ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	4.84433761
2	ectoderm development (GO:0007398)	4.73164044
3	piRNA metabolic process (GO:0034587)	4.69156799
4	keratinocyte development (GO:0003334)	4.65469520
5	phasic smooth muscle contraction (GO:0014821)	4.58833993
6	regulation of acrosome reaction (GO:0060046)	4.56748359
7	peristalsis (GO:0030432)	4.56245732
8	keratinization (GO:0031424)	4.43623480
9	DNA double-strand break processing (GO:0000729)	4.18595758
10	DNA methylation involved in gamete generation (GO:0043046)	4.02882662
11	regulation of hippo signaling (GO:0035330)	4.00820928
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.96879586
13	detection of light stimulus involved in visual perception (GO:0050908)	3.96879586
14	regulation of action potential (GO:0098900)	3.91773590
15	ribosome assembly (GO:0042255)	3.86080074
16	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.73438440
17	protein K11-linked deubiquitination (GO:0035871)	3.62843775
18	establishment of protein localization to Golgi (GO:0072600)	3.59826474
19	tachykinin receptor signaling pathway (GO:0007217)	3.54403386
20	neuronal action potential (GO:0019228)	3.50850170
21	primary alcohol catabolic process (GO:0034310)	3.49062008
22	protein targeting to Golgi (GO:0000042)	3.47767942
23	response to pheromone (GO:0019236)	3.45177833
24	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.38894638
25	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.34991288
26	urinary tract smooth muscle contraction (GO:0014848)	3.34487838
27	keratinocyte differentiation (GO:0030216)	3.33777754
28	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.31878180
29	cellular ketone body metabolic process (GO:0046950)	3.24274042
30	regulation of meiosis I (GO:0060631)	3.17561575
31	fusion of sperm to egg plasma membrane (GO:0007342)	3.15287939
32	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.13717413
33	histone H2A acetylation (GO:0043968)	3.12149807
34	ketone body metabolic process (GO:1902224)	3.09484417
35	protein-cofactor linkage (GO:0018065)	3.09337161
36	desmosome organization (GO:0002934)	3.08284989
37	intestinal epithelial cell development (GO:0060576)	3.08014099
38	fatty acid elongation (GO:0030497)	3.07135540
39	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.06096854
40	sphingoid metabolic process (GO:0046519)	3.00741040
41	regulation of glucokinase activity (GO:0033131)	3.00717955
42	regulation of hexokinase activity (GO:1903299)	3.00717955
43	transepithelial transport (GO:0070633)	2.90886468
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.90414617
45	intra-Golgi vesicle-mediated transport (GO:0006891)	2.89983379
46	glutathione biosynthetic process (GO:0006750)	2.86366461
47	cornea development in camera-type eye (GO:0061303)	2.84937986
48	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.84782307
49	centriole replication (GO:0007099)	2.83093315
50	nonribosomal peptide biosynthetic process (GO:0019184)	2.77396743
51	peptide cross-linking (GO:0018149)	2.76930875
52	DNA integration (GO:0015074)	2.75781905
53	positive regulation of protein autophosphorylation (GO:0031954)	2.75733487
54	retinal cone cell development (GO:0046549)	2.73716270
55	regulation of protein glycosylation (GO:0060049)	2.73138211
56	sympathetic nervous system development (GO:0048485)	2.72212758
57	intraciliary transport (GO:0042073)	2.71781351
58	negative regulation of T cell apoptotic process (GO:0070233)	2.69388469
59	axoneme assembly (GO:0035082)	2.66219461
60	branched-chain amino acid catabolic process (GO:0009083)	2.64482334
61	photoreceptor cell maintenance (GO:0045494)	2.64406465
62	protein localization to Golgi apparatus (GO:0034067)	2.64235726
63	gonadal mesoderm development (GO:0007506)	2.63929293
64	negative regulation of dendrite development (GO:2000171)	2.60242557
65	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.59731269
66	DNA catabolic process, exonucleolytic (GO:0000738)	2.59199211
67	photoreceptor cell development (GO:0042461)	2.59056717
68	establishment of skin barrier (GO:0061436)	2.58158102
69	glutathione derivative biosynthetic process (GO:1901687)	2.56783736
70	glutathione derivative metabolic process (GO:1901685)	2.56783736
71	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.56236154
72	regulation of DNA endoreduplication (GO:0032875)	2.55038929
