ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.87396227
2	fucose catabolic process (GO:0019317)	4.74184051
3	L-fucose metabolic process (GO:0042354)	4.74184051
4	L-fucose catabolic process (GO:0042355)	4.74184051
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.98539169
6	rRNA catabolic process (GO:0016075)	3.56705900
7	reciprocal DNA recombination (GO:0035825)	3.39948275
8	reciprocal meiotic recombination (GO:0007131)	3.39948275
9	DNA deamination (GO:0045006)	3.38357561
10	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.36783875
11	replication fork processing (GO:0031297)	3.32526650
12	positive regulation of prostaglandin secretion (GO:0032308)	3.30650211
13	response to pheromone (GO:0019236)	3.28558219
14	epithelial cilium movement (GO:0003351)	3.28151284
15	indolalkylamine metabolic process (GO:0006586)	3.23811619
16	histone H3-K4 trimethylation (GO:0080182)	3.23746668
17	protein K11-linked deubiquitination (GO:0035871)	3.20457951
18	neural tube formation (GO:0001841)	3.16904357
19	axoneme assembly (GO:0035082)	3.13667661
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.11106497
21	kynurenine metabolic process (GO:0070189)	3.09380135
22	preassembly of GPI anchor in ER membrane (GO:0016254)	3.07790426
23	double-strand break repair via homologous recombination (GO:0000724)	3.07108934
24	recombinational repair (GO:0000725)	3.05172685
25	tryptophan catabolic process (GO:0006569)	3.04570094
26	indole-containing compound catabolic process (GO:0042436)	3.04570094
27	indolalkylamine catabolic process (GO:0046218)	3.04570094
28	establishment of protein localization to Golgi (GO:0072600)	3.01701451
29	detection of light stimulus involved in visual perception (GO:0050908)	3.00499125
30	detection of light stimulus involved in sensory perception (GO:0050962)	3.00499125
31	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.98189100
32	positive regulation of developmental pigmentation (GO:0048087)	2.96163555
33	respiratory chain complex IV assembly (GO:0008535)	2.96066860
34	nonmotile primary cilium assembly (GO:0035058)	2.94523766
35	positive regulation of fatty acid transport (GO:2000193)	2.94306743
36	DNA double-strand break processing (GO:0000729)	2.91998016
37	cilium morphogenesis (GO:0060271)	2.89532826
38	monoubiquitinated protein deubiquitination (GO:0035520)	2.89456845
39	protein localization to cilium (GO:0061512)	2.87243331
40	protein complex biogenesis (GO:0070271)	2.86393517
41	fucosylation (GO:0036065)	2.80809377
42	cilium or flagellum-dependent cell motility (GO:0001539)	2.80483022
43	cytochrome complex assembly (GO:0017004)	2.79715624
44	tryptophan metabolic process (GO:0006568)	2.79642718
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79522244
46	NADH dehydrogenase complex assembly (GO:0010257)	2.79522244
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79522244
48	histone H3-K9 methylation (GO:0051567)	2.76925189
49	meiotic chromosome segregation (GO:0045132)	2.75850815
50	regulation of action potential (GO:0098900)	2.75745334
51	protein polyglutamylation (GO:0018095)	2.73972168
52	centriole replication (GO:0007099)	2.73556608
53	mannosylation (GO:0097502)	2.72683591
54	regulation of cilium movement (GO:0003352)	2.72627359
55	positive regulation of icosanoid secretion (GO:0032305)	2.70390782
56	cellular ketone body metabolic process (GO:0046950)	2.70235014
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68951137
58	S-adenosylmethionine metabolic process (GO:0046500)	2.68945546
59	negative regulation of mast cell activation (GO:0033004)	2.67232698
60	photoreceptor cell maintenance (GO:0045494)	2.67225212
61	photoreceptor cell development (GO:0042461)	2.67181575
62	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66614428
63	protein prenylation (GO:0018342)	2.66015914
64	prenylation (GO:0097354)	2.66015914
65	protein-cofactor linkage (GO:0018065)	2.63014550
66	adaptation of signaling pathway (GO:0023058)	2.62487061
67	protein localization to Golgi apparatus (GO:0034067)	2.62429685
68	neuronal action potential (GO:0019228)	2.61710392
69	cilium movement (GO:0003341)	2.61614838
70	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.60901963
71	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.60901963
72	regulation of translation, ncRNA-mediated (GO:0045974)	2.60901963
