ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to synapse (GO:0035418)	7.11337043
2	intermediate filament organization (GO:0045109)	5.75192155
3	urinary tract smooth muscle contraction (GO:0014848)	4.89178653
4	acrosome reaction (GO:0007340)	4.59753696
5	iron-sulfur cluster assembly (GO:0016226)	4.59584171
6	metallo-sulfur cluster assembly (GO:0031163)	4.59584171
7	positive regulation of T cell differentiation in thymus (GO:0033089)	4.56580886
8	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	4.51348487
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.49790077
10	peristalsis (GO:0030432)	4.36100212
11	neuron cell-cell adhesion (GO:0007158)	4.34261224
12	spinal cord motor neuron differentiation (GO:0021522)	4.29857894
13	neuron fate determination (GO:0048664)	4.22180837
14	regulation of respiratory system process (GO:0044065)	4.11323138
15	histone H2B ubiquitination (GO:0033523)	4.10964392
16	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	4.03027714
17	cell fate commitment involved in formation of primary germ layer (GO:0060795)	4.01478332
18	positive regulation of histone H3-K4 methylation (GO:0051571)	4.00436127
19	histone H3-K4 trimethylation (GO:0080182)	3.95636537
20	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	3.93595017
21	fucose catabolic process (GO:0019317)	3.88973204
22	L-fucose metabolic process (GO:0042354)	3.88973204
23	L-fucose catabolic process (GO:0042355)	3.88973204
24	regulation of cell maturation (GO:1903429)	3.83179434
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.80534797
26	detection of light stimulus involved in visual perception (GO:0050908)	3.80534797
27	hindbrain development (GO:0030902)	3.79810298
28	protein prenylation (GO:0018342)	3.77993014
29	prenylation (GO:0097354)	3.77993014
30	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.76802890
31	central nervous system projection neuron axonogenesis (GO:0021952)	3.76177559
32	intermediate filament-based process (GO:0045103)	3.67640099
33	glycine transport (GO:0015816)	3.66278631
34	behavioral response to nicotine (GO:0035095)	3.65228254
35	intermediate filament cytoskeleton organization (GO:0045104)	3.65029543
36	positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)	3.62736865
37	positive regulation of cell cycle G2/M phase transition (GO:1902751)	3.62736865
38	positive regulation of neurological system process (GO:0031646)	3.61555278
39	regulation of respiratory gaseous exchange (GO:0043576)	3.58740043
40	protein localization to microtubule cytoskeleton (GO:0072698)	3.57900067
41	startle response (GO:0001964)	3.57002018
42	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.56154701
43	endothelial cell chemotaxis (GO:0035767)	3.55879865
44	histone-serine phosphorylation (GO:0035404)	3.55851600
45	dopamine biosynthetic process (GO:0042416)	3.51969422
46	spermatid nucleus differentiation (GO:0007289)	3.51707184
47	myelin assembly (GO:0032288)	3.49771758
48	presynaptic membrane assembly (GO:0097105)	3.39936144
49	translesion synthesis (GO:0019985)	3.36981695
50	neuron fate specification (GO:0048665)	3.36749000
51	postsynaptic membrane organization (GO:0001941)	3.32009985
52	activated T cell proliferation (GO:0050798)	3.31186339
53	chemosensory behavior (GO:0007635)	3.29819119
54	negative regulation of astrocyte differentiation (GO:0048712)	3.29560716
55	neuromuscular synaptic transmission (GO:0007274)	3.27521666
56	positive regulation of microtubule polymerization (GO:0031116)	3.26835753
57	central nervous system neuron axonogenesis (GO:0021955)	3.25888864
58	epithelial cell maturation (GO:0002070)	3.25303673
59	centrosome localization (GO:0051642)	3.24942954
60	synaptic transmission, cholinergic (GO:0007271)	3.24237545
61	sensory perception of taste (GO:0050909)	3.23899282
62	response to insecticide (GO:0017085)	3.22521817
63	regulation of gamma-delta T cell differentiation (GO:0045586)	3.22413303
64	behavioral response to cocaine (GO:0048148)	3.14784149
65	pseudouridine synthesis (GO:0001522)	3.13990417
66	DNA deamination (GO:0045006)	3.11745802
67	spliceosomal complex assembly (GO:0000245)	3.09983613
68	regulation of timing of cell differentiation (GO:0048505)	3.07852389
69	forebrain neuron differentiation (GO:0021879)	3.07728126
70	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.06738835
71	maternal behavior (GO:0042711)	3.05908893
72	synaptic transmission, dopaminergic (GO:0001963)	3.05459701
