ZNF800

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.53701630
2regulation of B cell receptor signaling pathway (GO:0050855)4.85830842
3positive regulation of granulocyte differentiation (GO:0030854)4.66863659
4negative T cell selection (GO:0043383)4.25838147
5negative thymic T cell selection (GO:0045060)4.16415976
6negative regulation of cell killing (GO:0031342)4.08219782
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08219782
8regulation of gamma-delta T cell activation (GO:0046643)4.07830515
9B cell receptor signaling pathway (GO:0050853)4.06643928
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04424249
11regulation of gamma-delta T cell differentiation (GO:0045586)4.01783425
12T cell migration (GO:0072678)4.01021027
13negative regulation of T cell mediated immunity (GO:0002710)3.95910059
14cellular extravasation (GO:0045123)3.89810078
15positive regulation of B cell differentiation (GO:0045579)3.79573316
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.76326676
17positive T cell selection (GO:0043368)3.63474274
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.61400540
19positive regulation of alpha-beta T cell proliferation (GO:0046641)3.57541332
20response to muramyl dipeptide (GO:0032495)3.54845969
21phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.53210401
22regulation of alpha-beta T cell proliferation (GO:0046640)3.51276503
23response to peptidoglycan (GO:0032494)3.49706351
24hepatocyte apoptotic process (GO:0097284)3.47761267
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.42699211
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41774026
27regulation of B cell differentiation (GO:0045577)3.39083140
28antigen processing and presentation of endogenous antigen (GO:0019883)3.36223052
29neutrophil mediated immunity (GO:0002446)3.33626998
30regulation of granulocyte differentiation (GO:0030852)3.33427126
31regulation of interferon-beta biosynthetic process (GO:0045357)3.32169832
32CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.23442859
33T-helper cell differentiation (GO:0042093)3.23442859
34macrophage activation involved in immune response (GO:0002281)3.23182218
35T cell selection (GO:0045058)3.21417017
36detection of other organism (GO:0098543)3.20388110
37positive thymic T cell selection (GO:0045059)3.18339104
38definitive hemopoiesis (GO:0060216)3.16729952
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16050947
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.16050947
41modulation by symbiont of host immune response (GO:0052553)3.16050947
42positive regulation by symbiont of host defense response (GO:0052509)3.16050947
43modulation by symbiont of host defense response (GO:0052031)3.16050947
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16050947
45G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.13258787
46detection of bacterium (GO:0016045)3.07540545
47interferon-gamma production (GO:0032609)3.07374485
48dosage compensation (GO:0007549)3.06954487
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06283386
50B cell homeostasis (GO:0001782)3.05842569
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.02495076
52negative regulation of T-helper cell differentiation (GO:0045623)3.01687080
53negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.01687080
54NIK/NF-kappaB signaling (GO:0038061)2.94750722
55myeloid leukocyte mediated immunity (GO:0002444)2.94616551
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94603746
57CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.93181963
58histone H3-K36 demethylation (GO:0070544)2.92243279
59monoubiquitinated protein deubiquitination (GO:0035520)2.92036917
60histone H3-K4 trimethylation (GO:0080182)2.91581688
61negative regulation of erythrocyte differentiation (GO:0045647)2.89097849
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88983862
63tolerance induction (GO:0002507)2.88973837
64cellular response to ethanol (GO:0071361)2.88186193
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87690142
66positive regulation of interferon-beta production (GO:0032728)2.84730325
67B cell proliferation (GO:0042100)2.83652761