73	behavioral response to ethanol (GO:0048149)	2.54235596
74	carnitine metabolic process (GO:0009437)	2.53686638
75	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.51772601
76	epidermal cell differentiation (GO:0009913)	2.51696315
77	cilium or flagellum-dependent cell motility (GO:0001539)	2.51378583
78	inositol phosphate catabolic process (GO:0071545)	2.51196504
79	lipopolysaccharide biosynthetic process (GO:0009103)	2.50727968
80	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.50528360
81	epithelial cilium movement (GO:0003351)	2.49411701
82	eye photoreceptor cell development (GO:0042462)	2.49354608
83	multicellular organism reproduction (GO:0032504)	2.48944118
84	C4-dicarboxylate transport (GO:0015740)	2.48343841
85	gene silencing by RNA (GO:0031047)	2.48085378
86	polyol catabolic process (GO:0046174)	2.45717642
87	cilium morphogenesis (GO:0060271)	2.44048076
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.43326980
89	protein K6-linked ubiquitination (GO:0085020)	2.43126921
90	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.42712162
91	short-chain fatty acid metabolic process (GO:0046459)	2.42233499
92	C-terminal protein lipidation (GO:0006501)	2.41488290
93	recombinational repair (GO:0000725)	2.40379408
94	double-strand break repair via homologous recombination (GO:0000724)	2.40240068
95	sphingosine metabolic process (GO:0006670)	2.39434209
96	adenosine metabolic process (GO:0046085)	2.38117534
97	indolalkylamine metabolic process (GO:0006586)	2.37134601
98	mammary gland epithelial cell differentiation (GO:0060644)	2.37097608
99	respiratory chain complex IV assembly (GO:0008535)	2.36015266
100	reflex (GO:0060004)	2.35178887

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.50427116
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.36811745
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.20568716
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.03912359
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.92534103
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.88362412
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.74969283
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.68981628
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.45071725
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.44898305
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.40125349
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35473938
13	FUS_26573619_Chip-Seq_HEK293_Human	2.34591011
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.24395744
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.21037307
16	P300_19829295_ChIP-Seq_ESCs_Human	2.13778780
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.13513813
18	EWS_26573619_Chip-Seq_HEK293_Human	1.97668776
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.87924061
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.79002398
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.74492405
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70623570
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.69271822
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.68612153
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.66485376
26	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.64187297
27	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.63366952
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62891317
29	AR_25329375_ChIP-Seq_VCAP_Human	1.60412054
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60175455
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59959689
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59211957
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57699591
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57483932
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.57014412
36	STAT3_23295773_ChIP-Seq_U87_Human	1.55544165
37	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.52462169
38	ELF5_23300383_ChIP-Seq_T47D_Human	1.52123815
39	TCF4_23295773_ChIP-Seq_U87_Human	1.51994260
40	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.51323303
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50564155
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49032484
43	TCF4_22108803_ChIP-Seq_LS180_Human	1.48449508
