ZNF804A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase catabolic process (GO:0046113)8.62981640
2central nervous system projection neuron axonogenesis (GO:0021952)5.32286938
3positive regulation of dendritic spine morphogenesis (GO:0061003)4.83204089
4positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.61350588
5regulation of feeding behavior (GO:0060259)4.52732046
6neuron recognition (GO:0008038)4.47882666
7regulation of synapse structural plasticity (GO:0051823)4.41289636
8neuron cell-cell adhesion (GO:0007158)4.32503969
9layer formation in cerebral cortex (GO:0021819)4.31892107
10presynaptic membrane assembly (GO:0097105)4.28840198
11central nervous system neuron axonogenesis (GO:0021955)4.27958551
12cell migration in hindbrain (GO:0021535)4.24815494
13postsynaptic membrane organization (GO:0001941)4.18123668
14synaptic vesicle maturation (GO:0016188)4.12284268
15establishment of mitochondrion localization (GO:0051654)4.02700051
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02063071
17protein localization to synapse (GO:0035418)3.92488950
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92279613
19presynaptic membrane organization (GO:0097090)3.92176181
20G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.90651856
21synaptic vesicle exocytosis (GO:0016079)3.75723914
22neurofilament cytoskeleton organization (GO:0060052)3.72168075
23axonal fasciculation (GO:0007413)3.71399226
24pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.71229749
25UMP biosynthetic process (GO:0006222)3.71229749
26pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.71229749
27UMP metabolic process (GO:0046049)3.71229749
28mitochondrion transport along microtubule (GO:0047497)3.66511507
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.66511507
30glycosphingolipid biosynthetic process (GO:0006688)3.65237298
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65057793
32positive regulation of synapse assembly (GO:0051965)3.63143508
33epithelial cell differentiation involved in kidney development (GO:0035850)3.61348251
34retinal ganglion cell axon guidance (GO:0031290)3.57880220
35dendritic spine morphogenesis (GO:0060997)3.54149300
36regulation of synapse assembly (GO:0051963)3.47173951
37synaptic transmission, glutamatergic (GO:0035249)3.44593922
38vocalization behavior (GO:0071625)3.43847740
39pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.43034109
40atrial cardiac muscle cell action potential (GO:0086014)3.42411813
41sympathetic nervous system development (GO:0048485)3.38937005
42facial nerve structural organization (GO:0021612)3.37638825
43positive regulation of potassium ion transmembrane transport (GO:1901381)3.34128121
44regulation of dendritic spine morphogenesis (GO:0061001)3.31309758
45pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.30754266
46axon extension (GO:0048675)3.30276598
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29676647
48neurotransmitter-gated ion channel clustering (GO:0072578)3.26313562
49nerve growth factor signaling pathway (GO:0038180)3.26213769
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.23461476
51neuron-neuron synaptic transmission (GO:0007270)3.20973313
52regulation of glutamate receptor signaling pathway (GO:1900449)3.20583439
53positive regulation of dendritic spine development (GO:0060999)3.15031503
54synapse assembly (GO:0007416)3.13021965
55negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.12760275
56cardiac ventricle formation (GO:0003211)3.10996204
57ganglioside metabolic process (GO:0001573)3.10411217
58protein localization to cilium (GO:0061512)3.09599584
59response to pheromone (GO:0019236)3.08753368
60spinal cord development (GO:0021510)3.05498254
61regulation of synapse organization (GO:0050807)3.04869158
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04447814
63response to nerve growth factor (GO:1990089)3.03445750
64cellular response to nerve growth factor stimulus (GO:1990090)3.03445750
65ganglion development (GO:0061548)3.01777512
66response to methylmercury (GO:0051597)3.01134935
67pyrimidine nucleobase metabolic process (GO:0006206)2.99404609
68regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98625025
69protein polyglutamylation (GO:0018095)2.98175629
70positive regulation of dendrite morphogenesis (GO:0050775)2.97849269
71dendrite morphogenesis (GO:0048813)2.94643432
72negative regulation of mast cell activation (GO:0033004)2.93566955
73behavioral response to nicotine (GO:0035095)2.92960756
74regulation of dendritic spine development (GO:0060998)2.92493682
75regulation of axon extension (GO:0030516)2.92473030
76positive regulation of synapse maturation (GO:0090129)2.92290380
77grooming behavior (GO:0007625)2.91557057
78positive regulation of amino acid transport (GO:0051957)2.91239407
79regulation of synaptic transmission, glutamatergic (GO:0051966)2.89969387
80cranial nerve morphogenesis (GO:0021602)2.88591964
81organelle transport along microtubule (GO:0072384)2.88179195
82regulation of vesicle fusion (GO:0031338)2.88164796
83sialylation (GO:0097503)2.87932731
84sarcoplasmic reticulum calcium ion transport (GO:0070296)2.87828790
85phosphorelay signal transduction system (GO:0000160)2.85796378
86cerebral cortex radially oriented cell migration (GO:0021799)2.83851158
87regulation of postsynaptic membrane potential (GO:0060078)2.83242527
88glutamate receptor signaling pathway (GO:0007215)2.82685722
89neuron projection extension (GO:1990138)2.81948941
90axonogenesis (GO:0007409)2.80479617
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79310866
92cardiac chamber formation (GO:0003207)2.77823613
93neuronal action potential (GO:0019228)2.77013918
94pyrimidine-containing compound catabolic process (GO:0072529)2.75252454
95negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75079308
96adult walking behavior (GO:0007628)2.74718961
97positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.73173553
98positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73001641
99clathrin coat assembly (GO:0048268)2.70918321
100pyrimidine nucleobase catabolic process (GO:0006208)11.1990729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.83165237
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.87064990
3GBX2_23144817_ChIP-Seq_PC3_Human3.57439147
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.11270225
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.87733080
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87250333
7TAF15_26573619_Chip-Seq_HEK293_Human2.86115795
8REST_21632747_ChIP-Seq_MESCs_Mouse2.63861782
9* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.54203578
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51711865
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31348015
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30850412
13RNF2_27304074_Chip-Seq_NSC_Mouse2.23665690
14* ZNF274_21170338_ChIP-Seq_K562_Hela2.19328627
15IGF1R_20145208_ChIP-Seq_DFB_Human2.16486844
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16442418
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.12845511
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06618951
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04816938
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.00935189
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00067971
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99226766
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97530583
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93644786
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86037494
26* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84143564
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83835277
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80962904
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.80122901
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.79434245
31* FUS_26573619_Chip-Seq_HEK293_Human1.79008828
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.77388435
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75017887
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74188886
35P300_19829295_ChIP-Seq_ESCs_Human1.68559844
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66280402
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65051226
