ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.50638517
2	response to pheromone (GO:0019236)	4.28018379
3	gamma-aminobutyric acid transport (GO:0015812)	4.13084938
4	platelet dense granule organization (GO:0060155)	4.00664795
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73648320
6	epithelial cilium movement (GO:0003351)	3.69895295
7	DNA double-strand break processing (GO:0000729)	3.60491902
8	L-fucose catabolic process (GO:0042355)	3.54650386
9	fucose catabolic process (GO:0019317)	3.54650386
10	L-fucose metabolic process (GO:0042354)	3.54650386
11	negative regulation of telomere maintenance (GO:0032205)	3.51287136
12	protein-cofactor linkage (GO:0018065)	3.47551620
13	neural tube formation (GO:0001841)	3.44452082
14	protein localization to cilium (GO:0061512)	3.43001037
15	protein complex biogenesis (GO:0070271)	3.40866821
16	DNA integration (GO:0015074)	3.33128479
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.31489735
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.19927134
19	indolalkylamine metabolic process (GO:0006586)	3.18994551
20	cilium morphogenesis (GO:0060271)	3.18084699
21	protein polyglutamylation (GO:0018095)	3.17017130
22	indole-containing compound catabolic process (GO:0042436)	3.11134333
23	indolalkylamine catabolic process (GO:0046218)	3.11134333
24	tryptophan catabolic process (GO:0006569)	3.11134333
25	nonmotile primary cilium assembly (GO:0035058)	3.08182897
26	cilium movement (GO:0003341)	3.07304647
27	axoneme assembly (GO:0035082)	3.06856688
28	intraciliary transport (GO:0042073)	3.05370637
29	mannosylation (GO:0097502)	3.05234395
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.04513658
31	NADH dehydrogenase complex assembly (GO:0010257)	3.04513658
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.04513658
33	ubiquinone metabolic process (GO:0006743)	3.02519873
34	ubiquinone biosynthetic process (GO:0006744)	3.02185616
35	pyrimidine nucleobase catabolic process (GO:0006208)	2.96882267
36	DNA deamination (GO:0045006)	2.96704834
37	preassembly of GPI anchor in ER membrane (GO:0016254)	2.95342175
38	cellular ketone body metabolic process (GO:0046950)	2.94870504
39	respiratory chain complex IV assembly (GO:0008535)	2.93419299
40	somite rostral/caudal axis specification (GO:0032525)	2.92383821
41	regulation of hexokinase activity (GO:1903299)	2.92037495
42	regulation of glucokinase activity (GO:0033131)	2.92037495
43	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.91682722
44	cilium organization (GO:0044782)	2.90788633
45	organelle disassembly (GO:1903008)	2.89754121
46	establishment of protein localization to Golgi (GO:0072600)	2.86861191
47	regulation of cilium movement (GO:0003352)	2.85177096
48	cilium assembly (GO:0042384)	2.83617636
49	kynurenine metabolic process (GO:0070189)	2.83195226
50	detection of light stimulus involved in visual perception (GO:0050908)	2.81638751
51	detection of light stimulus involved in sensory perception (GO:0050962)	2.81638751
52	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.80794054
53	recombinational repair (GO:0000725)	2.77038113
54	synaptic transmission, cholinergic (GO:0007271)	2.74324901
55	tryptophan metabolic process (GO:0006568)	2.72994988
56	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.71914352
57	double-strand break repair via homologous recombination (GO:0000724)	2.70280489
58	peptidyl-histidine modification (GO:0018202)	2.70255669
59	protein import into peroxisome matrix (GO:0016558)	2.69517409
60	replication fork processing (GO:0031297)	2.68818762
61	retinal cone cell development (GO:0046549)	2.68103513
62	protein K11-linked deubiquitination (GO:0035871)	2.67778352
63	cytochrome complex assembly (GO:0017004)	2.67598866
64	protein neddylation (GO:0045116)	2.65851777
65	somite development (GO:0061053)	2.64371590
66	GPI anchor metabolic process (GO:0006505)	2.62901273
67	protein targeting to Golgi (GO:0000042)	2.62643976
68	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.62013055
69	regulation of telomere maintenance (GO:0032204)	2.60350582
70	cornea development in camera-type eye (GO:0061303)	2.60239592
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.59880702
72	regulation of action potential (GO:0098900)	2.59797750
73	cilium or flagellum-dependent cell motility (GO:0001539)	2.59377272
