HP:0007663)	2.18667341
46	Chromsome breakage (HP:0040012)	2.18039329
47	Sclerocornea (HP:0000647)	2.14776124
48	Congenital, generalized hypertrichosis (HP:0004540)	2.14658079
49	Abnormal ciliary motility (HP:0012262)	2.09742389
50	Abnormality of chromosome stability (HP:0003220)	2.09214878
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09166581
52	Genetic anticipation (HP:0003743)	2.06973144
53	Anencephaly (HP:0002323)	2.05898402
54	Gait imbalance (HP:0002141)	2.05822369
55	Congenital primary aphakia (HP:0007707)	2.05815361
56	Retinal dysplasia (HP:0007973)	2.05079234
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01944323
58	Abnormal respiratory epithelium morphology (HP:0012253)	2.01944323
59	Methylmalonic acidemia (HP:0002912)	2.00340885
60	Abnormality of the renal collecting system (HP:0004742)	2.00307597
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00194658
62	Abnormal drinking behavior (HP:0030082)	2.00159796
63	Polydipsia (HP:0001959)	2.00159796
64	Duplicated collecting system (HP:0000081)	1.99304177
65	Hypoplasia of the fovea (HP:0007750)	1.97277958
66	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.97277958
67	Optic nerve hypoplasia (HP:0000609)	1.96482940
68	Fair hair (HP:0002286)	1.94371069
69	Concave nail (HP:0001598)	1.94047595
70	Septo-optic dysplasia (HP:0100842)	1.94017553
71	Ectopic kidney (HP:0000086)	1.93504122
72	Nephrogenic diabetes insipidus (HP:0009806)	1.91711526
73	Bony spicule pigmentary retinopathy (HP:0007737)	1.89878999
74	Abnormality of the fovea (HP:0000493)	1.89695126
75	Dandy-Walker malformation (HP:0001305)	1.89479602
76	Clumsiness (HP:0002312)	1.89285963
77	Congenital hepatic fibrosis (HP:0002612)	1.88063111
78	Clubbing of toes (HP:0100760)	1.87557159
79	Renal cortical cysts (HP:0000803)	1.86877049
80	Stomach cancer (HP:0012126)	1.86839320
81	Genital tract atresia (HP:0001827)	1.86512578
82	Sloping forehead (HP:0000340)	1.86014718
83	Progressive cerebellar ataxia (HP:0002073)	1.85175713
84	Large for gestational age (HP:0001520)	1.85043999
85	Broad-based gait (HP:0002136)	1.83358058
86	Abnormal respiratory motile cilium physiology (HP:0012261)	1.81487411
87	Chorioretinal atrophy (HP:0000533)	1.80284239
88	Congenital sensorineural hearing impairment (HP:0008527)	1.80146204
89	Breast hypoplasia (HP:0003187)	1.78776631
90	Small intestinal stenosis (HP:0012848)	1.77803545
91	Duodenal stenosis (HP:0100867)	1.77803545
92	Intestinal atresia (HP:0011100)	1.76164092
93	Triphalangeal thumb (HP:0001199)	1.74932978
94	Furrowed tongue (HP:0000221)	1.74344345
95	Male pseudohermaphroditism (HP:0000037)	1.74006152
96	Small hand (HP:0200055)	1.73330545
97	Vaginal atresia (HP:0000148)	1.72806504
98	Abnormality of serum amino acid levels (HP:0003112)	1.71903505
99	Abnormality of the preputium (HP:0100587)	1.71716533
100	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.71491378

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.80400030
2	ZAK	3.57745549
3	ACVR1B	3.22940023
4	BMPR1B	3.19367743
5	ADRBK2	2.69268605
6	INSRR	2.46336814
7	MAP4K2	2.34372116
8	WNK4	2.28484579
9	NUAK1	2.25733229
10	WNK3	2.25368124
11	MKNK2	2.04577288
12	TNIK	2.02752392
13	PINK1	1.99196541
14	GRK1	1.91585785
15	PNCK	1.85275813
16	TAOK3	1.79583911
17	WEE1	1.75976713
18	MAPK13	1.69724479
19	TGFBR1	1.65109060
20	MKNK1	1.58045681
21	TLK1	1.53777742
22	BRSK2	1.47485039
23	CDC7	1.43497032
24	CASK	1.43388913
25	DAPK2	1.43345905
26	TSSK6	1.40718534
27	PLK3	1.36842849
28	OXSR1	1.33904683
29	STK39	1.31224684
30	VRK1	1.25738106
31	BUB1	1.24837557
32	PLK4	1.20633163
33	TTK	1.20386004
34	ADRBK1	1.14999881
35	MAP3K4	1.06963354
36	TRIM28	1.02565702
37	PLK1	0.97756684
38	DYRK2	0.94053779
39	CDK19	0.93509592
40	CHEK2	0.90587969
41	NEK2	0.88679810
42	TIE1	0.88644854
43	PASK	0.85334742
44	STK38L	0.84797047
45	SRPK1	0.77976376
46	PRKCG	0.77500128
47	NTRK3	0.72902020
48	ATR	0.70565826
49	MAPKAPK5	0.69351125
50	STK3	0.69159706
51	PRKCE	0.66943039
52	AKT3	0.66206863
53	CSNK1G2	0.64923188
54	PKN1	0.63088711
55	RPS6KA5	0.62691319
56	TAF1	0.62658305
57	PIK3CA	0.62314115
58	MAPK15	0.61406542
59	PAK3	0.58974766
60	NME1	0.58750849
61	TEC	0.58058991
62	CSNK1G1	0.56712024
63	CDK3	0.56023116
64	ATM	0.54920775
65	NLK	0.54444371
66	TXK	0.54268149
67	PBK	0.54140974
68	NTRK2	0.54019028
69	MARK3	0.52798481
70	EIF2AK3	0.52691806
71	STK11	0.51703177
72	BCKDK	0.50574695
73	CAMKK2	0.50425550
74	PLK2	0.49974085
75	CAMK2A	0.49125323
76	PIM1	0.48950481
77	WNK1	0.48670396
78	PIK3CG	0.46295023
79	DYRK3	0.44261944
80	PRKCQ	0.43922282
81	MAPKAPK3	0.43647135
82	CSNK1G3	0.43561522
83	OBSCN	0.41657225
84	CCNB1	0.41644739
85	EPHA4	0.40860968
86	CAMK1	0.39966097
87	CSNK1D	0.39498565
88	MUSK	0.39235769
89	PRKACA	0.38224556
90	KIT	0.37988367
91	MAP2K7	0.36327740
92	PRKG1	0.35935992
93	PTK2B	0.35417128
94	MELK	0.35060704
95	MST4	0.31978018
96	PRKACB	0.31396038
97	FLT3	0.30720549
98	NEK1	0.30614047
99	AURKB	0.29643838
100	CSNK1A1	0.27156790