73	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.04802056
74	thalamus development (GO:0021794)	3.03637266
75	single strand break repair (GO:0000012)	3.01347742
76	protein localization to cytoskeleton (GO:0044380)	3.01164364
77	regulation of spindle organization (GO:0090224)	3.00306235
78	positive regulation of histone methylation (GO:0031062)	2.99709287
79	positive regulation of synapse assembly (GO:0051965)	2.96859246
80	midbrain development (GO:0030901)	2.95976807
81	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.95664733
82	regulation of acrosome reaction (GO:0060046)	2.95184320
83	peptidyl-lysine trimethylation (GO:0018023)	2.95100403
84	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	2.93089698
85	cellular response to gonadotropin stimulus (GO:0071371)	2.91901136
86	regulation of oligodendrocyte differentiation (GO:0048713)	2.91737212
87	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.91608981
88	neuron projection extension (GO:1990138)	2.90280028
89	response to gonadotropin (GO:0034698)	2.89117068
90	negative regulation of inclusion body assembly (GO:0090084)	2.89082556
91	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.88924987
92	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.85594939
93	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.85529996
94	phasic smooth muscle contraction (GO:0014821)	2.84793351
95	cell differentiation in spinal cord (GO:0021515)	2.83342948
96	peripheral nervous system development (GO:0007422)	2.81537981
97	exploration behavior (GO:0035640)	2.80579085
98	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	2.80429986
99	regulation of development, heterochronic (GO:0040034)	2.80400718
100	intracellular protein transmembrane import (GO:0044743)	2.74281370

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.86577479
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.72265296
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.62846861
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.56629416
5	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.81849909
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.65788506
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.65701883
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.62305197
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.42977531
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.38369548
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32906086
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.27646634
13	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.26366436
14	FUS_26573619_Chip-Seq_HEK293_Human	2.24831328
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15391675
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.06731741
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.06113906
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.05040643
19	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.90219967
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84245722
21	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.82160248
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.80836127
23	P300_19829295_ChIP-Seq_ESCs_Human	1.80641093
24	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.75698210
25	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.74162586
26	VDR_22108803_ChIP-Seq_LS180_Human	1.66741739
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.66262888
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65856308
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.65134288
30	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62795609
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62645633
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.59825799
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57889348
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57889348
35	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.53061237
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.51385641
37	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.49574939
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.47761254
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47379684
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46053434
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.46053434
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45167054