68alpha-beta T cell activation (GO:0046631)2.82699844
69positive regulation of interleukin-2 production (GO:0032743)2.82635906
70microglial cell activation (GO:0001774)2.81434753
71protein K11-linked deubiquitination (GO:0035871)2.81390673
72T cell homeostasis (GO:0043029)2.81361085
73regulation of germinal center formation (GO:0002634)2.80954927
74negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.79672083
75mature B cell differentiation (GO:0002335)2.77230612
76mast cell activation (GO:0045576)2.74385929
77T cell differentiation involved in immune response (GO:0002292)2.73347947
78alpha-beta T cell differentiation involved in immune response (GO:0002293)2.73347947
79alpha-beta T cell activation involved in immune response (GO:0002287)2.73347947
80myeloid cell activation involved in immune response (GO:0002275)2.73008740
81alpha-beta T cell differentiation (GO:0046632)2.72577402
82positive regulation of B cell activation (GO:0050871)2.72278295
83leukocyte aggregation (GO:0070486)2.71727226
84antigen receptor-mediated signaling pathway (GO:0050851)2.70970141
85positive regulation of natural killer cell differentiation (GO:0032825)2.70800793
86nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.70691772
87thymic T cell selection (GO:0045061)2.69812179
88T cell proliferation (GO:0042098)2.67060547
89positive regulation of interferon-alpha production (GO:0032727)2.66222543
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66218251
91response to host immune response (GO:0052572)2.66218251
92negative regulation of adaptive immune response (GO:0002820)2.64964600
93neutrophil activation involved in immune response (GO:0002283)2.64264545
94regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.63568467
95positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.63019073
96response to interleukin-15 (GO:0070672)2.61786260
97detection of external biotic stimulus (GO:0098581)2.60903940
98positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.60525533
99regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.60525533
100regulation of B cell proliferation (GO:0030888)2.60033329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.42247551
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.05522166
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.14354929
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.64980480
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.07459711
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.06097422
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.04255671
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95458605
9RUNX_20019798_ChIP-Seq_JUKART_Human2.82030761
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80096181
11MYB_26560356_Chip-Seq_TH2_Human2.74935524
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59410050
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.50684397
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44074467
15SCL_19346495_ChIP-Seq_HPC-7_Human2.38640713
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37057630
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33083626
18MYB_26560356_Chip-Seq_TH1_Human2.28641003
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.26675086
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25116938
21GATA1_22025678_ChIP-Seq_K562_Human2.23407258
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08996411
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99072652
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96899343
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96086524
26* SPI1_23547873_ChIP-Seq_NB4_Human1.96083681
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.95281823
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82404725
29GATA3_27048872_Chip-Seq_THYMUS_Human1.81000661
30IGF1R_20145208_ChIP-Seq_DFB_Human1.77250516
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75171257
32MAF_26560356_Chip-Seq_TH1_Human1.69268914
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68452434
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67085355