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.44161902
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44161902
46	HOXB7_26014856_ChIP-Seq_BT474_Human	1.43664678
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42558372
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38208523
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.35558763
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34848132
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34841037
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34682429
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34533716
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34065544
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33321522
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33321522
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.31327736
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30481802
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29192390
60	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28277629
61	RXR_22108803_ChIP-Seq_LS180_Human	1.28277586
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.27975689
63	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.27647275
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27620900
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26751837
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26474970
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26474970
68	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.25716655
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.25535654
70	AHR_22903824_ChIP-Seq_MCF-7_Human	1.23802483
71	AR_20517297_ChIP-Seq_VCAP_Human	1.23447415
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22554905
73	NCOR_22424771_ChIP-Seq_293T_Human	1.21488022
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20674835
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18577450
76	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.18365941
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16184181
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16107755
79	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15404243
80	CJUN_26792858_Chip-Seq_BT549_Human	1.14611112
81	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12341138
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12341138
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11352399
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10479164
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10350417
86	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.09991012
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09003708
88	TP53_22573176_ChIP-Seq_HFKS_Human	1.07943164
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07912125
90	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.07522458
91	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07242936
92	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.06385717
93	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05603061
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04996490
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04305399
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03965449
97	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03372699
98	P300_18555785_Chip-Seq_ESCs_Mouse	1.03336428
99	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.02329167
100	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.02257070

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	6.91405950
2	MP0003195_calcinosis	3.86463560
3	MP0008877_abnormal_DNA_methylation	3.14823254
4	MP0004043_abnormal_pH_regulation	2.93936841
5	MP0000372_irregular_coat_pigmentation	2.78069555
6	MP0010678_abnormal_skin_adnexa	2.68194453
7	MP0008057_abnormal_DNA_replication	2.67084028
8	MP0000427_abnormal_hair_cycle	2.54863624
9	MP0002796_impaired_skin_barrier	2.41103394
10	MP0003950_abnormal_plasma_membrane	2.18330818
11	MP0005075_abnormal_melanosome_morpholog	2.07059859
12	MP0002098_abnormal_vibrissa_morphology	2.04699904
13	MP0005551_abnormal_eye_electrophysiolog	2.02608833
14	MP0003045_fibrosis	1.94542059
15	MP0005171_absent_coat_pigmentation	1.84728872
16	MP0002837_dystrophic_cardiac_calcinosis	1.81717661
17	MP0002822_catalepsy	1.78968094
18	MP0003787_abnormal_imprinting	1.75956518
