ZNF81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause mental retardation X-linked type 45 (MRX45). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cell size (GO:0045793)5.50386156
2negative regulation of neurotransmitter transport (GO:0051589)5.40053190
3positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)5.26185325
4negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.73144949
5negative regulation of calcium ion transport into cytosol (GO:0010523)4.67372759
6histone H3-K4 methylation (GO:0051568)4.44092089
7response to lipoprotein particle (GO:0055094)4.39474078
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.26459330
9cytoplasmic mRNA processing body assembly (GO:0033962)4.20423643
10nerve growth factor signaling pathway (GO:0038180)4.14694169
11regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.94390344
12negative regulation of vascular permeability (GO:0043116)3.90586857
13establishment of protein localization to Golgi (GO:0072600)3.89833522
14positive regulation of gamma-delta T cell activation (GO:0046645)3.86915686
15positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.79345747
16cellular extravasation (GO:0045123)3.74832216
17retrograde transport, vesicle recycling within Golgi (GO:0000301)3.70952479
18protein targeting to Golgi (GO:0000042)3.66793861
19neural tube formation (GO:0001841)3.65720517
20cellular response to exogenous dsRNA (GO:0071360)3.61685984
21regulation of mRNA catabolic process (GO:0061013)3.53119174
22DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.40964152
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40546439
24negative regulation of neurotransmitter secretion (GO:0046929)3.40131815
25positive regulation of mRNA catabolic process (GO:0061014)3.34068498
26regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.31794496
27negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.31056242
28chromatin silencing (GO:0006342)3.27802579
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25284727
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.25284727
31modulation by symbiont of host immune response (GO:0052553)3.25284727
32positive regulation by symbiont of host defense response (GO:0052509)3.25284727
33modulation by symbiont of host defense response (GO:0052031)3.25284727
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25284727
35cellular response to ethanol (GO:0071361)3.23910875
36monoubiquitinated protein deubiquitination (GO:0035520)3.21243317
37arginine catabolic process (GO:0006527)3.17777070
38response to host immune response (GO:0052572)3.17275843
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17275843
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.16506834
41interkinetic nuclear migration (GO:0022027)3.14752206
42positive regulation of granulocyte differentiation (GO:0030854)3.11784071
43regulation of B cell receptor signaling pathway (GO:0050855)3.11480058
44regulation of gamma-delta T cell differentiation (GO:0045586)3.05952521
45histone lysine methylation (GO:0034968)3.03699836
46diaphragm development (GO:0060539)3.01491656
473-UTR-mediated mRNA stabilization (GO:0070935)3.01058447
48B cell receptor signaling pathway (GO:0050853)3.00405154
49histone H3-K4 trimethylation (GO:0080182)2.96695436
50regulation of gamma-delta T cell activation (GO:0046643)2.93974004
51negative regulation of T-helper cell differentiation (GO:0045623)2.92280229
52negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92280229
53mitotic sister chromatid cohesion (GO:0007064)2.90561921
54DNA damage response, signal transduction resulting in transcription (GO:0042772)2.88471251
55reciprocal DNA recombination (GO:0035825)2.87325677
56reciprocal meiotic recombination (GO:0007131)2.87325677
57interferon-gamma production (GO:0032609)2.82953516
58determination of adult lifespan (GO:0008340)2.80484971
59nuclear pore complex assembly (GO:0051292)2.80358274
60N-terminal protein amino acid acetylation (GO:0006474)2.80124111
61regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.79276907
62pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.79213583
63UMP biosynthetic process (GO:0006222)2.79213583
64pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.79213583
65UMP metabolic process (GO:0046049)2.79213583
66negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.77773426
67microglial cell activation (GO:0001774)2.77322921
68positive regulation of signal transduction by p53 class mediator (GO:1901798)2.76805305
69regulation of memory T cell differentiation (GO:0043380)2.75245509
70hepatocyte apoptotic process (GO:0097284)2.74030076
71response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72015185
72response to host (GO:0075136)2.72015185
73response to host defenses (GO:0052200)2.72015185
74cellular protein complex localization (GO:0034629)2.71141561
75negative regulation of gene expression, epigenetic (GO:0045814)2.70703397
76histone H3-K9 methylation (GO:0051567)2.68431957
77exogenous drug catabolic process (GO:0042738)2.66994292
78protein prenylation (GO:0018342)2.65541472
79prenylation (GO:0097354)2.65541472
80regulation of MHC class II biosynthetic process (GO:0045346)2.63747090
81negative regulation of protein oligomerization (GO:0032460)2.61870282
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61548115
83negative regulation of translation, ncRNA-mediated (GO:0040033)2.61548115
84regulation of translation, ncRNA-mediated (GO:0045974)2.61548115
85parental behavior (GO:0060746)2.59822175
86positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59159559
87negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.58444959
88protein localization to Golgi apparatus (GO:0034067)2.58209313
89histone H3-K9 modification (GO:0061647)2.57896558
90drug catabolic process (GO:0042737)2.56454913
91negative regulation of macrophage differentiation (GO:0045650)2.55931874
92hypotonic response (GO:0006971)2.55269193
93peptidyl-threonine dephosphorylation (GO:0035970)2.54581632
94detection of molecule of bacterial origin (GO:0032490)2.52711760
95response to interleukin-15 (GO:0070672)2.52133774
96positive T cell selection (GO:0043368)2.51994767
97nuclear pore organization (GO:0006999)2.51465099
98pyrimidine nucleoside salvage (GO:0043097)2.51205546
99pyrimidine-containing compound salvage (GO:0008655)2.51205546
100regulation of granulocyte differentiation (GO:0030852)2.51174736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.58522102
2EZH2_22144423_ChIP-Seq_EOC_Human3.76456802
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.25989169
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74295752
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66581003
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55718269
7GATA1_22025678_ChIP-Seq_K562_Human2.48032133
8RUNX_20019798_ChIP-Seq_JUKART_Human2.34193914
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.31348449
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.30787335
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24145404
12IGF1R_20145208_ChIP-Seq_DFB_Human2.21473490
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.17521916
14GBX2_23144817_ChIP-Seq_PC3_Human2.04244672
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03892350
16SCL_19346495_ChIP-Seq_HPC-7_Human2.00369305
17TAF15_26573619_Chip-Seq_HEK293_Human1.96944440
18TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.92958569
19FUS_26573619_Chip-Seq_HEK293_Human1.87547672
20TP53_16413492_ChIP-PET_HCT116_Human1.74546264
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71501749
22STAT3_23295773_ChIP-Seq_U87_Human1.68129688
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67148884
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66427658
25* ZNF274_21170338_ChIP-Seq_K562_Hela1.64141185
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.59722299
27EWS_26573619_Chip-Seq_HEK293_Human1.59361878
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.58420790
29AHR_22903824_ChIP-Seq_MCF-7_Human1.57837304
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.54489371
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54210164
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53155461
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.48244507
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48121345
35ER_23166858_ChIP-Seq_MCF-7_Human1.45514425