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45074653
44	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.44857418
45	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.44648130
46	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.44648130
47	EWS_26573619_Chip-Seq_HEK293_Human	1.42171298
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.39810007
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39654715
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38615396
51	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.37836953
52	DROSHA_22980978_ChIP-Seq_HELA_Human	1.37765144
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37165094
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36508115
55	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.33455022
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29238928
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.29212356
58	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.28903395
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.27578780
60	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25223986
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.21614282
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19672404
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19365506
64	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.18769791
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17778782
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.15351405
67	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.14942380
68	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13990829
69	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.12817433
70	STAT3_23295773_ChIP-Seq_U87_Human	1.11253334
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10272537
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09526509
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08763314
74	SCL_19346495_ChIP-Seq_HPC-7_Human	1.07843759
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07593283
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07462513
77	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07403422
78	TCF4_23295773_ChIP-Seq_U87_Human	1.06561977
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06458881
80	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.06298402
81	BCAT_22108803_ChIP-Seq_LS180_Human	1.05769840
82	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03253397
83	RXR_22108803_ChIP-Seq_LS180_Human	1.02667797
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02133392
85	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.01131682
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00519553
87	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00519553
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99479260
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.97293394
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97203948
91	TBL1_22424771_ChIP-Seq_293T_Human	0.97105312
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96753976
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93760638
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.93694143
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.92642017
96	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.91387978
97	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.91363245
98	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.90879140
99	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.90675725
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.89902634

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	7.66212950
2	MP0000569_abnormal_digit_pigmentation	7.15596591
3	MP0000566_synostosis	4.05045226
4	MP0003880_abnormal_central_pattern	3.39311134
5	MP0006276_abnormal_autonomic_nervous	3.29080234
6	MP0002735_abnormal_chemical_nociception	3.00102053
7	MP0004885_abnormal_endolymph	2.96064846
8	MP0002102_abnormal_ear_morphology	2.41576593
9	MP0003183_abnormal_peptide_metabolism	2.33862652
10	MP0003693_abnormal_embryo_hatching	2.21660467
11	MP0004742_abnormal_vestibular_system	2.08406377
12	MP0009379_abnormal_foot_pigmentation	1.88468911
13	MP0006072_abnormal_retinal_apoptosis	1.85080729
14	MP0001968_abnormal_touch/_nociception	1.78044684
15	MP0008057_abnormal_DNA_replication	1.66428057
16	MP0009780_abnormal_chondrocyte_physiolo	1.66130442