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	2.83897037
2	Caffeine metabolism_Homo sapiens_hsa00232	2.77553770
3	Phototransduction_Homo sapiens_hsa04744	2.55130593
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.53893797
5	Butanoate metabolism_Homo sapiens_hsa00650	2.44906166
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.41860267
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.41020326
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39030906
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.38224544
10	Basal transcription factors_Homo sapiens_hsa03022	2.28916319
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.13935509
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.08266226
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.99386546
14	Nicotine addiction_Homo sapiens_hsa05033	1.94966860
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90845959
16	RNA polymerase_Homo sapiens_hsa03020	1.89300604
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.87472514
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.85490028
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81246340
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80323797
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.76801369
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.62815425
23	Propanoate metabolism_Homo sapiens_hsa00640	1.60855258
24	One carbon pool by folate_Homo sapiens_hsa00670	1.59266113
25	Taste transduction_Homo sapiens_hsa04742	1.52762935
26	Mismatch repair_Homo sapiens_hsa03430	1.47979690
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.45893126
28	RNA degradation_Homo sapiens_hsa03018	1.43827916
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.41164252
30	Olfactory transduction_Homo sapiens_hsa04740	1.35507338
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33719700
32	ABC transporters_Homo sapiens_hsa02010	1.33465440
33	Protein export_Homo sapiens_hsa03060	1.33183185
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.30691427
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29572114
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27270233
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23473563
38	Retinol metabolism_Homo sapiens_hsa00830	1.13111819
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11461808
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10926874
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10634257
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06952192
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.06287250
44	Morphine addiction_Homo sapiens_hsa05032	1.03429152
45	Parkinsons disease_Homo sapiens_hsa05012	1.03000790
46	Cell cycle_Homo sapiens_hsa04110	0.98147515
47	Peroxisome_Homo sapiens_hsa04146	0.95274287
48	RNA transport_Homo sapiens_hsa03013	0.95109415
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92783552
50	Ribosome_Homo sapiens_hsa03010	0.91574988
51	Serotonergic synapse_Homo sapiens_hsa04726	0.90401791
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88921832
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85550013
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85219993
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84554908
56	DNA replication_Homo sapiens_hsa03030	0.83949998
57	Purine metabolism_Homo sapiens_hsa00230	0.83898081
58	Huntingtons disease_Homo sapiens_hsa05016	0.82806033
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82589765
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78776510
61	Sulfur relay system_Homo sapiens_hsa04122	0.76315533
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75257595
63	GABAergic synapse_Homo sapiens_hsa04727	0.73384739
64	Histidine metabolism_Homo sapiens_hsa00340	0.72445690
65	Base excision repair_Homo sapiens_hsa03410	0.71368214
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70568598
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67971757
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67532915
69	Regulation of autophagy_Homo sapiens_hsa04140	0.66529841
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63729488
71	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61252810
72	p53 signaling pathway_Homo sapiens_hsa04115	0.57940226
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56918780
74	Metabolic pathways_Homo sapiens_hsa01100	0.56344063
75	Circadian entrainment_Homo sapiens_hsa04713	0.56322408
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.55290026
77	Insulin secretion_Homo sapiens_hsa04911	0.55268931
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.54103415
79	Lysine degradation_Homo sapiens_hsa00310	0.53276614
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.52784503
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.52267761
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.50838606
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50390379
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.49785804
85	Alzheimers disease_Homo sapiens_hsa05010	0.47074286
86	Fatty acid degradation_Homo sapiens_hsa00071	0.46876407
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45887628
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.45520256
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.40525012
90	Asthma_Homo sapiens_hsa05310	0.38697511
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35778960
92	Proteasome_Homo sapiens_hsa03050	0.35227390
93	Long-term depression_Homo sapiens_hsa04730	0.35075349
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35017175
95	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33772747
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.33691428
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33072117
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.31878456
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.31133278
100	Salivary secretion_Homo sapiens_hsa04970	0.30940622

ZNF788

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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