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65051226
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61893223
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.58063299
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.55637039
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55316121
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.53301356
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52396301
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52172283
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.52078469
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.48879787
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47019124
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45975904
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44020392
51* EWS_26573619_Chip-Seq_HEK293_Human1.43972045
52TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.42227905
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41828280
54KDM2B_26808549_Chip-Seq_REH_Human1.40461827
55* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40177110
56DROSHA_22980978_ChIP-Seq_HELA_Human1.38817763
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38683427
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35478675
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30680794
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.30502708
61* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30466653
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28621178
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28621178
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28478900
65* AR_25329375_ChIP-Seq_VCAP_Human1.26313648
66* STAT3_23295773_ChIP-Seq_U87_Human1.26158266
67* TCF4_23295773_ChIP-Seq_U87_Human1.25831311
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.25293457
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24764352
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23664595
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23664595
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21655668
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20632422
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20067138
75VDR_24787735_ChIP-Seq_THP-1_Human1.19680935
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18958907
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17348735
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17337188
79JUN_21703547_ChIP-Seq_K562_Human1.10040271
80TP53_16413492_ChIP-PET_HCT116_Human1.09813895
81ER_23166858_ChIP-Seq_MCF-7_Human1.09626403
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08884745
83* PIAS1_25552417_ChIP-Seq_VCAP_Human1.08286996
84* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05313586
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04796140
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.04377731
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.04229338
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04097739
89CBP_20019798_ChIP-Seq_JUKART_Human1.04097739
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03835430
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02214678
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.01119463
93SOX9_26525672_Chip-Seq_HEART_Mouse1.00124909
94TAL1_26923725_Chip-Seq_HPCs_Mouse0.99600511
95* RUNX2_22187159_ChIP-Seq_PCA_Human0.99437462
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98642517
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97648992
98RING1B_27294783_Chip-Seq_ESCs_Mouse0.96566135
99WT1_19549856_ChIP-ChIP_CCG9911_Human0.96185334
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96097609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.85431723
2MP0003880_abnormal_central_pattern4.11035301
3MP0002735_abnormal_chemical_nociception3.73145340
4MP0003635_abnormal_synaptic_transmissio3.07455020
5MP0004270_analgesia3.00491260
6MP0001986_abnormal_taste_sensitivity2.95590801
7MP0000778_abnormal_nervous_system2.72781022
8MP0009046_muscle_twitch2.72450232
9MP0002063_abnormal_learning/memory/cond2.70040833
10MP0005423_abnormal_somatic_nervous2.68522465