36TCF4_23295773_ChIP-Seq_U87_Human1.44999954
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.39444704
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38828937
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36893710
40CBP_20019798_ChIP-Seq_JUKART_Human1.36777885
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36777885
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36368879
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35557734
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35557734
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35030688
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.34590240
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34507584
48* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34020867
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33749233
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33074274
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32892379
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29780919
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29336642
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.27726636
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27209498
56P300_19829295_ChIP-Seq_ESCs_Human1.26915397
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.26229564
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25915516
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25031054
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.24887417
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24521077
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.23803052
63* GATA3_27048872_Chip-Seq_THYMUS_Human1.23313568
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.23125110
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23004724
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22830009
67GATA3_26560356_Chip-Seq_TH2_Human1.19036610
68MYB_26560356_Chip-Seq_TH2_Human1.18483965
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.17311881
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.16897972
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15300352
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14316974
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14219549
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12990605
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.12445375
76AR_25329375_ChIP-Seq_VCAP_Human1.07864078
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07225689
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05618378
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05450909
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04804004
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.04621136
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03912687
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02268579
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01813822
85CDX2_22108803_ChIP-Seq_LS180_Human1.00719048
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00281591
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99466209
88BCAT_22108803_ChIP-Seq_LS180_Human0.98865318
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98369061
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98358844
91SMRT_27268052_Chip-Seq_Bcells_Human0.97957687
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.97862971
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97636180
94MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97369897
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96360899
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95844474
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.95663585
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.95055150
99RUNX2_22187159_ChIP-Seq_PCA_Human0.94064022
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93554184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.14538435
2MP0000569_abnormal_digit_pigmentation4.80271330
3MP0002009_preneoplasia3.61619582
4MP0008057_abnormal_DNA_replication3.36518279
5MP0005167_abnormal_blood-brain_barrier3.19518971
6MP0004233_abnormal_muscle_weight3.16214307
7MP0004043_abnormal_pH_regulation3.03240644