17	MP0001188_hyperpigmentation	1.63782941
18	MP0003195_calcinosis	1.61811347
19	MP0002572_abnormal_emotion/affect_behav	1.57874801
20	MP0008875_abnormal_xenobiotic_pharmacok	1.56467092
21	MP0000049_abnormal_middle_ear	1.56222524
22	MP0009046_muscle_twitch	1.48992324
23	MP0003283_abnormal_digestive_organ	1.47968164
24	MP0000026_abnormal_inner_ear	1.37586357
25	MP0002063_abnormal_learning/memory/cond	1.34558517
26	MP0003646_muscle_fatigue	1.34422202
27	MP0001486_abnormal_startle_reflex	1.33114777
28	MP0003635_abnormal_synaptic_transmissio	1.32772644
29	MP0005551_abnormal_eye_electrophysiolog	1.31676735
30	MP0002272_abnormal_nervous_system	1.30646134
31	MP0001905_abnormal_dopamine_level	1.28754655
32	MP0003567_abnormal_fetal_cardiomyocyte	1.27832698
33	MP0004924_abnormal_behavior	1.26594128
34	MP0005386_behavior/neurological_phenoty	1.26594128
35	MP0002067_abnormal_sensory_capabilities	1.24668972
36	MP0001986_abnormal_taste_sensitivity	1.20471988
37	MP0009745_abnormal_behavioral_response	1.20389769
38	MP0001970_abnormal_pain_threshold	1.18728284
39	MP0001963_abnormal_hearing_physiology	1.17723065
40	MP0002733_abnormal_thermal_nociception	1.17529127
41	MP0005646_abnormal_pituitary_gland	1.17219566
42	MP0000778_abnormal_nervous_system	1.17153560
43	MP0003878_abnormal_ear_physiology	1.14078378
44	MP0005377_hearing/vestibular/ear_phenot	1.14078378
45	MP0002184_abnormal_innervation	1.13797530
46	MP0002095_abnormal_skin_pigmentation	1.11295976
47	MP0002168_other_aberrant_phenotype	1.09594733
48	MP0005174_abnormal_tail_pigmentation	1.08314739
49	MP0005499_abnormal_olfactory_system	1.05588054
50	MP0005394_taste/olfaction_phenotype	1.05588054
51	MP0008789_abnormal_olfactory_epithelium	1.02632004
52	MP0002557_abnormal_social/conspecific_i	1.02565728
53	MP0004142_abnormal_muscle_tone	0.99311052
54	MP0002229_neurodegeneration	0.98914144
55	MP0008877_abnormal_DNA_methylation	0.98380105
56	MP0002234_abnormal_pharynx_morphology	0.97869628
57	MP0002064_seizures	0.97784641
58	MP0002752_abnormal_somatic_nervous	0.95101656
59	MP0003937_abnormal_limbs/digits/tail_de	0.94800279
60	MP0008961_abnormal_basal_metabolism	0.94511132
61	MP0001440_abnormal_grooming_behavior	0.94129629
62	MP0000955_abnormal_spinal_cord	0.94011904
63	MP0004133_heterotaxia	0.93541992
64	MP0003137_abnormal_impulse_conducting	0.93459988
65	MP0001485_abnormal_pinna_reflex	0.90082478
66	MP0000428_abnormal_craniofacial_morphol	0.89782625
67	MP0003045_fibrosis	0.88993036
68	MP0002736_abnormal_nociception_after	0.88619855
69	MP0002653_abnormal_ependyma_morphology	0.88096982
70	MP0001324_abnormal_eye_pigmentation	0.87079779
71	MP0005410_abnormal_fertilization	0.87074058
72	MP0008569_lethality_at_weaning	0.85979750
73	MP0002751_abnormal_autonomic_nervous	0.85906301
74	MP0002882_abnormal_neuron_morphology	0.84925132
75	MP0002822_catalepsy	0.84518807
76	MP0005253_abnormal_eye_physiology	0.83107630
77	MP0008872_abnormal_physiological_respon	0.81783240
78	MP0004270_analgesia	0.80285907
79	MP0002277_abnormal_respiratory_mucosa	0.75645421
80	MP0003698_abnormal_male_reproductive	0.75379069
81	MP0000537_abnormal_urethra_morphology	0.74936401
82	MP0003136_yellow_coat_color	0.74080881
83	MP0005195_abnormal_posterior_eye	0.73778180
84	MP0003950_abnormal_plasma_membrane	0.73221208
85	MP0000534_abnormal_ureter_morphology	0.72852487
86	MP0003122_maternal_imprinting	0.70642191
87	MP0000631_abnormal_neuroendocrine_gland	0.70255236
88	MP0001929_abnormal_gametogenesis	0.68401032
89	MP0003119_abnormal_digestive_system	0.68111780
90	MP0002066_abnormal_motor_capabilities/c	0.67728609
91	MP0000383_abnormal_hair_follicle	0.66691082
92	MP0001944_abnormal_pancreas_morphology	0.65944215
93	MP0002734_abnormal_mechanical_nocicepti	0.65235466
94	MP0001765_abnormal_ion_homeostasis	0.63865858
95	MP0005187_abnormal_penis_morphology	0.63086284
96	MP0002109_abnormal_limb_morphology	0.61680334
97	MP0002938_white_spotting	0.60970577
98	MP0003638_abnormal_response/metabolism_	0.58772085
99	MP0002160_abnormal_reproductive_system	0.58538739
100	MP0001756_abnormal_urination	0.58150392

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	7.94614048
2	True hermaphroditism (HP:0010459)	4.74726690
3	Limb dystonia (HP:0002451)	4.27102418
4	Pancreatic fibrosis (HP:0100732)	3.90047733
5	Palmar hyperkeratosis (HP:0010765)	3.76434617
6	Abnormality of the renal collecting system (HP:0004742)	3.76335878