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66215034
36GATA3_26560356_Chip-Seq_TH2_Human1.66182716
37VDR_24787735_ChIP-Seq_THP-1_Human1.64377994
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63802983
39RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.62862528
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61131566
41CIITA_25753668_ChIP-Seq_RAJI_Human1.55334435
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.47762303
43SPI1_23127762_ChIP-Seq_K562_Human1.42731670
44VDR_24763502_ChIP-Seq_THP-1_Human1.41280440
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40430911
46VDR_23849224_ChIP-Seq_CD4+_Human1.38137817
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35483247
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34172699
49ELK1_19687146_ChIP-ChIP_HELA_Human1.31268178
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29213324
51UTX_26944678_Chip-Seq_JUKART_Human1.28702174
52PU_27001747_Chip-Seq_BMDM_Mouse1.27256647
53MYC_22102868_ChIP-Seq_BL_Human1.24402294
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23397715
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.17789290
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17764440
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17585470
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15122393
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13518717
60FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11667292
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07474285
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06299174
63MAF_26560356_Chip-Seq_TH2_Human1.05762843
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05300510
65TFEB_21752829_ChIP-Seq_HELA_Human1.03650097
66ER_23166858_ChIP-Seq_MCF-7_Human1.03636372
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01261479
68GATA2_19941826_ChIP-Seq_K562_Human1.00723295
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00049903
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97643561
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97091779
72GATA2_21666600_ChIP-Seq_HMVEC_Human0.94747358
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94532263
74TAF15_26573619_Chip-Seq_HEK293_Human0.93595059
75SMRT_27268052_Chip-Seq_Bcells_Human0.93112343
76PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92835944
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.91517438
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91407480
79GATA1_19941826_ChIP-Seq_K562_Human0.91103229
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89580790
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89028322
82VDR_21846776_ChIP-Seq_THP-1_Human0.88843143
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86965204
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.86853562
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86727134
86RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86378744
87GATA3_26560356_Chip-Seq_TH1_Human0.86148624
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85223230
89SALL4_22934838_ChIP-ChIP_CD34+_Human0.84957721
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84899077
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84899077
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83865704
93TCF7_22412390_ChIP-Seq_EML_Mouse0.83551521
94E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82432294
95* BRD4_25478319_ChIP-Seq_HGPS_Human0.82404190
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.81320998
97EWS_26573619_Chip-Seq_HEK293_Human0.79918732
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79794601
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.78861591
100FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75314808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.70820876
2MP0003763_abnormal_thymus_physiology3.47542784
3MP0008057_abnormal_DNA_replication3.36129449
4MP0001835_abnormal_antigen_presentation3.20552516
5MP0001800_abnormal_humoral_immune2.75326315
6MP0002166_altered_tumor_susceptibility2.73365488
7MP0005671_abnormal_response_to2.63908694
8MP0000569_abnormal_digit_pigmentation2.62939086