74	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.59242128
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.59242128
76	seminiferous tubule development (GO:0072520)	2.59138482
77	reciprocal DNA recombination (GO:0035825)	2.59123091
78	reciprocal meiotic recombination (GO:0007131)	2.59123091
79	ketone body metabolic process (GO:1902224)	2.58723138
80	ribonucleoprotein complex disassembly (GO:0032988)	2.58289683
81	anterograde synaptic vesicle transport (GO:0048490)	2.57301951
82	S-adenosylmethionine metabolic process (GO:0046500)	2.56806100
83	C-terminal protein amino acid modification (GO:0018410)	2.56642644
84	C-terminal protein lipidation (GO:0006501)	2.56485294
85	reflex (GO:0060004)	2.55929760
86	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.55515907
87	piRNA metabolic process (GO:0034587)	2.55269814
88	sulfation (GO:0051923)	2.54090516
89	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.53955586
90	cullin deneddylation (GO:0010388)	2.53697211
91	positive regulation of mitochondrial fission (GO:0090141)	2.50980029
92	intracellular protein transmembrane import (GO:0044743)	2.50484927
93	determination of left/right symmetry (GO:0007368)	2.49807528
94	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49504125
95	sequestering of actin monomers (GO:0042989)	2.49331488
96	nucleobase catabolic process (GO:0046113)	2.48631982
97	protein deneddylation (GO:0000338)	2.47274487
98	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.47118419
99	regulation of mitotic spindle checkpoint (GO:1903504)	2.47118419
100	protein localization to Golgi apparatus (GO:0034067)	2.45591204

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.10658991
2	VDR_22108803_ChIP-Seq_LS180_Human	3.20476403
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.00342256
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.98154022
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.78669134
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.75839954
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63772182
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.49342562
9	FUS_26573619_Chip-Seq_HEK293_Human	2.46669734
10	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34711665
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.29714170
12	EWS_26573619_Chip-Seq_HEK293_Human	2.24865523
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21937730
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.20024426
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.19366511
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.08378709
17	P300_19829295_ChIP-Seq_ESCs_Human	2.07033973
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.06874864
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98022570
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97713577
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92014549
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.84337088
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.80228961
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79766501
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.73221227
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.72376880
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64868286
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64584107
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58308322
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.58308322
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57987930
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55028308
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52916429
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52912206
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52484934
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.51975863
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.51945979
38	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50663367
39	* MYC_18940864_ChIP-ChIP_HL60_Human	1.50333722
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.48938322
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48182238
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47983680
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46117980
44	STAT3_23295773_ChIP-Seq_U87_Human	1.45160210
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45027189
