ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.51365447
2	L-fucose catabolic process (GO:0042355)	4.19313242
3	fucose catabolic process (GO:0019317)	4.19313242
4	L-fucose metabolic process (GO:0042354)	4.19313242
5	neural tube formation (GO:0001841)	3.77895497
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.61359131
7	nonmotile primary cilium assembly (GO:0035058)	3.54949946
8	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.44369255
9	regulation of translation, ncRNA-mediated (GO:0045974)	3.44369255
10	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.44369255
11	cellular ketone body metabolic process (GO:0046950)	3.39403753
12	indole-containing compound catabolic process (GO:0042436)	3.35159432
13	indolalkylamine catabolic process (GO:0046218)	3.35159432
14	tryptophan catabolic process (GO:0006569)	3.35159432
15	kidney morphogenesis (GO:0060993)	3.34173288
16	kynurenine metabolic process (GO:0070189)	3.26648959
17	detection of light stimulus involved in visual perception (GO:0050908)	3.25556069
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.25556069
19	cornea development in camera-type eye (GO:0061303)	3.24498305
20	response to pheromone (GO:0019236)	3.20947642
21	gamma-aminobutyric acid transport (GO:0015812)	3.20873403
22	indolalkylamine metabolic process (GO:0006586)	3.19404359
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14651169
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.12860617
25	negative regulation of mast cell activation (GO:0033004)	3.11965621
26	negative regulation of telomere maintenance (GO:0032205)	3.11443641
27	ketone body metabolic process (GO:1902224)	3.08125548
28	head development (GO:0060322)	3.01383012
29	protein K11-linked deubiquitination (GO:0035871)	2.98956911
30	somite development (GO:0061053)	2.98444864
31	protein polyglutamylation (GO:0018095)	2.96824287
32	neuronal action potential (GO:0019228)	2.94292786
33	protein localization to cilium (GO:0061512)	2.92242639
34	DNA deamination (GO:0045006)	2.91119972
35	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90439342
36	behavioral response to ethanol (GO:0048149)	2.90154924
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.87303520
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.87303520
39	NADH dehydrogenase complex assembly (GO:0010257)	2.87303520
40	epithelial cilium movement (GO:0003351)	2.86396455
41	presynaptic membrane assembly (GO:0097105)	2.85871362
42	regulation of telomere maintenance (GO:0032204)	2.83859389
43	tryptophan metabolic process (GO:0006568)	2.83776503
44	ubiquinone biosynthetic process (GO:0006744)	2.83325884
45	regulation of glucokinase activity (GO:0033131)	2.81036221
46	regulation of hexokinase activity (GO:1903299)	2.81036221
47	cilium morphogenesis (GO:0060271)	2.80727426
48	axoneme assembly (GO:0035082)	2.80155692
49	sulfation (GO:0051923)	2.79616298
50	endoderm formation (GO:0001706)	2.77896882
51	cilium organization (GO:0044782)	2.76539353
52	protein complex biogenesis (GO:0070271)	2.76442765
53	rRNA catabolic process (GO:0016075)	2.76137289
54	ubiquinone metabolic process (GO:0006743)	2.75595731
55	platelet dense granule organization (GO:0060155)	2.73638992
56	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.71760403
57	cilium assembly (GO:0042384)	2.70470214
58	primary amino compound metabolic process (GO:1901160)	2.70110443
59	regulation of action potential (GO:0098900)	2.69335680
60	indole-containing compound metabolic process (GO:0042430)	2.65743634
61	respiratory chain complex IV assembly (GO:0008535)	2.65374590
62	photoreceptor cell maintenance (GO:0045494)	2.64031554
63	nucleobase catabolic process (GO:0046113)	2.62274646
64	spinal cord motor neuron differentiation (GO:0021522)	2.60878470
65	serotonin metabolic process (GO:0042428)	2.60660550
66	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.60227784
67	synaptic transmission, cholinergic (GO:0007271)	2.59688350
68	prenylation (GO:0097354)	2.57019949
69	protein prenylation (GO:0018342)	2.57019949
70	cAMP catabolic process (GO:0006198)	2.56857562
71	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.56028212
72	DNA double-strand break processing (GO:0000729)	2.55405697
73	mitochondrial respiratory chain complex assembly (GO:0033108)	2.55116312
