ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.60558257
2	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.12814492
3	regulation of translation, ncRNA-mediated (GO:0045974)	4.12814492
4	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.12814492
5	fucose catabolic process (GO:0019317)	3.96337979
6	L-fucose metabolic process (GO:0042354)	3.96337979
7	L-fucose catabolic process (GO:0042355)	3.96337979
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.74879884
9	response to pheromone (GO:0019236)	3.72028877
10	kidney morphogenesis (GO:0060993)	3.58449769
11	regulation of posttranscriptional gene silencing (GO:0060147)	3.57949520
12	regulation of gene silencing by miRNA (GO:0060964)	3.57949520
13	regulation of gene silencing by RNA (GO:0060966)	3.57949520
14	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.36662415
15	indole-containing compound catabolic process (GO:0042436)	3.29992528
16	indolalkylamine catabolic process (GO:0046218)	3.29992528
17	tryptophan catabolic process (GO:0006569)	3.29992528
18	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.29694972
19	indolalkylamine metabolic process (GO:0006586)	3.29512156
20	kynurenine metabolic process (GO:0070189)	3.28860011
21	neural tube formation (GO:0001841)	3.23915151
22	negative regulation of telomere maintenance (GO:0032205)	3.15989759
23	behavioral response to ethanol (GO:0048149)	3.15220663
24	gamma-aminobutyric acid transport (GO:0015812)	3.12453551
25	pyrimidine nucleobase catabolic process (GO:0006208)	2.99092927
26	regulation of telomere maintenance (GO:0032204)	2.98702276
27	nonmotile primary cilium assembly (GO:0035058)	2.97240765
28	epithelial cilium movement (GO:0003351)	2.94066152
29	tryptophan metabolic process (GO:0006568)	2.92886542
30	protein K11-linked deubiquitination (GO:0035871)	2.90108654
31	protein polyglutamylation (GO:0018095)	2.89294901
32	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.88815181
33	neuronal action potential (GO:0019228)	2.84268359
34	somite development (GO:0061053)	2.81487862
35	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.79668661
36	spinal cord motor neuron differentiation (GO:0021522)	2.76589466
37	water-soluble vitamin biosynthetic process (GO:0042364)	2.76523470
38	cornea development in camera-type eye (GO:0061303)	2.76260097
39	presynaptic membrane assembly (GO:0097105)	2.74711380
40	regulation of hippo signaling (GO:0035330)	2.74117439
41	replication fork processing (GO:0031297)	2.72531748
42	sulfation (GO:0051923)	2.70476315
43	atrial cardiac muscle cell action potential (GO:0086014)	2.66923060
44	indole-containing compound metabolic process (GO:0042430)	2.66367778
45	axoneme assembly (GO:0035082)	2.65563688
46	rRNA catabolic process (GO:0016075)	2.65144689
47	piRNA metabolic process (GO:0034587)	2.63607858
48	detection of light stimulus involved in visual perception (GO:0050908)	2.63414376
49	detection of light stimulus involved in sensory perception (GO:0050962)	2.63414376
50	cilium or flagellum-dependent cell motility (GO:0001539)	2.59358530
51	DNA deamination (GO:0045006)	2.58412583
52	regulation of action potential (GO:0098900)	2.57944844
53	reflex (GO:0060004)	2.57119079
54	reciprocal DNA recombination (GO:0035825)	2.57113763
55	reciprocal meiotic recombination (GO:0007131)	2.57113763
56	cilium organization (GO:0044782)	2.55589403
57	recombinational repair (GO:0000725)	2.55504376
58	double-strand break repair via homologous recombination (GO:0000724)	2.54985752
59	primary amino compound metabolic process (GO:1901160)	2.54659321
60	transmission of nerve impulse (GO:0019226)	2.54388826
61	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.53662433
62	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.53299493
63	regulation of mesoderm development (GO:2000380)	2.51941841
64	cilium assembly (GO:0042384)	2.49578346
65	cilium movement (GO:0003341)	2.49531668
66	retinal cone cell development (GO:0046549)	2.49500305
67	serotonin metabolic process (GO:0042428)	2.48768931
68	cellular ketone body metabolic process (GO:0046950)	2.47785971
69	nucleobase catabolic process (GO:0046113)	2.47428919
70	inner ear receptor stereocilium organization (GO:0060122)	2.47258852
71	synaptic transmission, cholinergic (GO:0007271)	2.47092843
72	presynaptic membrane organization (GO:0097090)	2.46998153