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44854868
47	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43255930
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41299930
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38248553
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36819537
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36256705
52	AR_25329375_ChIP-Seq_VCAP_Human	1.35128975
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35068991
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.34104142
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32850962
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32708679
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31318311
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30956957
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30956957
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29990071
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28573011
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28573011
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28443298
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27882893
65	TCF4_23295773_ChIP-Seq_U87_Human	1.25710273
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22690033
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22690033
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21868223
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.21772427
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19513935
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19200323
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17387844
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17243265
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16529114
75	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15858249
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12945068
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12382078
78	AR_20517297_ChIP-Seq_VCAP_Human	1.09403105
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09375367
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08777832
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07677808
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06975928
83	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06752025
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06626302
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06504838
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06436889
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06244702
88	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05061076
89	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.05049859
90	NCOR_22424771_ChIP-Seq_293T_Human	1.03491672
91	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02766662
92	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02243402
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01317854
94	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.01210795
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99564869
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99052544
97	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98659846
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97801724
99	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.97410434
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.97338611

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.04728183
2	MP0002837_dystrophic_cardiac_calcinosis	2.46899533
3	MP0003880_abnormal_central_pattern	2.45924836
4	MP0002102_abnormal_ear_morphology	2.45675372
5	MP0003195_calcinosis	2.43272871
6	MP0001986_abnormal_taste_sensitivity	2.30047305
7	MP0006276_abnormal_autonomic_nervous	2.23806884
8	MP0001968_abnormal_touch/_nociception	2.17436547
9	MP0003787_abnormal_imprinting	2.16582483
10	MP0001529_abnormal_vocalization	2.12874442
11	MP0005551_abnormal_eye_electrophysiolog	2.09045464
12	MP0002638_abnormal_pupillary_reflex	2.04151298
13	MP0009046_muscle_twitch	1.98388685
14	MP0001984_abnormal_olfaction	1.90450872
15	MP0006072_abnormal_retinal_apoptosis	1.88899189
16	MP0004142_abnormal_muscle_tone	1.88123389
17	MP0002736_abnormal_nociception_after	1.79117286
18	MP0005253_abnormal_eye_physiology	1.78042700
19	MP0009745_abnormal_behavioral_response	1.77726294
