ZNF804B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine ribonucleotide transport (GO:0015868)9.65210652
2adenine nucleotide transport (GO:0051503)9.59656677
3centriole replication (GO:0007099)7.70831711
4purine nucleotide transport (GO:0015865)7.59106821
5peptidyl-arginine modification (GO:0018195)7.57959948
6inositol phosphate-mediated signaling (GO:0048016)6.84043941
7positive regulation of guanylate cyclase activity (GO:0031284)6.29124313
8positive regulation of insulin receptor signaling pathway (GO:0046628)5.92244852
9nucleoside transport (GO:0015858)5.81378876
10regulation of guanylate cyclase activity (GO:0031282)5.71388980
11receptor guanylyl cyclase signaling pathway (GO:0007168)5.70956466
12neural tube formation (GO:0001841)5.19842669
13centriole assembly (GO:0098534)5.15023392
14positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.80414028
15respiratory system process (GO:0003016)4.66895302
16vesicle transport along microtubule (GO:0047496)4.59361065
17nucleotide transport (GO:0006862)4.56614776
18peptidyl-threonine dephosphorylation (GO:0035970)4.53033660
19dermatan sulfate biosynthetic process (GO:0030208)4.23466740
20regulation of clathrin-mediated endocytosis (GO:2000369)4.20244444
21gastrulation with mouth forming second (GO:0001702)4.17946331
22fibroblast migration (GO:0010761)4.07689725
23positive regulation of cGMP biosynthetic process (GO:0030828)3.94788072
24C4-dicarboxylate transport (GO:0015740)3.92827737
25negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.91333555
26positive regulation of mitochondrial fission (GO:0090141)3.88717138
27regulation of hippo signaling (GO:0035330)3.85864375
28dermatan sulfate metabolic process (GO:0030205)3.84457224
29histone H2A monoubiquitination (GO:0035518)3.79119654
30water-soluble vitamin biosynthetic process (GO:0042364)3.76274603
31regulation of cGMP biosynthetic process (GO:0030826)3.70657137
32positive regulation of receptor biosynthetic process (GO:0010870)3.70345824
33iron-sulfur cluster assembly (GO:0016226)3.68014091
34metallo-sulfur cluster assembly (GO:0031163)3.68014091
35negative regulation of gluconeogenesis (GO:0045721)3.64536183
36glial cell proliferation (GO:0014009)3.62103292
37limb bud formation (GO:0060174)3.56212515
38positive regulation of cellular response to insulin stimulus (GO:1900078)3.55289445
39mitochondrion transport along microtubule (GO:0047497)3.53161136
40establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.53161136
41positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.50360074
42face development (GO:0060324)3.49721306
43regulation of hydrogen peroxide metabolic process (GO:0010310)3.44117021
44L-amino acid import (GO:0043092)3.43501120
45positive regulation of cGMP metabolic process (GO:0030825)3.41497081
46establishment of mitochondrion localization (GO:0051654)3.37304746
47maintenance of protein location in nucleus (GO:0051457)3.35358805
48retinal cone cell development (GO:0046549)3.32409612
49regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.29438296
50cochlea development (GO:0090102)3.22915266
51microtubule anchoring (GO:0034453)3.22514302
52cullin deneddylation (GO:0010388)3.16710403
53regulation of chemokine-mediated signaling pathway (GO:0070099)3.09082818
54regulation of mesenchymal cell apoptotic process (GO:2001053)3.01954394
55regulation of cGMP metabolic process (GO:0030823)3.01533514
56synapse assembly (GO:0007416)3.00671521
57L-serine transport (GO:0015825)2.97574628
58deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96549816
59cornea development in camera-type eye (GO:0061303)2.92279685
60cytoplasmic mRNA processing body assembly (GO:0033962)2.91754641
61organelle transport along microtubule (GO:0072384)2.87515549
62histone H2A acetylation (GO:0043968)2.87468090
63galactose catabolic process (GO:0019388)2.86942077
64regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.85445435
65positive regulation of B cell differentiation (GO:0045579)2.85438268
66regulation of mitochondrial depolarization (GO:0051900)2.84169166
67axon extension (GO:0048675)2.83252008
68regulation of double-strand break repair via homologous recombination (GO:0010569)2.79474570