9MP0003436_decreased_susceptibility_to2.49857285
10MP0003300_gastrointestinal_ulcer2.45412948
11MP0005000_abnormal_immune_tolerance2.42369794
12MP0000685_abnormal_immune_system2.41552898
13MP0005387_immune_system_phenotype2.28551599
14MP0001790_abnormal_immune_system2.28551599
15MP0002723_abnormal_immune_serum2.27255711
16MP0002452_abnormal_antigen_presenting2.26524411
17MP0003724_increased_susceptibility_to2.20512523
18MP0002420_abnormal_adaptive_immunity2.20383757
19MP0001819_abnormal_immune_cell2.16656787
20MP0002396_abnormal_hematopoietic_system2.11670928
21MP0002006_tumorigenesis2.09360591
22MP0002398_abnormal_bone_marrow2.06637825
23MP0002419_abnormal_innate_immunity2.03605350
24MP0003303_peritoneal_inflammation2.03217981
25MP0009785_altered_susceptibility_to2.02532725
26MP0003656_abnormal_erythrocyte_physiolo1.96842437
27MP0002405_respiratory_system_inflammati1.93300565
28MP0006082_CNS_inflammation1.93176114
29MP0005025_abnormal_response_to1.90428144
30MP0002138_abnormal_hepatobiliary_system1.82418374
31MP0000716_abnormal_immune_system1.82250971
32MP0000689_abnormal_spleen_morphology1.80706990
33MP0009333_abnormal_splenocyte_physiolog1.74831406
34MP0001545_abnormal_hematopoietic_system1.70565891
35MP0005397_hematopoietic_system_phenotyp1.70565891
36MP0000703_abnormal_thymus_morphology1.70398878
37MP0001873_stomach_inflammation1.67738391
38MP0003828_pulmonary_edema1.66912553
39MP0004947_skin_inflammation1.66007318
40MP0002722_abnormal_immune_system1.65716120
41MP0004808_abnormal_hematopoietic_stem1.62764008
42MP0000465_gastrointestinal_hemorrhage1.60942042
43MP0005310_abnormal_salivary_gland1.60596327
44MP0001853_heart_inflammation1.56840192
45MP0002148_abnormal_hypersensitivity_rea1.52793386
46MP0002429_abnormal_blood_cell1.45913694
47MP0001845_abnormal_inflammatory_respons1.45703500
48MP0001851_eye_inflammation1.45120930
49MP0010155_abnormal_intestine_physiology1.44656998
50MP0005464_abnormal_platelet_physiology1.42074299
51MP0003191_abnormal_cellular_cholesterol1.38635347
52MP0005075_abnormal_melanosome_morpholog1.33286007
53MP0004381_abnormal_hair_follicle1.27923388
54MP0003221_abnormal_cardiomyocyte_apopto1.13838494
55MP0000015_abnormal_ear_pigmentation1.11680898
56MP0009278_abnormal_bone_marrow1.10846764
57MP0010352_gastrointestinal_tract_polyps1.10828275
58MP0004883_abnormal_blood_vessel1.08537667
59MP0008995_early_reproductive_senescence1.08360899
60MP0003866_abnormal_defecation1.07069580
61MP0008961_abnormal_basal_metabolism1.06837244
62MP0009764_decreased_sensitivity_to1.05183483
63MP0003950_abnormal_plasma_membrane1.03843830
64MP0008469_abnormal_protein_level1.02330438
65MP0002095_abnormal_skin_pigmentation0.93207471
66MP0003252_abnormal_bile_duct0.93039808
67MP0002163_abnormal_gland_morphology0.92601742
68MP0003091_abnormal_cell_migration0.91773280
69MP0005164_abnormal_response_to0.91636175
70MP0003786_premature_aging0.90765485
71MP0005379_endocrine/exocrine_gland_phen0.89204001
72MP0003172_abnormal_lysosome_physiology0.88122023
73MP0002928_abnormal_bile_duct0.88054360
74MP0002019_abnormal_tumor_incidence0.87449511
75MP0009115_abnormal_fat_cell0.86131456
76MP0002332_abnormal_exercise_endurance0.86039458
77MP0010234_abnormal_vibrissa_follicle0.80562484
78MP0000858_altered_metastatic_potential0.80189439
79MP0001533_abnormal_skeleton_physiology0.78693770
80MP0009763_increased_sensitivity_to0.76855135
81MP0002132_abnormal_respiratory_system0.76788407
82MP0003045_fibrosis0.75999590
83MP0005174_abnormal_tail_pigmentation0.73786892
84MP0002998_abnormal_bone_remodeling0.71653438
85MP0008004_abnormal_stomach_pH0.70830768
86MP0008260_abnormal_autophagy0.69687062
87MP0001191_abnormal_skin_condition0.69605387
88MP0009765_abnormal_xenobiotic_induced0.68962118
89MP0005376_homeostasis/metabolism_phenot0.67298703
90MP0005451_abnormal_body_composition0.66779778
91MP0005220_abnormal_exocrine_pancreas0.66389315
92MP0008877_abnormal_DNA_methylation0.65383449
93MP0000609_abnormal_liver_physiology0.65353214
94MP0005266_abnormal_metabolism0.64764631
95MP0004484_altered_response_of0.62894908
96MP0000427_abnormal_hair_cycle0.62692066
97MP0002693_abnormal_pancreas_physiology0.62440662