20	MP0004133_heterotaxia	1.76539165
21	MP0000569_abnormal_digit_pigmentation	1.71314612
22	MP0002272_abnormal_nervous_system	1.68193240
23	MP0008789_abnormal_olfactory_epithelium	1.63051766
24	MP0005645_abnormal_hypothalamus_physiol	1.62784511
25	MP0000372_irregular_coat_pigmentation	1.62194404
26	MP0004885_abnormal_endolymph	1.59899065
27	MP0006292_abnormal_olfactory_placode	1.59438998
28	MP0003136_yellow_coat_color	1.55047746
29	MP0004145_abnormal_muscle_electrophysio	1.54181935
30	MP0004043_abnormal_pH_regulation	1.53134018
31	MP0003011_delayed_dark_adaptation	1.52981709
32	MP0010386_abnormal_urinary_bladder	1.49964674
33	MP0001486_abnormal_startle_reflex	1.48524363
34	MP0002254_reproductive_system_inflammat	1.47400186
35	MP0005187_abnormal_penis_morphology	1.45118141
36	MP0005646_abnormal_pituitary_gland	1.44998650
37	MP0002938_white_spotting	1.44295945
38	MP0008872_abnormal_physiological_respon	1.43946155
39	MP0000631_abnormal_neuroendocrine_gland	1.41159526
40	MP0004147_increased_porphyrin_level	1.39889887
41	MP0008995_early_reproductive_senescence	1.36623666
42	MP0000427_abnormal_hair_cycle	1.35738036
43	MP0008058_abnormal_DNA_repair	1.35415771
44	MP0002234_abnormal_pharynx_morphology	1.35016709
45	MP0005167_abnormal_blood-brain_barrier	1.32213681
46	MP0008875_abnormal_xenobiotic_pharmacok	1.31783088
47	MP0002876_abnormal_thyroid_physiology	1.31623231
48	MP0005084_abnormal_gallbladder_morpholo	1.30831415
49	MP0000778_abnormal_nervous_system	1.30796059
50	MP0003646_muscle_fatigue	1.30440331
51	MP0002735_abnormal_chemical_nociception	1.30386294
52	MP0003121_genomic_imprinting	1.28412578
53	MP0005394_taste/olfaction_phenotype	1.27260230
54	MP0005499_abnormal_olfactory_system	1.27260230
55	MP0004215_abnormal_myocardial_fiber	1.27188657
56	MP0002557_abnormal_social/conspecific_i	1.26229663
57	MP0005423_abnormal_somatic_nervous	1.24994513
58	MP0002572_abnormal_emotion/affect_behav	1.24541377
59	MP0001485_abnormal_pinna_reflex	1.21866815
60	MP0002751_abnormal_autonomic_nervous	1.20856808
61	MP0003122_maternal_imprinting	1.15579982
62	MP0004924_abnormal_behavior	1.14032119
63	MP0005386_behavior/neurological_phenoty	1.14032119
64	MP0002067_abnormal_sensory_capabilities	1.13407644
65	MP0006035_abnormal_mitochondrial_morpho	1.12377494
66	MP0000647_abnormal_sebaceous_gland	1.12367512
67	MP0003635_abnormal_synaptic_transmissio	1.11020927
68	MP0002653_abnormal_ependyma_morphology	1.08844027
69	MP0005075_abnormal_melanosome_morpholog	1.07583282
70	MP0001501_abnormal_sleep_pattern	1.06204898
71	MP0002733_abnormal_thermal_nociception	1.06005069
72	MP0002064_seizures	1.05756888
73	MP0002909_abnormal_adrenal_gland	1.02635050
74	MP0005410_abnormal_fertilization	1.00727242
75	MP0001293_anophthalmia	0.99606622
76	MP0000383_abnormal_hair_follicle	0.99412157
77	MP0002928_abnormal_bile_duct	0.99176416
78	MP0002184_abnormal_innervation	0.98896366
79	MP0001970_abnormal_pain_threshold	0.98616576
80	MP0002734_abnormal_mechanical_nocicepti	0.98522944
81	MP0002277_abnormal_respiratory_mucosa	0.96495516
82	MP0005195_abnormal_posterior_eye	0.95965208
83	MP0002063_abnormal_learning/memory/cond	0.95556863
84	MP0002752_abnormal_somatic_nervous	0.95550472
85	MP0003567_abnormal_fetal_cardiomyocyte	0.95355035
86	MP0002095_abnormal_skin_pigmentation	0.94037026
87	MP0009697_abnormal_copulation	0.92603873
88	MP0004742_abnormal_vestibular_system	0.92302571
89	MP0002160_abnormal_reproductive_system	0.90419377
90	MP0003718_maternal_effect	0.89275677
91	MP0008775_abnormal_heart_ventricle	0.88289808
92	MP0000026_abnormal_inner_ear	0.87622343
93	MP0003698_abnormal_male_reproductive	0.87546451
94	MP0003283_abnormal_digestive_organ	0.86395516
95	MP0005389_reproductive_system_phenotype	0.81894713
96	MP0001929_abnormal_gametogenesis	0.80651479
97	MP0003119_abnormal_digestive_system	0.79933991
98	MP0000955_abnormal_spinal_cord	0.79046369
99	MP0005367_renal/urinary_system_phenotyp	0.78924000
100	MP0000516_abnormal_urinary_system	0.78924000

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.18817768
2	Molar tooth sign on MRI (HP:0002419)	4.10856435
3	Abnormality of midbrain morphology (HP:0002418)	4.10856435
4	True hermaphroditism (HP:0010459)	4.06867541
5	Pancreatic fibrosis (HP:0100732)	3.99313108
6	Nephronophthisis (HP:0000090)	3.92418961
7	Type II lissencephaly (HP:0007260)	3.54466755