69protein deneddylation (GO:0000338)2.79207793
70cardiac ventricle formation (GO:0003211)2.78981505
71positive regulation of protein homodimerization activity (GO:0090073)2.76183431
72ionotropic glutamate receptor signaling pathway (GO:0035235)2.75866190
73protein localization to cilium (GO:0061512)2.75751384
74deoxyribonucleotide biosynthetic process (GO:0009263)2.74974450
75histone H2A ubiquitination (GO:0033522)2.74208184
76heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.73272905
77axonal fasciculation (GO:0007413)2.72476405
78histone monoubiquitination (GO:0010390)2.66805522
79regulation of interferon-beta biosynthetic process (GO:0045357)2.64060479
80reflex (GO:0060004)2.62864415
81somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61842080
82isotype switching (GO:0045190)2.61842080
83somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61842080
84regulation of helicase activity (GO:0051095)2.60259728
85neurotransmitter-gated ion channel clustering (GO:0072578)2.58031304
86gamma-aminobutyric acid signaling pathway (GO:0007214)2.57186524
87negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55231022
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55093047
89cardiac chamber formation (GO:0003207)2.54490714
90neuron recognition (GO:0008038)2.54320903
91positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.52049351
92polarized epithelial cell differentiation (GO:0030859)2.51593635
93lymphoid progenitor cell differentiation (GO:0002320)2.49709346
94serine transport (GO:0032329)2.47222885
95cilium or flagellum-dependent cell motility (GO:0001539)2.45248546
96regulation of female gonad development (GO:2000194)2.45056730
97short-term memory (GO:0007614)11.8857288
98peptidyl-arginine methylation (GO:0018216)11.4482483
99peptidyl-arginine N-methylation (GO:0035246)11.4482483
100head development (GO:0060322)10.9963557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.62128875
2IGF1R_20145208_ChIP-Seq_DFB_Human4.90902783
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.55822642
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons4.46215296
5EZH2_22144423_ChIP-Seq_EOC_Human4.43292663
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.34543129
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.58576787
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.36514273
9GBX2_23144817_ChIP-Seq_PC3_Human3.28865112
10ZNF274_21170338_ChIP-Seq_K562_Hela2.97575533
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71153960
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48086214
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46216638
14* ER_23166858_ChIP-Seq_MCF-7_Human2.18697439
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18581766
16TAF15_26573619_Chip-Seq_HEK293_Human2.10963792
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10569988
18MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse2.10476847
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96198718
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95509212
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89625519
22VDR_22108803_ChIP-Seq_LS180_Human1.84108634
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79384276
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71388497
25* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67461326
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64250335
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61775675
28FUS_26573619_Chip-Seq_HEK293_Human1.60162954
29SMAD4_21799915_ChIP-Seq_A2780_Human1.59623095
30RNF2_27304074_Chip-Seq_NSC_Mouse1.59191901
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57265875
32TAL1_26923725_Chip-Seq_HPCs_Mouse1.56197644
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54115111
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50480582
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50412811
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.45930025
37RUNX2_22187159_ChIP-Seq_PCA_Human1.43409787
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42627644
39* EWS_26573619_Chip-Seq_HEK293_Human1.41992293