19	MP0004264_abnormal_extraembryonic_tissu	1.74788823
20	MP0005670_abnormal_white_adipose	1.65980646
21	MP0002168_other_aberrant_phenotype	1.63946903
22	MP0000647_abnormal_sebaceous_gland	1.62757087
23	MP0005083_abnormal_biliary_tract	1.60585702
24	MP0006276_abnormal_autonomic_nervous	1.53706024
25	MP0005646_abnormal_pituitary_gland	1.52072667
26	MP0000383_abnormal_hair_follicle	1.51800787
27	MP0002102_abnormal_ear_morphology	1.51525981
28	MP0005645_abnormal_hypothalamus_physiol	1.48796357
29	MP0005501_abnormal_skin_physiology	1.48399843
30	MP0005395_other_phenotype	1.46687266
31	MP0003718_maternal_effect	1.43756793
32	MP0009780_abnormal_chondrocyte_physiolo	1.43431524
33	MP0003136_yellow_coat_color	1.39128687
34	MP0002653_abnormal_ependyma_morphology	1.36221054
35	MP0008058_abnormal_DNA_repair	1.35430851
36	MP0005408_hypopigmentation	1.34933933
37	MP0004215_abnormal_myocardial_fiber	1.31094652
38	MP0008789_abnormal_olfactory_epithelium	1.30072141
39	MP0003878_abnormal_ear_physiology	1.27265977
40	MP0005377_hearing/vestibular/ear_phenot	1.27265977
41	MP0002234_abnormal_pharynx_morphology	1.21768786
42	MP0005187_abnormal_penis_morphology	1.20189979
43	MP0001529_abnormal_vocalization	1.19696396
44	MP0002095_abnormal_skin_pigmentation	1.19050250
45	MP0001486_abnormal_startle_reflex	1.17408773
46	MP0005253_abnormal_eye_physiology	1.14600636
47	MP0009046_muscle_twitch	1.11774316
48	MP0003011_delayed_dark_adaptation	1.10402827
49	MP0001346_abnormal_lacrimal_gland	1.08724835
50	MP0005379_endocrine/exocrine_gland_phen	1.07442574
51	MP0000613_abnormal_salivary_gland	1.07360481
52	MP0001881_abnormal_mammary_gland	1.06970720
53	MP0002638_abnormal_pupillary_reflex	1.06604836
54	MP0004381_abnormal_hair_follicle	1.00578476
55	MP0008995_early_reproductive_senescence	0.99676112
56	MP0000569_abnormal_digit_pigmentation	0.96632743
57	MP0004147_increased_porphyrin_level	0.94518879
58	MP0005310_abnormal_salivary_gland	0.93048123
59	MP0009697_abnormal_copulation	0.90659638
60	MP0001765_abnormal_ion_homeostasis	0.90197590
61	MP0001929_abnormal_gametogenesis	0.89401101
62	MP0000631_abnormal_neuroendocrine_gland	0.88895203
63	MP0005636_abnormal_mineral_homeostasis	0.88892341
64	MP0003943_abnormal_hepatobiliary_system	0.88789246
65	MP0002736_abnormal_nociception_after	0.88732256
66	MP0004484_altered_response_of	0.87676386
67	MP0003698_abnormal_male_reproductive	0.87042219
68	MP0000579_abnormal_nail_morphology	0.86326391
69	MP0001968_abnormal_touch/_nociception	0.86238851
70	MP0005174_abnormal_tail_pigmentation	0.86089123
71	MP0000371_diluted_coat_color	0.84262178
72	MP0001919_abnormal_reproductive_system	0.83916763
73	MP0010094_abnormal_chromosome_stability	0.82982903
74	MP0002751_abnormal_autonomic_nervous	0.82623363
75	MP0002163_abnormal_gland_morphology	0.82417221
76	MP0000377_abnormal_hair_follicle	0.81659168
77	MP0002938_white_spotting	0.81399840
78	MP0008872_abnormal_physiological_respon	0.80386375
79	MP0010771_integument_phenotype	0.79077171
80	MP0005410_abnormal_fertilization	0.78857733
81	MP0002160_abnormal_reproductive_system	0.78441920
82	MP0005389_reproductive_system_phenotype	0.78434874
83	MP0003755_abnormal_palate_morphology	0.77594540
84	MP0000653_abnormal_sex_gland	0.76439246
85	MP0000015_abnormal_ear_pigmentation	0.76410395
86	MP0005085_abnormal_gallbladder_physiolo	0.74779625
87	MP0001216_abnormal_epidermal_layer	0.74513140
88	MP0008875_abnormal_xenobiotic_pharmacok	0.74157971
89	MP0002210_abnormal_sex_determination	0.73423704
90	MP0004019_abnormal_vitamin_homeostasis	0.72926119
91	MP0003137_abnormal_impulse_conducting	0.72433935
92	MP0001145_abnormal_male_reproductive	0.71186765
93	MP0001984_abnormal_olfaction	0.70678757
94	MP0002229_neurodegeneration	0.70448905
95	MP0003936_abnormal_reproductive_system	0.70227672
96	MP0009745_abnormal_behavioral_response	0.69399885
97	MP0003121_genomic_imprinting	0.68129464
98	MP0000467_abnormal_esophagus_morphology	0.67551387
99	MP0000762_abnormal_tongue_morphology	0.66040529
100	MP0001501_abnormal_sleep_pattern	0.65890957

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.24541007
2	Pancreatic fibrosis (HP:0100732)	3.81693529
3	True hermaphroditism (HP:0010459)	3.69148744
4	Congenital stationary night blindness (HP:0007642)	3.51800222
5	Abnormality of the renal cortex (HP:0011035)	3.48809867