11MP0002734_abnormal_mechanical_nocicepti2.62096211
12MP0003303_peritoneal_inflammation2.56104116
13MP0002822_catalepsy2.50689169
14MP0009745_abnormal_behavioral_response2.43149573
15MP0003787_abnormal_imprinting2.38276258
16MP0002064_seizures2.34402993
17MP0001968_abnormal_touch/_nociception2.34127823
18MP0001486_abnormal_startle_reflex2.27858840
19MP0002572_abnormal_emotion/affect_behav2.25980637
20MP0001970_abnormal_pain_threshold2.19469146
21MP0005367_renal/urinary_system_phenotyp2.18532934
22MP0000516_abnormal_urinary_system2.18532934
23MP0002733_abnormal_thermal_nociception2.09690795
24MP0002272_abnormal_nervous_system2.07904580
25MP0004811_abnormal_neuron_physiology1.95815902
26MP0002751_abnormal_autonomic_nervous1.90548552
27MP0002067_abnormal_sensory_capabilities1.89842396
28MP0003329_amyloid_beta_deposits1.86142447
29MP0000955_abnormal_spinal_cord1.82265949
30MP0010386_abnormal_urinary_bladder1.81317849
31MP0006276_abnormal_autonomic_nervous1.81124721
32MP0000569_abnormal_digit_pigmentation1.76886288
33MP0001440_abnormal_grooming_behavior1.70008968
34MP0004924_abnormal_behavior1.64095780
35MP0005386_behavior/neurological_phenoty1.64095780
36MP0000604_amyloidosis1.59775266
37MP0004742_abnormal_vestibular_system1.55960897
38MP0002736_abnormal_nociception_after1.55227375
39MP0003633_abnormal_nervous_system1.53302968
40MP0002882_abnormal_neuron_morphology1.52427322
41MP0005187_abnormal_penis_morphology1.51466936
42MP0001501_abnormal_sleep_pattern1.51027856
43MP0002184_abnormal_innervation1.48661539
44MP0002557_abnormal_social/conspecific_i1.44723424
45MP0003121_genomic_imprinting1.42237129
46MP0005645_abnormal_hypothalamus_physiol1.41080069
47MP0001529_abnormal_vocalization1.35916580
48MP0002152_abnormal_brain_morphology1.34449932
49MP0004142_abnormal_muscle_tone1.30170945
50MP0004510_myositis1.23019040
51MP0003631_nervous_system_phenotype1.20835948
52MP0002066_abnormal_motor_capabilities/c1.16789407
53MP0005310_abnormal_salivary_gland1.11102549
54MP0008569_lethality_at_weaning1.08509599
55MP0003122_maternal_imprinting1.08405157
56MP0001984_abnormal_olfaction1.06427178
57MP0001905_abnormal_dopamine_level1.03844560
58MP0008872_abnormal_physiological_respon1.00737135
59MP0005646_abnormal_pituitary_gland0.99169307
60MP0002752_abnormal_somatic_nervous0.93237409
61MP0003656_abnormal_erythrocyte_physiolo0.92840441
62MP0006054_spinal_hemorrhage0.92787941
63MP0003861_abnormal_nervous_system0.89207406
64MP0003690_abnormal_glial_cell0.87042224
65MP0004133_heterotaxia0.86408343
66MP0002069_abnormal_eating/drinking_beha0.81855344
67MP0001835_abnormal_antigen_presentation0.80729210
68MP0002229_neurodegeneration0.80092454
69MP0003221_abnormal_cardiomyocyte_apopto0.79993620
70MP0003632_abnormal_nervous_system0.78175522
71MP0000534_abnormal_ureter_morphology0.76940793
72MP0002653_abnormal_ependyma_morphology0.76310492
73MP0003075_altered_response_to0.75906666
74MP0000465_gastrointestinal_hemorrhage0.71709353
75MP0003195_calcinosis0.70062871
76MP0002082_postnatal_lethality0.68887430
77MP0010770_preweaning_lethality0.68887430
78MP0004145_abnormal_muscle_electrophysio0.67078765
79MP0003634_abnormal_glial_cell0.65879654
80MP0005334_abnormal_fat_pad0.64269493
81MP0008874_decreased_physiological_sensi0.63566084
82MP0002148_abnormal_hypersensitivity_rea0.63421240
83MP0001188_hyperpigmentation0.63120989
84MP0010769_abnormal_survival0.62805621
85MP0009764_decreased_sensitivity_to0.61817487
86MP0002928_abnormal_bile_duct0.61428363
87MP0002332_abnormal_exercise_endurance0.60556455
88MP0010768_mortality/aging0.60414962
89MP0003948_abnormal_gas_homeostasis0.59161221
90MP0005084_abnormal_gallbladder_morpholo0.57571702
91MP0002081_perinatal_lethality0.56049979
92MP0005195_abnormal_posterior_eye0.55109054
93MP0005551_abnormal_eye_electrophysiolog0.54585371
94MP0003868_abnormal_feces_composition0.54264274
95MP0000920_abnormal_myelination0.53590562
96MP0002234_abnormal_pharynx_morphology0.53057517
97MP0008995_early_reproductive_senescence0.49661085
98MP0003698_abnormal_male_reproductive0.49363359
99MP0008770_decreased_survivor_rate0.47717979
100MP0001542_abnormal_bone_strength0.46897497