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41306845
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41076683
42* STAT3_23295773_ChIP-Seq_U87_Human1.39252807
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38557064
44P300_19829295_ChIP-Seq_ESCs_Human1.35976610
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33068527
46AR_25329375_ChIP-Seq_VCAP_Human1.32364354
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31202322
48KDM2B_26808549_Chip-Seq_REH_Human1.26093782
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.24823620
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22460021
51REST_21632747_ChIP-Seq_MESCs_Mouse1.21892458
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.21798932
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20682796
54HTT_18923047_ChIP-ChIP_STHdh_Human1.19591302
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19545499
56* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17227101
57* CBP_20019798_ChIP-Seq_JUKART_Human1.17227101
58RXR_22108803_ChIP-Seq_LS180_Human1.16894018
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.14736787
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.13468928
61BCAT_22108803_ChIP-Seq_LS180_Human1.12227742
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.11527257
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10346541
64* TCF4_23295773_ChIP-Seq_U87_Human1.10028642
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09620482
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07563065
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06154135
68DROSHA_22980978_ChIP-Seq_HELA_Human1.05041041
69JUN_21703547_ChIP-Seq_K562_Human1.04943245
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.03377557
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03194924
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.00142143
73EGR1_19032775_ChIP-ChIP_M12_Human0.98934435
74TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96773035
75TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96230441
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96105968
77JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95218775
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95193818
79AHR_22903824_ChIP-Seq_MCF-7_Human0.94426490
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.93388943
81FLI1_21867929_ChIP-Seq_TH2_Mouse0.92013807
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.90542533
83P53_22387025_ChIP-Seq_ESCs_Mouse0.90385608
84* ARNT_22903824_ChIP-Seq_MCF-7_Human0.90356642
85NANOG_19829295_ChIP-Seq_ESCs_Human0.90305923
86SOX2_19829295_ChIP-Seq_ESCs_Human0.90305923
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89971247
88STAT1_17558387_ChIP-Seq_HELA_Human0.89918852
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.88627691
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86856560
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86693690
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.86693690
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86533643
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86474510
95EZH2_27304074_Chip-Seq_ESCs_Mouse0.86459299
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84961472
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83417643
98OCT4_20526341_ChIP-Seq_ESCs_Human0.82375552
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80675761
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80663217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph5.54551405
2MP0000049_abnormal_middle_ear4.05655742
3MP0001485_abnormal_pinna_reflex4.02051573
4MP0002249_abnormal_larynx_morphology3.23202716
5MP0001849_ear_inflammation3.03628696
6MP0003938_abnormal_ear_development2.85238800
7MP0002837_dystrophic_cardiac_calcinosis2.69535816
8MP0005423_abnormal_somatic_nervous2.36336954
9MP0003221_abnormal_cardiomyocyte_apopto2.29486178
10MP0002177_abnormal_outer_ear2.24131230
11MP0004859_abnormal_synaptic_plasticity2.21693508
12MP0000569_abnormal_digit_pigmentation2.18413862
13MP0002102_abnormal_ear_morphology11.9014262
14MP0003718_maternal_effect1.95312986
15MP0002736_abnormal_nociception_after1.81859496