73	anterograde synaptic vesicle transport (GO:0048490)	2.60305265
74	regulation of prostaglandin secretion (GO:0032306)	2.59707376
75	regulation of telomere maintenance (GO:0032204)	2.59036253
76	cilium organization (GO:0044782)	2.56172830
77	kidney morphogenesis (GO:0060993)	2.55613513
78	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.53771267
79	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.53535056
80	reflex (GO:0060004)	2.53256673
81	cilium assembly (GO:0042384)	2.50834735
82	piRNA metabolic process (GO:0034587)	2.50513086
83	microtubule anchoring (GO:0034453)	2.47831703
84	regulation of hexokinase activity (GO:1903299)	2.46941127
85	regulation of glucokinase activity (GO:0033131)	2.46941127
86	protein targeting to Golgi (GO:0000042)	2.46332318
87	ketone body metabolic process (GO:1902224)	2.46018322
88	interkinetic nuclear migration (GO:0022027)	2.45983805
89	peptidyl-lysine trimethylation (GO:0018023)	2.44363617
90	snRNA transcription (GO:0009301)	2.43211835
91	synapsis (GO:0007129)	2.41706923
92	pyrimidine nucleobase catabolic process (GO:0006208)	2.40064378
93	peptidyl-lysine methylation (GO:0018022)	2.39694579
94	base-excision repair, AP site formation (GO:0006285)	2.39667362
95	positive regulation of histone H3-K4 methylation (GO:0051571)	2.39533412
96	eye photoreceptor cell development (GO:0042462)	2.38374123
97	pseudouridine synthesis (GO:0001522)	2.38265900
98	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.38001713
99	regulation of mitotic spindle checkpoint (GO:1903504)	2.38001713
100	DNA demethylation (GO:0080111)	2.37817861

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.51496840
2	VDR_22108803_ChIP-Seq_LS180_Human	3.42377790
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.10894372
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.65512024
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.53703575
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42294963
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.39582957
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.33778285
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31686932
10	EWS_26573619_Chip-Seq_HEK293_Human	2.28010796
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.23119926
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22780476
13	FUS_26573619_Chip-Seq_HEK293_Human	2.12433266
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.07766316
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06652682
16	* ER_23166858_ChIP-Seq_MCF-7_Human	1.97778183
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.95487906
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.91592471
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.91502175
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90565709
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.88237558
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85148789
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84485322
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.79051880
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75186059
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74301248
27	* VDR_23849224_ChIP-Seq_CD4+_Human	1.68609090
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.67240437
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65200212
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.64961810
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64663568
32	P300_19829295_ChIP-Seq_ESCs_Human	1.58600727
33	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.55179393
34	STAT3_23295773_ChIP-Seq_U87_Human	1.51228221
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.49453602
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46989222
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46422899
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46422899
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44587330
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43598433
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.39342994
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39342994
43	TCF4_23295773_ChIP-Seq_U87_Human	1.39137028
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.38772927
45	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.37088951