98MP0000372_irregular_coat_pigmentation0.62197910
99MP0005621_abnormal_cell_physiology0.62065932
100MP0001919_abnormal_reproductive_system0.61797201

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.10097439
2Eczematoid dermatitis (HP:0000976)3.96931750
3Recurrent viral infections (HP:0004429)3.93203014
4Abnormality of T cell number (HP:0011839)3.91580791
5Panhypogammaglobulinemia (HP:0003139)3.89329402
6Recurrent fungal infections (HP:0002841)3.76768905
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.76047925
8Recurrent bacterial skin infections (HP:0005406)3.64572029
9Agammaglobulinemia (HP:0004432)3.59268906
10Autoimmune hemolytic anemia (HP:0001890)3.58790572
11Recurrent cutaneous fungal infections (HP:0011370)3.50907775
12Chronic mucocutaneous candidiasis (HP:0002728)3.50907775
13Stomatitis (HP:0010280)3.49586389
14Mediastinal lymphadenopathy (HP:0100721)3.38747192
15Severe combined immunodeficiency (HP:0004430)3.31871887
16Abnormality of B cell number (HP:0010975)3.28457863
17Abnormality of T cells (HP:0002843)3.24838230
18B lymphocytopenia (HP:0010976)3.17399391
19Elevated erythrocyte sedimentation rate (HP:0003565)3.14463161
20Recurrent abscess formation (HP:0002722)3.10606704
21Colitis (HP:0002583)3.07690174
22Myositis (HP:0100614)3.03931671
23Meningitis (HP:0001287)2.98529967
24Papilledema (HP:0001085)2.94528905
25Recurrent bronchitis (HP:0002837)2.94036007
26Recurrent skin infections (HP:0001581)2.93303929
27Fatigue (HP:0012378)2.92917616
28Granulocytopenia (HP:0001913)2.92141891
29Retrobulbar optic neuritis (HP:0100654)2.91999033
30Optic neuritis (HP:0100653)2.91999033
31Thyroiditis (HP:0100646)2.91665100
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.90503846
33Vasculitis (HP:0002633)2.89227591
34Keratoconjunctivitis (HP:0001096)2.86320335
35Abnormality of T cell physiology (HP:0011840)2.84774038
36Eosinophilia (HP:0001880)2.78466258
37Acute myeloid leukemia (HP:0004808)2.78424509
38Increased IgE level (HP:0003212)2.76610954
39Keratoconjunctivitis sicca (HP:0001097)2.72631526
40Inflammation of the large intestine (HP:0002037)2.72045678
41Pustule (HP:0200039)2.71709116
42Papilloma (HP:0012740)2.68442509
43Verrucae (HP:0200043)2.68442509
44Papillary thyroid carcinoma (HP:0002895)2.65332231
45Orchitis (HP:0100796)2.64913686
46Abnormality of eosinophils (HP:0001879)2.63935049
47Hypoplasia of the thymus (HP:0000778)2.63929049
48Encephalitis (HP:0002383)2.60757402
49Gastrointestinal inflammation (HP:0004386)2.59746338
50Viral hepatitis (HP:0006562)2.59654709
51Combined immunodeficiency (HP:0005387)2.54338300
52Osteomyelitis (HP:0002754)2.50351256
53Spontaneous hematomas (HP:0007420)2.49500037
54Metaphyseal dysplasia (HP:0100255)2.48583127
55Leukocytosis (HP:0001974)2.47872841
56Abnormality of macrophages (HP:0004311)2.45405058
57Cellulitis (HP:0100658)2.42934283
58Chronic diarrhea (HP:0002028)2.42443597
59Menstrual irregularities (HP:0000858)2.41057896
60Basal cell carcinoma (HP:0002671)2.31161886
61Anhidrosis (HP:0000970)2.28343482
62Autoimmune thrombocytopenia (HP:0001973)2.28104363
63Lymphopenia (HP:0001888)2.27783531
64Hematochezia (HP:0002573)2.26202430
65Pulmonary infiltrates (HP:0002113)2.23655171
66Stomach cancer (HP:0012126)2.21316102
67IgM deficiency (HP:0002850)2.20510051
68Prolonged bleeding time (HP:0003010)2.16774971
69Keratitis (HP:0000491)2.15316972
70IgG deficiency (HP:0004315)2.14709885
71Abnormality of the prostate (HP:0008775)2.08059938
72Slow saccadic eye movements (HP:0000514)2.05362357
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.05308855
74Syringomyelia (HP:0003396)2.03085215
75Spinal cord lesions (HP:0100561)2.03085215
76Gastrointestinal stroma tumor (HP:0100723)1.99534869
77Gastrointestinal infarctions (HP:0005244)1.98156750
78Recurrent gram-negative bacterial infections (HP:0005420)1.97572755
79Thyroid carcinoma (HP:0002890)1.96689809
80Gingivitis (HP:0000230)1.96016876
81Neoplasm of the tracheobronchial system (HP:0100552)1.95267566
82Sepsis (HP:0100806)1.94223815
83Urticaria (HP:0001025)1.90665971
84Prominent nose (HP:0000448)1.90289886
85Abnormality of the fingertips (HP:0001211)1.89780755