6	Molar tooth sign on MRI (HP:0002419)	3.24108042
7	Abnormality of midbrain morphology (HP:0002418)	3.24108042
8	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.20917814
9	Furrowed tongue (HP:0000221)	3.13940900
10	Abnormality of the renal medulla (HP:0100957)	3.12222657
11	Curly hair (HP:0002212)	2.90612034
12	Nephronophthisis (HP:0000090)	2.84937172
13	Decreased central vision (HP:0007663)	2.82907131
14	Abnormality of macular pigmentation (HP:0008002)	2.74272163
15	Lip pit (HP:0100267)	2.73927980
16	Cystic liver disease (HP:0006706)	2.72924770
17	Tubulointerstitial nephritis (HP:0001970)	2.70715671
18	Amelogenesis imperfecta (HP:0000705)	2.68866471
19	Pili torti (HP:0003777)	2.67618518
20	Congenital ichthyosiform erythroderma (HP:0007431)	2.58936766
21	Alopecia of scalp (HP:0002293)	2.55724405
22	Volvulus (HP:0002580)	2.54279488
23	Hypoplastic labia majora (HP:0000059)	2.49467032
24	Renal cortical cysts (HP:0000803)	2.47450212
25	Hypothermia (HP:0002045)	2.47151110
26	Gaze-evoked nystagmus (HP:0000640)	2.45128288
27	Erythroderma (HP:0001019)	2.35397698
28	Large for gestational age (HP:0001520)	2.35364727
29	Decreased circulating renin level (HP:0003351)	2.33305277
30	Abnormality of the labia majora (HP:0012881)	2.32248070
31	Tubular atrophy (HP:0000092)	2.31051677
32	Parakeratosis (HP:0001036)	2.27104262
33	Hyperactive renin-angiotensin system (HP:0000841)	2.20943818
34	Abolished electroretinogram (ERG) (HP:0000550)	2.18989505
35	Intestinal atresia (HP:0011100)	2.18209802
36	Abnormal hair laboratory examination (HP:0003328)	2.14061989
37	Pendular nystagmus (HP:0012043)	2.11448752
38	Hyperventilation (HP:0002883)	2.08275133
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.07848240
40	Septate vagina (HP:0001153)	2.06143984
41	Fair hair (HP:0002286)	2.04263554
42	Horizontal nystagmus (HP:0000666)	2.03186179
43	Renal salt wasting (HP:0000127)	2.01254958
44	Chronic hepatic failure (HP:0100626)	2.00786323
45	Hypokalemic alkalosis (HP:0001949)	2.00236217
46	Blepharitis (HP:0000498)	1.99215500
47	Abnormal biliary tract physiology (HP:0012439)	1.97427369
48	Bile duct proliferation (HP:0001408)	1.97427369
49	Attenuation of retinal blood vessels (HP:0007843)	1.97173999
50	Stomach cancer (HP:0012126)	1.95202635
51	Medial flaring of the eyebrow (HP:0010747)	1.93414578
52	Absent speech (HP:0001344)	1.92649941
53	Glioma (HP:0009733)	1.92390278
54	Posterior subcapsular cataract (HP:0007787)	1.92130507
55	Generalized hypopigmentation of hair (HP:0011358)	1.92091439
56	Genetic anticipation (HP:0003743)	1.91450319
57	Disproportionate short-trunk short stature (HP:0003521)	1.91289491
58	Progressive cerebellar ataxia (HP:0002073)	1.90798703
59	Astrocytoma (HP:0009592)	1.89117880
60	Abnormality of the astrocytes (HP:0100707)	1.89117880
61	Sclerocornea (HP:0000647)	1.87380395
62	Type II lissencephaly (HP:0007260)	1.87351825
63	Anencephaly (HP:0002323)	1.86234899
64	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.84553403
65	Abnormality of nail color (HP:0100643)	1.84510783
66	Hyperglycinuria (HP:0003108)	1.83286564
67	Congenital hepatic fibrosis (HP:0002612)	1.82550533
68	Progressive macrocephaly (HP:0004481)	1.82328318
69	Acute encephalopathy (HP:0006846)	1.82284169
70	Postaxial foot polydactyly (HP:0001830)	1.82166547
71	Abnormality of the axillary hair (HP:0100134)	1.81822879
72	Abnormality of secondary sexual hair (HP:0009888)	1.81822879
73	Right ventricular cardiomyopathy (HP:0011663)	1.79702242
74	Keratoconus (HP:0000563)	1.79394180
75	Increased corneal curvature (HP:0100692)	1.79394180
76	Dyskinesia (HP:0100660)	1.79355145
77	Tongue fasciculations (HP:0001308)	1.79235093
78	Ulnar claw (HP:0001178)	1.79011923
79	Male pseudohermaphroditism (HP:0000037)	1.77523476
80	Abnormality of dental color (HP:0011073)	1.77433032
81	Widely spaced teeth (HP:0000687)	1.76992847
82	Abnormal rod and cone electroretinograms (HP:0008323)	1.76955484
83	Hyperkalemia (HP:0002153)	1.74766626
84	Ectropion (HP:0000656)	1.74630109
85	Facial diplegia (HP:0001349)	1.74070004
86	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72731880
87	Popliteal pterygium (HP:0009756)	1.72453310
88	Hamartoma of the eye (HP:0010568)	1.71992150
89	Ketoacidosis (HP:0001993)	1.68451083
90	Acute necrotizing encephalopathy (HP:0006965)	1.67330922
91	Gonadotropin excess (HP:0000837)	1.67170511