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36619807
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33260592
48	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.32799103
49	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.27981295
50	AR_25329375_ChIP-Seq_VCAP_Human	1.27145706
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.26049317
52	CIITA_25753668_ChIP-Seq_RAJI_Human	1.23431218
53	AR_21572438_ChIP-Seq_LNCaP_Human	1.22320546
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.21755267
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20772832
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19800564
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16852603
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16393225
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16207265
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15759388
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15457931
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15457931
63	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13857317
64	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.12542367
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12366438
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.12031852
67	* NCOR_22424771_ChIP-Seq_293T_Human	1.11847792
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11491766
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10784551
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10463929
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10089216
72	AR_20517297_ChIP-Seq_VCAP_Human	1.09095223
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08923886
74	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08308848
75	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.08108328
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07758498
77	ERA_21632823_ChIP-Seq_H3396_Human	1.07723148
78	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05526915
79	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.05012890
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.04942724
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04939740
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04641923
83	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04179752
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03310019
85	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.03272613
86	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.03272613
87	GATA3_26560356_Chip-Seq_TH2_Human	1.03247527
88	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03148605
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02560008
90	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02381069
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01238781
92	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00302605
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99981055
94	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.99771370
95	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.99212545
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98032042
97	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97356149
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96440372
99	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95936771
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94695998

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.47062609
2	MP0006292_abnormal_olfactory_placode	2.95237543
3	MP0002102_abnormal_ear_morphology	2.59862196
4	MP0008877_abnormal_DNA_methylation	2.59405306
5	MP0003787_abnormal_imprinting	2.47845505
6	MP0001986_abnormal_taste_sensitivity	2.42488709
7	MP0000372_irregular_coat_pigmentation	2.21623038
8	MP0002638_abnormal_pupillary_reflex	2.18439500
9	MP0005551_abnormal_eye_electrophysiolog	2.14895119
10	MP0003136_yellow_coat_color	2.14803444
11	MP0001968_abnormal_touch/_nociception	2.09517136
12	MP0003195_calcinosis	2.06964615
13	MP0004043_abnormal_pH_regulation	2.03519165
14	MP0008057_abnormal_DNA_replication	1.97541314
15	MP0005174_abnormal_tail_pigmentation	1.87725378
16	MP0000427_abnormal_hair_cycle	1.80704675
17	MP0008058_abnormal_DNA_repair	1.80370493
18	MP0004142_abnormal_muscle_tone	1.63422785
19	MP0005075_abnormal_melanosome_morpholog	1.59010399