86Gingival bleeding (HP:0000225)1.88871599
87Subacute progressive viral hepatitis (HP:0006572)1.88194913
88Dry hair (HP:0011359)1.86513345
89Epistaxis (HP:0000421)1.84700353
90Lymphoma (HP:0002665)1.84465218
91Aplasia/Hypoplasia of the thymus (HP:0010515)1.82928279
92Fair hair (HP:0002286)1.82909627
93Gangrene (HP:0100758)1.82081693
94Chest pain (HP:0100749)1.81650099
95Exocrine pancreatic insufficiency (HP:0001738)1.81486146
96Recurrent sinusitis (HP:0011108)1.79184660
97Increased CSF protein (HP:0002922)1.78665859
98Chronic obstructive pulmonary disease (HP:0006510)1.77775994
99Obstructive lung disease (HP:0006536)1.77775994
100Hemoptysis (HP:0002105)1.75093865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.15258537
2MAP3K142.69929681
3BMPR22.67916935
4RIPK42.56005286
5IKBKE2.54183571
6MAP4K12.50005883
7PRPF4B2.32294467
8IRAK42.27653497
9FRK2.17192877
10BTK2.03555840
11SCYL22.03094501
12TYK21.95441622
13TEC1.95354468
14JAK11.93041074
15PIK3CG1.85907170
16BRD41.84951083
17BLK1.83622733
18TXK1.82218916
19NEK91.80908459
20SIK31.75632573
21EIF2AK31.69499415
22ITK1.69022557
23SYK1.65235945
24NLK1.64314215
25CDK121.59439209
26FGFR31.53256578
27IKBKB1.53034426
28IRAK11.49149209
29MAP3K21.42112905
30AKT31.40664228
31TBK11.36361112
32GRK61.35993159
33CAMKK21.35211757
34ERBB31.34576347
35MARK31.31949814
36PASK1.29052958
37MST41.27873955
38JAK31.25970039
39CSK1.24693604
40MAP3K131.21968332
41TRPM71.18384392
42KIT1.16473238
43HCK1.16230272
44PIM11.16127630
45MAP2K31.14281542
46ZAP701.13834065
47LCK1.10906345
48STK101.10866076
49LYN1.08834202
50JAK21.07253052
51MAP3K121.06528173
52YES11.06244238
53CDK61.05677399
54FES1.00191794
55MAPK70.97466410
56MAP3K100.93549245
57MAP3K50.92195986
58IRAK20.91795470
59MAP3K10.83540271
60KSR10.81257177
61CHUK0.80199956
62HIPK20.79207346
63PRKCQ0.77753787
64MAPK110.76573694
65MAP3K60.73529501
66STK240.73041605
67WNK10.72789423
68SGK20.68830152
69DYRK1B0.68675297
70IRAK30.68137466
71CSF1R0.67258398
72EPHA30.66959485
73CLK10.65505898
74MAP3K30.65424624
75PDK10.62516086
76MELK0.59216909
77MAPK120.56624538
78PIK3CA0.53670505
79MAP4K20.53479095
80ABL10.51712778
81RAF10.51286585
82STK30.50496196
83TNK20.49665094
84CDK40.49155532
85GRK70.49017613
86RPS6KA40.47035258
87SIK20.43699209
88SGK30.43695727
89NEK60.39689603
90MARK20.39303175
91CCNB10.37551476
92ACVR1B0.37204180
93TRIM280.36245327
94EGFR0.29801351
95DYRK30.29765325
96MAP3K40.29089448
97MAPK30.28624145
98RPS6KA50.28551212
99RET0.28102768
100KSR20.26696406

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.90454415
2B cell receptor signaling pathway_Homo sapiens_hsa046622.74862230
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.32962896
4T cell receptor signaling pathway_Homo sapiens_hsa046602.31558302
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.25653269
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20347398
7Allograft rejection_Homo sapiens_hsa053302.15868339
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14310195
9Graft-versus-host disease_Homo sapiens_hsa053322.13553076
10Osteoclast differentiation_Homo sapiens_hsa043802.10551475
11Leishmaniasis_Homo sapiens_hsa051402.09479236
12Measles_Homo sapiens_hsa051622.09110101
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.07140023
14Autoimmune thyroid disease_Homo sapiens_hsa053202.01095166
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91661168
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.90640830
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.82852936
18Acute myeloid leukemia_Homo sapiens_hsa052211.78464708
19Type I diabetes mellitus_Homo sapiens_hsa049401.71981283
20Herpes simplex infection_Homo sapiens_hsa051681.67159694
21Hepatitis B_Homo sapiens_hsa051611.66836434
22Hematopoietic cell lineage_Homo sapiens_hsa046401.63771859
23Asthma_Homo sapiens_hsa053101.62158605
24TNF signaling pathway_Homo sapiens_hsa046681.59053346
25Non-small cell lung cancer_Homo sapiens_hsa052231.58940388
26Influenza A_Homo sapiens_hsa051641.57856371
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54037699
28Pancreatic cancer_Homo sapiens_hsa052121.47978519