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.34876424
2Focal seizures (HP:0007359)5.52156844
3Febrile seizures (HP:0002373)4.61258044
4Amyotrophic lateral sclerosis (HP:0007354)4.50975303
5Progressive cerebellar ataxia (HP:0002073)3.82840320
6Hyperventilation (HP:0002883)3.82690158
7Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.75524919
8Drooling (HP:0002307)3.72929621
9Broad-based gait (HP:0002136)3.68551143
10Myokymia (HP:0002411)3.63772564
11Mutism (HP:0002300)3.62769050
12Excessive salivation (HP:0003781)3.53094036
13Tetraplegia (HP:0002445)3.49878446
14Urinary urgency (HP:0000012)3.38799419
15Urinary bladder sphincter dysfunction (HP:0002839)3.35378144
16Pachygyria (HP:0001302)3.34316629
17Inappropriate behavior (HP:0000719)3.30639323
18Epileptic encephalopathy (HP:0200134)3.22071739
19Dialeptic seizures (HP:0011146)3.21434417
20Peripheral hypomyelination (HP:0007182)3.15255386
21Action tremor (HP:0002345)3.11628864
22Disinhibition (HP:0000734)3.07561996
23Gaze-evoked nystagmus (HP:0000640)3.07337688
24Ulnar claw (HP:0001178)3.07070221
25Lissencephaly (HP:0001339)3.05438707
26Atonic seizures (HP:0010819)3.02286360
27Genetic anticipation (HP:0003743)3.01244220
28Generalized tonic-clonic seizures (HP:0002069)2.99120293
29Dysdiadochokinesis (HP:0002075)2.95310496
30Poor eye contact (HP:0000817)2.95260242
31Neurofibrillary tangles (HP:0002185)2.89591885
32Abnormality of pyrimidine metabolism (HP:0004353)2.88299529
33Polyphagia (HP:0002591)2.84169244
34Absence seizures (HP:0002121)2.79994339
35Inability to walk (HP:0002540)2.73620282
36Protruding tongue (HP:0010808)2.69672155
37Agnosia (HP:0010524)2.64958948
38Intention tremor (HP:0002080)2.62618688
39Retinal dysplasia (HP:0007973)2.62464693
40Diminished motivation (HP:0000745)2.55726389
41Failure to thrive in infancy (HP:0001531)2.53633983
42Spastic tetraparesis (HP:0001285)2.53187923
43Abnormality of the corticospinal tract (HP:0002492)2.50710681
44Spastic gait (HP:0002064)2.49181342
45Aplasia/Hypoplasia of the brainstem (HP:0007362)2.47715373
46Hypoplasia of the brainstem (HP:0002365)2.47715373
47Apathy (HP:0000741)2.47225488
48Abnormality of salivation (HP:0100755)2.45904163
49Exotropia (HP:0000577)2.45203755
50Cortical dysplasia (HP:0002539)2.44180485
51Absent speech (HP:0001344)2.38941894
52Insidious onset (HP:0003587)2.37842508
53Termporal pattern (HP:0011008)2.37842508
54Scanning speech (HP:0002168)2.35537480
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.31027451
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31027451
57Progressive inability to walk (HP:0002505)2.28379729
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.28008176
59Chronic otitis media (HP:0000389)2.27688069
60Dysmetria (HP:0001310)2.27655870
61Impaired vibration sensation in the lower limbs (HP:0002166)2.22137802
62Lower limb muscle weakness (HP:0007340)2.21408333
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19528406
64Recurrent cutaneous fungal infections (HP:0011370)2.17499858
65Chronic mucocutaneous candidiasis (HP:0002728)2.17499858
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.12860406
67Abnormal social behavior (HP:0012433)2.11790771
68Impaired social interactions (HP:0000735)2.11790771
69Agitation (HP:0000713)2.11717651
70Large earlobe (HP:0009748)2.11449864
71Visual hallucinations (HP:0002367)2.09358739
72Gait imbalance (HP:0002141)2.09347416
73Hypoplasia of the corpus callosum (HP:0002079)2.07660238
74Abnormal eating behavior (HP:0100738)2.07304584
75Abnormality of lateral ventricle (HP:0030047)2.05285137
76Delusions (HP:0000746)2.04867051
77Neuronal loss in central nervous system (HP:0002529)2.01287935
78Cerebral inclusion bodies (HP:0100314)2.00276990
79Epileptiform EEG discharges (HP:0011182)1.99352557
80Intellectual disability, severe (HP:0010864)1.98349752
81EEG with generalized epileptiform discharges (HP:0011198)1.98347716
82Amblyopia (HP:0000646)1.95659022
83Pancreatic fibrosis (HP:0100732)1.93150267
84Hypsarrhythmia (HP:0002521)1.92961883
85Hemiparesis (HP:0001269)1.92406975
86Abnormality of the hip-girdle musculature (HP:0001445)1.90955715