74	presynaptic membrane organization (GO:0097090)	2.54537095
75	cellular biogenic amine catabolic process (GO:0042402)	2.53121783
76	amine catabolic process (GO:0009310)	2.53121783
77	establishment of protein localization to Golgi (GO:0072600)	2.52897473
78	reflex (GO:0060004)	2.51283979
79	somite rostral/caudal axis specification (GO:0032525)	2.50900708
80	protein-cofactor linkage (GO:0018065)	2.50710651
81	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.49685261
82	cell differentiation in spinal cord (GO:0021515)	2.49086598
83	postsynaptic membrane organization (GO:0001941)	2.48991369
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.48187901
85	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.47951380
86	replication fork processing (GO:0031297)	2.47142382
87	water-soluble vitamin biosynthetic process (GO:0042364)	2.46397844
88	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.45364154
89	photoreceptor cell development (GO:0042461)	2.44226577
90	retina layer formation (GO:0010842)	2.43446792
91	regulation of mesoderm development (GO:2000380)	2.43416756
92	neuron cell-cell adhesion (GO:0007158)	2.43361984
93	mannosylation (GO:0097502)	2.42214787
94	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.41767734
95	forebrain neuron differentiation (GO:0021879)	2.41495023
96	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.41214053
97	retinal ganglion cell axon guidance (GO:0031290)	2.40102890
98	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.39315333
99	fucosylation (GO:0036065)	2.39255927
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.38753452

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.17144734
2	VDR_22108803_ChIP-Seq_LS180_Human	3.23455756
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.01288632
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.92381685
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.81956587
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.68809046
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.68132742
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62444401
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34020399
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30772396
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.29298817
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.28718249
13	EWS_26573619_Chip-Seq_HEK293_Human	2.26140469
14	FUS_26573619_Chip-Seq_HEK293_Human	2.22203196
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16187628
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.16026251
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.03131955
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02320379
19	P300_19829295_ChIP-Seq_ESCs_Human	2.00402104
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.86868904
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.78899933
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.72167749
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71784358
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68089436
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65858665
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64514049
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63914045
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63787703
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62217684
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60140520
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60076643
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59906219
33	AR_25329375_ChIP-Seq_VCAP_Human	1.58604337
34	STAT3_23295773_ChIP-Seq_U87_Human	1.55629941
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55343611
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.55107240
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53827017
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.53168199
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53066501
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52134907
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.52134907
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48863160
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.48542032
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48276215
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46581388