8MP0003724_increased_susceptibility_to2.87112188
9MP0003045_fibrosis2.82400257
10MP0002396_abnormal_hematopoietic_system2.72315119
11MP0002234_abnormal_pharynx_morphology2.67931245
12MP0005645_abnormal_hypothalamus_physiol2.57362350
13MP0010307_abnormal_tumor_latency2.48976190
14MP0003763_abnormal_thymus_physiology2.42970176
15MP0010368_abnormal_lymphatic_system2.18248020
16MP0004084_abnormal_cardiac_muscle1.95441942
17MP0001835_abnormal_antigen_presentation1.80846775
18MP0003300_gastrointestinal_ulcer1.80066419
19MP0000015_abnormal_ear_pigmentation1.79908952
20MP0000383_abnormal_hair_follicle1.76629141
21MP0008877_abnormal_DNA_methylation1.76396693
22MP0005464_abnormal_platelet_physiology1.74131705
23MP0002166_altered_tumor_susceptibility1.72265654
24MP0005174_abnormal_tail_pigmentation1.70005168
25MP0003890_abnormal_embryonic-extraembry1.67915915
26MP0001919_abnormal_reproductive_system1.61129415
27MP0000566_synostosis1.52751511
28MP0001879_abnormal_lymphatic_vessel1.48630657
29MP0006082_CNS_inflammation1.44476964
30MP0004484_altered_response_of1.43069687
31MP0005409_darkened_coat_color1.34778787
32MP0002006_tumorigenesis1.32223291
33MP0010678_abnormal_skin_adnexa1.29486804
34MP0001661_extended_life_span1.29217332
35MP0003221_abnormal_cardiomyocyte_apopto1.28395100
36MP0003787_abnormal_imprinting1.26118381
37MP0003828_pulmonary_edema1.23954436
38MP0003866_abnormal_defecation1.23027648
39MP0004808_abnormal_hematopoietic_stem1.20638867
40MP0003656_abnormal_erythrocyte_physiolo1.16181507
41MP0004381_abnormal_hair_follicle1.15900945
42MP0001800_abnormal_humoral_immune1.15848286
43MP0009764_decreased_sensitivity_to1.14433779
44MP0009053_abnormal_anal_canal1.13327852
45MP0005076_abnormal_cell_differentiation1.12644117
46MP0000689_abnormal_spleen_morphology1.12577261
47MP0002398_abnormal_bone_marrow1.06899982
48MP0000733_abnormal_muscle_development1.03959500
49MP0000470_abnormal_stomach_morphology1.01625254
50MP0008775_abnormal_heart_ventricle1.00966667
51MP0000703_abnormal_thymus_morphology1.00358195
52MP0002452_abnormal_antigen_presenting0.99828915
53MP0004883_abnormal_blood_vessel0.99739583
54MP0001986_abnormal_taste_sensitivity0.99233927
55MP0003283_abnormal_digestive_organ0.98990732
56MP0004858_abnormal_nervous_system0.98006762
57MP0009697_abnormal_copulation0.97615196
58MP0002420_abnormal_adaptive_immunity0.97227935
59MP0002168_other_aberrant_phenotype0.95674720
60MP0002723_abnormal_immune_serum0.95585169
61MP0005671_abnormal_response_to0.95448843
62MP0005389_reproductive_system_phenotype0.95175534
63MP0001819_abnormal_immune_cell0.94820484
64MP0002722_abnormal_immune_system0.91854189
65MP0003121_genomic_imprinting0.91378343
66MP0000465_gastrointestinal_hemorrhage0.88491905
67MP0001664_abnormal_digestion0.87591996
68MP0006138_congestive_heart_failure0.86947962
69MP0004036_abnormal_muscle_relaxation0.86756087
70MP0008872_abnormal_physiological_respon0.86547650
71MP0005075_abnormal_melanosome_morpholog0.85151150
72MP0000467_abnormal_esophagus_morphology0.83831817
73MP0000716_abnormal_immune_system0.81458007
74MP0004134_abnormal_chest_morphology0.80357783
75MP0004130_abnormal_muscle_cell0.78293896
76MP0002109_abnormal_limb_morphology0.78169007
77MP0010352_gastrointestinal_tract_polyps0.77155387
78MP0005000_abnormal_immune_tolerance0.74434308
79MP0001784_abnormal_fluid_regulation0.74247724
80MP0002127_abnormal_cardiovascular_syste0.73298176
81MP0000631_abnormal_neuroendocrine_gland0.73205022
82MP0008058_abnormal_DNA_repair0.72239538
83MP0001119_abnormal_female_reproductive0.71216434
84MP0002084_abnormal_developmental_patter0.69440769
85MP0001501_abnormal_sleep_pattern0.69099154
86MP0002419_abnormal_innate_immunity0.68720724
87MP0005310_abnormal_salivary_gland0.67373789
88MP0002928_abnormal_bile_duct0.66564122
89MP0001790_abnormal_immune_system0.66264151
90MP0005387_immune_system_phenotype0.66264151
91MP0002405_respiratory_system_inflammati0.66065376
92MP0002429_abnormal_blood_cell0.65953345
93MP0001756_abnormal_urination0.65728548
94MP0002086_abnormal_extraembryonic_tissu0.63235134
95MP0008004_abnormal_stomach_pH0.63143113
96MP0009703_decreased_birth_body0.62923518
97MP0002088_abnormal_embryonic_growth/wei0.62472098