16MP0002234_abnormal_pharynx_morphology1.76046653
17MP0001984_abnormal_olfaction1.72640593
18MP0003880_abnormal_central_pattern1.72357011
19MP0009697_abnormal_copulation1.68753394
20MP0008789_abnormal_olfactory_epithelium1.64632428
21MP0006292_abnormal_olfactory_placode1.58363294
22MP0002233_abnormal_nose_morphology1.55895359
23MP0005499_abnormal_olfactory_system1.53201694
24MP0005394_taste/olfaction_phenotype1.53201694
25MP0001188_hyperpigmentation1.44441809
26MP0005551_abnormal_eye_electrophysiolog1.42681884
27MP0002653_abnormal_ependyma_morphology1.40467376
28MP0002822_catalepsy1.39704702
29MP0002735_abnormal_chemical_nociception1.38998272
30MP0002697_abnormal_eye_size1.34442074
31MP0003937_abnormal_limbs/digits/tail_de1.33880622
32MP0000026_abnormal_inner_ear1.30196134
33MP0002098_abnormal_vibrissa_morphology1.30112713
34MP0000427_abnormal_hair_cycle1.29149903
35MP0001968_abnormal_touch/_nociception1.27399786
36MP0008058_abnormal_DNA_repair1.27070992
37MP0001486_abnormal_startle_reflex1.25874634
38MP0002272_abnormal_nervous_system1.24161676
39MP0004084_abnormal_cardiac_muscle1.19651826
40MP0009046_muscle_twitch1.18932916
41MP0004782_abnormal_surfactant_physiolog1.15670245
42MP0003252_abnormal_bile_duct1.06308617
43MP0003755_abnormal_palate_morphology1.05345981
44MP0001764_abnormal_homeostasis1.04375472
45MP0009745_abnormal_behavioral_response1.04352434
46MP0004134_abnormal_chest_morphology1.04191409
47MP0001963_abnormal_hearing_physiology0.98410956
48MP0002751_abnormal_autonomic_nervous0.97029351
49MP0000778_abnormal_nervous_system0.93279783
50MP0003828_pulmonary_edema0.92738923
51MP0002734_abnormal_mechanical_nocicepti0.89373476
52MP0002184_abnormal_innervation0.88203222
53MP0002064_seizures0.86342520
54MP0003283_abnormal_digestive_organ0.85229077
55MP0002928_abnormal_bile_duct0.82816360
56MP0003635_abnormal_synaptic_transmissio0.76046591
57MP0002111_abnormal_tail_morphology0.74204188
58MP0008961_abnormal_basal_metabolism0.72974472
59MP0002752_abnormal_somatic_nervous0.72736100
60MP0001286_abnormal_eye_development0.72119953
61MP0003183_abnormal_peptide_metabolism0.69030879
62MP0005367_renal/urinary_system_phenotyp0.65643083
63MP0000516_abnormal_urinary_system0.65643083
64MP0002116_abnormal_craniofacial_bone0.64074724
65MP0008775_abnormal_heart_ventricle0.63256906
66MP0002067_abnormal_sensory_capabilities0.61778363
67MP0004811_abnormal_neuron_physiology0.61569895
68MP0000955_abnormal_spinal_cord0.60829104
69MP0002572_abnormal_emotion/affect_behav0.58827019
70MP0004147_increased_porphyrin_level0.58362449
71MP0003861_abnormal_nervous_system0.58071697
72MP0004742_abnormal_vestibular_system0.57843225
73MP0005248_abnormal_Harderian_gland0.56994616
74MP0001293_anophthalmia0.56955353
75MP0005395_other_phenotype0.56614594
76MP0005646_abnormal_pituitary_gland0.54649219
77MP0002090_abnormal_vision0.54597811
78MP0002882_abnormal_neuron_morphology0.54502158
79MP0003878_abnormal_ear_physiology0.54135527
80MP0005377_hearing/vestibular/ear_phenot0.54135527
81MP0001970_abnormal_pain_threshold0.53408223
82MP0003935_abnormal_craniofacial_develop0.51182192
83MP0002063_abnormal_learning/memory/cond0.49609544
84MP0000678_abnormal_parathyroid_gland0.48751701
85MP0001191_abnormal_skin_condition0.48271298
86MP0004197_abnormal_fetal_growth/weight/0.48156954
87MP0004215_abnormal_myocardial_fiber0.47630802
88MP0008877_abnormal_DNA_methylation0.46612695
89MP0002152_abnormal_brain_morphology0.45147653
90MP0000631_abnormal_neuroendocrine_gland0.44886913
91MP0002084_abnormal_developmental_patter0.44051294
92MP0000681_abnormal_thyroid_gland0.43097030
93MP0001340_abnormal_eyelid_morphology0.42127402
94MP0002282_abnormal_trachea_morphology0.40449624
95MP0003950_abnormal_plasma_membrane0.39776825
96MP0002114_abnormal_axial_skeleton0.39200685
97MP0003119_abnormal_digestive_system0.38885566
98MP0003633_abnormal_nervous_system0.38457043
99MP0002229_neurodegeneration0.38364998
100MP0001324_abnormal_eye_pigmentation0.38195788

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)7.44230759
2Abnormality of the left ventricular outflow tract (HP:0011103)7.22029324
3Subaortic stenosis (HP:0001682)7.22029324
4Epidermoid cyst (HP:0200040)6.54595544