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.45280382
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41678190
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41240585
49	TCF4_23295773_ChIP-Seq_U87_Human	1.39117988
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37685319
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37335932
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.37335932
53	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.36656549
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36594848
55	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.35269880
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32582443
57	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.31158213
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.30608311
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29213985
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27128271
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.25440433
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25185802
63	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.23581042
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23467183
65	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22978217
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22702297
67	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.21906037
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20819412
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19649495
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19649495
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19528627
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19130537
73	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18154917
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13637137
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12658252
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12658252
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12041435
78	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12038534
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11799818
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09564596
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09340391
82	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07987788
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06197945
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06109654
85	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05354365
86	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05221027
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04514042
88	NCOR_22424771_ChIP-Seq_293T_Human	1.03474288
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02651619
90	ELK1_19687146_ChIP-ChIP_HELA_Human	1.02182544
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00882948
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00833230
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98969389
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98961757
95	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.98604061
96	* VDR_23849224_ChIP-Seq_CD4+_Human	0.97434401
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97309813
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.96460024
99	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.96328154
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96027356

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.89028223
2	MP0008877_abnormal_DNA_methylation	2.83015391
3	MP0002102_abnormal_ear_morphology	2.70613011
4	MP0003787_abnormal_imprinting	2.70194075
5	MP0003880_abnormal_central_pattern	2.62349418
6	MP0003195_calcinosis	2.50449034
7	MP0000569_abnormal_digit_pigmentation	2.42874753
8	MP0005551_abnormal_eye_electrophysiolog	2.34280830
9	MP0001968_abnormal_touch/_nociception	2.27457941
10	MP0009046_muscle_twitch	2.14385097
11	MP0001986_abnormal_taste_sensitivity	2.12118077
12	MP0003890_abnormal_embryonic-extraembry	2.04940508
13	MP0003136_yellow_coat_color	1.99112189
14	MP0006072_abnormal_retinal_apoptosis	1.98368227
15	MP0006276_abnormal_autonomic_nervous	1.94231525
16	MP0004142_abnormal_muscle_tone	1.92513054
17	MP0003646_muscle_fatigue	1.91154867
18	MP0002837_dystrophic_cardiac_calcinosis	1.90475203