98MP0001915_intracranial_hemorrhage0.62058492
99MP0002233_abnormal_nose_morphology0.60910944
100MP0000428_abnormal_craniofacial_morphol0.60781595

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)5.76009161
2Abnormality of the fingertips (HP:0001211)5.40936383
3Sparse lateral eyebrow (HP:0005338)5.02121224
4Lip pit (HP:0100267)4.85794277
5Anal stenosis (HP:0002025)4.77461755
6Depressed nasal tip (HP:0000437)3.77994889
7Ectopic kidney (HP:0000086)3.34121854
8Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.17265538
9Ureteral obstruction (HP:0006000)3.14678965
10Short 5th finger (HP:0009237)3.13999496
11Abnormality of the renal cortex (HP:0011035)3.10417533
12Intestinal fistula (HP:0100819)3.07662733
13Ureteral stenosis (HP:0000071)3.05119298
14Narrow palate (HP:0000189)2.84577019
15Volvulus (HP:0002580)2.76988502
16Pancreatic cysts (HP:0001737)2.74423205
17Ectropion (HP:0000656)2.69485968
18Lower limb hyperreflexia (HP:0002395)2.60650516
19IgM deficiency (HP:0002850)2.58827159
20Blue irides (HP:0000635)2.56749387
21Abnormality of chromosome stability (HP:0003220)2.56513968
22Wide intermamillary distance (HP:0006610)2.49409891
23Fibular aplasia (HP:0002990)2.36988407
24T lymphocytopenia (HP:0005403)2.33653010
25Transitional cell carcinoma of the bladder (HP:0006740)2.29394121
26Panhypogammaglobulinemia (HP:0003139)2.25958850
27Curly hair (HP:0002212)2.25053556
28Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.24900402
29Pheochromocytoma (HP:0002666)2.24292003
30Bladder neoplasm (HP:0009725)2.22037237
31Bladder carcinoma (HP:0002862)2.22037237
32Abnormality of T cell number (HP:0011839)2.20444565
33Fair hair (HP:0002286)2.17665272
34Renal cortical cysts (HP:0000803)2.13189025
35Gaze-evoked nystagmus (HP:0000640)2.06772993
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.04013534
37Prolonged bleeding time (HP:0003010)2.00368827
38Partial agenesis of the corpus callosum (HP:0001338)1.99481102
39Absent eyebrow (HP:0002223)1.98795743
40Stomatitis (HP:0010280)1.98396023
41Coarse hair (HP:0002208)1.97728021
42Chronic hepatic failure (HP:0100626)1.97633813
43Viral hepatitis (HP:0006562)1.96195791
44Thyroiditis (HP:0100646)1.95748080
45Hyperventilation (HP:0002883)1.94412199
46Papillary thyroid carcinoma (HP:0002895)1.93866322
47Abnormality of B cell number (HP:0010975)1.93783371
48Chromsome breakage (HP:0040012)1.93336141
49Subacute progressive viral hepatitis (HP:0006572)1.91531330
50Neuroendocrine neoplasm (HP:0100634)1.90395854
51Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.89563377
52Central scotoma (HP:0000603)1.87947579
53Uterine leiomyosarcoma (HP:0002891)1.87593795
54Leiomyosarcoma (HP:0100243)1.87593795
55Posterior subcapsular cataract (HP:0007787)1.87586317
56Clubbing of toes (HP:0100760)1.87458916
57Acute hepatic failure (HP:0006554)1.87409954
58Thyroid carcinoma (HP:0002890)1.85687751
59Truncal obesity (HP:0001956)1.84125225
60Increased CSF protein (HP:0002922)1.83042906
61Tubular atrophy (HP:0000092)1.82763918
62IgA deficiency (HP:0002720)1.82358639
63Preauricular pit (HP:0004467)1.82180303
64Periauricular skin pits (HP:0100277)1.82180303
65Autoimmune hemolytic anemia (HP:0001890)1.79722970
66Chronic diarrhea (HP:0002028)1.79291811
67Spontaneous hematomas (HP:0007420)1.79181096
68Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78936986
69Hypoplastic labia majora (HP:0000059)1.78680212
70Abnormality of the renal medulla (HP:0100957)1.76074941
71Severe visual impairment (HP:0001141)1.75703587
72Sandal gap (HP:0001852)1.75666681
73Abnormality of the periventricular white matter (HP:0002518)1.75048092
74Polydipsia (HP:0001959)1.73586552
75Abnormal drinking behavior (HP:0030082)1.73586552
76Tinnitus (HP:0000360)1.73316135
77Astrocytoma (HP:0009592)1.72618104
78Abnormality of the astrocytes (HP:0100707)1.72618104
79Glioma (HP:0009733)1.71840771
80Deep philtrum (HP:0002002)1.71603986
81Recurrent fungal infections (HP:0002841)1.71107476
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.70794095
83Mask-like facies (HP:0000298)1.69738234
84Widely spaced teeth (HP:0000687)1.69119781
85Cafe-au-lait spot (HP:0000957)1.69065986
86Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68720585