87Abnormality of the musculature of the pelvis (HP:0001469)1.90955715
88Bradycardia (HP:0001662)1.90414800
89Limb dystonia (HP:0002451)1.90089289
90Tented upper lip vermilion (HP:0010804)1.89785863
91Frequent falls (HP:0002359)1.87207274
92Postural instability (HP:0002172)1.86828024
93Supranuclear gaze palsy (HP:0000605)1.86210325
94Medulloblastoma (HP:0002885)1.82953248
95Diplopia (HP:0000651)1.82527430
96Abnormality of binocular vision (HP:0011514)1.82527430
97Truncal ataxia (HP:0002078)1.81853800
98Heterotopia (HP:0002282)1.81326859
99Impaired vibratory sensation (HP:0002495)1.78607548
100Abnormality of ocular smooth pursuit (HP:0000617)1.78569798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.48704309
2CASK3.42234957
3EPHA42.66233794
4SIK22.64293871
5MAP3K42.54402420
6CCNB12.33474220
7MAP2K72.31473802
8NTRK32.19173557
9MINK12.13518209
10CAMKK21.88297389
11PINK11.83894218
12NTRK21.82760293
13MAP2K41.74110148
14MAPK131.71924725
15MAP4K21.66645974
16FRK1.64215017
17DYRK31.60403238
18GRK71.59204791
19NEK11.58889035
20NTRK11.55120105
21DYRK21.48626261
22RIPK41.48003710
23SIK31.47481299
24CLK11.45454888
25WNK31.39483165
26TAOK11.39339765
27DAPK21.36392574
28MAP3K61.32560542
29ADRBK21.30851180
30KSR11.25038200
31BCR1.23338429
32RPS6KA41.08097231
33UHMK11.06137636
34DYRK1A1.03204518
35IRAK31.02473198
36CAMKK10.97334268
37EPHB20.96178686
38MAP3K110.95207507
39CDK50.95055499
40CAMK40.93011911
41CDK80.91381450
42STK110.90987413
43PAK60.90330300
44CSNK1G20.89960702
45DAPK10.87532320
46CAMK2A0.84547230
47MAPK40.80069415
48LIMK10.79282252
49RPS6KA20.78916430
50MAPK120.75961037
51TRIM280.75928415
52FES0.75620444
53PRKCZ0.71949336
54CAMK2B0.71878781
55PKN10.71017845
56ADRBK10.70951308
57INSRR0.70801568
58PRKCG0.68812932
59KIT0.66608670
60PLK40.66274857
61BLK0.66195236
62ERBB30.64899220
63SYK0.63744871
64MAP3K50.63335505
65PLK20.62414555
66PAK30.59306053
67TYRO30.54508418
68CSNK1G30.53553397
69CDK180.53404173
70ABL20.52399063
71MARK20.51279747
72CDK140.50372658
73CDK150.48822899
74NEK20.48348417
75YES10.46437231
76CAMK10.46426436
77MATK0.46424795
78SGK20.46184288
79CSNK1A1L0.44858892
80MAP2K30.44046670
81RPS6KA60.42481219
82ICK0.41947917
83RPS6KC10.41333539
84RPS6KL10.41333539
85PNCK0.41286799
86PRKCE0.41220276
87CDK11A0.40298514
88FLT30.38676137
89TEC0.38543134
90STK160.37599320
91DYRK1B0.37337322
92ACVR1B0.37214882
93SGK4940.36919416
94SGK2230.36919416
95CSNK1D0.35247776
96FYN0.34486698
97PRKD10.33418215
98BMPR1B0.32363378
99MAPK80.32322587
100PRKG10.31690505

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.79525535
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82332876
3Synaptic vesicle cycle_Homo sapiens_hsa047212.68464097
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.43955817
5Morphine addiction_Homo sapiens_hsa050322.25009742
6Cholinergic synapse_Homo sapiens_hsa047252.24823325
7Glutamatergic synapse_Homo sapiens_hsa047242.14745992
8Circadian entrainment_Homo sapiens_hsa047132.09154741
9GABAergic synapse_Homo sapiens_hsa047272.04407033
10Dopaminergic synapse_Homo sapiens_hsa047282.00506171
11Cocaine addiction_Homo sapiens_hsa050301.96383986
12Dorso-ventral axis formation_Homo sapiens_hsa043201.88409056
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78414481
14Axon guidance_Homo sapiens_hsa043601.76695724
15Salivary secretion_Homo sapiens_hsa049701.59960102
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54076294
17Long-term potentiation_Homo sapiens_hsa047201.53836029
18Amphetamine addiction_Homo sapiens_hsa050311.53289759
19Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.53100954
20Long-term depression_Homo sapiens_hsa047301.50365471
21Taste transduction_Homo sapiens_hsa047421.44135963
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39648081
23Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36306130
24Gap junction_Homo sapiens_hsa045401.34272706
25Estrogen signaling pathway_Homo sapiens_hsa049151.32841936
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29997203
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27347314
28Oxytocin signaling pathway_Homo sapiens_hsa049211.26103992
29Gastric acid secretion_Homo sapiens_hsa049711.21370066