92	Abnormality of renin-angiotensin system (HP:0000847)	1.66867234
93	Neoplasm of the adrenal cortex (HP:0100641)	1.66782350
94	Labial hypoplasia (HP:0000066)	1.66180734
95	Tented upper lip vermilion (HP:0010804)	1.66041898
96	Palmar hyperkeratosis (HP:0010765)	1.65690346
97	Small hand (HP:0200055)	1.64938936
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.64434232
99	Stenosis of the external auditory canal (HP:0000402)	1.64182652
100	Chronic bronchitis (HP:0004469)	1.64030807

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.61900508
2	MST4	4.12741057
3	TRIM28	3.16425584
4	EIF2AK3	2.84562344
5	WNK3	2.65744309
6	NUAK1	2.64092969
7	MAPKAPK3	2.34944301
8	CASK	2.31323645
9	ERBB3	2.00739638
10	EPHA2	1.96317335
11	BMPR1B	1.90836175
12	STK38L	1.88470706
13	MAP4K2	1.83274871
14	GRK1	1.81563093
15	FER	1.76785052
16	ZAK	1.75459788
17	NTRK3	1.58591919
18	EIF2AK1	1.56931174
19	STK39	1.55148052
20	ACVR1B	1.51252532
21	TAOK3	1.49973553
22	VRK2	1.47107055
23	TNIK	1.42103884
24	BCR	1.41592784
25	GRK5	1.39371703
26	MAP3K12	1.37053757
27	ADRBK2	1.36317733
28	MAPK13	1.36256068
29	RPS6KB2	1.33017413
30	BRSK2	1.32739704
31	MAP3K2	1.32691421
32	PINK1	1.26645065
33	PDK2	1.26225241
34	OXSR1	1.23034243
35	BCKDK	1.22101781
36	WEE1	1.20663100
37	PRKCI	1.15614282
38	LATS1	1.15292027
39	CDK3	1.10864355
40	STK3	1.10546944
41	NEK6	1.03530084
42	BMPR2	1.00468967
43	PLK2	0.94529914
44	PAK3	0.91889532
45	CCNB1	0.83396933
46	CDK8	0.81453004
47	TNK2	0.77528424
48	WNK4	0.76441562
49	PRKCE	0.75255644
50	MAP3K4	0.72712846
51	MKNK2	0.71859659
52	TGFBR1	0.68356429
53	PKN2	0.67406472
54	MUSK	0.66210155
55	DMPK	0.65034397
56	INSRR	0.62891114
57	PLK3	0.62551168
58	MAP2K6	0.62063788
59	PIK3CG	0.61680714
60	ADRBK1	0.60799421
61	NEK1	0.59884109
62	TEC	0.56893326
63	EPHA4	0.56074754
64	CSNK1A1	0.54926316
65	SIK2	0.53802956
66	MAP2K1	0.53545736
67	ATR	0.52789512
68	PTK2B	0.51391272
69	CHEK2	0.50926465
70	CAMK2D	0.49715890
71	DDR2	0.48998129
72	MINK1	0.48587372
73	ATM	0.48525230
74	CSNK1G3	0.48351889
75	TSSK6	0.47390415
76	CSNK1G1	0.46027265
77	CSNK1A1L	0.45385353
78	PRKAA2	0.44983606
79	AKT3	0.43455518
80	ILK	0.43230206
81	STK24	0.41214158
82	SIK3	0.36516152
83	DYRK1A	0.35348593
84	VRK1	0.35247679
85	CSNK1G2	0.34729522
86	FGFR2	0.33375469
87	PLK1	0.32819948
88	PIK3CA	0.32690123
89	STK16	0.32208017
90	EIF2AK2	0.32155236
91	IGF1R	0.30252093
92	IKBKB	0.30096466
93	RAF1	0.29746977
94	PBK	0.29535904
95	PRKAA1	0.29037723
96	PRKACA	0.27468103
97	MAP2K7	0.26581902
98	MAPKAPK5	0.26066299
99	IRAK1	0.25884501
100	ROCK1	0.25577292

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.16840187
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.74765578
3	Phototransduction_Homo sapiens_hsa04744	2.59392143
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.55934841
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32461340
6	Propanoate metabolism_Homo sapiens_hsa00640	2.22608547
7	Butanoate metabolism_Homo sapiens_hsa00650	2.22464937
8	Histidine metabolism_Homo sapiens_hsa00340	2.17354358
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.10790653
10	Protein export_Homo sapiens_hsa03060	2.10121765
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.05590953
12	beta-Alanine metabolism_Homo sapiens_hsa00410	2.05004556
13	Taste transduction_Homo sapiens_hsa04742	1.96239320
14	Homologous recombination_Homo sapiens_hsa03440	1.90389472
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.89800252
16	Basal transcription factors_Homo sapiens_hsa03022	1.86847628
17	Circadian rhythm_Homo sapiens_hsa04710	1.82275115
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.82004845
19	Tyrosine metabolism_Homo sapiens_hsa00350	1.78010776
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.76963599
21	Fatty acid elongation_Homo sapiens_hsa00062	1.74459983
22	Phenylalanine metabolism_Homo sapiens_hsa00360	1.72181994
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71957674
24	Caffeine metabolism_Homo sapiens_hsa00232	1.66158084
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64913279
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62434006
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57087878
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.53664242
29	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.48004745