8	Chronic hepatic failure (HP:0100626)	3.41392182
9	Abnormality of the renal medulla (HP:0100957)	3.34677210
10	Abnormality of the renal cortex (HP:0011035)	3.32643551
11	Medial flaring of the eyebrow (HP:0010747)	3.17326987
12	Hyperventilation (HP:0002883)	2.85376858
13	Lissencephaly (HP:0001339)	2.84391447
14	Congenital stationary night blindness (HP:0007642)	2.83357024
15	Renal cortical cysts (HP:0000803)	2.76806026
16	Abnormal biliary tract physiology (HP:0012439)	2.74790322
17	Bile duct proliferation (HP:0001408)	2.74790322
18	Abolished electroretinogram (ERG) (HP:0000550)	2.73681372
19	Cerebellar dysplasia (HP:0007033)	2.55580997
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.53251983
21	Gait imbalance (HP:0002141)	2.47428047
22	Hemiparesis (HP:0001269)	2.45807575
23	Retinal dysplasia (HP:0007973)	2.45571518
24	Attenuation of retinal blood vessels (HP:0007843)	2.43904196
25	Congenital primary aphakia (HP:0007707)	2.43121597
26	Cystic liver disease (HP:0006706)	2.42731737
27	Methylmalonic acidemia (HP:0002912)	2.41280843
28	Tubular atrophy (HP:0000092)	2.41171463
29	Nephrogenic diabetes insipidus (HP:0009806)	2.41039250
30	Acute necrotizing encephalopathy (HP:0006965)	2.37474769
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.36013367
32	Polydipsia (HP:0001959)	2.35099867
33	Abnormal drinking behavior (HP:0030082)	2.35099867
34	Inability to walk (HP:0002540)	2.35057674
35	Sclerocornea (HP:0000647)	2.33645302
36	Increased CSF lactate (HP:0002490)	2.33014447
37	Hypothermia (HP:0002045)	2.31764364
38	Progressive inability to walk (HP:0002505)	2.25281180
39	Mitochondrial inheritance (HP:0001427)	2.24824426
40	Keratoconus (HP:0000563)	2.24184929
41	Increased corneal curvature (HP:0100692)	2.24184929
42	Abnormality of the labia minora (HP:0012880)	2.21862920
43	Anencephaly (HP:0002323)	2.21605596
44	Genital tract atresia (HP:0001827)	2.17225044
45	Occipital encephalocele (HP:0002085)	2.17067076
46	3-Methylglutaconic aciduria (HP:0003535)	2.16837231
47	Thyroid-stimulating hormone excess (HP:0002925)	2.16707700
48	Male pseudohermaphroditism (HP:0000037)	2.16425556
49	Large for gestational age (HP:0001520)	2.15787866
50	Methylmalonic aciduria (HP:0012120)	2.15300628
51	Abnormal ciliary motility (HP:0012262)	2.14062927
52	Postaxial foot polydactyly (HP:0001830)	2.13791304
53	Congenital hepatic fibrosis (HP:0002612)	2.12721424
54	Lipid accumulation in hepatocytes (HP:0006561)	2.12247240
55	Progressive macrocephaly (HP:0004481)	2.11754614
56	Abnormality of alanine metabolism (HP:0010916)	2.11726235
57	Hyperalaninemia (HP:0003348)	2.11726235
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.11726235
59	Short tibia (HP:0005736)	2.10333070
60	Acute encephalopathy (HP:0006846)	2.09580875
61	Vaginal atresia (HP:0000148)	2.08663845
62	Colon cancer (HP:0003003)	2.08304501
63	Intestinal atresia (HP:0011100)	2.07652526
64	Abnormal mitochondria in muscle tissue (HP:0008316)	2.06394827
65	Abnormal respiratory epithelium morphology (HP:0012253)	2.05078298
66	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05078298
67	Polyuria (HP:0000103)	2.02269896
68	Increased hepatocellular lipid droplets (HP:0006565)	2.00976172
69	Optic nerve hypoplasia (HP:0000609)	2.00866870
70	Pachygyria (HP:0001302)	2.00341756
71	Ketoacidosis (HP:0001993)	1.99765156
72	Absent/shortened dynein arms (HP:0200106)	1.97919429
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97919429
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.96841936
75	Progressive cerebellar ataxia (HP:0002073)	1.95395452
76	Postaxial hand polydactyly (HP:0001162)	1.95038611
77	Focal motor seizures (HP:0011153)	1.95019017
78	Gaze-evoked nystagmus (HP:0000640)	1.94658686
79	Absent speech (HP:0001344)	1.93640890
80	Hepatocellular necrosis (HP:0001404)	1.91893522
81	Furrowed tongue (HP:0000221)	1.90876253
82	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90255806
83	Disproportionate short-trunk short stature (HP:0003521)	1.90010352
84	Pendular nystagmus (HP:0012043)	1.87586038
85	Abnormal rod and cone electroretinograms (HP:0008323)	1.87280897
86	Oligodactyly (hands) (HP:0001180)	1.84228256
87	Optic disc pallor (HP:0000543)	1.82407756
88	Increased serum lactate (HP:0002151)	1.80970568
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.80592477
90	Abnormal protein glycosylation (HP:0012346)	1.80300460