7	Hypoplastic ischia (HP:0003175)	3.74366592
8	Duplicated collecting system (HP:0000081)	3.64609730
9	Pancreatic cysts (HP:0001737)	3.58191496
10	Palmoplantar hyperkeratosis (HP:0000972)	3.56336033
11	Febrile seizures (HP:0002373)	3.47403213
12	Abnormality of the ischium (HP:0003174)	3.26923179
13	Molar tooth sign on MRI (HP:0002419)	3.24603440
14	Abnormality of midbrain morphology (HP:0002418)	3.24603440
15	Constricted visual fields (HP:0001133)	3.03961104
16	Reticulocytopenia (HP:0001896)	3.01586239
17	Congenital stationary night blindness (HP:0007642)	2.92657245
18	Truncal obesity (HP:0001956)	2.90000285
19	Pendular nystagmus (HP:0012043)	2.85988977
20	Global brain atrophy (HP:0002283)	2.84228821
21	Cystic liver disease (HP:0006706)	2.78023200
22	Nephronophthisis (HP:0000090)	2.77745968
23	Progressive inability to walk (HP:0002505)	2.77269289
24	Vacuolated lymphocytes (HP:0001922)	2.73403647
25	Plantar hyperkeratosis (HP:0007556)	2.71799634
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.70329102
27	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.69004482
28	Absent/shortened dynein arms (HP:0200106)	2.63964479
29	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.63964479
30	Furrowed tongue (HP:0000221)	2.61779523
31	Decreased central vision (HP:0007663)	2.57829010
32	Abolished electroretinogram (ERG) (HP:0000550)	2.56470425
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.54635516
34	Sclerocornea (HP:0000647)	2.50990521
35	Ulnar claw (HP:0001178)	2.47888530
36	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.47320385
37	Depressed nasal tip (HP:0000437)	2.45743285
38	Hypoplastic labia majora (HP:0000059)	2.45563234
39	Acute lymphatic leukemia (HP:0006721)	2.31891511
40	Volvulus (HP:0002580)	2.28580050
41	Severe global developmental delay (HP:0011344)	2.27952122
42	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.27169133
43	Postaxial foot polydactyly (HP:0001830)	2.27128124
44	Anencephaly (HP:0002323)	2.26637852
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.26398516
46	Birth length less than 3rd percentile (HP:0003561)	2.26170683
47	Confusion (HP:0001289)	2.25238203
48	Abnormality of the labia majora (HP:0012881)	2.22050674
49	Abnormality of pyrimidine metabolism (HP:0004353)	2.21187244
50	Hemiparesis (HP:0001269)	2.18670741
51	Ectopic kidney (HP:0000086)	2.18474672
52	Chromsome breakage (HP:0040012)	2.18239550
53	Abnormality of the renal medulla (HP:0100957)	2.18057916
54	Genetic anticipation (HP:0003743)	2.16792223
55	Congenital hepatic fibrosis (HP:0002612)	2.16677696
56	Abnormality of the labia minora (HP:0012880)	2.13180138
57	Morphological abnormality of the pyramidal tract (HP:0002062)	2.09929957
58	Dry hair (HP:0011359)	2.07706848
59	Esotropia (HP:0000565)	2.07681426
60	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.07547991
61	Macular degeneration (HP:0000608)	2.05904863
62	Abnormal number of incisors (HP:0011064)	2.02831656
63	Bony spicule pigmentary retinopathy (HP:0007737)	2.01731431
64	Cystic hygroma (HP:0000476)	1.98306293
65	Progressive visual loss (HP:0000529)	1.96377125
66	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.94713957
67	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.94713957
68	Wrist flexion contracture (HP:0001239)	1.93876006
69	Impaired smooth pursuit (HP:0007772)	1.93642564
70	Medial flaring of the eyebrow (HP:0010747)	1.92867580
71	Optic nerve coloboma (HP:0000588)	1.92468592
72	Rib fusion (HP:0000902)	1.91446067
73	Hyperkalemia (HP:0002153)	1.91344208
74	Specific learning disability (HP:0001328)	1.90266439
75	Hyperglycinuria (HP:0003108)	1.86484583
76	Bifid tongue (HP:0010297)	1.86456674
77	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.84826758
78	Abnormal biliary tract physiology (HP:0012439)	1.82882618
79	Bile duct proliferation (HP:0001408)	1.82882618
80	Gait imbalance (HP:0002141)	1.82333208
81	Male pseudohermaphroditism (HP:0000037)	1.82148014
82	Pachygyria (HP:0001302)	1.81776300
83	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.80765315
84	Hypoplastic scapulae (HP:0000882)	1.80765315
85	Lissencephaly (HP:0001339)	1.79410586
86	Partial agenesis of the corpus callosum (HP:0001338)	1.79046692
87	Optic nerve hypoplasia (HP:0000609)	1.78203889
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76310504
89	Abnormal respiratory epithelium morphology (HP:0012253)	1.76310504