20	MP0004147_increased_porphyrin_level	1.57912048
21	MP0008872_abnormal_physiological_respon	1.57683318
22	MP0009046_muscle_twitch	1.57550731
23	MP0005253_abnormal_eye_physiology	1.56721514
24	MP0003646_muscle_fatigue	1.54944466
25	MP0002938_white_spotting	1.51757215
26	MP0006072_abnormal_retinal_apoptosis	1.51547671
27	MP0005645_abnormal_hypothalamus_physiol	1.45899143
28	MP0008961_abnormal_basal_metabolism	1.42402571
29	MP0008875_abnormal_xenobiotic_pharmacok	1.40163127
30	MP0002095_abnormal_skin_pigmentation	1.38648944
31	MP0002837_dystrophic_cardiac_calcinosis	1.37649819
32	MP0010094_abnormal_chromosome_stability	1.35674874
33	MP0002163_abnormal_gland_morphology	1.34888987
34	MP0004133_heterotaxia	1.33095854
35	MP0008995_early_reproductive_senescence	1.30966910
36	MP0003252_abnormal_bile_duct	1.30738370
37	MP0000631_abnormal_neuroendocrine_gland	1.26735318
38	MP0004924_abnormal_behavior	1.24841901
39	MP0005386_behavior/neurological_phenoty	1.24841901
40	MP0000015_abnormal_ear_pigmentation	1.24703115
41	MP0000383_abnormal_hair_follicle	1.22077147
42	MP0005379_endocrine/exocrine_gland_phen	1.20936922
43	MP0002735_abnormal_chemical_nociception	1.19320680
44	MP0002876_abnormal_thyroid_physiology	1.18591623
45	MP0008789_abnormal_olfactory_epithelium	1.17798303
46	MP0003121_genomic_imprinting	1.15154587
47	MP0005646_abnormal_pituitary_gland	1.15080261
48	MP0009745_abnormal_behavioral_response	1.14245064
49	MP0005171_absent_coat_pigmentation	1.12987978
50	MP0001502_abnormal_circadian_rhythm	1.11877293
51	MP0002928_abnormal_bile_duct	1.08660576
52	MP0001486_abnormal_startle_reflex	1.07788029
53	MP0003718_maternal_effect	1.06754674
54	MP0006276_abnormal_autonomic_nervous	1.06601115
55	MP0005084_abnormal_gallbladder_morpholo	1.06285424
56	MP0002736_abnormal_nociception_after	1.02762018
57	MP0004885_abnormal_endolymph	1.01686905
58	MP0004742_abnormal_vestibular_system	1.00616966
59	MP0005394_taste/olfaction_phenotype	1.00569563
60	MP0005499_abnormal_olfactory_system	1.00569563
61	MP0000371_diluted_coat_color	0.98526905
62	MP0003698_abnormal_male_reproductive	0.97919023
63	MP0005389_reproductive_system_phenotype	0.97773805
64	MP0010386_abnormal_urinary_bladder	0.97152489
65	MP0005187_abnormal_penis_morphology	0.96403033
66	MP0002557_abnormal_social/conspecific_i	0.96193132
67	MP0002751_abnormal_autonomic_nervous	0.95505245
68	MP0002733_abnormal_thermal_nociception	0.93319244
69	MP0002009_preneoplasia	0.93189130
70	MP0000647_abnormal_sebaceous_gland	0.93179900
71	MP0002160_abnormal_reproductive_system	0.91988249
72	MP0001929_abnormal_gametogenesis	0.91726297
73	MP0002272_abnormal_nervous_system	0.90820477
74	MP0001485_abnormal_pinna_reflex	0.89423812
75	MP0002067_abnormal_sensory_capabilities	0.88401052
76	MP0004381_abnormal_hair_follicle	0.88062829
77	MP0003890_abnormal_embryonic-extraembry	0.87447261
78	MP0005423_abnormal_somatic_nervous	0.87373998
79	MP0001970_abnormal_pain_threshold	0.86930091
80	MP0001984_abnormal_olfaction	0.86387532
81	MP0001324_abnormal_eye_pigmentation	0.86264591
82	MP0002909_abnormal_adrenal_gland	0.85492045
83	MP0005195_abnormal_posterior_eye	0.83157371
84	MP0001764_abnormal_homeostasis	0.82725194
85	MP0001529_abnormal_vocalization	0.82665585
86	MP0002210_abnormal_sex_determination	0.79562974
87	MP0005220_abnormal_exocrine_pancreas	0.79558876
88	MP0002572_abnormal_emotion/affect_behav	0.79375250
89	MP0001919_abnormal_reproductive_system	0.77720397
90	MP0001501_abnormal_sleep_pattern	0.77018004
91	MP0002234_abnormal_pharynx_morphology	0.76183121
92	MP0009697_abnormal_copulation	0.74849260
93	MP0002075_abnormal_coat/hair_pigmentati	0.74504287
94	MP0001873_stomach_inflammation	0.74501792
95	MP0010329_abnormal_lipoprotein_level	0.73245595
96	MP0005391_vision/eye_phenotype	0.72751223
97	MP0000538_abnormal_urinary_bladder	0.72399626
98	MP0005410_abnormal_fertilization	0.71612614
99	MP0000653_abnormal_sex_gland	0.71545781
100	MP0005310_abnormal_salivary_gland	0.70454330

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.24263288
2	Pancreatic fibrosis (HP:0100732)	3.76344051
3	Abnormality of midbrain morphology (HP:0002418)	3.69191700
4	Molar tooth sign on MRI (HP:0002419)	3.69191700
5	Congenital stationary night blindness (HP:0007642)	3.63591149
6	Nephronophthisis (HP:0000090)	3.55175846