91	Abnormal glycosylation (HP:0012345)	1.80300460
92	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.80300460
93	Abnormal protein N-linked glycosylation (HP:0012347)	1.80300460
94	Polyphagia (HP:0002591)	1.79510707
95	Decreased central vision (HP:0007663)	1.78627087
96	Drooling (HP:0002307)	1.78541247
97	Limb dystonia (HP:0002451)	1.77794319
98	Stomach cancer (HP:0012126)	1.76732620
99	Broad-based gait (HP:0002136)	1.76241089
100	Tachypnea (HP:0002789)	1.74430701

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.85138721
2	MAP4K2	3.09670413
3	MAP3K4	2.82579611
4	WNK3	2.77697585
5	ADRBK2	2.63128785
6	GRK1	2.46315605
7	BMPR1B	2.29561394
8	ZAK	2.23522890
9	MAP2K7	2.21743227
10	PINK1	2.09956687
11	CASK	2.07156396
12	INSRR	2.04543298
13	TAOK3	1.97185818
14	TRIM28	1.93858950
15	NUAK1	1.91371443
16	BCR	1.75422412
17	STK38L	1.73657039
18	WNK4	1.69876589
19	MKNK2	1.68196943
20	TLK1	1.67531744
21	MAPK13	1.59073175
22	OXSR1	1.51565801
23	ACVR1B	1.42065828
24	TXK	1.41940725
25	STK39	1.39174713
26	MAP2K4	1.39005976
27	PLK2	1.35061617
28	DAPK2	1.33554991
29	CSNK1A1L	1.29233756
30	CSNK1G1	1.29226310
31	ERBB3	1.27853494
32	CSNK1G3	1.27602030
33	CSNK1G2	1.25847514
34	MARK1	1.22862528
35	OBSCN	1.20681199
36	BCKDK	1.19092196
37	DYRK2	1.15478283
38	PAK3	1.12826382
39	TIE1	1.08077521
40	MAP3K6	1.03400088
41	VRK1	1.01687691
42	PRKCE	1.01621255
43	SRPK1	0.98889713
44	CAMKK2	0.98283259
45	PRKCG	0.97028249
46	ADRBK1	0.92704411
47	AKT3	0.91510893
48	MKNK1	0.87463855
49	MAP2K6	0.86999428
50	EPHA4	0.86152253
51	CCNB1	0.85584584
52	CDK19	0.81288421
53	NTRK2	0.80005348
54	TNIK	0.78879030
55	PIK3CA	0.77925114
56	BRSK2	0.75723903
57	NEK1	0.75703801
58	MINK1	0.74501638
59	PHKG2	0.72264298
60	PHKG1	0.72264298
61	TAF1	0.68008019
62	BRD4	0.67883518
63	PTK2B	0.67787540
64	GRK7	0.63620304
65	PLK3	0.61078262
66	MST4	0.60846047
67	MUSK	0.60529506
68	VRK2	0.59208464
69	NTRK3	0.58948304
70	MAP3K12	0.58271946
71	RPS6KA5	0.57766536
72	EIF2AK3	0.56130358
73	CAMK2A	0.55990718
74	STK38	0.54292478
75	DYRK3	0.53976368
76	LIMK1	0.53405483
77	PLK4	0.53385618
78	TEC	0.51454936
79	PRKACA	0.49373672
80	TGFBR1	0.49235040
81	RPS6KA4	0.48633301
82	CSNK1A1	0.44780144
83	FGFR2	0.44477362
84	PRKCI	0.43300014
85	PNCK	0.43261175
86	NME1	0.41419114
87	CSNK1D	0.40442944
88	STK16	0.39566614
89	PLK1	0.37888409
90	PRKG1	0.36577900
91	MAP3K5	0.36233491
92	PRKCQ	0.36229990
93	FER	0.36026570
94	PKN1	0.35696193
95	PRKAA1	0.35336705
96	ATM	0.34930740
97	IRAK1	0.34481295
98	DYRK1A	0.33730809
99	ATR	0.33631753
100	PRKCA	0.32930017

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	2.79956182
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.73648453
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68366255
4	Phototransduction_Homo sapiens_hsa04744	2.58714403
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.50366750
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.41062677
7	Butanoate metabolism_Homo sapiens_hsa00650	2.37076933
8	Propanoate metabolism_Homo sapiens_hsa00640	2.23136542
9	Nicotine addiction_Homo sapiens_hsa05033	2.19949865
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.12706387
11	RNA polymerase_Homo sapiens_hsa03020	2.09376133
12	Parkinsons disease_Homo sapiens_hsa05012	2.08161192
13	Basal transcription factors_Homo sapiens_hsa03022	2.05029421
14	Caffeine metabolism_Homo sapiens_hsa00232	2.01456580
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.92702053
16	Regulation of autophagy_Homo sapiens_hsa04140	1.82691115
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77501065
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74272449
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.74122839
20	Homologous recombination_Homo sapiens_hsa03440	1.73755583
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.69994102
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68671033
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.68367233
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65544682
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65348190
26	Peroxisome_Homo sapiens_hsa04146	1.64888617
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.62391701
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.61919547
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.50512469
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.49234061