5Progressive inability to walk (HP:0002505)5.60462474
6Aqueductal stenosis (HP:0002410)4.88860307
7Mutism (HP:0002300)4.60907305
8Hepatoblastoma (HP:0002884)4.14380589
9Progressive cerebellar ataxia (HP:0002073)3.87132525
10Long clavicles (HP:0000890)3.75375056
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.74262199
12Gastrointestinal atresia (HP:0002589)3.52176486
13Abnormality of the labia minora (HP:0012880)3.35268746
14Inability to walk (HP:0002540)3.30969488
15Drooling (HP:0002307)3.28974433
16Long nose (HP:0003189)3.25444022
17Nephroblastoma (Wilms tumor) (HP:0002667)3.25353478
18Shoulder girdle muscle weakness (HP:0003547)3.19872748
19Abnormality of the labia majora (HP:0012881)3.19017500
20Agnosia (HP:0010524)3.10208433
21Excessive salivation (HP:0003781)3.08430038
22Growth hormone deficiency (HP:0000824)3.07533931
23Embryonal renal neoplasm (HP:0011794)3.06576955
24Chronic hepatic failure (HP:0100626)3.06235321
25Increased nuchal translucency (HP:0010880)3.02362509
26Sleep apnea (HP:0010535)2.98969266
27Abnormal lung lobation (HP:0002101)2.95448452
28Pelvic girdle muscle weakness (HP:0003749)2.94166055
29Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.93745578
30Short 1st metacarpal (HP:0010034)2.93745578
31Small intestinal stenosis (HP:0012848)2.88749660
32Duodenal stenosis (HP:0100867)2.88749660
33Embryonal neoplasm (HP:0002898)2.84446216
34Aortic regurgitation (HP:0001659)2.78913509
35Abnormal umbilical cord blood vessels (HP:0011403)2.76796410
36Single umbilical artery (HP:0001195)2.76796410
37Abnormality of the fetal cardiovascular system (HP:0010948)2.76796410
38Generalized tonic-clonic seizures (HP:0002069)2.63094746
39Abnormality of the 1st metacarpal (HP:0010009)2.59612430
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.56655314
41Hypoplastic nipples (HP:0002557)2.56557571
42Bile duct proliferation (HP:0001408)2.54691839
43Abnormal biliary tract physiology (HP:0012439)2.54691839
44Abnormality of the musculature of the pelvis (HP:0001469)2.52108892
45Abnormality of the hip-girdle musculature (HP:0001445)2.52108892
46Hypoplastic labia majora (HP:0000059)2.46791644
47Neoplasm of the colon (HP:0100273)2.43418447
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.37543019
49Hypoplasia of the fovea (HP:0007750)2.37543019
50Hyperglycinemia (HP:0002154)2.34593991
51Short palpebral fissure (HP:0012745)2.32638661
52Genetic anticipation (HP:0003743)2.30891119
53Sloping forehead (HP:0000340)2.29004254
54Nephronophthisis (HP:0000090)2.28928374
55Abnormality of the duodenum (HP:0002246)2.28068198
56Central scotoma (HP:0000603)2.26756507
57Popliteal pterygium (HP:0009756)2.26245203
58Fetal akinesia sequence (HP:0001989)2.25527091
59Increased density of long bones (HP:0006392)2.25417481
60Abnormality of the pubic bones (HP:0003172)2.18157876
61Facial hemangioma (HP:0000329)2.15391457
62Methylmalonic acidemia (HP:0002912)2.14458067
63Absent thumb (HP:0009777)2.12498116
64Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10608202
65Neonatal respiratory distress (HP:0002643)2.08962574
66Reduced antithrombin III activity (HP:0001976)2.08127966
67Widely patent fontanelles and sutures (HP:0004492)2.05587836
68Optic nerve hypoplasia (HP:0000609)2.02610652
69Intellectual disability, severe (HP:0010864)2.01767491
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.01371426
71Intestinal polyposis (HP:0200008)1.98248675
72Tubular atrophy (HP:0000092)1.97403136
73Absent radius (HP:0003974)1.97019423
74Proximal tubulopathy (HP:0000114)1.96213698
75Coarctation of aorta (HP:0001680)1.95131630
76Aplasia/Hypoplasia of the patella (HP:0006498)1.92534620
77Limb dystonia (HP:0002451)1.91867049
78Bowel incontinence (HP:0002607)1.90371432
79Disinhibition (HP:0000734)1.89361825
80Ependymoma (HP:0002888)1.85812392
81Short phalanx of the thumb (HP:0009660)1.85582948
82Aplasia involving forearm bones (HP:0009822)1.85389559
83Absent forearm bone (HP:0003953)1.85389559
84Urinary urgency (HP:0000012)1.84997622
85Labial hypoplasia (HP:0000066)1.84225788
86Truncal ataxia (HP:0002078)1.83458277
87Intestinal polyp (HP:0005266)1.81451563
88Abnormality of the renal medulla (HP:0100957)1.80942617