19	MP0009745_abnormal_behavioral_response	1.90396624
20	MP0004043_abnormal_pH_regulation	1.87541661
21	MP0002736_abnormal_nociception_after	1.81628672
22	MP0002272_abnormal_nervous_system	1.79382677
23	MP0005253_abnormal_eye_physiology	1.75191632
24	MP0004885_abnormal_endolymph	1.74915025
25	MP0001485_abnormal_pinna_reflex	1.73328419
26	MP0002638_abnormal_pupillary_reflex	1.72687862
27	MP0004133_heterotaxia	1.72397420
28	MP0005645_abnormal_hypothalamus_physiol	1.65450677
29	MP0008872_abnormal_physiological_respon	1.64082057
30	MP0000427_abnormal_hair_cycle	1.62205106
31	MP0000631_abnormal_neuroendocrine_gland	1.55952231
32	MP0004742_abnormal_vestibular_system	1.52508682
33	MP0004147_increased_porphyrin_level	1.49921935
34	MP0008875_abnormal_xenobiotic_pharmacok	1.49564077
35	MP0001486_abnormal_startle_reflex	1.49153901
36	MP0000778_abnormal_nervous_system	1.47703253
37	MP0002653_abnormal_ependyma_morphology	1.46780737
38	MP0002735_abnormal_chemical_nociception	1.45351815
39	MP0002572_abnormal_emotion/affect_behav	1.43456304
40	MP0001984_abnormal_olfaction	1.43227811
41	MP0003121_genomic_imprinting	1.41278637
42	MP0001501_abnormal_sleep_pattern	1.40429994
43	MP0005174_abnormal_tail_pigmentation	1.38958096
44	MP0002557_abnormal_social/conspecific_i	1.38211834
45	MP0008995_early_reproductive_senescence	1.35802893
46	MP0002876_abnormal_thyroid_physiology	1.34936027
47	MP0005423_abnormal_somatic_nervous	1.32895764
48	MP0001529_abnormal_vocalization	1.32613546
49	MP0003011_delayed_dark_adaptation	1.31474576
50	MP0001188_hyperpigmentation	1.29595691
51	MP0002064_seizures	1.26691904
52	MP0005646_abnormal_pituitary_gland	1.26446655
53	MP0002067_abnormal_sensory_capabilities	1.24691449
54	MP0000372_irregular_coat_pigmentation	1.24497617
55	MP0003635_abnormal_synaptic_transmissio	1.23642372
56	MP0004924_abnormal_behavior	1.23231446
57	MP0005386_behavior/neurological_phenoty	1.23231446
58	MP0002938_white_spotting	1.23032618
59	MP0003122_maternal_imprinting	1.19375425
60	MP0001970_abnormal_pain_threshold	1.17391537
61	MP0002063_abnormal_learning/memory/cond	1.17115061
62	MP0004145_abnormal_muscle_electrophysio	1.16075406
63	MP0002734_abnormal_mechanical_nocicepti	1.16025389
64	MP0001502_abnormal_circadian_rhythm	1.13241622
65	MP0008789_abnormal_olfactory_epithelium	1.11825668
66	MP0002928_abnormal_bile_duct	1.09590167
67	MP0002184_abnormal_innervation	1.09409161
68	MP0004215_abnormal_myocardial_fiber	1.09035498
69	MP0002733_abnormal_thermal_nociception	1.07537663
70	MP0002234_abnormal_pharynx_morphology	1.06020729
71	MP0005084_abnormal_gallbladder_morpholo	1.05460830
72	MP0002751_abnormal_autonomic_nervous	1.05203976
73	MP0005195_abnormal_posterior_eye	1.03525817
74	MP0003718_maternal_effect	1.03375814
75	MP0003119_abnormal_digestive_system	1.01550099
76	MP0000383_abnormal_hair_follicle	0.99221333
77	MP0002752_abnormal_somatic_nervous	0.98924513
78	MP0003137_abnormal_impulse_conducting	0.98866082
79	MP0000026_abnormal_inner_ear	0.95112823
80	MP0000955_abnormal_spinal_cord	0.94292642
81	MP0005499_abnormal_olfactory_system	0.94079095
82	MP0005394_taste/olfaction_phenotype	0.94079095
83	MP0002095_abnormal_skin_pigmentation	0.91386517
84	MP0008775_abnormal_heart_ventricle	0.90359984
85	MP0001293_anophthalmia	0.90190098
86	MP0000647_abnormal_sebaceous_gland	0.89846036
87	MP0002160_abnormal_reproductive_system	0.88633866
88	MP0005389_reproductive_system_phenotype	0.87705470
89	MP0000049_abnormal_middle_ear	0.87485400
90	MP0001324_abnormal_eye_pigmentation	0.85114913
91	MP0008961_abnormal_basal_metabolism	0.84906353
92	MP0002822_catalepsy	0.82319064
93	MP0002882_abnormal_neuron_morphology	0.82023227
94	MP0004085_abnormal_heartbeat	0.81942539
95	MP0008058_abnormal_DNA_repair	0.80561455
96	MP0005448_abnormal_energy_balance	0.78037635
97	MP0001963_abnormal_hearing_physiology	0.77644858
98	MP0001919_abnormal_reproductive_system	0.77102311
99	MP0000538_abnormal_urinary_bladder	0.77014804
100	MP0002229_neurodegeneration	0.76918798

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.32540815
2	Abnormality of midbrain morphology (HP:0002418)	4.00879067
3	Molar tooth sign on MRI (HP:0002419)	4.00879067
4	Pancreatic fibrosis (HP:0100732)	3.82559417
5	Congenital stationary night blindness (HP:0007642)	3.80939967