31	Huntingtons disease_Homo sapiens_hsa05016	1.45061013
32	RNA degradation_Homo sapiens_hsa03018	1.42446534
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29799538
34	Alzheimers disease_Homo sapiens_hsa05010	1.27504909
35	Proteasome_Homo sapiens_hsa03050	1.25674031
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23949299
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.16887254
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.14397893
39	GABAergic synapse_Homo sapiens_hsa04727	1.14151843
40	Olfactory transduction_Homo sapiens_hsa04740	1.13045425
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.12485449
42	Taste transduction_Homo sapiens_hsa04742	1.10715203
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04362925
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04225875
45	Morphine addiction_Homo sapiens_hsa05032	1.01633289
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99416094
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.98357098
48	Retinol metabolism_Homo sapiens_hsa00830	0.97557729
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96290400
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92050934
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89780849
52	Purine metabolism_Homo sapiens_hsa00230	0.89493921
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.87142673
54	ABC transporters_Homo sapiens_hsa02010	0.85113232
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84560543
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83391699
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82721346
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.77885937
59	Insulin secretion_Homo sapiens_hsa04911	0.77718601
60	Circadian rhythm_Homo sapiens_hsa04710	0.77499569
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.76477344
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76242162
63	Fatty acid elongation_Homo sapiens_hsa00062	0.75209305
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75174956
65	Serotonergic synapse_Homo sapiens_hsa04726	0.74830785
66	Circadian entrainment_Homo sapiens_hsa04713	0.74780223
67	Metabolic pathways_Homo sapiens_hsa01100	0.73224733
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70681092
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70490169
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.69881909
71	One carbon pool by folate_Homo sapiens_hsa00670	0.68641579
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65870018
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.64896364
74	RNA transport_Homo sapiens_hsa03013	0.62670450
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.62502371
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59005398
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.57188637
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55570170
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55526583
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55343862
81	Sulfur metabolism_Homo sapiens_hsa00920	0.54559110
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.51445529
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47740653
84	Fatty acid degradation_Homo sapiens_hsa00071	0.47214320
85	Salivary secretion_Homo sapiens_hsa04970	0.47213531
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45742535
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.42540583
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.42428689
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.41166810
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.40164894
91	Histidine metabolism_Homo sapiens_hsa00340	0.38807478
92	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38150310
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37253104
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36639726
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31547839
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.29434698
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28532455
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.27346004
99	Spliceosome_Homo sapiens_hsa03040	0.25732690
100	Amphetamine addiction_Homo sapiens_hsa05031	0.22116792

ZNF790

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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