7	Hyperventilation (HP:0002883)	3.54439492
8	True hermaphroditism (HP:0010459)	3.34418113
9	Birth length less than 3rd percentile (HP:0003561)	3.21319039
10	Attenuation of retinal blood vessels (HP:0007843)	3.14939256
11	Protruding tongue (HP:0010808)	3.14298816
12	Abnormality of the renal medulla (HP:0100957)	3.12841616
13	Abnormality of the renal cortex (HP:0011035)	3.06822633
14	Chronic hepatic failure (HP:0100626)	3.04814804
15	Medial flaring of the eyebrow (HP:0010747)	3.01156805
16	Genetic anticipation (HP:0003743)	2.85706977
17	Cystic liver disease (HP:0006706)	2.68267338
18	Abnormal biliary tract physiology (HP:0012439)	2.68074551
19	Bile duct proliferation (HP:0001408)	2.68074551
20	Gait imbalance (HP:0002141)	2.61707211
21	Congenital primary aphakia (HP:0007707)	2.53823911
22	Tubular atrophy (HP:0000092)	2.51919262
23	Gaze-evoked nystagmus (HP:0000640)	2.47552282
24	Patellar aplasia (HP:0006443)	2.46267061
25	Type II lissencephaly (HP:0007260)	2.45618464
26	Nephrogenic diabetes insipidus (HP:0009806)	2.37883700
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.35859562
28	Progressive cerebellar ataxia (HP:0002073)	2.35125900
29	Abnormal drinking behavior (HP:0030082)	2.34401204
30	Polydipsia (HP:0001959)	2.34401204
31	Absent speech (HP:0001344)	2.31103449
32	Broad-based gait (HP:0002136)	2.31021237
33	Aplasia/Hypoplasia of the patella (HP:0006498)	2.29679359
34	Renal cortical cysts (HP:0000803)	2.25528346
35	Lissencephaly (HP:0001339)	2.24084858
36	Pendular nystagmus (HP:0012043)	2.23045474
37	Intestinal atresia (HP:0011100)	2.19565582
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.19454705
39	Concave nail (HP:0001598)	2.16798789
40	Abolished electroretinogram (ERG) (HP:0000550)	2.16038113
41	Rib fusion (HP:0000902)	2.14618287
42	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.14456738
43	Inability to walk (HP:0002540)	2.07008993
44	Poor coordination (HP:0002370)	2.05691402
45	Hypothermia (HP:0002045)	2.05002401
46	Febrile seizures (HP:0002373)	2.03978655
47	Large for gestational age (HP:0001520)	2.03356711
48	Postaxial foot polydactyly (HP:0001830)	2.01700736
49	Progressive inability to walk (HP:0002505)	1.98925491
50	Cerebellar dysplasia (HP:0007033)	1.98121072
51	Chromsome breakage (HP:0040012)	1.96125522
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96095933
53	Progressive microcephaly (HP:0000253)	1.94699752
54	Stomach cancer (HP:0012126)	1.93661337
55	Fair hair (HP:0002286)	1.93356803
56	Asplenia (HP:0001746)	1.93348025
57	Clumsiness (HP:0002312)	1.93137394
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92546555
59	Genital tract atresia (HP:0001827)	1.92019717
60	Widely spaced teeth (HP:0000687)	1.91571996
61	Severe combined immunodeficiency (HP:0004430)	1.90193856
62	Abnormality of DNA repair (HP:0003254)	1.89917439
63	Congenital hepatic fibrosis (HP:0002612)	1.88884480
64	Duplicated collecting system (HP:0000081)	1.88360042
65	Anencephaly (HP:0002323)	1.87852289
66	Vaginal atresia (HP:0000148)	1.85352579
67	Panhypogammaglobulinemia (HP:0003139)	1.83893843
68	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.83367660
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83245075
70	Thyroiditis (HP:0100646)	1.83134087
71	Tented upper lip vermilion (HP:0010804)	1.82784339
72	Sclerocornea (HP:0000647)	1.80930015
73	Astigmatism (HP:0000483)	1.79980559
74	Decreased central vision (HP:0007663)	1.79231980
75	Polyuria (HP:0000103)	1.78404068
76	Decreased circulating renin level (HP:0003351)	1.77600703
77	Abnormality of the labia minora (HP:0012880)	1.77250530
78	Abnormality of the renal collecting system (HP:0004742)	1.77106871
79	Volvulus (HP:0002580)	1.76580002
80	Abnormality of the ileum (HP:0001549)	1.76561234
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76130227
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.76130227
83	Male pseudohermaphroditism (HP:0000037)	1.75794986
84	Clubbing of toes (HP:0100760)	1.75677334
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.75539972
86	Abnormality of alanine metabolism (HP:0010916)	1.75539972
87	Hyperalaninemia (HP:0003348)	1.75539972
88	Dyskinesia (HP:0100660)	1.75213780
89	Furrowed tongue (HP:0000221)	1.74619018
90	Small hand (HP:0200055)	1.74190422
91	Meckel diverticulum (HP:0002245)	1.73436225