73	cilium morphogenesis (GO:0060271)	2.46220877
74	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.46122994
75	meiotic chromosome segregation (GO:0045132)	2.45742581
76	hindbrain development (GO:0030902)	2.45539070
77	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.44605867
78	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.43965386
79	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.43040066
80	NADH dehydrogenase complex assembly (GO:0010257)	2.43040066
81	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.43040066
82	nephron epithelium morphogenesis (GO:0072088)	2.41934394
83	nephron tubule morphogenesis (GO:0072078)	2.41934394
84	head development (GO:0060322)	2.41906191
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.40724980
86	histone H3-K9 methylation (GO:0051567)	2.39608323
87	startle response (GO:0001964)	2.39089102
88	limb development (GO:0060173)	2.38618191
89	appendage development (GO:0048736)	2.38618191
90	cAMP catabolic process (GO:0006198)	2.38003438
91	limb bud formation (GO:0060174)	2.34964517
92	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.33152065
93	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.32556674
94	postsynaptic membrane organization (GO:0001941)	2.31822376
95	neuron cell-cell adhesion (GO:0007158)	2.30931452
96	photoreceptor cell development (GO:0042461)	2.29978978
97	forebrain neuron differentiation (GO:0021879)	2.29891012
98	DNA demethylation (GO:0080111)	2.29026909
99	signal peptide processing (GO:0006465)	2.28388993
100	photoreceptor cell maintenance (GO:0045494)	2.28278721

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* ZNF274_21170338_ChIP-Seq_K562_Hela	3.84868548
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.41395953
3	VDR_22108803_ChIP-Seq_LS180_Human	3.20489396
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.10381481
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.07026142
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.66419858
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.53849229
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36668208
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33911304
10	FUS_26573619_Chip-Seq_HEK293_Human	2.32077980
11	EWS_26573619_Chip-Seq_HEK293_Human	2.32007917
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29950564
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28165369
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14492495
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06481429
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.05948237
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.00762010
18	* P300_19829295_ChIP-Seq_ESCs_Human	1.98148731
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.97865305
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91481399
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.91310830
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90182919
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.84335687
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.81461482
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.79850829
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79850829
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.77401350
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.71349352
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70203787
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66767342
31	STAT3_23295773_ChIP-Seq_U87_Human	1.66558156
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64568368
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.63364549
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62461489
35	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.59650443
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56364619
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56187754
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55397028
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.54350500
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.51920389
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50407579
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50163152
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49711364
44	TCF4_23295773_ChIP-Seq_U87_Human	1.49569164
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48894123