89Patellar aplasia (HP:0006443)1.80765467
90Abnormality of the fovea (HP:0000493)1.79515467
91Molar tooth sign on MRI (HP:0002419)1.75066910
92Abnormality of midbrain morphology (HP:0002418)1.75066910
93Progressive external ophthalmoplegia (HP:0000590)1.74706367
94Abnormal large intestine physiology (HP:0012700)1.74426367
95Aplasia/Hypoplasia of the nipples (HP:0006709)1.73184598
96Limb-girdle muscle atrophy (HP:0003797)1.73022103
97Epileptiform EEG discharges (HP:0011182)1.72122518
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.71599958
99Termporal pattern (HP:0011008)1.71348999
100Insidious onset (HP:0003587)1.71348999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR7.79584062
2TRIM285.91110068
3MINK15.20701879
4SIK35.16955544
5FRK3.00301767
6MAP3K92.70238100
7SRPK12.45439895
8RPS6KA41.97617606
9NTRK31.92520179
10MAPK131.86491642
11CSNK1A1L1.73798914
12KSR11.66942820
13CSNK1G31.63222893
14EPHA41.49272307
15MAP3K61.42729178
16ERBB31.41789100
17MAP3K71.39093023
18CSNK1G21.37830732
19CSNK1G11.29340163
20DYRK31.27564984
21NTRK21.26567490
22CASK1.24072917
23KDR1.16306350
24MAP3K41.16258816
25MARK11.11541197
26NEK61.07435814
27WNK31.05495168
28MAP2K71.03530015
29CCNB10.98869325
30VRK10.93955254
31MAP2K40.89550209
32CAMKK20.87669827
33PIK3CA0.86931164
34TNK20.82593540
35DYRK1B0.81557417
36OXSR10.79939178
37CAMK1D0.78536947
38FGFR20.74315189
39TBK10.73778281
40PKN20.72191713
41PLK30.70800015
42DYRK20.66098173
43TIE10.65854213
44PRKCE0.64972218
45PRKCI0.64329468
46CSNK1D0.64043468
47PRKG10.63352897
48INSRR0.63338768
49DAPK20.59854178
50BCKDK0.58581062
51CAMKK10.57659659
52PRKD30.56616469
53CAMK40.53983144
54GRK70.52678406
55DYRK1A0.52190252
56PAK60.51346882
57PRKCZ0.50833765
58FLT30.49460864
59CSNK1A10.48717198
60TLK10.48591920
61LATS10.48198696
62SGK4940.45952729
63SGK2230.45952729
64CDK180.44432131
65CSNK1E0.43926874
66SGK20.43691320
67PIM10.43245123
68RPS6KA50.42976427
69PRKACB0.41069198
70PRKCG0.39924391
71PRKD20.39386970
72LMTK20.39047703
73GRK10.38922382
74MOS0.38323269
75RPS6KB10.35594245
76STK390.34933693
77EGFR0.34440795
78CAMK1G0.34019113
79PAK30.33878355
80TAOK30.33203518
81CDK140.33160642
82CAMK2B0.32001926
83RPS6KA20.31741965
84HIPK20.31640015
85PRKD10.31081349
86CSF1R0.29353843
87CSNK2A20.28811519
88CSNK2A10.28553530
89YES10.27600963
90MET0.27218105
91RPS6KA30.27194794
92PKN10.27059956
93CDK50.26892933
94MAP3K100.26140226
95PLK20.25888209
96BMPR1B0.25588249
97PRKACA0.23215363
98EIF2AK10.23018344
99PRKCB0.22535321
100MAP3K120.22182855

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.62018315
2Nicotine addiction_Homo sapiens_hsa050333.48586588
3Basal transcription factors_Homo sapiens_hsa030223.35788708
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.84554661
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.58288820
6GABAergic synapse_Homo sapiens_hsa047272.53498218
7Morphine addiction_Homo sapiens_hsa050322.30255749
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24937011
9RNA polymerase_Homo sapiens_hsa030202.19679916
10Selenocompound metabolism_Homo sapiens_hsa004502.13783567
11Oocyte meiosis_Homo sapiens_hsa041141.97763975
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.86620515
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.77858268
14Fanconi anemia pathway_Homo sapiens_hsa034601.76031743
15Circadian entrainment_Homo sapiens_hsa047131.69651057
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68878284
17Renin-angiotensin system_Homo sapiens_hsa046141.68264189
18Taste transduction_Homo sapiens_hsa047421.63279171
19Glutamatergic synapse_Homo sapiens_hsa047241.60324562
20Cocaine addiction_Homo sapiens_hsa050301.53926022
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51731590
22Insulin secretion_Homo sapiens_hsa049111.49925799
23Cell cycle_Homo sapiens_hsa041101.35277258
24Dopaminergic synapse_Homo sapiens_hsa047281.33925735
25Long-term depression_Homo sapiens_hsa047301.32915596
26Amphetamine addiction_Homo sapiens_hsa050311.32742527
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32330041
28mRNA surveillance pathway_Homo sapiens_hsa030151.29532720
29Ovarian steroidogenesis_Homo sapiens_hsa049131.29436925