92	Hypoplasia of the pons (HP:0012110)	1.71588638
93	Sloping forehead (HP:0000340)	1.71265122
94	Abnormality of the pons (HP:0007361)	1.71189613
95	Occipital encephalocele (HP:0002085)	1.70163417
96	Postaxial hand polydactyly (HP:0001162)	1.69109696
97	Abnormality of B cell number (HP:0010975)	1.68707129
98	3-Methylglutaconic aciduria (HP:0003535)	1.67861503
99	Prominent nasal bridge (HP:0000426)	1.67430823
100	Hyperglycinuria (HP:0003108)	1.67006908

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.51770477
2	ACVR1B	3.14633584
3	MAP4K2	3.03882425
4	BMPR1B	2.69782605
5	ZAK	2.53720336
6	WNK4	2.53301383
7	NUAK1	2.52181098
8	TLK1	2.43117990
9	ADRBK2	2.29814158
10	CASK	2.26413205
11	AKT3	2.21597595
12	WNK3	2.20451854
13	BRSK2	1.95349925
14	TAOK3	1.94867424
15	MKNK2	1.85627004
16	MAPK13	1.83948322
17	TXK	1.72510307
18	GRK1	1.68974177
19	INSRR	1.55572757
20	MAP3K4	1.53095049
21	OXSR1	1.39009307
22	STK39	1.37707953
23	SIK2	1.23655857
24	NTRK3	1.22836918
25	TEC	1.22443932
26	PINK1	1.16249083
27	PLK4	1.11629605
28	MKNK1	1.10925494
29	PAK3	1.06650079
30	CAMKK2	1.05585047
31	EIF2AK3	1.05292134
32	FGFR2	1.04700403
33	DAPK2	1.04295998
34	MARK1	0.99741341
35	ITK	0.99596368
36	PIK3CA	0.97646787
37	NME1	0.91802152
38	NEK2	0.89463350
39	ATR	0.88700558
40	CCNB1	0.86251237
41	DYRK2	0.80874013
42	MAP2K6	0.78499291
43	SYK	0.76520312
44	ADRBK1	0.76386386
45	WNK1	0.76138567
46	BTK	0.73539659
47	CDK12	0.72178049
48	MAP3K7	0.72122164
49	CSNK1A1L	0.71196332
50	ERBB2	0.69350297
51	TGFBR1	0.68281769
52	TNK2	0.67411882
53	BRD4	0.63543500
54	PRKAA2	0.62949332
55	TRIM28	0.62714804
56	WEE1	0.62442491
57	IKBKB	0.61932873
58	PRKCE	0.61567072
59	CSNK1G2	0.60724634
60	ERBB3	0.60091552
61	RPS6KA5	0.59246959
62	NTRK2	0.58848130
63	PRKAA1	0.56401147
64	CSNK1G1	0.56025949
65	CAMK1D	0.55491801
66	TNIK	0.55478740
67	CDK3	0.55298413
68	CHEK2	0.54914225
69	MAP4K1	0.53259602
70	MAPKAPK5	0.53014995
71	ATM	0.52419195
72	PRKCG	0.52335889
73	MAPK11	0.52223699
74	CHUK	0.52168017
75	BCR	0.52093467
76	PRKCQ	0.50526592
77	STK3	0.50151986
78	CSNK1G3	0.49835722
79	MAPK15	0.47917912
80	KIT	0.45735834
81	SGK2	0.45656433
82	FLT3	0.44372055
83	CSNK1D	0.43622715
84	VRK1	0.41793146
85	CAMK1G	0.41790454
86	CDK8	0.40927070
87	DYRK1A	0.40887779
88	LYN	0.40104063
89	CSNK1A1	0.38287383
90	PHKG1	0.37862299
91	PHKG2	0.37862299
92	CAMK1	0.36906333
93	PTK2B	0.36757646
94	PLK1	0.36708364
95	SGK1	0.36139626
96	STK11	0.35260697
97	PRKACA	0.34622356
98	PLK2	0.33171316
99	MAP2K7	0.32021467
100	PDK2	0.31803162

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.04523233
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.89620230
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.79294269
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.72207056
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.47237314
6	Butanoate metabolism_Homo sapiens_hsa00650	2.40341405
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.31843294
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.24973684
9	Phototransduction_Homo sapiens_hsa04744	2.21163875
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.20333282
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.15476205
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.13539341
13	Ether lipid metabolism_Homo sapiens_hsa00565	2.05883116
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.98452884
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.97596658
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.95104901
17	Nicotine addiction_Homo sapiens_hsa05033	1.85222817
18	RNA polymerase_Homo sapiens_hsa03020	1.80482925
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.79637837
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.78005725
21	Basal transcription factors_Homo sapiens_hsa03022	1.75802358
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.71606772
23	RNA degradation_Homo sapiens_hsa03018	1.60144343
24	ABC transporters_Homo sapiens_hsa02010	1.56138984
25	Taste transduction_Homo sapiens_hsa04742	1.54321699
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.52837911
27	Caffeine metabolism_Homo sapiens_hsa00232	1.49015330
28	Regulation of autophagy_Homo sapiens_hsa04140	1.33074819
29	One carbon pool by folate_Homo sapiens_hsa00670	1.32367401
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.32351260