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46410476
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.45955598
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.44785333
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44436905
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.43760092
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.40481156
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40481156
53	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.39569186
54	AR_25329375_ChIP-Seq_VCAP_Human	1.38079451
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.37149583
56	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35585438
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35280086
58	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32481087
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29629296
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29584580
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29518622
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23557762
63	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.19219037
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.19133719
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19055298
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16099051
67	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.15925042
68	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.15576510
69	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.15502118
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14399465
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14395701
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13560487
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13560487
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12335415
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06879387
76	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05776308
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05776308
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05265863
79	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05009015
80	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04212854
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00216532
82	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.99837021
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99491920
84	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99183570
85	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98821913
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98536458
87	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.97763520
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97756803
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97680888
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96391957
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95926000
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95756894
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94729079
94	DROSHA_22980978_ChIP-Seq_HELA_Human	0.94233362
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92924230
96	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.92671137
97	ELK1_19687146_ChIP-ChIP_HELA_Human	0.92596690
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92355198
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92243619
100	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.92128549

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.12892328
2	MP0000569_abnormal_digit_pigmentation	2.86310301
3	MP0006292_abnormal_olfactory_placode	2.61646619
4	MP0003136_yellow_coat_color	2.44602902
5	MP0002102_abnormal_ear_morphology	2.38372655
6	MP0002638_abnormal_pupillary_reflex	2.25207152
7	MP0003787_abnormal_imprinting	2.21542628
8	MP0005551_abnormal_eye_electrophysiolog	2.15140152
9	MP0009046_muscle_twitch	2.04031459
10	MP0003195_calcinosis	1.99371712
11	MP0001968_abnormal_touch/_nociception	1.94605778
12	MP0004133_heterotaxia	1.90800097
13	MP0006072_abnormal_retinal_apoptosis	1.88390930
14	MP0003646_muscle_fatigue	1.87897083
15	MP0000631_abnormal_neuroendocrine_gland	1.85730224
16	MP0005645_abnormal_hypothalamus_physiol	1.85120312
17	MP0009745_abnormal_behavioral_response	1.82733126
18	MP0003890_abnormal_embryonic-extraembry	1.82237356