30Renin secretion_Homo sapiens_hsa049241.20711705
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19463018
32Calcium signaling pathway_Homo sapiens_hsa040201.17350066
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13715991
34Serotonergic synapse_Homo sapiens_hsa047261.12134138
35Phagosome_Homo sapiens_hsa041451.11887246
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11184615
37Osteoclast differentiation_Homo sapiens_hsa043801.11101202
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09955386
39Alcoholism_Homo sapiens_hsa050341.09923253
40Insulin secretion_Homo sapiens_hsa049111.08502773
41Collecting duct acid secretion_Homo sapiens_hsa049661.07827699
42Olfactory transduction_Homo sapiens_hsa047401.04097808
43Tuberculosis_Homo sapiens_hsa051521.03407201
44Salmonella infection_Homo sapiens_hsa051321.02724173
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.00867341
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00701213
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.99056357
48B cell receptor signaling pathway_Homo sapiens_hsa046620.96481732
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93943202
50cAMP signaling pathway_Homo sapiens_hsa040240.93083991
51Rheumatoid arthritis_Homo sapiens_hsa053230.92748668
52Type II diabetes mellitus_Homo sapiens_hsa049300.91384864
53African trypanosomiasis_Homo sapiens_hsa051430.89219073
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88930603
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.87353714
56Glioma_Homo sapiens_hsa052140.85861917
57GnRH signaling pathway_Homo sapiens_hsa049120.85152554
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83979282
59Ovarian steroidogenesis_Homo sapiens_hsa049130.82930443
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81653190
61Prolactin signaling pathway_Homo sapiens_hsa049170.81137409
62Platelet activation_Homo sapiens_hsa046110.80984979
63Chemokine signaling pathway_Homo sapiens_hsa040620.79261950
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78659184
65Phototransduction_Homo sapiens_hsa047440.78025372
66Ras signaling pathway_Homo sapiens_hsa040140.77083158
67Leishmaniasis_Homo sapiens_hsa051400.75573800
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74355536
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74308819
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74264205
71ErbB signaling pathway_Homo sapiens_hsa040120.73939080
72MAPK signaling pathway_Homo sapiens_hsa040100.70968005
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68968760
74Shigellosis_Homo sapiens_hsa051310.67409487
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63973156
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62259748
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61110158
78Ether lipid metabolism_Homo sapiens_hsa005650.58887881
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55860242
80Inositol phosphate metabolism_Homo sapiens_hsa005620.55643336
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52489249
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51981503
83Pyrimidine metabolism_Homo sapiens_hsa002400.50323741
84Rap1 signaling pathway_Homo sapiens_hsa040150.49987791
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49970311
86Pertussis_Homo sapiens_hsa051330.45769555
87Lysosome_Homo sapiens_hsa041420.44720043
88TNF signaling pathway_Homo sapiens_hsa046680.44657788
89Asthma_Homo sapiens_hsa053100.44228067
90Chronic myeloid leukemia_Homo sapiens_hsa052200.43100052
91Hepatitis B_Homo sapiens_hsa051610.42719093
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40518041
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.40343234
94Dilated cardiomyopathy_Homo sapiens_hsa054140.40151544
95mTOR signaling pathway_Homo sapiens_hsa041500.38527910
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38496462
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.38115887
98Basal transcription factors_Homo sapiens_hsa030220.36625922
99Cardiac muscle contraction_Homo sapiens_hsa042600.34864617
100Vibrio cholerae infection_Homo sapiens_hsa051100.34821649

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