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.47283839
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.44907107
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.44513027
33	Peroxisome_Homo sapiens_hsa04146	1.44451458
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39294842
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38994263
36	Sphingolipid metabolism_Homo sapiens_hsa00600	1.29989912
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.25078913
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.17336064
39	Sulfur metabolism_Homo sapiens_hsa00920	1.14681615
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12177893
41	RNA degradation_Homo sapiens_hsa03018	1.12149616
42	Nicotine addiction_Homo sapiens_hsa05033	1.11832948
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.11396132
44	ABC transporters_Homo sapiens_hsa02010	1.11062118
45	One carbon pool by folate_Homo sapiens_hsa00670	1.09266974
46	Olfactory transduction_Homo sapiens_hsa04740	1.05704294
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.03957320
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00815640
49	Glutathione metabolism_Homo sapiens_hsa00480	0.97141619
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.95297453
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.94036560
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.92463687
53	Salivary secretion_Homo sapiens_hsa04970	0.91249245
54	Proteasome_Homo sapiens_hsa03050	0.90372766
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.88329746
56	Retinol metabolism_Homo sapiens_hsa00830	0.88204955
57	RNA polymerase_Homo sapiens_hsa03020	0.86881269
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.86718064
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.86291997
60	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.78915555
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77237540
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76048129
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73667912
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.72257675
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71400213
66	RNA transport_Homo sapiens_hsa03013	0.68653115
67	Metabolic pathways_Homo sapiens_hsa01100	0.67090023
68	Base excision repair_Homo sapiens_hsa03410	0.66207508
69	Insulin secretion_Homo sapiens_hsa04911	0.62793987
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62266192
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61707388
72	Regulation of autophagy_Homo sapiens_hsa04140	0.61108000
73	Fatty acid degradation_Homo sapiens_hsa00071	0.59433851
74	Oxidative phosphorylation_Homo sapiens_hsa00190	0.57160464
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56545518
76	Mineral absorption_Homo sapiens_hsa04978	0.55989450
77	Purine metabolism_Homo sapiens_hsa00230	0.55742930
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54543472
79	Mismatch repair_Homo sapiens_hsa03430	0.53724463
80	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.53527935
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53309655
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50333961
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49933023
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.47053676
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46084215
86	Renin secretion_Homo sapiens_hsa04924	0.42570583
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.42435803
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42406920
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41097821
90	Oocyte meiosis_Homo sapiens_hsa04114	0.40404389
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38283118
92	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36515478
93	Lysine degradation_Homo sapiens_hsa00310	0.36236824
94	Serotonergic synapse_Homo sapiens_hsa04726	0.34907681
95	Circadian entrainment_Homo sapiens_hsa04713	0.34016136
96	Tight junction_Homo sapiens_hsa04530	0.33719628
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30504192
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30000877
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.29543149
100	Morphine addiction_Homo sapiens_hsa05032	0.28763547

ZNF812P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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