90	Nonprogressive disorder (HP:0003680)	1.75214464
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74141247
92	Diplopia (HP:0000651)	1.73400372
93	Abnormality of binocular vision (HP:0011514)	1.73400372
94	Morphological abnormality of the inner ear (HP:0011390)	1.72721773
95	Medulloblastoma (HP:0002885)	1.72635909
96	Synostosis involving the elbow (HP:0003938)	1.70023220
97	Humeroradial synostosis (HP:0003041)	1.70023220
98	Optic disc pallor (HP:0000543)	1.69844053
99	Hyperactive renin-angiotensin system (HP:0000841)	1.69707582
100	Decreased circulating renin level (HP:0003351)	1.69648700

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	7.04467087
2	PNCK	6.71223517
3	TAF1	4.32773144
4	MARK1	4.30130726
5	TAOK3	3.20271528
6	CASK	3.15542296
7	TNIK	3.09987927
8	GRK1	3.03677419
9	NTRK2	2.87524528
10	NTRK3	2.52249249
11	TSSK6	2.23075896
12	ADRBK2	2.11251352
13	WEE1	1.98793242
14	VRK1	1.91794187
15	MAPK15	1.74406226
16	MAP4K2	1.71816971
17	ERBB3	1.70235306
18	BMPR1B	1.68949202
19	MAPKAPK5	1.51418965
20	DDR2	1.14525511
21	LATS1	1.11513046
22	MAP3K4	1.07186431
23	MUSK	1.00513975
24	PBK	0.94937588
25	ACVR1B	0.93613316
26	SRPK1	0.93127524
27	PIK3CG	0.91438692
28	ERBB4	0.91366397
29	CLK1	0.87291903
30	PINK1	0.84359238
31	FGFR3	0.81631705
32	TLK1	0.79700041
33	PLK4	0.79208866
34	VRK2	0.78180605
35	BRSK2	0.76148940
36	PRKCG	0.75961289
37	MAPK13	0.74133900
38	FRK	0.68375706
39	TYRO3	0.66361322
40	PHKG1	0.59957670
41	PHKG2	0.59957670
42	SGK2	0.57977368
43	WNK3	0.56184987
44	AURKA	0.55321619
45	UHMK1	0.51947637
46	SGK223	0.51481562
47	SGK494	0.51481562
48	RPS6KA6	0.50268700
49	CHEK2	0.47363811
50	NUAK1	0.47113766
51	CSNK1G2	0.46828843
52	DYRK2	0.45686849
53	CSNK1G1	0.45321076
54	CSNK1G3	0.44652777
55	DYRK1A	0.43776479
56	INSRR	0.43086069
57	GRK5	0.42620277
58	PLK3	0.42421747
59	ADRBK1	0.41065700
60	TGFBR1	0.40493430
61	STK16	0.40482727
62	CSNK1A1L	0.40047724
63	NEK9	0.39891111
64	MATK	0.37917395
65	TESK2	0.37056236
66	RPS6KL1	0.36680077
67	RPS6KC1	0.36680077
68	RPS6KA5	0.32944517
69	BCKDK	0.31721845
70	MAP2K1	0.31055276
71	TXK	0.31023407
72	MAP2K7	0.29574909
73	CAMK2A	0.29561890
74	PRKG1	0.29313497
75	TRIM28	0.28817724
76	CDK5	0.28718703
77	RPS6KB1	0.26062043
78	RPS6KA1	0.25372269
79	KSR2	0.25027147
80	PKN1	0.24824680
81	ARAF	0.23041948
82	SYK	0.22716034
83	PRKACA	0.21856476
84	CSNK1A1	0.20813785
85	MAP2K4	0.20731877
86	MKNK2	0.20200122
87	LIMK1	0.19772463
88	MKNK1	0.19576945
89	TEC	0.19532138
90	PRKACB	0.18731215
91	AURKB	0.17588604
92	CAMK2B	0.17394372
93	CDK3	0.17273772
94	PRKCE	0.16241794
95	OBSCN	0.15171504
96	MAPK4	0.14845982
97	RPS6KA2	0.14624973
98	PTK2B	0.13895633
99	CHUK	0.13074767
100	KSR1	0.11750350

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.14763919
2	Taste transduction_Homo sapiens_hsa04742	3.40543772
3	Basal transcription factors_Homo sapiens_hsa03022	3.07546495
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.74488445
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.73252467
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.37109175
7	Nicotine addiction_Homo sapiens_hsa05033	2.32754111
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.32711166
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.27842950
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00757236
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.00284692
12	Butanoate metabolism_Homo sapiens_hsa00650	1.94958696
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.87916013
14	Phototransduction_Homo sapiens_hsa04744	1.86409038
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.74372713
16	Histidine metabolism_Homo sapiens_hsa00340	1.69696822
17	Basal cell carcinoma_Homo sapiens_hsa05217	1.65953450
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62164354
19	Serotonergic synapse_Homo sapiens_hsa04726	1.61471092
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60961805
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.57377230
22	Propanoate metabolism_Homo sapiens_hsa00640	1.51946642
23	Cocaine addiction_Homo sapiens_hsa05030	1.51766333
24	Olfactory transduction_Homo sapiens_hsa04740	1.51004711
25	One carbon pool by folate_Homo sapiens_hsa00670	1.49172838
26	GABAergic synapse_Homo sapiens_hsa04727	1.48697459
27	Circadian entrainment_Homo sapiens_hsa04713	1.36322434
28	Amphetamine addiction_Homo sapiens_hsa05031	1.25363801
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.24032516