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28588646
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26682799
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23532491
33Olfactory transduction_Homo sapiens_hsa047401.22998584
34ABC transporters_Homo sapiens_hsa020101.21872819
35Gap junction_Homo sapiens_hsa045401.21070601
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11969836
37Serotonergic synapse_Homo sapiens_hsa047261.11803703
38Long-term potentiation_Homo sapiens_hsa047201.10496858
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07880536
40Renin secretion_Homo sapiens_hsa049241.07824301
41Steroid biosynthesis_Homo sapiens_hsa001001.07303569
42Salivary secretion_Homo sapiens_hsa049701.06997110
43Gastric acid secretion_Homo sapiens_hsa049711.03794713
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03668247
45Non-homologous end-joining_Homo sapiens_hsa034501.00015958
46Cardiac muscle contraction_Homo sapiens_hsa042600.99550017
47cAMP signaling pathway_Homo sapiens_hsa040240.99318913
48Histidine metabolism_Homo sapiens_hsa003400.94288020
49Inositol phosphate metabolism_Homo sapiens_hsa005620.93654655
50Nitrogen metabolism_Homo sapiens_hsa009100.92745697
51Butanoate metabolism_Homo sapiens_hsa006500.88538972
52RNA degradation_Homo sapiens_hsa030180.81725082
53Purine metabolism_Homo sapiens_hsa002300.79800846
54Pancreatic secretion_Homo sapiens_hsa049720.79303474
55Cholinergic synapse_Homo sapiens_hsa047250.78644546
56Hedgehog signaling pathway_Homo sapiens_hsa043400.78626011
57Spliceosome_Homo sapiens_hsa030400.78230681
58Axon guidance_Homo sapiens_hsa043600.76069523
59Herpes simplex infection_Homo sapiens_hsa051680.75840290
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73500997
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72790307
62Mismatch repair_Homo sapiens_hsa034300.70205307
63Calcium signaling pathway_Homo sapiens_hsa040200.68187803
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66990932
65Peroxisome_Homo sapiens_hsa041460.66305749
66Alcoholism_Homo sapiens_hsa050340.65701892
67Rap1 signaling pathway_Homo sapiens_hsa040150.65111411
68Fatty acid biosynthesis_Homo sapiens_hsa000610.63015188
69Starch and sucrose metabolism_Homo sapiens_hsa005000.63003370
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61193145
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.59236834
72Oxytocin signaling pathway_Homo sapiens_hsa049210.55442529
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55024595
74Thyroid hormone synthesis_Homo sapiens_hsa049180.54901872
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53787788
76Base excision repair_Homo sapiens_hsa034100.53182716
77mTOR signaling pathway_Homo sapiens_hsa041500.51797200
78Vitamin B6 metabolism_Homo sapiens_hsa007500.50579933
79Epstein-Barr virus infection_Homo sapiens_hsa051690.50297098
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50251235
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47924646
82Systemic lupus erythematosus_Homo sapiens_hsa053220.46311692
83Tight junction_Homo sapiens_hsa045300.44664010
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43949117
85Ras signaling pathway_Homo sapiens_hsa040140.42901554
86Pyrimidine metabolism_Homo sapiens_hsa002400.42300798
87Chemical carcinogenesis_Homo sapiens_hsa052040.41166765
88PPAR signaling pathway_Homo sapiens_hsa033200.40124047
89MAPK signaling pathway_Homo sapiens_hsa040100.39356676
90AMPK signaling pathway_Homo sapiens_hsa041520.38521112
91RNA transport_Homo sapiens_hsa030130.37958835
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37553436
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35024058
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.31367481
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30490977
96Arginine and proline metabolism_Homo sapiens_hsa003300.28799424
97Viral carcinogenesis_Homo sapiens_hsa052030.28722815
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27293878
99Protein digestion and absorption_Homo sapiens_hsa049740.27246527
100beta-Alanine metabolism_Homo sapiens_hsa004100.26898216

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