6	Hyperventilation (HP:0002883)	3.69811587
7	True hermaphroditism (HP:0010459)	3.69035050
8	Nephronophthisis (HP:0000090)	3.51352910
9	Type II lissencephaly (HP:0007260)	3.23898216
10	Medial flaring of the eyebrow (HP:0010747)	3.23307289
11	Abnormality of the renal cortex (HP:0011035)	3.08256178
12	Abnormality of the renal medulla (HP:0100957)	3.07502492
13	Abnormality of alanine metabolism (HP:0010916)	3.04279358
14	Hyperalaninemia (HP:0003348)	3.04279358
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.04279358
16	Chronic hepatic failure (HP:0100626)	2.82469993
17	Attenuation of retinal blood vessels (HP:0007843)	2.79290214
18	Lissencephaly (HP:0001339)	2.77312923
19	Gait imbalance (HP:0002141)	2.75073424
20	Protruding tongue (HP:0010808)	2.73717804
21	Inability to walk (HP:0002540)	2.69632898
22	Congenital primary aphakia (HP:0007707)	2.63334584
23	Birth length less than 3rd percentile (HP:0003561)	2.60044109
24	Abnormal drinking behavior (HP:0030082)	2.58583615
25	Polydipsia (HP:0001959)	2.58583615
26	Nephrogenic diabetes insipidus (HP:0009806)	2.57027123
27	Cystic liver disease (HP:0006706)	2.54982693
28	Progressive inability to walk (HP:0002505)	2.53831291
29	Broad-based gait (HP:0002136)	2.52263857
30	Tubular atrophy (HP:0000092)	2.51196564
31	Absent speech (HP:0001344)	2.49103406
32	Large for gestational age (HP:0001520)	2.47518178
33	Cerebellar dysplasia (HP:0007033)	2.47205021
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.45523625
35	Patellar aplasia (HP:0006443)	2.42765098
36	Gaze-evoked nystagmus (HP:0000640)	2.37355318
37	Progressive cerebellar ataxia (HP:0002073)	2.37351616
38	Abolished electroretinogram (ERG) (HP:0000550)	2.35686078
39	Aplasia/Hypoplasia of the patella (HP:0006498)	2.28235142
40	Pendular nystagmus (HP:0012043)	2.26403294
41	Genetic anticipation (HP:0003743)	2.25133567
42	Renal cortical cysts (HP:0000803)	2.24223072
43	Abnormality of the pons (HP:0007361)	2.24069700
44	Decreased circulating renin level (HP:0003351)	2.19250121
45	Hypoplasia of the pons (HP:0012110)	2.18445893
46	Optic nerve hypoplasia (HP:0000609)	2.17343126
47	Genital tract atresia (HP:0001827)	2.16412645
48	Vaginal atresia (HP:0000148)	2.14276290
49	Furrowed tongue (HP:0000221)	2.12235917
50	Congenital hepatic fibrosis (HP:0002612)	2.12168175
51	Sclerocornea (HP:0000647)	2.11476528
52	Abnormal biliary tract physiology (HP:0012439)	2.06758529
53	Bile duct proliferation (HP:0001408)	2.06758529
54	Stomach cancer (HP:0012126)	2.06685850
55	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06259170
56	Poor coordination (HP:0002370)	2.03232524
57	Anencephaly (HP:0002323)	2.03183459
58	Pachygyria (HP:0001302)	2.02542526
59	Male pseudohermaphroditism (HP:0000037)	2.01739803
60	Methylmalonic acidemia (HP:0002912)	2.01123028
61	Chorioretinal atrophy (HP:0000533)	2.00731348
62	Polyuria (HP:0000103)	1.99872639
63	Fair hair (HP:0002286)	1.97345680
64	Congenital, generalized hypertrichosis (HP:0004540)	1.96506332
65	Decreased central vision (HP:0007663)	1.95180543
66	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95057786
67	Abnormality of the labia minora (HP:0012880)	1.93315731
68	Drooling (HP:0002307)	1.92602749
69	Severe muscular hypotonia (HP:0006829)	1.90220511
70	Febrile seizures (HP:0002373)	1.89712718
71	Hemiparesis (HP:0001269)	1.88084468
72	Widely spaced teeth (HP:0000687)	1.84485201
73	Increased corneal curvature (HP:0100692)	1.84432185
74	Keratoconus (HP:0000563)	1.84432185
75	Retinal dysplasia (HP:0007973)	1.81978463
76	Bony spicule pigmentary retinopathy (HP:0007737)	1.81559806
77	Postaxial foot polydactyly (HP:0001830)	1.81283840
78	Abnormal rod and cone electroretinograms (HP:0008323)	1.81253188
79	Congenital sensorineural hearing impairment (HP:0008527)	1.80452321
80	Colon cancer (HP:0003003)	1.79962768
81	Dandy-Walker malformation (HP:0001305)	1.79962182
82	Absent/shortened dynein arms (HP:0200106)	1.79685368
83	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79685368
84	Postaxial hand polydactyly (HP:0001162)	1.77584451
85	Dyskinesia (HP:0100660)	1.77392298
86	Short tibia (HP:0005736)	1.76727147
87	Hypothermia (HP:0002045)	1.76267234
88	Abnormal pancreas size (HP:0012094)	1.74539040
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74217524
90	Small hand (HP:0200055)	1.73648076