19	MP0003880_abnormal_central_pattern	1.78978963
20	MP0002938_white_spotting	1.78853242
21	MP0004142_abnormal_muscle_tone	1.74994961
22	MP0005646_abnormal_pituitary_gland	1.72025778
23	MP0008057_abnormal_DNA_replication	1.68001369
24	MP0001486_abnormal_startle_reflex	1.65686945
25	MP0002837_dystrophic_cardiac_calcinosis	1.64322215
26	MP0000778_abnormal_nervous_system	1.62904196
27	MP0001485_abnormal_pinna_reflex	1.59435871
28	MP0001986_abnormal_taste_sensitivity	1.58272336
29	MP0008872_abnormal_physiological_respon	1.57032968
30	MP0002736_abnormal_nociception_after	1.54006812
31	MP0006276_abnormal_autonomic_nervous	1.53569796
32	MP0004043_abnormal_pH_regulation	1.53116470
33	MP0005253_abnormal_eye_physiology	1.52903041
34	MP0002272_abnormal_nervous_system	1.49161234
35	MP0004147_increased_porphyrin_level	1.48290152
36	MP0004885_abnormal_endolymph	1.46534695
37	MP0000427_abnormal_hair_cycle	1.45754454
38	MP0002928_abnormal_bile_duct	1.42677659
39	MP0001293_anophthalmia	1.41185836
40	MP0005174_abnormal_tail_pigmentation	1.39742391
41	MP0002653_abnormal_ependyma_morphology	1.36875524
42	MP0001501_abnormal_sleep_pattern	1.36216313
43	MP0002735_abnormal_chemical_nociception	1.34514585
44	MP0002064_seizures	1.34094742
45	MP0003119_abnormal_digestive_system	1.30605514
46	MP0002557_abnormal_social/conspecific_i	1.26600780
47	MP0002572_abnormal_emotion/affect_behav	1.25288376
48	MP0004742_abnormal_vestibular_system	1.23702798
49	MP0003635_abnormal_synaptic_transmissio	1.21561766
50	MP0003937_abnormal_limbs/digits/tail_de	1.20799654
51	MP0002160_abnormal_reproductive_system	1.20729537
52	MP0002876_abnormal_thyroid_physiology	1.20627228
53	MP0008058_abnormal_DNA_repair	1.19756638
54	MP0008995_early_reproductive_senescence	1.19361011
55	MP0003121_genomic_imprinting	1.17054417
56	MP0000383_abnormal_hair_follicle	1.16396198
57	MP0000372_irregular_coat_pigmentation	1.14885827
58	MP0004145_abnormal_muscle_electrophysio	1.13514819
59	MP0001984_abnormal_olfaction	1.11559383
60	MP0002751_abnormal_autonomic_nervous	1.11383381
61	MP0004924_abnormal_behavior	1.11191473
62	MP0005386_behavior/neurological_phenoty	1.11191473
63	MP0002063_abnormal_learning/memory/cond	1.10145796
64	MP0001970_abnormal_pain_threshold	1.09308882
65	MP0005195_abnormal_posterior_eye	1.08717100
66	MP0002067_abnormal_sensory_capabilities	1.07041379
67	MP0002733_abnormal_thermal_nociception	1.06503177
68	MP0003122_maternal_imprinting	1.04376355
69	MP0002234_abnormal_pharynx_morphology	1.03968140
70	MP0008961_abnormal_basal_metabolism	1.02992328
71	MP0002752_abnormal_somatic_nervous	1.01635527
72	MP0005084_abnormal_gallbladder_morpholo	1.01324100
73	MP0002734_abnormal_mechanical_nocicepti	1.00989179
74	MP0002184_abnormal_innervation	1.00511203
75	MP0001188_hyperpigmentation	0.98776284
76	MP0003283_abnormal_digestive_organ	0.98532769
77	MP0000955_abnormal_spinal_cord	0.97909429
78	MP0003567_abnormal_fetal_cardiomyocyte	0.92781224
79	MP0005389_reproductive_system_phenotype	0.92382104
80	MP0002095_abnormal_skin_pigmentation	0.92173766
81	MP0001529_abnormal_vocalization	0.91998244
82	MP0005391_vision/eye_phenotype	0.90815752
83	MP0003011_delayed_dark_adaptation	0.90627442
84	MP0001286_abnormal_eye_development	0.89962252
85	MP0001324_abnormal_eye_pigmentation	0.89546561
86	MP0003698_abnormal_male_reproductive	0.88985561
87	MP0001502_abnormal_circadian_rhythm	0.87227821
88	MP0003718_maternal_effect	0.86483956
89	MP0002882_abnormal_neuron_morphology	0.85876427
90	MP0000049_abnormal_middle_ear	0.85704291
91	MP0003137_abnormal_impulse_conducting	0.84076743
92	MP0003861_abnormal_nervous_system	0.83478036
93	MP0000026_abnormal_inner_ear	0.82320569
94	MP0002210_abnormal_sex_determination	0.81984502
95	MP0005423_abnormal_somatic_nervous	0.81559367
96	MP0003878_abnormal_ear_physiology	0.78289728
97	MP0005377_hearing/vestibular/ear_phenot	0.78289728
98	MP0002152_abnormal_brain_morphology	0.77955519
99	MP0001929_abnormal_gametogenesis	0.76855265
100	MP0001963_abnormal_hearing_physiology	0.75077152

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.22411574
2	Molar tooth sign on MRI (HP:0002419)	3.78703227
3	Abnormality of midbrain morphology (HP:0002418)	3.78703227
4	Pancreatic fibrosis (HP:0100732)	3.77154323
5	Hyperventilation (HP:0002883)	3.63983363
6	True hermaphroditism (HP:0010459)	3.60894525