30	Morphine addiction_Homo sapiens_hsa05032	1.19308684
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.14006365
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10572996
33	Renin secretion_Homo sapiens_hsa04924	1.08896834
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.07216713
35	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.06479335
36	Calcium signaling pathway_Homo sapiens_hsa04020	1.04776582
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04251603
38	Oocyte meiosis_Homo sapiens_hsa04114	1.03435517
39	Alcoholism_Homo sapiens_hsa05034	1.03123078
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.01496381
41	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00100468
42	Cholinergic synapse_Homo sapiens_hsa04725	0.98965068
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.97982623
44	Salivary secretion_Homo sapiens_hsa04970	0.97458767
45	Ribosome_Homo sapiens_hsa03010	0.96340805
46	Dopaminergic synapse_Homo sapiens_hsa04728	0.96058157
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91546710
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.83463047
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.82622704
50	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.79915806
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75216134
52	Prion diseases_Homo sapiens_hsa05020	0.73981557
53	Long-term depression_Homo sapiens_hsa04730	0.71990513
54	Wnt signaling pathway_Homo sapiens_hsa04310	0.71514693
55	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.71375024
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.70986498
57	Estrogen signaling pathway_Homo sapiens_hsa04915	0.70834581
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67491886
59	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.67373497
60	Antigen processing and presentation_Homo sapiens_hsa04612	0.66781453
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.65330426
62	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64633373
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63836704
64	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.63134112
65	Bile secretion_Homo sapiens_hsa04976	0.62662153
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.62303205
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61339903
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60964164
69	Insulin secretion_Homo sapiens_hsa04911	0.60233649
70	Axon guidance_Homo sapiens_hsa04360	0.58960934
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58848680
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56670722
73	Melanogenesis_Homo sapiens_hsa04916	0.54770341
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.54183807
75	MAPK signaling pathway_Homo sapiens_hsa04010	0.53273009
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.49938853
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.49484151
78	Peroxisome_Homo sapiens_hsa04146	0.49444799
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.49217734
80	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.49104759
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46035025
82	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.45077290
83	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.44951677
84	Retinol metabolism_Homo sapiens_hsa00830	0.44349800
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44156079
86	Gastric acid secretion_Homo sapiens_hsa04971	0.41973753
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41037230
88	Oxidative phosphorylation_Homo sapiens_hsa00190	0.40322898
89	Huntingtons disease_Homo sapiens_hsa05016	0.39237674
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.35365168
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33547612
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.33247423
93	Circadian rhythm_Homo sapiens_hsa04710	0.32771579
94	Parkinsons disease_Homo sapiens_hsa05012	0.32415709
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.32012975
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.31527552
97	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.30236326
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29657272
99	Legionellosis_Homo sapiens_hsa05134	0.29274904
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27681570

ZNF807

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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