91	Clumsiness (HP:0002312)	1.73175204
92	Limb dystonia (HP:0002451)	1.72986276
93	Focal motor seizures (HP:0011153)	1.72457339
94	Excessive salivation (HP:0003781)	1.71568459
95	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.71159109
96	Concave nail (HP:0001598)	1.68886626
97	Focal seizures (HP:0007359)	1.68291504
98	Increased CSF lactate (HP:0002490)	1.66102694
99	Intestinal atresia (HP:0011100)	1.64022351
100	Narrow forehead (HP:0000341)	1.63342459

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.44261573
2	BMPR1B	3.43227355
3	WNK3	3.26735747
4	CASK	2.91276471
5	ADRBK2	2.90550185
6	ACVR1B	2.71756275
7	ZAK	2.37884402
8	MAPK13	2.21275445
9	MAP3K4	2.19728356
10	GRK1	2.19515400
11	PINK1	2.05607226
12	INSRR	2.02458804
13	WNK4	2.02426077
14	NUAK1	1.99237728
15	TLK1	1.94264754
16	MAP4K2	1.88915700
17	PNCK	1.78330389
18	MAP2K7	1.77720535
19	MKNK2	1.75032933
20	MARK1	1.69327748
21	TAOK3	1.63324049
22	OXSR1	1.56727466
23	DAPK2	1.52624981
24	TRIM28	1.42878470
25	BRSK2	1.42245098
26	SIK2	1.29224119
27	TNIK	1.27116654
28	ADRBK1	1.22589100
29	STK39	1.21384488
30	CAMKK2	1.17220441
31	PAK3	1.16448526
32	TGFBR1	1.12331610
33	TXK	1.02861242
34	ERBB3	1.01727355
35	BCR	0.99220244
36	MAPK15	0.96972646
37	WEE1	0.95661667
38	DYRK2	0.92446551
39	PRKCG	0.90082393
40	PRKCE	0.87308146
41	PIK3CA	0.86249320
42	AKT3	0.85020957
43	MUSK	0.82796772
44	CSNK1G2	0.80063661
45	MKNK1	0.79089393
46	EPHA4	0.76359625
47	NTRK2	0.75667765
48	STK38L	0.72190705
49	MAP2K4	0.69027689
50	PLK2	0.68212738
51	STK11	0.66637202
52	EPHA3	0.66190140
53	PKN1	0.66119916
54	FGFR2	0.65779760
55	CSNK1G1	0.63771337
56	RPS6KA5	0.63602924
57	CHUK	0.59562530
58	VRK1	0.57344461
59	IRAK1	0.57279147
60	BRD4	0.57174339
61	NTRK3	0.56295186
62	CSNK1A1L	0.55945148
63	TIE1	0.54073691
64	CSNK1G3	0.52785521
65	CAMK2A	0.51356608
66	SGK2	0.50137962
67	TEC	0.49483803
68	OBSCN	0.48438177
69	EIF2AK3	0.47758227
70	IKBKB	0.46559698
71	NEK2	0.46210720
72	BCKDK	0.46087659
73	PRKACA	0.46017115
74	DYRK1A	0.45633041
75	PHKG1	0.45217629
76	PHKG2	0.45217629
77	PRKAA1	0.44699176
78	PRKCQ	0.43480216
79	MAP2K6	0.41434988
80	PTK2B	0.40311511
81	PLK3	0.39817245
82	GRK7	0.38815197
83	ERBB2	0.37451158
84	SGK223	0.36268662
85	SGK494	0.36268662
86	PRKCZ	0.36165273
87	CAMK4	0.35903642
88	FER	0.35812689
89	CSNK1D	0.35188370
90	PLK4	0.34812220
91	CAMK1	0.34801505
92	CSNK1A1	0.34292542
93	MAPKAPK5	0.33666012
94	CDK3	0.32549753
95	PRKAA2	0.31887333
96	NLK	0.29595173
97	FLT3	0.29341882
98	PRKG1	0.29149313
99	CCNB1	0.28428320
100	MINK1	0.27934617

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.84694253
2	Nicotine addiction_Homo sapiens_hsa05033	2.69003219
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.60723375
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.55646233
5	Butanoate metabolism_Homo sapiens_hsa00650	2.50613663
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47419963
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.46503245
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38912364
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.36705200
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24760614
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.19542378
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.11546985
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.08902548
14	Protein export_Homo sapiens_hsa03060	2.00658218
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.90840753
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.87440487
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.81885119
18	Basal transcription factors_Homo sapiens_hsa03022	1.79597513
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.79463940
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.72467117
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.71048630
22	Taste transduction_Homo sapiens_hsa04742	1.61327109
23	Morphine addiction_Homo sapiens_hsa05032	1.56903149
24	Olfactory transduction_Homo sapiens_hsa04740	1.48322813
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.47214722
26	Caffeine metabolism_Homo sapiens_hsa00232	1.43940073
27	Homologous recombination_Homo sapiens_hsa03440	1.42141029
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.38926175
29	Propanoate metabolism_Homo sapiens_hsa00640	1.38365565
30	RNA polymerase_Homo sapiens_hsa03020	1.36225951