87Asymmetry of the thorax (HP:0001555)1.67464636
88Abnormality of the labia majora (HP:0012881)1.67424140
89Cupped ear (HP:0000378)1.66819581
90Thick eyebrow (HP:0000574)1.66706014
91Hypoplastic iliac wings (HP:0002866)1.66372910
92Recurrent bacterial skin infections (HP:0005406)1.65297978
93Abnormality of T cells (HP:0002843)1.65175750
94Atonic seizures (HP:0010819)1.65152541
95Self-mutilation (HP:0000742)1.65013283
96Hypothermia (HP:0002045)1.64727354
97Recurrent cutaneous fungal infections (HP:0011370)1.63666890
98Chronic mucocutaneous candidiasis (HP:0002728)1.63666890
99Acute myeloid leukemia (HP:0004808)1.63534993
100Neoplasm of the tracheobronchial system (HP:0100552)1.63388261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK245.14184075
2FRK3.24114610
3STK393.19865334
4MAP3K22.91812467
5WNK42.78100494
6JAK32.29287387
7TAOK32.22303881
8AKT32.16134476
9CCNB12.16063840
10WNK12.12927658
11EEF2K1.87540558
12PINK11.83107164
13NUAK11.70453223
14IRAK11.70289716
15ZAK1.66677672
16BMPR1B1.65981278
17LATS11.63885660
18TEC1.60852712
19TXK1.59629600
20CAMK1G1.48953158
21BLK1.41898940
22SGK21.36987034
23CAMK41.36939937
24NEK91.33251447
25MAP3K31.33055067
26IRAK21.32465116
27CAMKK21.30856654
28BRD41.29049875
29PRKCQ1.25883898
30CAMK1D1.24983065
31FES1.20887066
32CSNK1A1L1.20720768
33BTK1.19966368
34ILK1.17176533
35CDK121.08372624
36TRPM71.07720652
37MAP4K21.06203178
38SGK31.05318636
39HCK1.00708590
40JAK11.00325259
41PIK3CG0.96195042
42CDC70.94349692
43RPS6KA60.94346564
44TNIK0.93408400
45TNK20.93132441
46MAP3K100.92183531
47ACVR1B0.91756596
48RPS6KC10.91172201
49RPS6KL10.91172201
50CAMK10.89836328
51SYK0.86804447
52RPS6KB20.84689690
53CSNK1G20.84356286
54FER0.84333451
55MAP3K40.84328190
56CSNK1G30.79727186
57EPHA30.78609311
58CHEK20.76643512
59CSNK1G10.73558222
60ADRBK20.70783596
61CDK90.70608894
62PIK3CA0.69591861
63SGK2230.67206825
64SGK4940.67206825
65ERBB30.63328223
66RAF10.62406126
67NLK0.60458400
68STK40.59410847
69ITK0.58955649
70IKBKE0.58697391
71YES10.57913902
72CSK0.57230049
73LYN0.56263569
74MAPKAPK30.56213260
75IRAK40.55560933
76PNCK0.53969184
77KIT0.53681367
78EGFR0.51436429
79RIPK40.49658958
80JAK20.47621619
81PTK2B0.46269155
82MAPKAPK50.45525128
83PDGFRB0.45480536
84PIM10.45092706
85MAPK130.44806472
86DYRK30.43668725
87MAP3K140.43595513
88NTRK20.41729305
89PAK30.40468849
90FGFR30.39216708
91GRK60.39210078
92SRPK10.38869588
93DAPK20.38739114
94GRK10.37974530
95PRKAA20.37281836
96LCK0.37229064
97ERBB20.35936119
98MAP3K70.35879002
99ATM0.35789716
100OXSR10.35182477

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.22308663
2Jak-STAT signaling pathway_Homo sapiens_hsa046301.82298597
3Lysine degradation_Homo sapiens_hsa003101.79743492
4Dorso-ventral axis formation_Homo sapiens_hsa043201.78825457
5Platelet activation_Homo sapiens_hsa046111.68732965
6Non-small cell lung cancer_Homo sapiens_hsa052231.64621784
7B cell receptor signaling pathway_Homo sapiens_hsa046621.59224303
8Systemic lupus erythematosus_Homo sapiens_hsa053221.53501719
9T cell receptor signaling pathway_Homo sapiens_hsa046601.47958765
10Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43725724
11Endometrial cancer_Homo sapiens_hsa052131.42767891
12Long-term depression_Homo sapiens_hsa047301.41655753
13Measles_Homo sapiens_hsa051621.40698121
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38583110
15Primary immunodeficiency_Homo sapiens_hsa053401.35384485
16Prolactin signaling pathway_Homo sapiens_hsa049171.28455743
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26005333
18Glioma_Homo sapiens_hsa052141.25641628
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25412797
20Alcoholism_Homo sapiens_hsa050341.25248796
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22559299
22Choline metabolism in cancer_Homo sapiens_hsa052311.20689479
23FoxO signaling pathway_Homo sapiens_hsa040681.16745332
24Pancreatic cancer_Homo sapiens_hsa052121.14636954
25Fanconi anemia pathway_Homo sapiens_hsa034601.14075476
26mTOR signaling pathway_Homo sapiens_hsa041501.11838845
27Hepatitis B_Homo sapiens_hsa051611.11515615
28Osteoclast differentiation_Homo sapiens_hsa043801.10764884