7	Nephronophthisis (HP:0000090)	3.60377110
8	Type II lissencephaly (HP:0007260)	3.37447971
9	Congenital stationary night blindness (HP:0007642)	3.30001352
10	Genetic anticipation (HP:0003743)	3.12698790
11	Abnormality of the renal medulla (HP:0100957)	3.11075672
12	Progressive cerebellar ataxia (HP:0002073)	2.94165830
13	Abnormality of the renal cortex (HP:0011035)	2.80743515
14	Lissencephaly (HP:0001339)	2.78747548
15	Birth length less than 3rd percentile (HP:0003561)	2.78263560
16	Medial flaring of the eyebrow (HP:0010747)	2.69157429
17	Gaze-evoked nystagmus (HP:0000640)	2.68576004
18	Protruding tongue (HP:0010808)	2.67409238
19	Chronic hepatic failure (HP:0100626)	2.61649188
20	Cystic liver disease (HP:0006706)	2.61264566
21	Pendular nystagmus (HP:0012043)	2.58965656
22	Patellar aplasia (HP:0006443)	2.55590481
23	Inability to walk (HP:0002540)	2.52720130
24	Tubular atrophy (HP:0000092)	2.49391261
25	Cerebellar dysplasia (HP:0007033)	2.48559907
26	Broad-based gait (HP:0002136)	2.46340113
27	Progressive inability to walk (HP:0002505)	2.42278419
28	Abnormality of the pons (HP:0007361)	2.41364648
29	Aplasia/Hypoplasia of the patella (HP:0006498)	2.40124469
30	Attenuation of retinal blood vessels (HP:0007843)	2.37348557
31	Bilateral microphthalmos (HP:0007633)	2.36637749
32	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.36045477
33	Abnormality of alanine metabolism (HP:0010916)	2.36045477
34	Hyperalaninemia (HP:0003348)	2.36045477
35	Hypoplasia of the pons (HP:0012110)	2.34730608
36	Abolished electroretinogram (ERG) (HP:0000550)	2.34364573
37	Anencephaly (HP:0002323)	2.26473178
38	Gait imbalance (HP:0002141)	2.23665956
39	Sclerocornea (HP:0000647)	2.20258394
40	Optic nerve hypoplasia (HP:0000609)	2.20188873
41	Abnormality of the labia minora (HP:0012880)	2.17950064
42	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.15255868
43	Abnormal drinking behavior (HP:0030082)	2.15033785
44	Polydipsia (HP:0001959)	2.15033785
45	Febrile seizures (HP:0002373)	2.13502425
46	Large for gestational age (HP:0001520)	2.12155028
47	Congenital primary aphakia (HP:0007707)	2.10938785
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10605302
49	Absent/shortened dynein arms (HP:0200106)	2.10605302
50	Nephrogenic diabetes insipidus (HP:0009806)	2.04822486
51	Colon cancer (HP:0003003)	2.04415988
52	Genital tract atresia (HP:0001827)	2.04215088
53	Vaginal atresia (HP:0000148)	2.01904581
54	Chorioretinal atrophy (HP:0000533)	2.00574853
55	Pachygyria (HP:0001302)	1.98722244
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98559671
57	Oligodactyly (hands) (HP:0001180)	1.98165669
58	Stomach cancer (HP:0012126)	1.96898327
59	Keratoconus (HP:0000563)	1.96436245
60	Increased corneal curvature (HP:0100692)	1.96436245
61	Congenital hepatic fibrosis (HP:0002612)	1.96271964
62	Bile duct proliferation (HP:0001408)	1.95554522
63	Abnormal biliary tract physiology (HP:0012439)	1.95554522
64	Furrowed tongue (HP:0000221)	1.95264676
65	Small hand (HP:0200055)	1.95110450
66	Intestinal atresia (HP:0011100)	1.93786057
67	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.93404001
68	Decreased circulating renin level (HP:0003351)	1.91649536
69	Concave nail (HP:0001598)	1.91095717
70	Fair hair (HP:0002286)	1.90943481
71	Drooling (HP:0002307)	1.90204149
72	Poor coordination (HP:0002370)	1.89970658
73	Partial agenesis of the corpus callosum (HP:0001338)	1.89761276
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.88686402
75	Dandy-Walker malformation (HP:0001305)	1.87771350
76	Clumsiness (HP:0002312)	1.87727448
77	Focal seizures (HP:0007359)	1.81480674
78	Congenital, generalized hypertrichosis (HP:0004540)	1.80288923
79	Hemiparesis (HP:0001269)	1.75069326
80	Focal motor seizures (HP:0011153)	1.74851989
81	Male pseudohermaphroditism (HP:0000037)	1.74450796
82	Ectopic kidney (HP:0000086)	1.74388095
83	Abnormality of the renal collecting system (HP:0004742)	1.73880312
84	Duplicated collecting system (HP:0000081)	1.73818952
85	Renal cortical cysts (HP:0000803)	1.73724708
86	Bony spicule pigmentary retinopathy (HP:0007737)	1.71654242
87	Widely spaced teeth (HP:0000687)	1.70083755
88	Volvulus (HP:0002580)	1.70048271
89	Supernumerary spleens (HP:0009799)	1.69952257
90	Dialeptic seizures (HP:0011146)	1.69591332
91	Postaxial foot polydactyly (HP:0001830)	1.69344288