29Tuberculosis_Homo sapiens_hsa051521.47844202
30Toxoplasmosis_Homo sapiens_hsa051451.40512420
31Legionellosis_Homo sapiens_hsa051341.33632820
32Dorso-ventral axis formation_Homo sapiens_hsa043201.30163995
33Chronic myeloid leukemia_Homo sapiens_hsa052201.29377034
34Staphylococcus aureus infection_Homo sapiens_hsa051501.21131261
35Renal cell carcinoma_Homo sapiens_hsa052111.17816091
36Prolactin signaling pathway_Homo sapiens_hsa049171.16503732
37FoxO signaling pathway_Homo sapiens_hsa040681.15612867
38Antigen processing and presentation_Homo sapiens_hsa046121.15056768
39Chemokine signaling pathway_Homo sapiens_hsa040621.14714230
40Viral carcinogenesis_Homo sapiens_hsa052031.13041728
41Hepatitis C_Homo sapiens_hsa051601.11952734
42Malaria_Homo sapiens_hsa051441.06755508
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05135099
44Other glycan degradation_Homo sapiens_hsa005111.05028345
45Viral myocarditis_Homo sapiens_hsa054161.05026941
46Platelet activation_Homo sapiens_hsa046111.03882093
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02132671
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00883218
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00654727
50Circadian rhythm_Homo sapiens_hsa047101.00303439
51Inositol phosphate metabolism_Homo sapiens_hsa005621.00250902
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.93849462
53Epstein-Barr virus infection_Homo sapiens_hsa051690.93736378
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93656033
55Prostate cancer_Homo sapiens_hsa052150.93296032
56mTOR signaling pathway_Homo sapiens_hsa041500.92361596
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92232198
58Colorectal cancer_Homo sapiens_hsa052100.89236802
59Rheumatoid arthritis_Homo sapiens_hsa053230.88413011
60Systemic lupus erythematosus_Homo sapiens_hsa053220.87946111
61Shigellosis_Homo sapiens_hsa051310.83309213
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82883136
63Endometrial cancer_Homo sapiens_hsa052130.80894809
64Apoptosis_Homo sapiens_hsa042100.80179358
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.76890093
66HTLV-I infection_Homo sapiens_hsa051660.75319173
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72208348
68VEGF signaling pathway_Homo sapiens_hsa043700.71916116
69Type II diabetes mellitus_Homo sapiens_hsa049300.69011736
70Non-homologous end-joining_Homo sapiens_hsa034500.68445547
71Pertussis_Homo sapiens_hsa051330.66239157
72ErbB signaling pathway_Homo sapiens_hsa040120.66177655
73Insulin resistance_Homo sapiens_hsa049310.66092832
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65762639
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.64588345
76Small cell lung cancer_Homo sapiens_hsa052220.63586532
77Regulation of autophagy_Homo sapiens_hsa041400.61895399
78Choline metabolism in cancer_Homo sapiens_hsa052310.61792966
79African trypanosomiasis_Homo sapiens_hsa051430.58680613
80p53 signaling pathway_Homo sapiens_hsa041150.58221920
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58154620
82Glioma_Homo sapiens_hsa052140.57390572
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55079963
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53602401
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51507476
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51291603
87Salmonella infection_Homo sapiens_hsa051320.50047199
88MAPK signaling pathway_Homo sapiens_hsa040100.48540123
89Thyroid cancer_Homo sapiens_hsa052160.48136617
90HIF-1 signaling pathway_Homo sapiens_hsa040660.47267633
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46338312
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.42717965
93Fanconi anemia pathway_Homo sapiens_hsa034600.41678573
94MicroRNAs in cancer_Homo sapiens_hsa052060.39586534
95RNA degradation_Homo sapiens_hsa030180.37530178
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37163983
97Phagosome_Homo sapiens_hsa041450.36788611
98Alcoholism_Homo sapiens_hsa050340.36188465
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35945337
100Sphingolipid metabolism_Homo sapiens_hsa006000.33454079

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