31	GABAergic synapse_Homo sapiens_hsa04727	1.30962166
32	Parkinsons disease_Homo sapiens_hsa05012	1.30276584
33	RNA degradation_Homo sapiens_hsa03018	1.26067161
34	Regulation of autophagy_Homo sapiens_hsa04140	1.25614338
35	Circadian entrainment_Homo sapiens_hsa04713	1.25127801
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24308282
37	Peroxisome_Homo sapiens_hsa04146	1.22095847
38	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21825385
39	ABC transporters_Homo sapiens_hsa02010	1.21450944
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.14701999
41	Insulin secretion_Homo sapiens_hsa04911	1.14371831
42	Circadian rhythm_Homo sapiens_hsa04710	1.12357871
43	Serotonergic synapse_Homo sapiens_hsa04726	1.06665520
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04178644
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02396994
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.01272602
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00647532
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99570822
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.94535039
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94159274
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92239159
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.91030853
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87911810
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.86599607
55	Huntingtons disease_Homo sapiens_hsa05016	0.85988527
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84001313
57	Alzheimers disease_Homo sapiens_hsa05010	0.80193844
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79445099
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78642295
60	Retinol metabolism_Homo sapiens_hsa00830	0.77727905
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76950388
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73085038
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.72340019
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71050885
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70785245
66	Cocaine addiction_Homo sapiens_hsa05030	0.70580125
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67955162
68	Salivary secretion_Homo sapiens_hsa04970	0.63288533
69	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.61552982
70	Sulfur relay system_Homo sapiens_hsa04122	0.60234975
71	Amphetamine addiction_Homo sapiens_hsa05031	0.59433940
72	Long-term depression_Homo sapiens_hsa04730	0.55484284
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55305559
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53707605
75	Purine metabolism_Homo sapiens_hsa00230	0.52422785
76	Cholinergic synapse_Homo sapiens_hsa04725	0.51250322
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49018018
78	Mineral absorption_Homo sapiens_hsa04978	0.47437296
79	Histidine metabolism_Homo sapiens_hsa00340	0.47400552
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.47124735
81	Metabolic pathways_Homo sapiens_hsa01100	0.46477232
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.45961206
83	One carbon pool by folate_Homo sapiens_hsa00670	0.44955335
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41289045
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38942731
86	Axon guidance_Homo sapiens_hsa04360	0.37048456
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36165375
88	Gastric acid secretion_Homo sapiens_hsa04971	0.36008013
89	Sulfur metabolism_Homo sapiens_hsa00920	0.35771172
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35684010
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35389209
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35211716
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.34857211
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33983747
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.33712703
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33489295
97	Renin secretion_Homo sapiens_hsa04924	0.32459718
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.32204167
99	Asthma_Homo sapiens_hsa05310	0.31247925
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29783663

ZNF791

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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