92	Abnormal respiratory epithelium morphology (HP:0012253)	1.68393558
93	Abnormal respiratory motile cilium morphology (HP:0005938)	1.68393558
94	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.68063828
95	Abnormality of the ileum (HP:0001549)	1.67551673
96	Excessive salivation (HP:0003781)	1.67549608
97	Preaxial hand polydactyly (HP:0001177)	1.67294843
98	Anophthalmia (HP:0000528)	1.67097663
99	Abnormal rod and cone electroretinograms (HP:0008323)	1.66830319
100	Severe muscular hypotonia (HP:0006829)	1.65839296

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.50992826
2	BMPR1B	3.27864441
3	ACVR1B	2.91934514
4	ZAK	2.80224920
5	ADRBK2	2.78460386
6	WNK3	2.50876392
7	PNCK	2.37907508
8	NUAK1	2.19307276
9	CASK	2.18810410
10	MKNK2	2.04837256
11	TLK1	1.98420384
12	GRK1	1.95877941
13	INSRR	1.92501567
14	MAPK13	1.82697866
15	MAP4K2	1.82542904
16	TNIK	1.81241566
17	PINK1	1.78241847
18	MAP3K4	1.74736022
19	MARK1	1.69102619
20	WNK4	1.64839270
21	TAOK3	1.59449194
22	DAPK2	1.50015322
23	DYRK2	1.42858423
24	TGFBR1	1.32235018
25	CAMK1G	1.25223441
26	FGFR2	1.24106114
27	OXSR1	1.23748881
28	MAPK15	1.22536309
29	MKNK1	1.20730418
30	VRK1	1.15600931
31	ADRBK1	1.10286450
32	BRSK2	1.07435710
33	CAMKK2	1.05312346
34	PAK3	1.02494467
35	CAMK1D	1.00264853
36	WEE1	0.95760430
37	NTRK3	0.90086093
38	PRKCG	0.88517915
39	STK38L	0.84904098
40	IRAK1	0.84529476
41	SIK2	0.83724588
42	STK39	0.82338680
43	PLK4	0.80838254
44	TRIM28	0.77536984
45	NTRK2	0.75935411
46	NEK2	0.74643605
47	BRD4	0.73577064
48	NLK	0.73020955
49	CHEK2	0.71954600
50	STK11	0.71699990
51	PRKCE	0.71565549
52	STK3	0.71226568
53	PLK3	0.69955882
54	MAP2K7	0.69343072
55	CAMK1	0.67115273
56	EPHA4	0.66123277
57	CSNK1G2	0.65277056
58	NME1	0.63485229
59	CSNK1G1	0.62120695
60	MAP2K6	0.61682220
61	ATR	0.60846320
62	LATS1	0.60261525
63	TAF1	0.60203930
64	PIK3CA	0.59335142
65	AKT3	0.58222834
66	DYRK1A	0.57280520
67	SGK2	0.57028088
68	CDC7	0.56769908
69	RPS6KA5	0.56769323
70	MUSK	0.56725538
71	TXK	0.56225309
72	PKN1	0.55144355
73	TIE1	0.54433561
74	MAPKAPK5	0.54230123
75	PRKAA1	0.52942526
76	EPHA3	0.52335119
77	PLK2	0.50630062
78	CDK3	0.49470541
79	TYRO3	0.47499580
80	WNK1	0.47433841
81	MAP2K4	0.47388673
82	PLK1	0.47245539
83	PASK	0.47021514
84	TEC	0.46708701
85	CSNK1D	0.46563362
86	CSNK1A1L	0.46536523
87	ATM	0.44461712
88	BCR	0.44437721
89	CAMK4	0.43615357
90	CSNK1G3	0.43452528
91	PTK2B	0.41540998
92	ERBB2	0.40658201
93	CAMK2A	0.39039203
94	FLT3	0.38033574
95	PHKG1	0.37879967
96	PHKG2	0.37879967
97	SGK494	0.37797263
98	SGK223	0.37797263
99	CSNK1A1	0.37705026
100	SRPK1	0.37384577

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.95704424
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.72538014
3	Nicotine addiction_Homo sapiens_hsa05033	2.68132136
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.37296724
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.27983775
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.21803052
7	Homologous recombination_Homo sapiens_hsa03440	2.21555357
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.18293698
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.15605785
10	RNA polymerase_Homo sapiens_hsa03020	2.14126264
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.13789225
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.09314251
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.01223940
14	Butanoate metabolism_Homo sapiens_hsa00650	2.00525656
15	Basal transcription factors_Homo sapiens_hsa03022	1.89570906
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81916309
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.78112454
18	Taste transduction_Homo sapiens_hsa04742	1.77837572
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77310989
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.73687893
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71614266
22	Morphine addiction_Homo sapiens_hsa05032	1.60214990
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.58124089
24	RNA degradation_Homo sapiens_hsa03018	1.50857035
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.48395678
26	Olfactory transduction_Homo sapiens_hsa04740	1.47200236
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.42319396
28	Protein export_Homo sapiens_hsa03060	1.41168135
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.32118633