29Inositol phosphate metabolism_Homo sapiens_hsa005621.10314164
30Prostate cancer_Homo sapiens_hsa052151.09111205
31Chemokine signaling pathway_Homo sapiens_hsa040621.06890282
32Renal cell carcinoma_Homo sapiens_hsa052111.05645037
33Leishmaniasis_Homo sapiens_hsa051401.05288555
34Tuberculosis_Homo sapiens_hsa051521.05148770
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.05050148
36AMPK signaling pathway_Homo sapiens_hsa041521.04997018
37Chronic myeloid leukemia_Homo sapiens_hsa052201.03782730
38Hematopoietic cell lineage_Homo sapiens_hsa046400.99957466
39Sphingolipid signaling pathway_Homo sapiens_hsa040710.98155637
40Acute myeloid leukemia_Homo sapiens_hsa052210.97529196
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96950499
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95718753
43Colorectal cancer_Homo sapiens_hsa052100.94662915
44TGF-beta signaling pathway_Homo sapiens_hsa043500.94342465
45Hepatitis C_Homo sapiens_hsa051600.93224690
46Type II diabetes mellitus_Homo sapiens_hsa049300.93097104
47Selenocompound metabolism_Homo sapiens_hsa004500.92938070
48Toxoplasmosis_Homo sapiens_hsa051450.89761190
49Graft-versus-host disease_Homo sapiens_hsa053320.86561573
50Influenza A_Homo sapiens_hsa051640.86419639
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84740596
52Small cell lung cancer_Homo sapiens_hsa052220.84434751
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.84168246
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84159006
55Viral carcinogenesis_Homo sapiens_hsa052030.83808334
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83351239
57Oxytocin signaling pathway_Homo sapiens_hsa049210.82760106
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.81549694
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79892504
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78904988
61Melanoma_Homo sapiens_hsa052180.78428010
62Phototransduction_Homo sapiens_hsa047440.78377909
63ABC transporters_Homo sapiens_hsa020100.77170828
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.75238283
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74960457
66mRNA surveillance pathway_Homo sapiens_hsa030150.74922657
67Olfactory transduction_Homo sapiens_hsa047400.74554032
68Taste transduction_Homo sapiens_hsa047420.74184543
69Herpes simplex infection_Homo sapiens_hsa051680.71762269
70p53 signaling pathway_Homo sapiens_hsa041150.71313850
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70874191
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70855009
73Renin secretion_Homo sapiens_hsa049240.70532184
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68899555
75Circadian entrainment_Homo sapiens_hsa047130.68749477
76ErbB signaling pathway_Homo sapiens_hsa040120.68643656
77Staphylococcus aureus infection_Homo sapiens_hsa051500.68394442
78Salivary secretion_Homo sapiens_hsa049700.67772097
79MicroRNAs in cancer_Homo sapiens_hsa052060.64164814
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63847233
81Insulin signaling pathway_Homo sapiens_hsa049100.63014719
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62389863
83Regulation of autophagy_Homo sapiens_hsa041400.60374058
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59168472
85Basal transcription factors_Homo sapiens_hsa030220.59092057
86TNF signaling pathway_Homo sapiens_hsa046680.58849321
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58305859
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58144107
89Cholinergic synapse_Homo sapiens_hsa047250.57421572
90Legionellosis_Homo sapiens_hsa051340.56316453
91Allograft rejection_Homo sapiens_hsa053300.56080534
92Estrogen signaling pathway_Homo sapiens_hsa049150.54276941
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54244316
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.54103503
95cAMP signaling pathway_Homo sapiens_hsa040240.53752781
96Homologous recombination_Homo sapiens_hsa034400.51839857
97Autoimmune thyroid disease_Homo sapiens_hsa053200.51551382
98Endocytosis_Homo sapiens_hsa041440.50274555
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49945167
100Dopaminergic synapse_Homo sapiens_hsa047280.49401590

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