31	Lysine degradation_Homo sapiens_hsa00310	1.24690693
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.14151320
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10130289
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.06006557
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04993411
36	Olfactory transduction_Homo sapiens_hsa04740	1.03134492
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01282284
38	Fat digestion and absorption_Homo sapiens_hsa04975	1.00818359
39	Protein export_Homo sapiens_hsa03060	1.00579720
40	Asthma_Homo sapiens_hsa05310	1.00200792
41	Sulfur relay system_Homo sapiens_hsa04122	0.98210778
42	Propanoate metabolism_Homo sapiens_hsa00640	0.95764872
43	Peroxisome_Homo sapiens_hsa04146	0.95111200
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94615787
45	Base excision repair_Homo sapiens_hsa03410	0.93302883
46	Mismatch repair_Homo sapiens_hsa03430	0.88897837
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87764127
48	Morphine addiction_Homo sapiens_hsa05032	0.87182578
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86370007
50	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.83590786
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.82889106
52	Serotonergic synapse_Homo sapiens_hsa04726	0.80170948
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79812397
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78466434
55	Circadian rhythm_Homo sapiens_hsa04710	0.77047017
56	RNA transport_Homo sapiens_hsa03013	0.76038725
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75670868
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.74678209
59	Insulin secretion_Homo sapiens_hsa04911	0.73484514
60	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.70525696
61	Parkinsons disease_Homo sapiens_hsa05012	0.69658653
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68060226
63	Circadian entrainment_Homo sapiens_hsa04713	0.67070984
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.66329551
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65880975
66	Purine metabolism_Homo sapiens_hsa00230	0.64117370
67	Huntingtons disease_Homo sapiens_hsa05016	0.62484245
68	Graft-versus-host disease_Homo sapiens_hsa05332	0.61628482
69	GABAergic synapse_Homo sapiens_hsa04727	0.60313578
70	Retinol metabolism_Homo sapiens_hsa00830	0.59928242
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59365118
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58547659
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55728208
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55277943
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54633058
76	DNA replication_Homo sapiens_hsa03030	0.52478229
77	Allograft rejection_Homo sapiens_hsa05330	0.51250141
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.50971273
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48665397
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.48224704
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47561756
82	Salivary secretion_Homo sapiens_hsa04970	0.47315606
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.44706213
84	Metabolic pathways_Homo sapiens_hsa01100	0.43783403
85	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.43693071
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43433873
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.43418081
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41116045
89	Cholinergic synapse_Homo sapiens_hsa04725	0.39806475
90	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39646085
91	Long-term depression_Homo sapiens_hsa04730	0.39222627
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.37873515
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36694100
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36493327
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35131894
96	p53 signaling pathway_Homo sapiens_hsa04115	0.34096002
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33535062
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32197538
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31936379
100	Alzheimers disease_Homo sapiens_hsa05010	0.30663344

ZNF789

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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