30	Circadian entrainment_Homo sapiens_hsa04713	1.31337546
31	One carbon pool by folate_Homo sapiens_hsa00670	1.25199537
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21830046
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.20384373
34	Insulin secretion_Homo sapiens_hsa04911	1.19702682
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19498079
36	Parkinsons disease_Homo sapiens_hsa05012	1.16807541
37	Serotonergic synapse_Homo sapiens_hsa04726	1.15502101
38	GABAergic synapse_Homo sapiens_hsa04727	1.12760495
39	ABC transporters_Homo sapiens_hsa02010	1.11610851
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.08694071
41	Propanoate metabolism_Homo sapiens_hsa00640	1.08536046
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07390787
43	Basal cell carcinoma_Homo sapiens_hsa05217	1.04058187
44	Caffeine metabolism_Homo sapiens_hsa00232	1.02341937
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02134824
46	Huntingtons disease_Homo sapiens_hsa05016	1.01484253
47	Lysine degradation_Homo sapiens_hsa00310	1.00375221
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.95308528
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93017648
50	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.87981047
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.87033178
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86267114
53	Circadian rhythm_Homo sapiens_hsa04710	0.86227721
54	Long-term depression_Homo sapiens_hsa04730	0.84911528
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.84185612
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83536141
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.82956940
58	Cocaine addiction_Homo sapiens_hsa05030	0.81557969
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81091305
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78297100
61	Regulation of autophagy_Homo sapiens_hsa04140	0.76882401
62	Cholinergic synapse_Homo sapiens_hsa04725	0.75246960
63	Purine metabolism_Homo sapiens_hsa00230	0.70058239
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69175854
65	RNA transport_Homo sapiens_hsa03013	0.68411637
66	Alzheimers disease_Homo sapiens_hsa05010	0.67174565
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63734619
68	Salivary secretion_Homo sapiens_hsa04970	0.61484598
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61363593
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.60289066
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.59458873
72	Peroxisome_Homo sapiens_hsa04146	0.58421795
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58282262
74	Amphetamine addiction_Homo sapiens_hsa05031	0.57479965
75	Retinol metabolism_Homo sapiens_hsa00830	0.57195559
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56727409
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56525408
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.56469603
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56183017
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54311110
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52712876
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52334693
83	Alcoholism_Homo sapiens_hsa05034	0.51666781
84	Axon guidance_Homo sapiens_hsa04360	0.50818495
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.50444081
86	Histidine metabolism_Homo sapiens_hsa00340	0.45289649
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44399557
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43911223
89	Gastric acid secretion_Homo sapiens_hsa04971	0.42435213
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.42393483
91	Type II diabetes mellitus_Homo sapiens_hsa04930	0.39285779
92	Ribosome_Homo sapiens_hsa03010	0.38678267
93	Metabolic pathways_Homo sapiens_hsa01100	0.38112182
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38051865
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.38019709
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.37416721
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.35139330
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34217107
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32843334
100	Base excision repair_Homo sapiens_hsa03410	0.31692278

ZNF8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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